Ramanujan S. Hegde - Publications

Johns Hopkins University, Baltimore, MD 
Cell Biology, Biochemistry

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wan L, Juszkiewicz S, Blears D, Bajpe PK, Han Z, Faull P, Mitter R, Stewart A, Snijders AP, Hegde RS, Svejstrup JQ. Translation stress and collided ribosomes are co-activators of cGAS. Molecular Cell. PMID 34111399 DOI: 10.1016/j.molcel.2021.05.018  0.48
2020 Chitwood PJ, Hegde RS. An intramembrane chaperone complex facilitates membrane protein biogenesis. Nature. PMID 32814900 DOI: 10.1038/S41586-020-2624-Y  0.48
2020 Juszkiewicz S, Slodkowicz G, Lin Z, Freire-Pritchett P, Peak-Chew SY, Hegde RS. Ribosome collisions trigger cis-acting feedback inhibition of translation initiation. Elife. 9. PMID 32657267 DOI: 10.7554/Elife.60038  0.48
2020 Juszkiewicz S, Speldewinde SH, Wan L, Svejstrup JQ, Hegde RS. The ASC-1 Complex Disassembles Collided Ribosomes. Molecular Cell. PMID 32579943 DOI: 10.1016/J.Molcel.2020.06.006  0.48
2020 O'Donnell JP, Phillips BP, Yagita Y, Juszkiewicz S, Wagner A, Malinverni D, Keenan RJ, Miller EA, Hegde RS. The architecture of EMC reveals a path for membrane protein insertion. Elife. 9. PMID 32459176 DOI: 10.7554/Elife.57887  0.48
2020 Juszkiewicz S, Slodkowicz G, Lin Z, Freire-Pritchett P, Peak-Chew S, Hegde RS. Author response: Ribosome collisions trigger cis-acting feedback inhibition of translation initiation Elife. DOI: 10.7554/Elife.60038.Sa2  0.48
2020 O'Donnell JP, Phillips BP, Yagita Y, Juszkiewicz S, Wagner A, Malinverni D, Keenan RJ, Miller EA, Hegde RS. Author response: The architecture of EMC reveals a path for membrane protein insertion Elife. DOI: 10.7554/Elife.57887.Sa2  0.48
2019 Chandrasekaran V, Juszkiewicz S, Choi J, Puglisi JD, Brown A, Shao S, Ramakrishnan V, Hegde RS. Mechanism of ribosome stalling during translation of a poly(A) tail. Nature Structural & Molecular Biology. PMID 31768042 DOI: 10.1038/S41594-019-0331-X  1
2019 Lin Z, Gasic I, Chandrasekaran V, Peters N, Shao S, Mitchison TJ, Hegde RS. TTC5 mediates autoregulation of tubulin via mRNA degradation. Science (New York, N.Y.). PMID 31727855 DOI: 10.1126/Science.Aaz4352  1
2019 Verhagen JMA, van den Born M, van der Linde HC, Nikkels PGJ, Verdijk RM, Kivlen MH, van Unen LMA, Baas AF, Ter Heide H, van Osch-Gevers L, Hoogeveen-Westerveld M, Herkert JC, Bertoli-Avella AM, van Slegtenhorst MA, Wessels MW, ... ... Hegde RS, et al. Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy. Circulation. Genomic and Precision Medicine. PMID 31461301 DOI: 10.1161/CIRCGEN.119.002507  0.48
2019 Chitwood PJ, Hegde RS. The Role of EMC during Membrane Protein Biogenesis. Trends in Cell Biology. PMID 30826214 DOI: 10.1016/J.Tcb.2019.01.007  0.48
2019 Inglis AJ, Masson GR, Shao S, Perisic O, McLaughlin SH, Hegde RS, Williams RL. Activation of GCN2 by the ribosomal P-stalk. Proceedings of the National Academy of Sciences of the United States of America. PMID 30804176 DOI: 10.1073/Pnas.1813352116  1
2019 Volkmar N, Thezenas ML, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC. The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. Journal of Cell Science. 132. PMID 30578317 DOI: 10.1242/Jcs.223453  0.48
2018 Chitwood PJ, Juszkiewicz S, Guna A, Shao S, Hegde RS. EMC Is Required to Initiate Accurate Membrane Protein Topogenesis. Cell. PMID 30415835 DOI: 10.1016/J.Cell.2018.10.009  1
