Pavel A. Petukhov - Publications

Affiliations: 
Medicinal Chemistry and Pharmacognosy University of Illinois at Chicago, Chicago, IL, United States 
Area:
Pharmaceutical Chemistry, Pharmacy

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Taha TY, Aboukhatwa SM, Knopp RC, Ikegaki N, Abdelkarim H, Neerasa J, Lu Y, Neelarapu R, Hanigan TW, Thatcher GRJ, Petukhov PA. Correction to Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors. Acs Medicinal Chemistry Letters. 10: 1358. PMID 31531211 DOI: 10.1021/acsmedchemlett.9b00336  0.48
2017 Petukhov PA, Abdelkarim H, Neelarapu R, Madriaga A, Kastrati I, Wang YT, Vaidya AS, Taha TY, Thatcher GRJ, Frasor J. Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine-based Histone Deacetylase Inhibitors. Chemmedchem. PMID 29080240 DOI: 10.1002/cmdc.201700449  0.48
2017 Taha TY, Aboukhatwa SM, Knopp RC, Ikegaki N, Abdelkarim H, Neerasa J, Lu Y, Neelarapu R, Hanigan TW, Thatcher GRJ, Petukhov PA. Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors. Acs Medicinal Chemistry Letters. 8: 824-829. PMID 28835796 DOI: 10.1021/acsmedchemlett.7b00126  0.48
2016 Petiwala SM, Li G, Bosland MC, Lantvit DD, Petukhov PA, Johnson JJ. Carnosic acid promotes degradation of the androgen receptor and is regulated by the unfolded protein response pathway in vitro and in vivo. Carcinogenesis. PMID 27267997 DOI: 10.1093/carcin/bgw052  0.48
2016 Li G, Petiwala SM, Yan M, Won JH, Petukhov PA, Johnson JJ. Gartanin, an isoprenylated xanthone from the mangosteen fruit (Garcinia mangostana), is an androgen receptor degradation enhancer. Molecular Nutrition & Food Research. PMID 27019217 DOI: 10.1002/mnfr.201600037  0.48
2015 Fà M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O. Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26484927 DOI: 10.3233/JAD-150618  0.48
2014 Toh MF, Mendonca E, Eddie SL, Endsley MP, Lantvit DD, Petukhov PA, Burdette JE. Kaempferol Exhibits Progestogenic Effects in Ovariectomized Rats. Journal of Steroids & Hormonal Science. 5: 136. PMID 25844270 DOI: 10.4172/2157-7536.1000136  0.48
2014 Patel HK, Siklos MI, Abdelkarim H, Mendonca EL, Vaidya A, Petukhov PA, Thatcher GR. A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy. Chemmedchem. 9: 602-13. PMID 23956109 DOI: 10.1002/cmdc.201300270  0.48
2013 Abdelkarim H, Brunsteiner M, Neelarapu R, Bai H, Madriaga A, van Breemen RB, Blond SY, Gaponenko V, Petukhov PA. Photoreactive "nanorulers" detect a novel conformation of full length HDAC3-SMRT complex in solution. Acs Chemical Biology. 8: 2538-49. PMID 24010878 DOI: 10.1021/cb400601g  0.48
2013 Schiefer IT, Tapadar S, Litosh V, Siklos M, Scism R, Wijewickrama GT, Chandrasena EP, Sinha V, Tavassoli E, Brunsteiner M, Fa' M, Arancio O, Petukhov P, Thatcher GR. Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of Medicinal Chemistry. 56: 6054-68. PMID 23834438 DOI: 10.1021/jm4006719  0.48
2012 Vaidya AS, Neelarapu R, Madriaga A, Bai H, Mendonca E, Abdelkarim H, van Breemen RB, Blond SY, Petukhov PA. Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. Bioorganic & Medicinal Chemistry Letters. 22: 6621-7. PMID 23010266 DOI: 10.1016/j.bmcl.2012.08.104  0.48
2012 Yu X, Sainz B, Petukhov PA, Uprichard SL. Identification of hepatitis C virus inhibitors targeting different aspects of infection using a cell-based assay. Antimicrobial Agents and Chemotherapy. 56: 6109-20. PMID 22948883 DOI: 10.1128/AAC.01413-12  0.48
2012 Neelarapu R, Petukhov PA. A One-Pot Selective Synthesis of N-Boc Protected Secondary Amines: Tandem Direct Reductive Amination/N-Boc Protection. Tetrahedron. 68: 7056-7062. PMID 22844160 DOI: 10.1016/j.tet.2012.06.055  0.48
2012 Vaidya AS, Karumudi B, Mendonca E, Madriaga A, Abdelkarim H, van Breemen RB, Petukhov PA. Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2. Bioorganic & Medicinal Chemistry Letters. 22: 5025-30. PMID 22771007 DOI: 10.1016/j.bmcl.2012.06.017  0.48
