Bruce E. Clurman - Publications

Molecular and Cellular Biology University of Washington, Seattle, Seattle, WA 
Molecular Biology, Biochemistry

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Diab A, Gem H, Swanger J, Kim HY, Smith K, Zou G, Raju S, Kao M, Fitzgibbon M, Loeb KR, Rodriguez CP, Méndez E, Galloway DA, Sidorova JM, Clurman BE. FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition. Proceedings of the National Academy of Sciences of the United States of America. PMID 33093209 DOI: 10.1073/pnas.2013921117  0.44
2020 Chi Y, Carter JH, Swanger J, Mazin AV, Moritz RL, Clurman BE. A novel landscape of nuclear human CDK2 substrates revealed by in situ phosphorylation. Science Advances. 6: eaaz9899. PMID 32494624 DOI: 10.1126/sciadv.aaz9899  0.44
2019 Loeb KR, Hughes BT, Fissel BM, Osteen NJ, Knoblaugh SE, Grim JE, Drury LJ, Sarver A, Dupuy AJ, Clurman BE. Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice. Scientific Reports. 9: 5488. PMID 30940846 DOI: 10.1038/s41598-019-41805-x  0.44
2018 Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE. Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735700 DOI: 10.1073/pnas.1718338115  0.44
2017 Davis RJ, Swanger J, Hughes BT, Clurman BE. The PP2A-B56 phosphatase opposes cyclin E autocatalytic degradation via site-specific dephosphorylation. Molecular and Cellular Biology. PMID 28137908 DOI: 10.1128/MCB.00657-16  0.44
2015 Toledo CM, Ding Y, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, ... ... Clurman BE, et al. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells. Cell Reports. PMID 26673326 DOI: 10.1016/j.celrep.2015.11.021  0.44
2015 Park E, Lee B, Clurman B, Lee K. NUP50 is necessary for the survival of primordial germ cells in mouse embryos. Reproduction (Cambridge, England). PMID 26515778 DOI: 10.1530/REP-14-0649  0.44
2014 Zhao H, Faltermeier CM, Mendelsohn L, Porter PL, Clurman BE, Roberts JM. Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy. Oncotarget. 5: 12704-14. PMID 25587029  0.44
2014 Welcker M, Clurman BE. Oncoprotein ubiquitylation: dimers, degrons, and degradation. Cell Cycle (Georgetown, Tex.). 13: 1829-30. PMID 24866825 DOI: 10.4161/cc.29325  0.44
2013 Welcker M, Larimore EA, Swanger J, Bengoechea-Alonso MT, Grim JE, Ericsson J, Zheng N, Clurman BE. Fbw7 dimerization determines the specificity and robustness of substrate degradation. Genes & Development. 27: 2531-6. PMID 24298052 DOI: 10.1101/gad.229195.113  0.44
2013 Sancho R, Blake SM, Tendeng C, Clurman BE, Lewis J, Behrens A. Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. Plos Biology. 11: e1001586. PMID 23776410 DOI: 10.1371/journal.pbio.1001586  0.44
2013 Hughes BT, Sidorova J, Swanger J, Monnat RJ, Clurman BE. Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation. Proceedings of the National Academy of Sciences of the United States of America. 110: 8954-9. PMID 23671119 DOI: 10.1073/pnas.1302927110  0.44
2013 Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell. 153: 707-20. PMID 23622250 DOI: 10.1016/j.cell.2013.03.030  0.44
2013 Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RL, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S, Shan SO, Deshaies RJ. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell. 153: 206-15. PMID 23453757 DOI: 10.1016/j.cell.2013.02.024  0.44
2013 Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Genes & Development. 27: 151-6. PMID 23322298 DOI: 10.1101/gad.207720.112  0.44
