Rudi Fasan, PhD - Publications

2008- Chemistry University of Rochester, Rochester, NY 
Bioorganic Chemistry, Chemical Biology, Biocatalysis, Protein Engineering

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Nam D, Steck V, Potenzino RJ, Fasan R. A Diverse Library of Chiral Cyclopropane Scaffolds via Chemoenzymatic Assembly and Diversification of Cyclopropyl Ketones. Journal of the American Chemical Society. PMID 33497207 DOI: 10.1021/jacs.0c09504  1
2020 Fasan R, Carminati DM, Decaens J, Couve-Bonnaire S, Jubault P. Biocatalytic strategy for the highly stereoselective synthesis of CHF2-containing trisubstituted cyclopropanes. Angewandte Chemie (International Ed. in English). PMID 33337576 DOI: 10.1002/anie.202015895  0.64
2020 Iannuzzelli JA, Fasan R. Expanded toolbox for directing the biosynthesis of macrocyclic peptides in bacterial cells. Chemical Science. 11: 6202-6208. PMID 32953014 DOI: 10.1039/D0Sc01699C  0.84
2020 Carminati DM, Moore EJ, Fasan R. Strategies for the expression and characterization of artificial myoglobin-based carbene transferases. Methods in Enzymology. 644: 35-61. PMID 32943150 DOI: 10.1016/Bs.Mie.2020.07.007  0.96
2020 Fasan R, Ren X, Liu N, Chandgude AL. An enzymatic platform for the highy enantioselective and stereodivergent construction of cyclopropyl-δ-lactones. Angewandte Chemie (International Ed. in English). PMID 32667122 DOI: 10.1002/Anie.202007953  0.72
2020 Pineda-Knauseder AJ, Vargas DA, Fasan R. Organic solvent stability and long-term storage of myoglobin-based carbene transfer biocatalysts. Biotechnology and Applied Biochemistry. PMID 32542734 DOI: 10.1002/Bab.1972  0.48
2020 Steck V, Kolev JN, Ren X, Fasan R. Mechanism-Guided Design and Discovery of Efficient P450-Derived C-H Amination Biocatalysts. Journal of the American Chemical Society. PMID 32407077 DOI: 10.1021/Jacs.9B12859  1
2020 Ren X, Chandgude AL, Fasan R. Highly Stereoselective Synthesis of Fused Cyclopropane-γ-Lactams via Biocatalytic Iron-Catalyzed Intramolecular Cyclopropanation. Acs Catalysis. 10: 2308-2313. PMID 32257580 DOI: 10.1021/Acscatal.9B05383  0.72
2020 Steck V, Sreenilayam G, Fasan R. Selective Functionalization of Aliphatic Amines via Myoglobin-catalyzed Carbene N-H Insertion. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 31: 224-229. PMID 32255925 DOI: 10.1055/S-0039-1690007  1
2020 Owens AE, Iannuzzelli JA, Gu Y, Fasan R. MOrPH-PhD: An Integrated Phage Display Platform for the Discovery of Functional Genetically Encoded Peptide Macrocycles. Acs Central Science. 6: 368-381. PMID 32232137 DOI: 10.1021/Acscentsci.9B00927  1
2020 Vila MA, Steck V, Giordano SR, Carrera I, Fasan R. C-H Amination via Nitrene Transfer Catalyzed by Mononuclear Non-Heme Iron-Dependent Enzymes. Chembiochem : a European Journal of Chemical Biology. PMID 32189465 DOI: 10.1002/Cbic.201900783  1
2020 Steck V, Carminati DM, Johnson N, Fasan R. Enantioselective Synthesis of Chiral Amines via Biocatalytic Carbene N—H Insertion Acs Catalysis. 10967-10977. DOI: 10.1021/Acscatal.0C02794  1
2019 Fasan R, Jennifer Kan SB, Zhao H. A Continuing Career in Biocatalysis: Frances H. Arnold. Acs Catalysis. 9: 9775-9788. PMID 32728486 DOI: 10.1021/Acscatal.9B02737  0.84
2019 Carminati DM, Fasan R. Stereoselective Cyclopropanation of Electron-Deficient Olefins with a Cofactor Redesigned Carbene Transferase Featuring Radical Reactivity. Acs Catalysis. 9: 9683-9697. PMID 32257582 DOI: 10.1021/Acscatal.9B02272  0.64
