| Year |
Citation |
Score |
| 2024 |
Calais Gaspar R, Sakuma I, Nasiri A, Hubbard BT, LaMoia TE, Leitner BP, Tep S, Xi Y, Greene EM, Ullman JC, Petersen KF, Shulman GI. Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease. American Journal of Physiology. Endocrinology and Metabolism. PMID 39171753 DOI: 10.1152/ajpendo.00175.2024 |
0.316 |
|
| 2024 |
Petersen MC, Smith GI, Palacios HH, Farabi SS, Yoshino M, Yoshino J, Cho K, Davila-Roman VG, Shankaran M, Barve RA, Yu J, Stern JH, Patterson BW, Hellerstein MK, Shulman GI, et al. Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity. Cell Metabolism. 36: 745-761.e5. PMID 38569471 DOI: 10.1016/j.cmet.2024.03.002 |
0.387 |
|
| 2023 |
Sakuma I, Gaspar RC, Luukkonen PK, Kahn M, Zhang D, Zhang X, Murray S, Golla JP, Vatner DF, Samuel VT, Petersen KF, Shulman GI. Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition. Proceedings of the National Academy of Sciences of the United States of America. 120: e2312666120. PMID 38127985 DOI: 10.1073/pnas.2312666120 |
0.625 |
|
| 2023 |
Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D. Author Correction: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nature Medicine. PMID 38041001 DOI: 10.1038/s41591-023-02695-9 |
0.661 |
|
| 2023 |
Park J, Hall C, Hubbard B, LaMoia T, Gaspar R, Nasiri A, Li F, Zhang H, Kim J, Haeusler RA, Accili D, Shulman GI, Yu H, Choi E. MAD2-dependent insulin receptor endocytosis regulates metabolic homeostasis. Diabetes. PMID 37725942 DOI: 10.2337/db23-0314 |
0.472 |
|
| 2023 |
Nakamoto A, Ohashi N, Sugawara L, Morino K, Ida S, Perry RJ, Sakuma I, Yanagimachi T, Fujita Y, Ugi S, Kume S, Shulman GI, Maegawa H. O-GlcNAc modification is essential for physiological adipose expansion induced by high-fat feeding. American Journal of Physiology. Endocrinology and Metabolism. PMID 37224467 DOI: 10.1152/ajpendo.00263.2022 |
0.549 |
|
| 2022 |
Gaspar RC, Lyu K, Hubbard BT, Leitner BP, Luukkonen PK, Hirabara SM, Sakuma I, Nasiri A, Zhang D, Kahn M, Cline GW, Pauli JR, Perry RJ, Petersen KF, Shulman GI. Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice. Diabetologia. PMID 36456864 DOI: 10.1007/s00125-022-05838-8 |
0.592 |
|
| 2022 |
Lee HY, Jang HR, Li H, Samuel VT, Dudek KD, Osipovich AB, Magnuson MA, Sklar J, Shulman GI. Deletion of gene causes early growth retardation and insulin resistance in mice. Proceedings of the National Academy of Sciences of the United States of America. 119: e2213628119. PMID 36442127 DOI: 10.1073/pnas.2213628119 |
0.692 |
|
| 2022 |
Huang Y, Zhou JH, Zhang H, Canfrán-Duque A, Singh AK, Perry RJ, Shulman G, Fernandez-Hernando C, Min W. Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance. The Journal of Clinical Investigation. PMID 35202005 DOI: 10.1172/JCI148852 |
0.562 |
|
| 2022 |
Goedeke L, Murt KN, Di Francesco A, Camporez JP, Nasiri AR, Wang Y, Zhang XM, Cline GW, de Cabo R, Shulman GI. Sex- and strain-specific effects of mitochondrial uncoupling on age-related metabolic diseases in high-fat diet-fed mice. Aging Cell. 21: e13539. PMID 35088525 DOI: 10.1111/acel.13539 |
0.329 |
|
| 2021 |
Bhat N, Narayanan A, Fathzadeh M, Kahn M, Zhang D, Goedeke L, Neogi A, Cardone RL, Kibbey RG, Fernandez-Hernando C, Ginsberg HN, Jain D, Shulman G, Mani A. Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. The Journal of Clinical Investigation. PMID 34855620 DOI: 10.1172/JCI153724 |
0.467 |
|
| 2021 |
Wang Q, Li D, Cao G, Shi Q, Zhu J, Zhang M, Cheng H, Wen Q, Xu H, Zhu L, Zhang H, Perry RJ, Spadaro O, Yang Y, He S, ... ... Shulman GI, et al. IL-27 signalling promotes adipocyte thermogenesis and energy expenditure. Nature. PMID 34819664 DOI: 10.1038/s41586-021-04127-5 |
0.473 |
|
| 2021 |
Jiang Z, Zhao M, Voilquin L, Jung Y, Aikio MA, Sahai T, Dou FY, Roche AM, Carcamo-Orive I, Knowles JW, Wabitsch M, Appel EA, Maikawa CL, Camporez JP, Shulman GI, et al. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Cell Metabolism. PMID 34348115 DOI: 10.1016/j.cmet.2021.07.010 |
0.517 |
|
| 2021 |
Schumann T, König J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, ... ... Shulman GI, et al. Publisher Correction: Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Communications Biology. 4: 890. PMID 34262128 DOI: 10.1038/s42003-021-02425-2 |
0.597 |
|
| 2021 |
Schumann T, König J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, ... ... Shulman GI, et al. Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Communications Biology. 4: 826. PMID 34211098 DOI: 10.1038/s42003-021-02279-8 |
0.654 |
|
| 2021 |
Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, López-Giráldez F, DeVries SG, Li H, Ruiz DM, Wang KY, Sayal BS, González Zapata S, Dann P, Brown SN, ... ... Shulman GI, et al. Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Nature Metabolism. PMID 33686286 DOI: 10.1038/s42255-021-00359-x |
0.445 |
|
| 2021 |
Lyu K, Zhang D, Song JD, Li X, Perry RJ, Samuel VT, Shulman GI. Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol - PKCε - insulin receptorT1160 phosphorylation. Jci Insight. PMID 33411692 DOI: 10.1172/jci.insight.139946 |
0.783 |
|
| 2021 |
He F, Huang Y, Song Z, Zhou HJ, Zhang H, Perry RJ, Shulman GI, Min W. Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance. The Journal of Experimental Medicine. 218. PMID 33315085 DOI: 10.1084/jem.20201416 |
0.665 |
|
| 2020 |
Abulizi A, Vatner DF, Ye Z, Wang Y, Camporez JP, Zhang D, Kahn M, Lyu K, Sirwi A, Cline GW, Hussain MM, Aspichueta P, Samuel VT, Shulman GI. Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice. Journal of Lipid Research. 61: 1565-1576. PMID 33455703 DOI: 10.1194/jlr.RA119000586 |
0.72 |
|
| 2020 |
Han MS, Perry RJ, Camporez JP, Scherer PE, Shulman GI, Gao G, Davis RJ. A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21. Genes & Development. PMID 33334822 DOI: 10.1101/gad.344556.120 |
0.512 |
|
| 2020 |
Li X, Zhang D, Vatner DF, Goedeke L, Hirabara SM, Zhang Y, Perry RJ, Shulman GI. Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 33293421 DOI: 10.1073/pnas.1922169117 |
0.667 |
|
| 2020 |
Ter Horst KW, Vatner DF, Zhang D, Cline GW, Ackermans MT, Nederveen AJ, Verheij J, Demirkiran A, van Wagensveld BA, Dallinga-Thie GM, Nieuwdorp M, Romijn JA, Shulman GI, Serlie MJ. Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease. Diabetes Care. PMID 33293347 DOI: 10.2337/dc20-1644 |
