Anthony H. Futerman - Publications

Affiliations: 
BCH Biological Chemistry Weizmann Institute of Science, Rehovot, Israel 
Area:
Biochemistry, Cell Biology, Pathology

209 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kim YR, Lee EJ, Shin KO, Kim MH, Pewzner-Jung Y, Lee YM, Park JW, Futerman AH, Park WJ. Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases. Experimental & Molecular Medicine. 51: 129. PMID 31676768 DOI: 10.1038/s12276-019-0340-1  0.36
2019 Paget C, Deng S, Soulard D, Priestman DA, Speca S, von Gerichten J, Speak AO, Saroha A, Pewzner-Jung Y, Futerman AH, Mallevaey T, Faveeuw C, Gu X, Platt FM, Sandhoff R, et al. TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells. Plos Biology. 17: e3000169. PMID 30822302 DOI: 10.1371/journal.pbio.3000169  0.36
2017 Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I. Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29196503 DOI: 10.1096/fj.201700571R  0.36
2017 Saroha A, Pewzner-Jung Y, Ferreira NS, Sharma P, Jouan Y, Kelly SL, Feldmesser E, Merrill AH, Trottein F, Paget C, Lang KS, Futerman AH. Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis. Frontiers in Immunology. 8: 1386. PMID 29163475 DOI: 10.3389/fimmu.2017.01386  0.36
2017 Kim YR, Volpert G, Shin KO, Kim SY, Shin SH, Lee Y, Sung SH, Lee YM, Ahn JH, Pewzner-Jung Y, Park WJ, Futerman AH, Park JW. Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability. Journal of Cellular and Molecular Medicine. PMID 28699686 DOI: 10.1111/jcmm.13267  0.36
2017 Volpert G, Ben-Dor S, Tarcic O, Duan J, Saada A, Merrill AH, Pewzner-Jung Y, Futerman AH. Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis. Journal of Cell Science. PMID 28280117 DOI: 10.1242/jcs.199968  0.36
2016 Hubel E, Saroha A, Park WJ, Pewzner-Jung Y, Lavoie EG, Futerman AH, Bruck R, Fishman S, Dranoff JA, Shibolet O, Zvibel I. Sortilin Deficiency Reduces Ductular Reaction, Hepatocyte Apoptosis, and Liver Fibrosis in Cholestatic-Induced Liver Injury. The American Journal of Pathology. PMID 27842214 DOI: 10.1016/j.ajpath.2016.09.005  0.36
2016 Choi S, Kim JA, Li HY, Shin KO, Oh GT, Lee YM, Oh S, Pewzner-Jung Y, Futerman AH, Suh SH. KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress. Aging Cell. PMID 27363720 DOI: 10.1111/acel.12502  1
2016 Vardi A, Zigdon H, Meshcheriakova A, Klein AD, Yaacobi C, Eilam R, Kenwood BM, Rahim AA, Massaro G, Merrill AH, Vitner EB, Futerman AH. Delineating pathological pathways in a chemically-induced mouse model of Gaucher disease. The Journal of Pathology. PMID 27234572 DOI: 10.1002/path.4751  1
2016 Vitner EB, Farfel-Becker T, Ferreira NS, Leshkowitz D, Sharma P, Lang KS, Futerman AH. Induction of the type I interferon response in neurological forms of Gaucher disease. Journal of Neuroinflammation. 13: 104. PMID 27175482 DOI: 10.1186/s12974-016-0570-2  1
2016 MacRitchie N, Volpert G, Al Washih M, Watson DG, Futerman AH, Kennedy S, Pyne S, Pyne NJ. Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling. PMID 27063355 DOI: 10.1016/j.cellsig.2016.03.014  1
2016 Varela AR, Couto AS, Fedorov A, Futerman AH, Prieto M, Silva LC. Glucosylceramide Reorganizes Cholesterol-Containing Domains in a Fluid Phospholipid Membrane. Biophysical Journal. 110: 612-22. PMID 26840726 DOI: 10.1016/j.bpj.2015.12.019  1
2016 Cingolani F, Futerman AH, Casas J. Ceramide synthases in biomedical research. Chemistry and Physics of Lipids. 197: 25-32. PMID 26248326 DOI: 10.1016/j.chemphyslip.2015.07.026  1
2015 Choi S, Kim JA, Kim TH, Li HY, Shin KO, Lee YM, Oh S, Pewzner-Jung Y, Futerman AH, Suh SH. Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via KC a 1.1 upregulation. Aging Cell. PMID 26288989 DOI: 10.1111/acel.12388  1
2015 Ali M, Saroha A, Pewzner-Jung Y, Futerman AH. LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme. Febs Letters. 589: 2213-7. PMID 26183206 DOI: 10.1016/j.febslet.2015.06.045  1
2015 Park WJ, Brenner O, Kogot-Levin A, Saada A, Merrill AH, Pewzner-Jung Y, Futerman AH. Development of pheochromocytoma in ceramide synthase 2 null mice. Endocrine-Related Cancer. 22: 623-32. PMID 26113602 DOI: 10.1530/ERC-15-0058  0.36
2015 Futerman AH. Preface to the Special Issue on brain lipids. Biochimica Et Biophysica Acta. 1851: 997-8. PMID 25869182 DOI: 10.1016/j.bbalip.2015.04.003  1
2015 Zigdon H, Savidor A, Levin Y, Meshcheriakova A, Schiffmann R, Futerman AH. Identification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease. Plos One. 10: e0120194. PMID 25775479 DOI: 10.1371/journal.pone.0120194  1
2015 Vitner EB, Futerman AH, Platt N. Innate immune responses in the brain of sphingolipid lysosomal storage diseases. Biological Chemistry. 396: 659-67. PMID 25720063 DOI: 10.1515/hsz-2014-0301  1
2015 Barthelmes J, de Bazo AM, Pewzner-Jung Y, Schmitz K, Mayer CA, Foerch C, Eberle M, Tafferner N, Ferreirós N, Henke M, Geisslinger G, Futerman AH, Grösch S, Schiffmann S. Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils. Brain, Behavior, and Immunity. 46: 280-92. PMID 25697397 DOI: 10.1016/j.bbi.2015.02.010  1
2015 Tidhar R, Sims K, Rosenfeld-Gur E, Shaw W, Futerman AH. A rapid ceramide synthase activity using NBD-sphinganine and solid phase extraction. Journal of Lipid Research. 56: 193-9. PMID 25368106 DOI: 10.1194/jlr.D052001  1
2015 Rabinowich L, Fishman S, Hubel E, Thurm T, Park WJ, Pewzner-Jung Y, Saroha A, Erez N, Halpern Z, Futerman AH, Zvibel I. Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity. Journal of Hepatology. 62: 175-81. PMID 25173968 DOI: 10.1016/j.jhep.2014.08.030  1
2015 Park WJ, Brenner O, Kogot-Levin A, Saada A, Merrill AH, Pewzner-Jung Y, Futerman AH. Development of pheochromocytoma in ceramide synthase 2 null mice Endocrine-Related Cancer. 22: 623-632. DOI: 10.1530/ERC-15-0058  1
2015 Vitner EB, Vardi A, Cox TM, Futerman AH. Emerging therapeutic targets for Gaucher disease Expert Opinion On Therapeutic Targets. 19: 321-334. DOI: 10.1517/14728222.2014.981530  1
2014 Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Dogra S, Öhman MK, Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA. CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance. Cell Metabolism. 20: 919. PMID 29665397 DOI: 10.1016/j.cmet.2014.10.007  0.36