2019 Bonn-Breach R, Gu Y, Jenkins J, Fasan R, Wedekind J. Structure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design. Acta Crystallographica. Section D, Structural Biology. 75: 969-979. PMID 31692471 DOI: 10.1107/S2059798319012890  0.84
2019 Khade RL, Chandgude AL, Fasan R, Zhang Y. Mechanistic Investigation of Biocatalytic Heme Carbenoid Si-H Insertions. Chemcatchem. 11: 3101-3108. PMID 31428208 DOI: 10.1002/Cctc.201801755  0.64
2019 Tinoco A, Wei Y, Bacik JP, Carminati DM, Moore EJ, Ando N, Zhang Y, Fasan R. Origin of high stereocontrol in olefin cyclopropanation catalyzed by an engineered carbene transferase. Acs Catalysis. 9: 1514-1524. PMID 31134138 DOI: 10.1021/Acscatal.8B04073  0.96
2019 Moore EJ, Fasan R. Effect of proximal ligand substitutions on the carbene and nitrene transferase activity of myoglobin. Tetrahedron, Asymmetry. 75: 2357-2363. PMID 31133770 DOI: 10.1016/J.Tet.2019.03.009  0.96
2019 Fasan R, Vargas D, Khade R, Zhang Y. Biocatalytic strategy for highly diastereo- and enantioselective synthesis of 2,3-dihydrobenzofuran based tricyclic scaffolds. Angewandte Chemie (International Ed. in English). PMID 31099936 DOI: 10.1002/Anie.201903455  0.64
2019 Chandgude ALL, Ren X, Fasan R. Stereodivergent Intramolecular Cyclopropanation Enabled by Engineered Carbene Transferases. Journal of the American Chemical Society. PMID 31099569 DOI: 10.1021/Jacs.9B02700  0.72
2018 Fasan R, Vargas DA, Tinoco A, Tyagi V. Myoglobin-catalyzed C-H functionalization of unprotected indoles. Angewandte Chemie (International Ed. in English). PMID 29905974 DOI: 10.1002/Anie.201804779  1
2018 Moore EJ, Steck V, Bajaj P, Fasan R. Chemoselective Cyclopropanation over Carbene Y-H insertion Catalyzed by an Engineered Carbene Transferase. The Journal of Organic Chemistry. PMID 29905476 DOI: 10.1021/Acs.Joc.8B00946  1
2017 Sreenilayam G, Moore EJ, Steck V, Fasan R. Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts. Advanced Synthesis & Catalysis. 359: 2076-2089. PMID 29606929 DOI: 10.1002/Adsc.201700202  1
2017 Sreenilayam G, Moore EJ, Steck V, Fasan R. Stereoselective olefin cyclopropanation under aerobic conditions with an artificial enzyme incorporating an iron-chlorin e6 cofactor. Acs Catalysis. 7: 7629-7633. PMID 29576911 DOI: 10.1021/Acscatal.7B02583  1
2017 Saab-Rincon G, Alwaseem H, Guzmán-Luna V, Olvera L, Fasan R. Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis. Chembiochem : a European Journal of Chemical Biology. PMID 29276819 DOI: 10.1002/Cbic.201700546  1
2017 Wei Y, Tinoco A, Steck V, Fasan R, Zhang Y. Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution. Journal of the American Chemical Society. PMID 29268614 DOI: 10.1021/Jacs.7B09171  1
2017 Moore EJ, Zorine D, Hansen WA, Khare SD, Fasan R. Enzyme stabilization via computationally guided protein stapling. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109284 DOI: 10.1073/Pnas.1708907114  0.96
2017 Alwaseem H, Frisch BJ, Fasan R. Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis. Bioorganic & Medicinal Chemistry. PMID 28826596 DOI: 10.1016/J.Bmc.2017.08.009  1
2017 Owens AE, de Paola I, Hansen WA, Liu YW, Khare SD, Fasan R. Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction. Journal of the American Chemical Society. PMID 28759213 DOI: 10.1021/Jacs.7B06087  1
