Randy Y. C. Poon - Publications

Affiliations: 
Hong Kong University of Science and Technology (Hong Kong) 
Area:
Biochemistry

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lok TM, Wang Y, Xu WK, Xie S, Ma HT, Poon RYC. Mitotic slippage is determined by p31 and the weakening of the spindle-assembly checkpoint. Oncogene. PMID 32029899 DOI: 10.1038/s41388-020-1187-6  1
2019 Mak JPY, Ma HT, Poon RYC. Synergism between ATM and PARP1 inhibition involves DNA damage and abrogating the G2 DNA damage checkpoint. Molecular Cancer Therapeutics. PMID 31597711 DOI: 10.1158/1535-7163.MCT-19-0474  1
2019 Zeng X, Xu WK, Lok TM, Ma HT, Poon RYC. Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics. Cell Death & Disease. 10: 314. PMID 30952840 DOI: 10.1038/s41419-019-1539-8  1
2018 Ng LY, Ma HT, Liu JCY, Huang X, Lee N, Poon RYC. Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation. Cell Cycle (Georgetown, Tex.). PMID 30582405 DOI: 10.1080/15384101.2018.1563395  1
2018 Ma HT, Poon RYC. TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2. Cell Reports. 22: 1439-1450. PMID 29425500 DOI: 10.1016/j.celrep.2018.01.027  1
2017 Xia W, Lo CM, Poon RYC, Cheung TT, Chan ACY, Chen L, Yang S, Tsao GSW, Wang XQ. Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells. Oncotarget. PMID 28415588 DOI: 10.18632/oncotarget.16402  1
2017 Ma HT, Poon RY. Synchronization of HeLa Cells. Methods in Molecular Biology (Clifton, N.J.). 1524: 189-201. PMID 27815904 DOI: 10.1007/978-1-4939-6603-5_12  1
2016 Huang S, Tang R, Poon RY. BCL-W is a regulator of microtubule inhibitor-induced mitotic cell death. Oncotarget. PMID 27231850 DOI: 10.18632/oncotarget.9586  1
2016 Wong PY, Ma HT, Lee HJ, Poon RY. MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation. Scientific Reports. 6: 22230. PMID 26923777 DOI: 10.1038/srep22230  1
2016 Ma HT, Poon RY. TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint. Cell Reports. PMID 26832417 DOI: 10.1016/j.celrep.2016.01.001  1
2015 Wong WK, Kelly T, Li J, Ma HT, Poon RY. SGO1C is a non-functional isoform of Shugoshin and can disrupts sister chromatid cohesion by interacting with PP2A-B56. Cell Cycle (Georgetown, Tex.). 0. PMID 26506018 DOI: 10.1080/15384101.2015.1104439  1
2015 Xie S, Mortusewicz O, Ma HT, Herr P, Poon RR, Helleday T, Qian C. Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair. Molecular Cell. 60: 163-76. PMID 26344098 DOI: 10.1016/j.molcel.2015.07.031  1
2015 Mak JP, Man WY, Chow JP, Ma HT, Poon RY. Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells. Oncotarget. PMID 26025928  1
2015 Li J, Hong MJ, Chow JP, Man WY, Mak JP, Ma HT, Poon RY. Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe. Oncotarget. 6: 9327-40. PMID 25871386  1
2014 Mak JP, Man WY, Ma HT, Poon RY. Pharmacological targeting the ATR-CHK1-WEE1 axis involves balancing cell growth stimulation and apoptosis. Oncotarget. 5: 10546-57. PMID 25301733 DOI: 10.18632/oncotarget.2508  1
2014 Ma HT, Erdal S, Huang S, Poon RY. Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance. Molecular Oncology. 8: 1404-18. PMID 24950801 DOI: 10.1016/j.molonc.2014.05.007  1
2014 Xing X, Poon RY, Wong CS, Yobas L. Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes. Biosensors & Bioelectronics. 61: 434-42. PMID 24934744 DOI: 10.1016/j.bios.2014.05.054  1
2014 Wang XQ, Chan KK, Ming X, Lui VC, Poon RY, Lo CM, Norbury C, Poon RT. G1 checkpoint establishment in vivo during embryonic liver development. Bmc Developmental Biology. 14: 23. PMID 24886500 DOI: 10.1186/1471-213X-14-23  1
