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Peter A. Crooks - Publications

Affiliations: 
1968-1981 Chemistry University of Manchester, Manchester, England, United Kingdom 
 1981-2011 University of Kentucky, Lexington, KY 
 2011- University of Arkansas for Medical Sciences, United States 
Area:
General Chemistry, Pharmacology, Pharmacy, Medicinal Chemistry
Website:
https://pharmacy.uams.edu/team/peter-crooks/
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Year Citation  Score
2020 Penthala NR, Shoeib A, Dachavaram SS, Cabanlong CV, Yang J, Zhan CG, Prather PL, Crooks PA. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & Medicinal Chemistry Letters. 30: 127501. PMID 32882418 DOI: 10.1016/J.Bmcl.2020.127501  0.312
2019 Lee NR, Zheng G, Leggas M, Janganati V, Nickell JR, Crooks PA, Bardo MT, Dwoskin L. GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine. The Journal of Pharmacology and Experimental Therapeutics. PMID 31413138 DOI: 10.1124/Jpet.119.258699  0.304
2019 Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of human DNA polymerases eta and kappa by indole-derived molecules occurs through distinct mechanisms. Acs Chemical Biology. PMID 31082191 DOI: 10.1021/Acschembio.9B00304  0.314
2019 Bommagani S, Penthala NR, Balasubramaniam M, Kuravi S, Caldas-Lopes E, Guzman ML, Balusu R, Crooks PA. A novel tetrazole analogue of resveratrol is a potent anticancer agent. Bioorganic & Medicinal Chemistry Letters. 29: 172-178. PMID 30528695 DOI: 10.1016/J.Bmcl.2018.12.006  0.383
2018 Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Crooks PA, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747  0.557
2018 Janganati V, Ponder J, Balasubramaniam M, Bhat-Nakshatri P, Bar EE, Nakshatri H, Jordan CT, Crooks PA. MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells. European Journal of Medicinal Chemistry. 157: 562-581. PMID 30121494 DOI: 10.1016/J.Ejmech.2018.08.010  0.344
2018 Lee NR, Zheng G, Crooks PA, Bardo MT, Dwoskin LP. New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders. The Aaps Journal. 20: 29. PMID 29427069 DOI: 10.1208/S12248-018-0192-Y  0.331
2018 Zafar MK, Maddukuri L, Ketkar A, Penthala N, Reed MR, Eddy SD, Crooks PA, Eoff RL. A small-molecule inhibitor of human DNA polymerase eta potentiates the effects of cisplatin in tumor cells. Biochemistry. PMID 29345908 DOI: 10.1021/Acs.Biochem.7B01176  0.319
2017 Hankosky ER, Joolakanti SR, Nickell JR, Janganati V, Dwoskin LP, Crooks PA. Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 29153425 DOI: 10.1016/J.Bmcl.2017.10.039  0.327
2017 Walbaum A, Fifer EK, Parkin S, Crooks PA. Crystal structure of 4,4'-bis-[3-(piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta Crystallographica. Section E, Crystallographic Communications. 73: 864-866. PMID 28638646 DOI: 10.1107/S2056989017007277  0.353
2017 Janganati V, Ponder J, Thakkar S, Jordan CT, Crooks PA. Succinamide derivatives of melampomagnolide B and their anti-cancer activities. Bioorganic & Medicinal Chemistry. PMID 28545815 DOI: 10.1016/J.Bmc.2017.05.008  0.366
2017 Bommagani S, Ponder J, Penthala NR, Janganati V, Jordan CT, Borrelli MJ, Crooks PA. Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells. European Journal of Medicinal Chemistry. 136: 393-405. PMID 28525840 DOI: 10.1016/J.Ejmech.2017.05.031  0.349
2017 Madadi NR, Penthala NR, Ketkar A, Eoff RL, Trujullo-Alonso V, Guzman ML, Crooks PA. Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer agents. Anti-Cancer Agents in Medicinal Chemistry. PMID 28403783 DOI: 10.2174/1871521409666170412115703  0.738
2016 Albayati ZA, Janganati V, Chen Z, Ponder J, Breen PJ, Jordan CT, Crooks PA. Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia. Bioorganic & Medicinal Chemistry. PMID 28049618 DOI: 10.1016/J.Bmc.2016.12.036  0.305
2016 Nickell JR, Siripurapu KB, Horton DB, Zheng G, Crooks PA, Dwoskin LP. GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2. European Journal of Pharmacology. 795: 143-149. PMID 27986625 DOI: 10.1016/J.Ejphar.2016.12.016  0.309
2016 Laxmi SV, Anil P, Rajitha G, Rao AJ, Crooks PA, Rajitha B. Synthesis of thiazolidine-2,4-dione derivatives: anticancer, antimicrobial and DNA cleavage studies. Journal of Chemical Biology. 9: 97-106. PMID 27698947 DOI: 10.1007/S12154-016-0154-8  0.33
2016 Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27524311 DOI: 10.1016/J.Bmcl.2016.08.001  0.32
2016 Penthala NR, Yadlapalli JK, Parkin S, Crooks PA. Crystal structures of (Z)-5-[2-(benzo[b]thio-phen-2-yl)-1-(3,5-di-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole and (Z)-5-[2-(benzo[b]thio-phen-3-yl)-1-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]-1H-tetra-zole. Acta Crystallographica. Section E, Crystallographic Communications. 72: 652-5. PMID 27308011 DOI: 10.1107/S2056989016005600  0.321
2016 Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. 1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27212067 DOI: 10.1016/J.Bmcl.2016.05.025  0.337
2016 Joolakanti SR, Nickell JR, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. PMID 27080180 DOI: 10.1016/J.Bmcl.2016.03.119  0.319
2016 Madadi NR, Ketkar A, Penthala NR, Bostian AC, Eoff RL, Crooks PA. Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells. Bioorganic & Medicinal Chemistry Letters. PMID 27017113 DOI: 10.1016/J.Bmcl.2016.03.068  0.73
2016 Penthala NR, Bommagani S, Yadlapalli J, Crooks PA. A novel and efficient tributyltin azide-mediated synthesis of 1H-tetrazolylstilbenes from cyanostilbenes Tetrahedron Letters. 57: 1807-1810. DOI: 10.1016/J.Tetlet.2016.03.040  0.331
2015 Penthala NR, Madhukuri L, Thakkar S, Madadi NR, Lamture G, Eoff RL, Crooks PA. Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents. Medchemcomm. 6: 1535-1543. PMID 27066215 DOI: 10.1039/C5Md00219B  0.744
2015 Penthala NR, Ketkar A, Sekhar KR, Freeman ML, Eoff RL, Balusu R, Crooks PA. 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1). Bioorganic & Medicinal Chemistry. PMID 26602084 DOI: 10.1016/J.Bmc.2015.10.019  0.348
2015 Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison crystal structure conformations of two structurally related biphenyl analogues: 4,4'-bis-[3-(pyrrolidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-{3-[(S)-2-methyl-pyrrolidin-1-yl]prop-1-yn-1-yl}-1,1'-biphen-yl. Acta Crystallographica. Section E, Crystallographic Communications. 71: 1147-50. PMID 26594393 DOI: 10.1107/S2056989015016163  0.336
2015 Wan A, Penthala NR, Fifer EK, Parkin S, Crooks PA. Comparison of the crystal structures of 4,4'-bis-[3-(4-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphenyl and 4,4'-bis-[3-(2,2,6,6-tetra-methyl-piperidin-1-yl)prop-1-yn-1-yl]-1,1'-biphen-yl. Acta Crystallographica. Section E, Crystallographic Communications. 71: 1132-5. PMID 26594389 DOI: 10.1107/S2056989015015352  0.334
2015 Crooks PA, Janganati V, Ponder J, Jordan CT, Borrelli MJ, Penthala NR. Dimers of melampomagnolide B exhibit potent anticancer activity against hematological and solid tumor cells. Journal of Medicinal Chemistry. PMID 26540463 DOI: 10.1021/Acs.Jmedchem.5B01187  0.34
2015 Madadi NR, Penthala NR, Howk K, Ketkar A, Eoff RL, Borrelli MJ, Crooks PA. Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4. European Journal of Medicinal Chemistry. 103: 123-32. PMID 26352674 DOI: 10.1016/J.Ejmech.2015.08.041  0.747
2015 Madadi NR, Zong H, Ketkar A, Zheng C, Penthala NR, Janganati V, Bommagani S, Eoff RL, Guzman ML, Crooks PA. Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin. Medchemcomm. 6: 788-794. PMID 26257861 DOI: 10.1039/C4Md00478G  0.73
2015 Beckmann JS, Meyer AC, Pivavarchyk M, Horton DB, Zheng G, Smith AM, Wooters TE, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement. Neurochemical Research. PMID 26227997 DOI: 10.1007/S11064-015-1680-4  0.318
2015 Penthala NR, Thakkar S, Crooks PA. Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 25: 2763-7. PMID 26022840 DOI: 10.1016/J.Bmcl.2015.05.019  0.343
2015 Ding D, Nickell JR, Dwoskin LP, Crooks PA. Quinolyl analogues of norlobelane: Novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. 25: 2613-6. PMID 25991431 DOI: 10.1016/J.Bmcl.2015.04.105  0.333
2015 Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA. Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents. European Journal of Medicinal Chemistry. 92: 212-20. PMID 25557492 DOI: 10.1016/J.Ejmech.2014.12.050  0.738
2015 Gali R, Banothu J, Gondru R, Bavantula R, Velivela Y, Crooks PA. One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies. Bioorganic & Medicinal Chemistry Letters. 25: 106-12. PMID 25435148 DOI: 10.1016/J.Bmcl.2014.10.100  0.336
2015 Penthala NR, Madhukuri L, Thakkar S, Madadi NR, Lamture G, Eoff RL, Crooks PA. Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents Medchemcomm. 6: 1535-1543. DOI: 10.1039/c5md00219b  0.694
2015 Penthala NR, Madadi NR, Janganati V, Crooks PA. ChemInform Abstract: L-Proline Catalyzed One-Step Synthesis of 4,5-Diaryl-2H-1,2,3-triazoles from Heteroaryl Cyanostilbenes via [3 + 2]Cycloaddition of Azide. Cheminform. 46: no-no. DOI: 10.1002/CHIN.201511180  0.703
2015 Madadi NR, Crooks PA. Anticancer Evaluation of 3,4,5,4'-trans-tetramethoxystilbene (DMU-212) and Its Analogs Against an Extensive Panel of Human Tumor Cell Lines Letters in Drug Design and Discovery. 12: 521-528.  0.704
2014 Penthala NR, Madadi NR, Bommagani S, Parkin S, Crooks PA. Comparison of crystal structures of 4-(benzo[b]thio-phen-2-yl)-5-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole and 4-(benzo[b]thio-phen-2-yl)-2-methyl-5-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole. Acta Crystallographica. Section E, Structure Reports Online. 70: 392-5. PMID 25484755 DOI: 10.1107/S1600536814023095  0.731
2014 Madadi NR, Penthala NR, Bommagani S, Parkin S, Crooks PA. Crystal structure of 4,5-bis-(3,4,5-tri-meth-oxy-phen-yl)-2H-1,2,3-triazole methanol monosolvate. Acta Crystallographica. Section E, Structure Reports Online. 70: o1128-9. PMID 25484710 DOI: 10.1107/S1600536814020911  0.727
2014 Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA. Crystal structure of (E)-13-{4-[(Z)-2-cyano-2-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]phen-yl}parthenolide methanol hemisolvate. Acta Crystallographica. Section E, Structure Reports Online. 70: o1092-3. PMID 25484689 DOI: 10.1107/S1600536814019333  0.342
2014 Penthala NR, Madadi NR, Janganati V, Crooks PA. L-Proline catalyzed one-step synthesis of 4,5-diaryl-2H-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2] cycloaddition of azide. Tetrahedron Letters. 55: 5562-5565. PMID 25267862 DOI: 10.1016/J.Tetlet.2014.08.027  0.728
2014 Penthala NR, Bommagani S, Janganati V, MacNicol KB, Cragle CE, Madadi NR, Hardy LL, MacNicol AM, Crooks PA. Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression. European Journal of Medicinal Chemistry. 85: 517-25. PMID 25117652 DOI: 10.1016/J.Ejmech.2014.08.022  0.733
2014 Janganati V, Penthala NR, Madadi NR, Chen Z, Crooks PA. Anti-cancer activity of carbamate derivatives of melampomagnolide B. Bioorganic & Medicinal Chemistry Letters. 24: 3499-502. PMID 24928404 DOI: 10.1016/J.Bmcl.2014.05.059  0.726
2014 Franks LN, Ford BM, Madadi NR, Penthala NR, Crooks PA, Prather PL. Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs. European Journal of Pharmacology. 737: 140-8. PMID 24858620 DOI: 10.1016/J.Ejphar.2014.05.007  0.716
2014 Janganati V, Penthala NR, Madadi NR, Parkin S, Crooks PA. Monosuccinate ester of melampomagnolide B. Acta Crystallographica. Section E, Structure Reports Online. 70: o372-3. PMID 24765054 DOI: 10.1107/S1600536814002815  0.716
2014 Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA. (E)-13-(2-Bromo-phen-yl)micheliolide. Acta Crystallographica. Section E, Structure Reports Online. 70: o251-2. PMID 24764970 DOI: 10.1107/S1600536814002177  0.317
2014 Janganati V, Penthala NR, Cragle CE, MacNicol AM, Crooks PA. Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation. Bioorganic & Medicinal Chemistry Letters. 24: 1963-7. PMID 24656611 DOI: 10.1016/J.Bmcl.2014.02.067  0.301
2014 Greer AK, Madadi NR, Bratton SM, Eddy SD, Mazerska Z, Hendrickson HP, Crooks PA, Radominska-Pandya A. Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases. Chemical Research in Toxicology. 27: 536-45. PMID 24571610 DOI: 10.1021/Tx400408X  0.722
2014 Crooks PA, Bardo MT, Dwoskin LP. Nicotinic receptor antagonists as treatments for nicotine abuse. Advances in Pharmacology (San Diego, Calif.). 69: 513-51. PMID 24484986 DOI: 10.1016/B978-0-12-420118-7.00013-5  0.303
2014 Madadi NR, Penthala NR, Janganati V, Crooks PA. Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines. Bioorganic & Medicinal Chemistry Letters. 24: 601-3. PMID 24361000 DOI: 10.1016/J.Bmcl.2013.12.013  0.753
2014 Penthala NR, Janganati V, Bommagani S, Crooks PA. Synthesis and evaluation of a series of quinolinyl trans-cyanostilbene analogs as anticancer agents Med. Chem. Commun.. 5: 886-890. DOI: 10.1039/C4Md00115J  0.317
2014 Madadi NR, Penthala NR, Song L, Hendrickson HP, Crooks PA. Preparation of 4,5 disubstituted-2H-1,2,3-triazoles from (Z)-2,3-diaryl substituted acrylonitriles Tetrahedron Letters. 55: 4207-4211. DOI: 10.1016/J.Tetlet.2014.05.045  0.722
2014 Madadi NR, Penthala NR, Song L, Hendrickson HP, Crooks PA. ChemInform Abstract: Preparation of 4,5-Disubstituted-2H-1,2,3-triazoles from (Z)-2,3-Diaryl Substituted Acrylonitriles. Cheminform. 45: no-no. DOI: 10.1002/CHIN.201452135  0.705
2013 Bommagani S, Penthala NR, Janganati V, Parkin S, Crooks PA. 13-(N,N-Di-methyl-amino)-micheliolide 0.08-hydrate. Acta Crystallographica. Section E, Structure Reports Online. 69: o1789-90. PMID 24454230 DOI: 10.1107/S1600536813030304  0.323
2013 Janganati V, Penthala NR, Parkin S, Crooks PA. 13-(Imidazol-1-yl)-11,13-di-hydro-melampomagnolide B monohydrate. Acta Crystallographica. Section E, Structure Reports Online. 69: o1734-5. PMID 24454194 DOI: 10.1107/S1600536813029188  0.321
2013 Penthala NR, Janganati V, Parkin S, Varughese KI, Crooks PA. (E)-13-(4-Amino-phen-yl)parthenolide. Acta Crystallographica. Section E, Structure Reports Online. 69: o1709-10. PMID 24454134 DOI: 10.1107/S1600536813028730  0.327
2013 Ding D, Nickell JR, Deaciuc AG, Penthala NR, Dwoskin LP, Crooks PA. Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake. Bioorganic & Medicinal Chemistry. 21: 6771-7. PMID 23993667 DOI: 10.1016/J.Bmc.2013.08.001  0.329
2013 Penthala NR, Sonar VN, Horn J, Leggas M, Yadlapalli JS, Crooks PA. Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents. Medchemcomm. 4: 1073-1078. PMID 23956835 DOI: 10.1039/C3Md00130J  0.322
2013 Coggins GE, Maddukuri L, Penthala NR, Hartman JH, Eddy S, Ketkar A, Crooks PA, Eoff RL. N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases. Acs Chemical Biology. 8: 1722-9. PMID 23679919 DOI: 10.1021/Cb400305R  0.321
2013 Penthala NR, Ponugoti PR, Nickell JR, Deaciuc AG, Dwoskin LP, Crooks PA. Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2). Bioorganic & Medicinal Chemistry Letters. 23: 3342-5. PMID 23597792 DOI: 10.1016/J.Bmcl.2013.03.092  0.321
2013 Zheng G, Horton DB, Penthala NR, Nickell JR, Culver JP, Deaciuc AG, Dwoskin LP, Crooks PA. Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse. Medchemcomm. 4: 564-568. PMID 23527317 DOI: 10.1039/C3Md20374C  0.351