0.488 |
|
| 2020 |
Kahleova H, Petersen KF, Shulman GI, Alwarith J, Rembert E, Tura A, Hill M, Holubkov R, Barnard ND. Effect of a Low-Fat Vegan Diet on Body Weight, Insulin Sensitivity, Postprandial Metabolism, and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults: A Randomized Clinical Trial. Jama Network Open. 3: e2025454. PMID 33252690 DOI: 10.1001/jamanetworkopen.2020.25454 |
0.356 |
|
| 2020 |
Wang L, Sinnott-Armstrong N, Wagschal A, Wark AR, Camporez JP, Perry RJ, Ji F, Sohn Y, Oh J, Wu S, Chery J, Moud BN, Saadat A, Dankel SN, Mellgren G, ... ... Shulman GI, et al. A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. PMID 33058756 DOI: 10.1016/j.cell.2020.09.017 |
0.466 |
|
| 2020 |
Song JD, Alves TC, Befroy DE, Perry RJ, Mason GF, Zhang XM, Munk A, Zhang Y, Zhang D, Cline GW, Rothman DL, Petersen KF, Shulman GI. Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference. Cell Metabolism. PMID 33035493 DOI: 10.1016/j.cmet.2020.09.008 |
0.571 |
|
| 2020 |
Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, ... ... Shulman GI, et al. Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metabolism. PMID 32941798 DOI: 10.1016/J.Cmet.2020.08.016 |
0.53 |
|
| 2020 |
Abulizi A, Vatner DF, Ye Z, Wang Y, Camporez JP, Zhang D, Kahn M, Lyu K, Sirwi A, Cline GW, Hussain MM, Aspichueta P, Samuel VT, Shulman GI. Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP mice. Journal of Lipid Research. PMID 32907986 DOI: 10.1194/Jlr.Ra119000586 |
0.741 |
|
| 2020 |
Correa-de-Araujo R, Addison O, Miljkovic I, Goodpaster BH, Bergman BC, Clark RV, Elena JW, Esser KA, Ferrucci L, Harris-Love MO, Kritchevsky SB, Lorbergs A, Shepherd JA, Shulman GI, Rosen CJ. Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging. Frontiers in Physiology. 11: 963. PMID 32903666 DOI: 10.3389/Fphys.2020.00963 |
0.352 |
|
| 2020 |
LaMoia TE, Shulman GI. Cellular and Molecular Mechanisms of Metformin Action. Endocrine Reviews. PMID 32897388 DOI: 10.1210/Endrev/Bnaa023 |
0.399 |
|
| 2020 |
Lyu K, Zhang Y, Zhang D, Kahn M, Ter Horst KW, Rodrigues MRS, Gaspar RC, Hirabara SM, Luukkonen PK, Lee S, Bhanot S, Rinehart J, Blume N, Rasch MG, Serlie MJ, ... ... Shulman GI, et al. A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance. Cell Metabolism. PMID 32882164 DOI: 10.1016/J.Cmet.2020.08.001 |
0.711 |
|
| 2020 |
Perry RJ, Shulman GI. Sodium glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks. The Journal of Biological Chemistry. PMID 32796035 DOI: 10.1074/Jbc.Rev120.008387 |
0.588 |
|
| 2020 |
Yang Y, Li X, Luan HH, Zhang B, Zhang K, Nam JH, Li Z, Fu M, Munk A, Zhang D, Wang S, Liu Y, Albuquerque JP, Ong Q, Li R, ... ... Shulman GI, et al. OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance. Proceedings of the National Academy of Sciences of the United States of America. PMID 32601203 DOI: 10.1073/Pnas.1916121117 |
0.584 |
|
| 2020 |
Koh JH, Johnson ML, Dasari S, LeBrasseur NK, Vuckovic I, Henderson GC, Cooper SA, Manjunatha S, Ruegsegger GN, Shulman GI, Lanza IR, Nair KS. Erratum. TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle. Diabetes 2019;68:1552-1564. Diabetes. PMID 32532806 DOI: 10.2337/Db20-Er08A |
0.476 |
|
| 2020 |
Nozaki Y, Petersen MC, Zhang D, Vatner DF, Perry RJ, Abulizi A, Haedersdal S, Zhang XM, Butrico GM, Samuel VT, Mason GF, Cline GW, Petersen KF, Rothman DL, Shulman GI. Metabolic control analysis of hepatic glycogen synthesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 32188779 DOI: 10.1073/Pnas.1921694117 |
0.789 |
|
| 2020 |
Bilet L, Phielix E, van de Weijer T, Gemmink A, Bosma M, Moonen-Kornips E, Jorgensen JA, Schaart G, Zhang D, Meijer K, Hopman M, Hesselink MKC, Ouwens DM, Shulman GI, Schrauwen-Hinderling VB, et al. One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension. Diabetologia. PMID 32185462 DOI: 10.1007/S00125-020-05128-1 |
0.498 |
|
| 2020 |
Luukkonen PK, Dufour S, Lyu K, Zhang XM, Hakkarainen A, Lehtimäki TE, Cline GW, Petersen KF, Shulman GI, Yki-Järvinen H. Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 32179679 DOI: 10.1073/Pnas.1922344117 |
0.554 |
|
| 2020 |
Perry RJ, Lyu K, Rabin-Court A, Dong J, Li X, Yang Y, Qing H, Wang A, Yang X, Shulman GI. Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk. The Journal of Clinical Investigation. PMID 32149734 DOI: 10.1172/Jci134699 |
0.548 |
|
| 2020 |
Perry RJ, Zhang D, Guerra MT, Brill AL, Goedeke L, Nasiri AR, Rabin-Court A, Wang Y, Peng L, Dufour S, Zhang Y, Zhang XM, Butrico GM, Toussaint K, Nozaki Y, ... ... Shulman GI, et al. Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis. Nature. PMID 32132708 DOI: 10.1038/S41586-020-2074-6 |
0.697 |
|
| 2020 |
Tarabra E, Nouws J, Vash-Margita A, Nadzam GS, Goldberg-Gell R, Van Name M, Pierpont B, Knight J, Shulman GI, Caprio S. The omentum of obese girls harbors small adipocytes and browning transcripts. Jci Insight. PMID 32125283 DOI: 10.1172/Jci.Insight.135448 |
0.481 |
|
| 2020 |
Chande S, Caballero D, Ho BB, Fetene J, Serna J, Pesta D, Nasiri A, Jurczak M, Chavkin NW, Hernando N, Giachelli CM, Wagner CA, Zeiss C, Shulman GI, Bergwitz C. Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival. Scientific Reports. 10: 3069. PMID 32080237 DOI: 10.1038/S41598-020-59430-4 |
0.339 |
|
| 2020 |
Perry RJ, Shulman GI. Mechanistic Links between Obesity, Insulin, and Cancer. Trends in Cancer. 6: 75-78. PMID 32061306 DOI: 10.1016/J.Trecan.2019.12.003 |
0.614 |
|
| 2020 |
Sangwung P, Petersen KF, Shulman GI, Knowles JW. Mitochondrial dysfunction, insulin resistance and potential genetic implications. Endocrinology. PMID 32060542 DOI: 10.1210/Endocr/Bqaa017 |
0.491 |
|
| 2020 |
Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, Davis RJ. Regulation of adipose tissue inflammation by interleukin 6. Proceedings of the National Academy of Sciences of the United States of America. PMID 31980524 DOI: 10.1073/Pnas.1920004117 |
0.52 |
|
| 2020 |
Goedeke L, Rotllan N, Toussaint K, Nasiri A, Zhang X, Lee JE, Zhang X, Fernández-Hernando C, Shulman GI. 459-P: Liver-Targeted Mitochondrial Uncoupling by CRMP Improves Whole-Body Insulin Sensitivity and Attenuates Atherosclerosis in A LDLR-/- Mouse Model of Metabolic Syndrome Diabetes. 69. DOI: 10.2337/Db20-459-P |
