Gregory P. Tochtrop - Publications

Chemistry Case Western Reserve University, Cleveland Heights, OH, United States 

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, ... ... Tochtrop GP, et al. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nature Communications. 9: 1976. PMID 29773803 DOI: 10.1038/s41467-018-04261-1  0.48
2017 Barker EC, Kim BG, Yoon JH, Tochtrop GP, Letterio JJ, Choi SH. Potent Suppression of Both Spontaneous and Carcinogen-induced Colitis-associated Colorectal Cancer in Mice by Dietary Celastrol Supplementation. Carcinogenesis. PMID 29069290 DOI: 10.1093/carcin/bgx115  0.36
2017 Wilson KA, Han Y, Zhang M, Hess J, Chapman KA, Cline GW, Tochtrop GP, Brunengraber H, Zhang GF. Interrelations between 3-hydroxypropionate and propionate metabolism in rat liver: Relevance to disorders of propionyl-CoA metabolism. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00105.2017. PMID 28634175 DOI: 10.1152/ajpendo.00105.2017  0.6
2015 Horváth G, Bencsura Á, Simon Á, Tochtrop GP, DeKoster GT, Covey DF, Cistola DP, Toke O. Structural determinants of ligand binding in the ternary complex of human ileal bile acid-binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR. The Febs Journal. PMID 26613247 DOI: 10.1111/febs.13610  1
2015 Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Molecular pharmacodynamics of emixustat in protection against retinal degeneration. The Journal of Clinical Investigation. 125: 2781-94. PMID 26075817 DOI: 10.1172/JCI80950  1
2015 Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nature Chemical Biology. 11: 409-15. PMID 25894083 DOI: 10.1038/nchembio.1799  1
2014 Jin Z, Berthiaume JM, Li Q, Henry F, Huang Z, Sadhukhan S, Gao P, Tochtrop GP, Puchowicz MA, Zhang GF. Catabolism of (2E)-4-hydroxy-2-nonenal via ω- and ω-1-oxidation stimulated by ketogenic diet. The Journal of Biological Chemistry. 289: 32327-38. PMID 25274632 DOI: 10.1074/jbc.M114.602458  1
2014 Gatbonton-Schwager TN, Sadhukhan S, Zhang GF, Letterio JJ, Tochtrop GP. Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal. Redox Biology. 2: 755-63. PMID 25009777 DOI: 10.1016/j.redox.2014.04.009  1
2014 Sadhukhan S, Zhang GF, Tochtrop GP. Modular isotopomer synthesis of γ-hydroxybutyric acid for a quantitative analysis of metabolic fates. Acs Chemical Biology. 9: 1706-11. PMID 24933109 DOI: 10.1021/cb500380b  1
2014 Sadhukhan S, Han Y, Jin Z, Tochtrop GP, Zhang GF. Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver. Free Radical Biology & Medicine. 70: 78-85. PMID 24556413 DOI: 10.1016/j.freeradbiomed.2014.02.008  1
2014 Li Q, Tochtrop GP. New methodology toward α,β-unsaturated carboxylic acids from saturated acids. Organic Letters. 16: 1382-5. PMID 24552572 DOI: 10.1021/ol500127u  1
2013 Ignatenko VA, Han Y, Tochtrop GP. Direct access to 6/5/7/5- and 6/7/5/5-fused tetracyclic triterpenoids via divergent transannular aldol reaction of lanosterol-derived diketone. The Journal of Organic Chemistry. 78: 12229-35. PMID 24161022 DOI: 10.1021/jo402005b  1
2013 Levi L, Lobo G, Doud MK, von Lintig J, Seachrist D, Tochtrop GP, Noy N. Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis. Cancer Research. 73: 4770-80. PMID 23722546 DOI: 10.1158/0008-5472.CAN-13-0384  1
2013 Ignatenko VA, Tochtrop GP. Approach for expanding triterpenoid complexity via divergent Norrish-Yang photocyclization. The Journal of Organic Chemistry. 78: 3821-31. PMID 23544445 DOI: 10.1021/jo400275p  1
2013 Li Q, Sadhukhan S, Berthiaume JM, Ibarra RA, Tang H, Deng S, Hamilton E, Nagy LE, Tochtrop GP, Zhang GF. 4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart. Free Radical Biology & Medicine. 58: 35-44. PMID 23328733 DOI: 10.1016/j.freeradbiomed.2013.01.005  1
2013 Ignatenko VA, Han Y, Tochtrop GP. Molecular library synthesis using complex substrates: expanding the framework of triterpenoids. The Journal of Organic Chemistry. 78: 410-8. PMID 23245400 DOI: 10.1021/jo302211f  1
2013 Harris SR, Zhang GF, Sadhukhan S, Wang H, Shi C, Puchowicz MA, Anderson VE, Salomon RG, Tochtrop GP, Brunengraber H. Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate. Chemical Research in Toxicology. 26: 213-20. PMID 23171137 DOI: 10.1021/tx3003643  1
2012 Petty A, Myshkin E, Qin H, Guo H, Miao H, Tochtrop GP, Hsieh JT, Page P, Liu L, Lindner DJ, Acharya C, MacKerell AD, Ficker E, Song J, Wang B. A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo. Plos One. 7: e42120. PMID 22916121 DOI: 10.1371/journal.pone.0042120  1
2012 Zhang GF, Sadhukhan S, Ibarra RA, Lauden SM, Chuang CY, Sushailo S, Chatterjee P, Anderson VE, Tochtrop GP, Brunengraber H. Metabolism of γ-hydroxybutyrate in perfused rat livers. The Biochemical Journal. 444: 333-41. PMID 22428548 DOI: 10.1042/BJ20112046  1
2012 Gatbonton-Schwager TN, Letterio JJ, Tochtrop GP. Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo. Journal of Natural Products. 75: 591-8. PMID 22339499 DOI: 10.1021/np200823p  1
