| Year |
Citation |
Score |
| 2020 |
Gao X, Cheng YH, Enten GA, DeSantis AJ, Gaponenko V, Majetschak M. Regulation of the thrombin/protease-activated receptor 1 axis by chemokine (C-X-C motif) receptor 4. The Journal of Biological Chemistry. PMID 32839271 DOI: 10.1074/Jbc.Ra120.015355 |
0.38 |
|
| 2020 |
Abdelkarim H, Hitchinson B, Qu X, Banerjee A, Komarova YA, Gaponenko V. NMR resonance assignment and structure prediction of the C-terminal domain of the microtubule end-binding protein 3. Plos One. 15: e0232338. PMID 32421702 DOI: 10.1371/Journal.Pone.0232338 |
0.405 |
|
| 2020 |
Gao X, Enten GA, DeSantis AJ, Volkman BF, Gaponenko V, Majetschak M. Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays. Biochemical and Biophysical Research Communications. PMID 32085899 DOI: 10.1016/J.Bbrc.2020.02.094 |
0.321 |
|
| 2019 |
Abdelkarim H, Banerjee A, Grudzien P, Leschinsky N, Abushaer M, Gaponenko V. The Hypervariable Region of K-Ras4B Governs Molecular Recognition and Function. International Journal of Molecular Sciences. 20. PMID 31739603 DOI: 10.3390/Ijms20225718 |
0.399 |
|
| 2019 |
Abdelkarim H, Hitchinson B, Banerjee A, Gaponenko V. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands. Advances in Experimental Medicine and Biology. 1163: 171-186. PMID 31707704 DOI: 10.1007/978-981-13-8719-7_8 |
0.344 |
|
| 2019 |
Jang H, Banerjee A, Marcus K, Makowski L, Mattos C, Gaponenko V, Nussinov R. The Structural Basis of the Farnesylated and Methylated KRas4B Interaction with Calmodulin. Structure (London, England : 1993). PMID 31495533 DOI: 10.1016/J.Str.2019.08.009 |
0.363 |
|
| 2019 |
Wozniak DJ, Hitchinson B, Gilic M, Bie W, Gaponenko V, Tyner AL. Vemurafenib Inhibits Active PTK6 in PTEN-null Prostate Tumor Cells. Molecular Cancer Therapeutics. PMID 30926642 DOI: 10.1158/1535-7163.Mct-18-0862 |
0.307 |
|
| 2018 |
Hitchinson B, Eby JM, Gao X, Guite-Vinet F, Ziarek JJ, Abdelkarim H, Lee Y, Okamoto Y, Shikano S, Majetschak M, Heveker N, Volkman BF, Tarasova NI, Gaponenko V. Biased antagonism of CXCR4 avoids antagonist tolerance. Science Signaling. 11. PMID 30327409 DOI: 10.1126/Scisignal.Aat2214 |
0.566 |
|
| 2018 |
Biancucci M, Minasov G, Banerjee A, Herrera A, Woida PJ, Kieffer MB, Bindu L, Abreu-Blanco M, Anderson WF, Gaponenko V, Stephen AG, Holderfield M, Satchell KJF. The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling. Science Signaling. 11. PMID 30279169 DOI: 10.1126/Scisignal.Aat8335 |
0.358 |
|
| 2018 |
Gao X, Abdelkarim H, Albee LJ, Volkman BF, Gaponenko V, Majetschak M. Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3. Plos One. 13: e0204041. PMID 30248140 DOI: 10.1371/Journal.Pone.0204041 |
0.349 |
|
| 2018 |
Zhang M, Li Z, Wang G, Jang H, Sacks D, Zhang J, Gaponenko V, Nussinov R. Calmodulin (CaM) Activates PI3Kα by Targeting the "Soft" CaM-Binding Motifs in Both the nSH2 and cSH2 Domains of p85α. The Journal of Physical Chemistry. B. PMID 30047727 DOI: 10.1021/Acs.Jpcb.8B05982 |
0.383 |
|
| 2018 |
Procter DJ, Banerjee A, Nukui M, Kruse K, Gaponenko V, Murphy EA, Komarova Y, Walsh D. The HCMV Assembly Compartment Is a Dynamic Golgi-Derived MTOC that Controls Nuclear Rotation and Virus Spread. Developmental Cell. 45: 83-100.e7. PMID 29634939 DOI: 10.1016/J.Devcel.2018.03.010 |