0.527 |
|
| 2020 |
Lamoia TE, Lee JE, Guerra M, Goodman R, Shulman GI. 224-LB: Role of the Mitochondrial Calcium Uniporter in the Regulation of Hepatic Mitochondrial Metabolism and Gluconeogenesis Diabetes. 69. DOI: 10.2337/Db20-224-Lb |
0.301 |
|
| 2020 |
Galsgaard KD, Albrechtsen NJW, Holst JJ, Shulman GI, Petersen K, Nasiri A, Cline G, Zhang X, Lee JE, Hubbard BT. 220-LB: Glucagon Promotes Hepatic Autophagy by AMPK-Mediated mTORC1 Inhibition Diabetes. 69. DOI: 10.2337/Db20-220-Lb |
0.441 |
|
| 2020 |
Lyu K, Zhang D, Kahn M, Rodrigues MRS, Hirabara S, Luukkonen P, Lee S, Bhanot S, Rinehart J, Blume N, Rasch M, Serlie MJ, Bogan J, Cline G, Samuel V, ... Shulman GI, et al. 205-OR: Hepatic Protein Kinase C-e Is Necessary and Sufficient in Mediating Lipid-Induced Hepatic Insulin Resistance Diabetes. 69. DOI: 10.2337/Db20-205-Or |
0.713 |
|
| 2020 |
Morino K, Tsuji A, Ohashi N, Ida S, Perry RJ, Ugi S, Fujita Y, Shulman GI, Maegawa H. 1713-P: Adipocyte O-GlcNAc Transferase Regulate Adipogenesis through De Novo Lipogenesis in Mice Diabetes. 69. DOI: 10.2337/Db20-1713-P |
0.503 |
|
| 2020 |
Sakuma I, Yokoyama M, Yamagata K, Hashimoto N, Nakayama A, Shulman GI, Tanaka T. MON-635 FDXR Regulates Iron Metabolism and Glucose Metabolism in Liver Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.1557 |
0.393 |
|
| 2020 |
Petersen MC, Samuel VT, Petersen KF, Shulman GI. Non‐alcoholic Fatty Liver Disease and Insulin Resistance Liver. 455-471. DOI: 10.1002/9781119436812.Ch37 |
0.722 |
|
| 2019 |
Gassaway BM, Cardone RL, Padyana AK, Petersen MC, Judd ET, Hayes S, Tong S, Barber KW, Apostolidi M, Abulizi A, Sheetz JB, Kshitiz, Aerni HR, Gross S, Kung C, ... ... Shulman GI, et al. Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production. Cell Reports. 29: 3394-3404.e9. PMID 31825824 DOI: 10.1016/J.Celrep.2019.11.009 |
0.703 |
|
| 2019 |
Roden M, Shulman GI. The integrative biology of type 2 diabetes. Nature. 576: 51-60. PMID 31802013 DOI: 10.1038/S41586-019-1797-8 |
0.487 |
|
| 2019 |
Edmunds LR, Huckestein BR, Kahn M, Zhang D, Chu Y, Zhang Y, Wendell SG, Shulman GI, Jurczak MJ. Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis. Physiological Reports. 7: e14281. PMID 31724300 DOI: 10.14814/Phy2.14281 |
0.55 |
|
| 2019 |
Gómez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabón MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, ... ... Shulman GI, et al. Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nature Medicine. PMID 31700183 DOI: 10.1038/S41591-019-0610-4 |
0.565 |
|
| 2019 |
Samuel VT, Shulman GI. Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides. The New England Journal of Medicine. 381: 1866-1869. PMID 31693811 DOI: 10.1056/Nejmcibr1910023 |
0.733 |
|
| 2019 |
Goedeke L, Peng L, Montalvo-Romeral V, Butrico GM, Dufour S, Zhang XM, Perry RJ, Cline GW, Kievit P, Chng K, Petersen KF, Shulman GI. Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates. Science Translational Medicine. 11. PMID 31578240 DOI: 10.1126/Scitranslmed.Aay0284 |
0.624 |
|
| 2019 |
Petersen KF, Dufour S, Cline GW, Shulman GI. Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans. The Journal of Clinical Investigation. PMID 31545298 DOI: 10.1172/Jci129913 |
0.398 |
|
| 2019 |
Alkhouri N, Lawitz E, Noureddin M, DeFronzo R, Shulman GI. GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH). Expert Opinion On Investigational Drugs. 1-7. PMID 31519114 DOI: 10.1080/13543784.2020.1668374 |
0.383 |
|
| 2019 |
Petersen KF, Impellizeri A, Cline GW, Shulman GI. The effects of increased acetate turnover on glucose-induced insulin secretion in lean and obese humans. Journal of Clinical and Translational Science. 3: 18-20. PMID 31404159 DOI: 10.1017/cts.2018.342 |
0.393 |
|
| 2019 |
Samuel VT, Petersen MC, Gassaway BM, Vatner DF, Rinehart J, Shulman GI. Considering the links between NAFLD and insulin resistance: revisiting the role of protein kinase c ε. Hepatology (Baltimore, Md.). PMID 31220350 DOI: 10.1002/Hep.30829 |
0.734 |
|
| 2019 |
Perry RJ, Resch JM, Douglass AM, Madara JC, Rabin-Court A, Kucukdereli H, Wu C, Song JD, Lowell BB, Shulman GI. Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents. Proceedings of the National Academy of Sciences of the United States of America. PMID 31213533 DOI: 10.1073/Pnas.1901795116 |
0.502 |
|
| 2019 |
Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI. Anti-inflammatory effects of estrogen mediate the sexual dimorphic response to Lipid-induced insulin resistance. The Journal of Physiology. PMID 31206703 DOI: 10.1113/Jp277270 |
0.555 |
|
| 2019 |
Koh JH, Johnson ML, Dasari S, LeBrasseur NK, Vuckovic I, Henderson GC, Cooper SA, Manjunatha S, Ruegsegger GN, Shulman GI, Lanza IR, Nair KS. TFAM Enhances Fat Oxidation and Attenuates High Fat Diet Induced Insulin Resistance in Skeletal Muscle. Diabetes. PMID 31088855 DOI: 10.2337/Db19-0088 |
0.471 |
|
| 2019 |
Pol CJ, Pollak NM, Jurczak MJ, Zacharia E, Karagiannides I, Kyriazis ID, Ntziachristos P, Scerbo DA, Brown BR, Aifantis I, Shulman GI, Goldberg IJ, Drosatos K. Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21. Biochimica Et Biophysica Acta. Molecular Basis of Disease. PMID 31029826 DOI: 10.1016/J.Bbadis.2019.04.010 |
0.358 |
|
| 2019 |
Zhao L, Pascual F, Bacudio L, Suchanek AL, Young PA, Li LO, Martin SA, Camporez JP, Perry RJ, Shulman GI, Klett EL, Coleman RA. Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1-deficiency increases amino acid use and impairs muscle function. The Journal of Biological Chemistry. PMID 30975900 DOI: 10.1074/Jbc.Ra118.006790 |
0.54 |
|
| 2019 |
Nouws J, Fitch M, Mata M, Santoro N, Galuppo B, Kursawe R, Narayan D, Vash-Margita A, Pierpont B, Shulman GI, Hellerstein M, Caprio S. Altered Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues are Associated with the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls Diabetes. PMID 30936147 DOI: 10.2337/Db18-1162 |
0.401 |
|
| 2019 |
Abulizi A, Camporez JP, Jurczak MJ, Høyer KF, Zhang D, Cline GW, Samuel VT, Shulman GI, Vatner DF. Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802706R. PMID 30922125 DOI: 10.1096/Fj.201802706R |