2018 Juszkiewicz S, Chandrasekaran V, Lin Z, Kraatz S, Ramakrishnan V, Hegde RS. ZNF598 Is a Quality Control Sensor of Collided Ribosomes. Molecular Cell. PMID 30293783 DOI: 10.1016/J.Molcel.2018.08.037  0.48
2018 Juszkiewicz S, Hegde RS. Quality Control of Orphaned Proteins. Molecular Cell. 71: 443-457. PMID 30075143 DOI: 10.1016/J.Molcel.2018.07.001  0.48
2018 Guna A, Hegde RS. Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control. Current Biology : Cb. 28: R498-R511. PMID 29689233 DOI: 10.1016/J.Cub.2018.02.004  0.48
2017 Guna A, Volkmar N, Christianson JC, Hegde RS. The ER membrane protein complex is a transmembrane domain insertase. Science (New York, N.Y.). PMID 29242231 DOI: 10.1126/Science.Aao3099  0.48
2017 Yanagitani K, Juszkiewicz S, Hegde RS. UBE2O is a quality control factor for orphans of multiprotein complexes. Science (New York, N.Y.). 357: 472-475. PMID 28774922 DOI: 10.1126/Science.Aan0178  0.48
2017 Shao S, Rodrigo-Brenni MC, Kivlen MH, Hegde RS. Mechanistic basis for a molecular triage reaction. Science (New York, N.Y.). 355: 298-302. PMID 28104892 DOI: 10.1126/Science.Aah6130  1
2017 Inglis AJ, Shao S, Masson GR, Perisic O, Hegde RS, Williams RL. Abstract A32: The role of the ribosome in GCN2's ability to sense amino acid deprivation and initiate the integrated stress response Cancer Research. 77. DOI: 10.1158/1538-7445.Transcontrol16-A32  1
2016 Juszkiewicz S, Hegde RS. Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. Molecular Cell. PMID 28065601 DOI: 10.1016/J.Molcel.2016.11.039  0.48
2016 Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS. Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell. 167: 1229-1240.e15. PMID 27863242 DOI: 10.1016/J.Cell.2016.10.046  1
2016 Itakura E, Zavodszky E, Shao S, Wohlever ML, Keenan RJ, Hegde RS. Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation. Molecular Cell. PMID 27345149 DOI: 10.1016/J.Molcel.2016.05.020  1
2016 Voorhees RM, Hegde RS. Toward a structural understanding of co-translational protein translocation. Current Opinion in Cell Biology. 41: 91-99. PMID 27155805 DOI: 10.1016/J.Ceb.2016.04.009  1
2016 Brandman O, Hegde RS. Ribosome-associated protein quality control. Nature Structural & Molecular Biology. 23: 7-15. PMID 26733220 DOI: 10.1038/Nsmb.3147  1
2016 Voorhees RM, Hegde RS. Structure of the Sec61 channel opened by a signal sequence. Science (New York, N.Y.). 351: 88-91. PMID 26721998 DOI: 10.1126/Science.Aad4992  1
2015 Shao S, Hegde RS. Target Selection during Protein Quality Control. Trends in Biochemical Sciences. PMID 26628391 DOI: 10.1016/J.Tibs.2015.10.007  1
2015 Brown A, Shao S, Murray J, Hegde RS, Ramakrishnan V. Structural basis for stop codon recognition in eukaryotes. Nature. 524: 493-6. PMID 26245381 DOI: 10.1038/Nature14896  1
2015 Voorhees RM, Hegde RS. Structures of the scanning and engaged states of the mammalian SRP-ribosome complex. Elife. 4. PMID 26158507 DOI: 10.7554/Elife.07975  1
2015 von der Malsburg K, Shao S, Hegde RS. The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon. Molecular Biology of the Cell. 26: 2168-80. PMID 25877867 DOI: 10.1091/Mbc.E15-01-0040  1
