Eric M. Shepard, Ph.D. - Publications

Affiliations: 
2006 Montana State University, Bozeman, MT 
Area:
Biochemistry

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Adelson CN, Johnston EM, Hilmer KM, Watts H, Dey SG, Brown DE, Broderick JB, Shepard EM, Dooley DM, Solomon EI. Characterization of the preprocessed copper site equilibrium in amine oxidase and assignment of the reactive copper site in topaquinone biogenesis. Journal of the American Chemical Society. PMID 31060358 DOI: 10.1021/jacs.9b01922  1
2016 Shepard EM, Byer AS, Betz JN, Peters JW, Broderick JB. A Redox Active [2Fe-2S] Cluster on the Hydrogenase Maturase HydF. Biochemistry. PMID 27232385 DOI: 10.1021/acs.biochem.6b00528  1
2015 Shepard EM, Dooley DM. Inhibition and oxygen activation in copper amine oxidases. Accounts of Chemical Research. 48: 1218-26. PMID 25897668 DOI: 10.1021/ar500460z  1
2015 Betz JN, Boswell NW, Fugate CJ, Holliday GL, Akiva E, Scott AG, Babbitt PC, Peters JW, Shepard EM, Broderick JB. [FeFe]-hydrogenase maturation: insights into the role HydE plays in dithiomethylamine biosynthesis. Biochemistry. 54: 1807-18. PMID 25654171 DOI: 10.1021/bi501205e  1
2015 Byer AS, Shepard EM, Peters JW, Broderick JB. Radical S-adenosyl-L-methionine chemistry in the synthesis of hydrogenase and nitrogenase metal cofactors. The Journal of Biological Chemistry. 290: 3987-94. PMID 25477518 DOI: 10.1074/jbc.R114.578161  1
2015 Peters JW, Schut GJ, Boyd ES, Mulder DW, Shepard EM, Broderick JB, King PW, Adams MW. [FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation. Biochimica Et Biophysica Acta. 1853: 1350-1369. PMID 25461840 DOI: 10.1016/j.bbamcr.2014.11.021  1
2014 Broderick JB, Byer AS, Duschene KS, Duffus BR, Betz JN, Shepard EM, Peters JW. H-cluster assembly during maturation of the [FeFe]-hydrogenase. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 19: 747-57. PMID 24972661 DOI: 10.1007/s00775-014-1168-8  1
2014 Shepard EM, Mus F, Betz JN, Byer AS, Duffus BR, Peters JW, Broderick JB. [FeFe]-hydrogenase maturation. Biochemistry. 53: 4090-104. PMID 24878200 DOI: 10.1021/bi500210x  1
2014 Silver SC, Gardenghi DJ, Naik SG, Shepard EM, Huynh BH, Szilagyi RK, Broderick JB. Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 19: 465-83. PMID 24532333 DOI: 10.1007/s00775-014-1104-y  1
2014 Broderick JB, Duffus BR, Duschene KS, Shepard EM. Radical S-adenosylmethionine enzymes. Chemical Reviews. 114: 4229-317. PMID 24476342 DOI: 10.1021/cr4004709  1
2014 Boyd ES, Schut GJ, Shepard EM, Broderick JB, Adams MWW, Peters JW. Origin and evolution of Fe-S proteins and enzymes Iron-Sulfur Clusters in Chemistry and Biology. 619-636. DOI: 10.1515/9783110308426.619  1
2014 Shepard EM, Mus F, Betz JN, Byer AS, Duffus BR, Peters JW, Broderick JB. [FeFe]-hydrogenase maturation (Biochemistry (2014) 53:25 (4090-4104) DOI:10.1021/bi500210x) Biochemistry. 53: 5588. DOI: 10.1021/bi500981n  1
2013 Driesener RC, Duffus BR, Shepard EM, Bruzas IR, Duschene KS, Coleman NJ, Marrison AP, Salvadori E, Kay CW, Peters JW, Broderick JB, Roach PL. Biochemical and kinetic characterization of radical S-adenosyl-L-methionine enzyme HydG. Biochemistry. 52: 8696-707. PMID 24206022 DOI: 10.1021/bi401143s  1
2013 Mulder DW, Ratzloff MW, Shepard EM, Byer AS, Noone SM, Peters JW, Broderick JB, King PW. EPR and FTIR analysis of the mechanism of H2 activation by [FeFe]-hydrogenase HydA1 from Chlamydomonas reinhardtii. Journal of the American Chemical Society. 135: 6921-9. PMID 23578101 DOI: 10.1021/ja4000257  1
