Gerald I. Shulman - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
Physiology Biology, Endocrinology Biology, Biochemistry

344 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pol CJ, Pollak NM, Jurczak MJ, Zacharia E, Karagiannides I, Kyriazis ID, Ntziachristos P, Scerbo DA, Brown BR, Aifantis I, Shulman GI, Goldberg IJ, Drosatos K. Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21. Biochimica Et Biophysica Acta. Molecular Basis of Disease. PMID 31029826 DOI: 10.1016/j.bbadis.2019.04.010  0.6
2019 Zhao L, Pascual F, Bacudio L, Suchanek AL, Young PA, Li LO, Martin SA, Camporez JP, Perry RJ, Shulman GI, Klett EL, Coleman RA. Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1-deficiency increases amino acid use and impairs muscle function. The Journal of Biological Chemistry. PMID 30975900 DOI: 10.1074/jbc.RA118.006790  0.84
2019 Abulizi A, Camporez JP, Jurczak MJ, Høyer KF, Zhang D, Cline GW, Samuel VT, Shulman GI, Vatner DF. Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802706R. PMID 30922125 DOI: 10.1096/fj.201802706R  0.68
2019 Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI. Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nature Medicine. PMID 30733621 DOI: 10.1038/s41591-018-0220-6  0.84
2019 Perry RJ, Rabin-Court A, Song JD, Cardone RL, Wang Y, Kibbey RG, Shulman GI. Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats. Nature Communications. 10: 548. PMID 30710078 DOI: 10.1038/s41467-019-08466-w  0.84
2019 Goedeke L, Perry RJ, Shulman GI. Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes. Annual Review of Pharmacology and Toxicology. 59: 65-87. PMID 30625285 DOI: 10.1146/annurev-pharmtox-010716-104727  0.84
2018 Abulizi A, Camporez JP, Zhang D, Samuel VT, Shulman GI, Vatner DF. Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-Hydroxysteroid dehydrogenase type 1 transgenic mice. Metabolism: Clinical and Experimental. PMID 30576689 DOI: 10.1016/j.metabol.2018.12.003  0.68
2018 Gassaway BM, Petersen MC, Surovtseva YV, Barber KW, Sheetz JB, Aerni HR, Merkel JS, Samuel VT, Shulman GI, Rinehart J. PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 30181290 DOI: 10.1073/pnas.1804379115  0.68
2018 Petersen MC, Shulman GI. Mechanisms of Insulin Action and Insulin Resistance. Physiological Reviews. 98: 2133-2223. PMID 30067154 DOI: 10.1152/physrev.00063.2017  0.56
2018 Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI. Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nature Medicine. PMID 30038219 DOI: 10.1038/s41591-018-0125-4  0.84
2018 Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ. Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Reports. 24: 47-55. PMID 29972790 DOI: 10.1016/j.celrep.2018.06.008  0.84
2018 Goedeke L, Bates J, Vatner DF, Perry RJ, Wang T, Ramirez R, Li L, Ellis MW, Zhang D, Wong KE, Beysen C, Cline GW, Ray AS, Shulman GI. Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents. Hepatology (Baltimore, Md.). PMID 29790582 DOI: 10.1002/hep.30097  0.84
2018 Perry RJ, Shulman GI. The Role of Leptin in Maintaining Plasma Glucose During Starvation. Postdoc Journal : a Journal of Postdoctoral Research and Postdoctoral Affairs. 6: 3-19. PMID 29682594 DOI: 10.14304/surya.jpr.v6n3.2  0.84
2018 Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C. Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis. Jci Insight. 3. PMID 29563332 DOI: 10.1172/jci.insight.97918  0.52
2018 Vatner DF, Goedeke L, Camporez JG, Lyu K, Nasiri AR, Zhang D, Bhanot S, Murray SF, Still CD, Gerhard GS, Shulman GI, Samuel VT. Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents. Diabetologia. PMID 29497783 DOI: 10.1007/s00125-018-4579-1  0.68
2018 Qiu Y, Perry RJ, Camporez JG, Zhang XM, Kahn M, Cline GW, Shulman GI, Vatner DF. Studies on the Mechanism of Methylenecyclopropylacetic acid and Methylenecyclopropylglycine-Induced Hypoglycemia. The Biochemical Journal. PMID 29483297 DOI: 10.1042/BCJ20180063  0.84
2018 Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfrán-Duque A, Diaz-Ruiz A, Araldi E, Baldán Á, Camporez JP, Suárez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernández-Hernando C. Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance. Cell Reports. 22: 2133-2145. PMID 29466739 DOI: 10.1016/j.celrep.2018.01.074  0.52
2018 Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI. Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature Communications. 9: 498. PMID 29386503 DOI: 10.1038/s41467-018-03023-3  0.84
2018 Lawan A, Min K, Zhang L, Canfran-Duque A, Jurczak MJ, Camporez JPG, Nie Y, Gavin TP, Shulman GI, Hernandez-Fernando C, Bennett AM. Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance. Diabetes. PMID 29317435 DOI: 10.2337/db17-0826  0.6
2017 Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, Zhang XM, Petersen KF, Shulman GI. Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation. Cell. PMID 29307489 DOI: 10.1016/j.cell.2017.12.001  0.84
2017 Camporez JP, Wang Y, Faarkrog K, Chukijrungroat N, Petersen KF, Shulman GI. Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice. Proceedings of the National Academy of Sciences of the United States of America. 114: E11285-E11292. PMID 29237750 DOI: 10.1073/pnas.1716990115  0.72
2017 Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes. PMID 29203511 DOI: 10.2337/db17-0524  0.84
2017 Perry RJ, Peng L, Cline GW, Wang Y, Rabin-Court A, Song JD, Zhang D, Zhang XM, Nozaki Y, Dufour S, Petersen KF, Shulman GI. Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes. Cell Metabolism. PMID 29129786 DOI: 10.1016/j.cmet.2017.10.004  0.84
2017 Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N. Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 114: E9172-E9180. PMID 29073114 DOI: 10.1073/pnas.1707797114  0.84
2017 Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Reports. 21: 1021-1035. PMID 29069585 DOI: 10.1016/j.celrep.2017.09.091  0.84
2017 Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI. Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature Communications. 8: 798. PMID 28986525 DOI: 10.1038/s41467-017-01143-w  0.84
2017 Pang XY, Wang S, Jurczak MJ, Shulman GI, Moise AR. Retinol saturase modulates lipid metabolism and the production of reactive oxygen species. Archives of Biochemistry and Biophysics. PMID 28927883 DOI: 10.1016/j.abb.2017.09.009  0.6
2017 Samuel VT, Shulman GI. Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. Cell Metabolism. PMID 28867301 DOI: 10.1016/j.cmet.2017.08.002  0.68
2017 Petersen MC, Vatner DF, Shulman GI. Regulation of hepatic glucose metabolism in health and disease. Nature Reviews. Endocrinology. PMID 28731034 DOI: 10.1038/nrendo.2017.80  0.56
2017 Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ. Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans. Cell Reports. 19: 1997-2004. PMID 28591572 DOI: 10.1016/j.celrep.2017.05.035  0.72
2017 Petersen MC, Shulman GI. Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance. Trends in Pharmacological Sciences. PMID 28551355 DOI: 10.1016/j.tips.2017.04.004  0.56
2017 Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT. Mitochondrial Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation. Diabetes. PMID 28476930 DOI: 10.2337/db16-1334  0.68
2017 Sharabi K, Lin H, Tavares CD, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, ... ... Shulman GI, et al. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 169: 148-160.e15. PMID 28340340 DOI: 10.1016/j.cell.2017.03.001  0.84
2017 Abulizi A, Perry RJ, Camporez JP, Jurczak MJ, Petersen KF, Aspichueta P, Shulman GI. A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28330852 DOI: 10.1096/fj.201700001R  0.84
2017 Corbit KC, Camporez JP, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. Jci Insight. 2: e91001. PMID 28194444 DOI: 10.1172/jci.insight.91001  0.84
2017 von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm M, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AF, Mingrone G, Bornstein SR, ... ... Shulman GI, et al. The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism. Hepatology (Baltimore, Md.). PMID 28133767 DOI: 10.1002/hep.29089  0.32
2017 Perry RJ, Peng L, Abulizi A, Kennedy L, Cline GW, Shulman GI. Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis. The Journal of Clinical Investigation. PMID 28112679 DOI: 10.1172/JCI88477  0.84
2017 Perry RJ, Peng L, Cline GW, Petersen KF, Shulman GI. A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo. Cell Metabolism. PMID 28111213 DOI: 10.1016/j.cmet.2016.12.017  0.84
2017 Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR. Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096339 DOI: 10.1073/pnas.1620506114  0.84
2016 Gilliland T, Dufour S, Shulman GI, Petersen KF, Emre SH. Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism. Pediatric Transplantation. PMID 27762491 DOI: 10.1111/petr.12819  0.72
2016 Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, ... Shulman GI, et al. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. The Journal of Clinical Investigation. PMID 27760050 DOI: 10.1172/JCI86013  0.68
2016 Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, ... Shulman GI, et al. MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nature Communications. 7: 12639. PMID 27577745 DOI: 10.1038/ncomms12639  0.8
2016 Kumamoto Y, Camporez JP, Jurczak MJ, Shanabrough M, Horvath T, Shulman GI, Iwasaki A. CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha. Immunity. PMID 27566941 DOI: 10.1016/j.immuni.2016.08.002  0.6