2014 Chen H, Huang S, Han X, Zhang J, Shan C, Tsang YH, Ma HT, Poon RY. Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death. Cell Death & Disease. 5: e1177. PMID 24743732 DOI: 10.1038/cddis.2014.154  1
2014 Man WY, Mak JP, Poon RY. Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint. Journal of Cellular and Molecular Medicine. 18: 143-55. PMID 24238094 DOI: 10.1111/jcmm.12176  1
2014 Marxer M, Ma HT, Man WY, Poon RY. p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases. Oncogene. 33: 3550-60. PMID 23955083 DOI: 10.1038/onc.2013.325  1
2013 Chow JP, Man WY, Mao M, Chen H, Cheung F, Nicholls J, Tsao SW, Li Lung M, Poon RY. PARP1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy. Molecular Cancer Therapeutics. 12: 2517-28. PMID 23979918 DOI: 10.1158/1535-7163.MCT-13-0010  1
2013 Han X, Poon RY. Critical differences between isoforms of securin reveal mechanisms of separase regulation. Molecular and Cellular Biology. 33: 3400-15. PMID 23798554 DOI: 10.1128/MCB.00057-13  1
2012 Tsang YH, Han X, Man WY, Lee N, Poon RY. Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints. Plos One. 7: e49943. PMID 23189174 DOI: 10.1371/journal.pone.0049943  1
2012 Marxer M, Foucar CE, Man WY, Chen Y, Ma HT, Poon RY. Tetraploidization increases sensitivity to Aurora B kinase inhibition. Cell Cycle (Georgetown, Tex.). 11: 2567-77. PMID 22722494 DOI: 10.4161/cc.20947  1
2012 Ma HT, Chan YY, Chen X, On KF, Poon RY. Depletion of p31comet protein promotes sensitivity to antimitotic drugs. The Journal of Biological Chemistry. 287: 21561-9. PMID 22544748 DOI: 10.1074/jbc.M112.364356  1
2012 Chen Y, Chow JP, Poon RY. Inhibition of Eg5 acts synergistically with checkpoint abrogation in promoting mitotic catastrophe. Molecular Cancer Research : McR. 10: 626-35. PMID 22522457 DOI: 10.1158/1541-7786.MCR-11-0491  1
2011 Uchida S, Watanabe N, Kudo Y, Yoshioka K, Matsunaga T, Ishizaka Y, Nakagama H, Poon RY, Yamashita K. SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation. Journal of Cell Science. 124: 2816-25. PMID 21807946 DOI: 10.1242/jcs.083931  1
2011 Ma HT, Poon RY. Synchronization of HeLa cells. Methods in Molecular Biology (Clifton, N.J.). 761: 151-61. PMID 21755447 DOI: 10.1007/978-1-61779-182-6_10  1
2011 On KF, Chen Y, Ma HT, Chow JP, Poon RY. Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01. Molecular Cancer Therapeutics. 10: 784-94. PMID 21430130 DOI: 10.1158/1535-7163.MCT-10-0809  1
2011 Ma HT, Poon RY. How protein kinases co-ordinate mitosis in animal cells. The Biochemical Journal. 435: 17-31. PMID 21406064 DOI: 10.1042/BJ20100284  1
2011 Ma HT, Poon RY. Orderly inactivation of the key checkpoint protein mitotic arrest deficient 2 (MAD2) during mitotic progression. The Journal of Biological Chemistry. 286: 13052-9. PMID 21335556 DOI: 10.1074/jbc.M110.201897  1
2011 Chow JP, Poon RY, Ma HT. Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit. Molecular and Cellular Biology. 31: 1478-91. PMID 21262764 DOI: 10.1128/MCB.00891-10  1
2010 Ho CC, Hau PM, Marxer M, Poon RY. The requirement of p53 for maintaining chromosomal stability during tetraploidization. Oncotarget. 1: 583-95. PMID 21317454 DOI: 10.18632/oncotarget.101107  1
2010 Ma HT, Poon RY. Gene down-regulation with short hairpin RNAs and validation of specificity by inducible rescue in mammalian cells. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 27.2. PMID 21154550 DOI: 10.1002/0471143030.cb2702s49  1
2010 Poon RY. Polyploidization and cancer. Preface. Advances in Experimental Medicine and Biology. 676: vii. PMID 20687465  1
2010 Ma HT, Poon RY. Genome reduplication: redeployment of cyclin-CDK complexes and spontaneous oscillation of APC/C. Cell Cycle (Georgetown, Tex.). 9: 431-2. PMID 20090418  1