2013 Madadi NR, Penthala NR, Brents LK, Ford BM, Prather PL, Crooks PA. Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors. Bioorganic & Medicinal Chemistry Letters. 23: 2019-21. PMID 23466226 DOI: 10.1016/J.Bmcl.2013.02.025  0.729
2013 Ring JR, Zheng F, Haubner AJ, Littleton JM, Crooks PA. Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study. Bioorganic & Medicinal Chemistry. 21: 1764-74. PMID 23465801 DOI: 10.1016/J.Bmc.2013.01.051  0.774
2013 Penthala NR, Crooks PA. rac-N-Benzyl-isatincreatinine (unknown solvate). Acta Crystallographica. Section E, Structure Reports Online. 69: o290-1. PMID 23424560 DOI: 10.1107/S1600536813000378  0.332
2013 Penthala NR, Crooks PA. rac-5-Bromo-N-benzyl-isatincreatinine ethanol monosolvate. Acta Crystallographica. Section E, Structure Reports Online. 69: o288-9. PMID 23424559 DOI: 10.1107/S160053681300038X  0.321
2013 Penthala NR, Ponugoti PR, Kasam V, Crooks PA. 5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties. Bioorganic & Medicinal Chemistry Letters. 23: 1442-6. PMID 23339966 DOI: 10.1016/J.Bmcl.2012.12.053  0.364
2013 Penthala NR, Yerramreddy TR, Parkin S, Crooks PA. Solvent-Specific C―N Bond Formation: Synthesis of Novel Ninhydrin-Creatinine Heterocyclic Condensation Products Journal of Heterocyclic Chemistry. 50: E156-E159. DOI: 10.1002/Jhet.1107  0.347
2012 Penthala NR, Ponugoti PR, Parkin S, Crooks PA. rac-(Z)-Methyl 1-benzyl-3-[(3-hy-droxy-quinuclidin-2-yl-idene)meth-yl]-1H-indole-6-carboxyl-ate. Acta Crystallographica. Section E, Structure Reports Online. 68: o3111. PMID 23284437 DOI: 10.1107/S1600536812040731  0.339
2012 Sonar VN, Parkin S, Crooks PA. Oxycodone N-oxide. Acta Crystallographica. Section C, Crystal Structure Communications. 68: o436-8. PMID 23124457 DOI: 10.1107/S0108270112040188  0.315
2012 Sonar VN, Parkin S, Crooks PA. The effect of hydrogen bonding on the conformations of 2-(1H-indol-3-yl)-2-oxoacetamide and 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide. Acta Crystallographica. Section C, Crystal Structure Communications. 68: o405-7. PMID 23007543 DOI: 10.1107/S0108270112038322  0.315
2012 Barron S, Lewis B, Wellmann K, Carter M, Farook J, Ring J, Rogers DT, Holley R, Crooks P, Littleton J. Polyamine modulation of NMDARs as a mechanism to reduce effects of alcohol dependence. Recent Patents On Cns Drug Discovery. 7: 129-44. PMID 22574674 DOI: 10.2174/157488912800673128  0.312
2012 Penthala NR, Parkin S, Crooks PA. (Z)-3-(1-Benzofuran-2-yl)-2-(3,4,5-tri-meth-oxy-phen-yl)acrylonitrile. Acta Crystallographica. Section E, Structure Reports Online. 68: o731. PMID 22412613 DOI: 10.1107/S1600536812005831  0.31
2012 Madadi NR, Parkin S, Crooks PA. (Z)-2-{2,4-Dimeth-oxy-6-[(E)-4-meth-oxy-styr-yl]benzyl-idene}quinuclidin-3-one. Acta Crystallographica. Section E, Structure Reports Online. 68: o730. PMID 22412612 DOI: 10.1107/S1600536812005843  0.726
2012 Penthala NR, Parkin S, Crooks PA. (Z)-3-(1H-Indol-3-yl)-2-(3,4,5-tri-methoxy-phen-yl)acrylonitrile. Acta Crystallographica. Section E, Structure Reports Online. 68: o729. PMID 22412611 DOI: 10.1107/S1600536812005855  0.33
2011 Zhang Z, Dwoskin LP, Crooks PA. Expeditious synthesis of cis-1-methyl-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo-[3,2h]isoquinoline / [2,3-f]quinoline via azomethine ylide-alkene [3+2] cycloaddition. Tetrahedron Letters. 52: 2667-2669. PMID 23908558 DOI: 10.1016/J.Tetlet.2011.03.065  0.314
2011 Horton DB, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. The Journal of Pharmacology and Experimental Therapeutics. 339: 286-97. PMID 21778282 DOI: 10.1124/Jpet.111.184770  0.344
2011 Nasim S, Guzman ML, Jordan CT, Crooks PA. Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture. Bioorganic & Medicinal Chemistry Letters. 21: 4879-83. PMID 21757349 DOI: 10.1016/J.Bmcl.2011.06.027  0.309
2011 Biermann M, Hardcastle KI, Moskalev NV, Crooks PA. (S)-2-Amino-2-(2-chloro-phen-yl)cyclo-hexa-none. Acta Crystallographica. Section E, Structure Reports Online. 67: o936. PMID 21754205 DOI: 10.1107/S1600536811009950  0.323
2011 Ponugoti PR, Penthala NR, Dwoskin LP, Parkin S, Crooks PA. cis-1-Benzyl-pyrrolidine-2,5-dicarbonitrile. Acta Crystallographica. Section E, Structure Reports Online. 67: o747. PMID 21754044 DOI: 10.1107/S1600536811006258  0.323
2011 Vijaya Laxmi S, Thirupathi Reddy Y, Suresh Kuarm B, Narsimha Reddy P, Crooks PA, Rajitha B. Synthesis and evaluation of chromenyl barbiturates and thiobarbiturates as potential antitubercular agents. Bioorganic & Medicinal Chemistry Letters. 21: 4329-31. PMID 21684158 DOI: 10.1016/J.Bmcl.2011.05.055  0.323
2011 Ponugoti PR, Penthala NR, Dwoskin LP, Parkin S, Crooks PA. cis-2,5-Bis(2-fluoro-5-meth-oxy-pheneth-yl)pyrrolidinium formate. Acta Crystallographica. Section E, Structure Reports Online. 67: o737. PMID 21522476 DOI: 10.1107/S1600536811006143  0.327
2011 Hojahmat M, Zheng G, Siegler M, Parkin S, Biermann M, Crooks PA. (S)-1-(2-Chloro-phen-yl)-2-oxocyclo-hexan-1-aminium d-tartrate. Acta Crystallographica. Section E, Structure Reports Online. 67: o736. PMID 21522475 DOI: 10.1107/S1600536811006131  0.323
2011 Penthala NR, Reddy TR, Parkin S, Crooks PA. (2Z,3E)-2-{[1-(4-Chloro-benz-yl)-1H-indol-3-yl]methyl-idene}quinuclidin-3-one oxime. Acta Crystallographica. Section E, Structure Reports Online. 67: o735. PMID 21522474 DOI: 10.1107/S160053681100612X  0.351
2011 Pivavarchyk M, Smith AM, Zhang Z, Zhou D, Wang X, Toyooka N, Tsuneki H, Sasaoka T, McIntosh JM, Crooks PA, Dwoskin LP. Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release. European Journal of Pharmacology. 658: 132-9. PMID 21371454 DOI: 10.1016/J.Ejphar.2011.02.018  0.333
2011 Penthala NR, Yerramreddy TR, Crooks PA. Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters. 21: 1411-3. PMID 21295476 DOI: 10.1016/J.Bmcl.2011.01.020  0.381
2011 Wooters TE, Smith AM, Pivavarchyk M, Siripurapu KB, McIntosh JM, Zhang Z, Crooks PA, Bardo MT, Dwoskin LP. bPiDI: a novel selective α6β2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse. British Journal of Pharmacology. 163: 346-57. PMID 21232049 DOI: 10.1111/J.1476-5381.2011.01220.X  0.314
2011 Horton DB, Siripurapu KB, Norrholm SD, Culver JP, Hojahmat M, Beckmann JS, Harrod SB, Deaciuc AG, Bardo MT, Crooks PA, Dwoskin LP. meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release. The Journal of Pharmacology and Experimental Therapeutics. 336: 940-51. PMID 21177475 DOI: 10.1124/Jpet.110.175117  0.302
2011 Zhang Z, Zheng G, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 21: 88-91. PMID 21147530 DOI: 10.1016/J.Bmcl.2010.11.070  0.321
2011 Kuarm BS, Reddy YT, Madhav JV, Crooks PA, Rajitha B. 3-[Benzimidazo- and 3-[benzothiadiazoleimidazo-(1,2-c)quinazolin-5-yl]-2H-chromene-2-ones as potent antimicrobial agents. Bioorganic & Medicinal Chemistry Letters. 21: 524-7. PMID 21134751 DOI: 10.1016/J.Bmcl.2010.10.082  0.304
2011 Crooks PA, Zheng G, Vartak AP, Culver JP, Zheng F, Horton DB, Dwoskin LP. Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse. Current Topics in Medicinal Chemistry. 11: 1103-27. PMID 21050177 DOI: 10.2174/156802611795371332  0.305
2011 Nickell JR, Zheng G, Deaciuc AG, Crooks PA, Dwoskin LP. Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2. The Journal of Pharmacology and Experimental Therapeutics. 336: 724-33. PMID 20876747 DOI: 10.1124/Jpet.110.172882  0.356
2011 Shanmugam R, Kusumanchi P, Appaiah H, Cheng L, Crooks P, Neelakantan S, Peat T, Klaunig J, Matthews W, Nakshatri H, Sweeney CJ. A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species. International Journal of Cancer. Journal International Du Cancer. 128: 2481-94. PMID 20669221 DOI: 10.1002/Ijc.25587  0.305
2011 Zong H, Penthala NR, Sen S, Brennan S, Sonar V, Crooks PA, Guzman ML. The Acrylonitrile Analog, VJ-289 Ablates Acute Myelogenous Leukemia Blast, Progenitor and Stem Cell Populations by Inducing Tubulin Acetylation and Caspase Activation Blood. 118: 2496-2496. DOI: 10.1182/Blood.V118.21.2496.2496  0.307
2011 Leggas M, Tsakalozou E, Ahmed T, Kuo K, Horn J, Penthala N, Crooks P. Abstract C216: Small molecule antitubulin drugs that evade multiple drug resistance mechanisms. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C216  0.305
2010 Penthala NR, Eldridge J, Reddy TR, Parkin S, Crooks PA. (E,E)-1-Methyl-2,6-distyrylpyridinium iodide. Acta Crystallographica. Section E, Structure Reports Online. 66: o1793. PMID 21588003 DOI: 10.1107/S1600536810018519  0.331
2010 Madadi NR, Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-2-Amino-5-[2,4-dimeth-oxy-6-(4-methoxy-styr-yl)benzyl-idene]-1,3-thia-zol-4(5H)-one methanol solvate. Acta Crystallographica. Section E, Structure Reports Online. 66: o1792. PMID 21588002 DOI: 10.1107/S1600536810018520  0.73
2010 Venkateswaran A, Reddy YT, Sonar VN, Muthusamy V, Crooks PA, Freeman ML, Sekhar KR. Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives. Bioorganic & Medicinal Chemistry Letters. 20: 7323-6. PMID 21055930 DOI: 10.1016/J.Bmcl.2010.10.060  0.349
2010 Beckmann JS, Siripurapu KB, Nickell JR, Horton DB, Denehy ED, Vartak A, Crooks PA, Dwoskin LP, Bardo MT. The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats. The Journal of Pharmacology and Experimental Therapeutics. 335: 841-51. PMID 20805303 DOI: 10.1124/Jpet.110.172742  0.326
2010 Penthala NR, Yerramreddy TR, Madadi NR, Crooks PA. Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters. 20: 4468-71. PMID 20598531 DOI: 10.1016/J.Bmcl.2010.06.042  0.741
2010 Thirupathi Reddy Y, Narsimha Reddy P, Koduru S, Damodaran C, Crooks PA. Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones. Bioorganic & Medicinal Chemistry. 18: 3570-4. PMID 20403701 DOI: 10.1016/J.Bmc.2010.03.054  0.359
2010 Smith AM, Pivavarchyk M, Wooters TE, Zhang Z, Zheng G, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release. Biochemical Pharmacology. 80: 402-9. PMID 20346923 DOI: 10.1016/J.Bcp.2010.03.018  0.307
2010 Zhang Z, Pivavarchyk M, Subramanian KL, Deaciuc AG, Dwoskin LP, Crooks PA. Novel bis-2,2,6,6-tetramethylpiperidine (bis-TMP) and bis-mecamylamine antagonists at neuronal nicotinic receptors mediating nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 20: 1420-3. PMID 20079634 DOI: 10.1016/J.Bmcl.2009.12.089  0.339
2010 Geldenhuys WJ, Manda VK, Mittapalli RK, Van der Schyf CJ, Crooks PA, Dwoskin LP, Allen DD, Lockman PR. Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry Letters. 20: 870-7. PMID 20053562 DOI: 10.1016/J.Bmcl.2009.12.079  0.303
2010 Hojahmat M, Horton DB, Norrholm SD, Miller DK, Grinevich VP, Deaciuc AG, Dwoskin LP, Crooks PA. Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorganic & Medicinal Chemistry. 18: 640-9. PMID 20036131 DOI: 10.1016/J.Bmc.2009.12.002  0.307
2010 Penthala NR, Yerramreddy TR, Crooks PA. Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines. Bioorganic & Medicinal Chemistry Letters. 20: 591-3. PMID 20006496 DOI: 10.1016/J.Bmcl.2009.11.083  0.38
2010 Reddy YT, Sekhar KR, Sasi N, Reddy PN, Freeman ML, Crooks PA. Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents Bioorganic and Medicinal Chemistry Letters. 20: 600-602. PMID 20005706 DOI: 10.1016/J.Bmcl.2009.11.082  0.352
2010 Bence AK, Crooks PA. ChemInform Abstract: Synthesis of L-Indospicine. Cheminform. 33: no-no. DOI: 10.1002/chin.200248191  0.716
2009 Penthala NR, Reddy TR, Parkin S, Crooks PA. rac-2-(2-Amino-4-oxo-4,5-dihydro-1,3-thia-zol-5-yl)-2-hydroxy-indane-1,3-dione. Acta Crystallographica. Section E, Structure Reports Online. 65: o1877. PMID 21583571 DOI: 10.1107/S1600536809025574  0.33
2009 Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-3-hydroxy-indolin-2-one monohydrate. Acta Crystallographica. Section E, Structure Reports Online. 65: o552. PMID 21582211 DOI: 10.1107/S1600536809004875  0.344
2009 Zheng G, Parkin S, Dwoskin LP, Crooks PA. (2S,6S)-1-Methyl-2,6-trans-distyryl-piperidinium chloride. Acta Crystallographica. Section E, Structure Reports Online. 66: o78. PMID 21580177 DOI: 10.1107/S1600536809049587  0.331
2009 Zheng G, Parkin S, Dwoskin LP, Crooks PA. 1-Methyl-2,6-cis-distyrylpiperidine. Acta Crystallographica. Section E, Structure Reports Online. 66: o77. PMID 21580176 DOI: 10.1107/S1600536809049617  0.326
2009 Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-5-fluoro-3-hydr-oxy-1-methyl-indolin-2-one methanol hemisolvate. Acta Crystallographica. Section E, Structure Reports Online. 65: o2909-10. PMID 21578489 DOI: 10.1107/S1600536809043797  0.323
2009 Penthala NR, Reddy TR, Parkin S, Crooks PA. 3-(2-Amino-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl)-3-hydr-oxy-1-phenyl-indolin-2-one ethanol solvate. Acta Crystallographica. Section E, Structure Reports Online. 65: o2439-40. PMID 21577895 DOI: 10.1107/S1600536809033881  0.353
2009 Worthen DR, Bence AK, Stables JP, Crooks PA. In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity. Bioorganic & Medicinal Chemistry Letters. 19: 5012-5. PMID 19632831 DOI: 10.1016/J.Bmcl.2009.07.059  0.741
2009 Smith AM, Dhawan GK, Zhang Z, Siripurapu KB, Crooks PA, Dwoskin LP. The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices. Biochemical Pharmacology. 78: 889-97. PMID 19631612 DOI: 10.1016/J.Bcp.2009.07.010  0.315
2009 López-Hernández GY, Thinschmidt JS, Zheng G, Zhang Z, Crooks PA, Dwoskin LP, Papke RL. Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists. Molecular Pharmacology. 76: 652-66. PMID 19556356 DOI: 10.1124/Mol.109.056176  0.317
2009 Neelakantan S, Nasim S, Guzman ML, Jordan CT, Crooks PA. Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1). Bioorganic & Medicinal Chemistry Letters. 19: 4346-9. PMID 19505822 DOI: 10.1016/J.Bmcl.2009.05.092  0.328
2009 Zheng F, McConnell MJ, Zhan CG, Dwoskin LP, Crooks PA. QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum. Bioorganic & Medicinal Chemistry. 17: 4477-85. PMID 19477134 DOI: 10.1016/J.Bmc.2009.05.010  0.325
2009 Zheng F, Zheng G, Deaciuc AG, Zhan CG, Dwoskin LP, Crooks PA. Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor. Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 157-68. PMID 18629679 DOI: 10.1080/14756360801945648  0.312
2009 Sonar VN, Crooks PA. Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 117-124. PMID 18629678 DOI: 10.1080/14756360801915526  0.329
2009 Hassane D, Sen S, Corbett CA, Balys M, Rossi RM, Crooks PA, Guzman ML, Jordan CT. Chemical Genomic Screening Reveals That PI3K/mTOR Inhibition Enhances Activity of the Anti-Leukemia Stem Cell Compound Parthenolide. Blood. 114: 388-388. DOI: 10.1182/Blood.V114.22.388.388  0.321
2009 Guzman ML, Nasim S, Balys M, Corbett CA, Crooks PA, Jordan CT. Chemical Derivatives of the Anti-Leukemia Stem Cell Compound 4-Benzyl-2-Methyl-1,2,4-Thiadiazolidine-3,5-Dione (TDZD-8) with Improved Activity. Blood. 114: 3764-3764. DOI: 10.1182/Blood.V114.22.3764.3764  0.341
2009 Pei S, Guzman ML, Nasim S, Shi L, Crooks PA, Jordan CT. Analysis of the Anti-Leukemia Mechanism of Parthenolide. Blood. 114: 2734-2734. DOI: 10.1182/Blood.V114.22.2734.2734  0.319
2008 Penthala NR, Reddy TR, Parkin S, Crooks PA. (Z)-Methyl 4-({3-[(2,5-dioxoimidazolidin-4-yl-idene)meth-yl]-1H-indol-1-yl}meth-yl)benzoate. Acta Crystallographica. Section E, Structure Reports Online. 65: o62-3. PMID 21581703 DOI: 10.1107/S1600536808041020  0.329
2008 Penthala NR, Reddy TR, Parkin S, Crooks PA. (Z)-4-[3-(2,5-Dioxoimidazolidin-4-ylidenemeth-yl)-1H-indol-1-ylmeth-yl]benzonitrile. Acta Crystallographica. Section E, Structure Reports Online. 64: o2122. PMID 21580984 DOI: 10.1107/S1600536808032601  0.343