2016 Petersen KF, Befroy DE, Dufour S, Rothman DL, Shulman GI. Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy. Cell Metabolism. 24: 167-71. PMID 27411016 DOI: 10.1016/j.cmet.2016.06.005  0.72
2016 Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG. Imeglimin Lowers Glucose Primarily by Amplifying Glucose-Stimulated Insulin Secretion in High Fat Fed Rodents. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00009.2016. PMID 27406738 DOI: 10.1152/ajpendo.00009.2016  0.56
2016 Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI. Hypophosphatemia promotes lower rates of muscle ATP synthesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27338702 DOI: 10.1096/fj.201600473R  0.72
2016 Herrema H, Zhou Y, Zhang D, Lee J, Salazar Hernandez MA, Shulman GI, Ozcan U. XBP1s is an antilipogenic protein. The Journal of Biological Chemistry. PMID 27325692 DOI: 10.1074/jbc.M116.728949  0.56
2016 Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI. Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature. 534: 213-7. PMID 27279214 DOI: 10.1038/nature18309  0.8
2016 Madiraju AK, Alves T, Zhao X, Cline GW, Zhang D, Bhanot S, Samuel VT, Kibbey RG, Shulman GI. Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 27247419 DOI: 10.1073/pnas.1606022113  0.8
2016 Costa DK, Huckestein BR, Edmunds LR, Petersen MC, Nasiri A, Butrico GM, Abulizi A, Harmon DB, Lu C, Mantell BS, Hartman DJ, Camporez JG, O'Doherty RM, Cline GW, Shulman GI, et al. Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00042.2016. PMID 27166280 DOI: 10.1152/ajpendo.00042.2016  0.6
2016 Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI. Propionate increases hepatic pyruvate cycling, anaplerosis and alters mitochondrial metabolism. The Journal of Biological Chemistry. PMID 27002151 DOI: 10.1074/jbc.M116.720631  0.8
2016 Perry RJ, Petersen KF, Shulman GI. Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis. Diabetologia. 59: 933-7. PMID 26961503 DOI: 10.1007/s00125-016-3909-4  0.8
2016 Camporez JP, Petersen MC, Abudukadier A, Moreira GV, Jurczak MJ, Friedman G, Haqq CM, Petersen KF, Shulman GI. Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice. Proceedings of the National Academy of Sciences of the United States of America. 113: 2212-7. PMID 26858428 DOI: 10.1073/pnas.1525795113  0.8
2016 Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, ... ... Shulman GI, et al. 17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 26809497 DOI: 10.1093/gerona/glv309  0.6
2016 Samuel VT, Shulman GI. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. The Journal of Clinical Investigation. 126: 12-22. PMID 26727229 DOI: 10.1172/JCI77812  0.8
2015 Zaha VG, Qi D, Su KN, Palmeri M, Lee HY, Hu X, Wu X, Shulman GI, Rabinovitch PS, Russell R, Young LH. AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia. Journal of Molecular and Cellular Cardiology. PMID 26746142 DOI: 10.1016/j.yjmcc.2015.12.032  0.32
2015 Pesta DH, Perry RJ, Guebre-Egziabher F, Zhang D, Jurczak M, Fischer-Rosinsky A, Daniels MA, Willmes DM, Bhanot S, Bornstein SR, Knauf F, Samuel VT, Shulman GI, Birkenfeld AL. Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5). Aging. PMID 26647160  0.84
2015 Popov VB, Jornayvaz FR, Akgul EO, Kanda S, Jurczak MJ, Zhang D, Abudukadier A, Majumdar SK, Guigni B, Petersen KF, Manchem VP, Bhanot S, Shulman GI, Samuel VT. Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26644352 DOI: 10.1096/fj.15-271999  0.72
2015 Camell CD, Nguyen KY, Jurczak MJ, Shulman GI, Shadel GS, Dixit VD. Macrophage-specific de novo synthesis of ceramide is dispensable for inflammasome-driven inflammation and insulin-resistance in obesity. The Journal of Biological Chemistry. PMID 26438821 DOI: 10.1074/jbc.M115.680199  0.6
2015 Petersen KF, Morino K, Alves TC, Kibbey RG, Dufour S, Sono S, Yoo PS, Cline GW, Shulman GI. Effect of aging on muscle mitochondrial substrate utilization in humans. Proceedings of the National Academy of Sciences of the United States of America. 112: 11330-4. PMID 26305973 DOI: 10.1073/pnas.1514844112  0.8
2015 Perry RJ, Lee S, Ma L, Zhang D, Schlessinger J, Shulman GI. FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nature Communications. 6: 6980. PMID 25916467 DOI: 10.1038/ncomms7980  0.8
2015 Kliewer KL, Ke JY, Lee HY, Stout MB, Cole RM, Samuel VT, Shulman GI, Belury MA. Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice. The Journal of Nutritional Biochemistry. 26: 721-8. PMID 25913018 DOI: 10.1016/j.jnutbio.2015.01.010  0.8
2015 Perry RJ, Zhang D, Zhang XM, Boyer JL, Shulman GI. Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. Science (New York, N.Y.). 347: 1253-6. PMID 25721504 DOI: 10.1126/science.aaa0672  0.8
2015 Perry RJ, Camporez JP, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, ... ... Shulman GI, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 160: 745-58. PMID 25662011 DOI: 10.1016/j.cell.2015.01.012  0.8
2015 Befroy DE, Kibbey RG, Perry RJ, Petersen KF, Rothman DL, Shulman GI. Response to burgess. Nature Medicine. 21: 109-10. PMID 25654597 DOI: 10.1038/nm.3790  0.8
2015 Petersen MC, Rahimi Y, Camporez JP, Pesta D, Perry RJ, Jurczak MJ, Cline GW, Shulman GI. Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 112: E825. PMID 25617370 DOI: 10.1073/pnas.1423574112  0.8
2015 Laursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO. Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. Proceedings of the National Academy of Sciences of the United States of America. 112: 1607-12. PMID 25605929 DOI: 10.1073/pnas.1421419112  0.52
2015 Vatner DF, Majumdar SK, Kumashiro N, Petersen MC, Rahimi Y, Gattu AK, Bears M, Camporez JP, Cline GW, Jurczak MJ, Samuel VT, Shulman GI. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. Proceedings of the National Academy of Sciences of the United States of America. 112: 1143-8. PMID 25564660 DOI: 10.1073/pnas.1423952112  0.68
2015 Belman JP, Bian RR, Habtemichael EN, Li DT, Jurczak MJ, Alcázar-Román A, McNally LJ, Shulman GI, Bogan JS. Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment. The Journal of Biological Chemistry. 290: 4447-63. PMID 25561724 DOI: 10.1074/jbc.M114.603977  0.8
2015 Camporez JP, Kanda S, Petersen MC, Jornayvaz FR, Samuel VT, Bhanot S, Petersen KF, Jurczak MJ, Shulman GI. ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content. Journal of Lipid Research. 56: 526-36. PMID 25548259 DOI: 10.1194/jlr.M054080  0.8
2015 Banks AS, McAllister FE, Camporez JP, Zushin PJ, Jurczak MJ, Laznik-Bogoslavski D, Shulman GI, Gygi SP, Spiegelman BM. An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ. Nature. 517: 391-5. PMID 25409143 DOI: 10.1038/nature13887  0.6
2015 Lawan A, Zhang L, Gatzke F, Min K, Jurczak MJ, Al-Mutairi M, Richter P, Camporez JP, Couvillon A, Pesta D, Roth Flach RJ, Shulman GI, Bennett AM. Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis. Molecular and Cellular Biology. 35: 26-40. PMID 25312648 DOI: 10.1128/MCB.00503-14  0.6
2014 Shulman GI. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. The New England Journal of Medicine. 371: 2237-8. PMID 25470706 DOI: 10.1056/NEJMc1412427  0.8
2014 Gao Y, Wu F, Zhou J, Yan L, Jurczak MJ, Lee HY, Yang L, Mueller M, Zhou XB, Dandolo L, Szendroedi J, Roden M, Flannery C, Taylor H, Carmichael GG, ... Shulman GI, et al. The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells. Nucleic Acids Research. 42: 13799-811. PMID 25399420 DOI: 10.1093/nar/gku1160  0.8
2014 Rahimi Y, Camporez JP, Petersen MC, Pesta D, Perry RJ, Jurczak MJ, Cline GW, Shulman GI. Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 111: 16508-13. PMID 25368185 DOI: 10.1073/pnas.1419104111  0.8
2014 Feriod CN, Nguyen L, Jurczak MJ, Kruglov EA, Nathanson MH, Shulman GI, Bennett AM, Ehrlich BE. Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II. American Journal of Physiology. Endocrinology and Metabolism. 307: E1057-64. PMID 25315698 DOI: 10.1152/ajpendo.00236.2014  0.8
2014 Shulman GI. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. The New England Journal of Medicine. 371: 1131-41. PMID 25229917 DOI: 10.1056/NEJMra1011035  0.8
2014 Kibbey RG, Choi CS, Lee HY, Cabrera O, Pongratz RL, Zhao X, Birkenfeld AL, Li C, Berggren PO, Stanley C, Shulman GI. Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release. Diabetes. 63: 4218-29. PMID 25024374 DOI: 10.2337/db14-0783  0.8
2014 Szendroedi J, Yoshimura T, Phielix E, Koliaki C, Marcucci M, Zhang D, Jelenik T, Müller J, Herder C, Nowotny P, Shulman GI, Roden M. Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans. Proceedings of the National Academy of Sciences of the United States of America. 111: 9597-602. PMID 24979806 DOI: 10.1073/pnas.1409229111  0.8
2014 Perry RJ, Zhang XM, Zhang D, Kumashiro N, Camporez JP, Cline GW, Rothman DL, Shulman GI. Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nature Medicine. 20: 759-63. PMID 24929951 DOI: 10.1038/nm.3579  0.8
2014 Jelenik T, Séquaris G, Kaul K, Ouwens DM, Phielix E, Kotzka J, Knebel B, Weiß J, Reinbeck AL, Janke L, Nowotny P, Partke HJ, Zhang D, Shulman GI, Szendroedi J, et al. Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes. Diabetes. 63: 3856-67. PMID 24917575 DOI: 10.2337/db13-1794  0.56
2014 Perry RJ, Samuel VT, Petersen KF, Shulman GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 510: 84-91. PMID 24899308 DOI: 10.1038/nature13478  0.8