2012 Joshi N, Shepard EM, Byer AS, Swanson KD, Broderick JB, Peters JW. Iron-sulfur cluster coordination in the [FeFe]-hydrogenase H cluster biosynthetic factor HydF. Febs Letters. 586: 3939-43. PMID 23041346 DOI: 10.1016/j.febslet.2012.09.028  1
2012 Duffus BR, Hamilton TL, Shepard EM, Boyd ES, Peters JW, Broderick JB. Radical AdoMet enzymes in complex metal cluster biosynthesis. Biochimica Et Biophysica Acta. 1824: 1254-63. PMID 22269887 DOI: 10.1016/j.bbapap.2012.01.002  1
2011 Mulder DW, Shepard EM, Meuser JE, Joshi N, King PW, Posewitz MC, Broderick JB, Peters JW. Insights into [FeFe]-hydrogenase structure, mechanism, and maturation. Structure (London, England : 1993). 19: 1038-52. PMID 21827941 DOI: 10.1016/j.str.2011.06.008  1
2011 Shepard EM, Boyd ES, Broderick JB, Peters JW. Biosynthesis of complex iron-sulfur enzymes. Current Opinion in Chemical Biology. 15: 319-27. PMID 21393052 DOI: 10.1016/j.cbpa.2011.02.012  1
2011 Rokhsana D, Shepard EM, Brown DE, Dooley DM. Amine Oxidase and Galactose Oxidase Copper-Oxygen Chemistry. 53-106. DOI: 10.1002/9781118094365.ch3  1
2010 Shepard EM, Duffus BR, George SJ, McGlynn SE, Challand MR, Swanson KD, Roach PL, Cramer SP, Peters JW, Broderick JB. [FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide. Journal of the American Chemical Society. 132: 9247-9. PMID 20565074 DOI: 10.1021/ja1012273  1
2010 Shepard EM, McGlynn SE, Bueling AL, Grady-Smith CS, George SJ, Winslow MA, Cramer SP, Peters JW, Broderick JB. Synthesis of the 2Fe subcluster of the [FeFe]-hydrogenase H cluster on the HydF scaffold. Proceedings of the National Academy of Sciences of the United States of America. 107: 10448-53. PMID 20498089 DOI: 10.1073/pnas.1001937107  1
2010 Driesener RC, Challand MR, McGlynn SE, Shepard EM, Boyd ES, Broderick JB, Peters JW, Roach PL. [FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine. Angewandte Chemie (International Ed. in English). 49: 1687-90. PMID 20108298 DOI: 10.1002/anie.200907047  1
2010 McGlynn SE, Boyd ES, Shepard EM, Lange RK, Gerlach R, Broderick JB, Peters JW. Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor. Journal of Bacteriology. 192: 595-8. PMID 19897660 DOI: 10.1128/JB.01125-09  1
2010 Shepard EM, Broderick JB. S-adenosylmethionine and iron-sulfur clusters in biological radical reactions: The radical SAM superfamily Comprehensive Natural Products Ii: Chemistry and Biology. 8: 625-661.  1
2009 McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM. Structure and inhibition of human diamine oxidase. Biochemistry. 48: 9810-22. PMID 19764817 DOI: 10.1021/bi9014192  1
2009 McGlynn SE, Mulder DW, Shepard EM, Broderick JB, Peters JW. Hydrogenase cluster biosynthesis: organometallic chemistry nature's way. Dalton Transactions (Cambridge, England : 2003). 4274-85. PMID 19662302 DOI: 10.1039/b821432h  1
2009 Chandra T, Silver SC, Zilinskas E, Shepard EM, Broderick WE, Broderick JB. Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct. Journal of the American Chemical Society. 131: 2420-1. PMID 19178276 DOI: 10.1021/ja807375c  1
2008 Shepard EM, Okonski KM, Dooley DM. Kinetics and spectroscopic evidence that the Cu(I)-semiquinone intermediate reduces molecular oxygen in the oxidative half-reaction of Arthrobacter globiformis amine oxidase. Biochemistry. 47: 13907-20. PMID 19053231 DOI: 10.1021/bi8011516  1
2008 Mukherjee A, Smirnov VV, Lanci MP, Brown DE, Shepard EM, Dooley DM, Roth JP. Inner-sphere mechanism for molecular oxygen reduction catalyzed by copper amine oxidases. Journal of the American Chemical Society. 130: 9459-73. PMID 18582059 DOI: 10.1021/ja801378f  1