2014 Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Chaurasia B, Dogra S, Öhman MK, Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA. CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell Metabolism. 20: 687-95. PMID 25295789 DOI: 10.1016/j.cmet.2014.09.015  1
2014 Park WJ, Park JW, Merrill AH, Storch J, Pewzner-Jung Y, Futerman AH. Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length. Biochimica Et Biophysica Acta. 1841: 1754-66. PMID 25241943 DOI: 10.1016/j.bbalip.2014.09.009  1
2014 Reuven EM, Ali M, Rotem E, Schwarzter R, Gramatica A, Futerman AH, Shai Y. The HIV-1 envelope transmembrane domain binds TLR2 through a distinct dimerization motif and inhibits TLR2-mediated responses. Plos Pathogens. 10: e1004248. PMID 25121610 DOI: 10.1371/journal.ppat.1004248  1
2014 Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. Embo Molecular Medicine. 6: 1205-14. PMID 25085879 DOI: 10.15252/emmm.201404075  1
2014 Elbaz-Alon Y, Rosenfeld-Gur E, Shinder V, Futerman AH, Geiger T, Schuldiner M. A dynamic interface between vacuoles and mitochondria in yeast. Developmental Cell. 30: 95-102. PMID 25026036 DOI: 10.1016/j.devcel.2014.06.007  1
2014 Jensen SA, Calvert AE, Volpert G, Kouri FM, Hurley LA, Luciano JP, Wu Y, Chalastanis A, Futerman AH, Stegh AH. Bcl2L13 is a ceramide synthase inhibitor in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. 111: 5682-7. PMID 24706805 DOI: 10.1073/pnas.1316700111  1
2014 Varela AR, Gonçalves da Silva AM, Fedorov A, Futerman AH, Prieto M, Silva LC. Influence of intracellular membrane pH on sphingolipid organization and membrane biophysical properties. Langmuir : the Acs Journal of Surfaces and Colloids. 30: 4094-104. PMID 24654655 DOI: 10.1021/la5003397  1
2014 Zigdon H, Meshcheriakova A, Futerman AH. From sheep to mice to cells: tools for the study of the sphingolipidoses. Biochimica Et Biophysica Acta. 1841: 1189-99. PMID 24607565 DOI: 10.1016/j.bbalip.2014.02.008  1
2014 Vitner EB, Salomon R, Farfel-Becker T, Meshcheriakova A, Ali M, Klein AD, Platt FM, Cox TM, Futerman AH. RIPK3 as a potential therapeutic target for Gaucher's disease Nature Medicine. 20: 204-208. PMID 24441827 DOI: 10.1038/nm.3449  1
2014 Pinto SN, Laviad EL, Stiban J, Kelly SL, Merrill AH, Prieto M, Futerman AH, Silva LC. Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain. Journal of Lipid Research. 55: 53-61. PMID 24163422 DOI: 10.1194/jlr.M042002  1
2014 Farfel-Becker T, Vitner EB, Kelly SL, Bame JR, Duan J, Shinder V, Merrill AH, Dobrenis K, Futerman AH. Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration. Human Molecular Genetics. 23: 843-54. PMID 24064337 DOI: 10.1093/hmg/ddt468  1
2014 Park JW, Park WJ, Futerman AH. Ceramide synthases as potential targets for therapeutic intervention in human diseases. Biochimica Et Biophysica Acta. 1841: 671-81. PMID 24021978 DOI: 10.1016/j.bbalip.2013.08.019  1
2013 Cohen Y, Megyeri M, Chen OC, Condomitti G, Riezman I, Loizides-Mangold U, Abdul-Sada A, Rimon N, Riezman H, Platt FM, Futerman AH, Schuldiner M. The yeast p5 type ATPase, spf1, regulates manganese transport into the endoplasmic reticulum. Plos One. 8: e85519. PMID 24392018 DOI: 10.1371/journal.pone.0085519  1
2013 Klein AD, Futerman AH. Lysosomal storage disorders: old diseases, present and future challenges. Pediatric Endocrinology Reviews : Per. 11: 59-63. PMID 24380123  1
2013 Ali M, Fritsch J, Zigdon H, Pewzner-Jung Y, Schütze S, Futerman AH. Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization. Cell Death & Disease. 4: e929. PMID 24263103 DOI: 10.1038/cddis.2013.451  1
2013 Park WJ, Park JW, Erez-Roman R, Kogot-Levin A, Bame JR, Tirosh B, Saada A, Merrill AH, Pewzner-Jung Y, Futerman AH. Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization. The Journal of Biological Chemistry. 288: 30904-16. PMID 24019516 DOI: 10.1074/jbc.M112.448852  1
2013 Halasiddappa LM, Koefeler H, Futerman AH, Hermetter A. Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases. Plos One. 8: e70002. PMID 23936132 DOI: 10.1371/journal.pone.0070002  1
2013 Pinto SN, Fernandes F, Fedorov A, Futerman AH, Silva LC, Prieto M. A combined fluorescence spectroscopy, confocal and 2-photon microscopy approach to re-evaluate the properties of sphingolipid domains. Biochimica Et Biophysica Acta. 1828: 2099-110. PMID 23702462 DOI: 10.1016/j.bbamem.2013.05.011  1
2013 Petrache I, Kamocki K, Poirier C, Pewzner-Jung Y, Laviad EL, Schweitzer KS, Van Demark M, Justice MJ, Hubbard WC, Futerman AH. Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. Plos One. 8: e62968. PMID 23690971 DOI: 10.1371/journal.pone.0062968  1
2013 Tidhar R, Futerman AH. The complexity of sphingolipid biosynthesis in the endoplasmic reticulum. Biochimica Et Biophysica Acta. 1833: 2511-8. PMID 23611790 DOI: 10.1016/j.bbamcr.2013.04.010  1
2013 Vitner EB, Futerman AH. Neuronal forms of Gaucher disease. Handbook of Experimental Pharmacology. 405-19. PMID 23563668 DOI: 10.1007/978-3-7091-1511-4_20  1
2013 Russo SB, Tidhar R, Futerman AH, Cowart LA. Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties. The Journal of Biological Chemistry. 288: 13397-409. PMID 23530041 DOI: 10.1074/jbc.M112.428185  1
2013 Zigdon H, Kogot-Levin A, Park JW, Goldschmidt R, Kelly S, Merrill AH, Scherz A, Pewzner-Jung Y, Saada A, Futerman AH. Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain. The Journal of Biological Chemistry. 288: 4947-56. PMID 23283968 DOI: 10.1074/jbc.M112.402719  1
2013 Harrer H, Laviad EL, Humpf HU, Futerman AH. Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins. Molecular Nutrition & Food Research. 57: 516-22. PMID 23281112 DOI: 10.1002/mnfr.201200465  1
2013 Varela AR, Gonçalves da Silva AM, Fedorov A, Futerman AH, Prieto M, Silva LC. Effect of glucosylceramide on the biophysical properties of fluid membranes. Biochimica Et Biophysica Acta. 1828: 1122-30. PMID 23196345 DOI: 10.1016/j.bbamem.2012.11.018  1
2013 Park JW, Park WJ, Kuperman Y, Boura-Halfon S, Pewzner-Jung Y, Futerman AH. Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes. Hepatology (Baltimore, Md.). 57: 525-32. PMID 22911490 DOI: 10.1002/hep.26015  1