2012 Tochtrop GP, Looper RE. Targeted chemical libraries Chemical Genomics. 60-73. DOI: 10.1017/CBO9781139021500.008  1
2011 Zhang GF, Sadhukhan S, Tochtrop GP, Brunengraber H. Metabolomics, pathway regulation, and pathway discovery. The Journal of Biological Chemistry. 286: 23631-5. PMID 21566142 DOI: 10.1074/jbc.R110.171405  1
2011 Tang X, Sayre LM, Tochtrop GP. A mass spectrometric analysis of 4-hydroxy-2-(E)-nonenal modification of cytochrome c. Journal of Mass Spectrometry : Jms. 46: 290-7. PMID 21394845 DOI: 10.1002/jms.1890  1
2011 Tomcik K, Ibarra RA, Sadhukhan S, Han Y, Tochtrop GP, Zhang GF. Isotopomer enrichment assay for very short chain fatty acids and its metabolic applications. Analytical Biochemistry. 410: 110-7. PMID 21112315 DOI: 10.1016/j.ab.2010.11.030  1
2011 Li Q, Tochtrop GP. A stereoselective synthesis of the allo-bile acids from the 5β-isomers Tetrahedron Letters. 52: 4137-4139. DOI: 10.1016/j.tetlet.2011.05.140  1
2010 Chakrabarti E, Ghosh S, Sadhukhan S, Sayre L, Tochtrop GP, Smith JD. Synthesis and biological evaluation of analogues of a novel inhibitor of beta-amyloid secretion. Journal of Medicinal Chemistry. 53: 5302-19. PMID 20568779 DOI: 10.1021/jm100308g  1
2010 Barker EC, Gatbonton-Schwager TN, Han Y, Clay JE, Letterio JJ, Tochtrop GP. Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages. Journal of Natural Products. 73: 1064-8. PMID 20481554 DOI: 10.1021/np1000076  1
2010 Sadhukhan S, Han Y, Zhang GF, Brunengraber H, Tochtrop GP. Using isotopic tools to dissect and quantitate parallel metabolic pathways. Journal of the American Chemical Society. 132: 6309-11. PMID 20408520 DOI: 10.1021/ja100399m  1
2010 Zhu X, Tang X, Zhang J, Tochtrop GP, Anderson VE, Sayre LM. Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal. Chemical Research in Toxicology. 23: 467-73. PMID 20070074 DOI: 10.1021/tx900379a  1
2009 Ghosh S, Tochtrop GP. A new strategy for the synthesis of β-benzylmercaptoethylamine derivatives. Tetrahedron Letters. 50: 1723-1726. PMID 23741077 DOI: 10.1016/j.tetlet.2009.01.133  1
2009 Zhang GF, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre LM, Ray D, Gibson KM, Anderson VA, Tochtrop GP, Brunengraber H. Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs. The Journal of Biological Chemistry. 284: 33521-34. PMID 19759021 DOI: 10.1074/jbc.M109.055665  1
2009 Tochtrop GP, Sadhukhan S, Koner RR, Ghosh S. The syntheses and applications of β-benzylmercaptoethylamine derivatives Tetrahedron. 65: 10515-10534. DOI: 10.1016/j.tet.2009.10.041  1
2008 Han Y, Alexander TE, Tochtrop GP. Design, synthesis, and evaluation of an isotopic labeling strategy for studying fatty acid-protein binding by NMR. Molecular Biosystems. 4: 551-7. PMID 18493652 DOI: 10.1039/b800471d  1
2006 Toke O, Monsey JD, DeKoster GT, Tochtrop GP, Tang C, Cistola DP. Determinants of cooperativity and site selectivity in human ileal bile acid binding protein. Biochemistry. 45: 727-37. PMID 16411748 DOI: 10.1021/bi051781p  1
2005 Cegelski L, Rice CV, O'Connor RD, Caruano AL, Tochtrop GP, Cai ZY, Covey DF, Schaefer J. Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR Drug Development Research. 66: 93-102. DOI: 10.1002/ddr.20048  1
2004 Tochtrop GP, King RW. Target identification strategies in chemical genetics. Combinatorial Chemistry & High Throughput Screening. 7: 677-88. PMID 15578930  1
2004 Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, King RW. Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science (New York, N.Y.). 306: 117-20. PMID 15459393 DOI: 10.1126/science.1100946  1
2004 Tochtrop GP, DeKoster GT, Covey DF, Cistola DP. A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein. Journal of the American Chemical Society. 126: 11024-9. PMID 15339188 DOI: 10.1021/ja047589c  1
2003 Tochtrop GP, Bruns JL, Tang C, Covey DF, Cistola DP. Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein. Biochemistry. 42: 11561-7. PMID 14529265 DOI: 10.1021/bi0346502  1
2002 Tochtrop GP, DeKoster GT, Cistola DP, Covey DF. Synthesis of [3,4-(13)c(2)]-enriched bile salts as NMR probes of protein-ligand interactions. The Journal of Organic Chemistry. 67: 6764-71. PMID 12227809 DOI: 10.1021/jo0259109  1
2002 Tochtrop GP, Richter K, Tang C, Toner JJ, Covey DF, Cistola DP. Energetics by NMR: site-specific binding in a positively cooperative system. Proceedings of the National Academy of Sciences of the United States of America. 99: 1847-52. PMID 11854486 DOI: 10.1073/pnas.012379199  1
2002 Tochtrop GP, DeKoster GT, Cistola DP, Covey DF. A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions. Bioorganic & Medicinal Chemistry Letters. 12: 433-5. PMID 11814814 DOI: 10.1016/S0960-894X(01)00763-6  1
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