Huay-Keng Loke, Ph.D. - Publications

2001 Texas A & M University, College Station, TX, United States 
Biochemistry, Inorganic Chemistry

13 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Yang X, Brownell JE, Xu Q, Zhu F, Ma J, Loke HK, Rollins N, Soucy TA, Minissale JJ, Thomas MP, Mallender WD, Dick LR, Li P, Liao H. Absolute quantification of E1, ubiquitin-like proteins and Nedd8-MLN4924 adduct by mass spectrometry. Cell Biochemistry and Biophysics. 67: 139-47. PMID 23754621 DOI: 10.1007/s12013-013-9625-5  1
2013 Yan ZH, Burkhardt A, Loke HK, Chen J, Xu Q, Brauer P, Ma J, Lin Y, Garcia K, Dick LR, Bembenek ME. Quantifiable analysis of cellular pathway inhibition of a Nedd8-activating enzyme inhibitor, MLN4924, using AlphaScreen. Analytical Biochemistry. 439: 109-15. PMID 23624319 DOI: 10.1016/j.ab.2013.04.016  1
2012 Milhollen MA, Thomas MP, Narayanan U, Traore T, Riceberg J, Amidon BS, Bence NF, Bolen JB, Brownell J, Dick LR, Loke HK, McDonald AA, Ma J, Manfredi MG, Sells TB, et al. Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924. Cancer Cell. 21: 388-401. PMID 22439935 DOI: 10.1016/j.ccr.2012.02.009  1
2012 Gavin JM, Chen JJ, Liao H, Rollins N, Yang X, Xu Q, Ma J, Loke HK, Lingaraj T, Brownell JE, Mallender WD, Gould AE, Amidon BS, Dick LR. Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6. The Journal of Biological Chemistry. 287: 15512-22. PMID 22427669 DOI: 10.1074/jbc.M111.336198  1
2011 Chen JJ, Tsu CA, Gavin JM, Milhollen MA, Bruzzese FJ, Mallender WD, Sintchak MD, Bump NJ, Yang X, Ma J, Loke HK, Xu Q, Li P, Bence NF, Brownell JE, et al. Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues. The Journal of Biological Chemistry. 286: 40867-77. PMID 21969368 DOI: 10.1074/jbc.M111.279984  1
2011 Yan ZH, Madison LL, Burkhardt A, Yu J, Tayber O, Li Z, Wu D, Loke HK, Wysong DR, Iartchouk N, Smith MD, Kuranda M, Li P, Bembenek ME. Analysis of two pharmacodynamic biomarkers using acoustic micro magnetic particles on the ViBE bioanalyzer. Analytical Biochemistry. 410: 13-8. PMID 21078283 DOI: 10.1016/j.ab.2010.11.012  1
2011 Bembenek ME, Burkhardt A, Ma J, Li Z, Loke HK, Wu D, Xu Q, Tayber O, Xie L, Li P, Li L. Determination of complementary antibody pairs using protein A capture with the AlphaScreen assay format. Analytical Biochemistry. 408: 321-7. PMID 20868646 DOI: 10.1016/j.ab.2010.09.021  1
2010 Brownell JE, Sintchak MD, Gavin JM, Liao H, Bruzzese FJ, Bump NJ, Soucy TA, Milhollen MA, Yang X, Burkhardt AL, Ma J, Loke HK, Lingaraj T, Wu D, Hamman KB, et al. Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Molecular Cell. 37: 102-11. PMID 20129059 DOI: 10.1016/j.molcel.2009.12.024  1
2009 Bruzzese FJ, Tsu CA, Ma J, Loke HK, Wu D, Li Z, Tayber O, Dick LR. Development of a charcoal paper adenosine triphosphate:pyrophosphate exchange assay: kinetic characterization of NEDD8 activating enzyme. Analytical Biochemistry. 394: 24-9. PMID 19602421 DOI: 10.1016/j.ab.2009.07.011  1
2005 Tan X, Loke HK, Fitch S, Lindahl PA. The tunnel of acetyl-coenzyme a synthase/carbon monoxide dehydrogenase regulates delivery of CO to the active site. Journal of the American Chemical Society. 127: 5833-9. PMID 15839681 DOI: 10.1021/ja043701v  1
2003 Loke HK, Lindahl PA. Identification and preliminary characterization of AcsF, a putative Ni-insertase used in the biosynthesis of acetyl-CoA synthase from Clostridium thermoaceticum. Journal of Inorganic Biochemistry. 93: 33-40. PMID 12538050 DOI: 10.1016/S0162-0134(02)00457-9  1
2002 Loke HK, Tan X, Lindahl PA. Genetic construction of truncated and chimeric metalloproteins derived from the alpha subunit of acetyl-CoA synthase from Clostridium thermoaceticum. Journal of the American Chemical Society. 124: 8667-72. PMID 12121109 DOI: 10.1021/ja025924w  1
2000 Loke HK, Bennett GN, Lindahl PA. Active acetyl-CoA synthase from Clostridium thermoaceticum obtained by cloning and heterologous expression of acsAB in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 97: 12530-5. PMID 11050160 DOI: 10.1073/pnas.220404397  1
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