2013 Offman MN, Silman I, Sussman JL, Futerman AH. Crystal structure of the enzyme acid b-glucosidase Advances in Gaucher Disease: Basic and Clinical Perspectives. 125-138. DOI: 10.2217/EBO.12.215  1
2012 Nevet MJ, Vekslin S, Dizhoor AM, Olshevskaya EV, Tidhar R, Futerman AH, Ben-Yosef T. Ceramide kinase-like (CERKL) interacts with neuronal calcium sensor proteins in the retina in a cation-dependent manner. Investigative Ophthalmology & Visual Science. 53: 4565-74. PMID 22678504 DOI: 10.1167/iovs.12-9770  1
2012 Vitner EB, Farfel-Becker T, Eilam R, Biton I, Futerman AH. Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease. Brain : a Journal of Neurology. 135: 1724-35. PMID 22566609 DOI: 10.1093/brain/aws095  1
2012 Laviad EL, Kelly S, Merrill AH, Futerman AH. Modulation of ceramide synthase activity via dimerization. The Journal of Biological Chemistry. 287: 21025-33. PMID 22539345 DOI: 10.1074/jbc.M112.363580  1
2012 Silva LC, Ben David O, Pewzner-Jung Y, Laviad EL, Stiban J, Bandyopadhyay S, Merrill AH, Prieto M, Futerman AH. Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes. Journal of Lipid Research. 53: 430-6. PMID 22231783 DOI: 10.1194/jlr.M022715  1
2012 Singh A, Wang H, Silva LC, Na C, Prieto M, Futerman AH, Luberto C, Del Poeta M. Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans. Cellular Microbiology. 14: 500-16. PMID 22151739 DOI: 10.1111/j.1462-5822.2011.01735.x  1
2012 Tidhar R, Ben-Dor S, Wang E, Kelly S, Merrill AH, Futerman AH. Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain. The Journal of Biological Chemistry. 287: 3197-206. PMID 22144673 DOI: 10.1074/jbc.M111.280271  1
2011 Yurlova L, Kahya N, Aggarwal S, Kaiser HJ, Chiantia S, Bakhti M, Pewzner-Jung Y, Ben-David O, Futerman AH, Brügger B, Simons M. Self-segregation of myelin membrane lipids in model membranes. Biophysical Journal. 101: 2713-20. PMID 22261060 DOI: 10.1016/j.bpj.2011.10.026  1
2011 Farfel-Becker T, Vitner EB, Futerman AH. Animal models for Gaucher disease research. Disease Models & Mechanisms. 4: 746-52. PMID 21954067 DOI: 10.1242/dmm.008185  1
2011 Pinto SN, Silva LC, Futerman AH, Prieto M. Effect of ceramide structure on membrane biophysical properties: the role of acyl chain length and unsaturation. Biochimica Et Biophysica Acta. 1808: 2753-60. PMID 21835161 DOI: 10.1016/j.bbamem.2011.07.023  1
2011 Offman MN, Krol M, Rost B, Silman I, Sussman JL, Futerman AH. Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-beta-glucosidase mutant that causes Gaucher disease. Protein Engineering, Design & Selection : Peds. 24: 773-5. PMID 21724649 DOI: 10.1093/protein/gzr032  1
2011 Ben-David O, Pewzner-Jung Y, Brenner O, Laviad EL, Kogot-Levin A, Weissberg I, Biton IE, Pienik R, Wang E, Kelly S, Alroy J, Raas-Rothschild A, Friedman A, Brügger B, Merrill AH, ... Futerman AH, et al. Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels. The Journal of Biological Chemistry. 286: 30022-33. PMID 21705317 DOI: 10.1074/jbc.M111.261206  1
2011 Shachar T, Lo Bianco C, Recchia A, Wiessner C, Raas-Rothschild A, Futerman AH. Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 1593-604. PMID 21618611 DOI: 10.1002/mds.23774  1
2011 Brumshtein B, Aguilar-Moncayo M, Benito JM, García Fernandez JM, Silman I, Shaaltiel Y, Aviezer D, Sussman JL, Futerman AH, Ortiz Mellet C. Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues Organic and Biomolecular Chemistry. 9: 4160-4167. PMID 21483943 DOI: 10.1039/c1ob05200d  1
2011 Goldschmidt-Arzi M, Shimoni E, Sabanay H, Futerman AH, Addadi L. Intracellular localization of organized lipid domains of C16-ceramide/cholesterol. Journal of Structural Biology. 175: 21-30. PMID 21473916 DOI: 10.1016/j.jsb.2011.03.021  1
2011 Farfel-Becker T, Vitner EB, Pressey SN, Eilam R, Cooper JD, Futerman AH. Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease. Human Molecular Genetics. 20: 1375-86. PMID 21252206 DOI: 10.1093/hmg/ddr019  1
2010 Offman MN, Krol M, Silman I, Sussman JL, Futerman AH. Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S Journal of Biological Chemistry. 285: 42105-42114. PMID 20980259 DOI: 10.1074/jbc.M110.172098  1
2010 Stiban J, Tidhar R, Futerman AH. Ceramide synthases: roles in cell physiology and signaling. Advances in Experimental Medicine and Biology. 688: 60-71. PMID 20919646 DOI: 10.1007/978-1-4419-6741-1_4  1
2010 Vitner EB, Dekel H, Zigdon H, Shachar T, Farfel-Becker T, Eilam R, Karlsson S, Futerman AH. Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses. Human Molecular Genetics. 19: 3583-90. PMID 20616152 DOI: 10.1093/hmg/ddq273  1
2010 Futerman AH, Schuldiner M. Lipids: The plasma membrane code. Nature Chemical Biology. 6: 487-8. PMID 20559315 DOI: 10.1038/nchembio.397  1
2010 Ben-David O, Futerman AH. The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases. Neuromolecular Medicine. 12: 341-50. PMID 20502986 DOI: 10.1007/s12017-010-8114-x  1
2010 Vitner EB, Platt FM, Futerman AH. Common and uncommon pathogenic cascades in lysosomal storage diseases. The Journal of Biological Chemistry. 285: 20423-7. PMID 20430897 DOI: 10.1074/jbc.R110.134452  1
2010 Levy M, Futerman AH. Mammalian ceramide synthases. Iubmb Life. 62: 347-56. PMID 20222015 DOI: 10.1002/iub.319  1
2010 Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, Horn-Saban S, Amann-Zalcenstein D, Raanan C, Berkutzki T, Erez-Roman R, Ben-David O, Levy M, Holzman D, Park H, ... ... Futerman AH, et al. A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. The Journal of Biological Chemistry. 285: 10911-23. PMID 20110366 DOI: 10.1074/jbc.M109.077610  0.36
2010 Pewzner-Jung Y, Park H, Laviad EL, Silva LC, Lahiri S, Stiban J, Erez-Roman R, Brügger B, Sachsenheimer T, Wieland F, Prieto M, Merrill AH, Futerman AH. A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. The Journal of Biological Chemistry. 285: 10902-10. PMID 20110363 DOI: 10.1074/jbc.M109.077594  1
2010 Erez-Roman R, Pienik R, Futerman AH. Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression. Biochemical and Biophysical Research Communications. 391: 219-23. PMID 19912991 DOI: 10.1016/j.bbrc.2009.11.035  1
2010 Sridevi P, Alexander H, Laviad EL, Min J, Mesika A, Hannink M, Futerman AH, Alexander S. Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing. Experimental Cell Research. 316: 78-91. PMID 19800881 DOI: 10.1016/j.yexcr.2009.09.027  1