2013 Hizli AA, Chi Y, Swanger J, Carter JH, Liao Y, Welcker M, Ryazanov AG, Clurman BE. Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. Molecular and Cellular Biology. 33: 596-604. PMID 23184662 DOI: 10.1128/MCB.01270-12  0.44
2012 Grim JE, Knoblaugh SE, Guthrie KA, Hagar A, Swanger J, Hespelt J, Delrow JJ, Small T, Grady WM, Nakayama KI, Clurman BE. Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. Molecular and Cellular Biology. 32: 2160-7. PMID 22473991 DOI: 10.1128/MCB.00305-12  0.44
2011 Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC. Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Molecular and Cellular Biology. 31: 3885-95. PMID 21746877 DOI: 10.1128/MCB.05089-11  0.44
2011 Kuppers DA, Hwang HC, Jackson AL, Linsley PS, Clurman BE, Fero ML. Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma. Plos One. 6: e14758. PMID 21412408 DOI: 10.1371/journal.pone.0014758  0.44
2011 Welcker M, Larimore EA, Frappier L, Clurman BE. Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3. Molecular and Cellular Biology. 31: 1214-24. PMID 21220517 DOI: 10.1128/MCB.01347-10  0.44
2008 Chi Y, Welcker M, Hizli AA, Posakony JJ, Aebersold R, Clurman BE. Identification of CDK2 substrates in human cell lysates. Genome Biology. 9: R149. PMID 18847512 DOI: 10.1186/gb-2008-9-10-r149  0.44
2008 Liu H, Huang J, Wang J, Jiang S, Bailey AS, Goldman DC, Welcker M, Bedell V, Slovak ML, Clurman B, Thayer M, Fleming WH, Epner E. Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma. The Journal of Experimental Medicine. 205: 1843-58. PMID 18625744 DOI: 10.1084/jem.20072102  0.44
2008 Grim JE, Gustafson MP, Hirata RK, Hagar AC, Swanger J, Welcker M, Hwang HC, Ericsson J, Russell DW, Clurman BE. Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. The Journal of Cell Biology. 181: 913-20. PMID 18559665 DOI: 10.1083/jcb.200802076  0.44
2008 Minella AC, Loeb KR, Knecht A, Welcker M, Varnum-Finney BJ, Bernstein ID, Roberts JM, Clurman BE. Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes & Development. 22: 1677-89. PMID 18559482 DOI: 10.1101/gad.1650208  0.44
2008 Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nature Reviews. Cancer. 8: 83-93. PMID 18094723 DOI: 10.1038/nrc2290  0.44
2007 Garrett-Engele CM, Tasch MA, Hwang HC, Fero ML, Perlmutter RM, Clurman BE, Roberts JM. A mechanism misregulating p27 in tumors discovered in a functional genomic screen. Plos Genetics. 3: e219. PMID 18069898 DOI: 10.1371/journal.pgen.0030219  0.44
2007 O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, Hardwick J, Welcker M, Meijerink JP, Pieters R, Draetta G, Sears R, Clurman BE, Look AT. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. The Journal of Experimental Medicine. 204: 1813-24. PMID 17646409 DOI: 10.1084/jem.20070876  0.44
2007 Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA, Roberts JM. Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes & Development. 21: 1731-46. PMID 17626791 DOI: 10.1101/gad.1556607  0.44
2007 Chen X, Barton LF, Chi Y, Clurman BE, Roberts JM. Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome. Molecular Cell. 26: 843-52. PMID 17588519 DOI: 10.1016/j.molcel.2007.05.022  0.44
2007 Minella AC, Grim JE, Welcker M, Clurman BE. p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability Oncogene. 26: 6948-6953. PMID 17486057 DOI: 10.1038/sj.onc.1210518  0.44
2007 Welcker M, Clurman BE. Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Division. 2: 7. PMID 17298674 DOI: 10.1186/1747-1028-2-7  0.44
