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Roman Manetsch - Publications

Affiliations: 
2002-2005 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 2014- Chemistry and Chemical Biology Northeastern University, Boston, MA, United States 
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Donnelly DP, Dowgiallo MG, Salisbury JP, Aluri KC, Iyengar S, Chaudhari M, Mathew M, Miele I, Auclair JR, Lopez SA, Manetsch R, Agar JN. Cyclic Thiosulfinates and Cyclic Disulfides Selectively Crosslink Thiols While Avoiding Modification of Lone Thiols. Journal of the American Chemical Society. PMID 29851341 DOI: 10.1021/Jacs.8B01136  0.331
2018 Kumar AB, Manetsch R. Ammonia-free synthesis of 3-trifluoromethyl-3-phenyldiaziridine Synthetic Communications. 48: 626-631. DOI: 10.1080/00397911.2017.1354026  0.315
2017 Neelarapu R, Maignan JR, Lichorowic CL, Monastyrskyi A, Mutka TS, LaCrue AN, Blake LD, Casandra D, Mashkouri S, Burrows JN, Willis PA, Kyle DE, Manetsch R. Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies. Journal of Medicinal Chemistry. PMID 29215279 DOI: 10.1021/Acs.Jmedchem.7B00738  0.396
2017 Blake LD, Johnson ME, Siegel SV, McQueen A, Iyamu ID, Shaikh AK, Shultis MW, Manetsch R, Kyle DE. Menoctone resistance in malaria parasites is conferred by M133I mutations in cytochrome b that are transmissible through mosquitos. Antimicrobial Agents and Chemotherapy. PMID 28584157 DOI: 10.1128/Aac.00689-17  0.304
2017 Brockmeyer F, Manetsch R. Progress in the Optimization of 4(1H)-Quinolone Derivatives as Antimalarials Targeting the Erythrocytic, the Exoerythrocytic and the Transmitting Stages of the Malaria Parasite. Chimia. 71: 213-219. PMID 28446339 DOI: 10.2533/Chimia.2017.213  0.375
2017 Fleeman R, Van Horn KS, Barber MM, Burda WN, Flanigan DL, Manetsch R, Shaw LN. Characterizing the Antimicrobial Activity of N(2), N(4) -Disubstituted Quinazoline-2,4-Diamines Towards Multidrug Resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy. PMID 28289036 DOI: 10.1128/Aac.00059-17  0.346
2017 Namelikonda NK, Monastyrskyi A, Manetsch R. Scalable Multigram Syntheses of Antimalarial 4(1H )-Quinolones ELQ-300 and P4Q-391 European Journal of Organic Chemistry. 2017: 3328-3334. DOI: 10.1002/Ejoc.201700326  0.395
2016 Maignan JR, Lichorowic CL, Giarrusso J, Blake L, Casandra D, Mutka TS, LaCrue AN, Burrows JN, Willis PA, Kyle DE, Manetsch R. ICI 56,780 Optimization: Structural-Activity and Relationship Studies of 7-(2-phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity. Journal of Medicinal Chemistry. PMID 27291102 DOI: 10.1021/Acs.Jmedchem.6B00759  0.378
2016 Roberts BF, Iyamu ID, Lee S, Lee E, Ayong L, Kyle DE, Yuan Y, Manetsch R, Chakrabarti D. Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages. International Journal For Parasitology. Drugs and Drug Resistance. 6: 85-92. PMID 27054067 DOI: 10.1016/J.Ijpddr.2016.02.004  0.376
2015 Zhu X, Van Horn KS, Barber MM, Yang S, Wang MZ, Manetsch R, Werbovetz KA. SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines. Bioorganic & Medicinal Chemistry. PMID 25749014 DOI: 10.1016/J.Bmc.2015.02.020  0.308
2015 Mahajan S, Manetsch R, Merkler DJ, Stevens SM. Synthesis and evaluation of a novel adenosine-ribose probe for global-scale profiling of nucleoside and nucleotide-binding proteins. Plos One. 10: e0115644. PMID 25671571 DOI: 10.1371/Journal.Pone.0115644  0.306