0.312 |
|
| 2018 |
Wang G, Zhang M, Jang H, Lu S, Lin S, Chen GQ, Nussinov R, Zhang J, Gaponenko V. Interaction of Calmodulin with the cSH2 Domain of the p85 Regulatory Subunit. Biochemistry. PMID 29494137 DOI: 10.1021/Acs.Biochem.7B01130 |
0.368 |
|
| 2018 |
Gao X, Albee LJ, Volkman BF, Gaponenko V, Majetschak M. Asymmetrical ligand-induced cross-regulation of chemokine (C-X-C motif) receptor 4 by α1-adrenergic receptors at the heteromeric receptor complex. Scientific Reports. 8: 2730. PMID 29426850 DOI: 10.1038/S41598-018-21096-4 |
0.344 |
|
| 2018 |
Albee LJ, LaPorte HM, Gao X, Eby JM, Cheng YH, Nevins AM, Volkman BF, Gaponenko V, Majetschak M. Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle. Open Biology. 8. PMID 29386406 DOI: 10.1098/Rsob.170207 |
0.345 |
|
| 2018 |
Halasi M, Hitchinson B, Shah BN, Váraljai R, Khan I, Benevolenskaya EV, Gaponenko V, Arbiser JL, Gartel AL. Honokiol is a FOXM1 antagonist. Cell Death & Disease. 9: 84. PMID 29367668 DOI: 10.1038/S41419-017-0156-7 |
0.338 |
|
| 2017 |
Zhang M, Jang H, Gaponenko V, Nussinov R. Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH2 Domains. Biophysical Journal. 113: 1956-1967. PMID 29117520 DOI: 10.1016/J.Bpj.2017.09.008 |
0.404 |
|
| 2017 |
Albee LJ, Eby JM, Tripathi A, LaPorte HM, Gao X, Volkman BF, Gaponenko V, Majetschak M. α1-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells. Journal of the American Heart Association. 6. PMID 28862946 DOI: 10.1161/Jaha.117.006575 |
0.311 |
|
| 2017 |
Jang H, Banerjee A, Chavan T, Gaponenko V, Nussinov R. Flexible-Body Motions of Calmodulin and the Farnesylated Hypervariable Region Yield a High-Affinity Interaction Enabling K-Ras4B Membrane Extraction. The Journal of Biological Chemistry. PMID 28623230 DOI: 10.1074/Jbc.M117.785063 |
0.393 |
|
| 2017 |
Nussinov R, Wang G, Tsai CJ, Jang H, Lu S, Banerjee A, Zhang J, Gaponenko V. Calmodulin and PI3K Signaling in KRAS Cancers. Trends in Cancer. 3: 214-224. PMID 28462395 DOI: 10.1016/J.Trecan.2017.01.007 |
0.375 |
|
| 2017 |
Eby JM, Abdelkarim H, Albee LJ, Tripathi A, Gao X, Volkman BF, Gaponenko V, Majetschak M. Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists. Molecular and Cellular Biochemistry. PMID 28455789 DOI: 10.1007/S11010-017-3044-7 |
0.383 |
|
| 2017 |
Jang H, Banerjee A, Gaponenko V, Nussinov R. Abstract 5229: High affinity interaction of K-Ras4B HVR with calmodulin Cancer Research. 77: 5229-5229. DOI: 10.1158/1538-7445.Am2017-5229 |
0.407 |
|
| 2016 |
Evans AE, Tripathi A, LaPorte HM, Brueggemann LI, Singh AK, Albee LJ, Byron KL, Tarasova NI, Volkman BF, Cho TY, Gaponenko V, Majetschak M. New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle. International Journal of Molecular Sciences. 17. PMID 27331810 DOI: 10.3390/Ijms17060971 |
0.366 |
|
| 2016 |
Wozniak DJ, Hitchinson B, Bie W, Gaponenko V, Tyner AL. Abstract 197: Phospholipids regulate the localization and oncogenic potential of protein tyrosine kinase 6 in prostate cancer Cancer Research. 76: 197-197. DOI: 10.1158/1538-7445.Am2016-197 |