2015 Mateja A, Paduch M, Chang HY, Szydlowska A, Kossiakoff AA, Hegde RS, Keenan RJ. Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science (New York, N.Y.). 347: 1152-5. PMID 25745174 DOI: 10.1126/Science.1261671  1
2015 Shao S, Brown A, Santhanam B, Hegde RS. Structure and assembly pathway of the ribosome quality control complex. Molecular Cell. 57: 433-44. PMID 25578875 DOI: 10.1016/J.Molcel.2014.12.015  1
2015 Brown A, Shao S, Murray J, Hegde RS, Ramakrishnan V. Structural basis for stop codon recognition in eukaryotes Nature. 524: 493-496. DOI: 10.1038/nature14896  1
2014 Shao S, Hegde RS. Cell Biology. Local synthesis and disposal. Science (New York, N.Y.). 346: 701-2. PMID 25378608 DOI: 10.1126/Science.1261602  1
2014 Shao S, Hegde RS. Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors. Molecular Cell. 55: 880-90. PMID 25132172 DOI: 10.1016/J.Molcel.2014.07.006  1
2014 Satpute-Krishnan P, Ajinkya M, Bhat S, Itakura E, Hegde RS, Lippincott-Schwartz J. ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway. Cell. 158: 522-33. PMID 25083867 DOI: 10.1016/J.Cell.2014.06.026  1
2014 Rodrigo-Brenni MC, Gutierrez E, Hegde RS. Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6. Molecular Cell. 55: 227-37. PMID 24981174 DOI: 10.1016/J.Molcel.2014.05.025  1
2014 Voorhees RM, Fernández IS, Scheres SH, Hegde RS. Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution. Cell. 157: 1632-43. PMID 24930395 DOI: 10.1016/J.Cell.2014.05.024  1
2014 Hegde RS. Msp1: patrolling mitochondria for lost proteins. The Embo Journal. 33: 1509-10. PMID 24916308 DOI: 10.15252/Embj.201488930  1
2014 Chen C, Itakura E, Weber KP, Hegde RS, de Bono M. An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism. Plos Genetics. 10: e1004082. PMID 24603482 DOI: 10.1371/Journal.Pgen.1004082  1
2014 MacKinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J. An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate Elife. 2014. DOI: 10.7554/eLife.01483  1
2013 Zhang ZR, Bonifacino JS, Hegde RS. Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER. Cell. 154: 609-22. PMID 23890821 DOI: 10.1016/J.Cell.2013.06.038  1
2013 Shao S, von der Malsburg K, Hegde RS. Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation. Molecular Cell. 50: 637-48. PMID 23685075 DOI: 10.1016/J.Molcel.2013.04.015  1
2012 Rodrigo-Brenni MC, Hegde RS. Design principles of protein biosynthesis-coupled quality control. Developmental Cell. 23: 896-907. PMID 23153486 DOI: 10.1016/J.Devcel.2012.10.012  1
2012 Basseville A, Tamaki A, Ierano C, Trostel S, Ward Y, Robey RW, Hegde RS, Bates SE. Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter. Cancer Research. 72: 3642-51. PMID 22472121 DOI: 10.1158/0008-5472.Can-11-2008  1
2011 Shao S, Hegde RS. A calmodulin-dependent translocation pathway for small secretory proteins. Cell. 147: 1576-88. PMID 22196732 DOI: 10.1016/J.Cell.2011.11.048  1
2011 Hegde RS, Keenan RJ. Tail-anchored membrane protein insertion into the endoplasmic reticulum. Nature Reviews. Molecular Cell Biology. 12: 787-98. PMID 22086371 DOI: 10.1038/Nrm3226  1
2011 Maifeld SV, MacKinnon AL, Garrison JL, Sharma A, Kunkel EJ, Hegde RS, Taunton J. Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators. Chemistry & Biology. 18: 1082-8. PMID 21944747 DOI: 10.1016/J.Chembiol.2011.06.015  1
2011 Mariappan M, Mateja A, Dobosz M, Bove E, Hegde RS, Keenan RJ. The mechanism of membrane-associated steps in tail-anchored protein insertion. Nature. 477: 61-6. PMID 21866104 DOI: 10.1038/Nature10362  1