2014 Sajan MP, Ivey RA, Lee M, Mastorides S, Jurczak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV. PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. Molecular Endocrinology (Baltimore, Md.). 28: 1097-107. PMID 24877563 DOI: 10.1210/me.2014-1025  0.6
2014 Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 510: 547-51. PMID 24870244 DOI: 10.1038/nature13267  0.8
2014 Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, ... ... Shulman GI, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 510: 542-6. PMID 24847880 DOI: 10.1038/nature13270  0.8
2014 Lee HY, Gattu AK, Camporez JP, Kanda S, Guigni B, Kahn M, Zhang D, Galbo T, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Choi CS, Yan Z, Williams RS, Shulman GI, et al. Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia. 57: 1232-41. PMID 24718953 DOI: 10.1007/s00125-014-3212-1  0.8
2014 Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL, Friedman JE. Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes. 63: 2702-13. PMID 24705404 DOI: 10.2337/db14-0276  0.8
2014 Mehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR. Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis. The American Journal of Pathology. 184: 1562-76. PMID 24606881 DOI: 10.1016/j.ajpath.2014.01.009  0.8
2014 Giménez-Cassina A, Garcia-Haro L, Choi CS, Osundiji MA, Lane EA, Huang H, Yildirim MA, Szlyk B, Fisher JK, Polak K, Patton E, Wiwczar J, Godes M, Lee DH, Robertson K, ... ... Shulman GI, et al. Regulation of hepatic energy metabolism and gluconeogenesis by BAD Cell Metabolism. 19: 272-284. PMID 24506868 DOI: 10.1016/j.cmet.2013.12.001  0.8
2014 Stark R, Guebre-Egziabher F, Zhao X, Feriod C, Dong J, Alves TC, Ioja S, Pongratz RL, Bhanot S, Roden M, Cline GW, Shulman GI, Kibbey RG. A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis Journal of Biological Chemistry. 289: 7257-7263. PMID 24497630 DOI: 10.1074/jbc.C113.544759  0.8
2014 Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, ... ... Shulman GI, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 156: 304-16. PMID 24439384 DOI: 10.1016/j.cell.2013.12.021  0.8
2014 Wheeler SG, Hammond CL, Jornayvaz FR, Samuel VT, Shulman GI, Soroka CJ, Boyer JL, Hinkle PM, Ballatori N. Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity. American Journal of Physiology. Gastrointestinal and Liver Physiology. 306: G425-38. PMID 24381083 DOI: 10.1152/ajpgi.00368.2013  0.8
2014 Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer JK, Brosnan J, Rothman DL, Petersen KF, Shulman GI. Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy. Nature Medicine. 20: 98-102. PMID 24317120 DOI: 10.1038/nm.3415  0.8
2014 Neuschäfer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neuschäfer-Rube A, Pfeiffer AF, Shulman GI, et al. The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes. Diabetes. 63: 1048-57. PMID 24222346 DOI: 10.2337/db13-0749  0.8
2014 Birkenfeld AL, Shulman GI. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology (Baltimore, Md.). 59: 713-23. PMID 23929732 DOI: 10.1002/hep.26672  0.8
2013 Perry RJ, Shulman GI. Treating fatty liver and insulin resistance. Aging. 5: 791-2. PMID 24304662  0.8
2013 Perry RJ, Kim T, Zhang XM, Lee HY, Pesta D, Popov VB, Zhang D, Rahimi Y, Jurczak MJ, Cline GW, Spiegel DA, Shulman GI. Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. Cell Metabolism. 18: 740-8. PMID 24206666 DOI: 10.1016/j.cmet.2013.10.004  0.8
2013 Galbo T, Perry RJ, Nishimura E, Samuel VT, Quistorff B, Shulman GI. PP2A inhibition results in hepatic insulin resistance despite Akt2 activation. Aging. 5: 770-81. PMID 24150286  0.8
2013 Denton EV, Craig CJ, Pongratz RL, Appelbaum JS, Doerner AE, Narayanan A, Shulman GI, Cline GW, Schepartz A. A β-peptide agonist of the GLP-1 receptor, a class B GPCR. Organic Letters. 15: 5318-21. PMID 24087900 DOI: 10.1021/ol402568j  0.8
2013 Galbo T, Shulman GI. Lipid-induced hepatic insulin resistance. Aging. 5: 582-3. PMID 23929893  0.8
2013 Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI. Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: 12780-5. PMID 23840067 DOI: 10.1073/pnas.1311176110  0.8
2013 Camporez JP, Jornayvaz FR, Petersen MC, Pesta D, Guigni BA, Serr J, Zhang D, Kahn M, Samuel VT, Jurczak MJ, Shulman GI. Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. Endocrinology. 154: 3099-109. PMID 23766126 DOI: 10.1210/en.2013-1191  0.8
2013 Löffler MG, Birkenfeld AL, Philbrick KM, Belman JP, Habtemichael EN, Booth CJ, Castorena CM, Choi CS, Jornayvaz FR, Gassaway BM, Lee HY, Cartee GD, Philbrick W, Shulman GI, Samuel VT, et al. Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle. The Journal of Biological Chemistry. 288: 20135-50. PMID 23744065 DOI: 10.1074/jbc.M113.458075  0.8
2013 De Feyter HM, Mason GF, Shulman GI, Rothman DL, Petersen KF. Increased brain lactate concentrations without increased lactate oxidation during hypoglycemia in type 1 diabetic individuals. Diabetes. 62: 3075-80. PMID 23715622 DOI: 10.2337/db13-0313  0.8
2013 Vatner DF, Weismann D, Beddow SA, Kumashiro N, Erion DM, Liao XH, Grover GJ, Webb P, Phillips KJ, Weiss RE, Bogan JS, Baxter J, Shulman GI, Samuel VT. Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways. American Journal of Physiology. Endocrinology and Metabolism. 305: E89-100. PMID 23651850 DOI: 10.1152/ajpendo.00573.2012  0.8
2013 Erion DM, Kotas ME, McGlashon J, Yonemitsu S, Hsiao JJ, Nagai Y, Iwasaki T, Murray SF, Bhanot S, Cline GW, Samuel VT, Shulman GI, Gillum MP. cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis. The Journal of Biological Chemistry. 288: 16167-76. PMID 23595987 DOI: 10.1074/jbc.M113.460246  0.8
2013 Khan RS, Chokshi A, Drosatos K, Jiang H, Yu S, Harris CR, Schulze PC, Homma S, Blaner WS, Shulman GI, Huang LS, Goldberg IJ. Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy. Journal of Cardiovascular Pharmacology. 61: 345-54. PMID 23567901 DOI: 10.1097/FJC.0b013e318283d845  0.8
2013 Kotas ME, Jurczak MJ, Annicelli C, Gillum MP, Cline GW, Shulman GI, Medzhitov R. Role of caspase-1 in regulation of triglyceride metabolism Proceedings of the National Academy of Sciences of the United States of America. 110: 4810-4815. PMID 23487794 DOI: 10.1073/pnas.1301996110  0.8
2013 Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, ... ... Shulman GI, et al. Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance Diabetes. 62: 2183-2194. PMID 23423574 DOI: 10.2337/db12-1311  0.8
2013 Camporez JP, Jornayvaz FR, Lee HY, Kanda S, Guigni BA, Kahn M, Samuel VT, Carvalho CR, Petersen KF, Jurczak MJ, Shulman GI. Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology. 154: 1021-8. PMID 23364948 DOI: 10.1210/en.2012-1989  0.8
2013 Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, Guebre-Egziabher F, Jurczak MJ, Kahn M, Guigni BA, Serr J, Hankin J, Murphy RC, Cline GW, Bhanot S, ... ... Shulman GI, et al. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 110: 1869-74. PMID 23302688 DOI: 10.1073/pnas.1219456110  0.8
2013 Kursawe R, Caprio S, Giannini C, Narayan D, Lin A, D'Adamo E, Shaw M, Pierpont B, Cushman SW, Shulman GI. Decreased transcription of ChREBP-α/β isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia. Diabetes. 62: 837-44. PMID 23209190 DOI: 10.2337/db12-0889  0.8
2013 Kumashiro N, Yoshimura T, Cantley JL, Majumdar SK, Guebre-Egziabher F, Kursawe R, Vatner DF, Fat I, Kahn M, Erion DM, Zhang XM, Zhang D, Manchem VP, Bhanot S, Gerhard GS, ... ... Shulman GI, et al. Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats Hepatology. 57: 1763-1772. PMID 23175050 DOI: 10.1002/hep.26170  0.8
2013 Erion DM, Popov V, Hsiao JJ, Vatner D, Mitchell K, Yonemitsu S, Nagai Y, Kahn M, Gillum MP, Dong J, Murray SF, Manchem VP, Bhanot S, Cline GW, Shulman GI, et al. The role of the carbohydrate response element-binding protein in male fructose-fed rats Endocrinology. 154: 36-44. PMID 23161873 DOI: 10.1210/en.2012-1725  0.8
2012 Dominy JE, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, et al. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Molecular Cell. 48: 900-13. PMID 23142079 DOI: 10.1016/j.molcel.2012.09.030  0.8
2012 Befroy DE, Rothman DL, Petersen KF, Shulman GI. ³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism. Diabetes. 61: 2669-78. PMID 23093656 DOI: 10.2337/db12-0558  0.8
2012 Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel VT, Cravatt BF, Diano S, Shulman GI. Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. Proceedings of the National Academy of Sciences of the United States of America. 109: 14966-71. PMID 22912404 DOI: 10.1073/pnas.1212887109  0.8
2012 Flannery C, Dufour S, Rabøl R, Shulman GI, Petersen KF. Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. Diabetes. 61: 2711-7. PMID 22829450 DOI: 10.2337/db12-0206  0.8
2012 Li X, Shan J, Chang W, Kim I, Bao J, Lee HJ, Zhang X, Samuel VT, Shulman GI, Liu D, Zheng JJ, Wu D. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 109: 11402-7. PMID 22733757 DOI: 10.1073/pnas.1205015109  0.8
2012 Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM. Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proceedings of the National Academy of Sciences of the United States of America. 109: 9635-40. PMID 22645355 DOI: 10.1073/pnas.1207287109  0.8
2012 Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature Medicine. 18: 934-42. PMID 22561686 DOI: 10.1038/nm.2744  0.8
2012 Jornayvaz FR, Shulman GI. Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance. Cell Metabolism. 15: 574-84. PMID 22560210 DOI: 10.1016/j.cmet.2012.03.005  0.8