2012 Brunsteiner M, Petukhov PA. Insights from comprehensive multiple receptor docking to HDAC8. Journal of Molecular Modeling. 18: 3927-39. PMID 22431224 DOI: 10.1007/s00894-011-1297-8  0.48
2011 Danilov SM, Gordon K, Nesterovitch AB, Lünsdorf H, Chen Z, Castellon M, Popova IA, Kalinin S, Mendonca E, Petukhov PA, Schwartz DE, Minshall RD, Sturrock ED. An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding. Plos One. 6: e25952. PMID 21998728 DOI: 10.1371/journal.pone.0025952  0.48
2011 Nesterovitch AB, Hoffman MD, Simon M, Petukhov PA, Tharp MD, Glant TT. Mutations in the PSTPIP1 gene and aberrant splicing variants in patients with pyoderma gangrenosum. Clinical and Experimental Dermatology. 36: 889-95. PMID 21790734 DOI: 10.1111/j.1365-2230.2011.04137.x  0.48
2011 Neelarapu R, Holzle DL, Velaparthi S, Bai H, Brunsteiner M, Blond SY, Petukhov PA. Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. Journal of Medicinal Chemistry. 54: 4350-64. PMID 21548582 DOI: 10.1021/jm2001025  0.48
2009 He B, Velaparthi S, Pieffet G, Pennington C, Mahesh A, Holzle DL, Brunsteiner M, van Breemen R, Blond SY, Petukhov PA. Binding ensemble profiling with photoaffinity labeling (BEProFL) approach: mapping the binding poses of HDAC8 inhibitors. Journal of Medicinal Chemistry. 52: 7003-13. PMID 19886628 DOI: 10.1021/jm9005077  0.48
2009 Pieffet G, Petukhov PA. Parameterization of aromatic azido groups: application as photoaffinity probes in molecular dynamics studies. Journal of Molecular Modeling. 15: 1291-7. PMID 19288146 DOI: 10.1007/s00894-009-0488-z  0.48
2009 Chirapu SR, Pachaiyappan B, Nural HF, Cheng X, Yuan H, Lankin DC, Abdul-Hay SO, Thatcher GR, Shen Y, Kozikowski AP, Petukhov PA. Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 264-74. PMID 19013792 DOI: 10.1016/j.bmcl.2008.10.096  0.48
2008 Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Advances in Experimental Medicine and Biology. 617: 601-7. PMID 18497087 DOI: 10.1007/978-0-387-69080-3_62  0.48
2008 Zaheer-ul H, Uddin R, Yuan H, Petukhov PA, Choudhary MI, Madura JD. Receptor-based modeling and 3D-QSAR for a quantitative production of the butyrylcholinesterase inhibitors based on genetic algorithm. Journal of Chemical Information and Modeling. 48: 1092-103. PMID 18444627 DOI: 10.1021/ci8000056  0.48
2008 Velaparthi S, Brunsteiner M, Uddin R, Wan B, Franzblau SG, Petukhov PA. 5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs. Journal of Medicinal Chemistry. 51: 1999-2002. PMID 18335974 DOI: 10.1021/jm701372r  0.48
2007 Gills JJ, Castillo SS, Zhang C, Petukhov PA, Memmott RM, Hollingshead M, Warfel N, Han J, Kozikowski AP, Dennis PA. Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38α, through MKK3/6-independent and -dependent mechanisms Journal of Biological Chemistry. 282: 27020-27029. PMID 17631503 DOI: 10.1074/jbc.M701108200  0.48
2007 Kozikowski AP, Gaisina IN, Yuan H, Petukhov PA, Blond SY, Fedolak A, Caldarone B, McGonigle P. Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders. Journal of the American Chemical Society. 129: 8328-32. PMID 17552518 DOI: 10.1021/ja068969w  0.48
2007 Kozikowski AP, Chellappan SK, Xiao Y, Bajjuri KM, Yuan H, Kellar KJ, Petukhov PA. Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors. Chemmedchem. 2: 1157-61. PMID 17530728 DOI: 10.1002/cmdc.200700073  0.48
2007 Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, Thatcher GR. Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. Journal of Medicinal Chemistry. 50: 2682-92. PMID 17489582 DOI: 10.1021/jm070079j  0.48
2006 Yuan H, Petukhov PA. Improved 3D-QSAR CoMFA of the dopamine transporter blockers with multiple conformations using the genetic algorithm. Bioorganic & Medicinal Chemistry Letters. 16: 6267-72. PMID 17027270 DOI: 10.1016/j.bmcl.2006.09.037  0.48
