Peter A. Crooks - Publications

Affiliations: 
Chemistry University of Kentucky, Lexington, KY 
Area:
General Chemistry, Pharmacology

329 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Balasubramaniam M, Ayyadevara S, Ganne A, Kakraba S, Penthala NR, Du X, Crooks PA, Griffin ST, Shmookler Reis RJ. Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases. Iscience. 20: 248-264. PMID 31593839 DOI: 10.1016/j.isci.2019.09.026  0.76
2019 Lee NR, Zheng G, Leggas M, Janganati V, Nickell JR, Crooks PA, Bardo MT, Dwoskin L. GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine. The Journal of Pharmacology and Experimental Therapeutics. PMID 31413138 DOI: 10.1124/jpet.119.258699  0.44
2019 Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of human DNA polymerases eta and kappa by indole-derived molecules occurs through distinct mechanisms. Acs Chemical Biology. PMID 31082191 DOI: 10.1021/acschembio.9b00304  0.76
2019 Ford BM, Cabanlong CV, Tai S, Franks LN, Penthala NR, Crooks PA, Prather PL, Fantegrossi WE. Reduced tolerance and asymmetrical cross-tolerance to effects of indole quinuclidinone analogue PNR-4-20, a G protein biased CB1R agonist in mice: comparisons with Δ9-THC and JWH-018. The Journal of Pharmacology and Experimental Therapeutics. PMID 30833484 DOI: 10.1124/jpet.118.252965  0.76
2019 Bommagani S, Penthala NR, Balasubramaniam M, Kuravi S, Caldas-Lopes E, Guzman ML, Balusu R, Crooks PA. A novel tetrazole analogue of resveratrol is a potent anticancer agent. Bioorganic & Medicinal Chemistry Letters. 29: 172-178. PMID 30528695 DOI: 10.1016/j.bmcl.2018.12.006  0.76
2018 Marecki JC, Aarattuthodiyil S, Byrd AK, Penthala NR, Crooks PA, Raney KD. N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3. Bioorganic & Medicinal Chemistry Letters. PMID 30578035 DOI: 10.1016/j.bmcl.2018.12.026  0.76
2018 Bommagani S, Penthala NR, Parkin S, Crooks PA. Crystal structure of 13-()-(2-amino-benzyl-idene)parthenolide. Acta Crystallographica. Section E, Crystallographic Communications. 74: 1543-1546. PMID 30443377 DOI: 10.1107/S2056989018013622  0.76
2018 Maggio SE, Saunders MA, Nixon K, Prendergast MA, Zheng G, Crooks PA, Dwoskin LP, Bell RL, Bardo MT. An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic α6β2* antagonist r-bPiDI. Drug and Alcohol Dependence. 193: 154-161. PMID 30384323 DOI: 10.1016/j.drugalcdep.2018.09.008  0.4
2018 Lamture G, Crooks PA, Borrelli MJ. Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells. Drug Development Research. 79: 287-294. PMID 30295945 DOI: 10.1002/ddr.21441  0.76
2018 Janganati V, Ponder J, Balasubramaniam M, Bhat-Nakshatri P, Bar EE, Nakshatri H, Jordan CT, Crooks PA. MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells. European Journal of Medicinal Chemistry. 157: 562-581. PMID 30121494 DOI: 10.1016/j.ejmech.2018.08.010  0.44
2018 Dachavaram SS, Penthala NR, Calahan JL, Munson EJ, Crooks PA. Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers. Organic & Biomolecular Chemistry. 16: 6057-6062. PMID 30090907 DOI: 10.1039/c8ob01438h  0.76
2018 Flores-Lopez G, Moreno-Lorenzana D, Ayala-Sanchez M, Aviles-Vazquez S, Torres-Martinez H, Crooks PA, Guzman ML, Mayani H, Chávez-González A. Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species. Journal of Cellular and Molecular Medicine. PMID 30079458 DOI: 10.1111/jcmm.13755  0.56
2018 Yadlapalli JSK, Bommagani SB, Mahelona RD, Wan A, Gannon BM, Penthala NR, Dobretsov M, Crooks PA, Fantegrossi WE. Evaluation of morphine-like effects of the mixed mu/delta agonist morphine-6--sulfate in rats: Drug discrimination and physical dependence. Pharmacology Research & Perspectives. 6: e00403. PMID 29930811 DOI: 10.1002/prp2.403  0.76
2018 Yadlapalli JSK, Dogra N, Walbaum AW, Prather PL, Crooks PA, Dobretsov M. Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome? Neuroscience Letters. 673: 24-27. PMID 29490230 DOI: 10.1016/j.neulet.2018.02.054  0.48
2018 Lee NR, Zheng G, Crooks PA, Bardo MT, Dwoskin LP. New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders. The Aaps Journal. 20: 29. PMID 29427069 DOI: 10.1208/s12248-018-0192-y  0.4
2018 Zafar MK, Maddukuri L, Ketkar A, Penthala N, Reed MR, Eddy SD, Crooks PA, Eoff RL. A small-molecule inhibitor of human DNA polymerase eta potentiates the effects of cisplatin in tumor cells. Biochemistry. PMID 29345908 DOI: 10.1021/acs.biochem.7b01176  0.76
2018 Yadlapalli JSK, Dogra N, Walbaum AW, Prather PL, Crooks PA, Dobretsov M. Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy. Life Sciences. 192: 151-159. PMID 29191644 DOI: 10.1016/j.lfs.2017.11.042  0.48
2017 Hankosky ER, Joolakanti SR, Nickell JR, Janganati V, Dwoskin LP, Crooks PA. Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 29153425 DOI: 10.1016/j.bmcl.2017.10.039  0.44
2017 Kangiser MM, Dwoskin LP, Zheng G, Crooks PA, Stairs DJ. Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats. Behavioural Pharmacology. PMID 28863003 DOI: 10.1097/FBP.0000000000000340  0.4
2017 Ford BM, Franks LN, Tai S, Fantegrossi WE, Stahl EL, Berquist MD, Cabanlong CV, Wilson CD, Penthala NR, Crooks PA, Prather PL. Characterization of Structurally Novel G Protein Biased CB1 Agonists: Implications for Drug Development. Pharmacological Research. PMID 28838808 DOI: 10.1016/j.phrs.2017.08.008  0.76
2017 Walbaum A, Fifer EK, Parkin S, Crooks PA. Crystal structure of 4,4'-bis-[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta Crystallographica. Section E, Crystallographic Communications. 73: 864-866. PMID 28638646 DOI: 10.1107/S2056989017007277  0.6
2017 Janganati V, Ponder J, Thakkar S, Jordan CT, Crooks PA. Succinamide derivatives of melampomagnolide B and their anti-cancer activities. Bioorganic & Medicinal Chemistry. PMID 28545815 DOI: 10.1016/j.bmc.2017.05.008  0.76
2017 Bommagani S, Ponder J, Penthala NR, Janganati V, Jordan CT, Borrelli MJ, Crooks PA. Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells. European Journal of Medicinal Chemistry. 136: 393-405. PMID 28525840 DOI: 10.1016/j.ejmech.2017.05.031  0.76
2017 Yadlapalli JSK, Dogra N, Walbaum AW, Wessinger WD, Prather PL, Crooks PA, Dobretsov M. Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats. Anesthesia and Analgesia. PMID 28489639 DOI: 10.1213/ANE.0000000000002006  0.48
2017 Madadi NR, Penthala NR, Ketkar A, Eoff RL, Trujullo-Alonso V, Guzman ML, Crooks PA. Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer agents. Anti-Cancer Agents in Medicinal Chemistry. PMID 28403783 DOI: 10.2174/1871521409666170412115703  0.96
2017 Yadlapalli JS, Albayati ZA, Penthala NR, Hendrickson HP, Crooks PA. Stability studies of potent opioid analgesic, morphine-6-O-sulfate in various buffers and biological matrices by HPLC-DAD analysis. Biomedical Chromatography : Bmc. PMID 28205234 DOI: 10.1002/bmc.3957  0.76
2016 Albayati ZA, Janganati V, Chen Z, Ponder J, Breen PJ, Jordan CT, Crooks PA. Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia. Bioorganic & Medicinal Chemistry. PMID 28049618 DOI: 10.1016/j.bmc.2016.12.036  0.44
2016 Nickell JR, Siripurapu KB, Horton DB, Zheng G, Crooks PA, Dwoskin LP. GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2. European Journal of Pharmacology. 795: 143-149. PMID 27986625 DOI: 10.1016/j.ejphar.2016.12.016  0.4
2016 Penthala NR, Janganati V, Alpe TL, Apana SM, Berridge MS, Crooks PA, Borrelli MJ. N-[(11)CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat. Bioorganic & Medicinal Chemistry Letters. PMID 27866815 DOI: 10.1016/j.bmcl.2016.11.015  0.76
2016 Yadlapalli JS, Ford BM, Ketkar A, Wan A, Penthala NR, Eoff RL, Prather PL, Dobretsov M, Crooks PA. Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors. Pharmacological Research. PMID 27637375 DOI: 10.1016/j.phrs.2016.09.012  0.76
2016 Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, et al. Rational Design of a Parthenolide-based Drug Regimen that Selectively Eradicates Acute Myelogenous Leukemia Stem Cells. The Journal of Biological Chemistry. PMID 27573247 DOI: 10.1074/jbc.M116.750653  0.96
2016 Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27524311 DOI: 10.1016/j.bmcl.2016.08.001  0.96
2016 Han YS, Penthala NR, Oliveira M, Mesplède T, Xu H, Quan Y, Crooks PA, Wainberg MA. Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay. Journal of Medical Virology. PMID 27509184 DOI: 10.1002/jmv.24660  0.76
2016 Penthala NR, Yadlapalli JK, Parkin S, Crooks PA. Crystal structures of (Z)-5-[2-(benzo[b]thio-phen-2-yl)-1-(3,5-di-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole and (Z)-5-[2-(benzo[b]thio-phen-3-yl)-1-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole. Acta Crystallographica. Section E, Crystallographic Communications. 72: 652-5. PMID 27308011 DOI: 10.1107/S2056989016005600  0.76
2016 Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. 1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27212067 DOI: 10.1016/j.bmcl.2016.05.025  0.96
2016 Joolakanti SR, Nickell JR, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27080180 DOI: 10.1016/j.bmcl.2016.03.119  0.96
2016 Madadi NR, Ketkar A, Penthala NR, Bostian AC, Eoff RL, Crooks PA. Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells. Bioorganic & Medicinal Chemistry Letters. PMID 27017113 DOI: 10.1016/j.bmcl.2016.03.068  0.96
2015 Penthala NR, Madhukuri L, Thakkar S, Madadi NR, Lamture G, Eoff RL, Crooks PA. Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents. Medchemcomm. 6: 1535-1543. PMID 27066215 DOI: 10.1039/C5MD00219B  0.96
