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Leemor Joshua-Tor - Publications

Affiliations: 
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
 Howard Hughes Medical Institute, Chevy Chase, MD, United States 
Area:
Structural biology, Nucleic acid regulation, RNAi, Molecular recognition, X-ray crystallography
Website:
http://joshua-torlab.labsites.cshl.edu/
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74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Qian Z, Song D, Ipsaro JJ, Bautista C, Joshua-Tor L, Yeh JT, Tonks NK. Manipulating PTPRD function with ectodomain antibodies. Genes & Development. PMID 37669874 DOI: 10.1101/gad.350713.123  0.716
2023 Lee SC, Adams DW, Ipsaro JJ, Cahn J, Lynn J, Kim HS, Berube B, Major V, Calarco JP, LeBlanc C, Bhattacharjee S, Ramu U, Grimanelli D, Jacob Y, Voigt P, ... Joshua-Tor L, et al. Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation. Cell. PMID 37643610 DOI: 10.1016/j.cell.2023.08.001  0.723
2023 Lee SC, Adams DW, Ipsaro JJ, Cahn J, Lynn J, Kim HS, Berube B, Major V, Calarco JP, LeBlanc C, Bhattacharjee S, Ramu U, Grimanelli D, Jacob Y, Voigt P, ... Joshua-Tor L, et al. Chromatin remodeling of histone H3 variants underlies epigenetic inheritance of DNA methylation. Biorxiv : the Preprint Server For Biology. PMID 37503143 DOI: 10.1101/2023.07.11.548598  0.731
2023 Gao Y, He XY, Wu XS, Huang YH, Toneyan S, Ha T, Ipsaro JJ, Koo PK, Joshua-Tor L, Bailey KM, Egeblad M, Vakoc CR. ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation. Nature Cell Biology. PMID 36658219 DOI: 10.1038/s41556-022-01060-1  0.733
2022 Wu XS, He XY, Ipsaro JJ, Huang YH, Preall JB, Ng D, Shue YT, Sage J, Egeblad M, Joshua-Tor L, Vakoc CR. OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Nature. PMID 35576971 DOI: 10.1038/s41586-022-04842-7  0.703
2022 Ipsaro JJ, Joshua-Tor L. Developmental roles and molecular mechanisms of Asterix/GTSF1. Wiley Interdisciplinary Reviews. Rna. e1716. PMID 35108755 DOI: 10.1002/wrna.1716  0.731
2021 Ipsaro JJ, O'Brien PA, Bhattacharya S, Palmer AG, Joshua-Tor L. Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons. Cell Reports. 34: 108914. PMID 33789107 DOI: 10.1016/j.celrep.2021.108914  0.758
2020 Jaremko MJ, On KF, Thomas DR, Stillman B, Joshua-Tor L. The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife. 9. PMID 32808929 DOI: 10.7554/Elife.58622  0.4
2020 Bibel B, Elkayam E, Joshua-Tor L. Mechanisms of Phosphorylation‐Mediated Regulation of the RNAi Effector Protein Argonaute 2 The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03259  0.315
2019 Stein CB, Genzor P, Mitra S, Elchert AR, Ipsaro JJ, Benner L, Sobti S, Su Y, Hammell M, Joshua-Tor L, Haase AD. Decoding the 5' nucleotide bias of PIWI-interacting RNAs. Nature Communications. 10: 828. PMID 30783109 DOI: 10.1038/S41467-019-08803-Z  0.737
2019 Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AKL. ELTA: Enzymatic Labeling of Terminal ADP-Ribose. Molecular Cell. PMID 30712989 DOI: 10.1016/J.Molcel.2018.12.022  0.359
2018 On KF, Jaremko M, Stillman B, Joshua-Tor L. A structural view of the initiators for chromosome replication. Current Opinion in Structural Biology. 53: 131-139. PMID 30218786 DOI: 10.1016/J.Sbi.2018.08.003  0.354
2018 Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, et al. FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Molecular Cell. 69: 787-801.e8. PMID 29499134 DOI: 10.1016/J.Molcel.2018.02.001  0.376