2015 Monastyrskyi A, Namelikonda NK, Manetsch R. Metal-free arylation of ethyl acetoacetate with hypervalent diaryliodonium salts: an immediate access to diverse 3-aryl-4(1H)-quinolones. The Journal of Organic Chemistry. 80: 2513-20. PMID 25558982 DOI: 10.1021/Jo5023958  0.325
2014 Cross RM, Flanigan DL, Monastyrskyi A, LaCrue AN, Sáenz FE, Maignan JR, Mutka TS, White KL, Shackleford DM, Bathurst I, Fronczek FR, Wojtas L, Guida WC, Charman SA, Burrows JN, ... ... Manetsch R, et al. Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium. Journal of Medicinal Chemistry. 57: 8860-79. PMID 25148516 DOI: 10.1021/Jm500942V  0.368
2014 Monastyrskyi A, Kyle DE, Manetsch R. 4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities. Current Topics in Medicinal Chemistry. 14: 1693-705. PMID 25116582 DOI: 10.2174/1568026614666140808124638  0.32
2014 Van Horn KS, Zhu X, Pandharkar T, Yang S, Vesely B, Vanaerschot M, Dujardin JC, Rijal S, Kyle DE, Wang MZ, Werbovetz KA, Manetsch R. Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines. Journal of Medicinal Chemistry. 57: 5141-56. PMID 24874647 DOI: 10.1021/Jm5000408  0.359
2014 Van Horn KS, Burda WN, Fleeman R, Shaw LN, Manetsch R. Antibacterial activity of a series of N2,N4-disubstituted quinazoline-2,4-diamines. Journal of Medicinal Chemistry. 57: 3075-93. PMID 24625106 DOI: 10.1021/Jm500039E  0.343
2014 Campbell CO, Santiago DN, Guida WC, Manetsch R, Adams JH. In silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discovery. Chemical Biology & Drug Design. 84: 158-68. PMID 24605883 DOI: 10.1111/Cbdd.12315  0.395
2014 Babu Kumar A, Manetsch R. Regioselective O2′,O3′-deacetylations of peracetylated ribonucleosides by using tetra-n-butylammonium fluoride European Journal of Organic Chemistry. 2014: 3551-3555. DOI: 10.1002/Ejoc.201400085  0.364
2013 Sáenz FE, Lacrue AN, Cross RM, Maignan JR, Udenze KO, Manetsch R, Kyle DE. 4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni. Antimicrobial Agents and Chemotherapy. 57: 6187-95. PMID 24080648 DOI: 10.1128/Aac.00492-13  0.304
2013 Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, ... ... Manetsch R, et al. Quinolone-3-diarylethers: a new class of antimalarial drug. Science Translational Medicine. 5: 177ra37. PMID 23515079 DOI: 10.1126/Scitranslmed.3005029  0.337
2013 Kulkarni SS, Hu X, Manetsch R. A simple base-mediated amidation of aldehydes with azides. Chemical Communications (Cambridge, England). 49: 1193-5. PMID 23287824 DOI: 10.1039/C2Cc37289D  0.334
2013 Lacrue AN, Sáenz FE, Cross RM, Udenze KO, Monastyrskyi A, Stein S, Mutka TS, Manetsch R, Kyle DE. 4(1H)-Quinolones with liver stage activity against Plasmodium berghei. Antimicrobial Agents and Chemotherapy. 57: 417-24. PMID 23129047 DOI: 10.1128/Aac.00793-12  0.326
2012 Kumar AB, Anderson JM, Melendez AL, Manetsch R. Synthesis and structure-activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 4740-4. PMID 22727644 DOI: 10.1016/J.Bmcl.2012.05.072  0.413
2012 Namelikonda NK, Manetsch R. Sulfo-click reaction via in situ generated thioacids and its application in kinetic target-guided synthesis. Chemical Communications (Cambridge, England). 48: 1526-8. PMID 21892513 DOI: 10.1039/C1Cc14724B  0.334