2012 Petersen KF, Dufour S, Morino K, Yoo PS, Cline GW, Shulman GI. Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes Proceedings of the National Academy of Sciences of the United States of America. 109: 8236-8240. PMID 22547801 DOI: 10.1073/pnas.1205675109  0.8
2012 Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell. 148: 852-71. PMID 22385956 DOI: 10.1016/j.cell.2012.02.017  0.8
2012 Morino K, Petersen KF, Sono S, Choi CS, Samuel VT, Lin A, Gallo A, Zhao H, Kashiwagi A, Goldberg IJ, Wang H, Eckel RH, Maegawa H, Shulman GI. Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes. Diabetes. 61: 877-87. PMID 22368174 DOI: 10.2337/db11-1391  0.8
2012 Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 482: 179-85. PMID 22297845 DOI: 10.1038/nature10809  0.8
2012 Liu W, Singh R, Choi CS, Lee HY, Keramati AR, Samuel VT, Lifton RP, Shulman GI, Mani A. Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. The Journal of Biological Chemistry. 287: 7213-23. PMID 22232553 DOI: 10.1074/jbc.M111.286724  0.8
2012 Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, ... ... Shulman GI, et al. A guide to analysis of mouse energy metabolism. Nature Methods. 9: 57-63. PMID 22205519 DOI: 10.1038/nmeth.1806  0.8
2012 Jornayvaz FR, Lee HY, Jurczak MJ, Alves TC, Guebre-Egziabher F, Guigni BA, Zhang D, Samuel VT, Silva JE, Shulman GI. Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance. Endocrinology. 153: 583-91. PMID 22147010 DOI: 10.1210/en.2011-1793  0.8
2012 Jurczak MJ, Lee AH, Jornayvaz FR, Lee HY, Birkenfeld AL, Guigni BA, Kahn M, Samuel VT, Glimcher LH, Shulman GI. Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. The Journal of Biological Chemistry. 287: 2558-67. PMID 22128176 DOI: 10.1074/jbc.M111.316760  0.8
2011 Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, ... ... Shulman GI, et al. SirT1 regulates adipose tissue inflammation. Diabetes. 60: 3235-45. PMID 22110092 DOI: 10.2337/db11-0616  0.8
2011 Banks AS, Kim-Muller JY, Mastracci TL, Kofler NM, Qiang L, Haeusler RA, Jurczak MJ, Laznik D, Heinrich G, Samuel VT, Shulman GI, Papaioannou VE, Accili D. Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metabolism. 14: 587-97. PMID 22055502 DOI: 10.1016/j.cmet.2011.09.012  0.8
2011 Kotas ME, Lee HY, Gillum MP, Annicelli C, Guigni BA, Shulman GI, Medzhitov R. Impact of CD1d deficiency on metabolism. Plos One. 6: e25478. PMID 21980475 DOI: 10.1371/journal.pone.0025478  0.8
2011 Shulman GI, Helfand SL. Indy knockdown in mice mimics elements of dietary restriction. Aging. 3: 701. PMID 21937764  0.8
2011 Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proceedings of the National Academy of Sciences of the United States of America. 108: 16381-5. PMID 21930939 DOI: 10.1073/pnas.1113359108  0.8
2011 Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, ... ... Shulman GI, et al. Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature. 477: 477-81. PMID 21892191 DOI: 10.1038/nature10383  0.8
2011 Jamison RA, Stark R, Dong J, Yonemitsu S, Zhang D, Shulman GI, Kibbey RG. Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats. American Journal of Physiology. Endocrinology and Metabolism. 301: E1174-83. PMID 21862723 DOI: 10.1152/ajpendo.00175.2011  0.8
2011 Birkenfeld AL, Lee HY, Majumdar S, Jurczak MJ, Camporez JP, Jornayvaz FR, Frederick DW, Guigni B, Kahn M, Zhang D, Weismann D, Arafat AM, Pfeiffer AF, Lieske S, Oyadomari S, ... ... Shulman GI, et al. Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism. The Journal of Biological Chemistry. 286: 36163-70. PMID 21832042 DOI: 10.1074/jbc.M111.228817  0.8
2011 Rabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proceedings of the National Academy of Sciences of the United States of America. 108: 13705-9. PMID 21808028 DOI: 10.1073/pnas.1110105108  0.8
2011 Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D. Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nature Medicine. 17: 961-7. PMID 21804540 DOI: 10.1038/nm.2378  0.8
2011 Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, ... ... Shulman GI, et al. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metabolism. 14: 184-95. PMID 21803289 DOI: 10.1016/j.cmet.2011.06.009  0.8
2011 Lee HY, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Kanda S, Popov V, Frederick DW, Zhang D, Guigni B, Bharadwaj KG, Choi CS, Goldberg IJ, Park JH, Petersen KF, Samuel VT, ... Shulman GI, et al. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology (Baltimore, Md.). 54: 1650-60. PMID 21793029 DOI: 10.1002/hep.24571  0.8
2011 Ahmadian M, Abbott MJ, Tang T, Hudak CS, Kim Y, Bruss M, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Wang Y, Duncan RE, Kang C, Sul HS. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metabolism. 13: 739-48. PMID 21641555 DOI: 10.1016/j.cmet.2011.05.002  0.8
2011 Stapleton CM, Mashek DG, Wang S, Nagle CA, Cline GW, Thuillier P, Leesnitzer LM, Li LO, Stimmel JB, Shulman GI, Coleman RA. Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1. Plos One. 6: e18932. PMID 21533082 DOI: 10.1371/journal.pone.0018932  0.8
2011 Befroy DE, Shulman GI. Magnetic resonance spectroscopy studies of human metabolism. Diabetes. 60: 1361-9. PMID 21525507 DOI: 10.2337/db09-0916  0.8
2011 Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science (New York, N.Y.). 331: 1621-4. PMID 21436455 DOI: 10.1126/science.1198363  0.8
2011 Jornayvaz FR, Birkenfeld AL, Jurczak MJ, Kanda S, Guigni BA, Jiang DC, Zhang D, Lee HY, Samuel VT, Shulman GI. Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proceedings of the National Academy of Sciences of the United States of America. 108: 5748-52. PMID 21436037 DOI: 10.1073/pnas.1103451108  0.8
2011 Horvath TL, Erion DM, Elsworth JD, Roth RH, Shulman GI, Andrews ZB. GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function. Neurobiology of Disease. 43: 152-62. PMID 21406233 DOI: 10.1016/j.nbd.2011.03.005  0.8
2011 Alves TC, Befroy DE, Kibbey RG, Kahn M, Codella R, Carvalho RA, Falk Petersen K, Shulman GI. Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance. Hepatology (Baltimore, Md.). 53: 1175-81. PMID 21400553 DOI: 10.1002/hep.24170  0.6
2011 Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG. SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. Diabetes. 60: 890-8. PMID 21357472 DOI: 10.2337/db10-1328  0.8
2011 Perfield JW, Lee Y, Shulman GI, Samuel VT, Jurczak MJ, Chang E, Xie C, Tsichlis PN, Obin MS, Greenberg AS. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes. 60: 1168-76. PMID 21346175 DOI: 10.2337/db10-0715  0.8
2011 Lin HV, Ren H, Samuel VT, Lee HY, Lu TY, Shulman GI, Accili D. Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues. Diabetes. 60: 700-9. PMID 21266328 DOI: 10.2337/db10-1056  0.8
2011 Ellis JM, Mentock SM, Depetrillo MA, Koves TR, Sen S, Watkins SM, Muoio DM, Cline GW, Taegtmeyer H, Shulman GI, Willis MS, Coleman RA. Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy. Molecular and Cellular Biology. 31: 1252-62. PMID 21245374 DOI: 10.1128/MCB.01085-10  0.8
2011 Srisai D, Gillum MP, Panaro BL, Zhang XM, Kotchabhakdi N, Shulman GI, Ellacott KL, Cone RD. Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse. Endocrinology. 152: 890-902. PMID 21239438 DOI: 10.1210/en.2010-0716  0.8
2011 Weismann D, Erion DM, Ignatova-Todorava I, Nagai Y, Stark R, Hsiao JJ, Flannery C, Birkenfeld AL, May T, Kahn M, Zhang D, Yu XX, Murray SF, Bhanot S, Monia BP, ... ... Shulman GI, et al. Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance Diabetologia. 54: 935-944. PMID 21190014 DOI: 10.1007/s00125-010-1984-5  0.8
2011 Gillum MP, Erion DM, Shulman GI. Sirtuin-1 regulation of mammalian metabolism. Trends in Molecular Medicine. 17: 8-13. PMID 20971038 DOI: 10.1016/j.molmed.2010.09.005  0.8
2011 Jornayvaz FR, Jurczak MJ, Samuel VT, Shulman GI. Reply to Monetti et al.: Hepatic steatosis and diacylglycerol-mediated hepatic insulin resistance in acyl-CoA:Diacylglycerol acyltransferase 2 (DGAT2) transgenic mice Proceedings of the National Academy of Sciences of the United States of America. 108. DOI: 10.1073/pnas.1109195108  0.8
2010 Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI. Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metabolism. 12: 668-74. PMID 21109199 DOI: 10.1016/j.cmet.2010.11.004  0.8
2010 Boumezbeur F, Petersen KF, Cline GW, Mason GF, Behar KL, Shulman GI, Rothman DL. The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13983-91. PMID 20962220 DOI: 10.1523/JNEUROSCI.2040-10.2010  0.8
2010 Bharadwaj KG, Hiyama Y, Hu Y, Huggins LA, Ramakrishnan R, Abumrad NA, Shulman GI, Blaner WS, Goldberg IJ. Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake. The Journal of Biological Chemistry. 285: 37976-86. PMID 20852327 DOI: 10.1074/jbc.M110.174458  0.8
2010 Jornayvaz FR, Jurczak MJ, Lee HY, Birkenfeld AL, Frederick DW, Zhang D, Zhang XM, Samuel VT, Shulman GI. A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain. American Journal of Physiology. Endocrinology and Metabolism. 299: E808-15. PMID 20807839 DOI: 10.1152/ajpendo.00361.2010  0.8
2010 Ayala JE, Samuel VT, Morton GJ, Obici S, Croniger CM, Shulman GI, Wasserman DH, McGuinness OP. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Disease Models & Mechanisms. 3: 525-34. PMID 20713647 DOI: 10.1242/dmm.006239  0.8
2010 Watkins D, Gallant C. Individual genomes on the horizon. The New England Journal of Medicine. 363: 195-6. PMID 20647218 DOI: 10.1056/NEJMc1005114  0.8