2018 Li J, Wu C, Wang W, He Y, Elkayam E, Joshua-Tor L, Hammond PT. Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432194 DOI: 10.1073/Pnas.1719565115  0.37
2017 Elkayam E, Faehnle CR, Morales M, Sun J, Li H, Joshua-Tor L. Multivalent Recruitment of Human Argonaute by GW182. Molecular Cell. PMID 28781232 DOI: 10.1016/J.Molcel.2017.07.007  0.342
2017 Faehnle CR, Walleshauser J, Joshua-Tor L. Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. Nature Structural & Molecular Biology. PMID 28671666 DOI: 10.1038/Nsmb.3428  0.357
2017 Ipsaro JJ, Shen C, Arai E, Xu Y, Kinney JB, Joshua-Tor L, Vakoc CR, Shi J. Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis. Plos One. 12: e0172177. PMID 28231254 DOI: 10.1371/Journal.Pone.0172177  0.711
2017 Tocilj A, On KF, Yuan Z, Sun J, Elkayam E, Li H, Stillman B, Joshua-Tor L. Structure of the active form of human Origin Recognition Complex and its ATPase motor module. Elife. 6. PMID 28112645 DOI: 10.7554/Elife.20818  0.38
2016 Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L. siRNA carrying an (E)-vinylphosphonate moiety at the 5' end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2. Nucleic Acids Research. PMID 27903888 DOI: 10.1093/Nar/Gkw1171  0.408
2015 Shen C, Ipsaro JJ, Shi J, Milazzo JP, Wang E, Roe JS, Suzuki Y, Pappin DJ, Joshua-Tor L, Vakoc CR. NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. Molecular Cell. PMID 26626481 DOI: 10.1016/J.Molcel.2015.10.033  0.746
2015 Kuhn CD, Wilusz JE, Zheng Y, Beal PA, Joshua-Tor L. On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme. Cell. 160: 644-58. PMID 25640237 DOI: 10.1016/J.Cell.2015.01.005  0.344
2015 Ipsaro JJ, Joshua-Tor L. From guide to target: molecular insights into eukaryotic RNA-interference machinery. Nature Structural & Molecular Biology. 22: 20-8. PMID 25565029 DOI: 10.1038/Nsmb.2931  0.739
2014 Faehnle CR, Walleshauser J, Joshua-Tor L. Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway. Nature. 514: 252-6. PMID 25119025 DOI: 10.1038/Nature13553  0.416
2014 Lee SJ, Syed S, Enemark EJ, Schuck S, Stenlund A, Ha T, Joshua-Tor L. Dynamic look at DNA unwinding by a replicative helicase. Proceedings of the National Academy of Sciences of the United States of America. 111: E827-35. PMID 24550505 DOI: 10.1073/Pnas.1322254111  0.365
2014 Kuscu C, Zaratiegui M, Kim HS, Wah DA, Martienssen RA, Schalch T, Joshua-Tor L. CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing. Proceedings of the National Academy of Sciences of the United States of America. 111: 1795-800. PMID 24449894 DOI: 10.1073/Pnas.1313096111  0.739
2014 Kuscu C, Zaratiegui M, Kim HS, Wah DA, Martienssen RA, Schalch T, Joshua-Tor L. Erratum: CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (1795-1800) DOI: 10.1073/pnas.1313096111) Proceedings of the National Academy of Sciences of the United States of America. 111: 14307-14308. DOI: 10.1073/Pnas.1417135111  0.655
2013 Faehnle CR, Elkayam E, Haase AD, Hannon GJ, Joshua-Tor L. The Making of a Slicer: Activation of Human Argonaute-1 Cell Reports. 3: 1901-1909. PMID 23746446 DOI: 10.1016/J.Celrep.2013.05.033  0.379
2013 Kuhn CD, Joshua-Tor L. Eukaryotic Argonautes come into focus. Trends in Biochemical Sciences. 38: 263-71. PMID 23541793 DOI: 10.1016/J.Tibs.2013.02.008  0.377