2008 Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-Methyl 4-[3-(3-oxoquinuclidin-2-yl-idenemeth-yl)-1H-indol-1-ylmeth-yl]benzoate. Acta Crystallographica. Section E, Structure Reports Online. 64: o2050. PMID 21580918 DOI: 10.1107/S1600536808030018  0.356
2008 Reddy TR, Penthala NR, Parkin S, Crooks PA. (Z)-4-[3-(3-Oxoquinuclidin-2-ylidene-meth-yl)-1H-indol-1-ylmeth-yl]benzo-nitrile. Acta Crystallographica. Section E, Structure Reports Online. 64: o2049. PMID 21580917 DOI: 10.1107/S1600536808030006  0.349
2008 Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry Letters. 18: 6509-12. PMID 18976906 DOI: 10.1016/J.Bmcl.2008.10.042  0.325
2008 Zhang Z, Zheng G, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 18: 5753-7. PMID 18851914 DOI: 10.1016/J.Bmcl.2008.09.084  0.323
2008 Zhang Z, Lockman PR, Mittapalli RK, Allen DD, Dwoskin LP, Crooks PA. bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry Letters. 18: 5622-5. PMID 18793853 DOI: 10.1016/J.Bmcl.2008.08.099  0.323
2008 Nasim S, Crooks PA. Antileukemic activity of aminoparthenolide analogs Bioorganic and Medicinal Chemistry Letters. 18: 3870-3873. PMID 18590961 DOI: 10.1016/J.Bmcl.2008.06.050  0.331
2008 Dwoskin LP, Wooters TE, Sumithran SP, Siripurapu KB, Joyce BM, Lockman PR, Manda VK, Ayers JT, Zhang Z, Deaciuc AG, McIntosh JM, Crooks PA, Bardo MT. N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity. The Journal of Pharmacology and Experimental Therapeutics. 326: 563-76. PMID 18460644 DOI: 10.1124/Jpet.108.136630  0.33
2008 Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, Deo N, Day CS, Caldwell WS. Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands. The Journal of Organic Chemistry. 73: 3497-507. PMID 18363376 DOI: 10.1021/Jo800028Q  0.356
2008 Lockman PR, Manda VK, Geldenhuys WJ, Mittapalli RK, Thomas F, Albayati ZF, Crooks PA, Dwoskin LP, Allen DD. Carrier-mediated transport of the quaternary ammonium neuronal nicotinic receptor antagonist n,n'-dodecylbispicolinium dibromide at the blood-brain barrier. The Journal of Pharmacology and Experimental Therapeutics. 324: 244-50. PMID 17921191 DOI: 10.1124/Jpet.107.130906  0.332
2008 Reddy YT, Reddy PN, Crooks PA, De Clercq E, Rao GVP, Rajitha B. SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SUBSTITUTED N1-[1-BENZYL-3-(3-TERT-BUTYLCARBAMOYL-OCTAHYDROISOQUINOLIN-2YL)-2-HYDROXY- PROPYL]-2-[(2-OXO-2H-CHROMENE-3-CARBONYL) AMINO] SUCCINAMIDE ANALOGS AS ΑΝΤΙ-VIRAL AND ΑΝΤΙ-HIV AGENTS Heterocyclic Communications. 14. DOI: 10.1515/Hc.2008.14.6.419  0.315
2007 Zheng G, Zhang Z, Pivavarchyk M, Deaciuc AG, Dwoskin LP, Crooks PA. Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation. Bioorganic & Medicinal Chemistry Letters. 17: 6734-8. PMID 18029180 DOI: 10.1016/J.Bmcl.2007.10.052  0.326
2007 Sonar VN, Thirupathi Reddy Y, Sekhar KR, Sasi S, Freeman ML, Crooks PA. Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents Bioorganic and Medicinal Chemistry Letters. 17: 6821-6824. PMID 17980582 DOI: 10.1016/J.Bmcl.2007.10.035  0.331
2007 Zheng G, Sumithran SP, Deaciuc AG, Dwoskin LP, Crooks PA. Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 17: 6701-6. PMID 17977723 DOI: 10.1016/J.Bmcl.2007.10.062  0.331
2007 Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, Hassane DC, Becker MW, Bennett JM, Sullivan E, Lachowicz JL, Vaughan A, Sweeney CJ, Matthews W, Carroll M, Liesveld JL, ... Crooks PA, et al. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood. 110: 4427-35. PMID 17804695 DOI: 10.1182/Blood-2007-05-090621  0.309
2007 Dwoskin LP, Joyce BM, Zheng G, Neugebauer NM, Manda VK, Lockman P, Papke RL, Bardo MT, Crooks PA. Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD). Biochemical Pharmacology. 74: 1271-82. PMID 17727820 DOI: 10.1016/J.Bcp.2007.07.021  0.329
2007 Sonar VN, Venkatraj M, Parkin S, Crooks PA. rac-(Z)-2-(2-Thienylmethylene)-1-azabicyclo[2.2.2]octan-3-ol. Acta Crystallographica. Section C, Crystal Structure Communications. 63: o493-5. PMID 17675705 DOI: 10.1107/S0108270107033690  0.31
2007 Ring JR, Parkin S, Crooks PA. (4-Meth-oxy-3-nitro-benzyl-idene-amino)-guanidinium chloride Acta Crystallographica Section C: Crystal Structure Communications. 63. PMID 17609569 DOI: 10.1107/S0108270107023475  0.304
2007 Sonar VN, Venkatraj M, Parkin S, Crooks PA. (Z)-2-[(1-Phenylsulfonyl-1H-indol-3-yl)methylene]-1-azabicyclo[2.2.2]octan-3-one semicarbazone. Acta Crystallographica. Section C, Crystal Structure Communications. 63: o277-9. PMID 17478911 DOI: 10.1107/S0108270107006129  0.326
2007 Sonar VN, Parkin S, Crooks PA. (Z)-2-(1-Benzyl-5-nitro-1H-indol-3-ylmethyl-ene)-1-aza-bicyclo-[2.2.2] octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 63. PMID 17284808 DOI: 10.1107/S0108270106055971  0.322
2007 Middleton LS, Crooks PA, Wedlund PJ, Cass WA, Dwoskin LP. Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation. Synapse (New York, N.Y.). 61: 157-65. PMID 17146768 DOI: 10.1002/Syn.20351  0.3
2007 Nasim S, Parkin S, Crooks PA. (11R)-13-(1-Naphthylmethylamino)-4,5-epoxy-11,13-dihydrocostunolide Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807046983  0.321
2007 Sonar VN, Parkin S, Crooks PA. (Z)-3-[1-(4-Chloro-benz-yl)-1H-indol-3-yl]-2-(3-thien-yl)acrylonitrile Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807042638  0.332
2007 Sonar VN, Parkin S, Crooks PA. Rac-(Z)-2-(1-Naphthyl-methyl-ene)-1-aza-bicyclo-[2.2.2]octan-3-ol Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807041682  0.309
2007 Sonar VN, Parkin S, Crooks PA. Rac-(Z)-2-(2,4-Dichloro-benzyl-idene)-1-aza-bicyclo-[2.2.2]octan-3-ol Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807041128  0.306
2007 Sonar VN, Neelakantan S, Siegler M, Crooks PA. (E)-1-[(2-Methoxyphenyl)methyleneamino]-guanidinium chloride Acta Crystallographica Section E: Structure Reports Online. 63: o535-o536. DOI: 10.1107/S1600536806055383  0.306
2006 Chen J, Deaciuc AG, Dwoskin LP, Crooks PA, Bai D. N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors. Journal of Enzyme Inhibition and Medicinal Chemistry. 21: 667-80. PMID 17252939 DOI: 10.1080/14756360600900513  0.331
2006 Sonar VN, Parkin S, Crooks PA. 1-(1H-Indol-3-ylcarbonyl)-N-(4-methoxybenzyl)formamide Acta Crystallographica Section C: Crystal Structure Communications. 62. PMID 16518054 DOI: 10.1107/S0108270106003441  0.328
2006 Chandrasekaran S, Al-Ghananeem AM, Riggs RM, Crooks PA. Synthesis and stability of two indomethacin prodrugs. Bioorganic & Medicinal Chemistry Letters. 16: 1874-9. PMID 16439128 DOI: 10.1016/J.Bmcl.2006.01.003  0.301
2006 Zheng F, Bayram E, Sumithran SP, Ayers JT, Zhan CG, Schmitt JD, Dwoskin LP, Crooks PA. QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release. Bioorganic & Medicinal Chemistry. 14: 3017-37. PMID 16431111 DOI: 10.1016/J.Bmc.2005.12.036  0.327
2006 Guzman ML, Rossi RM, Li X, Corbett C, Hassane DC, Bushnell T, Carroll M, Sullivan E, Neelakantan S, Crooks PA, Jordan CT. A Novel Orally Available Parthenolide Analog Selectively Eradicates AML Stem and Progenitor Cells. Blood. 108: 237-237. DOI: 10.1182/Blood.V108.11.237.237  0.325
2006 Sonar VN, Venkataraj M, Parkin S, Crooks PA. (Z)-2-(Cyclohexylidene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section E Structure Reports Online. 62: o5576-o5577. DOI: 10.1107/S1600536806047453  0.305
2006 Sonar VN, Sean P, Crooks PA. 1-(Azepan-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806029837  0.307
2006 Sonar VN, Parkin S, Crooks PA. 1-(4-tert-Butylbenzyl)-1H-indole-3-carbaldehyde Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806026900  0.305
2006 Sonar VN, Parkin S, Crooks PA. Methyl (E)-2-cyano-3-(1H-indol-3-yl)acrylate Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806004892  0.316
2006 Sonar VN, Parkin S, Crooks PA. (Z)-2-[1-(4-Methylphenylsulfonyl)-1H-indol-3-ylmethylene]-1-azabicyclo[2.2. 2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806001103  0.32
2006 Sonar VN, Parkin S, Crooks PA. (Z)-2-(4-Methoxybenzylidene)-1-azabicyclo[2.2.2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536805042637  0.301
2006 Sonar VN, Parkin S, Crooks PA. N-(2,5-Dichlorophenyl)-N′-[(E)-3-thienyl-methylene]hydrazine Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S160053680501634X  0.324
2005 Wilkins LH, Miller DK, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of antagonists at alpha 4 beta 2* nicotinic acetylcholine receptors: inhibition of S(-)-nicotine-evoked 86Rb+ efflux from rat thalamic synaptosomes. The Aaps Journal. 7: E922-30. PMID 16594645 DOI: 10.1208/Aapsj070490  0.364
2005 Ayers JT, Xu R, Dwoskin LP, Crooks PA. A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine. The Aaps Journal. 7: E752-8. PMID 16353951 DOI: 10.1208/Aapsj070375  0.311
2005 Ayers JT, Clauset A, Schmitt JD, Dwoskin LP, Crooks PA. Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the alpha4beta2 nicotinic acetylcholine receptor subtype using nonlinear techniques. The Aaps Journal. 7: E678-85. PMID 16353944 DOI: 10.1208/Aapsj070368  0.324
2005 Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-Methoxybenzylidene)-1-aza-bicyclo[2.2.2]octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 61. PMID 16272604 DOI: 10.1107/S0108270105030593  0.302
2005 Wei X, Sumithran SP, Deaciuc AG, Burton HR, Bush LP, Dwoskin LP, Crooks PA. Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors. Life Sciences. 78: 495-505. PMID 16197964 DOI: 10.1016/J.Lfs.2005.09.009  0.337
2005 Sumithran SP, Crooks PA, Xu R, Zhu J, Deaciuc AG, Wilkins LH, Dwoskin LP. Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity. The Aaps Journal. 7: E201-17. PMID 16146341 DOI: 10.1208/Aapsj070119  0.355
2005 Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands. Bioorganic & Medicinal Chemistry Letters. 15: 4463-6. PMID 16112864 DOI: 10.1016/J.Bmcl.2005.07.032  0.319
2005 Zheng G, Dwoskin LP, Deaciuc AG, Norrholm SD, Crooks PA. Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter. Journal of Medicinal Chemistry. 48: 5551-60. PMID 16107155 DOI: 10.1021/Jm0501228  0.396
2005 Sonar VN, Parkin S, Crooks PA. (E)-2-Methyl-3-(2-methyl-2-nitrovinyl)-1H-indole and (E)-3-(2-methyl-2- nitrovinyl)-2-phenyl-1H-indole Acta Crystallographica Section C: Crystal Structure Communications. 61. PMID 16082109 DOI: 10.1107/S0108270105022298  0.322
2005 Sonar VN, Parkin S, Crooks PA. (Z)-3-(1H-Indol-3-yl)-2-(3-thienyl)-acrylonitrile and (Z)-3-[1-(4-tert- butylbenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile Acta Crystallographica Section C: Crystal Structure Communications. 61. PMID 15695916 DOI: 10.1107/S0108270104032925  0.331
2005 Sonar VN, Parkin S, Crooks PA. (2E,4E)-8-Methyl-2,4-bis(3-thienylmethylene)-8-azabicyclo[3.2.1]octan-3-one Acta Crystallographica Section E Structure Reports Online. 61: o3445-o3446. DOI: 10.1107/S160053680503028X  0.327
2005 Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-Nitrobenzylidene)-1-azabicyclo[2.2.2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S1600536805028576  0.307
2005 Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-Thienyl)-3-(3,4,5-trimethoxyphenyl)-acrylonitrile Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S160053680500680X  0.3
2004 Sonar VN, Parkin S, Crooks PA. 1-(2,5-Dichlorophenyl)-3-methyl-5-phenyl-1H-pyrazole Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 15295183 DOI: 10.1107/S0108270104013848  0.327
2004 Miller DK, Crooks PA, Zheng G, Grinevich VP, Norrholm SD, Dwoskin LP. Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters. The Journal of Pharmacology and Experimental Therapeutics. 310: 1035-45. PMID 15121762 DOI: 10.1124/Jpet.104.068098  0.329
2004 Crooks PA, Ayers JT, Xu R, Sumithran SP, Grinevich VP, Wilkins LH, Deaciuc AG, Allen DD, Dwoskin LP. Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorganic & Medicinal Chemistry Letters. 14: 1869-74. PMID 15050618 DOI: 10.1016/J.Bmcl.2003.10.074  0.306
2004 Dwoskin LP, Sumithran SP, Zhu J, Deaciuc AG, Ayers JT, Crooks PA. Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents. Bioorganic & Medicinal Chemistry Letters. 14: 1863-7. PMID 15050617 DOI: 10.1016/J.Bmcl.2003.10.073  0.347
2004 Sonar VN, Parkin S, Crooks PA. (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 15004388 DOI: 10.1107/S0108270104002550  0.352
2004 Sonar VN, Parkin S, Crooks PA. (Z)-2-(1H-Indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 14712032 DOI: 10.1107/S0108270103026076  0.34
2004 Sonar VN, Parkin S, Crooks PA. 2-(1-Methyl-1H-indol-3-ylmethylene)-1-aza-bicyclo[2.2.2] octan-3-one: Acid-catalyzed isomerization of the Z isomer to the E isomer Journal of Chemical Crystallography. 34: 239-244. DOI: 10.1023/B:Jocc.0000022421.28337.De  0.301
2003 Bence AK, Crooks PA. The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery. Journal of Enzyme Inhibition and Medicinal Chemistry. 18: 383-94. PMID 14692504 DOI: 10.1080/1475636031000152277  0.734
2003 Sonar VN, Parkin S, Crooks PA. (Z)-2-(3-hydroxy-4-methoxybenzyl-idene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section C: Crystal Structure Communications. 59. PMID 14605418 DOI: 10.1107/S0108270103022339  0.313
2003 Grinevich VP, Crooks PA, Sumithran SP, Haubner AJ, Ayers JT, Dwoskin LP. N-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices. The Journal of Pharmacology and Experimental Therapeutics. 306: 1011-20. PMID 12766255 DOI: 10.1124/jpet.103.051789  0.786
2003 Bence AK, Adams VR, Crooks PA. L-Canavanine as a radiosensitization agent for human pancreatic cancer cells. Molecular and Cellular Biochemistry. 244: 37-43. PMID 12701807 DOI: 10.1023/A:1022435202066  0.739
2003 de Leon J, Diaz FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OA, Dwoskin LP, Crooks PA. Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokers. Journal of Clinical Psychopharmacology. 23: 209-11. PMID 12640226 DOI: 10.1097/00004714-200304000-00018  0.745
2003 Allen DD, Lockman PR, Roder KE, Dwoskin LP, Crooks PA. Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter. The Journal of Pharmacology and Experimental Therapeutics. 304: 1268-74. PMID 12604705 DOI: 10.1124/Jpet.102.045856  0.308
2003 Bence AK, Worthen DR, Stables JP, Crooks PA. An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine. Pharmacology, Biochemistry, and Behavior. 74: 771-5. PMID 12543244 DOI: 10.1016/S0091-3057(02)01079-1  0.737
2003 Wilkins LH, Grinevich VP, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonists: interaction with alpha4beta2* and alpha7* neuronal nicotinic receptors. The Journal of Pharmacology and Experimental Therapeutics. 304: 400-10. PMID 12490617 DOI: 10.1124/Jpet.102.043349  0.346
2003 Chen J, Norrholm S, Dwoskin LP, Crooks PA, Bai D. N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry Letters. 13: 97-100. PMID 12467625 DOI: 10.1016/S0960-894X(02)00849-1  0.347
2003 Sonar VN, Parkin S, Crooks PA. 2-(1-Benzyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section E: Structure Reports Online. 59. DOI: 10.1107/S1600536803019809  0.334
2003 Zhu J, Crooks PA, Ayers JT, Sumithran SP, Dwoskin LP. N-n-Alkylnicotinium and N-n-Alkylpyridinium Analogs Inhibit the Dopamine Transporter: Selectivity as Nicotinic Receptor Antagonists Drug Development Research. 60: 270-284. DOI: 10.1002/Ddr.10328  0.35