2009 Ma HT, Tsang YH, Marxer M, Poon RY. Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis. Molecular and Cellular Biology. 29: 6500-14. PMID 19822658 DOI: 10.1128/MCB.00669-09  1
2009 Uchida S, Yoshioka K, Kizu R, Nakagama H, Matsunaga T, Ishizaka Y, Poon RY, Yamashita K. Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation. Cancer Research. 69: 6438-44. PMID 19638579 DOI: 10.1158/0008-5472.CAN-09-0869  1
2008 Chen Y, Poon RY. The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability. Frontiers in Bioscience : a Journal and Virtual Library. 13: 5016-29. PMID 18508566  1
2008 Chan YW, Ma HT, Wong W, Ho CC, On KF, Poon RY. CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis. Cell Cycle (Georgetown, Tex.). 7: 1449-61. PMID 18418077  1
2008 Chan YW, On KF, Chan WM, Wong W, Siu HO, Hau PM, Poon RY. The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint. The Journal of Biological Chemistry. 283: 15716-23. PMID 18400748 DOI: 10.1074/jbc.M800629200  1
2007 Poon RY. Mitotic phosphorylation: breaking the balance of power by a tactical retreat. The Biochemical Journal. 403: e5-7. PMID 17376029 DOI: 10.1042/BJ20070290  1
2007 Fung TK, Ma HT, Poon RY. Specialized roles of the two mitotic cyclins in somatic cells: cyclin A as an activator of M phase-promoting factor. Molecular Biology of the Cell. 18: 1861-73. PMID 17344473 DOI: 10.1091/mbc.E06-12-1092  1
2007 Chan WM, Poon RY. The p53 Isoform Deltap53 lacks intrinsic transcriptional activity and reveals the critical role of nuclear import in dominant-negative activity. Cancer Research. 67: 1959-69. PMID 17332323 DOI: 10.1158/0008-5472.CAN-06-3602  1
2007 Ma HT, On KF, Tsang YH, Poon RY. An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells. Nucleic Acids Research. 35: e22. PMID 17234679 DOI: 10.1093/nar/gkl1109  1
2006 Hau PM, Siu WY, Wong N, Lai PB, Poon RY. Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells. Febs Letters. 580: 4727-36. PMID 16887121 DOI: 10.1016/j.febslet.2006.07.059  1
2006 Ho CC, Siu WY, Lau A, Chan WM, Arooz T, Poon RY. Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways. Cancer Research. 66: 2233-41. PMID 16489026 DOI: 10.1158/0008-5472.CAN-05-1790  1
2006 Chan WM, Mak MC, Fung TK, Lau A, Siu WY, Poon RY. Ubiquitination of p53 at multiple sites in the DNA-binding domain. Molecular Cancer Research : McR. 4: 15-25. PMID 16446403 DOI: 10.1158/1541-7786.MCR-05-0097  1
2005 Fung TK, Yam CH, Poon RY. The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites. Cell Cycle (Georgetown, Tex.). 4: 1411-20. PMID 16123593  1
2005 Fung TK, Poon RY. A roller coaster ride with the mitotic cyclins. Seminars in Cell & Developmental Biology. 16: 335-42. PMID 15840442 DOI: 10.1016/j.semcdb.2005.02.014  1
2005 Ho CC, Siu WY, Chow JP, Lau A, Arooz T, Tong HY, Ng IO, Poon RY. The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint. Experimental Cell Research. 304: 1-15. PMID 15707569 DOI: 10.1016/j.yexcr.2004.10.016  1
2004 Woo RA, Poon RY. Gene mutations and aneuploidy: the instability that causes cancer. Cell Cycle (Georgetown, Tex.). 3: 1101-3. PMID 15326384  1
2004 Cheung N, So CW, Yam JW, So CK, Poon RY, Jin DY, Chan LC. Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia. The Biochemical Journal. 383: 27-35. PMID 15214844 DOI: 10.1042/BJ20040041  1
2004 Woo RA, Poon RY. Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation. Genes & Development. 18: 1317-30. PMID 15175263 DOI: 10.1101/gad.1165204  1
