Grzegorz W. Bulaj - Publications

Affiliations: 
Medicinal Chemistry University of Utah, Salt Lake City, UT 
Area:
Pharmaceutical Chemistry, Biochemistry, Neuroscience Biology

92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Walls AB, Flynn SP, West PJ, Müller MS, Bak LK, Bulaj G, Schousboe A, White HS. The anticonvulsant action of the galanin receptor agonist NAX-5055 involves modulation of both excitatory- and inhibitory neurotransmission. Epilepsy Research. 121: 55-63. PMID 26894875 DOI: 10.1016/J.Eplepsyres.2016.01.006  0.52
2016 Green BR, Gajewiak J, Chhabra S, Skalicky JJ, Zhang MM, Rivier JE, Bulaj G, Olivera BM, Yoshikami D, Norton RS. Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. The Journal of Biological Chemistry. PMID 26817840 DOI: 10.1074/Jbc.M115.697672  0.52
2015 Zhang MM, Gajewiak J, Azam L, Bulaj G, Olivera BM, Yoshikami D. Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ. Biochemistry. 54: 3911-20. PMID 26039939 DOI: 10.1021/Acs.Biochem.5B00390  0.36
2015 Lee HK, Zhang L, Smith MD, Walewska A, Vellore NA, Baron R, McIntosh JM, White HS, Olivera BM, Bulaj G. A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties. Frontiers in Pharmacology. 6: 11. PMID 25713532 DOI: 10.3389/Fphar.2015.00011  0.52
2015 Metcalf CS, Klein BD, McDougle DR, Zhang L, Smith MD, Bulaj G, White HS. Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models. The Journal of Pharmacology and Experimental Therapeutics. 352: 185-93. PMID 25347995 DOI: 10.1124/Jpet.114.219063  0.52
2015 Zhang MM, Gajewiak J, Azam L, Bulaj G, Olivera BM, Yoshikami D. Probing the Redox States of Sodium Channel Cysteines at the Binding Site of μO§-Conotoxin GVIIJ Biochemistry. 54: 3911-3920. DOI: 10.1021/acs.biochem.5b00390  0.52
2015 Teichert RW, Olivera BM, Michael McIntosh J, Bulaj G, Horvath MP. The molecular diversity of conoidean venom peptides and their targets: From basic research to therapeutic applications Rsc Drug Discovery Series. 2015: 163-203.  0.52
2014 Green BR, Zhang MM, Chhabra S, Robinson SD, Wilson MJ, Redding A, Olivera BM, Yoshikami D, Bulaj G, Norton RS. Interactions of disulfide-deficient selenocysteine analogs of μ-conotoxin BuIIIB with the α-subunit of the voltage-gated sodium channel subtype 1.3. The Febs Journal. 281: 2885-98. PMID 24814369 DOI: 10.1111/Febs.12835  0.52
2014 Platt RJ, Curtice KJ, Twede VD, Watkins M, Gruszczy?ski P, Bulaj G, Horvath MP, Olivera BM. From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon : Official Journal of the International Society On Toxinology. 81: 67-79. PMID 24508768 DOI: 10.1016/J.Toxicon.2014.01.016  0.52
2014 Gajewiak J, Azam L, Imperial J, Walewska A, Green BR, Bandyopadhyay PK, Raghuraman S, Ueberheide B, Bern M, Zhou HM, Minassian NA, Hagan RH, Flinspach M, Liu Y, Bulaj G, et al. A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ. Proceedings of the National Academy of Sciences of the United States of America. 111: 2758-63. PMID 24497506 DOI: 10.1073/Pnas.1324189111  0.52
2013 Steiner AM, Bulaj G, Puillandre N. On the importance of oxidative folding in the evolution of conotoxins: cysteine codon preservation through gene duplication and adaptation. Plos One. 8: e78456. PMID 24244311 DOI: 10.1371/Journal.Pone.0078456  0.52