2010 Brumshtein B, Salinas P, Peterson B, Chan V, Silman I, Sussman JL, Savickas PJ, Robinson GS, Futerman AH. Characterization of gene-activated human acid-β-glucosidase: Crystal structure, glycan composition, and internalization into macrophages Glycobiology. 20: 24-32. PMID 19741058 DOI: 10.1093/glycob/cwp138  1
2010 Farfel-Becker T, Futerman AH. Cellular pathogenesis in sphingolipid storage disorders: The quest for new therapeutic approaches Clinical Lipidology. 5: 255-265. DOI: 10.2217/clp.10.13  1
2010 Futerman AH. Calcium homeostasis in lysosomal storage diseases International Journal of Clinical Pharmacology and Therapeutics. 48.  1
2009 Goldfinger M, Laviad EL, Hadar R, Shmuel M, Dagan A, Park H, Merrill AH, Ringel I, Futerman AH, Tirosh B. De novo ceramide synthesis is required for N-linked glycosylation in plasma cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 7038-47. PMID 19454701 DOI: 10.4049/jimmunol.0802990  1
2009 Brumshtein B, Aguilar-Moncayo M, García-Moreno IM, Mellet CO, Fernández JGM, Silman I, Shaaltiel Y, Aviezer D, Sussman JL, Futerman AH. 6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene) nojirimycin: Synthesis, biological evaluation, and crystal structure in complex with acid β-glucosidase Chembiochem. 10: 1480-1485. PMID 19437524 DOI: 10.1002/cbic.200900142  1
2009 Sridevi P, Alexander H, Laviad EL, Pewzner-Jung Y, Hannink M, Futerman AH, Alexander S. Ceramide synthase 1 is regulated by proteasomal mediated turnover. Biochimica Et Biophysica Acta. 1793: 1218-27. PMID 19393694 DOI: 10.1016/j.bbamcr.2009.04.006  1
2009 Silva LC, Futerman AH, Prieto M. Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations. Biophysical Journal. 96: 3210-22. PMID 19383465 DOI: 10.1016/j.bpj.2008.12.3923  1
2009 Kacher Y, Futerman AH. Impaired IL-10 transcription and release in animal models of Gaucher disease macrophages. Blood Cells, Molecules & Diseases. 43: 134-7. PMID 19380242 DOI: 10.1016/j.bcmd.2009.03.006  1
2009 Lahiri S, Park H, Laviad EL, Lu X, Bittman R, Futerman AH. Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. The Journal of Biological Chemistry. 284: 16090-8. PMID 19357080 DOI: 10.1074/jbc.M807438200  1
2009 Farfel-Becker T, Vitner E, Dekel H, Leshem N, Enquist IB, Karlsson S, Futerman AH. No evidence for activation of the unfolded protein response in neuronopathic models of Gaucher disease. Human Molecular Genetics. 18: 1482-8. PMID 19193629 DOI: 10.1093/hmg/ddp061  1
2008 Kacher Y, Brumshtein B, Boldin-Adamsky S, Toker L, Shainskaya A, Silman I, Sussman JL, Futerman AH. Acid β-glucosidase: Insights from structural analysis and relevance to Gaucher disease therapy Biological Chemistry. 389: 1361-1369. PMID 18783340 DOI: 10.1515/BC.2008.163  1
2008 Ginzburg L, Li SC, Li YT, Futerman AH. An exposed carboxyl group on sialic acid is essential for gangliosides to inhibit calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase: relevance to gangliosidoses. Journal of Neurochemistry. 104: 140-6. PMID 18173730 DOI: 10.1111/j.1471-4159.2007.04983.x  1
2008 Laviad EL, Albee L, Pankova-Kholmyansky I, Epstein S, Park H, Merrill AH, Futerman AH. Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. The Journal of Biological Chemistry. 283: 5677-84. PMID 18165233 DOI: 10.1074/jbc.M707386200  1
2008 Stiban J, Silva LC, Futerman AH. Ceramide-containing membranes: The interface between biophysics and biology Trends in Glycoscience and Glycotechnology. 20: 297-313. DOI: 10.4052/tigg.20.297  1
2008 Brumshtein B, Greenblatt HM, Futerman AH, Silman I, Sussman JL. Control of the rate of evaporation in protein crystallization by the 'microbatch under oil' method Journal of Applied Crystallography. 41: 969-971. DOI: 10.1107/S0021889808024667  1
2007 Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH. Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. Febs Letters. 581: 5289-94. PMID 17977534 DOI: 10.1016/j.febslet.2007.10.018  1
2007 Scheffer L, Futerman AH, Addadi L. Antibody labeling of cholesterol/ceramide ordered domains in cell membranes. Chembiochem : a European Journal of Chemical Biology. 8: 2286-94. PMID 17957818 DOI: 10.1002/cbic.200700482  1
2007 Futerman AH. Cell biology: taxi service for lipids. Nature. 449: 35-7. PMID 17805285 DOI: 10.1038/449035a  1
2007 Min J, Mesika A, Sivaguru M, Van Veldhoven PP, Alexander H, Futerman AH, Alexander S. (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. Molecular Cancer Research : McR. 5: 801-12. PMID 17699106 DOI: 10.1158/1541-7786.MCR-07-0100  1
2007 Brumshtein B, Greenblatt HM, Butters TD, Shaaltiel Y, Aviezer D, Silman I, Futerman AH, Sussman JL. Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid β-glucosidase: Insights into the mechanism of chemical chaperone action in Gaucher disease Journal of Biological Chemistry. 282: 29052-29058. PMID 17666401 DOI: 10.1074/jbc.M705005200  1
2007 Mesika A, Ben-Dor S, Laviad EL, Futerman AH. A new functional motif in Hox domain-containing ceramide synthases: identification of a novel region flanking the Hox and TLC domains essential for activity. The Journal of Biological Chemistry. 282: 27366-73. PMID 17609214 DOI: 10.1074/jbc.M703487200  1
2007 Lahiri S, Futerman AH. The metabolism and function of sphingolipids and glycosphingolipids Cellular and Molecular Life Sciences. 64: 2270-2284. PMID 17558466 DOI: 10.1007/s00018-007-7076-0  1
2007 Kacher Y, Golan A, Pewzner-Jung Y, Futerman AH. Changes in macrophage morphology in a Gaucher disease model are dependent on CTP:phosphocholine cytidylyltransferase alpha. Blood Cells, Molecules & Diseases. 39: 124-9. PMID 17482853 DOI: 10.1016/j.bcmd.2007.03.005  1
2007 Shaaltiel Y, Bartfeld D, Hashmueli S, Baum G, Brill-Almon E, Galili G, Dym O, Boldin-Adamsky SA, Silman I, Sussman JL, Futerman AH, Aviezer D. Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system Plant Biotechnology Journal. 5: 579-590. DOI: 10.1111/j.1467-7652.2007.00263.x  1
2006 Brumshtein B, Wormald MR, Silman I, Futerman AH, Sussman JL. Structural comparison of differently glycosylated forms of acid-β-glucosidase, the defective enzyme in Gaucher disease Acta Crystallographica Section D: Biological Crystallography. 62: 1458-1465. PMID 17139081 DOI: 10.1107/S0907444906038303  1