2011 Shao S, Hegde RS. Membrane protein insertion at the endoplasmic reticulum. Annual Review of Cell and Developmental Biology. 27: 25-56. PMID 21801011 DOI: 10.1146/Annurev-Cellbio-092910-154125  1
2011 Hessa T, Sharma A, Mariappan M, Eshleman HD, Gutierrez E, Hegde RS. Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature. 475: 394-7. PMID 21743475 DOI: 10.1038/Nature10181  1
2011 Shao S, Hegde RS. A flip turn for membrane protein insertion. Cell. 146: 13-5. PMID 21729778 DOI: 10.1016/J.Cell.2011.06.028  1
2011 Sherrill J, Mariappan M, Dominik P, Hegde RS, Keenan RJ. A conserved archaeal pathway for tail-anchored membrane protein insertion. Traffic (Copenhagen, Denmark). 12: 1119-23. PMID 21658170 DOI: 10.1111/J.1600-0854.2011.01229.X  1
2011 Wang Q, Liu Y, Soetandyo N, Baek K, Hegde R, Ye Y. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Molecular Cell. 42: 758-70. PMID 21636303 DOI: 10.1016/J.Molcel.2011.05.010  1
2011 Chakrabarti O, Rane NS, Hegde RS. Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins. Molecular Biology of the Cell. 22: 1625-37. PMID 21411629 DOI: 10.1091/Mbc.E10-07-0638  1
2011 Morimoto RI, Driessen AJ, Hegde RS, Langer T. The life of proteins: the good, the mostly good and the ugly. Nature Structural & Molecular Biology. 18: 1-4. PMID 21209622 DOI: 10.1038/Nsmb0111-1  1
2010 Emerman AB, Zhang ZR, Chakrabarti O, Hegde RS. Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo. Molecular Biology of the Cell. 21: 4325-37. PMID 20980618 DOI: 10.1091/Mbc.E10-09-0742  1
2010 Mariappan M, Li X, Stefanovic S, Sharma A, Mateja A, Keenan RJ, Hegde RS. A ribosome-associating factor chaperones tail-anchored membrane proteins. Nature. 466: 1120-4. PMID 20676083 DOI: 10.1038/Nature09296  1
2010 Hegde RS, Ploegh HL. Quality and quantity control at the endoplasmic reticulum. Current Opinion in Cell Biology. 22: 437-46. PMID 20570125 DOI: 10.1016/J.Ceb.2010.05.005  1
2010 Rutkowski DT, Hegde RS. Regulation of basal cellular physiology by the homeostatic unfolded protein response. The Journal of Cell Biology. 189: 783-94. PMID 20513765 DOI: 10.1083/Jcb.201003138  1
2010 Sharma A, Mariappan M, Appathurai S, Hegde RS. In vitro dissection of protein translocation into the mammalian endoplasmic reticulum. Methods in Molecular Biology (Clifton, N.J.). 619: 339-63. PMID 20419420 DOI: 10.1007/978-1-60327-412-8_20  1
2010 Rane NS, Chakrabarti O, Feigenbaum L, Hegde RS. Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein. The Journal of Cell Biology. 188: 515-26. PMID 20156965 DOI: 10.1083/Jcb.200911115  1
2009 Mateja A, Szlachcic A, Downing ME, Dobosz M, Mariappan M, Hegde RS, Keenan RJ. The structural basis of tail-anchored membrane protein recognition by Get3. Nature. 461: 361-6. PMID 19675567 DOI: 10.1038/Nature08319  1
2009 Ashok A, Hegde RS. Selective processing and metabolism of disease-causing mutant prion proteins. Plos Pathogens. 5: e1000479. PMID 19543376 DOI: 10.1371/Journal.Ppat.1000479  1
2009 Chakrabarti O, Hegde RS. Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. Cell. 137: 1136-47. PMID 19524515 DOI: 10.1016/J.Cell.2009.03.042  1