0.762 |
|
| 2019 |
Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI. Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nature Medicine. PMID 30733621 DOI: 10.1038/S41591-018-0220-6 |
0.758 |
|
| 2019 |
Perry RJ, Rabin-Court A, Song JD, Cardone RL, Wang Y, Kibbey RG, Shulman GI. Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats. Nature Communications. 10: 548. PMID 30710078 DOI: 10.1038/S41467-019-08466-W |
0.628 |
|
| 2019 |
Goedeke L, Perry RJ, Shulman GI. Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes. Annual Review of Pharmacology and Toxicology. 59: 65-87. PMID 30625285 DOI: 10.1146/Annurev-Pharmtox-010716-104727 |
0.662 |
|
| 2019 |
PERRY RJ, RABIN-COURT A, DONG J, LYU K, LI X, SHULMAN GI. 99-OR: Leptin Mediates Postprandial Thermogenesis through a Hypothalamic-Adrenomedullary-BAT Axis Diabetes. 68: 99-OR. DOI: 10.2337/Db19-99-Or |
0.516 |
|
| 2019 |
PERRY RJ, RESCH J, DOUGLASS AM, MADARA J, SONG JD, WU C, LOWELL B, SHULMAN GI. 97-OR: Leptin's Hunger-Suppressing Effects Are Mediated by the Hypothalamic-Pituitary-Adrenocortical Axis Diabetes. 68: 97-OR. DOI: 10.2337/Db19-97-Or |
0.493 |
|
| 2019 |
LEE JE, GOEDEKE L, ZHANG Y, PERRY RJ, GOODMAN R, MOOTHA V, SHULMAN GI. 288-LB: Effects of the Hepatic Mitochondrial Calcium Uniporter on Hepatic Gluconeogenesis and Mitochondrial Metabolism in Awake Mice Diabetes. 68: 288-LB. DOI: 10.2337/Db19-288-Lb |
0.56 |
|
| 2019 |
VATNER DF, TER HORST KW, GOEDEKE L, ZHANG D, SAMUEL V, SERLIE MJ, SHULMAN GI. 283-LB: Dissociating Insulin Signaling and SREBP1c Action from the Lipogenic Drive Seen in Human and Murine Hepatic Insulin Resistance Diabetes. 68: 283-LB. DOI: 10.2337/Db19-283-Lb |
0.73 |
|
| 2019 |
LYU K, ZHANG Y, ZHANG D, KAHN M, NOZAKI Y, BHANOT S, BOGAN J, CLINE G, SAMUEL V, SHULMAN GI. 266-OR: Plasma Membrane sn-1,2 Diacylglycerol Mediates Lipid-Induced Hepatic Insulin Resistance Diabetes. 68: 266-OR. DOI: 10.2337/Db19-266-Or |
0.749 |
|
| 2019 |
PETERSEN K, DUFOUR S, CLINE G, SHULMAN GI. 225-OR: Key Role for Glucose-Alanine Cycling in the Regulation of Hepatic Mitochondrial Oxidation during Starvation in Humans Diabetes. 68: 225-OR. DOI: 10.2337/Db19-225-Or |
0.355 |
|
| 2019 |
GOEDEKE L, ROMERAL VM, BUTRICO GM, KAHN M, DUFOUR S, ZHANG X, CLINE G, PETERSEN K, CHNG K, SHULMAN GI. 19-OR: Controlled-Release Mitochondrial Protonophore (CRMP) Reverses Hypertriglyceridemia and Hepatic Steatosis in Dysmetabolic Nonhuman Primates Diabetes. 68: 19-OR. DOI: 10.2337/Db19-19-Or |
0.468 |
|
| 2019 |
ZHANG Y, ZHANG D, LYU K, SONG JD, LI X, PERRY RJ, SAMUEL V, SHULMAN GI. 1782-P: Mechanism of Lipid-Induced White Adipose Tissue Insulin Resistance Diabetes. 68: 1782-P. DOI: 10.2337/Db19-1782-P |
0.801 |
|
| 2019 |
LI X, ZHANG D, PERRY RJ, VATNER DF, GOEDEKE L, ZHANG Y, SHULMAN GI. 165-OR: The Mechanisms by Which Adiponectin Reverses Insulin Resistance in High-Fat Diet Fed Mice Diabetes. 68: 165-OR. DOI: 10.2337/Db19-165-Or |
0.699 |
|
| 2019 |
Rabin-Court A, Shulman GI, Perry RJ. Abstract 797: Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-797 |
0.587 |
|
| 2018 |
Abulizi A, Camporez JP, Zhang D, Samuel VT, Shulman GI, Vatner DF. Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-Hydroxysteroid dehydrogenase type 1 transgenic mice. Metabolism: Clinical and Experimental. PMID 30576689 DOI: 10.1016/J.Metabol.2018.12.003 |
0.735 |
|
| 2018 |
Gassaway BM, Petersen MC, Surovtseva YV, Barber KW, Sheetz JB, Aerni HR, Merkel JS, Samuel VT, Shulman GI, Rinehart J. PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 30181290 DOI: 10.1073/Pnas.1804379115 |
0.755 |
|
| 2018 |
Steinhauser ML, Olenchock BA, O'Keefe J, Lun M, Pierce KA, Lee H, Pantano L, Klibanski A, Shulman GI, Clish CB, Fazeli PK. The circulating metabolome of human starvation. Jci Insight. 3. PMID 30135314 DOI: 10.1172/Jci.Insight.121434 |
0.354 |
|
| 2018 |
Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, ... ... Shulman GI, et al. Lacteal junction zippering protects against diet-induced obesity. Science (New York, N.Y.). 361: 599-603. PMID 30093598 DOI: 10.1126/Science.Aap9331 |
0.342 |
|
| 2018 |
Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Reports. 24: 1085-1092.e6. PMID 30067966 DOI: 10.1016/J.Celrep.2018.06.112 |
0.477 |
|
| 2018 |
Petersen MC, Shulman GI. Mechanisms of Insulin Action and Insulin Resistance. Physiological Reviews. 98: 2133-2223. PMID 30067154 DOI: 10.1152/Physrev.00063.2017 |
0.544 |
|
| 2018 |
Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI. Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nature Medicine. PMID 30038219 DOI: 10.1038/S41591-018-0125-4 |
0.823 |
|
| 2018 |
Wang Y, Nasiri AR, Damsky WE, Perry CJ, Zhang XM, Rabin-Court A, Pollak MN, Shulman GI, Perry RJ. Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Reports. 24: 47-55. PMID 29972790 DOI: 10.1016/J.Celrep.2018.06.008 |
0.642 |
|
| 2018 |
Goedeke L, Bates J, Vatner DF, Perry RJ, Wang T, Ramirez R, Li L, Ellis MW, Zhang D, Wong KE, Beysen C, Cline GW, Ray AS, Shulman GI. Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents. Hepatology (Baltimore, Md.). PMID 29790582 DOI: 10.1002/Hep.30097 |
0.673 |
|
| 2018 |
Zhang N, Geng T, Wang Z, Zhang R, Cao T, Camporez JP, Cai SY, Liu Y, Dandolo L, Shulman GI, Carmichael GG, Taylor HS, Huang Y. Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia. Jci Insight. 3. PMID 29769440 DOI: 10.1172/Jci.Insight.120304 |
0.448 |
|
| 2018 |
Perry RJ, Shulman GI. The Role of Leptin in Maintaining Plasma Glucose During Starvation. Postdoc Journal : a Journal of Postdoctoral Research and Postdoctoral Affairs. 6: 3-19. PMID 29682594 DOI: 10.14304/Surya.Jpr.V6N3.2 |
0.634 |
|
| 2018 |
Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C. Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis. Jci Insight. 3. PMID 29563332 DOI: 10.1172/Jci.Insight.97918 |
0.504 |
|
| 2018 |
Vatner DF, Goedeke L, Camporez JG, Lyu K, Nasiri AR, Zhang D, Bhanot S, Murray SF, Still CD, Gerhard GS, Shulman GI, Samuel VT. Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents. Diabetologia. PMID 29497783 DOI: 10.1007/S00125-018-4579-1 |
0.746 |
|
| 2018 |
Qiu Y, Perry RJ, Camporez JG, Zhang XM, Kahn M, Cline GW, Shulman GI, Vatner DF.