2015 Bommagani S, Penthala NR, Parkin S, Crooks PA. Crystal structure of (E)-13-(pyrimidin-5-yl)parthenolide. Acta Crystallographica. Section E, Crystallographic Communications. 71: 1536-8. PMID 26870423 DOI: 10.1107/S2056989015021507  0.76
2015 Albayati ZA, Sunkara M, Schmidt-Malan SM, Karau MJ, Morris AJ, Steckelberg JM, Patel R, Breen PJ, Smeltzer MS, Taylor KG, Merten KE, Pierce WM, Crooks PA. USE OF A NOVEL BONE-TARGETING AGENT FOR THE ENHANCED DELIVERY OF VANCOMYCIN TO BONE. Antimicrobial Agents and Chemotherapy. PMID 26666918 DOI: 10.1128/AAC.01609-15  0.96
2015 Penthala NR, Ketkar A, Sekhar KR, Freeman ML, Eoff RL, Balusu R, Crooks PA. 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1). Bioorganic & Medicinal Chemistry. PMID 26602084 DOI: 10.1016/j.bmc.2015.10.019  0.96
2015 Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison crystal structure conformations of two structurally related biphenyl analogues: 4,4'-bis-[3-(pyrrolidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-{3-[(S)-2-methyl-pyrrolidin-1-yl]prop-1-yn-1-yl}-1,1'-biphen-yl. Acta Crystallographica. Section E, Crystallographic Communications. 71: 1147-50. PMID 26594393 DOI: 10.1107/S2056989015016163  0.96
2015 Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison of the crystal structures of 4,4'-bis-[3-(4-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-[3-(2,2,6,6-tetra-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta Crystallographica. Section E, Crystallographic Communications. 71: 1132-5. PMID 26594389 DOI: 10.1107/S2056989015015352  0.96
2015 Crooks PA, Janganati V, Ponder J, Jordan CT, Borrelli MJ, Penthala NR. Dimers of melampomagnolide B exhibit potent anticancer activity against hematological and solid tumor cells. Journal of Medicinal Chemistry. PMID 26540463 DOI: 10.1021/acs.jmedchem.5b01187  0.96
2015 Madadi NR, Penthala NR, Howk K, Ketkar A, Eoff RL, Borrelli MJ, Crooks PA. Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4. European Journal of Medicinal Chemistry. 103: 123-32. PMID 26352674 DOI: 10.1016/j.ejmech.2015.08.041  0.96
2015 Madadi NR, Zong H, Ketkar A, Zheng C, Penthala NR, Janganati V, Bommagani S, Eoff RL, Guzman ML, Crooks PA. Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin. Medchemcomm. 6: 788-794. PMID 26257861 DOI: 10.1039/C4MD00478G  0.96
2015 Beckmann JS, Meyer AC, Pivavarchyk M, Horton DB, Zheng G, Smith AM, Wooters TE, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement. Neurochemical Research. PMID 26227997 DOI: 10.1007/s11064-015-1680-4  0.96
2015 Penthala NR, Thakkar S, Crooks PA. Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 25: 2763-7. PMID 26022840 DOI: 10.1016/j.bmcl.2015.05.019  0.76
2015 Ding D, Nickell JR, Dwoskin LP, Crooks PA. Quinolyl analogues of norlobelane: Novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. 25: 2613-6. PMID 25991431 DOI: 10.1016/j.bmcl.2015.04.105  0.96
2015 Penthala NR, Crooks PA, Freeman ML, Sekhar KR. Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1. Bioorganic & Medicinal Chemistry. 23: 3681-6. PMID 25922180 DOI: 10.1016/j.bmc.2015.04.018  0.96
2015 Holt JC, Kewin K, Jordan PM, Cameron P, Klapczynski M, McIntosh JM, Crooks PA, Dwoskin LP, Lysakowski A. Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 3625-43. PMID 25716861 DOI: 10.1523/JNEUROSCI.3388-14.2015  0.96
2015 Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA. Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents. European Journal of Medicinal Chemistry. 92: 212-20. PMID 25557492 DOI: 10.1016/j.ejmech.2014.12.050  0.96
2015 Jang DS, Penthala NR, Apostolov EO, Wang X, Crooks PA, Basnakian AG. Novel cytoprotective inhibitors for apoptotic endonuclease G. Dna and Cell Biology. 34: 92-100. PMID 25401220 DOI: 10.1089/dna.2014.2530  0.76
2015 Jang DS, Penthala NR, Apostolov EO, Wang X, Fahmi T, Crooks PA, Basnakian AG. Novel high-throughput deoxyribonuclease 1 assay. Journal of Biomolecular Screening. 20: 202-11. PMID 25326282 DOI: 10.1177/1087057114555828  0.76
2015 Zheng G, Crooks PA. Synthesis of Lobeline, Lobelane and their Analogues. A Review Organic Preparations and Procedures International. 47: 317-337. DOI: 10.1080/00304948.2015.1066642  0.96
2015 Penthala NR, Thakkar S, Crooks PA. Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents Bioorganic and Medicinal Chemistry Letters. 25: 2763-2767. DOI: 10.1016/j.bmcl.2015.05.019  0.96
2015 Madadi NR, Crooks PA. Anticancer Evaluation of 3,4,5,4'-trans-tetramethoxystilbene (DMU-212) and Its Analogs Against an Extensive Panel of Human Tumor Cell Lines Letters in Drug Design and Discovery. 12: 521-528.  0.96
2014 Penthala NR, Madadi NR, Bommagani S, Parkin S, Crooks PA. Comparison of crystal structures of 4-(benzo[b]thio-phen-2-yl)-5-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole and 4-(benzo[b]thio-phen-2-yl)-2-methyl-5-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole. Acta Crystallographica. Section E, Structure Reports Online. 70: 392-5. PMID 25484755 DOI: 10.1107/S1600536814023095  0.96
2014 Madadi NR, Penthala NR, Bommagani S, Parkin S, Crooks PA. Crystal structure of 4,5-bis-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole methanol monosolvate. Acta Crystallographica. Section E, Structure Reports Online. 70: o1128-9. PMID 25484710 DOI: 10.1107/S1600536814020911  0.96
2014 Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA. Crystal structure of (E)-13-{4-[(Z)-2-cyano-2-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]phen-yl}parthenolide methanol hemisolvate. Acta Crystallographica. Section E, Structure Reports Online. 70: o1092-3. PMID 25484689 DOI: 10.1107/S1600536814019333  0.76
2014 Eldridge JA, Milewski M, Stinchcomb AL, Crooks PA. Synthesis and in vitro stability of amino acid prodrugs of 6-β-naltrexol for microneedle-enhanced transdermal delivery. Bioorganic & Medicinal Chemistry Letters. 24: 5212-5. PMID 25442314 DOI: 10.1016/j.bmcl.2014.09.072  0.96
2014 Penthala NR, Madadi NR, Janganati V, Crooks PA. L-Proline catalyzed one-step synthesis of 4,5-diaryl-2H-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide. Tetrahedron Letters. 55: 5562-5565. PMID 25267862 DOI: 10.1016/j.tetlet.2014.08.027  0.96
2014 Penthala NR, Bommagani S, Janganati V, MacNicol KB, Cragle CE, Madadi NR, Hardy LL, MacNicol AM, Crooks PA. Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression. European Journal of Medicinal Chemistry. 85: 517-25. PMID 25117652 DOI: 10.1016/j.ejmech.2014.08.022  0.96
2014 Sekhar KR, Benamar M, Venkateswaran A, Sasi S, Penthala NR, Crooks PA, Hann SR, Geng L, Balusu R, Abbas T, Freeman ML. Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization. International Journal of Radiation Oncology, Biology, Physics. 89: 1106-14. PMID 25035215 DOI: 10.1016/j.ijrobp.2014.04.012  0.96
2014 Janganati V, Penthala NR, Madadi NR, Chen Z, Crooks PA. Anti-cancer activity of carbamate derivatives of melampomagnolide B. Bioorganic & Medicinal Chemistry Letters. 24: 3499-502. PMID 24928404 DOI: 10.1016/j.bmcl.2014.05.059  0.96
2014 Franks LN, Ford BM, Madadi NR, Penthala NR, Crooks PA, Prather PL. Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs. European Journal of Pharmacology. 737: 140-8. PMID 24858620 DOI: 10.1016/j.ejphar.2014.05.007  0.96
2014 Janganati V, Penthala NR, Madadi NR, Parkin S, Crooks PA. Monosuccinate ester of melampomagnolide B. Acta Crystallographica. Section E, Structure Reports Online. 70: o372-3. PMID 24765054 DOI: 10.1107/S1600536814002815  0.96
2014 Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA. (E)-13-(2-Bromo-phen-yl)micheliolide. Acta Crystallographica. Section E, Structure Reports Online. 70: o251-2. PMID 24764970 DOI: 10.1107/S1600536814002177  0.76
2014 Janganati V, Penthala NR, Cragle CE, MacNicol AM, Crooks PA. Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation. Bioorganic & Medicinal Chemistry Letters. 24: 1963-7. PMID 24656611 DOI: 10.1016/j.bmcl.2014.02.067  0.76
2014 Greer AK, Madadi NR, Bratton SM, Eddy SD, Mazerska Z, Hendrickson HP, Crooks PA, Radominska-Pandya A. Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases. Chemical Research in Toxicology. 27: 536-45. PMID 24571610 DOI: 10.1021/tx400408x  0.96
2014 Crooks PA, Bardo MT, Dwoskin LP. Nicotinic receptor antagonists as treatments for nicotine abuse. Advances in Pharmacology (San Diego, Calif.). 69: 513-51. PMID 24484986 DOI: 10.1016/B978-0-12-420118-7.00013-5  0.96
2014 Nickell JR, Siripurapu KB, Vartak A, Crooks PA, Dwoskin LP. The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse. Advances in Pharmacology (San Diego, Calif.). 69: 71-106. PMID 24484975 DOI: 10.1016/B978-0-12-420118-7.00002-0  0.96
2014 Madadi NR, Penthala NR, Janganati V, Crooks PA. Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines. Bioorganic & Medicinal Chemistry Letters. 24: 601-3. PMID 24361000 DOI: 10.1016/j.bmcl.2013.12.013  0.96
2014 Venkateswaran A, Sekhar KR, Levic DS, Melville DB, Clark TA, Rybski WM, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML. The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. Cancer Research. 74: 38-43. PMID 24247717 DOI: 10.1158/0008-5472.CAN-13-1981  0.96
2014 Janardhan B, Rajitha B, Crooks PA. Poly(4-vinylpyridinium)hydrogen sulfate: An efficient heterogeneous catalyst for the one-pot synthesis of polyhydroquinolines via unsymmetrical Hantzsch reaction in aqueous medium Journal of Saudi Chemical Society. 18: 722-727. DOI: 10.1016/j.jscs.2014.01.009  0.96