2010 Jornayvaz FR, Samuel VT, Shulman GI. The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. Annual Review of Nutrition. 30: 273-90. PMID 20645852 DOI: 10.1146/annurev.nutr.012809.104726  0.8
2010 Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet (London, England). 375: 2267-77. PMID 20609972 DOI: 10.1016/S0140-6736(10)60408-4  0.8
2010 Jornayvaz FR, Shulman GI. Regulation of mitochondrial biogenesis. Essays in Biochemistry. 47: 69-84. PMID 20533901 DOI: 10.1042/bse0470069  0.8
2010 Zhang D, Christianson J, Liu ZX, Tian L, Choi CS, Neschen S, Dong J, Wood PA, Shulman GI. Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency. Cell Metabolism. 11: 402-11. PMID 20444420 DOI: 10.1016/j.cmet.2010.03.012  0.56
2010 Erion DM, Shulman GI. Diacylglycerol-mediated insulin resistance. Nature Medicine. 16: 400-2. PMID 20376053 DOI: 10.1038/nm0410-400  0.8
2010 Olson DP, Pulinilkunnil T, Cline GW, Shulman GI, Lowell BB. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake Proceedings of the National Academy of Sciences of the United States of America. 107: 7598-7603. PMID 20368432 DOI: 10.1073/pnas.0913492107  0.8
2010 Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM, Dziura J, Lifton RP, Shulman GI. Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. The New England Journal of Medicine. 362: 1082-9. PMID 20335584 DOI: 10.1056/NEJMoa0907295  0.8
2010 Chutkow WA, Birkenfeld AL, Brown JD, Lee HY, Frederick DW, Yoshioka J, Patwari P, Kursawe R, Cushman SW, Plutzky J, Shulman GI, Samuel VT, Lee RT. Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes. 59: 1424-34. PMID 20299477 DOI: 10.2337/db09-1212  0.8
2010 Mitchell CS, Savage DB, Dufour S, Schoenmakers N, Murgatroyd P, Befroy D, Halsall D, Northcott S, Raymond-Barker P, Curran S, Henning E, Keogh J, Owen P, Lazarus J, Rothman DL, ... ... Shulman GI, et al. Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia. The Journal of Clinical Investigation. 120: 1345-54. PMID 20237409 DOI: 10.1172/JCI38793  0.8
2010 Wendel AA, Li LO, Li Y, Cline GW, Shulman GI, Coleman RA. Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity. Diabetes. 59: 1321-9. PMID 20200319 DOI: 10.2337/db09-1380  0.8
2010 Andrews ZB, Erion DM, Beiler R, Choi CS, Shulman GI, Horvath TL. Uncoupling protein-2 decreases the lipogenic actions of ghrelin. Endocrinology. 151: 2078-86. PMID 20189996 DOI: 10.1210/en.2009-0850  0.8
2010 Kursawe R, Narayan D, Cali AM, Shaw M, Pierpont B, Shulman GI, Caprio S. Downregulation of ADIPOQ and PPARγ2 gene expression in subcutaneous adipose tissue of obese adolescents with hepatic steatosis. Obesity (Silver Spring, Md.). 18: 1911-7. PMID 20168312 DOI: 10.1038/oby.2010.23  0.8
2010 Bajaj M, Baig R, Suraamornkul S, Hardies LJ, Coletta DK, Cline GW, Monroy A, Koul S, Sriwijitkamol A, Musi N, Shulman GI, DeFronzo RA. Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus. The Journal of Clinical Endocrinology and Metabolism. 95: 1916-23. PMID 20157197 DOI: 10.1210/jc.2009-0911  0.8
2010 Boumezbeur F, Mason GF, de Graaf RA, Behar KL, Cline GW, Shulman GI, Rothman DL, Petersen KF. Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 211-21. PMID 19794401 DOI: 10.1038/jcbfm.2009.197  0.8
2009 Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proceedings of the National Academy of Sciences of the United States of America. 106: 22510-5. PMID 20018698 DOI: 10.1073/pnas.0912533106  0.8
2009 Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, ... ... Shulman GI, et al. Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein Cell Metabolism. 10: 499-506. PMID 19945407 DOI: 10.1016/j.cmet.2009.10.007  0.8
2009 Roth RJ, Le AM, Zhang L, Kahn M, Samuel VT, Shulman GI, Bennett AM. MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. The Journal of Clinical Investigation. 119: 3817-29. PMID 19920356 DOI: 10.1172/JCI39054  0.8
2009 Leavens KF, Easton RM, Shulman GI, Previs SF, Birnbaum MJ. Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metabolism. 10: 405-18. PMID 19883618 DOI: 10.1016/j.cmet.2009.10.004  0.8
2009 Liu L, Shi X, Choi CS, Shulman GI, Klaus K, Nair KS, Schwartz GJ, Zhang Y, Goldberg IJ, Yu YH. Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1. Diabetes. 58: 2516-24. PMID 19675136 DOI: 10.2337/db08-1096  0.8
2009 Li LO, Ellis JM, Paich HA, Wang S, Gong N, Altshuller G, Thresher RJ, Koves TR, Watkins SM, Muoio DM, Cline GW, Shulman GI, Coleman RA. Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. The Journal of Biological Chemistry. 284: 27816-26. PMID 19648649 DOI: 10.1074/jbc.M109.022467  0.8
2009 Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, Kibbey RG. Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion Journal of Biological Chemistry. 284: 26578-26590. PMID 19635791 DOI: 10.1074/jbc.M109.011775  0.8
2009 Samuel VT, Beddow SA, Iwasaki T, Zhang XM, Chu X, Still CD, Gerhard GS, Shulman GI. Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes. Proceedings of the National Academy of Sciences of the United States of America. 106: 12121-6. PMID 19587243 DOI: 10.1073/pnas.0812547106  0.8
2009 Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, ... ... Shulman GI, et al. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proceedings of the National Academy of Sciences of the United States of America. 106: 11288-93. PMID 19549853 DOI: 10.1073/pnas.0812931106  0.8
2009 Dufour S, Lebon V, Shulman GI, Petersen KF. Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans. American Journal of Physiology. Endocrinology and Metabolism. 297: E231-5. PMID 19458062 DOI: 10.1152/ajpendo.00222.2009  0.8
2009 Befroy DE, Falk Petersen K, Rothman DL, Shulman GI. Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy. Methods in Enzymology. 457: 373-93. PMID 19426879 DOI: 10.1016/S0076-6879(09)05021-6  0.8
2009 Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW. Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1α and in HNF-1α-deficient islets Journal of Biological Chemistry. 284: 16808-16821. PMID 19376774 DOI: 10.1074/jbc.M807723200  0.8
2009 Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes. 58: 1499-508. PMID 19366863 DOI: 10.2337/db08-1571  0.8
2009 Nie Y, Erion DM, Yuan Z, Dietrich M, Shulman GI, Horvath TL, Gao Q. STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nature Cell Biology. 11: 492-500. PMID 19295512 DOI: 10.1038/ncb1857  0.8
2009 Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D, Jurczak MJ, Löffler MG, Cresswell J, Yu XX, Murray SF, Bhanot S, Monia BP, ... ... Shulman GI, et al. The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metabolism. 9: 252-64. PMID 19254570 DOI: 10.1016/j.cmet.2009.01.011  0.8
2009 Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nature Medicine. 15: 159-68. PMID 19136964 DOI: 10.1038/nm.1904  0.8
2009 Ahmadian M, Duncan RE, Varady KA, Frasson D, Hellerstein MK, Birkenfeld AL, Samuel VT, Shulman GI, Wang Y, Kang C, Sul HS. Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity. Diabetes. 58: 855-66. PMID 19136649 DOI: 10.2337/db08-1644  0.8
2009 Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, et al. Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues. Diabetes. 58: 116-24. PMID 18952837 DOI: 10.2337/db07-1839  0.8
2009 Rowe GC, Choi CS, Neff L, Horne WC, Shulman GI, Baron R. Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice. Endocrinology. 150: 135-43. PMID 18772235 DOI: 10.1210/en.2008-0678  0.8
2009 Samuel VT, Petersen KF, Shulman GI. Insulin Resistance The Liver: Biology and Pathobiology: Fifth Edition. 469-483. DOI: 10.1002/9780470747919.ch31  0.8
2008 Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, ... ... Shulman GI, et al. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 105: 19926-31. PMID 19066218 DOI: 10.1073/pnas.0810339105  0.8
2008 Gillum MP, Zhang D, Zhang XM, Erion DM, Jamison RA, Choi C, Dong J, Shanabrough M, Duenas HR, Frederick DW, Hsiao JJ, Horvath TL, Lo CM, Tso P, Cline GW, ... Shulman GI, et al. N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake. Cell. 135: 813-24. PMID 19041747 DOI: 10.1016/j.cell.2008.10.043  0.8
2008 Befroy DE, Petersen KF, Dufour S, Mason GF, Rothman DL, Shulman GI. Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals. Proceedings of the National Academy of Sciences of the United States of America. 105: 16701-6. PMID 18936488 DOI: 10.1073/pnas.0808889105  0.8
2008 Villena JA, Choi CS, Wang Y, Kim S, Hwang YJ, Kim YB, Cline G, Shulman GI, Sul HS. Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (pref-1): A new model of partial lipodystrophy Diabetes. 57: 3258-3266. PMID 18835937 DOI: 10.2337/db07-1739  0.8
2008 Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature. 454: 846-51. PMID 18668043 DOI: 10.1038/nature07181  0.8
2008 Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI. Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes. 57: 2644-51. PMID 18633112 DOI: 10.2337/db06-0454  0.8
2007 Wolfgang MJ, Cha SH, Sidhaye A, Chohnan S, Cline G, Shulman GI, Lane MD. Regulation of hypothalamic malonyl-CoA by central glucose and leptin. Proceedings of the National Academy of Sciences of the United States of America. 104: 19285-90. PMID 18032600 DOI: 10.1073/pnas.0709778104  0.8
2007 Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance Physiological Reviews. 87: 507-520. PMID 17429039 DOI: 10.1152/physrev.00024.2006  0.8
2007 Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW, Shulman GI. Mitochondrial GTP regulates glucose-stimulated insulin secretion. Cell Metabolism. 5: 253-64. PMID 17403370 DOI: 10.1016/j.cmet.2007.02.008  0.8