2007 Geng Y, Lee YM, Welcker M, Swanger J, Zagozdzon A, Winer JD, Roberts JM, Kaldis P, Clurman BE, Sicinski P. Kinase-independent function of cyclin E. Molecular Cell. 25: 127-39. PMID 17218276 DOI: 10.1016/j.molcel.2006.11.029  0.44
2006 Neiman PE, Burnside J, Elsaesser K, Hwang H, Clurman BE, Kimmel R, Delrow J. Analysis of gene expression, copy number and palindrome formation with a Dt40 enriched cDNA microarray. Sub-Cellular Biochemistry. 40: 245-56. PMID 17623909  0.44
2006 Gustafson MP, Xu C, Grim JE, Clurman BE, Knudsen BS. Regulation of cell proliferation in a stratified culture system of epithelial cells from prostate tissue. Cell and Tissue Research. 325: 263-76. PMID 16557385 DOI: 10.1007/s00441-005-0093-0  0.44
2005 Gustafson MP, Welcker M, Hwang HC, Clurman BE. Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins. Biochemical and Biophysical Research Communications. 338: 1359-67. PMID 16263084 DOI: 10.1016/j.bbrc.2005.10.090  0.44
2005 Minella AC, Clurman BE. Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle (Georgetown, Tex.). 4: 1356-9. PMID 16131838  0.44
2005 Loeb KR, Kostner H, Firpo E, Norwood T, D Tsuchiya K, Clurman BE, Roberts JM. A mouse model for cyclin E-dependent genetic instability and tumorigenesis. Cancer Cell. 8: 35-47. PMID 16023597 DOI: 10.1016/j.ccr.2005.06.010  0.44
2005 Minella AC, Welcker M, Clurman BE. Ras activity regulates cyclin E degradation by the Fbw7 pathway. Proceedings of the National Academy of Sciences of the United States of America. 102: 9649-54. PMID 15980150 DOI: 10.1073/pnas.0503677102  0.44
2005 Hwang HC, Clurman BE. Cyclin E in normal and neoplastic cell cycles. Oncogene. 24: 2776-86. PMID 15838514 DOI: 10.1038/sj.onc.1208613  0.44
2005 Welcker M, Clurman BE. The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4. The Journal of Biological Chemistry. 280: 7654-8. PMID 15611062 DOI: 10.1074/jbc.M413377200  0.44
2004 Thomas DM, Johnson SA, Sims NA, Trivett MK, Slavin JL, Rubin BP, Waring P, McArthur GA, Walkley CR, Holloway AJ, Diyagama D, Grim JE, Clurman BE, Bowtell DD, Lee JS, et al. Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. The Journal of Cell Biology. 167: 925-34. PMID 15583032 DOI: 10.1083/jcb.200409187  0.44
2004 Chen X, Chi Y, Bloecher A, Aebersold R, Clurman BE, Roberts JM. N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1). Molecular Cell. 16: 839-47. PMID 15574338 DOI: 10.1016/j.molcel.2004.11.011  0.44
2004 Welcker M, Orian A, Grim JE, Grim JA, Eisenman RN, Clurman BE. A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Current Biology : Cb. 14: 1852-7. PMID 15498494 DOI: 10.1016/j.cub.2004.09.083  0.44
2004 Noseda M, Chang L, McLean G, Grim JE, Clurman BE, Smith LL, Karsan A. Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Molecular and Cellular Biology. 24: 8813-22. PMID 15456857 DOI: 10.1128/MCB.24.20.8813-8822.2004  0.44
2004 Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JW. Recognition of phosphodegron motifs in human cyclin E by the SCF Fbw7 ubiquitin ligase Journal of Biological Chemistry. 279: 50110-50119. PMID 15364936 DOI: 10.1074/jbc.M409226200  0.44
2004 Welcker M, Orian A, Jin J, Grim JE, Grim JA, Harper JW, Eisenman RN, Clurman BE. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proceedings of the National Academy of Sciences of the United States of America. 101: 9085-90. PMID 15150404 DOI: 10.1073/pnas.0402770101  0.44
2003 Welcker M, Singer J, Loeb KR, Grim J, Bloecher A, Gurien-West M, Clurman BE, Roberts JM. Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Molecular Cell. 12: 381-92. PMID 14536078 DOI: 10.1016/S1097-2765(03)00287-9  0.44