2002 Ring JR, Haubner AJ, Crooks PA. Novel antiepileptic and anticonvulsive therapeutic agents. Idrugs : the Investigational Drugs Journal. 5: 990-9. PMID 12800062  0.756
2002 Ayers JT, Dwoskin LP, Deaciuc AG, Grinevich VP, Zhu J, Crooks PA. bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors. Bioorganic & Medicinal Chemistry Letters. 12: 3067-71. PMID 12372503 DOI: 10.1016/S0960-894X(02)00687-X  0.341
2002 Wilkins LH, Haubner A, Ayers JT, Crooks PA, Dwoskin LP. N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonist: inhibition of S(-)-nicotine-evoked [(3)H]dopamine overflow from superfused rat striatal slices. The Journal of Pharmacology and Experimental Therapeutics. 301: 1088-96. PMID 12023541 DOI: 10.1124/Jpet.301.3.1088  0.786
2002 Bence AK, Worthen DR, Adams VR, Crooks PA. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anti-Cancer Drugs. 13: 313-20. PMID 11984075 DOI: 10.1097/00001813-200203000-00013  0.731
2002 Bence AK, Crooks PA. Synthesis of L-indospicine Synthetic Communications. 32: 2075-2082. DOI: 10.1081/Scc-120004860  0.727
2002 Xu R, Dwoskin LP, Grinevich V, Sumithran SP, Crooks PA. Synthesis and evaluation of conformationally restricted pyridino N-alkylated nicotine analogs as nicotinic acetylcholine receptor antagonists Drug Development Research. 55: 173-186. DOI: 10.1002/Ddr.10049  0.382
2001 Green TA, Crooks PA, Bardo MT, Dwoskin LP. Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices. Biochemical Pharmacology. 62: 1597-603. PMID 11755112 DOI: 10.1016/S0006-2952(01)00838-3  0.318
2001 Truong A, Xing X, Forsayeth JR, Dwoskin LP, Crooks PA, Cohen BN. Pharmacological differences between immunoisolated native brain and heterologously expressed rat alpha4beta2 nicotinic receptors. Brain Research. Molecular Brain Research. 96: 68-76. PMID 11731010 DOI: 10.1016/S0169-328X(01)00268-6  0.311
2001 Xu R, Dwoskin LP, Grinevich VP, Deaciuc G, Crooks PA. Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues. Bioorganic & Medicinal Chemistry Letters. 11: 1245-8. PMID 11354387 DOI: 10.1016/S0960-894X(01)00193-7  0.325
2001 Ghosheh OA, Dwoskin LP, Miller DK, Crooks PA. Accumulation of nicotine and its metabolites in rat brain after intermittent or continuous peripheral administration of [2'-(14)C]nicotine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 645-51. PMID 11302929  0.764
2001 Worthen DR, Gibson DA, Rogers DT, Bence AK, Fu M, Littleton JM, Crooks PA. Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex. Brain Research. 890: 343-6. PMID 11164802 DOI: 10.1016/S0006-8993(00)03201-7  0.751
2000 Byrd GD, Caldwell WS, Bhatti BS, Ravard A, Crooks PA. Determination of nicotine N-1-glucuronide, a quaternary N-glucuronide conjugate, in human biological samples. Drug Metabolism and Drug Interactions. 16: 281-97. PMID 11201307 DOI: 10.1515/Dmdi.2000.16.4.281  0.313
2000 Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex. Bioorganic & Medicinal Chemistry Letters. 10: 2621-3. PMID 11128637 DOI: 10.1016/S0960-894X(00)00530-8  0.74
2000 Miller DK, Crooks PA, Dwoskin LP. Lobeline inhibits nicotine-evoked [(3)H]dopamine overflow from rat striatal slices and nicotine-evoked (86)Rb(+) efflux from thalamic synaptosomes. Neuropharmacology. 39: 2654-62. PMID 11044735 DOI: 10.1016/S0028-3908(00)00140-4  0.315
2000 Ghosheh OA, Browne D, Rogers T, de Leon J, Dwoskin LP, Crooks PA. A simple high performance liquid chromatographic method for the quantification of total cotinine, total 3'-hydroxycotinine and caffeine in the plasma of smokers. Journal of Pharmaceutical and Biomedical Analysis. 23: 543-9. PMID 10933548 DOI: 10.1016/S0731-7085(00)00339-3  0.767
2000 Bence AK, Rogers DT, Worthen DR, Fu M, Littleton JM, Crooks PA. Dapsone analogs as potential polyamine binding site modulators of the N-methyl-D-aspartate receptor complex Drug Development Research. 51: 268-272. DOI: 10.1002/Ddr.8  0.754
1999 Ghosheh OA, Houdi AA, Crooks PA. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). Journal of Pharmaceutical and Biomedical Analysis. 19: 757-62. PMID 10698539 DOI: 10.1016/S0731-7085(98)00300-8  0.766
1999 Dwoskin LP, Wilkins LH, Pauly JR, Crooks PA. Development of a novel class of subtype-selective nicotinic receptor antagonist: pyridine-N-substituted nicotine analogs. Annals of the New York Academy of Sciences. 868: 617-9. PMID 10414342 DOI: 10.1111/J.1749-6632.1999.Tb11334.X  0.312
1998 Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Research. 18: 1527-32. PMID 9673365  0.774
1998 Crooks PA, Ravard A, Byrd GD. Synthesis of (E)-N-[methyl-d3]- 4-(3-pyridinyl)-3-buten-1-amine, a deuterated analogue of the nicotinic agonist RJR-2403 Journal of Labelled Compounds and Radiopharmaceuticals. 41: 1165-1171. DOI: 10.1002/(Sici)1099-1344(199812)41:12<1165::Aid-Jlcr162>3.0.Co;2-G  0.303
1997 Phuket SRN, Trifonov LS, Crooks PA, Rosenthal GA, Freeman JW, Strodel WE. Synthesis and structure-activity studies of some antitumor congeners of L-canavanine Drug Development Research. 40: 325-332. DOI: 10.1002/(Sici)1098-2299(199704)40:4<325::Aid-Ddr6>3.0.Co;2-L  0.319
1996 Deo NM, Crooks PA. Regioselective alkylation of N-(diphenylmethylidine)-3-(aminomethyl)pyridine: A simple route to minor tobacco alkaloids and related compounds Tetrahedron Letters. 37: 1137-1140. DOI: 10.1016/0040-4039(96)00002-0  0.339
1996 Ravard A, Crooks PA. Chiral purity determination of tobacco alkaloids and nicotine‐like compounds by 1H NMR spectroscopy in the presence of 1,1′‐binaphthyl‐2,2′‐diylphosphoric acid Chirality. 8: 295-299. DOI: 10.1002/(Sici)1520-636X(1996)8:4<295::Aid-Chir1>3.0.Co;2-F  0.348
1995 Dwoskin LP, Teng L, Buxton ST, Ravard A, Deo N, Crooks PA. Minor alkaloids of tobacco release [3H]dopamine from superfused rat striatal slices. European Journal of Pharmacology. 276: 195-9. PMID 7781690 DOI: 10.1016/0014-2999(95)00077-X  0.301
1995 Jona JA, Dittert LW, Crooks PA, Milosovich SM, Hussain AA. Design of novel prodrugs for the enhancement of the transdermal penetration of indomethacin International Journal of Pharmaceutics. 123: 127-136. DOI: 10.1016/0378-5173(95)00061-M  0.305
1995 Chen J, Crooks PA, Hussain A. Kinetics and mechanism of hydrolysis of amidals: Their relative stability compared to structurally related acetals and acylals International Journal of Pharmaceutics. 123: 95-101. DOI: 10.1016/0378-5173(95)00044-J  0.336
1995 Crooks PA, Ravard A, Wilkins LH, Teng LH, Buxton ST, Dwoskin LP. Inhibition of nicotine-evoked [3H]dopamine release by pyridino N-substituted nicotine analogues: A new class of nicotinic antagonist Drug Development Research. 36: 91-102. DOI: 10.1002/Ddr.430360204  0.354
1994 Byrd GD, Uhrig MS, deBethizy JD, Caldwell WS, Crooks PA, Ravard A, Riggs Rm. Direct determination of cotinine-N-glucuronide in urine using thermospray liquid chromatography/mass spectrometry. Biological Mass Spectrometry. 23: 103-7. PMID 8123688 DOI: 10.1002/Bms.1200230210  0.31
1994 Ravard A, Crooks PA. Synthesis of racemic [methyl‐d3]‐iabeled cis‐ and trans‐3′‐hydroxycotinine Journal of Labelled Compounds and Radiopharmaceuticals. 34: 1001-1009. DOI: 10.1002/Jlcr.2580341102  0.303
1992 Caldwell WS, Greene JM, Byrd GD, Chang KM, Uhrig MS, deBethizy JD, Crooks PA, Bhatti BS, Riggs RM. Characterization of the glucuronide conjugate of cotinine: a previously unidentified major metabolite of nicotine in smokers' urine. Chemical Research in Toxicology. 5: 280-5. PMID 1643259 DOI: 10.1021/Tx00026A021  0.308
1992 Dwoskin LP, Leibee LL, Jewell AL, Fang ZX, Crooks PA. Inhibition of [3H]dopamine uptake into rat striatal slices by quaternary N-methylated nicotine metabolites. Life Sciences. 50: PL233-7. PMID 1593921 DOI: 10.1016/0024-3205(92)90533-U  0.359
1990 Crooks PA, Hassan SF, Benghiat E, Hemrick-Luecke SK, Fuller RW. 5'-thioadenosine derivatives as potent and selective inhibitors of histamine N-methyltransferase. Drug Metabolism and Drug Interactions. 7: 111-41. PMID 2630176 DOI: 10.1515/Dmdi.1989.7.2-3.111  0.357
1989 Nwosu CG, Godin CS, Houdi AA, Damani LA, Crooks PA. Enantioselective metabolism during continuous administration of S-(-)- and R-(+)-nicotine isomers to guinea-pigs. The Journal of Pharmacy and Pharmacology. 40: 862-9. PMID 2907579 DOI: 10.1111/J.2042-7158.1988.Tb06289.X  0.301
1989 Crooks PA, Deeks T, Desimone F. Synthesis of 5‐benzoyl‐5‐phenyl‐ and 5‐phenylhydroxymethyl‐5‐phenylhydantoins as potential anticonvulsants Journal of Heterocyclic Chemistry. 26: 1113-1117. DOI: 10.1002/Jhet.5570260439  0.309
1988 Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB. Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases. Biochemical Pharmacology. 37: 1673-7. PMID 3377829 DOI: 10.1016/0006-2952(88)90426-1  0.312
1987 Cundy KC, Crooks PA. Biotransformation of primary nicotine metabolites II. Metabolism of [3h]-s-(-)-cotinine in the Guinea pig: Determination of in vivo urinary metabolites by high-performance liquid-radiochromatography Xenobiotica. 17: 785-792. PMID 3660848 DOI: 10.3109/00498258709043987  0.301
1986 Godin CS, Crooks PA, Damani LA. N-methylation of phenylpyridines and bispyridyls as a potential toxication route: Tissue distribution of azaheterocycle n-methyltransferase activity in the rabbit Toxicology Letters. 34: 217-222. PMID 3798480 DOI: 10.1016/0378-4274(86)90213-4  0.307
1986 Crooks PA, Burn P, Sewell RD, Upton N. Synthesis and antinociceptive properties of a series of exo- and endo-6-hydroxy-2-aminobenzonorbornenes. Journal of Pharmaceutical Sciences. 75: 1010-3. PMID 3795019 DOI: 10.1002/Jps.2600751022  0.329
1986 Damani LA, Shaker MS, Crooks PA, Godin CS, Nwosu C. N-methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosyl-L-methionine-dependent reaction. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 16: 645-50. PMID 3751119 DOI: 10.3109/00498258609043554  0.324
1986 Damani LA, Shaker MS, Godin CS, Crooks PA, Ansher SS, Jakoby WB. The ability of amine N-methyltransferases from rabbit liver to N-methylate azaheterocycles. The Journal of Pharmacy and Pharmacology. 38: 547-50. PMID 2875161 DOI: 10.1111/J.2042-7158.1986.Tb04636.X  0.33
1985 Sommerville R, Rosenberg HE, Crooks PA. Synthesis and pharmacological evaluation of aromatic dihydroxylated spiro[indan‐1,3′‐pyrrolidine] and spiro[indan‐2,2′‐pyrrolidine] derivatives Journal of Pharmaceutical Sciences. 74: 553-555. PMID 4020632 DOI: 10.1002/Jps.2600740512  0.314
1984 Cundy KC, Crooks PA. High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine Journal of Chromatography B: Biomedical Sciences and Applications. 306: 291-301. PMID 6715467 DOI: 10.1016/S0378-4347(00)80891-9  0.304
1983 Damani LA, Crooks PA, Shaker MS, Caldwell J, D'Souza J, Smith RL. Species differences in the metabolic C- and N-oxidation , and N-methylation of [14C]pyridine in vivo. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 12: 527-34. PMID 7147998 DOI: 10.3109/00498258209038931  0.302
1983 Deeks T, Crooks PA, Waigh RD. Synthesis and analgesic properties of two leucine-enkephalin analogues containing a conformationally restrained N-terminal tyrosine residue Journal of Medicinal Chemistry. 26: 762-765. PMID 6842517 DOI: 10.1002/Chin.198338346  0.314
1983 Benghiat E, Crooks PA. Multisubstrate adducts as potential inhibitors of S-adenosylmethionine dependent methylases: Inhibition of indole N-methyltransferase by (5′-deoxyadenosyl)[3-(3-indolyl)prop-1-yl]methylsulfonium and (5′-deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium salts Journal of Medicinal Chemistry. 26: 1470-1477. PMID 6620306 DOI: 10.1021/Jm00364A021  0.361
1982 Burn P, Crooks PA, Heatley F, Costall B, Naylor RJ, Nohria V. Synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine. Journal of Medicinal Chemistry. 25: 363-8. PMID 7200145 DOI: 10.1002/Chin.198240136  0.345
1982 Crooks PA, Sommerville R. The synthesis and analgesic activities of some spiro[indan‐1,3′‐pyrrolidine] derivatives designed as rigid analogs of profadol Journal of Pharmaceutical Sciences. 71: 291-294. PMID 6461753 DOI: 10.1002/Jps.2600710306  0.3
1980 Crooks PA, Szyndler R. Synthesis and analgesic properties of some conformationally restricted analogues of profadol Journal of Medicinal Chemistry. 23: 679-682. PMID 6446605 DOI: 10.1021/Jm00180A021  0.342
1979 Crooks PA, Rosenberg HE. Synthesis of 5-hydroxy- and 5,6-dihydroxy-derivatives of spiro[indane-2,2′-pyrrolidine], rigid analogues of tyramine and dopamine respectively Journal of the Chemical Society, Perkin Transactions 1. 2719-2726. DOI: 10.1039/P19790002719  0.364
1978 Crooks PA, Rosenberg HE. Synthesis of spiro[tetralin-2,2′-pyrrolidine] and spiro[indan-2,2′-pyrrolidine] derivatives as potential analgesics Journal of Medicinal Chemistry. 21: 585-587. PMID 671457 DOI: 10.1021/Jm00204A016  0.343
Low-probability matches (unlikely to be authored by this person)
2008 Rahman S, Neugebauer NM, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. The novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide decreases nicotine-induced dopamine metabolism in rat nucleus accumbens. European Journal of Pharmacology. 601: 103-5. PMID 19000671 DOI: 10.1016/J.Ejphar.2008.10.037  0.3
2004 Sonar VN, Parkin S, Crooks PA. (E)-N-[(Benzo[b]thiophen-3-yl)methylene]-N′-(2,5-dichlorophenyl) -hydrazine Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 15295184 DOI: 10.1107/S0108270104013873  0.3
2007 Sonar VN, Parkin S, Crooks PA. (E)-3-(Benzo[b]thiophen-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile and (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile Acta Crystallographica Section C: Crystal Structure Communications. 63. PMID 18057629 DOI: 10.1107/S0108270107054959  0.299
2006 Sonar VN, Venkataraj M, Parkin S, Crooks PA. (Z)-2-(1,3-Benzodioxol-5-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section E Structure Reports Online. 62: o5742-o5744. DOI: 10.1107/S160053680604894X  0.298
2006 Sonar VN, Parkin S, Crooks PA. (Z)-2-(2-Methoxybenzylidene)-1-azabicyclo[2.2.2]-octan-3-one Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536805042625  0.298
2013 Banothu J, Velpula R, Gali R, Bavantula R, Crooks PA. Highly efficient conversion of fused 2-amino-4-aryl-4H-chromene-3-carbonitriles into fused 2-oxo-4-aryl-2H-chromene-3-carbonitriles using Vilsmeier conditions Tetrahedron Letters. 54: 3862-3864. DOI: 10.1016/J.Tetlet.2013.05.030  0.298
2007 Al-Ghananeem AM, Albayati ZF, Malkawi A, Sonar VN, Freeman ML, Crooks PA. A pharmacokinetic study on Z-(+/-)-2-(1-benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a novel radio-sensitization agent. Cancer Chemotherapy and Pharmacology. 60: 915-9. PMID 17294191 DOI: 10.1007/S00280-007-0425-8  0.298
2006 Neugebauer NM, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats. Psychopharmacology. 184: 426-34. PMID 16220336 DOI: 10.1007/S00213-005-0163-8  0.297
2005 Geldenhuys WJ, Lockman PR, Nguyen TH, Van der Schyf CJ, Crooks PA, Dwoskin LP, Allen DD. 3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry. 13: 4253-61. PMID 15878282 DOI: 10.1016/J.Bmc.2005.04.020  0.297
1993 Glemarec C, Reynolds RC, Crooks PA, Maddry JA, Akhtar MS, Montgomery JA, Secrist JA, Chattopadhyaya J. Conformational studies of thymidine dimers containing sulfonate and sulfonamide linkages by NMR spectroscopy Tetrahedron. 49: 2287-2298. DOI: 10.1016/S0040-4020(01)80372-0  0.297
1988 Nwosu CG, Crooks PA. Species variation and stereoselectivity in the metabolism of nicotine enantiomers. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 18: 1361-72. PMID 3245230 DOI: 10.3109/00498258809042260  0.297