2007 Pongratz RL, Kibbey RG, Shulman GI, Cline GW. Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion. The Journal of Biological Chemistry. 282: 200-7. PMID 17102138 DOI: 10.1074/jbc.M602954200  0.8
2007 Mason GF, Petersen KF, de Graaf RA, Shulman GI, Rothman DL. Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose. Journal of Neurochemistry. 100: 73-86. PMID 17076763 DOI: 10.1111/j.1471-4159.2006.04200.x  0.8
2006 Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction Diabetes. 55. PMID 17130651 DOI: 10.2337/db06-S002  0.8
2006 Sørensen H, Brand CL, Neschen S, Holst JJ, Fosgerau K, Nishimura E, Shulman GI. Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice Diabetes. 55: 2843-2848. PMID 17003351 DOI: 10.2337/db06-0222  0.8
2006 Reznick RM, Shulman GI. The role of AMP-activated protein kinase in mitochondrial biogenesis. The Journal of Physiology. 574: 33-9. PMID 16709637 DOI: 10.1113/jphysiol.2006.109512  0.8
2006 Petersen KF, Shulman GI. New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy Obesity (Silver Spring, Md.). 14. PMID 16642961 DOI: 10.1038/oby.2006.280  0.8
2006 Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased brain monocarboxylic acid transport and utilization in type 1 diabetes. Diabetes. 55: 929-34. PMID 16567513 DOI: 10.2337/diabetes.55.04.06.db05-1325  0.8
2006 Petersen KF, Shulman GI. Etiology of insulin resistance American Journal of Medicine. 119. PMID 16563942 DOI: 10.1016/j.amjmed.2006.01.009  0.8
2006 Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, Scherer PE, Bernlohr DA. Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. American Journal of Physiology. Endocrinology and Metabolism. 290: E814-23. PMID 16303844 DOI: 10.1152/ajpendo.00465.2005  0.8
2006 Bilz S, Samuel V, Morino K, Savage D, Cheol SC, Shulman GI. Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters American Journal of Physiology - Endocrinology and Metabolism. 290. PMID 16291572 DOI: 10.1152/ajpendo.00355.2005  0.8
2006 Ritz E, Fujita T, Shulman GI. American Journal of Medicine: Introduction American Journal of Medicine. 119. DOI: 10.1016/j.amjmed.2006.01.007  0.8
2005 Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, DeFronzo RA. Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty acyl-CoAs and insulin action in type 2 diabetic patients Diabetes. 54: 3148-3153. PMID 16249438 DOI: 10.2337/diabetes.54.11.3148  0.8
2005 Petersen KF, Dufour S, Shulman GI. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents Plos Medicine. 2: 0879-0884. PMID 16089501 DOI: 10.1371/journal.pmed.0020233  0.8
2005 Savage DB, Petersen KF, Shulman GI. Mechanisms of insulin resistance in humans and possible links with inflammation Hypertension. 45: 828-833. PMID 15824195 DOI: 10.1161/01.HYP.0000163475.04421.e4  0.8
2005 Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE, Shulman GI. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes Diabetes. 54: 603-608. PMID 15734833 DOI: 10.2337/diabetes.54.3.603  0.8
2005 Kernan WN, Viscoli CM, Inzucchi SE, Brass LM, Bravata DM, Shulman GI, McVeety JC. Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke Archives of Internal Medicine. 165: 227-233. PMID 15668371 DOI: 10.1001/archinte.165.2.227  0.8
2005 Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science (New York, N.Y.). 307: 384-7. PMID 15662004 DOI: 10.1126/science.1104343  0.8
2005 Shulman GI, Rothman DL. MRS Studies of the role of the muscle glycogen synthesis pathway in the pathophysiology of type 2 diabetes Metabolomics by in Vivo Nmr. 45-57. DOI: 10.1002/0470011505.ch4  0.8
2004 Shulman GI. Unraveling the cellular mechanism of insulin resistance in humans: New insights from magnetic resonance spectroscopy Physiology. 19: 183-190. PMID 15304632  0.8
2004 Cline GW, Lepine RL, Papas KK, Kibbey RG, Shulman GI. 13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells. The Journal of Biological Chemistry. 279: 44370-5. PMID 15304488 DOI: 10.1074/jbc.M311842200  0.8
2004 Shen Q, Cline GW, Shulman GI, Leibowitz MD, Davies PJA. Effects of Rexinoids on Glucose Transport and Insulin-mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice Journal of Biological Chemistry. 279: 19721-19731. PMID 14998989 DOI: 10.1074/jbc.M311729200  0.8
2004 Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes New England Journal of Medicine. 350: 664-671. PMID 14960743 DOI: 10.1056/NEJMoa031314  0.8
2004 Erol E, Kumar LS, Cline GW, Shulman GI, Kelly DP, Binas B. Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 347-349. PMID 14656998  0.8
2003 Perseghin G, Petersen K, Shulman GI. Cellular mechanism of insulin resistance: Potential links with inflammation International Journal of Obesity. 27: S6-S11. PMID 14704736 DOI: 10.1038/sj.ijo.0802491  0.8
2003 Coven DL, Hu X, Cong L, Bergeron R, Shulman GI, Hardie DG, Young LH. Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise. American Journal of Physiology. Endocrinology and Metabolism. 285: E629-36. PMID 12759223 DOI: 10.1152/ajpendo.00171.2003  0.8
2003 Enoksson S, Caprio SK, Rife F, Shulman GI, Tamborlane WV, Sherwin RS. Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia. The Journal of Clinical Endocrinology and Metabolism. 88: 1503-11. PMID 12679430 DOI: 10.1210/jc.2002-021013  0.8
2003 Borg MA, Tamborlane WV, Shulman GI, Sherwin RS. Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation. Diabetes. 52: 663-6. PMID 12606506 DOI: 10.2337/diabetes.52.3.663  0.8
2002 Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proceedings of the National Academy of Sciences of the United States of America. 99: 15983-7. PMID 12444247 DOI: 10.1073/pnas.252625599  0.8
2002 McCrimmon RJ, Evans ML, Jacob RJ, Fan X, Zhu Y, Shulman GI, Sherwin RS. AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat. American Journal of Physiology. Endocrinology and Metabolism. 283: E1076-83. PMID 12376337 DOI: 10.1152/ajpendo.00195.2002  0.8
2002 Houmard JA, Tanner CJ, Yu C, Cunningham PG, Pories WJ, MacDonald KG, Shulman GI. Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects. Diabetes. 51: 2959-63. PMID 12351433  0.8
2002 Petersen KF, Shulman GI. Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus American Journal of Cardiology. 90. PMID 12231074  0.8
2002 Petersen KF, Shulman GI. Cellular mechanism of insulin resistance in skeletal muscle Journal of the Royal Society of Medicine, Supplement. 95: 8-13. PMID 12216329  0.8
2002 Kim YB, Shulman GI, Kahn BB. Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C Νζ but not on glycogen synthase kinase-3 Journal of Biological Chemistry. 277: 32915-32922. PMID 12095990 DOI: 10.1074/jbc.M204710200  0.8
2002 Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and β-cell dysfunction European Journal of Clinical Investigation. 32: 14-23. PMID 12028371 DOI: 10.1046/j.1365-2362.32.s3.3.x  0.8
2002 Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. The Journal of Clinical Investigation. 109: 1321-6. PMID 12021247 DOI: 10.1172/JCI14955  0.8
2001 Petersen KF, Laurent D, Yu C, Cline GW, Shulman GI. Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans Diabetes. 50: 1263-1268. PMID 11375325  0.8
2001 Petersen KF, Cline GW, Gerard DP, Magnusson I, Rothman DL, Shulman GI. Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans. Metabolism: Clinical and Experimental. 50: 598-601. PMID 11319724 DOI: 10.1053/meta.2001.22561  0.8
2001 Cline GW, Vidal-Puig AJ, Dufour S, Cadman KS, Lowell BB, Shulman GI. In Vivo Effects of Uncoupling Protein-3 Gene Disruption on Mitochondrial Energy Metabolism Journal of Biological Chemistry. 276: 20240-20244. PMID 11274222 DOI: 10.1074/jbc.M102540200  0.8
2001 Roden M, Petersen KF, Shulman GI. Nuclear magnetic resonance studies of hepatic glucose metabolism in humans Recent Progress in Hormone Research. 56: 219-237. PMID 11237214 DOI: 10.1210/rp.56.1.219  0.8
2000 Previs SF, Withers DJ, Ren JM, White MF, Shulman GI. Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo Journal of Biological Chemistry. 275: 38990-38994. PMID 10995761 DOI: 10.1074/jbc.M006490200  0.8
2000 Petersen KF, Krssak M, Inzucchi S, Cline GW, Dufour S, Shulman GI. Mechanism of troglitazone action in type 2 diabetes Diabetes. 49: 827-831. PMID 10905493  0.8
2000 McNulty PH, Cline GW, Whiting JM, Shulman GI. Regulation of myocardial [13C]glucose metabolism in conscious rats American Journal of Physiology - Heart and Circulatory Physiology. 279: H375-H381. PMID 10899078  0.8
2000 Ren JM, Barucci N, Marshall BA, Hansen P, Mueckler MM, Shulman GI. Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after exercise American Journal of Physiology - Endocrinology and Metabolism. 278. PMID 10751190  0.8
2000 Kim JK, Gavrilova O, Chen Y, Reitman ML, Shulman GI. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice Journal of Biological Chemistry. 275: 8456-8460. PMID 10722680 DOI: 10.1074/jbc.275.12.8456  0.8
2000 Price TB, Laurent D, Petersen KF, Rothman DL, Shulman GI. Glycogen loading alters muscle glycogen resynthesis after exercise. Journal of Applied Physiology (Bethesda, Md. : 1985). 88: 698-704. PMID 10658040  0.8
2000 Nagashima K, Cline GW, Mack GW, Shulman GI, Nadel ER. Intense exercise stimulates albumin synthesis in the upright posture Journal of Applied Physiology. 88: 41-46. PMID 10642360  0.8
1999 Jucker BM, Barucci N, Shulman GI. Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle. The American Journal of Physiology. 277: E505-12. PMID 10484363  0.8