2013 Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G, Norton RS. Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency. Acs Chemical Biology. 8: 1344-51. PMID 23557677 DOI: 10.1021/Cb300674X  0.52
2013 Zhang MM, Wilson MJ, Gajewiak J, Rivier JE, Bulaj G, Olivera BM, Yoshikami D. Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxins. British Journal of Pharmacology. 169: 102-14. PMID 23351163 DOI: 10.1111/Bph.12119  0.52
2013 Zhang L, Klein BD, Metcalf CS, Smith MD, McDougle DR, Lee HK, White HS, Bulaj G. Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics. Molecular Pharmaceutics. 10: 574-85. PMID 23259957 DOI: 10.1021/Mp300236V  0.52
2013 Green BR, Klein BD, Lee HK, Smith MD, Steve White H, Bulaj G. Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling. Bioorganic & Medicinal Chemistry. 21: 303-10. PMID 23176753 DOI: 10.1016/J.Bmc.2012.10.026  0.52
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.36
2013 Zhang MM, Wilson MJ, Azam L, Gajewiak J, Rivier JE, Bulaj G, Olivera BM, Yoshikami D. Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins. British Journal of Pharmacology. 168: 1597-610. PMID 23146020 DOI: 10.1111/Bph.12051  0.52
2013 Caldwell C, Bruggers C, Altizer R, Bulaj G, D'Ambrosio T, Kessler R, Christiansen B. The intersection of video games and patient empowerment: Case study of a real world application Acm International Conference Proceeding Series. DOI: 10.1145/2513002.2513018  0.52
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A  0.36
2012 Khoo KK, Gupta K, Green BR, Zhang MM, Watkins M, Olivera BM, Balaram P, Yoshikami D, Bulaj G, Norton RS. Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels. Biochemistry. 51: 9826-35. PMID 23167564 DOI: 10.1021/Bi301256S  0.52
2012 Bruggers CS, Altizer RA, Kessler RR, Caldwell CB, Coppersmith K, Warner L, Davies B, Paterson W, Wilcken J, D'Ambrosio TA, German ML, Hanson GR, Gershan LA, Korenberg JR, Bulaj G. Patient-empowerment interactive technologies. Science Translational Medicine. 4: 152ps16. PMID 22993292 DOI: 10.1126/Scitranslmed.3004009  0.52
2012 Safavi-Hemami H, Gorasia DG, Steiner AM, Williamson NA, Karas JA, Gajewiak J, Olivera BM, Bulaj G, Purcell AW. Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails. The Journal of Biological Chemistry. 287: 34288-303. PMID 22891240 DOI: 10.1074/Jbc.M112.366781  0.52
2012 Gowd KH, Blais KD, Elmslie KS, Steiner AM, Olivera BM, Bulaj G. Dissecting a role of evolutionary-conserved but noncritical disulfide bridges in cysteine-rich peptides using ω-conotoxin GVIA and its selenocysteine analogs. Biopolymers. 98: 212-23. PMID 22782563 DOI: 10.1002/Bip.22047  0.52
2012 Singer HM, Erhardt M, Steiner AM, Zhang MM, Yoshikami D, Bulaj G, Olivera BM, Hughes KT. Selective purification of recombinant neuroactive peptides using the flagellar type III secretion system. Mbio. 3. PMID 22647788 DOI: 10.1128/Mbio.00115-12  0.52
2012 Gowd KH, Han TS, Twede V, Gajewiak J, Smith MD, Watkins M, Platt RJ, Toledo G, White HS, Olivera BM, Bulaj G. Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry. 51: 4685-92. PMID 22594498 DOI: 10.1021/Bi300055N  0.52
2012 Platt RJ, Han TS, Green BR, Smith MD, Skalicky J, Gruszczynski P, White HS, Olivera B, Bulaj G, Gajewiak J. Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. The Journal of Biological Chemistry. 287: 20727-36. PMID 22518838 DOI: 10.1074/Jbc.M112.350462  0.52