2013 Paul S, Kuo A, Schalch T, Vogel H, Joshua-Tor L, McCombie WR, Gozani O, Hammell M, Mills AA. Chd5 requires PHD-mediated histone 3 binding for tumor suppression. Cell Reports. 3: 92-102. PMID 23318260 DOI: 10.1016/J.Celrep.2012.12.009  0.395
2012 Wilusz JE, JnBaptiste CK, Lu LY, Kuhn CD, Joshua-Tor L, Sharp PA. A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails. Genes & Development. 26: 2392-407. PMID 23073843 DOI: 10.1101/Gad.204438.112  0.395
2012 Ipsaro JJ, Haase AD, Knott SR, Joshua-Tor L, Hannon GJ. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis Nature. 491: 279-282. PMID 23064227 DOI: 10.1038/Nature11502  0.748
2012 Elkayam E, Kuhn CD, Tocilj A, Haase AD, Greene EM, Hannon GJ, Joshua-Tor L. The structure of human argonaute-2 in complex with miR-20a. Cell. 150: 100-10. PMID 22682761 DOI: 10.1016/J.Cell.2012.05.017  0.4
2012 Lavy T, Kumar PR, He H, Joshua-Tor L. The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation. Genes & Development. 26: 294-303. PMID 22302941 DOI: 10.1101/Gad.182691.111  0.407
2011 Schalch T, Job G, Shanker S, Partridge JF, Joshua-Tor L. The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Nature Structural & Molecular Biology. 18: 1351-7. PMID 22081013 DOI: 10.1038/Nsmb.2151  0.43
2011 Joshua-Tor L, Hannon GJ. Ancestral roles of small RNAs: an Ago-centric perspective. Cold Spring Harbor Perspectives in Biology. 3: a003772. PMID 20810548 DOI: 10.1101/Cshperspect.A003772  0.401
2009 Schalch T, Job G, Noffsinger VJ, Shanker S, Kuscu C, Joshua-Tor L, Partridge JF. High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin. Molecular Cell. 34: 36-46. PMID 19362535 DOI: 10.1016/J.Molcel.2009.02.024  0.711
2009 Kettner-Buhrow D, Guenther B, Kaelble S, Joshua-Tor L, Kracht M. Measurement of in vivo RISC activity using an in vitro non-radioactive RISC assay Naunyn-Schmiedebergs Archives of Pharmacology. 379. PMID 19229520 DOI: 10.1007/S00210-009-0404-1  0.376
2008 Enemark EJ, Joshua-Tor L. On helicases and other motor proteins. Current Opinion in Structural Biology. 18: 243-57. PMID 18329872 DOI: 10.1016/J.Sbi.2008.01.007  0.363
2008 Kumar PR, Yu Y, Sternglanz R, Johnston SA, Joshua-Tor L. NADP regulates the yeast GAL induction system. Science (New York, N.Y.). 319: 1090-2. PMID 18292341 DOI: 10.1126/Science.1151903  0.42
2007 Faehnle CR, Joshua-Tor L. Argonautes confront new small RNAs. Current Opinion in Chemical Biology. 11: 569-77. PMID 17928262 DOI: 10.1016/J.Cbpa.2007.08.032  0.394
2007 Tolia NH, Joshua-Tor L. Slicer and the argonautes. Nature Chemical Biology. 3: 36-43. PMID 17173028 DOI: 10.1038/Nchembio848  0.362
2007 O'Farrell PA, Joshua-Tor L. Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure. The Biochemical Journal. 401: 421-8. PMID 17007609 DOI: 10.1042/Bj20060641  0.318
2006 Yigit E, Batista PJ, Bei Y, Pang KM, Chen CC, Tolia NH, Joshua-Tor L, Mitani S, Simard MJ, Mello CC. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell. 127: 747-57. PMID 17110334 DOI: 10.1016/J.Cell.2006.09.033  0.373
2006 Irvine DV, Zaratiegui M, Tolia NH, Goto DB, Chitwood DH, Vaughn MW, Joshua-Tor L, Martienssen RA. Argonaute slicing is required for heterochromatic silencing and spreading. Science (New York, N.Y.). 313: 1134-7. PMID 16931764 DOI: 10.1126/Science.1128813  0.406
2006 Enemark EJ, Joshua-Tor L. Mechanism of DNA translocation in a replicative hexameric helicase. Nature. 442: 270-5. PMID 16855583 DOI: 10.1038/Nature04943  0.369