1999 Russell RR, Bergeron R, Shulman GI, Young LH. Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. The American Journal of Physiology. 277: H643-9. PMID 10444490  0.8
1999 Shulman GI. Cellular mechanisms of insulin resistance in humans American Journal of Cardiology. 84. PMID 10418851  0.8
1999 Previs SF, Cline GW, Shulman GI. A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo American Journal of Physiology - Endocrinology and Metabolism. 277. PMID 10409139  0.8
1999 Roden M, Shulman GI. Applications of NMR spectroscopy to study muscle glycogen metabolism in man Annual Review of Medicine. 50: 277-290. PMID 10073278 DOI: 10.1146/annurev.med.50.1.277  0.8
1999 Misbin RI, Maggs DG, Shulman GI, Buchanan TA. The ethics of clinical research [4] (multiple letters) Annals of Internal Medicine. 130: 241. PMID 10049210  0.8
1999 Jucker BM, Cline GW, Barucci N, Shulman GI. Differential effects of safflower oil versus fish oil feeding on insulin-stimulated glycogen synthesis, glycolysis, and pyruvate dehydrogenase flux in skeletal muscle: a 13C nuclear magnetic resonance study. Diabetes. 48: 134-40. PMID 9892234 DOI: 10.2337/diabetes.48.1.134  0.8
1998 Inzucchi SE, Maggs DG, Spollett GR, Page SL, Rife FS, Walton V, Shulman GI. Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus New England Journal of Medicine. 338: 867-872. PMID 9516221 DOI: 10.1056/NEJM199803263381303  0.8
1998 Petersen KF, Laurent D, Rothman DL, Cline GW, Shulman GI. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. The Journal of Clinical Investigation. 101: 1203-9. PMID 9502760 DOI: 10.1172/JCI579  0.8
1998 Cline GW, Jucker BM, Trajanoski Z, Rennings AJ, Shulman GI. A novel 13C NMR method to assess intracellular glucose concentration in muscle, in vivo. The American Journal of Physiology. 274: E381-9. PMID 9486172  0.8
1998 Laurent D, Petersen KF, Russell RR, Cline GW, Shulman GI. Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans American Journal of Physiology - Endocrinology and Metabolism. 274. PMID 9458758  0.8
1997 Petersen KF, Jacob R, West AB, Sherwin RS, Shulman GI. Effects of insulin-like growth factor I on glucose metabolism in rats with liver cirrhosis. The American Journal of Physiology. 273: E1189-93. PMID 9435535  0.8
1997 Russell RR, Cline GW, Guthrie PH, Goodwin GW, Shulman GI, Taegtmeyer H. Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart. A three tracer study of glycolysis, glycogen metabolism, and glucose oxidation Journal of Clinical Investigation. 100: 2892-2899. PMID 9389756  0.8
1997 Jucker BM, Rennings AJ, Cline GW, Petersen KF, Shulman GI. In vivo NMR investigation of intramuscular glucose metabolism in conscious rats. The American Journal of Physiology. 273: E139-48. PMID 9252490  0.8
1997 Perseghin G, Ghosh S, Gerow K, Shulman GI. Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study Diabetes. 46: 1001-1009. PMID 9166672  0.8
1997 Cline GW, Magnusson I, Rothman DL, Petersen KF, Laurent D, Shulman GI. Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 99: 2219-24. PMID 9151794 DOI: 10.1172/JCI119395  0.8
1997 Jucker BM, Rennings AJ, Cline GW, Shulman GI. 13C and 31P NMR studies on the effects of increased plasma free fatty acids on intramuscular glucose metabolism in the awake rat. The Journal of Biological Chemistry. 272: 10464-73. PMID 9099689 DOI: 10.1074/jbc.272.16.10464  0.8
1997 Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. The Journal of Clinical Investigation. 99: 361-5. PMID 9006005 DOI: 10.1172/JCI119165  0.8
1997 Nagashima K, Cline GW, Mack GW, Shulman GI, Nadel ER. The mechanism underlying increased plasma albumin content associated with exercise-induced hypervolemia Faseb Journal. 11.  0.8
1996 Shulman GI. New views on the etiology of type II diabetes with Nuclear Magnetic Resonance Spectroscopy JournéEs Annuelles De DiabéTologie De L'HôTel-Dieu. 11-17. PMID 8965412  0.8
1996 Sidossis LS, Stuart CA, Shulman GI, Lopaschuk GD, Wolfe RR. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. The Journal of Clinical Investigation. 98: 2244-50. PMID 8941640 DOI: 10.1172/JCI119034  0.8
1996 Jacob RJ, Dziura J, Morgen JP, Shulman GI, Sherwin RS. Time course of the defective alpha-cell response to hypoglycemia in diabetic BB rats. Metabolism: Clinical and Experimental. 45: 1422-6. PMID 8931649 DOI: 10.1016/S0026-0495(96)90125-0  0.8
1996 Petersen KF, Price T, Cline GW, Rothman DL, Shulman GI. Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. The American Journal of Physiology. 270: E186-91. PMID 8772491  0.8
1996 Petersen KF, West AB, Reuben A, Rothman DL, Shulman GI. Noninvasive assessment of hepatic triglyceride content in humans with 13C nuclear magnetic resonance spectroscopy. Hepatology (Baltimore, Md.). 24: 114-7. PMID 8707248 DOI: 10.1002/hep.510240119  0.8
1996 McNulty PH, Sinusas AJ, Shi CQ, Dione D, Young LH, Cline GC, Shulman GI. Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia. The Journal of Clinical Investigation. 98: 62-9. PMID 8690805 DOI: 10.1172/JCI118778  0.8
1996 Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI. Mechanism of free fatty acid-induced insulin resistance in humans. The Journal of Clinical Investigation. 97: 2859-65. PMID 8675698 DOI: 10.1172/JCI118742  0.8
1996 Price TB, Perseghin G, Duleba A, Chen W, Chase J, Rothman DL, Shulman RG, Shulman GI. NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise. Proceedings of the National Academy of Sciences of the United States of America. 93: 5329-34. PMID 8643574 DOI: 10.1073/pnas.93.11.5329  0.8
1996 Taylor R, Magnusson I, Rothman DL, Cline GW, Caumo A, Cobelli C, Shulman GI. Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. The Journal of Clinical Investigation. 97: 126-32. PMID 8550823 DOI: 10.1172/JCI118379  0.8
1995 Rothman DL, Magnusson I, Cline G, Gerard D, Kahn CR, Shulman RG, Shulman GI. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America. 92: 983-7. PMID 7862678 DOI: 10.1073/pnas.92.4.983  0.8
1995 Hwang JH, Perseghin G, Rothman DL, Cline GW, Magnusson I, Petersen KF, Shulman GI. Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study. The Journal of Clinical Investigation. 95: 783-7. PMID 7860761 DOI: 10.1172/JCI117727  0.8
1995 Magnusson I, Rothman DL, Gerard DP, Katz LD, Shulman GI. Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration. Diabetes. 44: 185-9. PMID 7859939  0.8
1995 Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI. Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes. 44: 180-4. PMID 7859938  0.8
1995 Zawalich WS, Zawalich KC, Kelley GG, Shulman GI. Islet phosphoinositide hydrolysis and insulin secretory responses from prediabetic fa/fa ZDF rats Biochemical and Biophysical Research Communications. 209: 974-980. PMID 7733992 DOI: 10.1006/bbrc.1995.1593  0.8
1995 Cline GW, Shulman GI. Mass and positional isotopomer analysis of glucose metabolism in periportal and pericentral hepatocytes Journal of Biological Chemistry. 270: 28062-28067. PMID 7499292 DOI: 10.1074/jbc.270.47.28062  0.8
1995 Petersen KF, Blair JB, Shulman GI. Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver Metabolism. 44: 1380-1383. PMID 7476321 DOI: 10.1016/0026-0495(95)90133-7  0.8
1994 Bloch G, Chase JR, Meyer DB, Avison MJ, Shulman GI, Shulman RG. In vivo regulation of rat muscle glycogen resynthesis after intense exercise. The American Journal of Physiology. 266: E85-91. PMID 8304447  0.8
1994 Magnusson I, Rothman DL, Jucker B, Cline GW, Shulman RG, Shulman GI. Liver glycogen turnover in fed and fasted humans. The American Journal of Physiology. 266: E796-803. PMID 8203517  0.8
1994 Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GI. Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. The Journal of Clinical Investigation. 93: 1677-82. PMID 8163668 DOI: 10.1172/JCI117150  0.8
1994 Petersen KF, Cline GW, Blair JB, Shulman GI. Substrate cycling between pyruvate and oxaloacetate in awake normal and 3,3'-5-triiodo-L-thyronine-treated rats American Journal of Physiology - Endocrinology and Metabolism. 267. PMID 8074207  0.8
1994 Gruetter R, Magnusson I, Rothman DL, Avison MJ, Shulman RG, Shulman GI. Validation of 13C NMR measurements of liver glycogen in vivo. Magnetic Resonance in Medicine. 31: 583-8. PMID 8057810 DOI: 10.1002/mrm.1910310602  0.8
1994 Caprio S, Cline G, Boulware S, Permanente C, Shulman GI, Sherwin RS, Tamborlane WV. Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. The American Journal of Physiology. 266: E885-91. PMID 8023918  0.8
1994 Cline GW, Rothman DL, Magnusson I, Katz LD, Shulman GI. 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 94: 2369-76. PMID 7989593 DOI: 10.1172/JCI117602  0.8
1994 Price TB, Taylor R, Mason GF, Rothman DL, Shulman GI, Shulman RG. Turnover of human muscle glycogen with low-intensity exercise. Medicine and Science in Sports and Exercise. 26: 983-91. PMID 7968433  0.8
1994 Gruetter R, Novotny EJ, Boulware SD, Mason GF, Rothman DL, Shulman GI, Prichard JW, Shulman RG. Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose. Journal of Neurochemistry. 63: 1377-85. PMID 7931289  0.8
1994 Price TB, Rothman DL, Taylor R, Avison MJ, Shulman GI, Shulman RG. Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases. Journal of Applied Physiology (Bethesda, Md. : 1985). 76: 104-11. PMID 7909795  0.8
1994 Magnusson I, Rothman DL, Jucker B, Cline GW, Shulman RG, Shulman GI. Liver glycogen turnover in fed and fasted humans Am.J.Physiol.. 266.  0.8