Studies on the Mechanism of Methylenecyclopropylacetic acid and Methylenecyclopropylglycine-Induced Hypoglycemia. The Biochemical Journal. PMID 29483297 DOI: 10.1042/Bcj20180063 |
0.599 |
|
| 2018 |
Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfrán-Duque A, Diaz-Ruiz A, Araldi E, Baldán Á, Camporez JP, Suárez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernández-Hernando C. Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance. Cell Reports. 22: 2133-2145. PMID 29466739 DOI: 10.1016/J.Celrep.2018.01.074 |
0.33 |
|
| 2018 |
Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI. Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature Communications. 9: 498. PMID 29386503 DOI: 10.1038/S41467-018-03023-3 |
0.492 |
|
| 2018 |
Lawan A, Min K, Zhang L, Canfran-Duque A, Jurczak MJ, Camporez JPG, Nie Y, Gavin TP, Shulman GI, Hernandez-Fernando C, Bennett AM. Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance. Diabetes. PMID 29317435 DOI: 10.2337/Db17-0826 |
0.478 |
|
| 2018 |
PESTA D, ANADOL-SCHMITZ E, GANCHEVA S, MARKGRAF DF, ZAHARIA OP, KATSUYAMA H, KUPRIYANOVA Y, HWANG J, ZHANG D, SHULMAN GI, RODEN M. Unraveling the Athlete’s Paradox—Higher Insulin Sensitivity and Lower PKC? Activation Despite Higher Bioactive Lipids in Endurance-Trained Athletes Diabetes. 67: 267-LB. DOI: 10.2337/Db18-267-Lb |
0.429 |
|
| 2018 |
PERRY RJ, SONG JD, WANG Y, SHULMAN GI. Mechanism by Which Dapagliflozin Induces Euglycemic Ketoacidosis in Rats Diabetes. 67: 254-OR. DOI: 10.2337/Db18-254-Or |
0.528 |
|
| 2018 |
LYU K, ZHANG D, NOZAKI Y, ZHANG Y, BHANOT S, CLINE G, SAMUEL V, SHULMAN GI. Membrane sn-1,2 Diacylglycerol Mediates Lipid-Induced Hepatic Insulin Resistance In Vivo Diabetes. 67: 243-LB. DOI: 10.2337/Db18-243-Lb |
0.755 |
|
| 2018 |
SONG JD, PERRY RJ, MUNK A, ZHANG Y, ZHANG D, SHULMAN GI. Metabolic Inflexibility Revisited—Muscle Substrate Oxidation Is Mechanistically Dissociated from Muscle Insulin Resistance in Rats Diabetes. 67: 240-LB. DOI: 10.2337/Db18-240-Lb |
0.67 |
|
| 2018 |
VATNER DF, PETERSEN MC, LI X, ROGERS JC, CLINE G, SAMUEL V, SHULMAN GI. Evidence against Pathway-Selective Hepatic Insulin Resistance in Mice Diabetes. 67: 1766-P. DOI: 10.2337/Db18-1766-P |
0.751 |
|
| 2018 |
PERRY RJ, WANG Y, BRILL AL, PENG L, ZHANG D, DUFOUR S, ZHANG Y, ZHANG X, NOZAKI Y, CLINE G, EHRLICH BE, PETERSEN K, SHULMAN GI. Mechanisms by Which Glucagon Acutely Stimulates Hepatic Mitochondrial Oxidation and Gluconeogenesis Diabetes. 67: 146-OR. DOI: 10.2337/Db18-146-Or |
0.542 |
|
| 2018 |
GOEDEKE L, CAMPOREZ JP, NASIRI A, WANG Y, ZHANG X, SHULMAN GI. Effect of a Controlled-Release Mitochondrial Protonophore (CRMP) on Healthspan and Lifespan in Mice Diabetes. 67: 123-LB. DOI: 10.2337/Db18-123-Lb |
0.504 |
|
| 2017 |
Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, Zhang XM, Petersen KF, Shulman GI. Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation. Cell. PMID 29307489 DOI: 10.1016/J.Cell.2017.12.001 |
0.675 |
|
| 2017 |
Camporez JP, Wang Y, Faarkrog K, Chukijrungroat N, Petersen KF, Shulman GI. Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice. Proceedings of the National Academy of Sciences of the United States of America. 114: E11285-E11292. PMID 29237750 DOI: 10.1073/Pnas.1716990115 |
0.578 |
|
| 2017 |
Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes. PMID 29203511 DOI: 10.2337/Db17-0524 |
0.836 |
|
| 2017 |
Perry RJ, Peng L, Cline GW, Wang Y, Rabin-Court A, Song JD, Zhang D, Zhang XM, Nozaki Y, Dufour S, Petersen KF, Shulman GI. Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes. Cell Metabolism. PMID 29129786 DOI: 10.1016/J.Cmet.2017.10.004 |
0.692 |
|
| 2017 |
Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N. Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 114: E9172-E9180. PMID 29073114 DOI: 10.1073/Pnas.1707797114 |
0.692 |
|
| 2017 |
Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Reports. 21: 1021-1035. PMID 29069585 DOI: 10.1016/J.Celrep.2017.09.091 |
0.7 |
|
| 2017 |
Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI. Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA). Nature Communications. 8: 798. PMID 28986525 DOI: 10.1038/s41467-017-01143-w |
0.537 |
|
| 2017 |
Pang XY, Wang S, Jurczak MJ, Shulman GI, Moise AR. Retinol saturase modulates lipid metabolism and the production of reactive oxygen species. Archives of Biochemistry and Biophysics. PMID 28927883 DOI: 10.1016/J.Abb.2017.09.009 |
0.368 |
|
| 2017 |
Samuel VT, Shulman GI. Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. Cell Metabolism. PMID 28867301 DOI: 10.1016/J.Cmet.2017.08.002 |
0.752 |
|
| 2017 |
Petersen MC, Vatner DF, Shulman GI. Regulation of hepatic glucose metabolism in health and disease. Nature Reviews. Endocrinology. PMID 28731034 DOI: 10.1038/Nrendo.2017.80 |
0.557 |
|
| 2017 |
Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ. Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans. Cell Reports. 19: 1997-2004. PMID 28591572 DOI: 10.1016/J.Celrep.2017.05.035 |
0.742 |
|
| 2017 |
Petersen MC, Shulman GI. Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance. Trends in Pharmacological Sciences. PMID 28551355 DOI: 10.1016/J.Tips.2017.04.004 |
0.558 |
|
| 2017 |
Jelenik T, Kaul K, Séquaris G, Flögel U, Phielix E, Kotzka J, Knebel B, Fahlbusch P, Hörbelt T, Lehr S, Reinbeck AL, Müller-Wieland D, Esposito I, Shulman GI, Szendroedi J, et al. Mechanisms of Insulin Resistance in Primary and Secondary Non-Alcoholic Fatty Liver. Diabetes. PMID 28490610 DOI: 10.2337/Db16-1147 |
0.571 |
|
| 2017 |
Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT. Mitochondrial Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation. Diabetes. PMID 28476930 DOI: 10.2337/Db16-1334 |
0.743 |
|
| 2017 |
Sharabi K, Lin H, Tavares CD, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, ... ... Shulman GI, et al. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 169: 148-160.e15. PMID 28340340 DOI: 10.1016/J.Cell.2017.03.001 |
0.635 |
|
| 2017 |
Abulizi A, Perry RJ, Camporez JP, Jurczak MJ, Petersen KF, Aspichueta P, Shulman GI. A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28330852 DOI: 10.1096/Fj.201700001R |
0.669 |
|
| 2017 |