2013 Ding D, Dwoskin LP, Crooks PA. Efficient synthesis of cis-2,6-di-(2- quinolylpiperidine). Tetrahedron Letters. 54: 5211-5213. PMID 24511163 DOI: 10.1016/j.tetlet.2013.07.067  0.96
2013 Bommagani S, Penthala NR, Janganati V, Parkin S, Crooks PA. 13-(N,N-Di-methyl-amino)-micheliolide 0.08-hydrate. Acta Crystallographica. Section E, Structure Reports Online. 69: o1789-90. PMID 24454230 DOI: 10.1107/S1600536813030304  0.76
2013 Janganati V, Penthala NR, Parkin S, Crooks PA. 13-(Imidazol-1-yl)-11,13-di-hydro-melampomagnolide B monohydrate. Acta Crystallographica. Section E, Structure Reports Online. 69: o1734-5. PMID 24454194 DOI: 10.1107/S1600536813029188  0.76
2013 Penthala NR, Janganati V, Parkin S, Varughese KI, Crooks PA. (E)-13-(4-Amino-phen-yl)parthenolide. Acta Crystallographica. Section E, Structure Reports Online. 69: o1709-10. PMID 24454134 DOI: 10.1107/S1600536813028730  0.76
2013 Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, ... ... Crooks PA, et al. Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells. The Journal of Biological Chemistry. 288: 33542-58. PMID 24089526 DOI: 10.1074/jbc.M113.511170  0.96
2013 Wilmouth CE, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. Oral administration of GZ-793A, a VMAT2 inhibitor, decreases methamphetamine self-administration in rats. Pharmacology, Biochemistry, and Behavior. 112: 29-33. PMID 24075974 DOI: 10.1016/j.pbb.2013.09.006  0.96
2013 Ding D, Nickell JR, Deaciuc AG, Penthala NR, Dwoskin LP, Crooks PA. Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake. Bioorganic & Medicinal Chemistry. 21: 6771-7. PMID 23993667 DOI: 10.1016/j.bmc.2013.08.001  0.96
2013 Penthala NR, Sonar VN, Horn J, Leggas M, Yadlapalli JS, Crooks PA. Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents. Medchemcomm. 4: 1073-1078. PMID 23956835 DOI: 10.1039/C3MD00130J  0.76
2013 Meyer AC, Neugebauer NM, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo. Journal of Neurochemistry. 127: 187-98. PMID 23875705 DOI: 10.1111/jnc.12373  0.96
2013 Horton DB, Nickell JR, Zheng G, Crooks PA, Dwoskin LP. GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine. Journal of Neurochemistry. 127: 177-86. PMID 23875622 DOI: 10.1111/jnc.12371  0.96
2013 Peng C, Kimbrell MR, Tian C, Pack TF, Crooks PA, Fifer EK, Papke RL. Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Molecular Pharmacology. 84: 459-75. PMID 23839567 DOI: 10.1124/mol.113.086462  0.96
2013 Coggins GE, Maddukuri L, Penthala NR, Hartman JH, Eddy S, Ketkar A, Crooks PA, Eoff RL. N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases. Acs Chemical Biology. 8: 1722-9. PMID 23679919 DOI: 10.1021/cb400305r  0.96
2013 Xu Y, Fang F, Miriyala S, Crooks PA, Oberley TD, Chaiswing L, Noel T, Holley AK, Zhao Y, Kiningham KK, Clair DK, Clair WH. KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells. Cancer Research. 73: 4406-17. PMID 23674500 DOI: 10.1158/0008-5472.CAN-12-4297  0.96
2013 Penthala NR, Ponugoti PR, Nickell JR, Deaciuc AG, Dwoskin LP, Crooks PA. Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2). Bioorganic & Medicinal Chemistry Letters. 23: 3342-5. PMID 23597792 DOI: 10.1016/j.bmcl.2013.03.092  0.96
2013 Yip-Schneider MT, Wu H, Stantz K, Agaram N, Crooks PA, Schmidt CM. Dimethylaminoparthenolide and gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. Bmc Cancer. 13: 194. PMID 23590467 DOI: 10.1186/1471-2407-13-194  0.96
2013 Zheng G, Horton DB, Penthala NR, Nickell JR, Culver JP, Deaciuc AG, Dwoskin LP, Crooks PA. Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse. Medchemcomm. 4: 564-568. PMID 23527317 DOI: 10.1039/C3MD20374C  0.96
2013 Madadi NR, Penthala NR, Brents LK, Ford BM, Prather PL, Crooks PA. Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors. Bioorganic & Medicinal Chemistry Letters. 23: 2019-21. PMID 23466226 DOI: 10.1016/j.bmcl.2013.02.025  0.96
2013 Ring JR, Zheng F, Haubner AJ, Littleton JM, Crooks PA. Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study. Bioorganic & Medicinal Chemistry. 21: 1764-74. PMID 23465801 DOI: 10.1016/j.bmc.2013.01.051  0.96
2013 Penthala NR, Crooks PA. rac-N-Benzyl-isatincreatinine (unknown solvate). Acta Crystallographica. Section E, Structure Reports Online. 69: o290-1. PMID 23424560 DOI: 10.1107/S1600536813000378  0.96
2013 Penthala NR, Crooks PA. rac-5-Bromo-N-benzyl-isatincreatinine ethanol monosolvate. Acta Crystallographica. Section E, Structure Reports Online. 69: o288-9. PMID 23424559 DOI: 10.1107/S160053681300038X  0.96
2013 Penthala NR, Ponugoti PR, Kasam V, Crooks PA. 5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties. Bioorganic & Medicinal Chemistry Letters. 23: 1442-6. PMID 23339966 DOI: 10.1016/j.bmcl.2012.12.053  0.76
2013 Venkateswaran A, Friedman DB, Walsh AJ, Skala MC, Sasi S, Rachakonda G, Crooks PA, Freeman ML, Sekhar KR. The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Investigational New Drugs. 31: 535-44. PMID 23054211 DOI: 10.1007/s10637-012-9884-9  0.96
2013 Yip-Schneider MT, Wu H, Hruban RH, Lowy AM, Crooks PA, Schmidt CM. Efficacy of dimethylaminoparthenolide and sulindac in combination with gemcitabine in a genetically engineered mouse model of pancreatic cancer. Pancreas. 42: 160-7. PMID 22699205 DOI: 10.1097/MPA.0b013e318254f455  0.96
2013 Kuarm BS, Crooks PA, Rajitha B. An expeditious synthesis of quinoxalines by using biodegradable cellulose sulfuric acid as a solid acid catalyst Green Chemistry Letters and Reviews. 6: 228-232. DOI: 10.1080/17518253.2012.752041  0.96
2012 Penthala NR, Ponugoti PR, Parkin S, Crooks PA. rac-(Z)-Methyl 1-benzyl-3-[(3-hy-droxy-quinuclidin-2-yl-idene)meth-yl]-1H-indole-6-carboxyl-ate. Acta Crystallographica. Section E, Structure Reports Online. 68: o3111. PMID 23284437 DOI: 10.1107/S1600536812040731  0.76
2012 Sonar VN, Parkin S, Crooks PA. Oxycodone N-oxide. Acta Crystallographica. Section C, Crystal Structure Communications. 68: o436-8. PMID 23124457 DOI: 10.1107/S0108270112040188  0.96
2012 Sonar VN, Parkin S, Crooks PA. The effect of hydrogen bonding on the conformations of 2-(1H-indol-3-yl)-2-oxoacetamide and 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide. Acta Crystallographica. Section C, Crystal Structure Communications. 68: o405-7. PMID 23007543 DOI: 10.1107/S0108270112038322  0.96
2012 Alvers KM, Beckmann JS, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats. Psychopharmacology. 224: 255-62. PMID 22638813 DOI: 10.1007/s00213-012-2748-3  0.96
2012 Holcomb BK, Yip-Schneider MT, Waters JA, Beane JD, Crooks PA, Schmidt CM. Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 16: 1333-40. PMID 22618517 DOI: 10.1007/s11605-012-1913-7  0.96
2012 Penthala NR, Parkin S, Crooks PA. (Z)-3-(1-Benzofuran-2-yl)-2-(3,4,5-tri-meth-oxy-phen-yl)acrylonitrile. Acta Crystallographica. Section E, Structure Reports Online. 68: o731. PMID 22412613 DOI: 10.1107/S1600536812005831  0.96
2012 Madadi NR, Parkin S, Crooks PA. (Z)-2-{2,4-Dimeth-oxy-6-[(E)-4-meth-oxy-styr-yl]benzyl-idene}quinuclidin-3-one. Acta Crystallographica. Section E, Structure Reports Online. 68: o730. PMID 22412612 DOI: 10.1107/S1600536812005843  0.96
2012 Penthala NR, Parkin S, Crooks PA. (Z)-3-(1H-Indol-3-yl)-2-(3,4,5-tri-methoxy-phen-yl)acrylonitrile. Acta Crystallographica. Section E, Structure Reports Online. 68: o729. PMID 22412611 DOI: 10.1107/S1600536812005855  0.96
2012 Beckmann JS, Denehy ED, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats. Psychopharmacology. 220: 395-403. PMID 21938414 DOI: 10.1007/s00213-011-2488-9  0.96
2012 Nalluri BN, Ramya Krishna M, Rao TP, Crooks PA. Effect of recrystallization on the pharmaceutical properties of valsartan for improved therapeutic efficacy Journal of Applied Pharmaceutical Science. 2: 126-132. DOI: 10.7324/JAPS.2012.21025  0.96
2012 Janardhan B, Rajitha B, Crooks PA. Poly(4-vinylpyridinium)hydrogen sulfate: An efficient and recyclable Bronsted acid catalyst for the synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones Journal of Saudi Chemical Society. DOI: 10.1016/j.jscs.2012.10.007  0.96
2011 Zhang Z, Dwoskin LP, Crooks PA. Expeditious synthesis of cis-1-methyl-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo-[3,2h]isoquinoline / [2,3-f]quinoline via azomethine ylide-alkene [3+2] cycloaddition. Tetrahedron Letters. 52: 2667-2669. PMID 23908558 DOI: 10.1016/j.tetlet.2011.03.065  0.96
2011 Holtman JR, Dwoskin LP, Dowell C, Wala EP, Zhang Z, Crooks PA, McIntosh JM. The novel small molecule α9α10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic. European Journal of Pharmacology. 670: 500-8. PMID 21944926 DOI: 10.1016/j.ejphar.2011.08.053  0.96
2011 Sekhar KR, Reddy YT, Reddy PN, Crooks PA, Venkateswaran A, McDonald WH, Geng L, Sasi S, Van Der Waal RP, Roti JL, Salleng KJ, Rachakonda G, Freeman ML. The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6490-9. PMID 21878537 DOI: 10.1158/1078-0432.CCR-11-1054  0.96
2011 Horton DB, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. The Journal of Pharmacology and Experimental Therapeutics. 339: 286-97. PMID 21778282 DOI: 10.1124/jpet.111.184770  0.96
2011 Nasim S, Guzman ML, Jordan CT, Crooks PA. Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture. Bioorganic & Medicinal Chemistry Letters. 21: 4879-83. PMID 21757349 DOI: 10.1016/j.bmcl.2011.06.027  0.96