2012 Steiner AM, Woycechowsky KJ, Olivera BM, Bulaj G. Reagentless oxidative folding of disulfide-rich peptides catalyzed by an intramolecular diselenide. Angewandte Chemie (International Ed. in English). 51: 5580-4. PMID 22454362 DOI: 10.1002/Anie.201200062  0.52
2012 Robertson CR, Pruess TH, Grussendorf E, White HS, Bulaj G. Generating orally active galanin analogues with analgesic activities. Chemmedchem. 7: 903-9. PMID 22374865 DOI: 10.1002/Cmdc.201100574  0.52
2011 Green BR, Smith M, White KL, White HS, Bulaj G. Analgesic neuropeptide W suppresses seizures in the brain revealed by rational repositioning and peptide engineering. Acs Chemical Neuroscience. 2: 51-6. PMID 22826747 DOI: 10.1021/Cn1000974  0.52
2011 Wilson MJ, Yoshikami D, Azam L, Gajewiak J, Olivera BM, Bulaj G, Zhang MM. μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve. Proceedings of the National Academy of Sciences of the United States of America. 108: 10302-7. PMID 21652775 DOI: 10.1073/Pnas.1107027108  0.52
2011 Wilson MJ, Zhang MM, Azam L, Olivera BM, Bulaj G, Yoshikami D. Navβ subunits modulate the inhibition of Nav1.8 by the analgesic gating modifier μO-conotoxin MrVIB. The Journal of Pharmacology and Experimental Therapeutics. 338: 687-93. PMID 21586605 DOI: 10.1124/Jpet.110.178343  0.52
2011 Robertson CR, Flynn SP, White HS, Bulaj G. Anticonvulsant neuropeptides as drug leads for neurological diseases. Natural Product Reports. 28: 741-62. PMID 21340067 DOI: 10.1039/C0Np00048E  0.52
2011 Steiner AM, Bulaj G. Optimization of oxidative folding methods for cysteine-rich peptides: a study of conotoxins containing three disulfide bridges. Journal of Peptide Science : An Official Publication of the European Peptide Society. 17: 1-7. PMID 20814907 DOI: 10.1002/Psc.1283  0.52
2010 McIntosh JA, Robertson CR, Agarwal V, Nair SK, Bulaj GW, Schmidt EW. Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst. Journal of the American Chemical Society. 132: 15499-501. PMID 20961047 DOI: 10.1021/Ja1067806  0.52
2010 Han TS, Zhang MM, Gowd KH, Walewska A, Yoshikami D, Olivera BM, Bulaj G. Disulfide-Depleted Selenoconopeptides: a Minimalist Strategy to Oxidative Folding of Cysteine-Rich Peptides. Acs Medicinal Chemistry Letters. 1: 140-144. PMID 20676359 DOI: 10.1021/Ml900017Q  0.36
2010 Green BR, White KL, McDougle DR, Zhang L, Klein B, Scholl EA, Pruess TH, White HS, Bulaj G. Introduction of lipidization-cationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 486-95. PMID 20645434 DOI: 10.1002/Psc.1266  0.52
2010 Gowd KH, Watkins M, Twede VD, Bulaj GW, Olivera BM. Characterization of conantokin Rl-A: molecular phylogeny as structure/function study. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 375-82. PMID 20572027 DOI: 10.1002/Psc.1249  0.52
2010 Zhang MM, Han TS, Olivera BM, Bulaj G, Yoshikami D. μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels. Biochemistry. 49: 4804-12. PMID 20459109 DOI: 10.1021/Bi100207K  0.52
2010 Zhang MM, Gruszczynski P, Walewska A, Bulaj G, Olivera BM, Yoshikami D. Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin. Journal of Neurophysiology. 104: 88-97. PMID 20410356 DOI: 10.1152/Jn.00145.2010  0.52