2017 Brandenberg OF, Fasan R, Arnold FH. Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions. Current Opinion in Biotechnology. 47: 102-111. PMID 28711855 DOI: 10.1016/J.Copbio.2017.06.005  1
2017 Owens AE, Grasso KT, Ziegler CA, Fasan R. Two-tier Screening Platform for Directed Evolution of Aminoacyl-tRNA Synthetases with Enhanced Stop Codon Suppression Efficiency. Chembiochem : a European Journal of Chemical Biology. PMID 28383180 DOI: 10.1002/Cbic.201700039  1
2017 Tinoco A, Steck V, Tyagi V, Fasan R. Highly diastereo- and enantioselective synthesis of trifluoromethyl-substituted cyclopropanes via myoglobin-catalyzed transfer of trifluoromethylcarbene. Journal of the American Chemical Society. PMID 28366001 DOI: 10.1021/Jacs.7B00768  1
2017 Bionda N, Fasan R. Ribosomal Synthesis of Thioether-Bridged Bicyclic Peptides. Methods in Molecular Biology (Clifton, N.J.). 1495: 57-76. PMID 27714610 DOI: 10.1007/978-1-4939-6451-2_5  1
2016 Bajaj P, Sreenilayam G, Tyagi V, Fasan R. Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity. Angewandte Chemie (International Ed. in English). PMID 27885768 DOI: 10.1002/Anie.201608680  1
2016 Giovani S, Alwaseem H, Fasan R. Aldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides. Chemcatchem. 8: 2609-2613. PMID 27867424 DOI: 10.1002/Cctc.201600487  1
2016 Tyagi V, Sreenilayam G, Bajaj P, Tinoco A, Fasan R. Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction. Angewandte Chemie (International Ed. in English). PMID 27647732 DOI: 10.1002/Anie.201607278  1
2016 Tyagi V, Alwaseem H, O'Dwyer KM, Ponder J, Li QY, Jordan CT, Fasan R. Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs. Bioorganic & Medicinal Chemistry. PMID 27396927 DOI: 10.1016/J.Bmc.2016.06.028  1
2016 Frost JR, Wu Z, Lam YC, Owens AE, Fasan R. Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids. Organic & Biomolecular Chemistry. PMID 27064594 DOI: 10.1039/C6Ob00192K  1
2016 Giovani S, Singh R, Fasan R. Efficient conversion of primary azides to aldehydes catalyzed by active site variants of myoglobin. Chemical Science (Royal Society of Chemistry : 2010). 7: 234-239. PMID 26900445 DOI: 10.1039/C5Sc02857D  1
2016 Tyagi V, Fasan R. Myoglobin-Catalyzed Olefination of Aldehydes. Angewandte Chemie (International Ed. in English). 55: 2512-6. PMID 26765247 DOI: 10.1002/Anie.201508817  1
2016 Giovani S, Alwaseem H, Fasan R. Aldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides Chemcatchem. 8: 2609-2613. DOI: 10.1002/cctc.201600487  1
2015 Bionda N, Fasan R. Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli. Chembiochem : a European Journal of Chemical Biology. 16: 2011-6. PMID 26179106 DOI: 10.1002/Cbic.201500179  1
2015 Tyagi V, Bonn RB, Fasan R. Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts†. Chemical Science (Royal Society of Chemistry : 2010). 6: 2488-2494. PMID 26101581 DOI: 10.1039/C5Sc00080G  1
2015 Singh R, Kolev JN, Sutera PA, Fasan R. Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones. Acs Catalysis. 5: 1685-1691. PMID 25954592 DOI: 10.1021/Cs5018612  1
2015 Frost JR, Jacob NT, Papa LJ, Owens AE, Fasan R. Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids. Acs Chemical Biology. 10: 1805-16. PMID 25933125 DOI: 10.1021/Acschembio.5B00119  1
2015 Smith JM, Fasan R. Synthesis of macrocyclic organo-peptide hybrids from ribosomal polypeptide precursors via CuAAC-/hydrazide-mediated cyclization. Methods in Molecular Biology (Clifton, N.J.). 1248: 23-38. PMID 25616323 DOI: 10.1007/978-1-4939-2020-4_2  1