2011 Biermann M, Hardcastle KI, Moskalev NV, Crooks PA. (S)-2-Amino-2-(2-chloro-phen-yl)cyclo-hexa-none. Acta Crystallographica. Section E, Structure Reports Online. 67: o936. PMID 21754205 DOI: 10.1107/S1600536811009950  0.96
2011 Ponugoti PR, Penthala NR, Dwoskin LP, Parkin S, Crooks PA. cis-1-Benzyl-pyrrolidine-2,5-dicarbonitrile. Acta Crystallographica. Section E, Structure Reports Online. 67: o747. PMID 21754044 DOI: 10.1107/S1600536811006258  0.96
2011 Ponugoti PR, Penthala NR, Dwoskin LP, Parkin S, Crooks PA. cis-2,5-Bis(2-fluoro-5-meth-oxy-pheneth-yl)pyrrolidinium formate. Acta Crystallographica. Section E, Structure Reports Online. 67: o737. PMID 21522476 DOI: 10.1107/S1600536811006143  0.96
2011 Hojahmat M, Zheng G, Siegler M, Parkin S, Biermann M, Crooks PA. (S)-1-(2-Chloro-phen-yl)-2-oxocyclo-hexan-1-aminium d-tartrate. Acta Crystallographica. Section E, Structure Reports Online. 67: o736. PMID 21522475 DOI: 10.1107/S1600536811006131  0.96
2011 Penthala NR, Reddy TR, Parkin S, Crooks PA. (2Z,3E)-2-{[1-(4-Chloro-benz-yl)-1H-indol-3-yl]methyl-idene}quinuclidin-3-one oxime. Acta Crystallographica. Section E, Structure Reports Online. 67: o735. PMID 21522474 DOI: 10.1107/S160053681100612X  0.76
2011 Zheng G, Zhang Z, Dowell C, Wala E, Dwoskin LP, Holtman JR, McIntosh JM, Crooks PA. Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain. Bioorganic & Medicinal Chemistry Letters. 21: 2476-9. PMID 21397497 DOI: 10.1016/j.bmcl.2011.02.043  0.96
2011 Pivavarchyk M, Smith AM, Zhang Z, Zhou D, Wang X, Toyooka N, Tsuneki H, Sasaoka T, McIntosh JM, Crooks PA, Dwoskin LP. Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release. European Journal of Pharmacology. 658: 132-9. PMID 21371454 DOI: 10.1016/j.ejphar.2011.02.018  0.96
2011 Penthala NR, Yerramreddy TR, Crooks PA. Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters. 21: 1411-3. PMID 21295476 DOI: 10.1016/j.bmcl.2011.01.020  0.96
2011 Nasim S, Pei S, Hagen FK, Jordan CT, Crooks PA. Melampomagnolide B: a new antileukemic sesquiterpene. Bioorganic & Medicinal Chemistry. 19: 1515-9. PMID 21273084 DOI: 10.1016/j.bmc.2010.12.045  0.96
2011 Al-Ghananeem AM, Malkawi AH, Crooks PA. Bioavailability of Δ⁹-tetrahydrocannabinol following intranasal administration of a mucoadhesive gel spray delivery system in conscious rabbits. Drug Development and Industrial Pharmacy. 37: 329-34. PMID 21244195 DOI: 10.3109/03639045.2010.513009  0.96
2011 Wooters TE, Smith AM, Pivavarchyk M, Siripurapu KB, McIntosh JM, Zhang Z, Crooks PA, Bardo MT, Dwoskin LP. bPiDI: a novel selective α6β2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse. British Journal of Pharmacology. 163: 346-57. PMID 21232049 DOI: 10.1111/j.1476-5381.2011.01220.x  0.96
2011 Horton DB, Siripurapu KB, Norrholm SD, Culver JP, Hojahmat M, Beckmann JS, Harrod SB, Deaciuc AG, Bardo MT, Crooks PA, Dwoskin LP. meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. The Journal of Pharmacology and Experimental Therapeutics. 336: 940-51. PMID 21177475 DOI: 10.1124/jpet.110.175117  0.96
2011 Zhang Z, Zheng G, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 21: 88-91. PMID 21147530 DOI: 10.1016/j.bmcl.2010.11.070  0.96
2011 Crooks PA, Zheng G, Vartak AP, Culver JP, Zheng F, Horton DB, Dwoskin LP. Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse. Current Topics in Medicinal Chemistry. 11: 1103-27. PMID 21050177 DOI: 10.2174/156802611795371332  0.96
2011 Nickell JR, Zheng G, Deaciuc AG, Crooks PA, Dwoskin LP. Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2. The Journal of Pharmacology and Experimental Therapeutics. 336: 724-33. PMID 20876747 DOI: 10.1124/jpet.110.172882  0.96
2010 Penthala NR, Eldridge J, Reddy TR, Parkin S, Crooks PA. (E,E)-1-Methyl-2,6-distyrylpyridinium iodide. Acta Crystallographica. Section E, Structure Reports Online. 66: o1793. PMID 21588003 DOI: 10.1107/S1600536810018519  0.76
2010 Madadi NR, Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-2-Amino-5-[2,4-dimeth-oxy-6-(4-methoxy-styr-yl)benzyl-idene]-1,3-thia-zol-4(5H)-one methanol solvate. Acta Crystallographica. Section E, Structure Reports Online. 66: o1792. PMID 21588002 DOI: 10.1107/S1600536810018520  0.96
2010 Nasim S, Vartak AP, Pierce WM, Taylor KG, Smith N, Crooks PA. 3-O-phosphate ester conjugates of 17-β-O-{1-[2-carboxy-(2-hydroxy-4-methoxy-3-carboxamido)anilido]ethyl}1,3,5(10)-estratriene as novel bone-targeting agents. Bioorganic & Medicinal Chemistry Letters. 20: 7450-3. PMID 21055931 DOI: 10.1016/j.bmcl.2010.10.023  0.96
2010 Venkateswaran A, Reddy YT, Sonar VN, Muthusamy V, Crooks PA, Freeman ML, Sekhar KR. Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives. Bioorganic & Medicinal Chemistry Letters. 20: 7323-6. PMID 21055930 DOI: 10.1016/j.bmcl.2010.10.060  0.96
2010 Hassane DC, Sen S, Minhajuddin M, Rossi RM, Corbett CA, Balys M, Wei L, Crooks PA, Guzman ML, Jordan CT. Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways. Blood. 116: 5983-90. PMID 20889920 DOI: 10.1182/blood-2010-04-278044  0.96
2010 Beckmann JS, Siripurapu KB, Nickell JR, Horton DB, Denehy ED, Vartak A, Crooks PA, Dwoskin LP, Bardo MT. The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats. The Journal of Pharmacology and Experimental Therapeutics. 335: 841-51. PMID 20805303 DOI: 10.1124/jpet.110.172742  0.96
2010 Milewski M, Yerramreddy TR, Ghosh P, Crooks PA, Stinchcomb AL. In vitro permeation of a pegylated naltrexone prodrug across microneedle-treated skin. Journal of Controlled Release : Official Journal of the Controlled Release Society. 146: 37-44. PMID 20678989 DOI: 10.1016/j.jconrel.2010.05.034  0.64
2010 Penthala NR, Yerramreddy TR, Madadi NR, Crooks PA. Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters. 20: 4468-71. PMID 20598531 DOI: 10.1016/j.bmcl.2010.06.042  0.96
2010 Vartak AP, Gabriela Deaciuc A, Dwoskin LP, Crooks PA. Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2. Bioorganic & Medicinal Chemistry Letters. 20: 3584-7. PMID 20494575 DOI: 10.1016/j.bmcl.2010.04.117  0.96
2010 Matharu J, Oki J, Worthen DR, Smith QR, Crooks PA. Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier. Bioorganic & Medicinal Chemistry Letters. 20: 3688-91. PMID 20466543 DOI: 10.1016/j.bmcl.2010.04.086  0.96
2010 Zheng G, Zhang Z, Lockman PR, Geldenhuys WJ, Allen DD, Dwoskin LP, Crooks PA. Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry Letters. 20: 3208-10. PMID 20462759 DOI: 10.1016/j.bmcl.2010.04.098  0.96
2010 Yerramreddy TR, Milewski M, Penthala NR, Stinchcomb AL, Crooks PA. Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery. Bioorganic & Medicinal Chemistry Letters. 20: 3280-3. PMID 20451376 DOI: 10.1016/j.bmcl.2010.04.049  0.76
2010 Smith AM, Pivavarchyk M, Wooters TE, Zhang Z, Zheng G, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release. Biochemical Pharmacology. 80: 402-9. PMID 20346923 DOI: 10.1016/j.bcp.2010.03.018  0.96
2010 Banks SL, Pinninti RR, Gill HS, Paudel KS, Crooks PA, Brogden NK, Prausnitz MR, Stinchcomb AL. Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs Journal of Pharmaceutical Sciences. 99: 3072-3080. PMID 20166200 DOI: 10.1002/jps.22083  0.96
2010 Zhang Z, Pivavarchyk M, Subramanian KL, Deaciuc AG, Dwoskin LP, Crooks PA. Novel bis-2,2,6,6-tetramethylpiperidine (bis-TMP) and bis-mecamylamine antagonists at neuronal nicotinic receptors mediating nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 20: 1420-3. PMID 20079634 DOI: 10.1016/j.bmcl.2009.12.089  0.96
2010 Geldenhuys WJ, Manda VK, Mittapalli RK, Van der Schyf CJ, Crooks PA, Dwoskin LP, Allen DD, Lockman PR. Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry Letters. 20: 870-7. PMID 20053562 DOI: 10.1016/j.bmcl.2009.12.079  0.96
2010 Hojahmat M, Horton DB, Norrholm SD, Miller DK, Grinevich VP, Deaciuc AG, Dwoskin LP, Crooks PA. Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorganic & Medicinal Chemistry. 18: 640-9. PMID 20036131 DOI: 10.1016/j.bmc.2009.12.002  0.96
2010 Penthala NR, Yerramreddy TR, Crooks PA. Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines. Bioorganic & Medicinal Chemistry Letters. 20: 591-3. PMID 20006496 DOI: 10.1016/j.bmcl.2009.11.083  0.96
2010 Reddy YT, Sekhar KR, Sasi N, Reddy PN, Freeman ML, Crooks PA. Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents Bioorganic and Medicinal Chemistry Letters. 20: 600-602. PMID 20005706 DOI: 10.1016/j.bmcl.2009.11.082  0.96
2009 Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues. The Journal of Organic Chemistry. 74: 6072-6. PMID 20560567 DOI: 10.1021/jo901082r  0.96
2009 Zheng F, Dwoskin LP, Crooks PA, Zhan CG. First-Principles Determination of Molecular Conformations of Indolizidine (-)-235B' in Solution. Theoretical Chemistry Accounts. 124: 269-278. PMID 20161506 DOI: 10.1007/s00214-009-0607-z  0.96
2009 Worthen DR, Bence AK, Stables JP, Crooks PA. In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity. Bioorganic & Medicinal Chemistry Letters. 19: 5012-5. PMID 19632831 DOI: 10.1016/j.bmcl.2009.07.059  0.96
2009 Sonar VN, Crooks PA. Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 117-124. PMID 18629678 DOI: 10.1080/14756360801915526  0.96
2009 Neelakantan S, Parkin S, Crooks PA. (11R)-13-Dimethylammonio-11,13-dihydro-4,5-epoxycostunolide semifumarate Acta Crystallographica Section E: Structure Reports Online. 65. DOI: 10.1107/S1600536809021941  0.96
2009 Culver JP, Parkin S, Crooks PA. Cis-2,6-Dibenzyl-cyclo-hexa-none Acta Crystallographica Section E: Structure Reports Online. 65. DOI: 10.1107/S1600536809004887  0.96