2006 Futerman AH. Intracellular trafficking of sphingolipids: relationship to biosynthesis. Biochimica Et Biophysica Acta. 1758: 1885-92. PMID 16996025 DOI: 10.1016/j.bbamem.2006.08.004  1
2006 Kacher Y, Futerman AH. Genetic diseases of sphingolipid metabolism: pathological mechanisms and therapeutic options. Febs Letters. 580: 5510-7. PMID 16970941 DOI: 10.1016/j.febslet.2006.08.041  1
2006 Pewzner-Jung Y, Ben-Dor S, Futerman AH. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis. The Journal of Biological Chemistry. 281: 25001-5. PMID 16793762 DOI: 10.1074/jbc.R600010200  1
2006 Hillaert U, Boldin-Adamsky S, Rozenski J, Busson R, Futerman AH, Van Calenbergh S. Synthesis and biological evaluation of novel PDMP analogues. Bioorganic & Medicinal Chemistry. 14: 5273-84. PMID 16621573 DOI: 10.1016/j.bmc.2006.03.048  1
2006 Arfi A, Zisling R, Richard E, Batista L, Poenaru L, Futerman AH, Caillaud C. Reversion of the biochemical defects in murine embryonic Sandhoff neurons using a bicistronic lentiviral vector encoding hexosaminidase alpha and beta. Journal of Neurochemistry. 96: 1572-9. PMID 16441513 DOI: 10.1111/j.1471-4159.2006.03665.x  1
2006 Kacher Y, Futerman AH. Neuronal cell death in glycosphingolipidoses Sphingolipid Biology. 285-293. DOI: 10.1007/4-431-34200-1_22  1
2005 Ginzburg L, Futerman AH. Defective calcium homeostasis in the cerebellum in a mouse model of Niemann-Pick A disease. Journal of Neurochemistry. 95: 1619-28. PMID 16277603 DOI: 10.1111/j.1471-4159.2005.03534.x  1
2005 Lahiri S, Futerman AH. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. The Journal of Biological Chemistry. 280: 33735-8. PMID 16100120 DOI: 10.1074/jbc.M506485200  1
2005 Futerman AH, Riezman H. The ins and outs of sphingolipid synthesis. Trends in Cell Biology. 15: 312-8. PMID 15953549 DOI: 10.1016/j.tcb.2005.04.006  1
2005 Premkumar L, Sawkar AR, Boldin-Adamsky S, Toker L, Silman I, Kelly JW, Futerman AH, Sussman JL. X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. The Journal of Biological Chemistry. 280: 23815-9. PMID 15817452 DOI: 10.1074/jbc.M502799200  1
2005 Jmoudiak M, Futerman AH. Gaucher disease: pathological mechanisms and modern management. British Journal of Haematology. 129: 178-88. PMID 15813845 DOI: 10.1111/j.1365-2141.2004.05351.x  1
2005 Cohen T, Auerbach W, Ravid L, Bodennec J, Fein A, Futerman AH, Joyner AL, Horowitz M. The exon 8-containing prosaposin gene splice variant is dispensable for mouse development, lysosomal function, and secretion. Molecular and Cellular Biology. 25: 2431-40. PMID 15743835 DOI: 10.1128/MCB.25.6.2431-2440.2005  1
2005 Pelled D, Trajkovic-Bodennec S, Lloyd-Evans E, Sidransky E, Schiffmann R, Futerman AH. Enhanced calcium release in the acute neuronopathic form of Gaucher disease. Neurobiology of Disease. 18: 83-8. PMID 15649698 DOI: 10.1016/j.nbd.2004.09.004  1
2005 Futerman AH. Lysosomol storage diseases: Pathological mechanisms and therapeutic options Medecine/Sciences. 21: 16-19.  1
2004 Buccoliero R, Ginzburg L, Futerman AH. Elevation of lung surfactant phosphatidylcholine in mouse models of Sandhoff and of Niemann-Pick A disease Journal of Inherited Metabolic Disease. 27: 641-648. PMID 15669680 DOI: 10.1023/B:BOLI.0000042958.22066.6c  1
2004 Ganor Y, Goldberg-Stern H, Amrom D, Lerman-Sagie T, Teichberg VI, Pelled D, Futerman AH, Zeev BB, Freilinger M, Verheulpen D, Van Bogaert P, Levite M. Autoimmune epilepsy: some epilepsy patients harbor autoantibodies to glutamate receptors and dsDNA on both sides of the blood-brain barrier, which may kill neurons and decrease in brain fluids after hemispherotomy. Clinical & Developmental Immunology. 11: 241-52. PMID 15559370 DOI: 10.1080/17402520400001736  1
2004 Raas-Rothschild A, Pankova-Kholmyansky I, Kacher Y, Futerman AH. Glycosphingolipidoses: beyond the enzymatic defect. Glycoconjugate Journal. 21: 295-304. PMID 15514478 DOI: 10.1023/B:GLYC.0000046272.38480.ef  1
2004 Futerman AH, Hannun YA. The complex life of simple sphingolipids. Embo Reports. 5: 777-82. PMID 15289826 DOI: 10.1038/sj.embor.7400208  1
2004 Futerman AH, Van Meer G. The cell biology of lysosomal storage disorders Nature Reviews Molecular Cell Biology. 5: 554-565. PMID 15232573 DOI: 10.1038/nrm1423  1
2004 Trajkovic-Bodennec S, Bodennec J, Futerman AH. Phosphatidylcholine metabolism is altered in a monocyte-derived macrophage model of Gaucher disease but not in lymphocytes Blood Cells, Molecules, and Diseases. 33: 77-82. PMID 15223015 DOI: 10.1016/j.bcmd.2004.03.001  1
2004 Ginzburg L, Kacher Y, Futerman AH. The pathogenesis of glycosphingolipid storage disorders. Seminars in Cell & Developmental Biology. 15: 417-31. PMID 15207832 DOI: 10.1016/j.semcdb.2004.03.003  1
2004 Buccoliero R, Bodennec J, Van Echten-Deckert G, Sandhoff K, Futerman AH. Phospholipid synthesis is decreased in neuronal tissue in a mouse model of Sandhoff disease Journal of Neurochemistry. 90: 80-88. PMID 15198669 DOI: 10.1111/j.1471-4159.2004.02457.x  1
2004 Futerman AH, Sussman JL, Horowitz M, Silman I, Zimran A. New directions in the treatment of Gaucher disease. Trends in Pharmacological Sciences. 25: 147-51. PMID 15019270 DOI: 10.1016/j.tips.2004.01.004  1
2003 Lloyd-Evans E, Pelled D, Riebeling C, Futerman AH. Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms Biochemical Journal. 375: 561-565. PMID 12917012 DOI: 10.1042/BJ20030613  1
2003 Riebeling C, Allegood JC, Wang E, Merrill AH, Futerman AH. Two Mammalian Longevity Assurance Gene (LAG1) Family Members, trh1 and trh4, Regulate Dihydroceramide Synthesis Using Different Fatty Acyl-CoA Donors Journal of Biological Chemistry. 278: 43452-43459. PMID 12912983 DOI: 10.1074/jbc.M307104200  1
2003 Pelled D, Riebeling C, Van Echten-Deckert G, Sandhoff K, Futerman AH. Reduced rates of axonal and dendritic growth in embryonic hippocampal neurones cultured from a mouse model of Sandhoff disease Neuropathology and Applied Neurobiology. 29: 341-349. PMID 12887594 DOI: 10.1046/j.1365-2990.2003.00455.x  1