2003 Grim JE, Clurman BE. Cycling without CDK2? Trends in Cell Biology. 13: 396-9. PMID 12888290 DOI: 10.1016/S0962-8924(03)00148-X  0.44
2003 Grandori C, Wu KJ, Fernandez P, Ngouenet C, Grim J, Clurman BE, Moser MJ, Oshima J, Russell DW, Swisshelm K, Frank S, Amati B, Dalla-Favera R, Monnat RJ. Werner syndrome protein limits MYC-induced cellular senescence Genes and Development. 17: 1569-1574. PMID 12842909 DOI: 10.1101/gad.1100303  0.44
2002 Minella AC, Swanger J, Bryant E, Welcker M, Hwang H, Clurman BE. p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation. Current Biology : Cb. 12: 1817-27. PMID 12419181 DOI: 10.1016/S0960-9822(02)01225-3  0.44
2002 Lindsay ME, Plafker K, Smith AE, Clurman BE, Macara IG. Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import. Cell. 110: 349-60. PMID 12176322 DOI: 10.1016/S0092-8674(02)00836-X  0.44
2002 Hwang HC, Martins CP, Bronkhorst Y, Randel E, Berns A, Fero M, Clurman BE. Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis Proceedings of the National Academy of Sciences of the United States of America. 99: 11293-11298. PMID 12151601 DOI: 10.1073/pnas.162356099  0.44
2000 Smitherman M, Lee K, Swanger J, Kapur R, Clurman BE. Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex. Molecular and Cellular Biology. 20: 5631-42. PMID 10891500 DOI: 10.1128/MCB.20.15.5631-5642.2000  0.44
2000 Guan T, Kehlenbach RH, Schirmer EC, Kehlenbach A, Fan F, Clurman BE, Arnheim N, Gerace L. Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export. Molecular and Cellular Biology. 20: 5619-30. PMID 10891499 DOI: 10.1128/MCB.20.15.5619-5630.2000  0.44
2000 Sheaff RJ, Singer JD, Swanger J, Smitherman M, Roberts JM, Clurman BE. Proteasomal turnover of p21(Cip1) does not require p21(Cip1) ubiquitination Molecular Cell. 5: 403-410. PMID 10882081  0.44
1998 Clurman BE, Porter P. New insights into the tumor suppression function of p27(kip1) Proceedings of the National Academy of Sciences of the United States of America. 95: 15158-15160. PMID 9860936 DOI: 10.1073/pnas.95.26.15158  0.44
1998 Levkau B, Koyama H, Raines EW, Clurman BE, Herren B, Orth K, Roberts JM, Ross R. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of cdk2: Role of a caspase cascade Molecular Cell. 1: 553-563. PMID 9660939  0.44
1998 Clurman BE, Groudine M. The CDKN2A tumor-suppressor logus - A tale of two proteins New England Journal of Medicine. 338: 910-912. PMID 9516230 DOI: 10.1056/NEJM199803263381312  0.44
1997 Neiman PE, Clurman BE, Lobanenkov VV. Molecular pathogenesis of myc-initiated B-cell lymphomas in the bursa of Fabricius Current Topics in Microbiology and Immunology. 224: 231-238. PMID 9308246  0.44
1997 Sheaff RJ, Groudine M, Gordon M, Roberts JM, Clurman BE. Cyclin E-CDK2 is a regulator of p27(Kip1) Genes and Development. 11: 1464-1478. PMID 9192873  0.44
1996 Clurman BE, Roberts JM, Groudine M. Deregulation of cell cycle control in hematologic malignancies Current Opinion in Hematology. 3: 315-320. PMID 9372094  0.44
1996 Clurman BE, Sheaff RJ, Thress K, Groudine M, Roberts JM. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation Genes and Development. 10: 1979-1990. PMID 8769642  0.44
1995 Clurman BE, Roberts JM. Cell cycle and cancer Journal of the National Cancer Institute. 87: 1499-1501. PMID 7563177 DOI: 10.1093/jnci/87.20.1499  0.44
1989 Clurman BE, Hayward WS. Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events. Molecular and Cellular Biology. 9: 2657-64. PMID 2548084  0.44
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