2005 Sonar VN, Parkin S, Crooks PA. 6α-Acetoxy-4,5α-epoxy-3-methoxy-17-methyl-morphin-7-ene Acta Crystallographica Section E: Structure Reports Online. 61. DOI: 10.1107/S1600536805022130  0.297
1985 Cundy KC, Crooks PA, Steven Godin C. Remarkable substrate-inhibitor properties of nicotine enantiomers towards a guinea pig lung aromatic azaheterocycle N-methyltransferase Biochemical and Biophysical Research Communications. 128: 312-316. PMID 3985972 DOI: 10.1016/0006-291X(85)91680-8  0.296
2016 Liu X, Gujarathi S, Zhang X, Shao L, Boerma M, Compadre CM, Crooks PA, Hauer-Jensen M, Zhou D, Zheng G. Synthesis of (2R,8' S,3' E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol. Tetrahedron. 72: 4001-4006. PMID 27773949 DOI: 10.1016/J.Tet.2016.05.028  0.296
1985 Cundy KC, Godin CS, Crooks PA. Stereospecific in vitro N-methylation of nicotine in guinea pig tissues by an S-adenosylmethionine-dependent N-methyltransferase Biochemical Pharmacology. 34: 281-284. PMID 3966930 DOI: 10.1016/0006-2952(85)90137-6  0.296
1979 Deeks T, Crooks PA, Waigh RD. The synthesis and in vitro pharmacological evaluation of some novel enkephalin analogues Journal of Pharmacy and Pharmacology. 31. PMID 42739 DOI: 10.1111/J.2042-7158.1979.Tb11610.X  0.295
2018 Lamture G, Crooks PA, Borrelli MJ. Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells. Drug Development Research. 79: 287-294. PMID 30295945 DOI: 10.1002/Ddr.21441  0.295
1995 Swaffar DS, Ang CY, Desai PB, Rosenthal GA, Thomas DA, Crooks PA, John WJ. Combination therapy with 5-fluorouracil and L-canavanine: in vitro and in vivo studies. Anti-Cancer Drugs. 6: 586-93. PMID 7579563 DOI: 10.1097/00001813-199508000-00012  0.295
2003 Sonar VN, Parkin S, Crooks PA. (Z)-2-Thio­phen-3-yl­methyl­ene-1-aza-bi­cyclo­[2.2.2]­octan-3-one Acta Crystallographica Section E: Crystallographic Communications. 59. DOI: 10.1107/S1600536803019007  0.294
2012 Wala EP, Crooks PA, McIntosh JM, Holtman JR. Novel small molecule α9α10 nicotinic receptor antagonist prevents and reverses chemotherapy-evoked neuropathic pain in rats. Anesthesia and Analgesia. 115: 713-20. PMID 22610850 DOI: 10.1213/Ane.0B013E31825A3C72  0.294
2011 Zheng G, Zhang Z, Dowell C, Wala E, Dwoskin LP, Holtman JR, McIntosh JM, Crooks PA. Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain. Bioorganic & Medicinal Chemistry Letters. 21: 2476-9. PMID 21397497 DOI: 10.1016/J.Bmcl.2011.02.043  0.294
1983 Cundy KC, Crooks PA. Unexpected pehnomenon in the high-performance liquid chromatographic anlaysis of racemic 14C-labelled nicotine: Separation of enantiomers in a totally achiral system Journal of Chromatography A. 281: 17-33. DOI: 10.1016/S0021-9673(01)87863-8  0.294
2009 Zheng F, Dwoskin LP, Crooks PA, Zhan CG. First-Principles Determination of Molecular Conformations of Indolizidine (-)-235B' in Solution. Theoretical Chemistry Accounts. 124: 269-278. PMID 20161506 DOI: 10.1007/S00214-009-0607-Z  0.293
1996 Worthen DR, Ratliff DK, Rosenthal GA, Trifonov L, Crooks PA. Structure-activity studies of L-canaline-mediated inhibition of porcine alanine aminotransferase Chemical Research in Toxicology. 9: 1293-1297. PMID 8951231 DOI: 10.1021/Tx9600199  0.293
1990 Tawfiq FA, Hussain A, Dittert L, Crooks PA. Kinetics of decomposition of O-acyl derivatives of salicylamide and related compounds International Journal of Pharmaceutics. 64: 45-53. DOI: 10.1016/0378-5173(90)90177-6  0.293
2008 Rahman S, Zhang Z, Papke RL, Crooks PA, Dwoskin LP, Bardo MT. Region-specific effects of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular dopamine in vivo. British Journal of Pharmacology. 153: 792-804. PMID 18059317 DOI: 10.1038/Sj.Bjp.0707612  0.293
2002 Dwoskin LP, Crooks PA. A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse. Biochemical Pharmacology. 63: 89-98. PMID 11841781 DOI: 10.1016/S0006-2952(01)00899-1  0.293
2010 Nickell JR, Krishnamurthy S, Norrholm S, Deaciuc G, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2. The Journal of Pharmacology and Experimental Therapeutics. 332: 612-21. PMID 19855096 DOI: 10.1124/Jpet.109.160275  0.293
2007 Rahman S, Neugebauer NM, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. The effects of a novel nicotinic receptor antagonist N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on acute and repeated nicotine-induced increases in extracellular dopamine in rat nucleus accumbens. Neuropharmacology. 52: 755-63. PMID 17097117 DOI: 10.1016/J.Neuropharm.2006.09.012  0.292
2010 Hassane DC, Sen S, Minhajuddin M, Rossi RM, Corbett CA, Balys M, Wei L, Crooks PA, Guzman ML, Jordan CT. Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways. Blood. 116: 5983-90. PMID 20889920 DOI: 10.1182/Blood-2010-04-278044  0.292
1985 SOMMERVILLE R, ROSENBERG HE, CROOKS PA. ChemInform Abstract: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF AROMATIC DIHYDROXYLATED SPIRO(INDAN-1,3′-PYRROLIDINE) AND SPIRO(INDAN-2,2′-PYRROLIDINE) DERIVATIVES Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198545162  0.292
1995 Rosenthal GA, Dahlman DL, Crooks PA, Phuket SN, Trifonov LS. Insecticidal properties of some derivatives of L-canavanine Journal of Agricultural and Food Chemistry. 43: 2728-2734. DOI: 10.1021/Jf00058A034  0.292
2009 Madhav JV, Reddy YT, Reddy PN, Crooks PA, Kumar VN, Rajitha B. Sulfamic acid catalyzed one-pot synthesis of 2,5-diaryl-1,3,4-oxadiazoles under microwave irradiation and conventional heating Journal of Heterocyclic Chemistry. 46: 289-293. DOI: 10.1002/Jhet.4  0.292
1999 Shafaee N, Houng M, Truong A, Viseshakul N, Figl A, Sandhu S, Forsayeth JR, Dwoskin LP, Crooks PA, Cohen BN. Pharmacological similarities between native brain and heterologously expressed alpha4beta2 nicotinic receptors. British Journal of Pharmacology. 128: 1291-9. PMID 10578144 DOI: 10.1038/Sj.Bjp.0702900  0.291
2009 Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA. Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues. The Journal of Organic Chemistry. 74: 6072-6. PMID 20560567 DOI: 10.1021/Jo901082R  0.291
2014 Nickell JR, Siripurapu KB, Vartak A, Crooks PA, Dwoskin LP. The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse. Advances in Pharmacology (San Diego, Calif.). 69: 71-106. PMID 24484975 DOI: 10.1016/B978-0-12-420118-7.00002-0  0.291
2005 Papke RL, Zheng G, Horenstein NA, Dwoskin LP, Crooks PA. The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion. Bioorganic & Medicinal Chemistry Letters. 15: 3874-80. PMID 16005216 DOI: 10.1016/J.Bmcl.2005.05.118  0.29
2003 Sonar VN, Parkin S, Crooks PA. (Z)-2-(Benzo[b]thiophen-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section E Structure Reports Online. 59: o1726-o1728. DOI: 10.1107/S1600536803022797  0.29
2000 Hussain AA, Jona J, Crooks PA. Competitive inhibitory effect of external nucleophile concentration on intramolecular O- to N-acylation in O-acetylsalicylamide Aaps Pharmscitech [Electronic Resource]. 1. PMID 14727901 DOI: 10.1208/Pt0103_Tn1  0.29
2001 Dwoskin LP, Teng LH, Crooks PA. Nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum. European Journal of Pharmacology. 428: 69-79. PMID 11779039 DOI: 10.1016/S0014-2999(01)01283-3  0.29
2013 Ding D, Dwoskin LP, Crooks PA. Efficient synthesis of cis-2,6-di-(2- quinolylpiperidine). Tetrahedron Letters. 54: 5211-5213. PMID 24511163 DOI: 10.1016/J.Tetlet.2013.07.067  0.289
1984 Layton WJ, Smith SL, Crooks PA, Deeks T, Waigh RD. Synthesis and stereochemical analysis of 2-amino-1,2,3,4-tetrahydro-1,4-methanonaphthalene-2-carboxylic acid, a conformationally rigid phenylalanine derivative Journal of the Chemical Society-Perkin Transactions 1. 15: 1283-1287. DOI: 10.1039/P19840001283  0.289
2009 Geng L, Rachakonda G, Morré DJ, Morré DM, Crooks PA, Sonar VN, Roti JL, Rogers BE, Greco S, Ye F, Salleng KJ, Sasi S, Freeman ML, Sekhar KR. Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2986-95. PMID 19395476 DOI: 10.1096/Fj.09-130005  0.289
2004 Li S, Crooks PA, Wei X, de Leon J. Toxicity of dipyridyl compounds and related compounds. Critical Reviews in Toxicology. 34: 447-60. PMID 15560568 DOI: 10.1080/10408440490503143  0.289
2015 Bommagani S, Penthala NR, Parkin S, Crooks PA. Crystal structure of (E)-13-(pyrimidin-5-yl)parthenolide. Acta Crystallographica. Section E, Crystallographic Communications. 71: 1536-8. PMID 26870423 DOI: 10.1107/S2056989015021507  0.289
1998 Teng L, Crooks PA, Dwoskin LP. Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine. Journal of Neurochemistry. 71: 258-65. PMID 9648873 DOI: 10.1046/J.1471-4159.1998.71010258.X  0.288
2006 Sonar VN, Parkin S, Crooks PA. (E)-1-benzyl-3-(2-nitrovinyl)-1H-indole Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806026523  0.288
2014 Sekhar KR, Benamar M, Venkateswaran A, Penthala NR, Crooks PA, Hann SR, Geng L, Balusu R, Abbas T, Freeman ML. Abstract 4905: Targeting NPM1 for the radiosensitization of NSCLC Cancer Research. 74: 4905-4905. DOI: 10.1158/1538-7445.Am2014-4905  0.288
2013 Peng C, Kimbrell MR, Tian C, Pack TF, Crooks PA, Fifer EK, Papke RL. Multiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents. Molecular Pharmacology. 84: 459-75. PMID 23839567 DOI: 10.1124/Mol.113.086462  0.288
2008 Vartak AP, Dwoskin LP, Crooks PA. Synthesis of symmetrical 1,5-disubstituted granatanines. Tetrahedron Letters. 49: 6330-6333. PMID 23678188 DOI: 10.1016/J.Tetlet.2008.08.066  0.288
2003 Sonar VN, Parkin S, Crooks PA. (Z)-2-Thiophen-3-ylmethylene-1-azabicyclo[2.2.2]octan-3-one Acta Crystallographica Section E: Structure Reports Online. 59. DOI: 10.1107/S1600536806049403  0.288
1983 Benghiat E, Crooks PA. Synthesis of s‐3‐indolemethyl derivatives of 5′‐deoxy‐5′‐thioadenosine Journal of Heterocyclic Chemistry. 20: 423-425. DOI: 10.1002/Jhet.5570200229  0.287
2011 Holtman JR, Dwoskin LP, Dowell C, Wala EP, Zhang Z, Crooks PA, McIntosh JM. The novel small molecule α9α10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic. European Journal of Pharmacology. 670: 500-8. PMID 21944926 DOI: 10.1016/J.Ejphar.2011.08.053  0.287
2011 Burnett R, Appaiah H, Bhat-Nakshatri P, Wikel J, Crooks P, Mathews W, Nakshatri H. Abstract 1344: HMGA2-targeted drug discovery for breast cancer brain metastasis Cancer Research. 71: 1344-1344. DOI: 10.1158/1538-7445.Am2011-1344  0.287
1992 Crooks PA, Reynolds RC, Maddry JA, Rathore A, Akhtar MS, Montgomery JA, Secrist JA. Nucleoside sultones: synthons for the preparation of novel nucleotide analogs. 1. Synthesis and ring-opening reactions Journal of Organic Chemistry. 57: 2830-2835. DOI: 10.1021/Jo00036A014  0.286
2020 Karmakar A, Xu Y, Mustafa T, Kannarpady G, Bratton SM, Radominska-Pandya A, Crooks PA, Biris AS. Nanodelivery of Parthenolide Using Functionalized Nanographene Enhances its Anticancer Activity. Rsc Advances. 5: 2411-2420. PMID 25574376 DOI: 10.1039/C4Ra10871J  0.286
2018 Bommagani S, Penthala NR, Parkin S, Crooks PA. Crystal structure of 13-()-(2-amino-benzyl-idene)parthenolide. Acta Crystallographica. Section E, Crystallographic Communications. 74: 1543-1546. PMID 30443377 DOI: 10.1107/S2056989018013622  0.286
1980 BURN P, CROOKS PA, RATCLIFFE BL, REES JMH. Sympathomimetic effects of exo‐ and endo‐ isomers of 2‐aminobenzonorbornene in vitro and in vivo Journal of Pharmacy and Pharmacology. 32: 87-91. PMID 6103048 DOI: 10.1111/J.2042-7158.1980.Tb12858.X  0.286
2007 Nasim S, Parkin S, Crooks PA. (11R)-13-(Benzyl-amino)-4,5-ep-oxy-11,13-dihydro-costunolide Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807041712  0.286
2006 Sonar VN, Parkin S, Crooks PA. 1-(4-Methoxybenzyl)-1H-indole-3-carbaldehyde Acta Crystallographica Section E: Structure Reports Online. 62. DOI: 10.1107/S1600536806025268  0.286
1986 Benghiat E, Crooks PA, Goodwin R, Rottman F. Inhibition of vaccinia RNA guanine 7-methyltransferase by compounds designed as multisubstrate adducts Journal of Pharmaceutical Sciences. 75: 142-145. PMID 3958922 DOI: 10.1002/Jps.2600750207  0.285
2007 Papke RL, Dwoskin LP, Crooks PA. The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery. Journal of Neurochemistry. 101: 160-7. PMID 17241116 DOI: 10.1111/J.1471-4159.2006.04355.X  0.285
2010 Walsby EJ, Pratt G, Hewamana S, Crooks PA, Burnett AK, Fegan C, Pepper C. The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib. Molecular Cancer Therapeutics. 9: 1574-82. PMID 20515939 DOI: 10.1158/1535-7163.Mct-10-0104  0.285
1996 Gosland MP, Gillespie MN, Tsuboi CP, Tofiq S, Olson JW, Crooks PA, Aziz SM. Reversal of doxorubicin, etoposide, vinblastine, and taxol resistance in multidrug resistant human sarcoma cells by a polymer of spermine Cancer Chemotherapy and Pharmacology. 37: 593-600. PMID 8612315 DOI: 10.1007/S002800050434  0.285
2003 Sonar VN, Parkin S, Crooks PA. (Z)-2-(2,4-dimethoxybenzylidene)-1-aza-bicyclo[2.2.2]octan-3-ol Acta Crystallographica Section E: Structure Reports Online. 59. DOI: 10.1107/S1600536803026825  0.285
2004 Zheng G, Parkin S, Dwoskin LP, Crooks PA. Two isomers of 2,4-dibenzyl-8-azabicyclo[3.2.1]octan-3-ol. Acta Crystallographica. Section C, Crystal Structure Communications. 60: o9-11. PMID 14712033 DOI: 10.1107/S0108270103026520  0.284
2010 Shanmugam R, Kusumanchi P, Cheng L, Crooks P, Neelakantan S, Matthews W, Nakshatri H, Sweeney CJ. A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species. The Prostate. 70: 1074-86. PMID 20209491 DOI: 10.1002/Pros.21141  0.283
2009 Dwoskin LP, Smith AM, Wooters TE, Zhang Z, Crooks PA, Bardo MT. Nicotinic receptor-based therapeutics and candidates for smoking cessation. Biochemical Pharmacology. 78: 732-43. PMID 19523455 DOI: 10.1016/J.Bcp.2009.06.002  0.283
2005 Howard-Sparks M, Al-Ghananeem AM, Pearson AP, Crooks PA. Evaluation of O3α-,O21-Di- (N1-methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl) 17α-hydroxy-5β-pregnan-20-one as a novel potential antiangiogenic codrug Journal of Enzyme Inhibition and Medicinal Chemistry. 20: 417-428. PMID 16335049 DOI: 10.1080/14756360500220319  0.283
2015 Zong H, Penthala NR, Sonar VN, Giannakakou P, Roboz GJ, Crooks PA, Guzman ML. Abstract 1667: Targeting acute myelogenous leukemia with novel combrestatin analogs and development of predictors of response Cancer Research. 75: 1667-1667. DOI: 10.1158/1538-7445.Am2015-1667  0.283
2015 Song Jang D, Fahmi T, Penthala NR, Apostolov EO, Crooks PA, Basnakian AG. 584. Improvement of Gene Delivery By Inhibition of Endonucleases Molecular Therapy. 23: S232-S233. DOI: 10.1016/S1525-0016(16)34193-4  0.282
1985 Olson JW, Crooks PA. Effect of nicotine and n'-nitrosonornicotine on rat lung and trachea ornithine decarboxylase activity Carcinogenesis. 6: 1517-1519. PMID 4042278 DOI: 10.1093/Carcin/6.10.1517  0.281
2004 Sonar VN, Parkin S, Crooks PA. (Z)-2-(1-Phenylsulfonyl-1H-indol3-ylmethylene)-1-azabicyclo[2.2.2] -octan-3-one and (Z)-(S)-2-(1-phenylsulfonyl-1H-indol-3-ylmethylene)-1-azabicyclo[2.2.2] octan-3-ol Acta Crystallographica Section C: Crystal Structure Communications. 60. PMID 15345848 DOI: 10.1107/S0108270104015847  0.281
2006 Zheng G, Horton DB, Deaciuc AG, Dwoskin LP, Crooks PA. Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorganic & Medicinal Chemistry Letters. 16: 5018-21. PMID 16905316 DOI: 10.1016/J.Bmcl.2006.07.070  0.281