2003 Dvir H, Harel M, McCarthy AA, Toker L, Silman I, Futerman AH, Sussman JL. X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease. Embo Reports. 4: 704-9. PMID 12792654 DOI: 10.1038/sj.embor.embor873  1
2003 Pelled D, Lloyd-Evans E, Riebeling C, Jeyakumar M, Platt FM, Futerman AH. Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin Journal of Biological Chemistry. 278: 29496-29501. PMID 12756243 DOI: 10.1074/jbc.M302964200  1
2003 Bodennec J, Trajkovic-Bodennec S, Futerman AH. Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [3H]acetic anhydride Journal of Lipid Research. 44: 1413-1419. PMID 12730305 DOI: 10.1194/jlr.D300010-JLR200  1
2003 Lloyd-Evans E, Pelled D, Riebeling C, Bodennec J, de-Morgan A, Waller H, Schiffmann R, Futerman AH. Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. The Journal of Biological Chemistry. 278: 23594-9. PMID 12709427 DOI: 10.1074/jbc.M300212200  1
2003 Buccoliero R, Futerman AH. The roles of ceramide and complex sphingolipids in neuronal cell function Pharmacological Research. 47: 409-419. PMID 12676515 DOI: 10.1016/S1043-6618(03)00049-5  1
2003 Bodennec J, Pelled D, Futerman AH. Aminopropyl solid phase extraction and 2 D TLC of neutral glycosphingolipids and neutral lysoglycosphingolipids Journal of Lipid Research. 44: 218-226. PMID 12518041 DOI: 10.1194/jlr.D200026-JLR200  1
2002 Watanabe R, Funato K, Venkataraman K, Futerman AH, Riezman H. Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. The Journal of Biological Chemistry. 277: 49538-44. PMID 12393888 DOI: 10.1074/jbc.M206209200  1
2002 Buccoliero R, Bodennec J, Futerman AH. The role of sphingolipids in neuronal development: Lessons from models of sphingolipid storage diseases Neurochemical Research. 27: 565-574. PMID 12374191 DOI: 10.1023/A:1020207613196  1
2002 Venkataraman K, Futerman AH. Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis? Febs Letters. 528: 3-4. PMID 12297269 DOI: 10.1016/S0014-5793(02)03248-9  1
2002 Bodennec J, Pelled D, Riebeling C, Trajkovic S, Futerman AH. Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP:phosphocholine cytidylyltransferase by glucosylceramide The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1814-1816. PMID 12223447  1
2002 Venkataraman K, Riebeling C, Bodennec J, Riezman H, Allegood JC, Sullards MC, Merrill AH, Futerman AH. Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. The Journal of Biological Chemistry. 277: 35642-9. PMID 12105227 DOI: 10.1074/jbc.M205211200  1
2002 Brann AB, Tcherpakov M, Williams IM, Futerman AH, Fainzilber M. Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase. The Journal of Biological Chemistry. 277: 9812-8. PMID 11777929 DOI: 10.1074/jbc.M109862200  1
2002 Pelled D, Raveh T, Riebeling C, Fridkin M, Berissi H, Futerman AH, Kimchi A. Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. The Journal of Biological Chemistry. 277: 1957-61. PMID 11709549 DOI: 10.1074/jbc.M104677200  1
2001 Shogomori H, Futerman AH. Cholesterol depletion by methyl-β-cyclodextrin blocks cholera toxin transport from endosomes to the Golgi apparatus in hippocampal neurons Journal of Neurochemistry. 78: 991-999. PMID 11553673 DOI: 10.1046/j.1471-4159.2001.00489.x  1
2001 Venkataraman K, Futerman AH. Comparison of the metabolism of L-erythro- and L-threo-sphinganines and ceramides in cultured cells and in subcellular fractions. Biochimica Et Biophysica Acta. 1530: 219-26. PMID 11239824 DOI: 10.1016/S1388-1981(01)00085-3  1
2001 Shogomori H, Futerman AH. Cholera Toxin is Found in Detergent-insoluble Rafts/Domains at the Cell Surface of Hippocampal Neurons but is Internalized via a Raft-independent Mechanism Journal of Biological Chemistry. 276: 9182-9188. PMID 11113142 DOI: 10.1074/jbc.M009414200  1
2000 Terstappen GC, Futerman AH, Schwarz A. Cloud-point extraction of gangliosides using non-ionic detergent C14EO6 Methods in Enzymology. 312: 187-196. PMID 11070872  1
2000 Schwarz A, Futerman AH. Immunolocalization of gangliosides by light microscopy using anti-ganglioside antibodies Methods in Enzymology. 312: 179-187. PMID 11070871  1
2000 Van Overmeire I, Boldin SA, Venkataraman K, Zisling R, De Jonghe S, Van Calenbergh S, De Keukeleire D, Futerman AH, Herdewijn P. Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety. Journal of Medicinal Chemistry. 43: 4189-99. PMID 11063615 DOI: 10.1021/jm000939v  1
2000 Venkataraman K, Futerman AH. Ceramide as a second messenger: sticky solutions to sticky problems. Trends in Cell Biology. 10: 408-12. PMID 10998592 DOI: 10.1016/S0962-8924(00)01830-4  1
2000 Pelled D, Shogomori H, Futerman AH. The increased sensitivity of neurons with elevated glucocerebroside to neurotoxic agents can be reversed by imiglucerase Journal of Inherited Metabolic Disease. 23: 175-184. PMID 10801059 DOI: 10.1023/A:1005622001239  1
2000 Boldin SA, Futerman AH. Up-regulation of glucosylceramide synthesis upon stimulation of axonal growth by basic fibroblast growth factor. Evidence for post-translational modification of glucosylceramide synthase Journal of Biological Chemistry. 275: 9905-9909. PMID 10744663 DOI: 10.1074/jbc.275.14.9905  1
2000 Neuberger Y, Shogomori H, Levy Z, Fainzilber M, Futerman AH. A lyso-platelet activating factor phospholipase C, originally suggested to be a neutral-sphingomyelinase, is located in the endoplasmic reticulum. Febs Letters. 469: 44-6. PMID 10708753 DOI: 10.1016/S0014-5793(00)01235-7  1
2000 Schwarz A, Jürgens L, Licht A, Schneider H, Futerman AH, Pecht I. An IgE-dependent secretory response of mast cells can be induced by a glycosphingolipid-specific monoclonal antibody. European Journal of Immunology. 30: 217-26. PMID 10602044 DOI: 10.1002/1521-4141(200001)30:1<217::AID-IMMU217>3.0.CO;2-0  1
1999 Futerman AH, Boldin SA, Brann AB, Pelled D, Meivar-Levy I, Zisling R. Regulation of sphingolipid and glycosphingolipid metabolism during neuronal growth and development Biochemical Society Transactions. 27: 432-437. PMID 10917616  1
1999 Brann AB, Scott R, Neuberger Y, Abulafia D, Boldin S, Fainzilber M, Futerman AH. Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 8199-206. PMID 10493721  1
1999 Shogomori H, Burack MA, Banker G, Futerman AH. Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons. Febs Letters. 458: 107-11. PMID 10481046 DOI: 10.1016/S0014-5793(99)01146-1  1