0.352 |
|
| 2015 |
Chavan TS, Muratcioglu S, Marszalek R, Jang H, Keskin O, Gursoy A, Nussinov R, Gaponenko V. Plasma membrane regulates Ras signaling networks. Cellular Logistics. 5: e1136374. PMID 27054048 DOI: 10.1080/21592799.2015.1136374 |
0.33 |
|
| 2015 |
Jang H, Banerjee A, Chavan TS, Lu S, Zhang J, Gaponenko V, Nussinov R. The higher level of complexity of K-Ras4B activation at the membrane. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26718888 DOI: 10.1096/Fj.15-279091 |
0.364 |
|
| 2015 |
Banerjee A, Jang H, Nussinov R, Gaponenko V. The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding. Current Opinion in Structural Biology. 36: 10-17. PMID 26709496 DOI: 10.1016/J.Sbi.2015.11.010 |
0.379 |
|
| 2015 |
Chavan TS, Jang H, Khavrutskii L, Abraham SJ, Banerjee A, Freed BC, Johannessen L, Tarasov SG, Gaponenko V, Nussinov R, Tarasova NI. High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site. Biophysical Journal. 109: 2602-13. PMID 26682817 DOI: 10.1016/J.Bpj.2015.09.034 |
0.443 |
|
| 2015 |
Lu S, Banerjee A, Jang H, Zhang J, Gaponenko V, Nussinov R. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase KRAS4B, Exposing the Effector Binding Site. The Journal of Biological Chemistry. PMID 26453300 DOI: 10.1074/Jbc.M115.664755 |
0.392 |
|
| 2015 |
Muratcioglu S, Chavan TS, Freed BC, Jang H, Khavrutskii L, Freed RN, Dyba MA, Stefanisko K, Tarasov SG, Gursoy A, Keskin O, Tarasova NI, Gaponenko V, Nussinov R. GTP-Dependent K-Ras Dimerization. Structure (London, England : 1993). 23: 1325-35. PMID 26051715 DOI: 10.7490/F1000Research.1110253.1 |
0.404 |
|
| 2015 |
Tripathi A, Vana PG, Chavan TS, Brueggemann LI, Byron KL, Tarasova NI, Volkman BF, Gaponenko V, Majetschak M. Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function. Proceedings of the National Academy of Sciences of the United States of America. 112: E1659-68. PMID 25775528 DOI: 10.1073/Pnas.1417564112 |
0.359 |
|
| 2015 |
Jang H, Abraham SJ, Chavan TS, Hitchinson B, Khavrutskii L, Tarasova NI, Nussinov R, Gaponenko V. Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region. The Journal of Biological Chemistry. 290: 9465-77. PMID 25713064 DOI: 10.1074/Jbc.M114.620724 |
0.377 |
|
| 2015 |
Jang H, Abraham SJ, Chavan TS, Hitchinson B, Khavrutskii L, Tarasova NI, Nussinov R, Gaponenko V. Abstract 2457: Mechanisms of membrane binding of K-Ras4B farnesylated hypervariable region Cancer Research. 75: 2457-2457. DOI: 10.1158/1538-7445.Am2015-2457 |
0.381 |
|
| 2015 |
Jang H, Lu S, Chakrabarti M, Khavrutskii L, Tarasova NI, Gaponenko V, Nussinov R. Nucleotide-Dependent Membrane Interaction and Dimerization of K-Ras4B Biophysical Journal. 108: 93a-94a. DOI: 10.1016/J.Bpj.2014.11.542 |
0.422 |
|
| 2015 |
Chakrabarti M, Lu S, Jang H, Khavrutskii L, Tarasova NI, Gaponenko V, Nussinov R. Elucidating the Functional Significance of the C-Terminal Hypervariable Region (HVR) in K-Ras4A Biophysical Journal. 108: 210a-211a. DOI: 10.1016/J.Bpj.2014.11.1165 |
0.405 |
|
| 2014 |
Chavan TS, Meyer JO, Chisholm L, Dobosz-Bartoszek M, Gaponenko V. A novel method for the production of fully modified K-Ras 4B. Methods in Molecular Biology (Clifton, N.J.). 1120: 19-32. PMID 24470016 DOI: 10.1007/978-1-62703-791-4_2 |