2009 Vartak AP, Sonar V, Crooks PA. Rac- and R-(+)-[4,4′,5,5′-2H4]-2- (1′-[2″,6″-dichlorophenoxy]-ethyl)-Δ2- imidazoline (lofexidine) Journal of Labelled Compounds and Radiopharmaceuticals. 52: 431-434. DOI: 10.1002/Jlcr.1655  0.281
2013 Horton DB, Nickell JR, Zheng G, Crooks PA, Dwoskin LP. GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine. Journal of Neurochemistry. 127: 177-86. PMID 23875622 DOI: 10.1111/Jnc.12371  0.281
2018 Marecki JC, Aarattuthodiyil S, Byrd AK, Penthala NR, Crooks PA, Raney KD. N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3. Bioorganic & Medicinal Chemistry Letters. PMID 30578035 DOI: 10.1016/J.Bmcl.2018.12.026  0.28
2009 Struthers AM, Wilkinson JL, Dwoskin LP, Crooks PA, Bevins RA. Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacology, Biochemistry, and Behavior. 94: 319-28. PMID 19778551 DOI: 10.1016/J.Pbb.2009.09.012  0.28
2014 Eldridge JA, Milewski M, Stinchcomb AL, Crooks PA. Synthesis and in vitro stability of amino acid prodrugs of 6-β-naltrexol for microneedle-enhanced transdermal delivery. Bioorganic & Medicinal Chemistry Letters. 24: 5212-5. PMID 25442314 DOI: 10.1016/J.Bmcl.2014.09.072  0.28
2004 Sonar VN, Parkin S, Crooks PA. 4-(Benzo[b]thiophen-3-yl)-1-methylpiperidine-4-carbonitrile Acta Crystallographica Section E: Structure Reports Online. 60. DOI: 10.1107/S1600536804019543  0.28
2016 Han YS, Penthala NR, Oliveira M, Mesplède T, Xu H, Quan Y, Crooks PA, Wainberg MA. Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay. Journal of Medical Virology. PMID 27509184 DOI: 10.1002/Jmv.24660  0.279
2002 Crooks PA, Matheru J. Synthesis of endo-12-aminotricyclo[6.3.2.02,7]Trideca-2(7),3, 5-triene-12-exo-carboxylic acid: A novel, conformationally restricted phenylalanine analogue Synthetic Communications. 32: 3813-3819. DOI: 10.1081/Scc-120015400  0.279
1999 Dwoskin LP, Crooks PA, Teng L, Green TA, Bardo MT. Acute and chronic effects of nornicotine on locomotor activity in rats: altered response to nicotine. Psychopharmacology. 145: 442-51. PMID 10460322 DOI: 10.1007/S002130051079  0.279
1999 Swango JH, Bhatti BS, Qureshi MM, Crooks PA. A novel enantioselective synthesis of (S)-(-)- and (R)-(+)-nornicotine via alkylation of a chiral 2-hydroxy-3-pinanone ketimine template. Chirality. 11: 316-8. PMID 10224659 DOI: 10.1002/(Sici)1520-636X(1999)11:4<316::Aid-Chir9>3.0.Co;2-D  0.279
1982 Crooks PA, Sommerville R. The Synthesis And Analgesic Activities Of Some Spiro(Indan-1,3′-Pyrrolidine) Derivatives Designed As Rigid Analogs Of Profadol Cheminform. 13. DOI: 10.1002/Chin.198235196  0.278
1998 Worthen DR, Chien L, Tsuboi CP, Mu XY, Bartik MM, Crooks PA. L-Canavanine modulates cellular growth, chemosensitivity and P-glycoprotein substrate accumulation in cultured human tumor cell lines Cancer Letters. 132: 229-239. PMID 10397478 DOI: 10.1016/S0304-3835(98)00233-X  0.278
1986 Godin CS, Crooks PA. In vivo depletion of S-adenosyl-l-homocysteine and S-adenosyl-l-methionine in guinea pig lung after chronic S-(-)-nicotine administration Toxicology Letters. 31: 23-29. PMID 3715913 DOI: 10.1016/0378-4274(86)90190-6  0.277
2004 Zheng G, Dwoskin LP, Crooks PA. The preparation of 2-arylmethylidene-8-methyl-8-azabicyclo[3.2.1]octan-3- ones Synthetic Communications. 34: 1931-1942. DOI: 10.1081/Scc-120037905  0.277
2015 Jang DS, Penthala NR, Apostolov EO, Wang X, Fahmi T, Crooks PA, Basnakian AG. Novel high-throughput deoxyribonuclease 1 assay. Journal of Biomolecular Screening. 20: 202-11. PMID 25326282 DOI: 10.1177/1087057114555828  0.277
2015 Penthala NR, Crooks PA, Freeman ML, Sekhar KR. Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1. Bioorganic & Medicinal Chemistry. 23: 3681-6. PMID 25922180 DOI: 10.1016/J.Bmc.2015.04.018  0.276
1979 Crooks PA, Dreyer RN, Coward JK. Metabolism of S-adenosylhomocysteine and S-tubercidinylhomocysteine in neuroblastoma cells. Biochemistry. 18: 2601-9. PMID 444479 DOI: 10.1021/Bi00579A026  0.276
1990 Awad R, Hussain A, Crooks PA. Kinetics and mechanism of decomposition of N-chloro-α-amino acids Journal of the Chemical Society, Perkin Transactions 2. 1233-1238. DOI: 10.1039/P29900001233  0.276
2012 Janardhan B, Rajitha B, Crooks PA. Poly(4-vinylpyridinium)hydrogen sulfate: An efficient and recyclable Bronsted acid catalyst for the synthesis of fused 3,4-dihydropyrimidin-2(1H)-ones and thiones Journal of Saudi Chemical Society. DOI: 10.1016/J.Jscs.2012.10.007  0.276
2009 Vaddi HK, Banks SL, Chen J, Hammell DC, Crooks PA, Stinchcomb AL. Human skin permeation of 3-O-alkyl carbamate prodrugs of naltrexone. Journal of Pharmaceutical Sciences. 98: 2611-25. PMID 18972573 DOI: 10.1002/Jps.21594  0.276
2010 Vartak AP, Gabriela Deaciuc A, Dwoskin LP, Crooks PA. Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2. Bioorganic & Medicinal Chemistry Letters. 20: 3584-7. PMID 20494575 DOI: 10.1016/J.Bmcl.2010.04.117  0.276
2000 Dwoskin LP, Xu R, Ayers JT, Crooks PA. Recent developments in neuronal nicotinic acetylcholine receptor antagonists Expert Opinion On Therapeutic Patents. 10: 1561-1581. DOI: 10.1517/13543776.10.10.1561  0.275
1983 Hicks PE, Waldron C, Burn P, Crooks PA. alpha 2-Adrenoceptor agonist properties of exo- and endo-isomers of 2-amino-6,7,dihydroxybenzonorbornene designed as rigid catecholamines. The Journal of Pharmacy and Pharmacology. 35: 94-9. PMID 6131993 DOI: 10.1111/J.2042-7158.1983.Tb04276.X  0.275
2001 Miller DK, Wilkins LH, Bardo MT, Crooks PA, Dwoskin LP. Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanism. Psychopharmacology. 156: 469-76. PMID 11498725 DOI: 10.1007/S002130100747  0.275
1981 Shaker MS, Crooks PA, Damani LA. METABOLIC C‐ AND N‐OXIDATION AND N‐METHYLATION OF [2,614C] PYRIDINE IN VIVO: DETERMINATION OF URINARY METABOLITES BY H.P.L.C Journal of Pharmacy and Pharmacology. 33: 10P-10P. DOI: 10.1111/J.2042-7158.1981.Tb11669.X  0.275
1992 Reynolds RC, Crooks PA, Maddry JA, Shamim Akhtar M, Montgomery JA, Secrist JA. Synthesis of thymidine dimers containing internucleoside sulfonate and sulfonamide linkages Journal of Organic Chemistry. 57: 2983-2985. DOI: 10.1021/Jo00037A003  0.275
1996 Brock CP, Kottayil S, Butterfield DA, Crooks PA. A dihydromorphine-6-O-sulfate Acta Crystallographica Section C: Crystal Structure Communications. 52: 122-125. DOI: 10.1107/S0108270195010250  0.275
1993 Kadaba PK, Parmley G, Crooks PA, Agha B. Triazolines 24. permanganate-catalyzed low temperature thermolysis of 5-(4-pyridyl) substituted 1,2,3-triazolines [1] Journal of Heterocyclic Chemistry. 30: 1191-1195. DOI: 10.1002/Jhet.5570300505  0.275
2013 Meyer AC, Neugebauer NM, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo. Journal of Neurochemistry. 127: 187-98. PMID 23875705 DOI: 10.1111/Jnc.12373  0.275
2008 Malkawi AH, Al-Ghananeem AM, Crooks PA. Development of a GC-MS assay for the determination of fentanyl pharmacokinetics in rabbit plasma after sublingual spray delivery Aaps Journal. 10: 261-267. PMID 18459057 DOI: 10.1208/S12248-008-9031-X  0.274
2010 Reddy YT, Reddy PN, Reddy MN, Rajitha B, Crooks PA. Convenient and Scalable Process for the Preparation of Bupropion Hydrochloride via Efficient Bromination of m-Chloropropiophenone with N-Bromosuccinimide Synthetic Communications. 40: 1566-1573. DOI: 10.1080/00397910903097351  0.274
2009 Kiptoo PK, Paudel KS, Hammell DC, Pinninti RR, Chen J, Crooks PA, Stinchcomb AL. Transdermal delivery of bupropion and its active metabolite, hydroxybupropion: a prodrug strategy as an alternative approach. Journal of Pharmaceutical Sciences. 98: 583-94. PMID 18623203 DOI: 10.1002/Jps.21463  0.274
2007 Sonar VN, Venkatraj M, Parkin S, Crooks PA. Methyl 2,6-dihydroxy-3-nitrobenzoate Acta Crystallographica Section E Structure Reports Online. 63: o3227-o3227. DOI: 10.1107/S1600536807028589  0.274
2008 Albayati ZA, Dwoskin LP, Crooks PA. Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2024-9. PMID 18617603 DOI: 10.1124/Dmd.108.020354  0.274
2009 Dwoskin LP, Pivavarchyk M, Joyce BM, Neugebauer NM, Zheng G, Zhang Z, Bardo MT, Crooks PA. Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence. Nebraska Symposium On Motivation. Nebraska Symposium On Motivation. 55: 31-63. PMID 19013938 DOI: 10.1007/978-0-387-78748-0_4  0.273
2007 Stairs DJ, Neugebauer NM, Wei X, Boustany C, Hojahmat M, Cassis LA, Crooks PA, Dwoskin LP, Bardo MT. Effects of nornicotine enantiomers on intravenous S(-)-nicotine self-administration and cardiovascular function in rats. Psychopharmacology. 190: 145-55. PMID 17096082 DOI: 10.1007/S00213-006-0610-1  0.273
2017 Ford BM, Franks LN, Tai S, Fantegrossi WE, Stahl EL, Berquist MD, Cabanlong CV, Wilson CD, Penthala NR, Crooks PA, Prather PL. Characterization of Structurally Novel G Protein Biased CB1 Agonists: Implications for Drug Development. Pharmacological Research. PMID 28838808 DOI: 10.1016/J.Phrs.2017.08.008  0.273
2008 Madhav JV, Kuarm BS, Someshwar P, Rajitha B, Thirupathi Reddy YR, Crooks PA. Dipyridine cobalt chloride: a novel catalyst for the synthesis of coumarins via Pechmann condensation Journal of Chemical Research. 2008: 232-234. DOI: 10.3184/030823408X313997  0.273
1995 Cynkowski T, Cynkowska G, Ashton P, Crooks PA. Reaction of N-benzoyl amino acids with oxalyl chloride: A facile route to 4-substituted 2-phenyloxazole-5-carboxylates Journal of the Chemical Society, Chemical Communications. 2335-2336. DOI: 10.1039/C39950002335  0.273
1975 CROOKS PA, DEEKS T. ChemInform Abstract: REACTION OF NINHYDRIN WITH UREA AND N-SUBSTITUTED UREAS Chemischer Informationsdienst. 6: no-no. DOI: 10.1002/Chin.197549268  0.273
2005 Valiveti S, Hammell DC, Paudel KS, Hamad MO, Crooks PA, Stinchcomb AL. In vivo evaluation of 3-O-alkyl ester transdermal prodrugs of naltrexone in hairless guinea pigs. Journal of Controlled Release : Official Journal of the Controlled Release Society. 102: 509-20. PMID 15653167 DOI: 10.1016/J.Jconrel.2004.10.005  0.272
1987 Dannan H, Khawam MN, Bogardus JB, Hussain AA, Crooks PA. S-acylation of cysteine by O-acetylsalicylic anhydride: a possible mechanism for aspirin hypersensitivity? Journal of Pharmaceutical Sciences. 75: 1081-4. PMID 3820103 DOI: 10.1002/Jps.2600751112  0.272
1982 Crooks PA, DeSimone F, Ramundo E. Synthesis of 2,3,3a,8a‐tetrahydroindeno[2,1‐b]pyrrole derivatives Journal of Heterocyclic Chemistry. 19: 1433-1436. DOI: 10.1002/Jhet.5570190635  0.272
2006 Crooks PA, Kottayil SG, Al-Ghananeem AM, Byrn SR, Butterfield DA. Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorganic & Medicinal Chemistry Letters. 16: 4291-5. PMID 16777416 DOI: 10.1016/J.Bmcl.2006.05.060  0.272
2008 Jenkins C, Hewamana S, Gilkes AF, Neelakantan S, Crooks P, Mills K, Pepper CJ, Burnett AK. Nuclear factor-kappaB as a potential therapeutic target for the novel cytotoxic agent LC-1 in acute myeloid leukaemia British Journal of Haematology. 143: 661-671. PMID 19036014 DOI: 10.1111/J.1365-2141.2008.07392.X  0.271
2019 Ford BM, Cabanlong CV, Tai S, Franks LN, Penthala NR, Crooks PA, Prather PL, Fantegrossi WE. Reduced tolerance and asymmetrical cross-tolerance to effects of indole quinuclidinone analogue PNR-4-20, a G protein biased CB1R agonist in mice: comparisons with Δ9-THC and JWH-018. The Journal of Pharmacology and Experimental Therapeutics. PMID 30833484 DOI: 10.1124/Jpet.118.252965  0.271
1997 Crooks PA, Dwoskin LP. Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking. Biochemical Pharmacology. 54: 743-53. PMID 9353128 DOI: 10.1016/S0006-2952(97)00117-2  0.271
2012 Alvers KM, Beckmann JS, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats. Psychopharmacology. 224: 255-62. PMID 22638813 DOI: 10.1007/S00213-012-2748-3  0.27
2005 Zheng G, Dwoskin LP, Deaciuc AG, Zhu J, Jones MD, Crooks PA. Lobelane analogues as novel ligands for the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry. 13: 3899-909. PMID 15911306 DOI: 10.1016/J.Bmc.2005.04.013  0.27
1981 Damani LA, Crooks PA, Cowan DA. Metabolism of metyrapone: 2—chromatographic and mass spectral properties of the N‐oxides of metyrapone and metyrapol Biological Mass Spectrometry. 8: 270-277. PMID 7260343 DOI: 10.1002/Bms.1200080609  0.27
2011 Pei S, Callahan K, Minhajuddin M, Balys M, Neering S, Corbett C, Becker MW, Liesveld JL, Hagen F, Friedman AE, Crooks P, Jordan CT. Targeting Redox Homeostasis As a Means to Selectively Eradicate Primary Human Leukemia Cells, Blood. 118: 3506-3506. DOI: 10.1182/Blood.V118.21.3506.3506  0.27
1999 Bardo MT, Green TA, Crooks PA, Dwoskin LP. Nornicotine is self-administered intravenously by rats. Psychopharmacology. 146: 290-6. PMID 10541729 DOI: 10.1007/S002130051119  0.27
1983 Benghiat E, Crooks PA. Synthesis of S‐5‐pyrrolo[2,3‐b]pyridinemethyl and S‐5‐ and S‐6‐pyrrolo[2,3‐d]pyridinemethyl derivatives of 5′‐deoxy‐5′‐thioadenosine Journal of Heterocyclic Chemistry. 20: 677-679. DOI: 10.1002/Jhet.5570200334  0.269
2005 Huang X, Zheng F, Crooks PA, Dwoskin LP, Zhan CG. Modeling multiple species of nicotine and deschloroepibatidine interacting with alpha4beta2 nicotinic acetylcholine receptor: from microscopic binding to phenomenological binding affinity. Journal of the American Chemical Society. 127: 14401-14. PMID 16218635 DOI: 10.1021/Ja052681+  0.269
2003 Wei X, Crooks PA. An improved synthesis of β-Nicotyrine from the dehydrogenation of nicotine: Comparison of conventional and microwave-assisted reactions Synthetic Communications. 33: 3305-3315. DOI: 10.1081/Scc-120023988  0.269
2013 Sonar VN, Parkin S, Crooks PA. (E)-3-(Benzo[b]thio­phen-2-yl)-2-(3,4,5-trimethoxy­phen­yl)acrylonitrile and (Z)-3-(benzo[b]thio­phen-2-yl)-2-(3,4-dimethoxy­phen­yl)acrylonitrile. Corrigendum Acta Crystallographica Section C-Crystal Structure Communications. 69: 454-454. DOI: 10.1107/S0108270113007129  0.268
2010 Zheng G, Zhang Z, Lockman PR, Geldenhuys WJ, Allen DD, Dwoskin LP, Crooks PA. Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry Letters. 20: 3208-10. PMID 20462759 DOI: 10.1016/J.Bmcl.2010.04.098  0.268
2018 Maggio SE, Saunders MA, Nixon K, Prendergast MA, Zheng G, Crooks PA, Dwoskin LP, Bell RL, Bardo MT. An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic α6β2* antagonist r-bPiDI. Drug and Alcohol Dependence. 193: 154-161. PMID 30384323 DOI: 10.1016/J.Drugalcdep.2018.09.008  0.268
1987 Houdi AA, Crooks PA, Van Loon GR, Schubert CA. A simple and sensitive determination of histamine and N tau-methylhistamine in biological fluids by high-performance liquid chromatography with electrochemical detection. Journal of Pharmaceutical Sciences. 76: 398-401. PMID 3656102 DOI: 10.1002/Jps.2600760512  0.268
1988 GAIROLA C, GODIN CS, HOUDI AA, CROOKS PA. Inhibition of histamine N‐methyltransferase activity in guinea‐pig pulmonary alveolar macrophages by nicotine Journal of Pharmacy and Pharmacology. 40: 724-726. PMID 2907542 DOI: 10.1111/J.2042-7158.1988.Tb07004.X  0.268
2007 Sonar VN, Venkatraj M, Parkin S, Crooks PA. Benzyl 2,6-dihydroxy-3-nitrobenzoate Acta Crystallographica Section E Structure Reports Online. 63: o3226-o3226. DOI: 10.1107/S1600536807028541  0.268
2012 Beckmann JS, Denehy ED, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats. Psychopharmacology. 220: 395-403. PMID 21938414 DOI: 10.1007/S00213-011-2488-9  0.267
2008 Reddy YT, Reddy PN, Reddy PR, Crooks PA. Tetrabenzylpyrophosphate: An Efficient Catalyst for the Synthesis of Carboxamides from Carboxylic Acids and Amines Chemistry Letters. 37: 528-529. DOI: 10.1246/Cl.2008.528  0.267