1999 Levite M, Fleidervish IA, Schwarz A, Pelled D, Futerman AH. Autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel Journal of Autoimmunity. 13: 61-72. PMID 10441169 DOI: 10.1006/jaut.1999.0301  1
1999 Korkotian E, Schwarz A, Pelled D, Schwarzmann G, Segal M, Futerman AH. Elevation of intracellular glucosylceramide levels results in an increase in endoplasmic reticulum density and in functional calcium stores in cultured neurons Journal of Biological Chemistry. 274: 21673-21678. PMID 10419477 DOI: 10.1074/jbc.274.31.21673  1
1999 Van Overmeire I, Boldin SA, Dumont F, Van Calenbergh S, Slegers G, De Keukeleire D, Futerman AH, Herdewijn P. Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons Journal of Medicinal Chemistry. 42: 2697-2705. PMID 10411490 DOI: 10.1021/jm990091e  1
1999 Naslavsky N, Shmeeda H, Friedlander G, Yanai A, Futerman AH, Barenholz Y, Taraboulos A. Sphingolipid depletion increases formation of the scrapie prion protein in neuroblastoma cells infected with prions Journal of Biological Chemistry. 274: 20763-20771. PMID 10409615 DOI: 10.1074/jbc.274.30.20763  1
1999 Meivar-Levy I, Futerman AH. Up-regulation of neutral glycosphingolipid synthesis upon long term inhibition of ceramide synthesis by fumonisin B1 Journal of Biological Chemistry. 274: 4607-4612. PMID 9988695 DOI: 10.1074/jbc.274.8.4607  1
1998 Futerman AH, Ghidoni R, Van Meer G. A kibbutz full of lipids. Lipids: Regulatory Functions in Membrane Traffic and Cell Development, Kfar Blum Kibbutz Guest House, Galilee, Israel, May 10-15, 1998 Embo Journal. 17: 6772-6775. PMID 9835653  1
1998 Futerman AH. Distinct roles for sphingolipids and glycosphingolipids at different stages of neuronal development Acta Biochimica Polonica. 45: 469-478. PMID 9821876  1
1998 Khanin R, Segel L, Futerman AH. The diffusion of molecules in axonal plasma membranes: The sites of insertion of new membrane molecules and their distribution along the axon surface Journal of Theoretical Biology. 193: 371-382. PMID 9735267 DOI: 10.1006/jtbi.1998.0707  1
1998 Schwarz A, Futerman AH. Inhibition of sphingolipid synthesis, but not degradation, alters the rate of dendrite growth in cultured hippocampal neurons Developmental Brain Research. 108: 125-130. PMID 9693790 DOI: 10.1016/S0165-3806(98)00041-8  1
1998 Futerman AH, Boldin S, Brann AB, Schwarz A, Zisling R. Regulatory roles for sphingolipids in the growth of polarized neurons Annals of the New York Academy of Sciences. 845: 176-187. PMID 9668351 DOI: 10.1111/j.1749-6632.1998.tb09670.x  1
1998 Futerman AH. The roles of ceramide in the regulation of neuronal growth and development Biochemistry (Moscow). 63: 74-83. PMID 9526098  1
1998 Van Echten-Deckert G, Giannis A, Schwarz A, Futerman AH, Sandhoff K. 1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis Journal of Biological Chemistry. 273: 1184-1191. PMID 9422785 DOI: 10.1074/jbc.273.2.1184  1
1997 Schwarz A, Terstappen GC, Futerman AH. Isolation of gangliosides by cloud-point extraction with a nonionic detergent Analytical Biochemistry. 254: 221-225. PMID 9417780 DOI: 10.1006/abio.1997.2419  1
1997 Safran N, Haring R, Shainberg A, Zisling R, Futerman AH, Shahar A. Nerve cell death induced by Ca2+ ionophores in dissociated hippocampal cultures: Protective action of the NMDA antagonist MK-801 Advances in Experimental Medicine and Biology. 429: 207-219. PMID 9413576  1
1997 Samuel N, Wonnacott S, Lindstrom J, Futerman AH. Parallel increases in [α-125I]bungarotoxin binding and α7 nicotinic subunit immunoreactivity during the development of rat hippocampal neurons in culture Neuroscience Letters. 222: 179-182. PMID 9148244 DOI: 10.1016/S0304-3940(97)13377-8  1
1997 Schwarz A, Futerman AH. Determination of the localization of gangliosides using anti- ganglioside antibodies: Comparison of fixation methods Journal of Histochemistry and Cytochemistry. 45: 611-618. PMID 9111239  1
1997 Schwarz A, Futerman AH. Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth Journal of Neuroscience. 17: 2929-2938. PMID 9096129  1
1997 Boldin S, Futerman AH. Glucosylceramide synthesis is required for basic fibroblast growth factor and laminin to stimulate axonal growth Journal of Neurochemistry. 68: 882-885. PMID 9003082  1
1997 Meivar-Levy I, Sabanay H, Bershadsky AD, Futerman AH. The role of sphingolipids in the maintenance of fibroblast morphology. The inhibition of protrusional activity, cell spreading, and cytokinesis induced by fumonisin B1 can be reversed by ganglioside GM3. The Journal of Biological Chemistry. 272: 1558-64. PMID 8999828 DOI: 10.1074/jbc.272.3.1558  1
1996 Schwarz A, Futerman AH. The localization of gangliosides in neurons of the central nervous system: The use of anti-ganglioside antibodies Biochimica Et Biophysica Acta - Reviews On Biomembranes. 1286: 247-267. PMID 8982285 DOI: 10.1016/S0304-4157(96)00011-1  1
1996 Sofer A, Futerman AH. Rate of retrograde transport of cholera toxin from the plasma membrane to the Golgi apparatus and endoplasmic reticulum decreases during neuronal development Journal of Neurochemistry. 67: 2134-2140. PMID 8863523  1
1996 Sofer A, Schwarzmann G, Futerman AH. The internalization of a short acyl chain analogue of ganglioside GM1 in polarized neurons Journal of Cell Science. 109: 2111-2119. PMID 8856507  1
1996 Harel R, Futerman AH. A newly-synthesized GPI-anchored protein, TAG-1/axonin-1, is inserted into axonal membranes along the entire length of the axon and not exclusively at the growth cone Brain Research. 712: 345-348. PMID 8814912 DOI: 10.1016/0006-8993(95)01516-7  1
1996 Hirschberg K, Zisling R, Van Echten-Deckert G, Futerman AH. Ganglioside synthesis during the development of neuronal polarity: Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis Journal of Biological Chemistry. 271: 14876-14882. PMID 8663007 DOI: 10.1074/jbc.271.25.14876  1
1996 Futerman AH, Banker GA. The economics of neurite outgrowth--the addition of new membrane to growing axons. Trends in Neurosciences. 19: 144-9. PMID 8658598 DOI: 10.1016/S0166-2236(96)80025-7  1