2010 Gowd KH, Yarotskyy V, Elmslie KS, Skalicky JJ, Olivera BM, Bulaj G. Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA. Biochemistry. 49: 2741-52. PMID 20175537 DOI: 10.1021/Bi902137C  0.52
2010 Safavi-Hemami H, Bulaj G, Olivera BM, Williamson NA, Purcell AW. Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins. The Journal of Biological Chemistry. 285: 12735-46. PMID 20147296 DOI: 10.1074/Jbc.M109.078691  0.52
2010 Robertson CR, Scholl EA, Pruess TH, Green BR, White HS, Bulaj G. Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery. Journal of Medicinal Chemistry. 53: 1871-5. PMID 20121116 DOI: 10.1021/Jm9018349  0.52
2010 Han TS, Zhang MM, Gowd KH, Walewska A, Yoshikami D, Olivera BM, Bulaj G. Disulfide-depleted selenoconopeptides: Simplified oxidative folding of cysteine-rich peptides Acs Medicinal Chemistry Letters. 1: 140-144. DOI: 10.1021/ml900017q  0.52
2009 Lee HK, Smith MD, Smith BJ, Grussendorf J, Xu L, Gillies RJ, White HS, Bulaj G. Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain. Acs Chemical Biology. 4: 659-71. PMID 19634861 DOI: 10.1021/Cb900045C  0.52
2009 White HS, Scholl EA, Klein BD, Flynn SP, Pruess TH, Green BR, Zhang L, Bulaj G. Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 372-80. PMID 19332332 DOI: 10.1016/J.Nurt.2009.01.001  0.52
2009 Twede VD, Teichert RW, Walker CS, Gruszczy?ski P, Ka?mierkiewicz R, Bulaj G, Olivera BM. Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry. 48: 4063-73. PMID 19309162 DOI: 10.1021/Bi802259A  0.52
2009 Zhang L, Lee HK, Pruess TH, White HS, Bulaj G. Synthesis and applications of polyamine amino acid residues: improving the bioactivity of an analgesic neuropeptide, neurotensin. Journal of Medicinal Chemistry. 52: 1514-7. PMID 19236044 DOI: 10.1021/Jm801481Y  0.52
2009 Zhang MM, McArthur JR, Azam L, Bulaj G, Olivera BM, French RJ, Yoshikami D. Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. Channels (Austin, Tex.). 3: 32-8. PMID 19221510 DOI: 10.4161/Chan.3.1.7500  0.52
2009 Walewska A, Zhang MM, Skalicky JJ, Yoshikami D, Olivera BM, Bulaj G. Integrated oxidative folding of cysteine/selenocysteine containing peptides: improving chemical synthesis of conotoxins. Angewandte Chemie (International Ed. in English). 48: 2221-4. PMID 19206132 DOI: 10.1002/Anie.200806085  0.52
2009 Zhang L, Robertson CR, Green BR, Pruess TH, White HS, Bulaj G. Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. Journal of Medicinal Chemistry. 52: 1310-6. PMID 19199479 DOI: 10.1021/Jm801397W  0.52
2009 Lee HK, Zhang L, Smith MD, White HS, Bulaj G. Glycosylated neurotensin analogues exhibit sub-picomolar anticonvulsant potency in a pharmacoresistant model of epilepsy. Chemmedchem. 4: 400-5. PMID 19173215 DOI: 10.1002/Cmdc.200800421  0.52
2009 Khoo KK, Feng ZP, Smith BJ, Zhang MM, Yoshikami D, Olivera BM, Bulaj G, Norton RS. Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry. 48: 1210-9. PMID 19170536 DOI: 10.1021/Bi801998A  0.52
2009 Han TS, Zhang MM, Walewska A, Gruszczynski P, Robertson CR, Cheatham TE, Yoshikami D, Olivera BM, Bulaj G. Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics. Chemmedchem. 4: 406-14. PMID 19107760 DOI: 10.1002/Cmdc.200800292  0.52