2011 Cross RM, Namelikonda NK, Mutka TS, Luong L, Kyle DE, Manetsch R. Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones. Journal of Medicinal Chemistry. 54: 8321-7. PMID 22111907 DOI: 10.1021/Jm200718M  0.344
2011 Kumar AB, Anderson JM, Manetsch R. Design, synthesis and photoactivation studies of fluorous photolabels. Organic & Biomolecular Chemistry. 9: 6284-92. PMID 21785789 DOI: 10.1039/C1Ob05748K  0.341
2011 Cross RM, Maignan JR, Mutka TS, Luong L, Sargent J, Kyle DE, Manetsch R. Optimization of 1,2,3,4-tetrahydroacridin-9(10H)-ones as antimalarials utilizing structure-activity and structure-property relationships. Journal of Medicinal Chemistry. 54: 4399-426. PMID 21630666 DOI: 10.1021/Jm200015A  0.391
2011 Kulkarni SS, Hu X, Doi K, Wang HG, Manetsch R. Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis. Acs Chemical Biology. 6: 724-32. PMID 21506574 DOI: 10.1021/Cb200085Q  0.363
2010 Cross RM, Monastyrskyi A, Mutka TS, Burrows JN, Kyle DE, Manetsch R. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity. Journal of Medicinal Chemistry. 53: 7076-94. PMID 20828199 DOI: 10.1021/Jm1007903  0.366
2010 Hu X, Manetsch R. Kinetic target-guided synthesis. Chemical Society Reviews. 39: 1316-24. PMID 20309488 DOI: 10.1039/B904092G  0.433
2008 Hu X, Sun J, Wang HG, Manetsch R. Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides. Journal of the American Chemical Society. 130: 13820-1. PMID 18811158 DOI: 10.1021/Ja802683U  0.326
2008 Radi? Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. Probing gorge dimensions of cholinesterases by freeze-frame click chemistry. Chemico-Biological Interactions. 175: 161-5. PMID 18555981 DOI: 10.1016/J.Cbi.2008.04.048  0.561
2006 Sharpless KB, Manetsch R. In situ click chemistry: a powerful means for lead discovery. Expert Opinion On Drug Discovery. 1: 525-38. PMID 23506064 DOI: 10.1517/17460441.1.6.525  0.534
2005 Radi? Z, Manetsch R, Krasi?ski A, Raushel J, Yamauchi J, Garcia C, Kolb H, Sharpless KB, Taylor P. Molecular basis of interactions of cholinesterases with tight binding inhibitors. Chemico-Biological Interactions. 157: 133-41. PMID 16289416 DOI: 10.1016/J.Cbi.2005.10.020  0.631
2005 Krasi?ski A, Radi? Z, Manetsch R, Raushel J, Taylor P, Sharpless KB, Kolb HC. In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors. Journal of the American Chemical Society. 127: 6686-92. PMID 15869290 DOI: 10.1021/Ja043031T  0.667
2005 Zheng L, Manetsch R, Woggon WD, Baumann U, Reymond JL. Mechanistic study of proton transfer and hysteresis in catalytic antibody 16E7 by site-directed mutagenesis and homology modeling. Bioorganic & Medicinal Chemistry. 13: 1021-9. PMID 15670909 DOI: 10.1016/J.Bmc.2004.11.041  0.634
2004 Manetsch R, Krasi?ski A, Radi? Z, Raushel J, Taylor P, Sharpless KB, Kolb HC. In situ click chemistry: enzyme inhibitors made to their own specifications. Journal of the American Chemical Society. 126: 12809-18. PMID 15469276 DOI: 10.1021/Ja046382G  0.651
2004 Manetsch R, Zheng L, Reymond MT, Woggon WD, Reymond JL. A catalytic antibody against a tocopherol cyclase inhibitor. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 2487-506. PMID 15146522 DOI: 10.1002/Chem.200305629  0.649
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