2009 Holtman JR, Crooks PA, Johnson-Hardy JK, Wala EP. The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain. Pharmacology, Biochemistry, and Behavior. 94: 352-62. PMID 19800911 DOI: 10.1016/J.Pbb.2009.09.017  0.267
2006 Holtman J, Johnson J, Crooks P, Wala E. (768) The Journal of Pain. 7: S43. DOI: 10.1016/J.Jpain.2006.01.170  0.266
2006 Wala E, Griffin W, Crooks P, Holtman J. (764) The Journal of Pain. 7: S42. DOI: 10.1016/J.Jpain.2006.01.166  0.266
2006 St. Clair W, Sun Y, St. Clair D, Batinic-Haberle I, Fang F, Kudrimoti M, Warren G, Crooks P. 2688 International Journal of Radiation Oncology*Biology*Physics. 66: S592. DOI: 10.1016/J.Ijrobp.2006.07.1103  0.266
1978 Crooks PA, Breakefield XO, Sulens CH, Castiglione CM, Coward JK. Extensive conjugation of dopamine (3,4-dihydroxyphenethylamine) metabolites in cultured human skin fibroblasts and rat hepatoma cells. The Biochemical Journal. 176: 187-96. PMID 569477 DOI: 10.1042/Bj1760187  0.266
2015 Jang DS, Penthala NR, Apostolov EO, Wang X, Crooks PA, Basnakian AG. Novel cytoprotective inhibitors for apoptotic endonuclease G. Dna and Cell Biology. 34: 92-100. PMID 25401220 DOI: 10.1089/Dna.2014.2530  0.266
2004 Gali-Muhtasib HU, Abou Kheir WG, Kheir LA, Darwiche N, Crooks PA. Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anti-Cancer Drugs. 15: 389-99. PMID 15057144 DOI: 10.1097/00001813-200404000-00012  0.266
1985 Crooks PA, Krechniak JW, Olson JW, Gillespie MN. High-performance liquid chromatographic analysis of pulmonary metabolites of Leu- and Met-enkephalins in isolated perfused rat lung Journal of Pharmaceutical Sciences. 74: 1010-1012. PMID 4067842 DOI: 10.1002/Jps.2600740923  0.266
2014 Nickell JR, Beckmann J, Denehy E, Siripurapu K, Culver J, Bardo M, Crooks P, Dwoskin LP. Preclinical evaluation of JPC-077 as a novel treatment for methamphetamine abuse Drug and Alcohol Dependence. 140: e160-e161. DOI: 10.1016/J.Drugalcdep.2014.02.453  0.266
1998 Aziz SM, Yatin M, Worthen DR, Lipke DW, Crooks PA. A novel technique for visualizing the intracellular localization and distribution of transported polyamines in cultured pulmonary artery smooth muscle cells. Journal of Pharmaceutical and Biomedical Analysis. 17: 307-20. PMID 9638584 DOI: 10.1016/S0731-7085(98)00016-8  0.265
2007 Sun Y, St Clair DK, Fang F, Warren GW, Rangnekar VM, Crooks PA, St Clair WH. The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN. Molecular Cancer Therapeutics. 6: 2477-86. PMID 17876045 DOI: 10.1158/1535-7163.Mct-07-0186  0.265
2007 Sekhar KR, Sonar VN, Muthusamy V, Sasi S, Laszlo A, Sawani J, Horikoshi N, Higashikubo R, Bristow RG, Borrelli MJ, Crooks PA, Lepock JR, Roti Roti JL, Freeman ML. Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway. Cancer Research. 67: 695-701. PMID 17234780 DOI: 10.1158/0008-5472.Can-06-3212  0.264
2010 Matharu J, Oki J, Worthen DR, Smith QR, Crooks PA. Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier. Bioorganic & Medicinal Chemistry Letters. 20: 3688-91. PMID 20466543 DOI: 10.1016/J.Bmcl.2010.04.086  0.264
2009 Vartak AP, Nickell JR, Chagkutip J, Dwoskin LP, Crooks PA. Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2). Journal of Medicinal Chemistry. 52: 7878-82. PMID 19691331 DOI: 10.1021/Jm900770H  0.264
2016 Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, et al. Rational Design of a Parthenolide-based Drug Regimen that Selectively Eradicates Acute Myelogenous Leukemia Stem Cells. The Journal of Biological Chemistry. PMID 27573247 DOI: 10.1074/Jbc.M116.750653  0.264
2020 Bowroju SK, Mainali N, Ayyadevara S, Penthala NR, Krishnamachari S, Kakraba S, Reis RJS, Crooks PA. Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation. Molecules (Basel, Switzerland). 25. PMID 32784464 DOI: 10.3390/Molecules25163610  0.263
1981 CROOKS PA, DAMANI LA, COWAN DA. Synthesis of N‐oxide derivatives of metyrapone and their detection as in vitro metabolites Journal of Pharmacy and Pharmacology. 33: 309-312. PMID 6116779 DOI: 10.1111/J.2042-7158.1981.Tb13786.X  0.263
1978 CROOKS PA, ROSENBERG HE. ChemInform Abstract: SYNTHESIS OF SPIRO(TETRALIN-2,2′-PYRROLIDINE) AND SPIRO(INDAN-2,2′-PYRROLIDINE) DERIVATIVES AS POTENTIAL ANALGESICS Chemischer Informationsdienst. 9. DOI: 10.1002/Chin.197848220  0.263
2013 Venkateswaran A, Friedman DB, Walsh AJ, Skala MC, Sasi S, Rachakonda G, Crooks PA, Freeman ML, Sekhar KR. The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Investigational New Drugs. 31: 535-44. PMID 23054211 DOI: 10.1007/S10637-012-9884-9  0.262
1988 Crooks PA, Godin CS. N‐Methylation of nicotine enantiomers by human liver cytosol Journal of Pharmacy and Pharmacology. 40: 153-154. PMID 2897456 DOI: 10.1111/J.2042-7158.1988.Tb05207.X  0.262
2008 Crean CD, Zhang G, Pollok KE, Sinn AL, Crooks PA, Farag S, Abonour R, Suvannasankha A. Dimethylaminoparthenolide (DMAPT) in Multiple Myeloma Blood. 112: 3672-3672. DOI: 10.1182/Blood.V112.11.3672.3672  0.262
2018 Flores-Lopez G, Moreno-Lorenzana D, Ayala-Sanchez M, Aviles-Vazquez S, Torres-Martinez H, Crooks PA, Guzman ML, Mayani H, Chávez-González A. Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species. Journal of Cellular and Molecular Medicine. PMID 30079458 DOI: 10.1111/Jcmm.13755  0.262
2015 Saeed LM, Mahmood M, Xu Y, Nima ZA, Kannarpady GK, Bratton SM, Dervishi E, Casciano D, Ali S, Crooks PA, Radominska-Pandya A, Biris AS. Nanodelivery of gambogic acid by functionalized graphene enhances inhibition of cell proliferation and induces G0/G1 cell cycle arrest in cervical, ovarian, and prostate cancer cells Rsc Advances. 5: 44022-44030. DOI: 10.1039/C5Ra00833F  0.262
2006 Huang X, Zheng F, Chen X, Crooks PA, Dwoskin LP, Zhan CG. Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions. Journal of Medicinal Chemistry. 49: 7661-74. PMID 17181149 DOI: 10.1021/Jm0606701  0.261
2009 Venu Madhav J, Thirupathi Reddy Y, Narsimha Reddy P, Nikhil Reddy M, Kuarm S, Crooks PA, Rajitha B. Cellulose sulfuric acid: An efficient biodegradable and recyclable solid acid catalyst for the one-pot synthesis of aryl-14H-dibenzo[a.j]xanthenes under solvent-free conditions Journal of Molecular Catalysis a: Chemical. 304: 85-87. DOI: 10.1016/J.Molcata.2009.01.028  0.26
2000 Green TA, Phillips SB, Crooks PA, Dwoskin LP, Bardo MT. Nornicotine pretreatment decreases intravenous nicotine self-administration in rats. Psychopharmacology. 152: 289-94. PMID 11105939 DOI: 10.1007/S002130000524  0.26
2006 Zheng G, Dwoskin LP, Crooks PA. Vesicular monoamine transporter 2: role as a novel target for drug development. The Aaps Journal. 8: E682-92. PMID 17233532 DOI: 10.1208/Aapsj080478  0.258
1995 Bass M, Harper L, Rosenthal GA, Phuket SN, Crooks PA. Large-scale production and chemical characterization of the protective higher plant allelochemicals: l-Canavanine and l-canaline Biochemical Systematics and Ecology. 23: 717-721. DOI: 10.1016/0305-1978(95)00076-3  0.258
2014 Banothu J, Vaarla K, Bavantula R, Crooks PA. Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature Chinese Chemical Letters. 25: 172-175. DOI: 10.1016/J.Cclet.2013.10.001  0.257
2007 Yip-Schneider MT, Wu H, Ralstin M, Yiannoutsos C, Crooks PA, Neelakantan S, Noble S, Nakshatri H, Sweeney CJ, Schmidt CM. Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo. Molecular Cancer Therapeutics. 6: 1736-44. PMID 17541034 DOI: 10.1158/1535-7163.Mct-06-0794  0.257
2017 Kangiser MM, Dwoskin LP, Zheng G, Crooks PA, Stairs DJ. Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats. Behavioural Pharmacology. PMID 28863003 DOI: 10.1097/Fbp.0000000000000340  0.257
2011 Nasim S, Pei S, Hagen FK, Jordan CT, Crooks PA. Melampomagnolide B: a new antileukemic sesquiterpene. Bioorganic & Medicinal Chemistry. 19: 1515-9. PMID 21273084 DOI: 10.1016/J.Bmc.2010.12.045  0.257
1985 Mousa S, van Loon GR, Houdi AA, Crooks PA. High-performance liquid chromatography with electrochemical detection for the determination of nicotine and N-methylnicotinium ion Journal of Chromatography A. 347: 405-410. PMID 4077941 DOI: 10.1016/S0021-9673(01)95514-1  0.257
2005 Valiveti S, Paudel KS, Hammell DC, Hamad MO, Chen J, Crooks PA, Stinchcomb AL. In vitro/in vivo correlation of transdermal naltrexone prodrugs in hairless guinea pigs. Pharmaceutical Research. 22: 981-9. PMID 15948042 DOI: 10.1007/S11095-005-4593-0  0.256
2015 Holt JC, Kewin K, Jordan PM, Cameron P, Klapczynski M, McIntosh JM, Crooks PA, Dwoskin LP, Lysakowski A. Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 3625-43. PMID 25716861 DOI: 10.1523/Jneurosci.3388-14.2015  0.256
2013 Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, ... ... Crooks PA, et al. Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells. The Journal of Biological Chemistry. 288: 33542-58. PMID 24089526 DOI: 10.1074/Jbc.M113.511170  0.256
1993 Dwoskin LP, Buxton ST, Jewell AL, Crooks PA. S(-)-nornicotine increases dopamine release in a calcium-dependent manner from superfused rat striatal slices. Journal of Neurochemistry. 60: 2167-74. PMID 8492124 DOI: 10.1111/J.1471-4159.1993.Tb03502.X  0.256
2009 Vartak AP, Crooks PA. A scalable, enantioselective synthesis of the r2-adrenergic agonist, lofexidine Organic Process Research and Development. 13: 415-419. DOI: 10.1021/Op8002689  0.256
1988 POOL WF, CROOKS PA. Biotransformation of Primary Nicotine Metabolites: Metabolism of R‐(+)‐[3H‐N′‐CH3; 14C‐N‐CH3] N‐Methylnicotinium Acetate—The Use of Double Isotope Studies to Determine the In‐vivo Stability of the N‐Methyl Groups of N‐Methylnicotinium Ion Journal of Pharmacy and Pharmacology. 40: 758-762. PMID 2907553 DOI: 10.1111/J.2042-7158.1988.Tb05167.X  0.255
2013 Xu Y, Fang F, Miriyala S, Crooks PA, Oberley TD, Chaiswing L, Noel T, Holley AK, Zhao Y, Kiningham KK, Clair DK, Clair WH. KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells. Cancer Research. 73: 4406-17. PMID 23674500 DOI: 10.1158/0008-5472.Can-12-4297  0.255
1984 Waigh RD, Deeks T, Crooks PA. Leucine enkephalin analogues containing a conformationally restrained N‐terminal amino acid residue Journal of Pharmaceutical Sciences. 73: 457-460. PMID 6726628 DOI: 10.1002/Jps.2600730408  0.255
2018 Maggio SE, Saunders MA, Baxter TA, Nixon K, Prendergast MA, Zheng G, Crooks P, Dwoskin LP, Slack RD, Newman AH, Bell RL, Bardo MT. Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats. Psychopharmacology. PMID 29455292 DOI: 10.1007/S00213-018-4853-4  0.255
2013 Wilmouth CE, Zheng G, Crooks PA, Dwoskin LP, Bardo MT. Oral administration of GZ-793A, a VMAT2 inhibitor, decreases methamphetamine self-administration in rats. Pharmacology, Biochemistry, and Behavior. 112: 29-33. PMID 24075974 DOI: 10.1016/J.Pbb.2013.09.006  0.255
2010 Yerramreddy TR, Milewski M, Penthala NR, Stinchcomb AL, Crooks PA. Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery. Bioorganic & Medicinal Chemistry Letters. 20: 3280-3. PMID 20451376 DOI: 10.1016/J.Bmcl.2010.04.049  0.255
2011 Kuarm BS, Madhav JV, Rajitha B, Reddy YT, Reddy PN, Crooks PA. Cellulose Sulfuric Acid: Novel and Efficient Biodegradable and Recyclable Acid Catalyst for the Solid-State Synthesis of Thiadiazolo Benzimidazoles Synthetic Communications. 41: 662-669. DOI: 10.1080/00397911003632899  0.254
2011 Kuarm BS, Madhav JV, Laxmi SV, Rajitha B, Reddy YT, Reddy PN, Crooks PA. Cellulose Sulfuric Acid: An Efficient Biodegradable and Recyclable Solid Acid Catalyst for the Synthesis of 1-Oxo-hexahydroxanthene Synthetic Communications. 41: 1719-1724. DOI: 10.1080/00397911.2010.492076  0.253
1975 CROOKS PA. ChemInform Abstract: REACTION OF NINHYDRIN WITH N-ALKYLACETAMIDES Chemischer Informationsdienst. 6. DOI: 10.1002/Chin.197519243  0.253
1981 CROOKS PA, DEEKS T, DESIMONE F, RAMUNDO E. ChemInform Abstract: SYNTHESIS OF ISOMERIC 2-AMINO-1,3-DIHYDROXYINDANES FROM NINHYDRIN Chemischer Informationsdienst. 12. DOI: 10.1002/Chin.198141169  0.253
2013 Kuarm BS, Crooks PA, Rajitha B. An expeditious synthesis of quinoxalines by using biodegradable cellulose sulfuric acid as a solid acid catalyst Green Chemistry Letters and Reviews. 6: 228-232. DOI: 10.1080/17518253.2012.752041  0.253
2020 Liu X, Gao Z, Fu Q, Song L, Zhang P, Zhang X, Hendrickson H, Crooks PA, Zhou D, Zheng G. Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production. Bioorganic & Medicinal Chemistry. 115498. PMID 32291146 DOI: 10.1016/J.Bmc.2020.115498  0.253
1996 Houdi AA, Kottayil S, Crooks PA, Butterfield DA. 3-O-Acetylmorphine-6-O-Sulfate: A potent, centrally acting morphine derivative Pharmacology Biochemistry and Behavior. 53: 665-671. PMID 8866970 DOI: 10.1016/0091-3057(95)02067-5  0.253
2007 Malkawi AH, Al-Ghananeem AM, Nasim S, de Leon J, Crooks PA. An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma. Journal of Pharmaceutical and Biomedical Analysis. 45: 120-124. PMID 17706392 DOI: 10.1016/J.Jpba.2007.06.024  0.253
2010 Nasim S, Vartak AP, Pierce WM, Taylor KG, Smith N, Crooks PA. 3-O-phosphate ester conjugates of 17-β-O-{1-[2-carboxy-(2-hydroxy-4-methoxy-3-carboxamido)anilido]ethyl}1,3,5(10)-estratriene as novel bone-targeting agents. Bioorganic & Medicinal Chemistry Letters. 20: 7450-3. PMID 21055931 DOI: 10.1016/J.Bmcl.2010.10.023  0.252
1998 Aziz SM, Worthen DR, Yatin M, Ain KB, Crooks PA. A unique interaction between polyamine and multidrug resistance (P-glycoprotein) transporters in cultured Chinese hamster ovary cells transfected with mouse mdr-1 gene Biochemical Pharmacology. 56: 181-187. PMID 9698071 DOI: 10.1016/S0006-2952(98)00132-4  0.252
1983 Benghiat E, Crooks PA. Reaction of 2‐acetamido‐3,7‐dihydropyrrolo[2,3‐d]pyrimidin‐4‐one with dimethylamine and formaldehyde. Formation of two isomeric mannich bases Journal of Heterocyclic Chemistry. 20: 1023-1025. DOI: 10.1002/Jhet.5570200436  0.252
2008 Yip-Schneider MT, Wu H, Njoku V, Ralstin M, Holcomb B, Crooks PA, Neelakantan S, Sweeney CJ, Schmidt CM. Effect of celecoxib and the novel anti-cancer agent, dimethylamino-parthenolide, in a developmental model of pancreatic cancer. Pancreas. 37: e45-53. PMID 18815538 DOI: 10.1097/Mpa.0B013E318172B4Dd  0.251
2017 Mendonca MS, Turchan WT, Day ME, Watson CN, Estabrook NC, Chin-Sinex H, Shapiro JB, Imasuen I, Rangel G, Gilley DP, Huda N, Crooks PA, Shapiro RH. (P001) DMAPT Inhibits NF-KAPPA B Activity and Increases Sensitivity of Prostate Cancer Cells to X-Rays In Vitro and in Tumor Xenografts In Vivo International Journal of Radiation Oncology*Biology*Physics. 98: E16. DOI: 10.1016/J.Ijrobp.2017.02.099  0.251
2004 Zheng G, Dwoskin LP, Crooks PA. Indirect trapping of the retroconjugate addition reaction intermediate involved in the epimerization of lobeline: application to the synthesis of (-)-sedamine. The Journal of Organic Chemistry. 69: 8514-7. PMID 15549833 DOI: 10.1021/Jo048848J  0.251
2011 Estabrook NC, Chin-Sinex H, Borgmann AJ, Dhaemers RM, Shapiro RH, Gilley D, Huda N, Crooks P, Sweeney C, Mendonca MS. Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays Free Radical Biology and Medicine. 51: 2249-2258. PMID 22019440 DOI: 10.1016/J.Freeradbiomed.2011.09.029  0.251
2007 Neugebauer NM, Harrod SB, Stairs DJ, Crooks PA, Dwoskin LP, Bardo MT. Lobelane decreases methamphetamine self-administration in rats. European Journal of Pharmacology. 571: 33-8. PMID 17612524 DOI: 10.1016/J.Ejphar.2007.06.003  0.251
2010 Nasim S, Vartak AP, Pierce WM, Grant Taylor K, Crooks PA. Improved and scalable synthetic route to the synthon 17-β-(2- Carboxyethyl)-1,3,5(10)-estratriene: An important intermediate in the synthesis of bone-targeting estrogens Synthetic Communications. 40: 772-781. DOI: 10.1080/00397910903013796  0.25