2009 Chakrabarti O, Ashok A, Hegde RS. Prion protein biosynthesis and its emerging role in neurodegeneration. Trends in Biochemical Sciences. 34: 287-95. PMID 19447626 DOI: 10.1016/J.Tibs.2009.03.001  1
2009 Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE. Arginine 383 is a crucial residue in ABCG2 biogenesis. Biochimica Et Biophysica Acta. 1788: 1434-43. PMID 19406100 DOI: 10.1016/J.Bbamem.2009.04.016  1
2009 Hegde RS. Protein Maturation and Processing at the Endoplasmic Reticulum The Liver: Biology and Pathobiology: Fifth Edition. 157-171. DOI: 10.1002/9781119436812.Ch10  1
2008 Kang SW, Hegde RS. Lighting up the stressed ER. Cell. 135: 787-9. PMID 19041740 DOI: 10.1016/J.Cell.2008.11.004  1
2008 Rane NS, Kang SW, Chakrabarti O, Feigenbaum L, Hegde RS. Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration. Developmental Cell. 15: 359-70. PMID 18804434 DOI: 10.1016/J.Devcel.2008.06.015  1
2008 Hegde RS, Kang SW. The concept of translocational regulation. The Journal of Cell Biology. 182: 225-32. PMID 18644895 DOI: 10.1083/Jcb.200804157  1
2008 Ashok A, Hegde RS. Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation. Molecular Biology of the Cell. 19: 3463-76. PMID 18508914 DOI: 10.1091/Mbc.E08-01-0087  1
2007 MacKinnon AL, Garrison JL, Hegde RS, Taunton J. Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. Journal of the American Chemical Society. 129: 14560-1. PMID 17983236 DOI: 10.1021/Ja076250Y  1
2007 Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS. The role of p58IPK in protecting the stressed endoplasmic reticulum. Molecular Biology of the Cell. 18: 3681-91. PMID 17567950 DOI: 10.1091/Mbc.E07-03-0272  1
2007 Stefanovic S, Hegde RS. Identification of a targeting factor for posttranslational membrane protein insertion into the ER. Cell. 128: 1147-59. PMID 17382883 DOI: 10.1016/J.Cell.2007.01.036  1
2007 Ong HL, Liu X, Tsaneva-Atanasova K, Singh BB, Bandyopadhyay BC, Swaim WD, Russell JT, Hegde RS, Sherman A, Ambudkar IS. Relocalization of STIM1 for activation of store-operated Ca(2+) entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca(2+) store. The Journal of Biological Chemistry. 282: 12176-85. PMID 17298947 DOI: 10.1074/Jbc.M609435200  1
2007 Ong HL, Liu X, Sharma A, Hegde RS, Ambudkar IS. Intracellular Ca(2+) release via the ER translocon activates store-operated calcium entry. PflüGers Archiv : European Journal of Physiology. 453: 797-808. PMID 17171366 DOI: 10.1007/S00424-006-0163-5  1
2007 Alken M, Hegde RS. The Translocation Apparatus of the Endoplasmic Reticulum Enzymes. 25: 207-243. DOI: 10.1016/S1874-6047(07)25009-7  1
2007 Chakrabarti O, Hegde RS. Trafficking of the Cellular Prion Protein and Its Role in Neurodegeneration Protein Trafficking in Neurons. 413-435. DOI: 10.1016/B978-012369437-9/50026-8  1
2006 Snapp EL, Hegde RS. Rational design and evaluation of FRET experiments to measure protein proximities in cells. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 17.9. PMID 18228480 DOI: 10.1002/0471143030.Cb1709S32  1
2006 Kang SW, Rane NS, Kim SJ, Garrison JL, Taunton J, Hegde RS. Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell. 127: 999-1013. PMID 17129784 DOI: 10.1016/J.Cell.2006.10.032  1
2006 Hegde RS, Bernstein HD. The surprising complexity of signal sequences. Trends in Biochemical Sciences. 31: 563-71. PMID 16919958 DOI: 10.1016/J.Tibs.2006.08.004  1