2015 Sreenilayam G, Fasan R. Correction: Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates. Chemical Communications (Cambridge, England). 51: 1744. PMID 25557011 DOI: 10.1039/C4Cc90486A  1
2015 Bordeaux M, Tyagi V, Fasan R. Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts. Angewandte Chemie (International Ed. in English). 54: 1744-8. PMID 25538035 DOI: 10.1002/Anie.201409928  1
2015 Sreenilayam G, Fasan R. Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates. Chemical Communications (Cambridge, England). 51: 1532-4. PMID 25504318 DOI: 10.1039/C4Cc08753D  1
2015 Bordeaux M, Tyagi V, Fasan R. Enzyme-Catalyzed Cyclopropanation of Aryl-Substituted Olefins Synfacts. 11: 322-322. DOI: 10.1055/S-0034-1380065  1
2015 Bionda N, Fasan R. Peptidomimetics of α-Helical and β-Strand Protein Binding Epitopes Small Molecule Medicinal Chemistry: Strategies and Technologies. 431-464. DOI: 10.1002/9781118771723.ch15  1
2014 Fasan R. Natural, engineered, and artificial biocatalysts for organic synthesis. Bioorganic & Medicinal Chemistry. 22: 5537-8. PMID 25131959 DOI: 10.1016/J.Bmc.2014.07.039  1
2014 Bionda N, Cryan AL, Fasan R. Bioinspired strategy for the ribosomal synthesis of thioether-bridged macrocyclic peptides in bacteria. Acs Chemical Biology. 9: 2008-13. PMID 25079213 DOI: 10.1021/Cb500311K  1
2014 Bordeaux M, Singh R, Fasan R. Intramolecular C(sp(3))H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts. Bioorganic & Medicinal Chemistry. 22: 5697-704. PMID 24890656 DOI: 10.1016/J.Bmc.2014.05.015  1
2014 Smith JM, Frost JR, Fasan R. Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix. Chemical Communications (Cambridge, England). 50: 5027-30. PMID 24710524 DOI: 10.1039/C4Cc01199F  1
2014 Kolev JN, Zaengle JM, Ravikumar R, Fasan R. Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis. Chembiochem : a European Journal of Chemical Biology. 15: 1001-10. PMID 24692265 DOI: 10.1002/Cbic.201400060  1
2014 Singh R, Bordeaux M, Fasan R. P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates. Acs Catalysis. 4: 546-552. PMID 24634794 DOI: 10.1021/Cs400893N  1
2014 Smith JM, Hill NC, Krasniak PJ, Fasan R. Synthesis of bicyclic organo-peptide hybrids via oxime/intein-mediated macrocyclization followed by disulfide bond formation. Organic & Biomolecular Chemistry. 12: 1135-42. PMID 24395107 DOI: 10.1039/C3Ob42222D  1
2014 Kolev JN, O'Dwyer KM, Jordan CT, Fasan R. Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization. Acs Chemical Biology. 9: 164-73. PMID 24206617 DOI: 10.1021/Cb400626W  1
2014 Singh R, Bordeaux M, Fasan R. Biocatalytic Intramolecular C–H Amination Synfacts. 10: 434-434. DOI: 10.1055/S-0033-1341037  1
2013 Frost JR, Smith JM, Fasan R. Design, synthesis, and diversification of ribosomally derived peptide macrocycles. Current Opinion in Structural Biology. 23: 571-80. PMID 23856642 DOI: 10.1016/J.Sbi.2013.06.015  1
2013 Smith JM, Frost JR, Fasan R. Emerging strategies to access peptide macrocycles from genetically encoded polypeptides. The Journal of Organic Chemistry. 78: 3525-31. PMID 23517465 DOI: 10.1021/Jo400119S  1
2013 Frost JR, Vitali F, Jacob NT, Brown MD, Fasan R. Macrocyclization of organo-peptide hybrids through a dual bio-orthogonal ligation: insights from structure-reactivity studies. Chembiochem : a European Journal of Chemical Biology. 14: 147-60. PMID 23203912 DOI: 10.1002/Cbic.201200579  1