1988 Chien C‐, Diana JN, Crooks PA. High‐performance liquid chromatography with electrochemical detection for the determination of nicotine in plasma Journal of Pharmaceutical Sciences. 77: 277-279. PMID 3373433 DOI: 10.1002/Jps.2600770319  0.25
2009 Neelakantan S, Surjawan I, Karacelik H, Hicks CL, Crooks PA. Synthesis of novel isoluminol probes and their use in rapid bacterial assays. Bioorganic & Medicinal Chemistry Letters. 19: 5722-6. PMID 19700327 DOI: 10.1016/J.Bmcl.2009.08.004  0.25
2007 Vegeler RC, Yip-Schneider MT, Ralstin M, Wu H, Crooks PA, Neelakantan S, Nakshatri H, Sweeney CJ, Schmidt CM. Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancer. The Journal of Surgical Research. 143: 169-76. PMID 17950089 DOI: 10.1016/J.Jss.2007.08.007  0.25
2013 Banothu J, Gali R, Velpula R, Bavantula R, Crooks PA. An Eco-Friendly Improved Protocol for the Synthesis of Bis(3-indolyl)methanes Using Poly(4-vinylpyridinium)hydrogen Sulfate as Efficient, Heterogeneous, and Recyclable Solid Acid Catalyst. Isrn Organic Chemistry. 2013: 616932. PMID 24052864 DOI: 10.1155/2013/616932  0.25
2008 Holtman JR, Crooks PA, Johnson-Hardy JK, Hojomat M, Kleven M, Wala EP. Effects of norketamine enantiomers in rodent models of persistent pain. Pharmacology, Biochemistry, and Behavior. 90: 676-85. PMID 18586315 DOI: 10.1016/J.Pbb.2008.05.011  0.25
2013 Venkateswaran A, Levic DS, Melville DB, Sekhar KR, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML. Abstract 384: NADH oxidase, Enox1 activity, is required for vasculogenesis in Zebrafish. Cancer Research. 73: 384-384. DOI: 10.1158/1538-7445.Am2013-384  0.249
2015 Sau A, Lau R, Nolan E, Crooks PA, Visvader JE, Pratt CM. Abstract P5-11-04: Inhibition of alternative NF-κB activity prevents the expansion of genetically unstable progenitor cells in BRCA1-deficient mammary glands Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P5-11-04  0.249
2007 Howard-Sparks M, Al-Ghananeem AM, Crooks PA, Pearson AP. A novel chemical delivery system comprising an ocular sustained release formulation of a 3α, 17α, 21-trihydroxy-5β-pregnan-20-one-BIS- 5-flourouracil codrug Drug Development and Industrial Pharmacy. 33: 677-682. PMID 17613031 DOI: 10.1080/03639040601134108  0.249
2017 Mendonca MS, Turchan WT, Alpuche ME, Watson CN, Estabrook NC, Chin-Sinex H, Shapiro JB, Imasuen-Williams IE, Rangel G, Gilley DP, Huda N, Crooks PA, Shapiro RH. DMAPT inhibits NF-κB activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo. Free Radical Biology & Medicine. PMID 28782644 DOI: 10.1016/J.Freeradbiomed.2017.08.001  0.249
2009 McIntosh J, Dwoskin L, Crooks P, Holtman J. GZ556A and ZZ204G are novel small molecule antagonists of α9α10 nAChRs and are analgesic in rats Biochemical Pharmacology. 78: 921. DOI: 10.1016/J.Bcp.2009.06.084  0.248
2009 Reddy PN, Reddy YT, Reddy MN, Rajitha B, Crooks P. Cellulose Sulfuric Acid: An Efficient Biodegradable and Recyclable Solid Acid Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidine-2(1H)-ones Synthetic Communications. 39: 1257-1263. DOI: 10.1080/00397910802517871  0.248
2012 Holcomb BK, Yip-Schneider MT, Waters JA, Beane JD, Crooks PA, Schmidt CM. Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 16: 1333-40. PMID 22618517 DOI: 10.1007/S11605-012-1913-7  0.248
2005 Cynkowska G, Cynkowski T, Al-Ghananeem AM, Al-Ghananeem AA, Guo H, Ashton P, Crooks PA. Novel antiglaucoma prodrugs and codrugs of ethacrynic acid. Bioorganic & Medicinal Chemistry Letters. 15: 3524-7. PMID 15990301 DOI: 10.1016/J.Bmcl.2005.05.128  0.248
2008 Reddy YT, Reddy PR, Reddy MN, Rajitha B, Crooks PA. Sulfamic Acid: An Efficient, Cost-Effective, and Reusable Solid Acid Catalyst for the Synthesis of 1,8-Naphthyridines Under Solvent-Free Heating and Microwave Irradiation Synthetic Communications. 38: 3201-3207. DOI: 10.1080/00397910802109281  0.248
2015 Adeneye AA, Crooks PA. Weight losing, antihyperlipidemic and cardioprotective effects of the alkaloid fraction of Hunteria umbellata seed extract on normal and triton-induced hyperlipidemic rats Asian Pacific Journal of Tropical Biomedicine. 5: 387-394. DOI: 10.1016/S2221-1691(15)30374-9  0.248
2015 Biermann M, Zheng G, Hojahmat M, Moskalev NV, Crooks PA. Asymmetric synthesis of (S)- and (R)-norketamine via Sharpless asymmetric dihydroxylation/Ritter amination sequence Tetrahedron Letters. 56: 2608-2610. DOI: 10.1016/J.Tetlet.2015.04.050  0.248
2008 Hewamana S, Alghazal S, Lin TT, Clement M, Jenkins C, Guzman ML, Jordan CT, Neelakantan S, Crooks PA, Burnett AK, Pratt G, Fegan C, Rowntree C, Brennan P, Pepper C. The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood. 111: 4681-9. PMID 18227347 DOI: 10.1182/Blood-2007-11-125278  0.248
2015 Burnett RM, Craven KE, Krishnamurthy P, Goswami CP, Badve S, Crooks P, Mathews WP, Bhat-Nakshatri P, Nakshatri H. Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells. Oncotarget. 6: 12682-96. PMID 25926557 DOI: 10.18632/Oncotarget.3707  0.248
2010 Sun Y, St Clair DK, Xu Y, Crooks PA, St Clair WH. A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Research. 70: 2880-90. PMID 20233868 DOI: 10.1158/0008-5472.Can-09-4572  0.248
1990 Tawfig FA, Dittert L, Hussain A, Crooks PA. Rearrangement of O-acetylsalicylamides via intramolecular O-to-N transacylation: Rate enhancement by an adjacent carboxylic acid group Journal of Pharmaceutical Sciences. 79: 651. PMID 2398477 DOI: 10.1002/Jps.2600790724  0.247
2004 Ko K, Wei X, Crooks PA, Koprowski H. Elimination of alkaloids from plant-derived human monoclonal antibody Journal of Immunological Methods. 286: 79-85. PMID 15087223 DOI: 10.1016/J.Jim.2003.11.015  0.247
2007 Al-Ghananeem AM, Malkawi AH, Crooks PA. Scopolamine sublingual spray: an alternative route of delivery for the treatment of motion sickness. Drug Development and Industrial Pharmacy. 33: 577-82. PMID 17520450 DOI: 10.1080/03639040600943848  0.247
2013 Banothu J, Bavantula R, Crooks PA. Poly(4-Vinylpyridinium)Hydrogen Sulfate Catalyzed an Efficient and Ecofriendly Protocol for the One-Pot Multicomponent Synthesis of 1,8-Acridinediones in Aqueous Medium Journal of Chemistry. 2013: 1-6. DOI: 10.1155/2013/850254  0.246
1993 Hussain AA, Awad R, Crooks PA, Dittert LW. Chloramine-T in Radiolabeling Techniques. I. Kinetics and Mechanism of the Reaction between Chloramine-T and Amino Acids Analytical Biochemistry. 214: 495-499. PMID 8109739 DOI: 10.1006/Abio.1993.1528  0.246
2003 Balbo PB, Patel CN, Sell KG, Adcock RS, Neelakantan S, Crooks PA, Oliveira MA. Spectrophotometric and Steady-State Kinetic Analysis of the Biosynthetic Arginine Decarboxylase of Yersinia pestis Utilizing Arginine Analogues as Inhibitors and Alternative Substrates Biochemistry. 42: 15189-15196. PMID 14690429 DOI: 10.1021/Bi0344127  0.246
2014 Venkateswaran A, Sekhar KR, Levic DS, Melville DB, Clark TA, Rybski WM, Walsh AJ, Skala MC, Crooks PA, Knapik EW, Freeman ML. The NADH oxidase ENOX1, a critical mediator of endothelial cell radiosensitization, is crucial for vascular development. Cancer Research. 74: 38-43. PMID 24247717 DOI: 10.1158/0008-5472.Can-13-1981  0.246
2011 Wala E, Crooks P, McIntosch J, Elliott M, Walter J, Holtman J. Novel small molecule alpha9 alpha10 nicotinic receptor antagonist prevents and reverses chemotherapy evoked neuropathic pain in rats The Journal of Pain. 12: P34. DOI: 10.1016/J.Jpain.2011.02.136  0.246
1973 CROOKS PA, ROBINSON B. Conopharyngine pseudoindoxyl, a new alkaloid from Tabernamontana pachysiphon Stapf, var cumminsii (Stapf.) H. Huber Journal of Pharmacy and Pharmacology. 25: 820-823. PMID 4149744 DOI: 10.1111/J.2042-7158.1973.Tb09948.X  0.246
2005 Ayers JT, Sonar VN, Parking S, Dwoskin LP, Crooks PA. A (1R,2R,5R)-(+)-2α-hydroxypinan-3-one ketimine Acta Crystallographica Section E: Structure Reports Online. 61: o2682-o2684. DOI: 10.1107/S1600536805023287  0.245
2015 Nakshatri H, Appaiah HN, Anjanappa M, Gilley D, Tanaka H, Badve S, Crooks PA, Mathews W, Sweeney C, Bhat-Nakshatri P. NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death & Disease. 6: e1608. PMID 25611383 DOI: 10.1038/Cddis.2014.569  0.245
1997 Bardo MT, Bevins RA, Klebaur JE, Crooks PA, Dwoskin LP. (-)-Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats. Pharmacology, Biochemistry, and Behavior. 58: 1083-7. PMID 9408217 DOI: 10.1016/S0091-3057(97)00303-1  0.245
2009 Nasim S, Crooks PA. N-Chlorosuccinimide is a convenient oxidant for the synthesis of 2,4-disubstituted 1,2,4-thiadiazolidine-3,5-diones Tetrahedron Letters. 50: 257-259. DOI: 10.1016/J.Tetlet.2008.10.136  0.243
1990 Awad R, Hussain A, Crooks PA. Kinetics and mechanism of decomposition of N-chloroamino acids. II: Conformationally restricted models Journal of Pharmaceutical Sciences. 79: 1121-1122. PMID 2079660 DOI: 10.1002/Jps.2600791216  0.243
2017 Yadlapalli JS, Albayati ZA, Penthala NR, Hendrickson HP, Crooks PA. Stability studies of potent opioid analgesic, morphine-6-O-sulfate in various buffers and biological matrices by HPLC-DAD analysis. Biomedical Chromatography : Bmc. PMID 28205234 DOI: 10.1002/Bmc.3957  0.243
2005 Warren G, Grimes K, Crooks P, St. Clair W. Synergistic Radiosensitization of Lung Cancer Cells using Parthenolide and Low Dose Combinations of Proteasome or Cycloxygenase Inhibitors International Journal of Radiation Oncology*Biology*Physics. 63: S391-S392. DOI: 10.1016/J.Ijrobp.2005.07.669  0.243
2008 Papke RL, Dwoskin LP, Crooks PA, Zheng G, Zhang Z, McIntosh JM, Stokes C. Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras. Neuropharmacology. 54: 1189-200. PMID 18448138 DOI: 10.1016/J.Neuropharm.2008.03.010  0.243
2015 Zheng G, Crooks PA. Synthesis of Lobeline, Lobelane and their Analogues. A Review. Organic Preparations and Procedures International. 47: 317-337. PMID 26858465 DOI: 10.1080/00304948.2015.1066642  0.243
1984 Crooks PA, Tribé MJ, Pinney RJ. Inhibition of bacterial DNA cytosine‐5‐methyltransferase by S‐adenosyl‐l‐homocysteine and some related compounds Journal of Pharmacy and Pharmacology. 36: 85-89. PMID 6143811 DOI: 10.1111/J.2042-7158.1984.Tb02999.X  0.242
2008 Madhav JV, Kuarm BS, Someshwar P, Rajitha B, Reddy YT, Crooks PA. CuPy2Cl2: A Novel and Efficient Catalyst for Synthesis of Propargylamines Under the Conventional Method and Microwave Irradiation Synthetic Communications. 38: 3215-3223. DOI: 10.1080/00397910802109307  0.241
2008 Malkawi AH, Al-Ghananeem AM, de Leon J, Crooks PA. Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokers. Journal of Pharmaceutical and Biomedical Analysis. 49: 129-32. PMID 19036546 DOI: 10.1016/J.Jpba.2008.10.003  0.241
1989 BAWARSHI‐NASSAR RN, HUSSAIN A, CROOKS PA. Nasal absorption of 17α‐ethinyloestradiol in the rat Journal of Pharmacy and Pharmacology. 41: 214-215. PMID 2568456 DOI: 10.1111/J.2042-7158.1989.Tb06436.X  0.241
1982 Shaker MS, Crooks PA, Damani LA. High-performance liquid chromatographic analysis of the in vivo metabolites of [14C]pyridine Journal of Chromatography A. 237: 489-495. PMID 7096490 DOI: 10.1016/S0021-9673(00)97638-6  0.241
2018 Traver G, Sekhar KR, Renthala NR, Crooks PA, Ofori M, Freeman ML. Abstract 3189: Targeting NPM1 for controlling growth of Ewing sarcoma Cancer Research. 78: 3189-3189. DOI: 10.1158/1538-7445.Am2018-3189  0.241
2018 Yang Y, Nath D, Dutta A, Crooks PA, Mohi G. The NF-KB Inhibitor DMAPT in Combination with Ruxolitinib Displays Efficacy in Jak2V617F Knock-in Mouse Model of Myeloproliferative Neoplasms Blood. 132: 1783-1783. DOI: 10.1182/Blood-2018-99-120195  0.241
1974 CROOKS PA. ChemInform Abstract: A NEW SYNTHESIS OF 2-AMINOINDANES Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/Chin.197434240  0.241
2010 Kilbourn M, Sherman P, Quesada C, Vartak A, Crooks P, Dwoskin L. Effects of a lobelane analog on [11C]DTBZ binding to the VMAT2 Neuroimage. 52: S68. DOI: 10.1016/J.Neuroimage.2010.04.053  0.24
2014 Janardhan B, Rajitha B, Crooks PA. Poly(4-vinylpyridinium)hydrogen sulfate: An efficient heterogeneous catalyst for the one-pot synthesis of polyhydroquinolines via unsymmetrical Hantzsch reaction in aqueous medium Journal of Saudi Chemical Society. 18: 722-727. DOI: 10.1016/J.Jscs.2014.01.009  0.239
2005 Paudel KS, Nalluri BN, Hammell DC, Valiveti S, Kiptoo P, Hamad MO, Crooks PA, Stinchcomb AL. Transdermal delivery of naltrexone and its active metabolite 6-beta-naltrexol in human skin in vitro and guinea pigs in vivo. Journal of Pharmaceutical Sciences. 94: 1965-75. PMID 16052561 DOI: 10.1002/Jps.20398  0.239
2003 de Leon J, Diaz FJ, Rogers T, Browne D, Dinsmore L, Ghosheh OH, Dwoskin LP, Crooks PA. A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27: 165-71. PMID 12551740 DOI: 10.1016/S0278-5846(02)00348-2  0.239
2007 Zheng F, Zheng G, Deaciuc AG, Zhan CG, Dwoskin LP, Crooks PA. Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2. Bioorganic & Medicinal Chemistry. 15: 2975-92. PMID 17331733 DOI: 10.1016/J.Bmc.2007.02.013  0.239
2016 Penthala NR, Janganati V, Alpe TL, Apana SM, Berridge MS, Crooks PA, Borrelli MJ. N-[(11)CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat. Bioorganic & Medicinal Chemistry Letters. PMID 27866815 DOI: 10.1016/J.Bmcl.2016.11.015  0.239
2008 Holtman JR, Crooks PA, Johnson-Hardy J, Wala EP. Interaction between morphine and norketamine enantiomers in rodent models of nociception. Pharmacology, Biochemistry, and Behavior. 90: 769-77. PMID 18582492 DOI: 10.1016/J.Pbb.2008.05.019  0.238
2004 Hammell DC, Hamad M, Vaddi HK, Crooks PA, Stinchcomb AL. A duplex "Gemini" prodrug of naltrexone for transdermal delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 97: 283-90. PMID 15196755 DOI: 10.1016/J.Jconrel.2004.03.020  0.238
2017 Lee N, Zheng G, Mayfield SM, Denehy ED, Nickell JR, Cao Z, Crooks PA, Bardo M, Dwoksin L. Enantiomers of (±)GZ-888 potently and selectively inhibit vesicular monoamine transporter-2 function and methamphetamine-stimulated locomotor activity Drug and Alcohol Dependence. 171: e116. DOI: 10.1016/J.Drugalcdep.2016.08.324  0.237
1982 Benghiat E, Crooks PA. Preparation ofS-(3-Indolylmethyl) Derivatives of Mercaptoamino Acids Synthesis. 1982: 1033-1036. DOI: 10.1055/S-1982-30053  0.236
2020 Moore Ii JP, Dachavaram SS, Bommagani S, Penthala NR, Venkatraman P, Foster EJ, Crooks PA, A Hestekin J. Oxone-Mediated TEMPO-Oxidized Cellulose Nanomaterials form I and form II. Molecules (Basel, Switzerland). 25. PMID 32316421 DOI: 10.3390/Molecules25081847  0.236
2013 Yip-Schneider MT, Wu H, Hruban RH, Lowy AM, Crooks PA, Schmidt CM. Efficacy of dimethylaminoparthenolide and sulindac in combination with gemcitabine in a genetically engineered mouse model of pancreatic cancer. Pancreas. 42: 160-7. PMID 22699205 DOI: 10.1097/Mpa.0B013E318254F455  0.236
1988 WINKLE SA, CROOKS PA. Equilibrium binding of spermine and histamine to salmon sperm DNA and poly(dGdC) Journal of Pharmacy and Pharmacology. 40: 809-811. PMID 2907565 DOI: 10.1111/J.2042-7158.1988.Tb05179.X  0.236
2012 Kuarm BS, Janardan B, Crooks PA, Rajitha B. Xanthan Sulfuric Acid: An Efficient Bio-supported and Recyclable Solid Acid Catalyst for the Synthesis of 2-Aryl Thiadiazolo Benzimidazoles Chinese Journal of Chemistry. 30: 947-950. DOI: 10.1002/Cjoc.201100137  0.236
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