Corbit KC, Camporez JP, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. Jci Insight. 2: e91001. PMID 28194444 DOI: 10.1172/Jci.Insight.91001 |
0.707 |
|
| 2017 |
von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm M, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AF, Mingrone G, Bornstein SR, ... ... Shulman GI, et al. The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism. Hepatology (Baltimore, Md.). PMID 28133767 DOI: 10.1002/Hep.29089 |
0.414 |
|
| 2017 |
Perry RJ, Peng L, Abulizi A, Kennedy L, Cline GW, Shulman GI. Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis. The Journal of Clinical Investigation. PMID 28112679 DOI: 10.1172/Jci88477 |
0.674 |
|
| 2017 |
Perry RJ, Peng L, Cline GW, Petersen KF, Shulman GI. A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo. Cell Metabolism. PMID 28111213 DOI: 10.1016/J.Cmet.2016.12.017 |
0.593 |
|
| 2017 |
Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR. Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096339 DOI: 10.1073/Pnas.1620506114 |
0.522 |
|
| 2016 |
Gilliland T, Dufour S, Shulman GI, Petersen KF, Emre SH. Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism. Pediatric Transplantation. PMID 27762491 DOI: 10.1111/Petr.12819 |
0.346 |
|
| 2016 |
Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, ... Shulman GI, et al. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. The Journal of Clinical Investigation. PMID 27760050 DOI: 10.1172/Jci86013 |
0.854 |
|
| 2016 |
Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, ... Shulman GI, et al. MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nature Communications. 7: 12639. PMID 27577745 DOI: 10.1038/Ncomms12639 |
0.535 |
|
| 2016 |
Kumamoto Y, Camporez JP, Jurczak MJ, Shanabrough M, Horvath T, Shulman GI, Iwasaki A. CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha. Immunity. PMID 27566941 DOI: 10.1016/J.Immuni.2016.08.002 |
0.409 |
|
| 2016 |
Petersen KF, Befroy DE, Dufour S, Rothman DL, Shulman GI. Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy. Cell Metabolism. 24: 167-71. PMID 27411016 DOI: 10.1016/J.Cmet.2016.06.005 |
0.36 |
|
| 2016 |
Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG. Imeglimin Lowers Glucose Primarily by Amplifying Glucose-Stimulated Insulin Secretion in High Fat Fed Rodents. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00009.2016. PMID 27406738 DOI: 10.1152/Ajpendo.00009.2016 |
0.665 |
|
| 2016 |
Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI. Hypophosphatemia promotes lower rates of muscle ATP synthesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27338702 DOI: 10.1096/Fj.201600473R |
0.792 |
|
| 2016 |
Herrema H, Zhou Y, Zhang D, Lee J, Salazar Hernandez MA, Shulman GI, Ozcan U. XBP1s is an antilipogenic protein. The Journal of Biological Chemistry. PMID 27325692 DOI: 10.1074/Jbc.M116.728949 |
0.522 |
|
| 2016 |
Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI. Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome. Nature. 534: 213-7. PMID 27279214 DOI: 10.1038/Nature18309 |
0.615 |
|
| 2016 |
Madiraju AK, Alves T, Zhao X, Cline GW, Zhang D, Bhanot S, Samuel VT, Kibbey RG, Shulman GI. Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 27247419 DOI: 10.1073/Pnas.1606022113 |
0.817 |
|
| 2016 |
Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, ... Shulman GI, et al. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. PMID 27207531 DOI: 10.2337/db15-1128 |
0.481 |
|
| 2016 |
Costa DK, Huckestein BR, Edmunds LR, Petersen MC, Nasiri A, Butrico GM, Abulizi A, Harmon DB, Lu C, Mantell BS, Hartman DJ, Camporez JG, O'Doherty RM, Cline GW, Shulman GI, et al. Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00042.2016. PMID 27166280 DOI: 10.1152/Ajpendo.00042.2016 |
0.481 |
|
| 2016 |
Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI. Propionate increases hepatic pyruvate cycling, anaplerosis and alters mitochondrial metabolism. The Journal of Biological Chemistry. PMID 27002151 DOI: 10.1074/Jbc.M116.720631 |
0.611 |
|
| 2016 |
Perry RJ, Petersen KF, Shulman GI. Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis. Diabetologia. 59: 933-7. PMID 26961503 DOI: 10.1007/S00125-016-3909-4 |
0.649 |
|
| 2016 |
Camporez JP, Petersen MC, Abudukadier A, Moreira GV, Jurczak MJ, Friedman G, Haqq CM, Petersen KF, Shulman GI. Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice. Proceedings of the National Academy of Sciences of the United States of America. 113: 2212-7. PMID 26858428 DOI: 10.1073/Pnas.1525795113 |
0.465 |
|
| 2016 |
Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, ... ... Shulman GI, et al. 17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 26809497 DOI: 10.1093/Gerona/Glv309 |
0.377 |
|
| 2016 |
Samuel VT, Shulman GI. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. The Journal of Clinical Investigation. 126: 12-22. PMID 26727229 DOI: 10.1172/Jci77812 |
0.774 |
|
| 2016 |
Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S. A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents. Diabetes. 65: 610-8. PMID 26718495 DOI: 10.2337/Db15-1478 |
0.393 |
|
| 2015 |
DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC, Testa MA, Weiss R. Type 2 diabetes mellitus. Nature Reviews. Disease Primers. 1: 15019. PMID 27189025 DOI: 10.1038/nrdp.2015.19 |
0.394 |
|
| 2015 |
Zaha VG, Qi D, Su KN, Palmeri M, Lee HY, Hu X, Wu X, Shulman GI, Rabinovitch PS, Russell R, Young LH. AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia. Journal of Molecular and Cellular Cardiology. PMID 26746142 DOI: 10.1016/J.Yjmcc.2015.12.032 |
0.317 |
|
| 2015 |
Pesta DH, Perry RJ, Guebre-Egziabher F, Zhang D, Jurczak M, Fischer-Rosinsky A, Daniels MA, Willmes DM, Bhanot S, Bornstein SR, Knauf F, Samuel VT, Shulman GI, Birkenfeld AL. Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5). Aging. PMID 26647160 |
0.788 |
|
| 2015 |
Popov VB, Jornayvaz FR, Akgul EO, Kanda S, Jurczak MJ, Zhang D, Abudukadier A, Majumdar SK, Guigni B, Petersen KF, Manchem VP, Bhanot S, Shulman GI, Samuel VT. Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26644352 DOI: 10.1096/Fj.15-271999 |
0.814 |
|
| 2015 |