2013 Fasan R. Fingerprint-guided engineering of selective P450 catalysts for sp3 C-H functionalization in complex molecules 4th International Conference On Biomolecular Engineering, Icbe 2013. 19-35.  1
2012 Zhang K, Shafer BM, Demars MD, Stern HA, Fasan R. Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity. Journal of the American Chemical Society. 134: 18695-704. PMID 23121379 DOI: 10.1021/Ja3073462  1
2012 Satyanarayana M, Vitali F, Frost JR, Fasan R. Diverse organo-peptide macrocycles via a fast and catalyst-free oxime/intein-mediated dual ligation. Chemical Communications (Cambridge, England). 48: 1461-3. PMID 21897951 DOI: 10.1039/C1Cc13533C  1
2012 Fasan R. Tuning P450 enzymes as oxidation catalysts Acs Catalysis. 2: 647-666. DOI: 10.1021/Cs300001X  1
2011 Smith JM, Vitali F, Archer SA, Fasan R. Modular assembly of macrocyclic organo-peptide hybrids using synthetic and genetically encoded precursors. Angewandte Chemie (International Ed. in English). 50: 5075-80. PMID 21506227 DOI: 10.1002/Anie.201101331  1
2011 Zhang K, El Damaty S, Fasan R. P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity. Journal of the American Chemical Society. 133: 3242-5. PMID 21341707 DOI: 10.1021/Ja109590H  1
2011 Fasan R, Crook NC, Peters MW, Meinhold P, Buelter T, Landwehr M, Cirino PC, Arnold FH. Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli. Biotechnology and Bioengineering. 108: 500-10. PMID 21246504 DOI: 10.1002/Bit.22984  1
2009 Rentmeister A, Arnold FH, Fasan R. Chemo-enzymatic fluorination of unactivated organic compounds. Nature Chemical Biology. 5: 26-8. PMID 19011638 DOI: 10.1038/Nchembio.128  1
2008 Fasan R, Meharenna YT, Snow CD, Poulos TL, Arnold FH. Evolutionary history of a specialized p450 propane monooxygenase. Journal of Molecular Biology. 383: 1069-80. PMID 18619466 DOI: 10.1016/J.Jmb.2008.06.060  1
2007 Fasan R, Chen MM, Crook NC, Arnold FH. Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties. Angewandte Chemie (International Ed. in English). 46: 8414-8. PMID 17886313 DOI: 10.1002/Anie.200702616  1
2007 Fasan R, Arnold FH. Laboratory evolution of P450 alkane monooxygenases Acs National Meeting Book of Abstracts 1
2006 Fasan R, Dias RL, Moehle K, Zerbe O, Obrecht D, Mittl PR, Grütter MG, Robinson JA. Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction. Chembiochem : a European Journal of Chemical Biology. 7: 515-26. PMID 16511824 DOI: 10.1002/Cbic.200500452  1
2006 Dias RL, Fasan R, Moehle K, Renard A, Obrecht D, Robinson JA. Protein ligand design: from phage display to synthetic protein epitope mimetics in human antibody Fc-binding peptidomimetics. Journal of the American Chemical Society. 128: 2726-32. PMID 16492060 DOI: 10.1021/Ja057513W  1
2006 Auweter SD, Fasan R, Reymond L, Underwood JG, Black DL, Pitsch S, Allain FH. Molecular basis of RNA recognition by the human alternative splicing factor Fox-1. The Embo Journal. 25: 163-73. PMID 16362037 DOI: 10.1038/Sj.Emboj.7600918  1
2004 Fasan R, Dias RL, Moehle K, Zerbe O, Vrijbloed JW, Obrecht D, Robinson JA. Using a beta-hairpin to mimic an alpha-helix: cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction. Angewandte Chemie (International Ed. in English). 43: 2109-12. PMID 15083458 DOI: 10.1002/Anie.200353242  1
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