0.41 |
|
| 2014 |
Chavan TS, Jang H, Khavrutskii L, Freed BC, Johannessen L, Tarasov SG, Abraham SJ, Gaponenko V, Nussinov R, Tarasova N. Abstract 3224: High affinity interaction of K-Ras4B hypervariable region with Ras active site Cancer Research. 74: 3224-3224. DOI: 10.1158/1538-7445.Am2014-3224 |
0.443 |
|
| 2013 |
Abdelkarim H, Brunsteiner M, Neelarapu R, Bai H, Madriaga A, van Breemen RB, Blond SY, Gaponenko V, Petukhov PA. Photoreactive "nanorulers" detect a novel conformation of full length HDAC3-SMRT complex in solution. Acs Chemical Biology. 8: 2538-49. PMID 24010878 DOI: 10.1021/Cb400601G |
0.327 |
|
| 2013 |
Chavan TS, Abraham S, Gaponenko V. Application of reductive ¹³C-methylation of lysines to enhance the sensitivity of conventional NMR methods. Molecules (Basel, Switzerland). 18: 7103-19. PMID 23778120 DOI: 10.3390/Molecules18067103 |
0.387 |
|
| 2013 |
Yar S, Chowdhury SA, Davis RT, Kobayashi M, Monasky MM, Rajan S, Wolska BM, Gaponenko V, Kobayashi T, Wieczorek DF, Solaro RJ. Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L. The Journal of Biological Chemistry. 288: 16235-46. PMID 23609439 DOI: 10.1074/Jbc.M113.458695 |
0.313 |
|
| 2013 |
Yar S, Chowdhury SA, Turner M, Rajan S, Wolska BM, Gaponenko V, Debold EP, Kobayashi T, Wieczorek DF, Solaro RJ. Altered Flexibility affects Regulatory Functions of Cardiac α-Tropomyosin (α-Tm) in a Novel Transgenic Mouse Model Expressing α-Tm-D137L Biophysical Journal. 104: 448a. DOI: 10.1016/J.Bpj.2012.11.2485 |
0.336 |
|
| 2012 |
Johannessen L, Remsberg JR, Ivanova A, Gaponenko V, Khavrutskii L, Tarasov SG, Dean M, Kates J, Tarasova NI. Abstract LB-426: Potent inhibitors of RAS pathways that bind directly to Ras proteins Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-426 |
0.394 |
|
| 2011 |
Lee Y, Chen Y, Tarasova NI, Gaponenko V. The structure of monomeric components of self-assembling CXCR4 antagonists determines the architecture of resulting nanostructures. Nanotechnology. 22: 505101. PMID 22107755 DOI: 10.1088/0957-4484/22/50/505101 |
0.55 |
|
| 2011 |
Tarasov SG, Gaponenko V, Howard OM, Chen Y, Oppenheim JJ, Dyba MA, Subramaniam S, Lee Y, Michejda C, Tarasova NI. Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles. Proceedings of the National Academy of Sciences of the United States of America. 108: 9798-803. PMID 21628584 DOI: 10.1073/Pnas.1014598108 |
0.548 |
|
| 2011 |
Johannessen L, Remsberg J, Gaponenko V, Adams KM, Barchi JJ, Tarasov SG, Jiang S, Tarasova NI. Peptide structure stabilization by membrane anchoring and its general applicability to the development of potent cell-permeable inhibitors. Chembiochem : a European Journal of Chemical Biology. 12: 914-21. PMID 21365731 DOI: 10.1002/Cbic.201000563 |
0.376 |
|
| 2011 |
Sacco E, Abraham SJ, Palmioli A, Damore G, Bargna A, Mazzoleni E, Gaponenko V, Vanoni M, Peri F. Binding properties and biological characterization of new sugar-derived Ras ligands Medchemcomm. 2: 396-401. DOI: 10.1039/C0Md00264J |
0.324 |
|
| 2010 |