2009 Vartak AP, Crooks PA. A scalable, enantioselective synthesis of the r2-adrenergic agonist, lofexidine Organic Process Research and Development. 13: 415-419. DOI: 10.1021/op8002689  0.96
2009 Nasim S, Crooks PA. N-Chlorosuccinimide is a convenient oxidant for the synthesis of 2,4-disubstituted 1,2,4-thiadiazolidine-3,5-diones Tetrahedron Letters. 50: 257-259. DOI: 10.1016/j.tetlet.2008.10.136  0.96
2009 Vartak AP, Sonar V, Crooks PA. Rac- and R-(+)-[4,4′,5,5′-2H4]-2- (1′-[2″,6″-dichlorophenoxy]-ethyl)-Δ2- imidazoline (lofexidine) Journal of Labelled Compounds and Radiopharmaceuticals. 52: 431-434. DOI: 10.1002/jlcr.1655  0.96
2008 Vartak AP, Dwoskin LP, Crooks PA. Synthesis of symmetrical 1,5-disubstituted granatanines. Tetrahedron Letters. 49: 6330-6333. PMID 23678188 DOI: 10.1016/j.tetlet.2008.08.066  0.96
2008 Albayati ZA, Dwoskin LP, Crooks PA. Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2024-9. PMID 18617603 DOI: 10.1124/dmd.108.020354  0.96
2008 Nasim S, Crooks PA. Antileukemic activity of aminoparthenolide analogs Bioorganic and Medicinal Chemistry Letters. 18: 3870-3873. PMID 18590961 DOI: 10.1016/j.bmcl.2008.06.050  0.96
2008 Malkawi AH, Al-Ghananeem AM, Crooks PA. Development of a GC-MS assay for the determination of fentanyl pharmacokinetics in rabbit plasma after sublingual spray delivery Aaps Journal. 10: 261-267. PMID 18459057 DOI: 10.1208/s12248-008-9031-x  0.96
2008 Nasim S, Parkin S, Crooks PA. (11R)-13-[2-(4-Hydroxyphenyl)ethyl-amino]-4,5-epoxy-11,13-dihydro- costunolide monohydrate Acta Crystallographica Section E: Structure Reports Online. 64. DOI: 10.1107/S1600536808003863  0.96
2008 Nasim S, Parkin S, Crooks PA. (11R,13R)-13-(Tetra-lin-1-ylamino)-4,5-ep-oxy-11,13-dihydro-costunolide Acta Crystallographica Section E: Structure Reports Online. 64. DOI: 10.1107/S1600536808003322  0.96
2008 Sonar VN, Parkin S, Crooks PA. 3-Ethyl-2-methyl-5-methylene-6,7-di-hydroindol-4(5H)-one Acta Crystallographica Section E: Structure Reports Online. 64. DOI: 10.1107/S1600536807063076  0.96
2008 Worthen DR, Crooks PA. The radiosensitizing effects of L-canavanine Herbal Radiomodulators: Applications in Medicine, Homeland Defence and Space. 255-269.  0.96
2007 Sonar VN, Parkin S, Crooks PA. (E)-3-(Benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile Acta Crystallographica Section C: Crystal Structure Communications. 63. PMID 18057629 DOI: 10.1107/S0108270107054959  0.96
2007 Al-Ghananeem AM, Crooks PA. Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and delivery Molecules. 12: 373-388. PMID 17851396 DOI: 10.3390/12030373  0.96
2007 Ring JR, Parkin S, Crooks PA. (4-Meth-oxy-3-nitro-benzyl-idene-amino)-guanidinium chloride Acta Crystallographica Section C: Crystal Structure Communications. 63. PMID 17609569 DOI: 10.1107/S0108270107023475  0.96
2007 Sonar VN, Parkin S, Crooks PA. (Z)-2-(1-Benzyl-5-nitro-1H-indol-3-ylmethyl-ene)-1-aza-bicyclo-[2.2.2] octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 63. PMID 17284808 DOI: 10.1107/S0108270106055971  0.96
2007 Papke RL, Dwoskin LP, Crooks PA. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery. Journal of Neurochemistry. 101: 160-7. PMID 17241116 DOI: 10.1111/j.1471-4159.2006.04355.x  0.96
2007 Nasim S, Parkin S, Crooks PA. (11R)-13-(1-Naphthylmethylamino)-4,5-epoxy-11,13-dihydrocostunolide Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807046983  0.96
2007 Sonar VN, Parkin S, Crooks PA. (Z)-3-[1-(4-Chloro-benz-yl)-1H-indol-3-yl]-2-(3-thien-yl)acrylonitrile Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807042638  0.96
2007 Nasim S, Parkin S, Crooks PA. (11R)-13-(Benzyl-amino)-4,5-ep-oxy-11,13-dihydro-costunolide Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807041712  0.96
2007 Sonar VN, Parkin S, Crooks PA. Rac-(Z)-2-(1-Naphthyl-methyl-ene)-1-aza-bicyclo-[2.2.2]octan-3-ol Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807041682  0.96
2007 Sonar VN, Parkin S, Crooks PA. Rac-(Z)-2-(2,4-Dichloro-benzyl-idene)-1-aza-bicyclo-[2.2.2]octan-3-ol Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807041128  0.96
2006 Zheng G, Dwoskin LP, Crooks PA. Vesicular monoamine transporter 2: role as a novel target for drug development. The Aaps Journal. 8: E682-92. PMID 17233532 DOI: 10.1208/aapsj080478  0.96
2006 Al-Ghananeem AM, Malkawi AH, Crooks PA. Effect of pH on sublingual absorption of oxycodone hydrochloride Aaps Pharmscitech [Electronic Resource].. 7. PMID 16584154 DOI: 10.1208/pt070123  0.96
2006 Sonar VN, Parkin S, Crooks PA. 1-(1H-Indol-3-ylcarbonyl)-N-(4-methoxybenzyl)formamide Acta Crystallographica Section C: Crystal Structure Communications. 62. PMID 16518054 DOI: 10.1107/S0108270106003441  0.96
2006 Sonar VN, Sean P, Crooks PA. 1-(Azepan-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806029837  0.96
2006 Sonar VN, Parkin S, Crooks PA. 1-(4-tert-Butylbenzyl)-1H-indole-3-carbaldehyde Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806026900  0.96
2006 Sonar VN, Parkin S, Crooks PA. (E)-1-benzyl-3-(2-nitrovinyl)-1H-indole Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806026523  0.96
2006 Sonar VN, Parkin S, Crooks PA. 1-(4-Methoxybenzyl)-1H-indole-3-carbaldehyde Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806025268  0.96
2006 Sonar VN, Parkin S, Crooks PA. Methyl (E)-2-cyano-3-(1H-indol-3-yl)acrylate Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806004892  0.96
2006 Sonar VN, Parkin S, Crooks PA. (Z)-2-[1-(4-Methylphenylsulfonyl)-1H-indol-3-ylmethylene]-1-azabicyclo[2.2. 2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806001103  0.96
2006 Sonar VN, Parkin S, Crooks PA. (Z)-2-(4-Methoxybenzylidene)-1-azabicyclo[2.2.2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536805042637  0.96
2006 Sonar VN, Parkin S, Crooks PA. (Z)-2-(2-Methoxybenzylidene)-1-azabicyclo[2.2.2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536805042625  0.96
2006 Sonar VN, Parkin S, Crooks PA. N-(2,5-Dichlorophenyl)-N′-[(E)-3-thienyl-methylene]hydrazine Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S160053680501634X  0.96
2005 Ayers JT, Xu R, Dwoskin LP, Crooks PA. A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine. The Aaps Journal. 7: E752-8. PMID 16353951 DOI: 10.1208/aapsj070375  0.96
2005 Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-Methoxybenzylidene)-1-aza-bicyclo[2.2.2]octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 61. PMID 16272604 DOI: 10.1107/S0108270105030593  0.96
2005 Sonar VN, Parkin S, Crooks PA. (E)-2-Methyl-3-(2-methyl-2-nitrovinyl)-1H-indole and (E)-3-(2-methyl-2- nitrovinyl)-2-phenyl-1H-indole Acta Crystallographica Section C: Crystal Structure Communications. 61. PMID 16082109 DOI: 10.1107/S0108270105022298  0.96
2005 Sonar VN, Parkin S, Crooks PA. (Z)-3-(1H-Indol-3-yl)-2-(3-thienyl)-acrylonitrile and (Z)-3-[1-(4-tert- butylbenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile Acta Crystallographica Section C: Crystal Structure Communications. 61. PMID 15695916 DOI: 10.1107/S0108270104032925  0.96
2005 Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-Nitrobenzylidene)-1-azabicyclo[2.2.2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S1600536805028576  0.96
2005 Sonar VN, Parkin S, Crooks PA. 6α-Acetoxy-4,5α-epoxy-3-methoxy-17-methyl-morphin-7-ene Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S1600536805022130  0.96
2005 Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-Thienyl)-3-(3,4,5-trimethoxyphenyl)-acrylonitrile Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S160053680500680X  0.96
2004 Zheng G, Dwoskin LP, Crooks PA. Indirect trapping of the retroconjugate addition reaction intermediate involved in the epimerization of lobeline: application to the synthesis of (-)-sedamine. The Journal of Organic Chemistry. 69: 8514-7. PMID 15549833 DOI: 10.1021/jo048848j  0.96
2004 Sonar VN, Parkin S, Crooks PA. (Z)-2-(1-Phenylsulfonyl-1H-indol3-ylmethylene)-1-azabicyclo[2.2.2] -octan-3-one and (Z)-(S)-2-(1-phenylsulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2] octan-3-ol Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 15345848 DOI: 10.1107/S0108270104015847  0.96
2004 Sonar VN, Parkin S, Crooks PA. (E)-N-[(Benzo[b]thiophen-3-yl)methylene]-N′-(2,5-dichlorophenyl) -hydrazine Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 15295184 DOI: 10.1107/S0108270104013873  0.96
2004 Sonar VN, Parkin S, Crooks PA. 1-(2,5-Dichlorophenyl)-3-methyl-5-phenyl-1H-pyrazole Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 15295183 DOI: 10.1107/S0108270104013848  0.96
2004 Sonar VN, Parkin S, Crooks PA. (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 15004388 DOI: 10.1107/S0108270104002550  0.96
2004 Sonar VN, Parkin S, Crooks PA. (Z)-2-(1H-Indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 14712032 DOI: 10.1107/S0108270103026076  0.96
2004 Sonar VN, Parkin S, Crooks PA. 4-(Benzo[b]thiophen-3-yl)-1-methylpiperidine-4-carbonitrile Acta Crystallographica Section E: Structure Reports Online. 60. DOI: 10.1107/S1600536804019543  0.96
2004 Zheng G, Dwoskin LP, Crooks PA. The preparation of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octan-3- ones Synthetic Communications. 34: 1931-1942. DOI: 10.1081/SCC-120037905  0.96
2004 Sonar VN, Parkin S, Crooks PA. 2-(1-Methyl-1H-indol-3-ylmethylene)-1-aza-bicyclo[2.2.2] octan-3-one: Acid-catalyzed isomerization of the Z isomer to the E isomer Journal of Chemical Crystallography. 34: 239-244. DOI: 10.1023/B:JOCC.0000022421.28337.de  0.96