2004 Siu WY, Lau A, Arooz T, Chow JP, Ho HT, Poon RY. Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms. Molecular Cancer Therapeutics. 3: 621-32. PMID 15141020  1
2004 Chan WM, Siu WY, Lau A, Poon RY. How many mutant p53 molecules are needed to inactivate a tetramer? Molecular and Cellular Biology. 24: 3536-51. PMID 15060172  1
2004 Ng CP, Lee HC, Ho CW, Arooz T, Siu WY, Lau A, Poon RY. Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. The Journal of Biological Chemistry. 279: 8808-19. PMID 14681223 DOI: 10.1074/jbc.M312215200  1
2003 Tsang FC, Po LS, Leung KM, Lau A, Siu WY, Poon RY. ING1b decreases cell proliferation through p53-dependent and -independent mechanisms. Febs Letters. 553: 277-85. PMID 14572637  1
2003 Chow JP, Siu WY, Fung TK, Chan WM, Lau A, Arooz T, Ng CP, Yamashita K, Poon RY. DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase. Molecular Biology of the Cell. 14: 3989-4002. PMID 14517313 DOI: 10.1091/mbc.E03-03-0168  1
2003 Chow JP, Siu WY, Ho HT, Ma KH, Ho CC, Poon RY. Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints. The Journal of Biological Chemistry. 278: 40815-28. PMID 12912980 DOI: 10.1074/jbc.M306683200  1
2003 Woo RA, Poon RY. Cyclin-dependent kinases and S phase control in mammalian cells. Cell Cycle (Georgetown, Tex.). 2: 316-24. PMID 12851482  1
2002 Yam CH, Fung TK, Poon RY. Cyclin A in cell cycle control and cancer. Cellular and Molecular Life Sciences : Cmls. 59: 1317-26. PMID 12363035 DOI: 10.1007/s00018-002-8510-y  1
2002 Leung KM, Po LS, Tsang FC, Siu WY, Lau A, Ho HT, Poon RY. The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2. Cancer Research. 62: 4890-3. PMID 12208736  1
2002 Fung TK, Siu WY, Yam CH, Lau A, Poon RY. Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins. The Journal of Biological Chemistry. 277: 35140-9. PMID 12122006 DOI: 10.1074/jbc.M205503200  1
2002 Li KK, Ng IO, Fan ST, Albrecht JH, Yamashita K, Poon RY. Activation of cyclin-dependent kinases CDC2 and CDK2 in hepatocellular carcinoma. Liver. 22: 259-68. PMID 12100577  1
2001 Yam CH, Siu WY, Kaganovich D, Ruderman JV, Poon RY. Cleavage of cyclin A at R70/R71 by the bacterial protease OmpT. Proceedings of the National Academy of Sciences of the United States of America. 98: 497-501. PMID 11136238 DOI: 10.1073/pnas.240461397  1
2000 Arooz T, Yam CH, Siu WY, Lau A, Li KK, Poon RY. On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells. Biochemistry. 39: 9494-501. PMID 10924145 DOI: 10.1021/bi0009643  1
2000 Yam CH, Siu WY, Lau A, Poon RY. Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2. The Journal of Biological Chemistry. 275: 3158-67. PMID 10652300 DOI: 10.1074/jbc.275.5.3158  1
2000 Yeung PK, New DC, Leveson A, Yam CH, Poon RY, Wong JT. The spindle checkpoint in the dinoflagellate Crypthecodinium cohnii. Experimental Cell Research. 254: 120-9. PMID 10623472 DOI: 10.1006/excr.1999.4749  1
1999 Siu WY, Yam CH, Poon RY. G1 versus G2 cell cycle arrest after adriamycin-induced damage in mouse Swiss3T3 cells. Febs Letters. 461: 299-305. PMID 10567715 DOI: 10.1016/S0014-5793(99)01481-7  1
1999 Yam CH, Siu WY, Arooz T, Chiu CH, Lau A, Wang XQ, Poon RY. MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins. Cancer Research. 59: 5075-8. PMID 10537276  1
1999 Yam CH, Ng RW, Siu WY, Lau AW, Poon RY. Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2. Molecular and Cellular Biology. 19: 635-45. PMID 9858587  1
1998 Ng RW, Arooz T, Yam CH, Chan IW, Lau AW, Poon RY. Characterization of the cullin and F-box protein partner Skp1. Febs Letters. 438: 183-9. PMID 9827542 DOI: 10.1016/S0014-5793(98)01299-X  1
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