Camell CD, Nguyen KY, Jurczak MJ, Shulman GI, Shadel GS, Dixit VD. Macrophage-specific de novo synthesis of ceramide is dispensable for inflammasome-driven inflammation and insulin-resistance in obesity. The Journal of Biological Chemistry. PMID 26438821 DOI: 10.1074/Jbc.M115.680199 |
0.431 |
|
| 2015 |
Johnson ML, Distelmaier K, Lanza IR, Irving BA, Robinson MM, Konopka AR, Shulman GI, Nair KS. Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults. Diabetes. PMID 26324180 DOI: 10.2337/Db15-0675 |
0.503 |
|
| 2015 |
Petersen KF, Morino K, Alves TC, Kibbey RG, Dufour S, Sono S, Yoo PS, Cline GW, Shulman GI. Effect of aging on muscle mitochondrial substrate utilization in humans. Proceedings of the National Academy of Sciences of the United States of America. 112: 11330-4. PMID 26305973 DOI: 10.1073/Pnas.1514844112 |
0.464 |
|
| 2015 |
Perry RJ, Lee S, Ma L, Zhang D, Schlessinger J, Shulman GI. FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nature Communications. 6: 6980. PMID 25916467 DOI: 10.1038/Ncomms7980 |
0.631 |
|
| 2015 |
Kliewer KL, Ke JY, Lee HY, Stout MB, Cole RM, Samuel VT, Shulman GI, Belury MA. Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice. The Journal of Nutritional Biochemistry. 26: 721-8. PMID 25913018 DOI: 10.1016/J.Jnutbio.2015.01.010 |
0.639 |
|
| 2015 |
Perry RJ, Zhang D, Zhang XM, Boyer JL, Shulman GI. Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. Science (New York, N.Y.). 347: 1253-6. PMID 25721504 DOI: 10.1126/Science.Aaa0672 |
0.632 |
|
| 2015 |
Perry RJ, Camporez JP, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, ... ... Shulman GI, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 160: 745-58. PMID 25662011 DOI: 10.1016/J.Cell.2015.01.012 |
0.72 |
|
| 2015 |
Befroy DE, Kibbey RG, Perry RJ, Petersen KF, Rothman DL, Shulman GI. Response to burgess. Nature Medicine. 21: 109-10. PMID 25654597 DOI: 10.1038/Nm.3790 |
0.528 |
|
| 2015 |
Petersen MC, Rahimi Y, Camporez JP, Pesta D, Perry RJ, Jurczak MJ, Cline GW, Shulman GI. Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 112: E825. PMID 25617370 DOI: 10.1073/Pnas.1423574112 |
0.646 |
|
| 2015 |
Vatner DF, Majumdar SK, Kumashiro N, Petersen MC, Rahimi Y, Gattu AK, Bears M, Camporez JP, Cline GW, Jurczak MJ, Samuel VT, Shulman GI. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. Proceedings of the National Academy of Sciences of the United States of America. 112: 1143-8. PMID 25564660 DOI: 10.1073/Pnas.1423952112 |
0.762 |
|
| 2015 |
Belman JP, Bian RR, Habtemichael EN, Li DT, Jurczak MJ, Alcázar-Román A, McNally LJ, Shulman GI, Bogan JS. Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment. The Journal of Biological Chemistry. 290: 4447-63. PMID 25561724 DOI: 10.1074/Jbc.M114.603977 |
0.527 |
|
| 2015 |
Camporez JP, Kanda S, Petersen MC, Jornayvaz FR, Samuel VT, Bhanot S, Petersen KF, Jurczak MJ, Shulman GI. ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content. Journal of Lipid Research. 56: 526-36. PMID 25548259 DOI: 10.1194/Jlr.M054080 |
0.751 |
|
| 2015 |
Banks AS, McAllister FE, Camporez JP, Zushin PJ, Jurczak MJ, Laznik-Bogoslavski D, Shulman GI, Gygi SP, Spiegelman BM. An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ. Nature. 517: 391-5. PMID 25409143 DOI: 10.1038/Nature13887 |
0.453 |
|
| 2015 |
Lawan A, Zhang L, Gatzke F, Min K, Jurczak MJ, Al-Mutairi M, Richter P, Camporez JP, Couvillon A, Pesta D, Roth Flach RJ, Shulman GI, Bennett AM. Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis. Molecular and Cellular Biology. 35: 26-40. PMID 25312648 DOI: 10.1128/Mcb.00503-14 |
0.549 |
|
| 2015 |
Vatner DF, Majumdar SK, Kumashiro N, Petersen MC, Rahimi Y, Gattu AK, Bears M, Camporez JPG, Cline GW, Jurczak MJ, Samuel VT, Shulman GI. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids Proceedings of the National Academy of Sciences of the United States of America. 112: 1143-1148. DOI: 10.1073/pnas.1423952112 |
0.693 |
|
| 2014 |
Shulman GI. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. The New England Journal of Medicine. 371: 2237-8. PMID 25470706 DOI: 10.1056/NEJMc1412427 |
0.387 |
|
| 2014 |
Gao Y, Wu F, Zhou J, Yan L, Jurczak MJ, Lee HY, Yang L, Mueller M, Zhou XB, Dandolo L, Szendroedi J, Roden M, Flannery C, Taylor H, Carmichael GG, ... Shulman GI, et al. The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells. Nucleic Acids Research. 42: 13799-811. PMID 25399420 DOI: 10.1093/Nar/Gku1160 |
0.414 |
|
| 2014 |
Rahimi Y, Camporez JP, Petersen MC, Pesta D, Perry RJ, Jurczak MJ, Cline GW, Shulman GI. Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 111: 16508-13. PMID 25368185 DOI: 10.1073/Pnas.1419104111 |
0.674 |
|
| 2014 |
Feriod CN, Nguyen L, Jurczak MJ, Kruglov EA, Nathanson MH, Shulman GI, Bennett AM, Ehrlich BE. Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II. American Journal of Physiology. Endocrinology and Metabolism. 307: E1057-64. PMID 25315698 DOI: 10.1152/Ajpendo.00236.2014 |
0.384 |
|
| 2014 |
Tao H, Zhang Y, Zeng X, Shulman GI, Jin S. Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. Nature Medicine. 20: 1263-9. PMID 25282357 DOI: 10.1038/Nm.3699 |
0.453 |
|
| 2014 |
Shulman GI. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. The New England Journal of Medicine. 371: 1131-41. PMID 25229917 DOI: 10.1056/Nejmra1011035 |
0.516 |
|
| 2014 |
Kibbey RG, Choi CS, Lee HY, Cabrera O, Pongratz RL, Zhao X, Birkenfeld AL, Li C, Berggren PO, Stanley C, Shulman GI. Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release. Diabetes. 63: 4218-29. PMID 25024374 DOI: 10.2337/Db14-0783 |
0.519 |
|
| 2014 |
Szendroedi J, Yoshimura T, Phielix E, Koliaki C, Marcucci M, Zhang D, Jelenik T, Müller J, Herder C, Nowotny P, Shulman GI, Roden M. Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans. Proceedings of the National Academy of Sciences of the United States of America. 111: 9597-602. PMID 24979806 DOI: 10.1073/Pnas.1409229111 |
0.525 |
|
| 2014 |
Perry RJ, Zhang XM, Zhang D, Kumashiro N, Camporez JP, Cline GW, Rothman DL, Shulman GI. Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nature Medicine. 20: 759-63. PMID 24929951 DOI: 10.1038/Nm.3579 |
0.653 |
|
| 2014 |