2006 Song JJ, Joshua-Tor L. Argonaute and RNA--getting into the groove. Current Opinion in Structural Biology. 16: 5-11. PMID 16434185 DOI: 10.1016/J.Sbi.2006.01.010  0.384
2006 Tolia NH, Joshua-Tor L. Strategies for protein coexpression in Escherichia coli. Nature Methods. 3: 55-64. PMID 16369554 DOI: 10.1038/Nmeth0106-55  0.313
2005 Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L. Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum. Cell. 122: 183-93. PMID 16051144 DOI: 10.1016/J.Cell.2005.05.033  0.324
2005 Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L. Purified Argonaute2 and an siRNA form recombinant human RISC. Nature Structural & Molecular Biology. 12: 340-9. PMID 15800637 DOI: 10.1038/Nsmb918  0.392
2004 Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ. Argonaute2 is the catalytic engine of mammalian RNAi. Science (New York, N.Y.). 305: 1437-41. PMID 15284456 DOI: 10.1126/Science.1102513  0.398
2004 Song JJ, Smith SK, Hannon GJ, Joshua-Tor L. Crystal structure of Argonaute and its implications for RISC slicer activity. Science (New York, N.Y.). 305: 1434-7. PMID 15284453 DOI: 10.1126/Science.1102514  0.432
2004 Auster AS, Joshua-Tor L. The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA binding. The Journal of Biological Chemistry. 279: 3733-42. PMID 14593106 DOI: 10.1074/Jbc.M311681200  0.741
2003 Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L. The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nature Structural Biology. 10: 1026-32. PMID 14625589 DOI: 10.1038/Nsb1016  0.422
2002 Van Aalten DMF, Crielaard W, Hellingwerf KJ, Joshua-Tor L. Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 Å resolution Acta Crystallographica Section D: Biological Crystallography. 58: 585-590. PMID 11914481 DOI: 10.1107/S0907444902001257  0.325
2002 Messick TE, Chmiel NH, Golinelli MP, Langer MR, Joshua-Tor L, David SS. Noncysteinyl coordination to the [4Fe-4S]2+ cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster. Biochemistry. 41: 3931-42. PMID 11900536 DOI: 10.1021/Bi012035X  0.687
2002 Enemark EJ, Stenlund A, Joshua-Tor L. Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex. The Embo Journal. 21: 1487-96. PMID 11889054 DOI: 10.1093/Emboj/21.6.1487  0.397
2002 Van Aalten DMF, Haker A, Hendriks J, Hellingwerf KJ, Joshua-Tor L, Crielaard W. Engineering photocycle dynamics: Crystal structures and kinetics of three photoactive yellow protein hinge-bending mutants Journal of Biological Chemistry. 277: 6463-6468. PMID 11714713 DOI: 10.1074/Jbc.M109313200  0.321
2001 Russell SJ, Gonzalez F, Joshua-Tor L, Johnston SA. Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases. Chemistry & Biology. 8: 941-50. PMID 11590019 DOI: 10.1016/S1074-5521(01)00060-6  0.304
2000 Van Aalten DMF, Chong CR, Joshua-Tor L. Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 Å - Inhibitor-induced conformational changes Biochemistry. 39: 10082-10089. PMID 10955996 DOI: 10.1021/Bi000952H  0.307
2000 Enemark EJ, Chen G, Vaughn DE, Stenlund A, Joshua-Tor L. Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus Molecular Cell. 6: 149-158. PMID 10949036 DOI: 10.1016/S1097-2765(05)00016-X  0.374