2006 Ashok A, Hegde RS. Prions and retroviruses: an endosomal rendezvous? Embo Reports. 7: 685-7. PMID 16819462 DOI: 10.1038/Sj.Embor.7400749  1
2006 Snapp EL, Sharma A, Lippincott-Schwartz J, Hegde RS. Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells Proceedings of the National Academy of Sciences of the United States of America. 103: 6536-6541. PMID 16617114 DOI: 10.1073/Pnas.0510657103  1
2005 Shaffer KL, Sharma A, Snapp EL, Hegde RS. Regulation of protein compartmentalization expands the diversity of protein function. Developmental Cell. 9: 545-54. PMID 16198296 DOI: 10.1016/J.Devcel.2005.09.001  1
2005 Garrison JL, Kunkel EJ, Hegde RS, Taunton J. A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature. 436: 285-9. PMID 16015336 DOI: 10.1038/Nature03821  1
2005 Brambillasca S, Yabal M, Soffientini P, Stefanovic S, Makarow M, Hegde RS, Borgese N. Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition. The Embo Journal. 24: 2533-42. PMID 15973434 DOI: 10.1038/Sj.Emboj.7600730  1
2005 Levine CG, Mitra D, Sharma A, Smith CL, Hegde RS. The efficiency of protein compartmentalization into the secretory pathway. Molecular Biology of the Cell. 16: 279-91. PMID 15496459 DOI: 10.1091/Mbc.E04-06-0508  1
2005 Hegde RS, Rane NS. The molecular basis of prion protein-mediated neuronal damage Neurodegeneration and Prion Disease. 407-450. DOI: 10.1007/0-387-23923-5_16  1
2004 Rane NS, Yonkovich JL, Hegde RS. Protection from cytosolic prion protein toxicity by modulation of protein translocation. The Embo Journal. 23: 4550-9. PMID 15526034 DOI: 10.1038/Sj.Emboj.7600462  1
2004 Karsten V, Hegde RS, Sinai AP, Yang M, Joiner KA. Transmembrane domain modulates sorting of membrane proteins in Toxoplasma gondii. The Journal of Biological Chemistry. 279: 26052-7. PMID 15056659 DOI: 10.1074/Jbc.M400480200  1
2004 Snapp EL, Reinhart GA, Bogert BA, Lippincott-Schwartz J, Hegde RS. The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells. The Journal of Cell Biology. 164: 997-1007. PMID 15051734 DOI: 10.1083/Jcb.200312079  1
2004 Tremblay P, Ball HL, Kaneko K, Groth D, Hegde RS, Cohen FE, DeArmond SJ, Prusiner SB, Safar JG. Mutant PrPSc conformers induced by a synthetic peptide and several prion strains. Journal of Virology. 78: 2088-99. PMID 14747574 DOI: 10.1128/Jvi.78.4.2088-2099.2004  1
2003 Snapp EL, Hegde RS, Francolini M, Lombardo F, Colombo S, Pedrazzini E, Borgese N, Lippincott-Schwartz J. Formation of stacked ER cisternae by low affinity protein interactions. The Journal of Cell Biology. 163: 257-69. PMID 14581454 DOI: 10.1083/Jcb.200306020  1
2003 Hegde RS, Rane NS. Prion protein trafficking and the development of neurodegeneration. Trends in Neurosciences. 26: 337-9. PMID 12850426 DOI: 10.1016/S0166-2236(03)00143-7  1
2003 Fons RD, Bogert BA, Hegde RS. Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane. The Journal of Cell Biology. 160: 529-39. PMID 12578908 DOI: 10.1083/Jcb.200210095  1
2002 Kim SJ, Hegde RS. Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel. Molecular Biology of the Cell. 13: 3775-86. PMID 12429823 DOI: 10.1091/Mbc.E02-05-0293  1
2002 Hegde RS. Targeting and beyond: new roles for old signal sequences. Molecular Cell. 10: 697-8. PMID 12419211 DOI: 10.1016/S1097-2765(02)00692-5  1