2003 Bence AK, Crooks PA. The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery. Journal of Enzyme Inhibition and Medicinal Chemistry. 18: 383-94. PMID 14692504 DOI: 10.1080/1475636031000152277  0.96
2003 Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-hydroxy-4-methoxybenzyl-idene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 59. PMID 14605418 DOI: 10.1107/S0108270103022339  0.96
2003 Grinevich VP, Crooks PA, Sumithran SP, Haubner AJ, Ayers JT, Dwoskin LP. N-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices. The Journal of Pharmacology and Experimental Therapeutics. 306: 1011-20. PMID 12766255 DOI: 10.1124/jpet.103.051789  0.96
2003 Bence AK, Adams VR, Crooks PA. L-Canavanine as a radiosensitization agent for human pancreatic cancer cells. Molecular and Cellular Biochemistry. 244: 37-43. PMID 12701807 DOI: 10.1023/A:1022435202066  0.96
2003 de Leon J, Diaz FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OA, Dwoskin LP, Crooks PA. Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokers. Journal of Clinical Psychopharmacology. 23: 209-11. PMID 12640226 DOI: 10.1097/00004714-200304000-00018  0.96
2003 Bence AK, Worthen DR, Stables JP, Crooks PA. An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine. Pharmacology, Biochemistry, and Behavior. 74: 771-5. PMID 12543244 DOI: 10.1016/S0091-3057(02)01079-1  0.96
2003 Sonar VN, Parkin S, Crooks PA. (Z)-2-(2,4-dimethoxybenzylidene)-1-aza-bicyclo[2.2.2]octan-3-ol Acta Crystallographica Section E: Structure Reports Online. 59. DOI: 10.1107/S1600536803026825  0.96
2003 Sonar VN, Parkin S, Crooks PA. 2-(1-Benzyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section E: Structure Reports Online. 59. DOI: 10.1107/S1600536803019809  0.96
2003 Sonar VN, Parkin S, Crooks PA. (Z)-2-Thiophen-3-ylmethylene-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section E: Structure Reports Online. 59. DOI: 10.1107/S1600536803019007  0.96
2003 Wei X, Crooks PA. An improved synthesis of β-Nicotyrine from the dehydrogenation of nicotine: Comparison of conventional and microwave-assisted reactions Synthetic Communications. 33: 3305-3315. DOI: 10.1081/SCC-120023988  0.96
2002 Ring JR, Haubner AJ, Crooks PA. Novel antiepileptic and anticonvulsive therapeutic agents. Idrugs : the Investigational Drugs Journal. 5: 990-9. PMID 12800062  0.96
2002 Bence AK, Worthen DR, Adams VR, Crooks PA. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anti-Cancer Drugs. 13: 313-20. PMID 11984075 DOI: 10.1097/00001813-200203000-00013  0.96
2002 Dwoskin LP, Crooks PA. A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse. Biochemical Pharmacology. 63: 89-98. PMID 11841781 DOI: 10.1016/S0006-2952(01)00899-1  0.96
2002 Crooks PA, Matheru J. Synthesis of endo-12-aminotricyclo[6.3.2.02,7]Trideca-2(7),3, 5-triene-12-exo-carboxylic acid: A novel, conformationally restricted phenylalanine analogue Synthetic Communications. 32: 3813-3819. DOI: 10.1081/SCC-120015400  0.96
2002 Bence AK, Crooks PA. Synthesis of L-indospicine Synthetic Communications. 32: 2075-2082. DOI: 10.1081/SCC-120004860  0.96
2001 Dwoskin LP, Teng LH, Crooks PA. Nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum. European Journal of Pharmacology. 428: 69-79. PMID 11779039 DOI: 10.1016/S0014-2999(01)01283-3  0.96
2001 Dwoskin LP, Crooks PA. Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery. The Journal of Pharmacology and Experimental Therapeutics. 298: 395-402. PMID 11454899  0.96
2001 Ghosheh OA, Dwoskin LP, Miller DK, Crooks PA. Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2'-(14)C]nicotine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 645-51. PMID 11302929  0.96
2001 Worthen DR, Gibson DA, Rogers DT, Bence AK, Fu M, Littleton JM, Crooks PA. Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex. Brain Research. 890: 343-6. PMID 11164802 DOI: 10.1016/S0006-8993(00)03201-7  0.96
2000 Hussain AA, Jona J, Crooks PA. Competitive inhibitory effect of external nucleophile concentration on intramolecular O- to N-acylation in O-acetylsalicylamide Aaps Pharmscitech [Electronic Resource]. 1. PMID 14727901  0.96
2000 Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex. Bioorganic & Medicinal Chemistry Letters. 10: 2621-3. PMID 11128637 DOI: 10.1016/S0960-894X(00)00530-8  0.96
2000 Miller DK, Crooks PA, Dwoskin LP. Lobeline inhibits nicotine-evoked [(3)H]dopamine overflow from rat striatal slices and nicotine-evoked (86)Rb(+) efflux from thalamic synaptosomes. Neuropharmacology. 39: 2654-62. PMID 11044735 DOI: 10.1016/S0028-3908(00)00140-4  0.96
2000 Ghosheh OA, Browne D, Rogers T, de Leon J, Dwoskin LP, Crooks PA. A simple high performance liquid chromatographic method for the quantification of total cotinine, total 3'-hydroxycotinine and caffeine in the plasma of smokers. Journal of Pharmaceutical and Biomedical Analysis. 23: 543-9. PMID 10933548 DOI: 10.1016/S0731-7085(00)00339-3  0.96
2000 Dwoskin LP, Xu R, Ayers JT, Crooks PA. Recent developments in neuronal nicotinic acetylcholine receptor antagonists Expert Opinion On Therapeutic Patents. 10: 1561-1581.  0.96
1999 Ghosheh OA, Houdi AA, Crooks PA. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). Journal of Pharmaceutical and Biomedical Analysis. 19: 757-62. PMID 10698539 DOI: 10.1016/S0731-7085(98)00300-8  0.96
1998 Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Research. 18: 1527-32. PMID 9673365  0.96
1998 Teng L, Crooks PA, Dwoskin LP. Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine. Journal of Neurochemistry. 71: 258-65. PMID 9648873  0.96
1998 Crooks PA, Ravard A, Byrd GD. Synthesis of (E)-N-[methyl-d3]- 4-(3-pyridinyl)-3-buten-1-amine, a deuterated analogue of the nicotinic agonist RJR-2403 Journal of Labelled Compounds and Radiopharmaceuticals. 41: 1165-1171. DOI: 10.1002/(SICI)1099-1344(199812)41:12<1165::AID-JLCR162>3.0.CO;2-G  0.96
1997 Teng L, Crooks PA, Buxton ST, Dwoskin LP. Nicotinic-receptor mediation of S(-)nornicotine-evoked -3H-overflow from rat striatal slices preloaded with -3H-dopamine. The Journal of Pharmacology and Experimental Therapeutics. 283: 778-87. PMID 9353398  0.96
1997 Crooks PA, Dwoskin LP. Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking. Biochemical Pharmacology. 54: 743-53. PMID 9353128 DOI: 10.1016/S0006-2952(97)00117-2  0.96
1997 Teng L, Crooks PA, Sonsalla PK, Dwoskin LP. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. The Journal of Pharmacology and Experimental Therapeutics. 280: 1432-44. PMID 9067333  0.96
1997 Crooks PA, Li M, Dwoskin LP. Metabolites of nicotine in rat brain after peripheral nicotine administration. Cotinine, nornicotine, and norcotinine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 25: 47-54. PMID 9010629  0.96
1996 Houdi AA, Kottayil S, Crooks PA, Butterfield DA. 3-O-Acetylmorphine-6-O-Sulfate: A potent, centrally acting morphine derivative Pharmacology Biochemistry and Behavior. 53: 665-671. PMID 8866970 DOI: 10.1016/0091-3057(95)02067-5  0.96
1996 Deo NM, Crooks PA. Regioselective alkylation of N-(diphenylmethylidine)-3-(aminomethyl)pyridine: A simple route to minor tobacco alkaloids and related compounds Tetrahedron Letters. 37: 1137-1140. DOI: 10.1016/0040-4039(96)00002-0  0.96
1996 Ravard A, Crooks PA. Chiral purity determination of tobacco alkaloids and nicotine-like compounds by 1H NMR spectroscopy in the presence of 1,1'-binaphthyl-2,2'- diylphosphoric acid Chirality. 8: 295-299. DOI: 10.1002/(SICI)1520-636X(1996)8:4<295::AID-CHIR1>3.0.CO;2-F  0.96
1996 Brock CP, Kottayil S, Butterfield DA, Crooks PA. A dihydromorphine-6-O-sulfate Acta Crystallographica Section C: Crystal Structure Communications. 52: 122-125.  0.96
1995 Crooks PA, Li M, Dwoskin LP. Determination of nicotine metabolites in rat brain after peripheral radiolabeled nicotine administration: detection of nornicotine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 23: 1175-7. PMID 8654207  0.96
1995 Deo NM, Crooks PA. Synthesis of 2-cyanomethyl-1-methylpiperidine Synthetic Communications. 25: 691-701. DOI: 10.1080/00397919508011406  0.96
1995 Cynkowski T, Cynkowska G, Ashton P, Crooks PA. Reaction of N-benzoyl amino acids with oxalyl chloride: A facile route to 4-substituted 2-phenyloxazole-5-carboxylates Journal of the Chemical Society, Chemical Communications. 2335-2336. DOI: 10.1039/C39950002335  0.96
1995 Chen J, Crooks PA, Hussain A. Kinetics and mechanism of hydrolysis of amidals: Their relative stability compared to structurally related acetals and acylals International Journal of Pharmaceutics. 123: 95-101. DOI: 10.1016/0378-5173(95)00044-J  0.96
1994 Ravard A, Crooks PA. Synthesis of racemic [methyl‐d3]‐iabeled cis‐ and trans‐3′‐hydroxycotinine Journal of Labelled Compounds and Radiopharmaceuticals. 34: 1001-1009. DOI: 10.1002/jlcr.2580341102  0.96
1993 Dwoskin LP, Buxton ST, Jewell AL, Crooks PA. S(-)-nornicotine increases dopamine release in a calcium-dependent manner from superfused rat striatal slices. Journal of Neurochemistry. 60: 2167-74. PMID 8492124  0.96
1993 Hussain AA, Awad R, Crooks PA, Dittert LW. Chloramine-T in Radiolabeling Techniques. I. Kinetics and Mechanism of the Reaction between Chloramine-T and Amino Acids Analytical Biochemistry. 214: 495-499. PMID 8109739 DOI: 10.1006/abio.1993.1528  0.96