2006 Yuan H, Petukhov PA. Computational evidence for the ligand selectivity to the alpha4beta2 and alpha3beta4 nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry. 14: 7936-42. PMID 16919961 DOI: 10.1016/j.bmc.2006.07.049  0.48
2006 Kozikowski AP, Gaisina IN, Petukhov PA, Sridhar J, King LT, Blond SY, Duka T, Rusnak M, Sidhu A. Highly potent and specific GSK-3β inhibitors that block tau phosphorylation and decrease α-synuclein protein expression in a cellular model of Parkinson's disease Chemmedchem. 1: 256-266. PMID 16892358 DOI: 10.1002/cmdc.200500039  0.48
2005 Jung M, Velena A, Chen B, Petukhov PA, Kozikowski AP, Dritschilo A. Novel HDAC inhibitors with radiosensitizing properties Radiation Research. 163: 488-493. PMID 15850409 DOI: 10.1667/RR3345  0.48
2005 Wei ZL, Xiao Y, Yuan H, Baydyuk M, Petukhov PA, Musachio JL, Kellar KJ, Kozikowski AP. Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits. Journal of Medicinal Chemistry. 48: 1721-4. PMID 15771418 DOI: 10.1021/jm0492406  0.48
2005 Chen B, Petukhov PA, Jung M, Velena A, Eliseeva E, Dritschilo A, Kozikowski AP. Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors Bioorganic and Medicinal Chemistry Letters. 15: 1389-1392. PMID 15713393 DOI: 10.1016/j.bmcl.2005.01.006  0.48
2004 Wei ZL, Petukhov PA, Bizik F, Teixeira JC, Mercola M, Volpe EA, Glazer RI, Willson TM, Kozikowski AP. Isoxazolyl-serine-based agonists of peroxisome proliferator-activated receptor: design, synthesis, and effects on cardiomyocyte differentiation. Journal of the American Chemical Society. 126: 16714-5. PMID 15612696 DOI: 10.1021/ja046386l  0.48
2004 Yuan H, Kozikowski AP, Petukhov PA. CoMFA study of piperidine analogues of cocaine at the dopamine transporter: Exploring the binding mode of the 3α-substituent of the piperidine ring using pharmacophore-based flexible alignment Journal of Medicinal Chemistry. 47: 6137-6143. PMID 15566285 DOI: 10.1021/jm049544s  0.48
2004 Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM. Evodiamine functions as an agonist for the vanilloid receptor TRPV1 Organic and Biomolecular Chemistry. 2: 2281-2286. PMID 15305207 DOI: 10.1039/b404506h  0.48
2004 Petukhov PA, Zhang J, Wang CZ, Ye YP, Johnson KM, Kozikowski AP. Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: evidence of unfavorable interactions proximal to the 3alpha-position of the piperidine ring. Journal of Medicinal Chemistry. 47: 3009-18. PMID 15163183 DOI: 10.1021/jm0303296  0.48
2004 Castillo SS, Brognard J, Petukhov PA, Zhang C, Tsurutani J, Granville CA, Li M, Jung M, West KA, Gills JG, Kozikowski AP, Dennis PA. Preferential Inhibition of Akt and Killing of Akt-Dependent Cancer Cells by Rationally Designed Phosphatidylinositol Ether Lipid Analogues Cancer Research. 64: 2782-2792. PMID 15087394 DOI: 10.1158/0008-5472.CAN-03-1530  0.48
2004 Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. Journal of Medicinal Chemistry. 47: 1729-38. PMID 15027864 DOI: 10.1021/jm0306226  0.48
2004 Li Q, Jin C, Petukhov PA, Rukavishnikov AV, Zaikova TO, Phadke A, LaMunyon DH, Lee MD, Keana JF. Synthesis of well-defined tower-shaped 1,3,5-trisubstituted adamantanes incorporating a macrocyclic trilactam ring system. The Journal of Organic Chemistry. 69: 1010-9. PMID 14961648 DOI: 10.1021/jo035640+  0.48
2003 Li Q, Rukavishnikov AV, Petukhov PA, Zaikova TO, Jin C, Keana JF. Nanoscale tripodal 1,3,5,7-tetrasubstituted adamantanes for AFM applications. The Journal of Organic Chemistry. 68: 4862-9. PMID 12790592 DOI: 10.1021/jo026923p  0.48
2003 Wei ZL, Petukhov PA, Xiao Y, Tückmantel W, George C, Kellar KJ, Kozikowski AP. Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues. Journal of Medicinal Chemistry. 46: 921-4. PMID 12620069 DOI: 10.1021/jm025613w  0.48
2003 Kozikowski AP, Nowak I, Petukhov PA, Etcheberrigaray R, Mohamed A, Tan M, Lewin N, Hennings H, Pearce LL, Blumberg PM. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα Journal of Medicinal Chemistry. 46: 364-373. PMID 12540236 DOI: 10.1021/jm020350r  0.48