2009 Holford M, Zhang MM, Gowd KH, Azam L, Green BR, Watkins M, Ownby JP, Yoshikami D, Bulaj G, Olivera BM. Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon : Official Journal of the International Society On Toxinology. 53: 90-8. PMID 18950653 DOI: 10.1016/J.Toxicon.2008.10.017  0.52
2008 Bulaj G, Green BR, Lee HK, Robertson CR, White K, Zhang L, Sochanska M, Flynn SP, Scholl EA, Pruess TH, Smith MD, White HS. Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities. Journal of Medicinal Chemistry. 51: 8038-47. PMID 19053761 DOI: 10.1021/Jm801088X  0.52
2008 Walewska A, Skalicky JJ, Davis DR, Zhang MM, Lopez-Vera E, Watkins M, Han TS, Yoshikami D, Olivera BM, Bulaj G. NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA. Journal of the American Chemical Society. 130: 14280-6. PMID 18831583 DOI: 10.1021/Ja804303P  0.52
2008 Yao S, Zhang MM, Yoshikami D, Azam L, Olivera BM, Bulaj G, Norton RS. Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA. Biochemistry. 47: 10940-9. PMID 18798648 DOI: 10.1021/Bi801010U  0.52
2008 Han TS, Teichert RW, Olivera BM, Bulaj G. Conus venoms - a rich source of peptide-based therapeutics. Current Pharmaceutical Design. 14: 2462-79. PMID 18781995 DOI: 10.2174/138161208785777469  0.52
2008 Gowd KH, Twede V, Watkins M, Krishnan KS, Teichert RW, Bulaj G, Olivera BM. Conantokin-P, an unusual conantokin with a long disulfide loop. Toxicon : Official Journal of the International Society On Toxinology. 52: 203-13. PMID 18586049 DOI: 10.1016/J.Toxicon.2008.04.178  0.52
2008 Fiedler B, Zhang MM, Buczek O, Azam L, Bulaj G, Norton RS, Olivera BM, Yoshikami D. Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochemical Pharmacology. 75: 2334-44. PMID 18486102 DOI: 10.1016/J.Bcp.2008.03.019  0.52
2008 Lopez-Vera E, Walewska A, Skalicky JJ, Olivera BM, Bulaj G. Role of hydroxyprolines in the in vitro oxidative folding and biological activity of conotoxins. Biochemistry. 47: 1741-51. PMID 18189422 DOI: 10.1021/Bi701934M  0.52
2008 Lluisma AO, López-Vera E, Bulaj G, Watkins M, Olivera BM. Characterization of a novel psi-conotoxin from Conus parius Reeve. Toxicon : Official Journal of the International Society On Toxinology. 51: 174-80. PMID 18054976 DOI: 10.1016/J.Toxicon.2007.07.009  0.52
2008 Bulaj G, Olivera BM. Folding of conotoxins: formation of the native disulfide bridges during chemical synthesis and biosynthesis of Conus peptides. Antioxidants & Redox Signaling. 10: 141-55. PMID 17961068 DOI: 10.1089/Ars.2007.1856  0.52
2007 Teichert RW, Jimenez EC, Twede V, Watkins M, Hollmann M, Bulaj G, Olivera BM. Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 282: 36905-13. PMID 17962189 DOI: 10.1074/Jbc.M706611200  0.52
2007 Zhang MM, Green BR, Catlin P, Fiedler B, Azam L, Chadwick A, Terlau H, McArthur JR, French RJ, Gulyas J, Rivier JE, Smith BJ, Norton RS, Olivera BM, Yoshikami D, ... Bulaj G, et al. Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. The Journal of Biological Chemistry. 282: 30699-706. PMID 17724025 DOI: 10.1074/Jbc.M704616200  0.52
2007 Buczek O, Wei D, Babon JJ, Yang X, Fiedler B, Chen P, Yoshikami D, Olivera BM, Bulaj G, Norton RS. Structure and sodium channel activity of an excitatory I1-superfamily conotoxin. Biochemistry. 46: 9929-40. PMID 17696362 DOI: 10.1021/Bi701925D  0.52