Abraham SJ, Muhamed I, Nolet R, Yeung F, Gaponenko V. Expression, purification, and characterization of soluble K-Ras4B for structural analysis. Protein Expression and Purification. 73: 125-31. PMID 20566322 DOI: 10.1016/J.Pep.2010.05.015 |
0.33 |
|
| 2009 |
Abraham SJ, Nolet RP, Calvert RJ, Anderson LM, Gaponenko V. The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin. Biochemistry. 48: 7575-83. PMID 19583261 DOI: 10.1021/Bi900769J |
0.409 |
|
| 2009 |
Palmioli A, Sacco E, Abraham S, Thomas CJ, Di Domizio A, De Gioia L, Gaponenko V, Vanoni M, Peri F. First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand. Bioorganic & Medicinal Chemistry Letters. 19: 4217-22. PMID 19515561 DOI: 10.1016/J.Bmcl.2009.05.107 |
0.325 |
|
| 2009 |
Abraham SJ, Kobayashi T, Solaro RJ, Gaponenko V. Differences in lysine pKa values may be used to improve NMR signal dispersion in reductively methylated proteins. Journal of Biomolecular Nmr. 43: 239-46. PMID 19280122 DOI: 10.1007/S10858-009-9306-2 |
0.305 |
|
| 2008 |
Abraham SJ, Hoheisel S, Gaponenko V. Detection of protein-ligand interactions by NMR using reductive methylation of lysine residues. Journal of Biomolecular Nmr. 42: 143-8. PMID 18819009 DOI: 10.1007/S10858-008-9274-Y |
0.332 |
|
| 2007 |
Timofeeva OA, Gaponenko V, Lockett SJ, Tarasov SG, Jiang S, Michejda CJ, Perantoni AO, Tarasova NI. Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. Acs Chemical Biology. 2: 799-809. PMID 18154267 DOI: 10.1021/Cb700186X |
0.345 |
|
| 2004 |
Gaponenko V, Sarma SP, Altieri AS, Horita DA, Li J, Byrd RA. Improving the accuracy of NMR structures of large proteins using pseudocontact shifts as long-range restraints. Journal of Biomolecular Nmr. 28: 205-12. PMID 14752254 DOI: 10.1023/B:Jnmr.0000013706.09264.36 |
0.32 |
|
| 2002 |
Gaponenko V, Altieri AS, Li J, Byrd RA. Breaking symmetry in the structure determination of (large) symmetric protein dimers. Journal of Biomolecular Nmr. 24: 143-8. PMID 12495030 DOI: 10.1023/A:1020948529076 |
0.301 |
|
| 2000 |
Gaponenko V, Dvoretsky A, Walsby C, Hoffman BM, Rosevear PR. Calculation of z-coordinates and orientational restraints using a metal binding tag Biochemistry. 39: 15217-15224. PMID 11106501 DOI: 10.1021/Bi001381W |
0.32 |
|
| 2000 |
Abbott MB, Gaponenko V, Abusamhadneh E, Finley N, Li G, Dvoretsky A, Rance M, Solaro RJ, Rosevear PR. Regulatory domain conformational exchange and linker region flexibility in cardiac troponin C bound to cardiac troponin I. The Journal of Biological Chemistry. 275: 20610-7. PMID 10801883 DOI: 10.1074/Jbc.M909252199 |
0.314 |
|
| 2000 |
Abbott MB, Dvoretsky A, Gaponenko V, Rosevear PR. Cardiac troponin I inhibitory peptide: Location of interaction sites on troponin C Febs Letters. 469: 168-172. PMID 10713265 DOI: 10.1016/S0014-5793(00)01271-0 |
0.358 |
|
| 1999 |
Gasmi-Seabrook GM, Howarth JW, Finley N, Abusamhadneh E, Gaponenko V, Brito RM, Solaro RJ, Rosevear PR. Solution structures of the C-terminal domain of cardiac troponin C free and bound to the N-terminal domain of cardiac troponin I. Biochemistry. 38: 8313-22. PMID 10387077 DOI: 10.1021/Bi9902642 |
0.363 |
|
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