2002 Lingappa VR, Rutkowski DT, Hegde RS, Andersen OS. Conformational control through translocational regulation: a new view of secretory and membrane protein folding. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 24: 741-8. PMID 12210535 DOI: 10.1002/Bies.10130  1
2002 Kim SJ, Mitra D, Salerno JR, Hegde RS. Signal sequences control gating of the protein translocation channel in a substrate-specific manner. Developmental Cell. 2: 207-17. PMID 11832246 DOI: 10.1016/S1534-5807(01)00120-4  1
2001 Rutkowski DT, Lingappa VR, Hegde RS. Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequences. Proceedings of the National Academy of Sciences of the United States of America. 98: 7823-8. PMID 11416167 DOI: 10.1073/Pnas.141125098  1
2001 Kim SJ, Rahbar R, Hegde RS. Combinatorial Control of Prion Protein Biogenesis by the Signal Sequence and Transmembrane Domain Journal of Biological Chemistry. 276: 26132-26140. PMID 11359769 DOI: 10.1074/Jbc.M101638200  1
2000 Wilhelm JE, Vale RD, Hegde RS. Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 97: 13132-7. PMID 11087864 DOI: 10.1073/Pnas.97.24.13132  1
1999 Hegde RS, Tremblay P, Groth D, DeArmond SJ, Prusiner SB, Lingappa VR. Transmissible and genetic prion diseases share a common pathway of neurodegeneration. Nature. 402: 822-6. PMID 10617204 DOI: 10.1038/45574  1
1999 Hegde RS, Lingappa VR. Regulation of protein biogenesis at the endoplasmic reticulum membrane. Trends in Cell Biology. 9: 132-7. PMID 10203789 DOI: 10.1016/S0962-8924(99)01504-4  1
1998 Hegde RS, Voigt S, Lingappa VR. Regulation of protein topology by trans-acting factors at the endoplasmic reticulum. Molecular Cell. 2: 85-91. PMID 9702194 DOI: 10.1016/S1097-2765(00)80116-1  1
1998 Rusiñol AE, Hegde RS, Chuck SL, Lingappa VR, Vance JE. Translocational pausing of apolipoprotein B can be regulated by membrane lipid composition. Journal of Lipid Research. 39: 1287-94. PMID 9643361  1
1998 Hegde RS, Voigt S, Rapoport TA, Lingappa VR. TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum. Cell. 92: 621-31. PMID 9506517 DOI: 10.1016/S0092-8674(00)81130-7  1
1998 Hegde RS, Mastrianni JA, Scott MR, DeFea KA, Tremblay P, Torchia M, DeArmond SJ, Prusiner SB, Lingappa VR. A transmembrane form of the prion protein in neurodegenerative disease. Science (New York, N.Y.). 279: 827-34. PMID 9452375 DOI: 10.1126/Science.279.5352.827  1
1997 Hegde RS, Lingappa VR. Membrane protein biogenesis: regulated complexity at the endoplasmic reticulum. Cell. 91: 575-82. PMID 9393851 DOI: 10.1016/S0092-8674(00)80445-6  1
1997 Kivlen MH, Dorsey CA, Lingappa VR, Hegde RS. Asymmetric distribution of pause transfer sequences in apolipoprotein B-100. Journal of Lipid Research. 38: 1149-62. PMID 9215543  1
1997 Lingappa JR, Hill RL, Wong ML, Hegde RS. A multistep, ATP-dependent pathway for assembly of human immunodeficiency virus capsids in a cell-free system. The Journal of Cell Biology. 136: 567-81. PMID 9024688 DOI: 10.1083/Jcb.136.3.567  1
1996 Hegde RS, Lingappa VR. Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol. Cell. 85: 217-28. PMID 8612274 DOI: 10.1016/S0092-8674(00)81098-3  1
1995 Hegde RS, Zuo J, Voellmy R, Welch WJ. Short circuiting stress protein expression via a tyrosine kinase inhibitor, Herbimycin A Journal of Cellular Physiology. 165: 186-200. PMID 7559801 DOI: 10.1002/Jcp.1041650122  1
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