1993 Rossi G, Lapaczewski P, Diamond MP, Jacob RJ, Shulman GI, Sherwin RS. Inhibitory effect of pregnancy on counterregulatory hormone responses to hypoglycemia in awake rat. Diabetes. 42: 1440-5. PMID 8375583  0.8
1993 Taylor R, Price TB, Katz LD, Shulman RG, Shulman GI. Direct measurement of change in muscle glycogen concentration after a mixed meal in normal subjects. The American Journal of Physiology. 265: E224-9. PMID 8368292  0.8
1993 Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Mason GF, Shulman GI, Tamborlane WV, Shulman RG. Non-invasive measurements of the cerebral steady-state glucose concentration and transport in humans by 13C nuclear magnetic resonance. Advances in Experimental Medicine and Biology. 331: 35-40. PMID 8333347  0.8
1993 Rossi G, Sherwin RS, Penzias AS, Lapaczewski P, Jacob RJ, Shulman GI, Diamond MP. Temporal changes in insulin resistance and secretion in 24-h-fasted conscious pregnant rats. The American Journal of Physiology. 265: E845-51. PMID 8279539  0.8
1993 Powell AM, Sherwin RS, Shulman GI. Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. Reversibility and stimulus specificity of the deficits. The Journal of Clinical Investigation. 92: 2667-74. PMID 8254023 DOI: 10.1172/JCI116883  0.8
1993 Cline GW, Greenawalt K, Shulman GI. Enhancement of the gluconeogenic flux of hepatic glycogen repletion by a phenacyl imidazolium compound in vivo. Acta Diabetologica. 30: 70-2. PMID 8219260 DOI: 10.1007/BF00578216  0.8
1993 Rossi G, Sherwin RS, Penzias AS, Lapaczewski P, Jacob RJ, Shulman GI, Diamond MP. Temporal changes in insulin resistance and secretion in 24-h-fasted conscious pregnant rats Am.J.Physiol.. 265.  0.8
1992 Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Mason GF, Shulman GI, Shulman RG, Tamborlane WV. Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 89: 1109-12. PMID 1736294  0.8
1992 Jacob RJ, Sherwin RS, Greenawalt K, Shulman GI. Simultaneous insulinlike growth factor I and insulin resistance in obese Zucker rats. Diabetes. 41: 691-7. PMID 1587396  0.8
1992 Rothman DL, Shulman RG, Shulman GI. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 89: 1069-75. PMID 1556176 DOI: 10.1172/JCI115686  0.8
1992 Shulman GI, Landau BR. Pathways of glycogen repletion. Physiological Reviews. 72: 1019-35. PMID 1438578  0.8
1992 Gruetter R, Rothman DL, Novotny EJ, Shulman GI, Prichard JW, Shulman RG. Detection and assignment of the glucose signal in 1H NMR difference spectra of the human brain. Magnetic Resonance in Medicine. 27: 183-8. PMID 1435204  0.8
1992 Taylor R, Price TB, Rothman DL, Shulman RG, Shulman GI. Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magnetic Resonance in Medicine. 27: 13-20. PMID 1435198  0.8
1992 Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. The Journal of Clinical Investigation. 90: 1323-7. PMID 1401068 DOI: 10.1172/JCI115997  0.8
1992 Ganesan S, Calle R, Zawalich K, Greenawalt K, Zawalich W, Shulman GI, Rasmussen H. Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion. The Journal of Cell Biology. 119: 313-24. PMID 1400576 DOI: 10.1083/jcb.119.2.313  0.8
1992 Sullivan WM, Kelley GG, O'Connor PG, Dickey PS, Kim JH, Robbins R, Shulman GI. Hypopituitarism associated with a hypothalamic CMV infection in a patient with AIDS The American Journal of Medicine. 92: 221-223. PMID 1311901 DOI: 10.1016/0002-9343(92)90119-V  0.8
1991 Shulman GI, DeFronzo RA, Rossetti L. Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion American Journal of Physiology - Endocrinology and Metabolism. 260. PMID 2035629  0.8
1991 Jacob RJ, Sherwin RS, Bowen L, Fryburg D, Fagin KD, Tamborlane WV, Shulman GI. Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats. The American Journal of Physiology. 260: E262-8. PMID 1996629  0.8
1991 Kahn BB, Shulman GI, DeFronzo RA, Cushman SW, Rossetti L. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. The Journal of Clinical Investigation. 87: 561-70. PMID 1991839 DOI: 10.1172/JCI115031  0.8
1991 Magnusson I, Shulman GI. Pathways of hepatic glycogen synthesis in humans Medicine and Science in Sports and Exercise. 23: 939-943. PMID 1956268  0.8
1991 Rothman DL, Magnusson I, Katz LD, Shulman RG, Shulman GI. Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science (New York, N.Y.). 254: 573-6. PMID 1948033  0.8
1991 Bowen L, Stein PP, Stevenson R, Shulman GI. The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats Metabolism. 40: 1025-1030. PMID 1943727 DOI: 10.1016/0026-0495(91)90124-F  0.8
1991 Rothman DL, Shulman RG, Shulman GI. N.m.r. studies of muscle glycogen synthesis in normal and non-insulin-dependent diabetic subjects. Biochemical Society Transactions. 19: 992-4. PMID 1794599  0.8
1991 Rothman DL, Howseman AM, Graham GD, Petroff OA, Lantos G, Fayad PB, Brass LM, Shulman GI, Shulman RG, Prichard JW. Localized proton NMR observation of [3-13C]lactate in stroke after [1-13C]glucose infusion. Magnetic Resonance in Medicine. 21: 302-7. PMID 1745129 DOI: 10.1002/mrm.1910210215  0.8
1991 Cline GW, Shulman GI. Quantitative analysis of the pathways of glycogen repletion in periportal and perivenous hepatocytes in vivo Journal of Biological Chemistry. 266: 4094-4098. PMID 1671859  0.8
1990 Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. The New England Journal of Medicine. 322: 223-8. PMID 2403659 DOI: 10.1056/NEJM199001253220403  0.8
1990 Shulman GI, Cline G, Schumann WC, Chandramouli V, Kumaran K, Landau BR. Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans. The American Journal of Physiology. 259: E335-41. PMID 2205106  0.8
1990 Zawalich WS, Zawalich KC, Shulman GI, Rossetti L. Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perifused rat islets Endocrinology. 126: 253-260. PMID 2152864  0.8
1989 Jue T, Rothman DL, Shulman GI, Tavitian BA, DeFronzo RA, Shulman RG. Direct observation of glycogen synthesis in human muscle with 13C NMR. Proceedings of the National Academy of Sciences of the United States of America. 86: 4489-91. PMID 2734301  0.8
1989 Shulman GI, Rossetti L. Influence of the route of glucose administration on hepatic glycogen repletion American Journal of Physiology - Endocrinology and Metabolism. 257. PMID 2688436  0.8
1989 Rossetti L, Rothman DL, DeFronzo RA, Shulman GI. Effect of dietary protein on in vivo insulin action and liver glycogen repletion. The American Journal of Physiology. 257: E212-9. PMID 2669515  0.8
1988 Miyoshi H, Shulman GI, Peters EJ, Wolfe MH, Elahi D, Wolfe RR. Hormonal control of substrate cycling in humans Journal of Clinical Investigation. 81: 1545-1555. PMID 3284915  0.8
1988 Shulman GI, Rothman DL, Chung Y, Rossetti L, Petit WA, Barrett EJ, Shulman RG. 13C NMR studies of glycogen turnover in the perfused rat liver. The Journal of Biological Chemistry. 263: 5027-9. PMID 3128534  0.8
1987 Shulman GI, Rossetti L, Rothman DL, Blair JB, Smith D. Quantitative analysis of glycogen repletion by nuclear magnetic resonance spectroscopy in the conscious rat. The Journal of Clinical Investigation. 80: 387-93. PMID 3611353 DOI: 10.1172/JCI113084  0.8
1987 Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissues sensitivity to insulin in diabetic rats Journal of Clinical Investigation. 79: 1510-1515. PMID 3571496  0.8
1987 Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats Journal of Clinical Investigation. 80: 1037-1044. PMID 3308956  0.8
1987 Rossetti L, Shulman GI, Zawalich WS. Physiological role of cholecystokinin in meal-induced insulin secretion in conscious rats. Studies with L 364718, a specific inhibitor of CCK-receptor binding Diabetes. 36: 1212-1215. PMID 3308589  0.8
1985 Shulman GI, Rothman DL, Smith D, Johnson CM, Blair JB, Shulman RG, DeFronzo RA. Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy. The Journal of Clinical Investigation. 76: 1229-36. PMID 4044833 DOI: 10.1172/JCI112078  0.8
1985 Shulman GI, Ladenson PW, Wolfe MH, Ridgway EC. Substrate cycling between gluconeogenesis and glycolysis in euthyroid, hypothyroid, and hyperthyroid man Journal of Clinical Investigation. 76: 757-764. PMID 4031071  0.8
1984 Shulman GI, Alger JR, Prichard JW, Shulman RG. Nuclear magnetic resonance spectroscopy in diagnostic and investigative medicine. The Journal of Clinical Investigation. 74: 1127-31. PMID 6384265 DOI: 10.1172/JCI111521  0.8
1984 Rothman DL, Arias-Mendoza F, Shulman GI, Shulman RG. A pulse sequence for simplifying hydrogen NMR spectra of biological tissues Journal of Magnetic Resonance (1969). 60: 430-436. DOI: 10.1016/0022-2364(84)90054-4  0.8
1981 Cherrington AD, Williams PE, Shulman GI, Lacy WW. Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog Diabetes. 30: 180-187. PMID 6110598  0.8
1980 Shulman GI, Williams PE, Liljenquist JE, Lacy WW, Keller U, Cherrington AD. Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog Metabolism. 29: 317-320. PMID 6103495 DOI: 10.1016/0026-0495(80)90004-9  0.8
1979 Cherrington AD, Liljenquist JE, Shulman GI. Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency American Journal of Physiology Endocrinology Metabolism and Gastrointestinal Physiology. 5.  0.8
1978 Shulman GI, Liljenquist JE, Williams PE, Lacy WW, Cherrington AD. Glucose disposal during insulinopenia in somatostatin-treated dogs. The roles of glucose and glucagon Journal of Clinical Investigation. 62: 487-491. PMID 670404  0.8
1976 Shulman GI, Dunbar JC. The effect of chronic sulfonylurea treatment on glucagon secretion in isolated pancreatic islets Clinical Research. 24.  0.8
Show low-probability matches.