1993 Gogineni PV, Crooks PA, Murty RB. Gas chromatographic determination of residual levels of tert.-butanol from lyophilized liposomal formulations Journal of Chromatography B: Biomedical Sciences and Applications. 620: 83-88. PMID 8106595 DOI: 10.1016/0378-4347(93)80054-8  0.96
1993 Houdi AA, Godin CS, Crooks PA. Detection of a possible biomarker for sidestream cigarette smoke exposure Pharmaceutical Science Communications. 4: 15-20.  0.96
1992 Allen DD, Crooks PA, Yokel RA. 4-trimethylammonium antipyrine: A quaternary ammonium nonradionuclide marker for blood-brain barrier integrity during in vivo microdialysis Journal of Pharmacological and Toxicological Methods. 28: 129-135. PMID 1489983 DOI: 10.1016/1056-8719(92)90074-B  0.96
1992 Dannan H, Hussain A, Crooks PA, Dittert LW. Structure—activity considerations in kinetics and mechanism of chlorine exchange between chloramine‐T and secondary amines Journal of Pharmaceutical Sciences. 81: 657-660. PMID 1403699 DOI: 10.1002/jps.2600810713  0.96
1992 Dannan H, Crooks PA, Dittert LW, Hussain A. Kinetics and mechanism of chlorine exchange between chloramine‐T and secondary amines Journal of Pharmaceutical Sciences. 81: 652-656. PMID 1403698 DOI: 10.1002/jps.2600810712  0.96
1992 Crooks PA, Sherratt AJ, Godin CS. Oxidative metabolism of nicotine enantiomers in isolated guinea pig hepatocytes Medical Science Research. 20: 909-911.  0.96
1992 Crooks PA, Godin CS, Pool WF. Enantiomeric purity of nicotine in tobacco smoke condensate Medical Science Research. 20: 879-880.  0.96
1990 Tawfig FA, Dittert L, Hussain A, Crooks PA. Rearrangement of O-acetylsalicylamides via intramolecular O-to-N transacylation: Rate enhancement by an adjacent carboxylic acid group Journal of Pharmaceutical Sciences. 79: 651. PMID 2398477 DOI: 10.1002/jps.2600790724  0.96
1990 Awad R, Hussain A, Crooks PA. Kinetics and mechanism of decomposition of N-chloroamino acids. II: Conformationally restricted models Journal of Pharmaceutical Sciences. 79: 1121-1122. PMID 2079660 DOI: 10.1002/jps.2600791216  0.96
1990 Tawfiq FA, Hussain A, Dittert L, Crooks PA. Kinetics of decomposition of O-acyl derivatives of salicylamide and related compounds International Journal of Pharmaceutics. 64: 45-53. DOI: 10.1016/0378-5173(90)90177-6  0.96
1990 Awad R, Hussain A, Crooks PA. Kinetics and mechanism of decomposition of N-chloro-α-amino acids Journal of the Chemical Society, Perkin Transactions 2. 1233-1238.  0.96
1989 Goldsmith SR, Dodge-Brown D, Katz A, Crooks PA. Differential effect of nicotine on plasma norepinephrine levels in normal humans and in patients with congestive heart failure The American Journal of Cardiology. 63: 122-123. PMID 2909144 DOI: 10.1016/0002-9149(89)91095-3  0.96
1989 Bawarshi-Nassar RN, Husain AA, Crooks PA. Nasal absorption and metabolism of progesterone and 17β-estradiol in the rat Drug Metabolism and Disposition. 17: 248-254. PMID 2568904  0.96
1989 BAWARSHI‐NASSAR RN, HUSSAIN A, CROOKS PA. Nasal absorption of 17α‐ethinyloestradiol in the rat Journal of Pharmacy and Pharmacology. 41: 214-215. PMID 2568456 DOI: 10.1111/j.2042-7158.1989.tb06436.x  0.96
1989 Godin CS, Crooks PA. N-Methylation as a toxication route for xenobiotics. II. In vivo formation of N,N'-dimethyl-4,4'-bipyridyl ion (Paraquat) from 4,4'-bipyridyl in the guinea pig Drug Metabolism and Disposition. 17: 180-185. PMID 2565208  0.96
1989 Crooks PA, Deeks T, Desimone F. Synthesis of 5‐benzoyl‐5‐phenyl‐ and 5‐phenylhydroxymethyl‐5‐phenylhydantoins as potential anticonvulsants Journal of Heterocyclic Chemistry. 26: 1113-1117. DOI: 10.1002/jhet.5570260439  0.96
1988 Chien C‐, Diana JN, Crooks PA. High‐performance liquid chromatography with electrochemical detection for the determination of nicotine in plasma Journal of Pharmaceutical Sciences. 77: 277-279. PMID 3373433 DOI: 10.1002/jps.2600770319  0.96
1988 Nwosu CG, Crooks PA. Species variation and stereoselectivity in the metabolism of nicotine enantiomers. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 18: 1361-72. PMID 3245230 DOI: 10.3109/00498258809042260  0.96
1988 Houdi AA, Godin CS, Crooks PA. Effect of continuous administration of nicotine on urinary histamine and Nτ-methylhistamme levels in the guinea pig Toxicology Letters. 44: 161-166. PMID 3188074 DOI: 10.1016/0378-4274(88)90142-7  0.96
1988 Goldsmith SR, Katz A, Crooks PA. Response of plasma arginine vasopressin to nicotine in normal man Clinical Pharmacology and Therapeutics. 44: 478-481. PMID 3168397  0.96
1988 WINKLE SA, CROOKS PA. Equilibrium binding of spermine and histamine to salmon sperm DNA and poly(dGdC) Journal of Pharmacy and Pharmacology. 40: 809-811. PMID 2907565 DOI: 10.1111/j.2042-7158.1988.tb05179.x  0.96
1988 POOL WF, CROOKS PA. Biotransformation of Primary Nicotine Metabolites: Metabolism of R‐(+)‐[3H‐N′‐CH3; 14C‐N‐CH3] N‐Methylnicotinium Acetate—The Use of Double Isotope Studies to Determine the In‐vivo Stability of the N‐Methyl Groups of N‐Methylnicotinium Ion Journal of Pharmacy and Pharmacology. 40: 758-762. PMID 2907553 DOI: 10.1111/j.2042-7158.1988.tb05167.x  0.96
1988 GAIROLA C, GODIN CS, HOUDI AA, CROOKS PA. Inhibition of histamine N‐methyltransferase activity in guinea‐pig pulmonary alveolar macrophages by nicotine Journal of Pharmacy and Pharmacology. 40: 724-726. PMID 2907542 DOI: 10.1111/j.2042-7158.1988.tb07004.x  0.96
1988 Crooks PA, Godin CS. N‐Methylation of nicotine enantiomers by human liver cytosol Journal of Pharmacy and Pharmacology. 40: 153-154. PMID 2897456 DOI: 10.1111/j.2042-7158.1988.tb05207.x  0.96
1987 Cundy KC, Crooks PA. Biotransformation of primary nicotine metabolites II. Metabolism of [3h]-s-(-)-cotinine in the Guinea pig: Determination of in vivo urinary metabolites by high-performance liquid-radiochromatography Xenobiotica. 17: 785-792. PMID 3660848 DOI: 10.3109/00498258709043987  0.96
1986 Benghiat E, Crooks PA, Goodwin R, Rottman F. Inhibition of vaccinia RNA guanine 7-methyltransferase by compounds designed as multisubstrate adducts Journal of Pharmaceutical Sciences. 75: 142-145. PMID 3958922 DOI: 10.1002/jps.2600750207  0.96
1986 Godin CS, Crooks PA, Damani LA. N-methylation of phenylpyridines and bispyridyls as a potential toxication route: Tissue distribution of azaheterocycle n-methyltransferase activity in the rabbit Toxicology Letters. 34: 217-222. PMID 3798480 DOI: 10.1016/0378-4274(86)90213-4  0.96
1986 Godin CS, Crooks PA. In vitro inhibition of histamine metabolism in guinea pig lung by S‐(−)‐nicotine Journal of Pharmaceutical Sciences. 75: 949-951. PMID 3795025 DOI: 10.1002/jps.2600751007  0.96
1986 Crooks PA, Burn P, Sewell RD, Upton N. Synthesis and antinociceptive properties of a series of exo- and endo-6-hydroxy-2-aminobenzonorbornenes. Journal of Pharmaceutical Sciences. 75: 1010-3. PMID 3795019 DOI: 10.1002/jps.2600751022  0.96
1986 Godin CS, Crooks PA. In vivo depletion of S-adenosyl-l-homocysteine and S-adenosyl-l-methionine in guinea pig lung after chronic S-(-)-nicotine administration Toxicology Letters. 31: 23-29. PMID 3715913 DOI: 10.1016/0378-4274(86)90190-6  0.96
1985 Mousa S, van Loon GR, Houdi AA, Crooks PA. High-performance liquid chromatography with electrochemical detection for the determination of nicotine and N-methylnicotinium ion Journal of Chromatography A. 347: 405-410. PMID 4077941 DOI: 10.1016/S0021-9673(01)95514-1  0.96
1985 Crooks PA, Krechniak JW, Olson JW, Gillespie MN. High-performance liquid chromatographic analysis of pulmonary metabolites of Leu- and Met-enkephalins in isolated perfused rat lung Journal of Pharmaceutical Sciences. 74: 1010-1012. PMID 4067842 DOI: 10.1002/jps.2600740923  0.96
1985 Olson JW, Crooks PA. Effect of nicotine and n'-nitrosonornicotine on rat lung and trachea ornithine decarboxylase activity Carcinogenesis. 6: 1517-1519. PMID 4042278 DOI: 10.1093/carcin/6.10.1517  0.96
1985 Sommerville R, Rosenberg HE, Crooks PA. Synthesis and pharmacological evaluation of aromatic dihydroxylated spiro[indan‐1,3′‐pyrrolidine] and spiro[indan‐2,2′‐pyrrolidine] derivatives Journal of Pharmaceutical Sciences. 74: 553-555. PMID 4020632 DOI: 10.1002/jps.2600740512  0.96
1985 Cundy KC, Crooks PA, Steven Godin C. Remarkable substrate-inhibitor properties of nicotine enantiomers towards a guinea pig lung aromatic azaheterocycle N-methyltransferase Biochemical and Biophysical Research Communications. 128: 312-316. PMID 3985972 DOI: 10.1016/0006-291X(85)91680-8  0.96
1985 Cundy KC, Godin CS, Crooks PA. Stereospecific in vitro N-methylation of nicotine in guinea pig tissues by an S-adenosylmethionine-dependent N-methyltransferase Biochemical Pharmacology. 34: 281-284. PMID 3966930 DOI: 10.1016/0006-2952(85)90137-6  0.96
1985 Cundy KC, Crooks PA. In vitro characteristics of guinea pig lung aromatic azaheterocycle N-methyltransferase Drug Metabolism and Disposition. 13: 658-663. PMID 2867867  0.96
1985 Pool WF, Crooks PA. Biotransformation of primary nicotine metabolites. I. In vivo metabolism of R-(+)-[14C-NCH3]N-methylnicotinium ion in the guinea pig Drug Metabolism and Disposition. 13: 578-581. PMID 2865106  0.96
1985 Sato M, Crooks PA. N-methylnornicotinium ion, a new in vivo metabolite of R-(+)-nicotine Drug Metabolism and Disposition. 13: 348-353. PMID 2861995  0.96
1985 Cundy KC, Sato M, Crooks PA. Stereospecific in vivo N-methylation of nicotine in the guinea pig Drug Metabolism and Disposition. 13: 175-185. PMID 2859165  0.96