1995 Futerman AH, Hirschberg K, Meivar-Levy I, Rapaport E, Schwarz A, Sofer A, Zisling R. Vesicle transport during cell growth and in the maintenance of cell polarity Biochemical Society Transactions. 23: 530-534. PMID 8566408  1
1995 Sofer A, Futerman AH. Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP Journal of Biological Chemistry. 270: 12117-12122. PMID 7744860 DOI: 10.1074/jbc.270.20.12117  1
1995 Schwarz A, Rapaport E, Hirschberg K, Futerman AH. A regulatory role for sphingolipids in neuronal growth: Inhibition of sphingolipid synthesis and degradation have opposite effects on axonal branching Journal of Biological Chemistry. 270: 10990-10998. PMID 7738041  1
1995 Koval M, Futerman AH, Pagano RE. Sphingomyelin synthesis in endosomal compartments? Trends in Cell Biology. 5: 148-149. DOI: 10.1016/S0962-8924(00)88969-2  1
1995 Futerman AH. Inhibition of sphingolipid synthesis: Effects on glycosphingolipid-GPI-anchored protein microdomains Trends in Cell Biology. 5: 377-380.  1
1994 Bershadsky AD, Futerman AH. Disruption of the Golgi apparatus by brefeldin A blocks cell polarization and inhibits directed cell migration. Proceedings of the National Academy of Sciences of the United States of America. 91: 5686-9. PMID 8202549 DOI: 10.1073/pnas.91.12.5686  1
1994 Meivar-Levy I, Horowitz M, Futerman AH. Analysis of glucocerebrosidase activity using N-(1-[14C]hexanoyl)-D-erythro-glucosylsphingosine demonstrates a correlation between levels of residual enzyme activity and the type of Gaucher disease Biochemical Journal. 303: 377-382. PMID 7980395  1
1993 Hirschberg K, Rodger J, Futerman AH. The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver Biochemical Journal. 290: 751-757. PMID 8457204  1
1993 Futerman AH, Khanin R, Segel LA. Lipid diffusion in neurons [4] Nature. 362: 119. PMID 8450884  1
1993 Boudker O, Futerman AH. Detection and characterization of ceramide-1-phosphate phosphatase activity in rat liver plasma membrane Journal of Biological Chemistry. 268: 22150-22155. PMID 8408075  1
1993 Harel R, Futerman AH. Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons Journal of Biological Chemistry. 268: 14476-14481. PMID 8314804  1
1992 Futerman AH, Pagano RE. Use of N-([1-14C]Hexanoyl)-D-erythro-sphingolipids to assay sphingolipid metabolism Methods in Enzymology. 209: 437-446. PMID 1495424 DOI: 10.1016/0076-6879(92)09054-7  1
1991 Futerman AH, Pagano RE. Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver Biochemical Journal. 280: 295-302. PMID 1747103  1
1990 Futerman AH, Stieger B, Hubbard AL, Pagano RE. Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus. The Journal of Biological Chemistry. 265: 8650-7. PMID 2187869  1
1988 Inestrosa NC, Fuentes ME, Anglister L, Futerman AH, Silman I. A membrane-associated dimer of acetylcholinesterase from Xenopus skeletal muscle is solubilized by phosphatidylinositol-specific phospholipase C. Neuroscience Letters. 90: 186-90. PMID 3412641 DOI: 10.1016/0304-3940(88)90809-9  1
1988 SILMAN I, FUTERMAN AH. Modes of attachment of acetylcholinesterase to the surface membrane European Journal of Biochemistry. 170: 11-22. PMID 3319614  1
1988 Sussman JL, Harel M, Frolow F, Varon L, Toker L, Futerman AH, Silman I. Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C. Journal of Molecular Biology. 203: 821-3. PMID 2850366 DOI: 10.1016/0022-2836(88)90213-6  1
1987 Low MG, Futerman AH, Ackermann KE, Sherman WR, Silman I. Removal of covalently bound inositol from Torpedo acetylcholinesterase and mammalian alkaline phosphatases by deamination with nitrous acid. Evidence for a common membrane-anchoring structure Biochemical Journal. 241: 615-619. PMID 3593210  1
1987 Silman I, Futerman AH. Posttranslational modification as a means of anchoring acetylcholinesterase to the cell surface Biopolymers - Peptide Science Section. 26. PMID 3555636  1
1987 Futerman AH, Raviv D, Michaelson DM, Silman I. Differential susceptibility to phosphatidylinositol-specific phospholipase C of acetylcholinesterase in excitable tissues of embryonic and adult Torpedo ocellata Brain Research. 388: 105-112. PMID 3040164 DOI: 10.1016/0169-328X(87)90003-9  1
1986 Low MG, Ferguson MAJ, Futerman AH, Silman I. Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins Trends in Biochemical Sciences. 11: 212-215. DOI: 10.1016/0968-0004(86)90009-5  1
1985 Futerman AH, Low MG, Michaelson DM, Silman I. Solubilization of Membrane‐Bound Acetyicholinesterase by a Phosphatidylinositol‐Specific Phospholipase C Journal of Neurochemistry. 45: 1487-1494. PMID 4045459 DOI: 10.1111/j.1471-4159.1985.tb07217.x  1
1985 Futerman AH, Low MG, Ackermann KE, Sherman WR, Silman I. Identification of covalently bound inositol in the hydrophobic membrane-anchoring domain of Torpedo acetylcholinesterase Biochemical and Biophysical Research Communications. 129: 312-317. PMID 4004881 DOI: 10.1016/0006-291X(85)91439-1  1
1985 Barton PL, Futerman AH, Silman I. Arrhenius plots of acetylcholinesterase activity in mammalian erythrocytes and in Torpedo electric organ. Effect of solubilization by proteinases and by a phosphatidylinositol-specific phospholipase C Biochemical Journal. 231: 237-240. PMID 3904734  1
1985 Futerman AH, Fiorini RM, Roth E, Low MG, Silman I. Physicochemical behaviour and structural characteristics of membrane-bound acetylcholinesterase from Torpedo electric organ. Effect of phosphatidylinositol-specific phospholipase C Biochemical Journal. 226: 369-377. PMID 2986594  1
1983 Futerman AH, Low MG, Silman I. A hydrophobic dimer of acetylcholinesterase from Torpedo californica electric organ is solubilized by phosphatidylinositol-specific phospholipase C Neuroscience Letters. 40: 85-89. PMID 6633970 DOI: 10.1016/0304-3940(83)90097-6  1
1982 Shakespeare PG, Stokes SH, Futerman AH. Heat Inactivation of Gamma-Glutamyltransferase in Homogenates of Human Kidney Annals of Clinical Biochemistry. 19: 43-46. PMID 6121531 DOI: 10.1177/000456328201900109  1
1981 Futerman AH, Harrison R, Lunt GG, Wonnacott S. Inhibition by anti-(nicotinic acetylcholine receptor) antibodies of acetylcholine-induced dopamine release from striatal nerve terminals Biochemical Society Transactions. 9: 410-411.  1
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