2002 Li Q, Rukavishnikov AV, Petukhov PA, Zaikova TO, Keana JF. Nanoscale 1,3,5,7-tetrasubstituted adamantanes and p-substituted tetraphenyl-methanes for AFM applications. Organic Letters. 4: 3631-4. PMID 12375905 DOI: 10.1021/ol026495+  0.48
2002 Woolverton WL, Ranaldi R, Wang Z, Ordway GA, Paul IA, Petukhov P, Kozikowski A. Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 303: 211-7. PMID 12235253 DOI: 10.1124/jpet.102.037812  0.48
2002 Petukhov PA, Zhang J, Kozikowski AP, Wang CZ, Ye YP, Johnson KM, Tella SR. SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement. Journal of Medicinal Chemistry. 45: 3161-70. PMID 12109901 DOI: 10.1021/jm0200153  0.48
2002 Wei ZL, Sakamuri S, Petukhov PA, George C, Lewin NE, Blumberg PM, Kozikowski AP. Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-Hydroxy-8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators Organic Letters. 4: 2169-2172. PMID 12074659 DOI: 10.1021/ol026013u  0.48
2001 Petukhov PA, Zhang M, Johnson KJ, Tella SR, Kozikowski AP. SAR studies of piperidine-based analogues of cocaine. Part 3: Oxadiazoles Bioorganic and Medicinal Chemistry Letters. 11: 2079-2083. PMID 11514143 DOI: 10.1016/S0960-894X(01)00379-1  0.48
2001 Petukhov PA, Bizyaev SN, Tkachev AV. Synthesis of α-amino oximes and bis-α-amino oximes from the monoterpene hydrocarbons 3-carene and α-pinene and α,α-diamines Russian Chemical Bulletin. 50: 2106-2112. DOI: 10.1023/A:1015097200993  0.48
2000 Petukhov PA. Novel terpene-based chiral bis-α-aminooximes and the corresponding macrocycles: X-ray structure of a ring-fused 5,7-dioxa-1,4,8,11-tetraazacyclotrideca-3,8-diene derivative Mendeleev Communications. 10: 209-210. DOI: 10.1070/MC2000v010n06ABEH001346  0.48
2000 Kirin VP, Maksakov VA, Virovets AV, Petukhov PA, Popov SA, Tkachev AV. Synthesis of optically active hydridocarbonyl triosmium clusters with terpene derivatives as ligands. Molecular structure and absolute configuration of a cluster with a bridging dihydroimidazole ligand Russian Chemical Bulletin. 49: 1440-1447.  0.48
2000 Maksakov VA, Kirin VP, Petukhov PA, Rybalova TV, Gatilov YV, Tkachev AV. Syntheses and crystal structure of bridged Os3-clusters with chiral 3-carane-type ligands Journal of Organometallic Chemistry. 604: 1-6.  0.48
1999 Rukavishnikov AV, Phadke A, Lee MD, LaMunyon DH, Petukhov PA, Keana JFW. A tower-shaped prototypic molecule designed as an atomically sharp tip for AFM applications Tetrahedron Letters. 40: 6353-6356. DOI: 10.1016/S0040-4039(99)01207-1  0.48
1999 Maksakov VA, Kirin VP, Virovets AV, Petukhov PA, Tkachev AV. Transformation of diaminocarane on a triosmium cluster. Absolute configuration of a cluster with a bridging imidyl ligand Mendeleev Communications. 9.  0.48
1997 Petukhov PA, Tkachev AV. Synthesis of chiral hexahydrophenazines by treatment of dimeric nitrosochlorides with 1,2-diaminoarenes Tetrahedron. 53: 9761-9768. DOI: 10.1016/S0040-4020(97)00623-6  0.48
1997 Petukhov PA, Tkachev AV. Sodium borohydride in an acetonitrile medium: An efficient reagent for reductive Beckmann type fragmentation of α-amino oximes Tetrahedron. 53: 2535-2550. DOI: 10.1016/S0040-4020(96)01142-8  0.48
1997 Petukhov PA, Denisov AY, Tkachev AV. Rearrangement of α-hydroxylamino oximes to cyclic amidoximes by the action of sodium borohydride Tetrahedron. 53: 2527-2534. DOI: 10.1016/S0040-4020(96)01141-6  0.48
1996 Petukhov PA. Synthesis of monoterpenic α-amino ketones Mendeleev Communications. 6: 64-66.  0.48
1995 Tkachev AV, Petukhov PA, Konchenko SN, Korenev SV, Fedotov MA, Gatilov YV, Rybalova TV, Kholdeeva OA. Optically active ZnII and PtII complexes of the 3-carene type α-amino oxime Tetrahedron: Asymmetry. 6: 115-122. DOI: 10.1016/0957-4166(94)00366-J  0.48
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