1984 Waigh RD, Deeks T, Crooks PA. Leucine enkephalin analogues containing a conformationally restrained N‐terminal amino acid residue Journal of Pharmaceutical Sciences. 73: 457-460. PMID 6726628 DOI: 10.1002/jps.2600730408  0.96
1984 Cundy KC, Crooks PA. High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine Journal of Chromatography B: Biomedical Sciences and Applications. 306: 291-301. PMID 6715467 DOI: 10.1016/S0378-4347(00)80891-9  0.96
1984 Cundy KC, Godin CS, Crooks PA. Evidence of stereospecificity in the in vivo methylation of [14C](±)-nicotine in the guinea pig Drug Metabolism and Disposition. 12: 755-759. PMID 6150826  0.96
1984 Crooks PA, Tribé MJ, Pinney RJ. Inhibition of bacterial DNA cytosine‐5‐methyltransferase by S‐adenosyl‐l‐homocysteine and some related compounds Journal of Pharmacy and Pharmacology. 36: 85-89. PMID 6143811 DOI: 10.1111/j.2042-7158.1984.tb02999.x  0.96
1983 Deeks T, Crooks PA, Waigh RD. Synthesis and analgesic properties of two leucine-enkephalin analogues containing a conformationally restrained N-terminal tyrosine residue Journal of Medicinal Chemistry. 26: 762-765. PMID 6842517  0.96
1983 Daoud NN, Crooks PA, Speak R, Gilbert P. Determination of benzalkonium chloride by chemical ionization mass spectroscopy Journal of Pharmaceutical Sciences. 72: 290-292. PMID 6842381 DOI: 10.1002/jps.2600720320  0.96
1983 Benghiat E, Crooks PA. Multisubstrate adducts as potential inhibitors of S-adenosylmethionine dependent methylases: Inhibition of indole N-methyltransferase by (5′-deoxyadenosyl)[3-(3-indolyl)prop-1-yl]methylsulfonium and (5′-deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium salts Journal of Medicinal Chemistry. 26: 1470-1477. PMID 6620306  0.96
1983 Hicks PE, Waldron C, Burn P, Crooks PA. alpha 2-Adrenoceptor agonist properties of exo- and endo-isomers of 2-amino-6,7,dihydroxybenzonorbornene designed as rigid catecholamines. The Journal of Pharmacy and Pharmacology. 35: 94-9. PMID 6131993 DOI: 10.1111/j.2042-7158.1983.tb04276.x  0.96
1983 Cundy KC, Crooks PA. Unexpected pehnomenon in the high-performance liquid chromatographic anlaysis of racemic 14C-labelled nicotine: Separation of enantiomers in a totally achiral system Journal of Chromatography A. 281: 17-33. DOI: 10.1016/S0021-9673(01)87863-8  0.96
1983 Benghiat E, Crooks PA. Synthesis of s‐3‐indolemethyl derivatives of 5′‐deoxy‐5′‐thioadenosine Journal of Heterocyclic Chemistry. 20: 423-425. DOI: 10.1002/jhet.5570200229  0.96
1982 Shaker MS, Crooks PA, Damani LA. High-performance liquid chromatographic analysis of the in vivo metabolites of [14C]pyridine Journal of Chromatography A. 237: 489-495. PMID 7096490 DOI: 10.1016/S0021-9673(00)97638-6  0.96
1982 Crooks PA, Sommerville R. The synthesis and analgesic activities of some spiro[indan‐1,3′‐pyrrolidine] derivatives designed as rigid analogs of profadol Journal of Pharmaceutical Sciences. 71: 291-294. PMID 6461753 DOI: 10.1002/jps.2600710306  0.96
1982 Crooks PA, DeSimone F, Ramundo E. Synthesis of 2,3,3a,8a‐tetrahydroindeno[2,1‐b]pyrrole derivatives Journal of Heterocyclic Chemistry. 19: 1433-1436. DOI: 10.1002/jhet.5570190635  0.96
1982 Banghiat E, Crooks PA. Synthesis of 7-deazaguanine (2-amino-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one) analogues substituted at C-8 Chemistry and Industry (London). 661-662.  0.96
1981 Damani LA, Crooks PA, Cowan DA. Metabolism of metyrapone: 2—chromatographic and mass spectral properties of the N‐oxides of metyrapone and metyrapol Biological Mass Spectrometry. 8: 270-277. PMID 7260343 DOI: 10.1002/bms.1200080609  0.96
1981 CROOKS PA, DAMANI LA, COWAN DA. Synthesis of N‐oxide derivatives of metyrapone and their detection as in vitro metabolites Journal of Pharmacy and Pharmacology. 33: 309-312. PMID 6116779 DOI: 10.1111/j.2042-7158.1981.tb13786.x  0.96
1981 Damani LA, Crooks PA, Cowan DA. Metabolism of metyrapone. III. Formation of an α-pyridone metabolite by rat hepatic soluble enzymes Drug Metabolism and Disposition. 9: 270-273. PMID 6113939  0.96
1981 Burn P, Crooks PA, Waldron C, Hicks PE. α‐ADRENOCEPTOR PROPERTIES OF SOME DIHYDROXYBENZONORBORNENES DESIGNED AS RIGID CATECHOLAMINES Journal of Pharmacy and Pharmacology. 33: 83P-83P. DOI: 10.1111/j.2042-7158.1981.tb11742.x  0.96
1981 Tribe MJ, Pinney RJ, Crooks PA. INHIBITION OF BACTERIAL DNA METHYLATION BY S‐TUBERCIDINYLHOMOCYSTEINE (STH) Journal of Pharmacy and Pharmacology. 33: 80P-80P. DOI: 10.1111/j.2042-7158.1981.tb11739.x  0.96
1981 Shaker MS, Crooks PA, Damani LA. METABOLIC C‐ AND N‐OXIDATION AND N‐METHYLATION OF [2,614C] PYRIDINE IN VIVO: DETERMINATION OF URINARY METABOLITES BY H.P.L.C Journal of Pharmacy and Pharmacology. 33: 10P-10P. DOI: 10.1111/j.2042-7158.1981.tb11669.x  0.96
1981 Daoud NN, Crooks PA, Gilbert P. IDENTIFICATION OF COMPONENT ALKYL CHAINS WITHIN COMMERCIAL SAMPLES OF BENZALKONIUM CHLORIDE MIXTURES BY CHEMICAL IONISATION MASS SPECTROMETRY Journal of Pharmacy and Pharmacology. 33: 8P-8P. DOI: 10.1111/j.2042-7158.1981.tb11667.x  0.96
1981 Crooks PA, Damani LA, Cowan DA. Baeyer-Villiger oxidation of metyrapone during n-oxide formation Chemistry and Industry (London). 335-336.  0.96
1981 Shaker MS, Crooks PA, Damani LA. Metabolic C- and N-oxidation and N-methylation of [2,614C]pyridine in vivo: Determination of urinary metabolites by H.P.L.C Journal of Pharmacy and Pharmacology. 33.  0.96
1980 Crooks PA, Szyndler R, Cox B. 5,6- and 6,7-dihydroxyspiro (tetralin-1,3'-pyrrolidine): conformationally restricted analogues of dopamine Pharmaceutica Acta Helvetiae. 55: 134-137. PMID 7403196  0.96
1980 Crooks PA, Szyndler R. Synthesis and analgesic properties of some conformationally restricted analogues of profadol Journal of Medicinal Chemistry. 23: 679-682. PMID 6446605  0.96
1980 BURN P, CROOKS PA, RATCLIFFE BL, REES JMH. Sympathomimetic effects of exo‐ and endo‐ isomers of 2‐aminobenzonorbornene in vitro and in vivo Journal of Pharmacy and Pharmacology. 32: 87-91. PMID 6103048 DOI: 10.1111/j.2042-7158.1980.tb12858.x  0.96
1980 Ginawi OT, Burn P, Crooks PA, Rees JMH. THE ROLE OF BRAIN 5‐HYDROXYTRYPTAMINE IN THE ANALGESIC ACTION OF CENTRALLY ACTING SYMPATHOMIMETICS Journal of Pharmacy and Pharmacology. 32: 77P-77P. DOI: 10.1111/j.2042-7158.1980.tb10880.x  0.96
1980 Crooks PA. Synthesis of 2-amino-1,3-dihydroxyindanes Chemistry and Industry (London). 467-468.  0.96
1979 Damani LA, Crooks PA, Gorrod JW. A HIGH‐PERFORMANCE LIQUID‐CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF IN VITRO METABOLITES OF METYRAPONE Journal of Pharmacy and Pharmacology. 31: 94P-94P. PMID 42774 DOI: 10.1111/j.2042-7158.1979.tb11642.x  0.96
1979 Deeks T, Crooks PA, Waigh RD. The synthesis and in vitro pharmacological evaluation of some novel enkephalin analogues Journal of Pharmacy and Pharmacology. 31. PMID 42739  0.96
1979 Deeks T, Crooks PA, Waigh RD. THE SYNTHESIS AND IN VITRO PHARMACOLOGICAL EVALUTION OF SOME NOVEL ENKEPHALIN ANALOGUES Journal of Pharmacy and Pharmacology. 31: 62P-62P. DOI: 10.1111/j.2042-7158.1979.tb11610.x  0.96
1979 Crooks PA, Rosenberg HE. Synthesis of 5-hydroxy- and 5,6-dihydroxy-derivatives of spiro[indane-2,2′-pyrrolidine], rigid analogues of tyramine and dopamine respectively Journal of the Chemical Society, Perkin Transactions 1. 2719-2726.  0.96
1978 Crooks PA, Rosenberg HE. Synthesis of spiro[tetralin-2,2′-pyrrolidine] and spiro[indan-2,2′-pyrrolidine] derivatives as potential analgesics Journal of Medicinal Chemistry. 21: 585-587. PMID 671457  0.96
1978 Burn PK, Crooks PA, Meth‐Cohn O. A carbon‐13 NMR study of benzonorbornene isomers Organic Magnetic Resonance. 11: 370-372. DOI: 10.1002/mrc.1270110710  0.96
1976 Crooks PA, Rosenberg HE. The synthesis and antinociceptive properties of spiro (indan -2, 2' pyrrolidine), spiro (tetralin -2, 2' pyrrolidine) and their N methyl derivatives Journal of Pharmacy and Pharmacology. 28. PMID 12363  0.96
1976 Burn P, Crooks PA, Rees JMH. Antinociceptive and sympathomimetic activities of exo- and endo- 2 aminobenzonorbornene and their N methylated derivatives Journal of Pharmacy and Pharmacology. 28. PMID 12360  0.96
1976 Crooks PA, Robinson B, Meth-Cohn O. The 13C-Nuclear Magnetic Resonance spectra of physostigmine and related compounds Phytochemistry. 15: 1092-1093. DOI: 10.1016/S0031-9422(00)84425-8  0.96
1974 Crooks PA, Collett JH, Withington R. The determination of the hydrophile hydrophobe proton ratio in a series of polyoxyethylene sorbitan esters Pharmaceutica Acta Helvetiae. 49: 274-276. PMID 4462134  0.96
1973 Crooks PA, Little HJ, Rees JM. Proceedings: The effects of amphetamine, 2-aminoindane and 2-aminotetralin on the concentrations of whole brain noradrenaline, dopamine, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the mouse. The Journal of Pharmacy and Pharmacology. 25: Suppl:124P. PMID 4150521  0.96
1973 CROOKS PA, ROBINSON B. Conopharyngine pseudoindoxyl, a new alkaloid from Tabernamontana pachysiphon Stapf, var cumminsii (Stapf.) H. Huber Journal of Pharmacy and Pharmacology. 25: 820-823. PMID 4149744 DOI: 10.1111/j.2042-7158.1973.tb09948.x  0.96
1973 Crooks PA, Szyndler R. Synthesis of β amino alcohols via spiro oxiran intermediates Chemistry and Industry (London). 1111-1112.  0.96
1968 Crooks PA, Robinson B, Smith GF. Isolation and structure of an indole alkaloid of biogenetic interest from Tabernamontana cummunii Chemical Communications (London). 1210. DOI: 10.1039/C19680001210  0.96
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