2000 Van Aalten DMF, Crielaard W, Hellingwerf KJ, Joshua-Tor L. Conformational substates in different crystal forms of the photoactive yellow protein - Correlation with theoretical and experimental flexibility Protein Science. 9: 64-72. PMID 10739248 DOI: 10.1110/Ps.9.1.64  0.303
1999 Vaughn DE, Rodriguez J, Lazebnik Y, Joshua-Tor L. Crystal structure of Apaf-1 caspase recruitment domain: An α-helical Greek key fold for apoptotic signaling Journal of Molecular Biology. 293: 439-447. PMID 10543941 DOI: 10.1006/Jmbi.1999.3177  0.332
1999 van Aalten DM, Erlanson DA, Verdine GL, Joshua-Tor L. A structural snapshot of base-pair opening in DNA. Proceedings of the National Academy of Sciences of the United States of America. 96: 11809-14. PMID 10518532 DOI: 10.1073/Pnas.96.21.11809  0.363
1998 Schlessman JL, Woo D, Joshua-Tor L, Howard JB, Rees DC. Conformational variability in structures of the nitrogenase iron proteins from Azotobacter vinelandii and Clostridium pasteurianum. Journal of Molecular Biology. 280: 669-85. PMID 9677296 DOI: 10.1006/Jmbi.1998.1898  0.63
1998 van Aalten DM, Grotewold E, Joshua-Tor L. Essential dynamics from NMR clusters: dynamic properties of the Myb DNA-binding domain and a hinge-bending enhancing variant. Methods (San Diego, Calif.). 14: 318-28. PMID 9571087 DOI: 10.1006/Meth.1998.0587  0.315
1998 Zheng W, Johnston SA, Joshua-Tor L. The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase Cell. 93: 103-109. PMID 9546396 DOI: 10.1016/S0092-8674(00)81150-2  0.303
1995 Joshua-Tor L, Xu HE, Johnston SA, Rees DC. Crystal structure of a conserved protease that binds DNA: The bleomycin hydrolase, Gal6 Science. 269: 945-950. PMID 7638617 DOI: 10.1126/Science.7638617  0.569
1993 Joshua-Tor L, Sussman JL. The coming of age of DMA crystallography Current Opinion in Structural Biology. 3: 323-335. DOI: 10.1016/S0959-440X(05)80102-2  0.525
1992 Joshua-Tor L, Frolow F, Appella E, Hope H, Rabinovich D, Sussman JL. Three-dimensional structures of bulge-containing DNA fragments. Journal of Molecular Biology. 225: 397-431. PMID 1593627 DOI: 10.1016/0022-2836(92)90929-E  0.552
1992 Berman HM, Sussman JL, Joshua-Tor L, Revich GG, Ripley LS. A structural model for sequence-specific proflavin-dna interactions during in vitro frameshift mutagenesis Journal of Biomolecular Structure and Dynamics. 10: 317-331. PMID 1466812 DOI: 10.1080/07391102.1992.10508650  0.544
1992 Blake PR, Day MW, Hsu BT, Joshua-Tor L, Park JB, Hare DR, Adams MW, Rees DC, Summers MF. Comparison of the X-ray structure of native rubredoxin from Pyrococcus furiosus with the NMR structure of the zinc-substituted protein. Protein Science : a Publication of the Protein Society. 1: 1522-5. PMID 1303770 DOI: 10.1002/Pro.5560011113  0.488
1992 Day MW, Hsu BT, Joshua-Tor L, Park JB, Zhou ZH, Adams MWW, Rees DC. X-ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium Pyrococcus furiosus Protein Science. 1: 1494-1507. PMID 1303768 DOI: 10.1002/Pro.5560011111  0.477
1991 David SS, Joshua-Tor L, Rees DC, Barton JK. NMR and X-ray crystallographic studies of the binding of chiral metal complexes to oligonucleotides Journal of Inorganic Biochemistry. 43: 433. DOI: 10.1016/0162-0134(91)84415-6  0.476
1988 Joshua-Tor L, Rabinovich D, Hope H, Frolow F, Appella E, Sussman JL. The three-dimensional structure of a DNA duplex containing looped-out bases. Nature. 334: 82-4. PMID 3386751 DOI: 10.1038/334082A0  0.548
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