2007 Green BR, Catlin P, Zhang MM, Fiedler B, Bayudan W, Morrison A, Norton RS, Smith BJ, Yoshikami D, Olivera BM, Bulaj G. Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity. Chemistry & Biology. 14: 399-407. PMID 17462575 DOI: 10.1016/J.Chembiol.2007.02.009  0.52
2006 Dy CY, Buczek P, Imperial JS, Bulaj G, Horvath MP. Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail. Acta Crystallographica. Section D, Biological Crystallography. 62: 980-90. PMID 16929098 DOI: 10.1107/S0907444906021123  0.52
2006 Bulaj G, Zhang MM, Green BR, Fiedler B, Layer RT, Wei S, Nielsen JS, Low SJ, Klein BD, Wagstaff JD, Chicoine L, Harty TP, Terlau H, Yoshikami D, Olivera BM. Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity. Biochemistry. 45: 7404-14. PMID 16752929 DOI: 10.1021/Bi060159+  0.52
2006 Zhang MM, Fiedler B, Green BR, Catlin P, Watkins M, Garrett JE, Smith BJ, Yoshikami D, Olivera BM, Bulaj G. Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels. Biochemistry. 45: 3723-32. PMID 16533055 DOI: 10.1021/Bi052162J  0.52
2006 Zorn S, Leipold E, Hansel A, Bulaj G, Olivera BM, Terlau H, Heinemann SH. The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3. Febs Letters. 580: 1360-4. PMID 16458302 DOI: 10.1016/J.Febslet.2006.01.057  0.52
2005 Buczek O, Bulaj G, Olivera BM. Conotoxins and the posttranslational modification of secreted gene products. Cellular and Molecular Life Sciences : Cmls. 62: 3067-79. PMID 16314929 DOI: 10.1007/S00018-005-5283-0  0.52
2005 Buczek O, Yoshikami D, Watkins M, Bulaj G, Jimenez EC, Olivera BM. Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily. The Febs Journal. 272: 4178-88. PMID 16098199 DOI: 10.1111/J.1742-4658.2005.04830.X  0.52
2005 Lubbers NL, Campbell TJ, Polakowski JS, Bulaj G, Layer RT, Moore J, Gross GJ, Cox BF. Postischemic administration of CGX-1051, a peptide from cone snail venom, reduces infarct size in both rat and dog models of myocardial ischemia and reperfusion. Journal of Cardiovascular Pharmacology. 46: 141-6. PMID 16044024 DOI: 10.1097/01.Fjc.0000167015.84715.27  0.52
2005 Bulaj G, West PJ, Garrett JE, Watkins M, Marsh M, Zhang MM, Norton RS, Smith BJ, Yoshikami D, Olivera BM. Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels. Biochemistry. 44: 7259-65. PMID 15882064 DOI: 10.1021/BI0473408  0.52
2005 Fuller E, Green BR, Catlin P, Buczek O, Nielsen JS, Olivera BM, Bulaj G. Oxidative folding of conotoxins sharing an identical disulfide bridging framework. The Febs Journal. 272: 1727-38. PMID 15794759 DOI: 10.1111/J.1742-4658.2005.04602.X  0.52
2005 Garrett JE, Buczek O, Watkins M, Olivera BM, Bulaj G. Biochemical and gene expression analyses of conotoxins in Conus textile venom ducts. Biochemical and Biophysical Research Communications. 328: 362-7. PMID 15670792 DOI: 10.1016/J.Bbrc.2004.12.178  0.52
2005 Buczek O, Yoshikami D, Bulaj G, Jimenez EC, Olivera BM. Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide. The Journal of Biological Chemistry. 280: 4247-53. PMID 15561705 DOI: 10.1074/Jbc.M405835200  0.52
2005 Buczek O, Yoshikami D, Watkins M, Bulaj G, Jiminez EC, Olivera BM. Erratum: Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily (FEBS Journal (2005) 272 (4178-4188)) Febs Journal. 272. DOI: 10.1111/J.1742-4658.2005.04916.X  0.36