2008 McGlynn SE, Shepard EM, Winslow MA, Naumov AV, Duschene KS, Posewitz MC, Broderick WE, Broderick JB, Peters JW. HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis. Febs Letters. 582: 2183-7. PMID 18501709 DOI: 10.1016/j.febslet.2008.04.063  1
2006 Duff AP, Shepard EM, Langley DB, Dooley DM, Freeman HC, Guss JM. A C-terminal disulfide bond in the copper-containing amine oxidase from pea seedlings violates the twofold symmetry of the molecular dimer. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 1168-73. PMID 17142890 DOI: 10.1107/S1744309106043685  1
2006 Shepard EM, Dooley DM. Intramolecular electron transfer rate between active-site copper and TPQ in Arthrobacter globiformis amine oxidase. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 11: 1039-48. PMID 16924556 DOI: 10.1007/s00775-006-0153-2  1
2006 Juda GA, Shepard EM, Elmore BO, Dooley DM. A comparative study of the binding and inhibition of four copper-containing amine oxidases by azide: implications for the role of copper during the oxidative half-reaction. Biochemistry. 45: 8788-800. PMID 16846222 DOI: 10.1021/bi060481k  1
2006 Qiao C, Ling KQ, Shepard EM, Dooley DM, Sayre LM. Mechanism-based cofactor derivatization of a copper amine oxidase by a branched primary amine recruits the oxidase activity of the enzyme to turn inactivator into substrate. Journal of the American Chemical Society. 128: 6206-19. PMID 16669691 DOI: 10.1021/ja058838f  1
2004 Duff AP, Trambaiolo DM, Cohen AE, Ellis PJ, Juda GA, Shepard EM, Langley DB, Dooley DM, Freeman HC, Guss JM. Using xenon as a probe for dioxygen-binding sites in copper amine oxidases. Journal of Molecular Biology. 344: 599-607. PMID 15533431 DOI: 10.1016/j.jmb.2004.09.075  1
2004 O'Connell KM, Langley DB, Shepard EM, Duff AP, Jeon HB, Sun G, Freeman HC, Guss JM, Sayre LM, Dooley DM. Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation. Biochemistry. 43: 10965-78. PMID 15323556 DOI: 10.1021/bi0492004  1
2004 Shepard EM, Juda GA, Ling KQ, Sayre LM, Dooley DM. Cyanide as a copper and quinone-directed inhibitor of amine oxidases from pea seedlings ( Pisum sativum) and Arthrobacter globiformis: evidence for both copper coordination and cyanohydrin derivatization of the quinone cofactor. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 9: 256-68. PMID 14986071 DOI: 10.1007/s00775-004-0522-7  1
2003 Duff AP, Cohen AE, Ellis PJ, Kuchar JA, Langley DB, Shepard EM, Dooley DM, Freeman HC, Guss JM. The crystal structure of Pichia pastoris lysyl oxidase. Biochemistry. 42: 15148-57. PMID 14690425 DOI: 10.1021/bi035338v  1
2003 Shepard EM, Heggem H, Juda GA, Dooley DM. Inhibition of six copper-containing amine oxidases by the antidepressant drug tranylcypromine. Biochimica Et Biophysica Acta. 1647: 252-9. PMID 12686142 DOI: 10.1016/S1570-9639(03)00062-1  1
2002 Lee Y, Ling KQ, Lu X, Silverman RB, Shepard EM, Dooley DM, Sayre LM. 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases. Journal of the American Chemical Society. 124: 12135-43. PMID 12371853 DOI: 10.1021/ja0205434  1
2002 Shepard EM, Smith J, Elmore BO, Kuchar JA, Sayre LM, Dooley DM. Towards the development of selective amine oxidase inhibitors. Mechanism-based inhibition of six copper containing amine oxidases. European Journal of Biochemistry / Febs. 269: 3645-58. PMID 12153561 DOI: 10.1046/j.1432-1033.2002.03035.x  1
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