2004 Teichert RW, Rivier J, Dykert J, Cervini L, Gulyas J, Bulaj G, Ellison M, Olivera BM. AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors. Toxicon : Official Journal of the International Society On Toxinology. 44: 207-14. PMID 15246771 DOI: 10.1016/J.Toxicon.2004.05.026  0.52
2004 Bulaj G, Koehn RE, Goldenberg DP. Alteration of the disulfide-coupled folding pathway of BPTI by circular permutation Protein Science. 13: 1182-1196. PMID 15096625 DOI: 10.1110/Ps.03563704  0.52
2004 Buczek O, Olivera BM, Bulaj G. Propeptide does not act as an intramolecular chaperone but facilitates protein disulfide isomerase-assisted folding of a conotoxin precursor. Biochemistry. 43: 1093-101. PMID 14744155 DOI: 10.1021/Bi0354233  0.52
2003 Bulaj G, Buczek O, Goodsell I, Jimenez EC, Kranski J, Nielsen JS, Garrett JE, Olivera BM. Efficient oxidative folding of conotoxins and the radiation of venomous cone snails. Proceedings of the National Academy of Sciences of the United States of America. 100: 14562-8. PMID 14573706 DOI: 10.1073/Pnas.2335845100  0.52
2003 Keizer DW, West PJ, Lee EF, Yoshikami D, Olivera BM, Bulaj G, Norton RS. Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA. The Journal of Biological Chemistry. 278: 46805-13. PMID 12970353 DOI: 10.1074/Jbc.M309222200  0.52
2003 Van Horn JD, Bulaj G, Goldenberg DP, Burrows CJ. The Cys-Xaa-His metal-binding motif: [N] versus [S] coordination and nickel-mediated formation of cysteinyl sulfinic acid. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 8: 601-10. PMID 12827456 DOI: 10.1007/S00775-003-0454-7  0.52
2002 West PJ, Bulaj G, Garrett JE, Olivera BM, Yoshikami D. Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons. Biochemistry. 41: 15388-93. PMID 12484778 DOI: 10.1021/Bi0265628  0.36
2002 Miles LA, Dy CY, Nielsen J, Barnham KJ, Hinds MG, Olivera BM, Bulaj G, Norton RS. Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif. The Journal of Biological Chemistry. 277: 43033-40. PMID 12193600 DOI: 10.1074/Jbc.M206690200  0.52
2002 Maillo M, Aguilar MB, Lopéz-Vera E, Craig AG, Bulaj G, Olivera BM, Heimer de la Cotera EP. Conorfamide, a Conus venom peptide belonging to the RFamide family of neuropeptides. Toxicon : Official Journal of the International Society On Toxinology. 40: 401-7. PMID 11738233 DOI: 10.1016/S0041-0101(01)00176-3  0.36
2001 Bulaj G, DeLaCruz R, Azimi-Zonooz A, West P, Watkins M, Yoshikami D, Olivera BM. Delta-conotoxin structure/function through a cladistic analysis. Biochemistry. 40: 13201-8. PMID 11683628 DOI: 10.1021/Bi010683A  0.36
2001 Jones RM, Cartier GE, McIntosh JM, Bulaj G, Farrar VE, Olivera BM. Composition and therapeutic utility of conotoxins from genus Conus. Patent status 1996 - 2000 Expert Opinion On Therapeutic Patents. 11: 603-623. DOI: 10.1517/13543776.11.4.603  0.52
2000 McIntosh JM, Corpuz GO, Layer RT, Garrett JE, Wagstaff JD, Bulaj G, Vyazovkina A, Yoshikami D, Cruz LJ, Olivera BM. Isolation and characterization of a novel conus peptide with apparent antinociceptive activity. The Journal of Biological Chemistry. 275: 32391-7. PMID 10900201 DOI: 10.1074/Jbc.M003619200  0.52
1998 Bulaj G, Kortemme T, Goldenberg DP. Ionization-reactivity relationships for cysteine thiols in polypeptides. Biochemistry. 37: 8965-72. PMID 9636038 DOI: 10.1021/Bi973101R  0.52
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