Jelenik T, Séquaris G, Kaul K, Ouwens DM, Phielix E, Kotzka J, Knebel B, Weiß J, Reinbeck AL, Janke L, Nowotny P, Partke HJ, Zhang D, Shulman GI, Szendroedi J, et al. Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes. Diabetes. 63: 3856-67. PMID 24917575 DOI: 10.2337/Db13-1794 |
0.516 |
|
| 2014 |
Perry RJ, Samuel VT, Petersen KF, Shulman GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 510: 84-91. PMID 24899308 DOI: 10.1038/Nature13478 |
0.78 |
|
| 2014 |
Sajan MP, Ivey RA, Lee M, Mastorides S, Jurczak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV. PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. Molecular Endocrinology (Baltimore, Md.). 28: 1097-107. PMID 24877563 DOI: 10.1210/Me.2014-1025 |
0.605 |
|
| 2014 |
Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 510: 547-51. PMID 24870244 DOI: 10.1038/Nature13267 |
0.488 |
|
| 2014 |
Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, ... ... Shulman GI, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 510: 542-6. PMID 24847880 DOI: 10.1038/Nature13270 |
0.83 |
|
| 2014 |
Lee HY, Gattu AK, Camporez JP, Kanda S, Guigni B, Kahn M, Zhang D, Galbo T, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Choi CS, Yan Z, Williams RS, Shulman GI, et al. Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia. 57: 1232-41. PMID 24718953 DOI: 10.1007/S00125-014-3212-1 |
0.709 |
|
| 2014 |
Thorn SR, Baquero KC, Newsom SA, El Kasmi KC, Bergman BC, Shulman GI, Grove KL, Friedman JE. Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes. 63: 2702-13. PMID 24705404 DOI: 10.2337/Db14-0276 |
0.537 |
|
| 2014 |
Sajan MP, Jurzak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV. Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis. Adipocyte. 3: 19-29. PMID 24575365 DOI: 10.4161/adip.26305 |
0.486 |
|
| 2014 |
Giménez-Cassina A, Garcia-Haro L, Choi CS, Osundiji MA, Lane EA, Huang H, Yildirim MA, Szlyk B, Fisher JK, Polak K, Patton E, Wiwczar J, Godes M, Lee DH, Robertson K, ... ... Shulman GI, et al. Regulation of hepatic energy metabolism and gluconeogenesis by BAD Cell Metabolism. 19: 272-284. PMID 24506868 DOI: 10.1016/J.Cmet.2013.12.001 |
0.753 |
|
| 2014 |
Stark R, Guebre-Egziabher F, Zhao X, Feriod C, Dong J, Alves TC, Ioja S, Pongratz RL, Bhanot S, Roden M, Cline GW, Shulman GI, Kibbey RG. A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis Journal of Biological Chemistry. 289: 7257-7263. PMID 24497630 DOI: 10.1074/Jbc.C113.544759 |
0.464 |
|
| 2014 |
Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, ... ... Shulman GI, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 156: 304-16. PMID 24439384 DOI: 10.1016/J.Cell.2013.12.021 |
0.432 |
|
| 2014 |
Wheeler SG, Hammond CL, Jornayvaz FR, Samuel VT, Shulman GI, Soroka CJ, Boyer JL, Hinkle PM, Ballatori N. Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity. American Journal of Physiology. Gastrointestinal and Liver Physiology. 306: G425-38. PMID 24381083 DOI: 10.1152/Ajpgi.00368.2013 |
0.704 |
|
| 2014 |
Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer JK, Brosnan J, Rothman DL, Petersen KF, Shulman GI. Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy. Nature Medicine. 20: 98-102. PMID 24317120 DOI: 10.1038/Nm.3415 |
0.579 |
|
| 2014 |
Neuschäfer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neuschäfer-Rube A, Pfeiffer AF, Shulman GI, et al. The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes. Diabetes. 63: 1048-57. PMID 24222346 DOI: 10.2337/Db13-0749 |
0.751 |
|
| 2014 |
Birkenfeld AL, Shulman GI. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology (Baltimore, Md.). 59: 713-23. PMID 23929732 DOI: 10.1002/Hep.26672 |
0.555 |
|
| 2014 |
Shulman GI. In Vivo NMR Studies on the Mechanism of Lipid-Induced Insulin Resistance in Humans Biophysical Journal. 106: 12a. DOI: 10.1016/J.Bpj.2013.11.119 |
0.561 |
|
| 2014 |
Birkenfeld AL, Samuel VT, Shulman GI, De Cabo R, Reenan RA, Zhu C, Helfand S. I'm not Dead Yet: Flies and Mice Biophysical Journal. 106: 12a. DOI: 10.1016/J.Bpj.2013.11.118 |
0.722 |
|
| 2013 |
Perry RJ, Shulman GI. Treating fatty liver and insulin resistance. Aging. 5: 791-2. PMID 24304662 |
0.632 |
|
| 2013 |
Perry RJ, Kim T, Zhang XM, Lee HY, Pesta D, Popov VB, Zhang D, Rahimi Y, Jurczak MJ, Cline GW, Spiegel DA, Shulman GI. Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. Cell Metabolism. 18: 740-8. PMID 24206666 DOI: 10.1016/J.Cmet.2013.10.004 |
0.797 |
|
| 2013 |
Galbo T, Perry RJ, Nishimura E, Samuel VT, Quistorff B, Shulman GI. PP2A inhibition results in hepatic insulin resistance despite Akt2 activation. Aging. 5: 770-81. PMID 24150286 |
0.789 |
|
| 2013 |
Galbo T, Shulman GI. Lipid-induced hepatic insulin resistance. Aging. 5: 582-3. PMID 23929893 |
0.446 |
|
| 2013 |
Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI. Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: 12780-5. PMID 23840067 DOI: 10.1073/Pnas.1311176110 |
0.795 |
|
| 2013 |
Camporez JP, Jornayvaz FR, Petersen MC, Pesta D, Guigni BA, Serr J, Zhang D, Kahn M, Samuel VT, Jurczak MJ, Shulman GI. Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. Endocrinology. 154: 3099-109. PMID 23766126 DOI: 10.1210/En.2013-1191 |
0.772 |
|
| 2013 |
Löffler MG, Birkenfeld AL, Philbrick KM, Belman JP, Habtemichael EN, Booth CJ, Castorena CM, Choi CS, Jornayvaz FR, Gassaway BM, Lee HY, Cartee GD, Philbrick W, Shulman GI, Samuel VT, et al. Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle. The Journal of Biological Chemistry. 288: 20135-50. PMID 23744065 DOI: 10.1074/Jbc.M113.458075 |
0.729 |
|
| 2013 |
Vatner DF, Weismann D, Beddow SA, Kumashiro N, Erion DM, Liao XH, Grover GJ, Webb P, Phillips KJ, Weiss RE, Bogan JS, Baxter J, Shulman GI, Samuel VT. Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways. American Journal of Physiology. Endocrinology and Metabolism. 305: E89-100. PMID 23651850 DOI: 10.1152/Ajpendo.00573.2012 |
0.857 |
|
| 2013 |
Erion DM, Kotas ME, McGlashon J, Yonemitsu S, Hsiao JJ, Nagai Y, Iwasaki T, Murray SF, Bhanot S, Cline GW, Samuel VT, Shulman GI, Gillum MP. cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis. The Journal of Biological Chemistry. 288: 16167-76. PMID 23595987 DOI: 10.1074/Jbc.M113.460246 |
0.827 |
|
| 2013 |
Khan RS, Chokshi A, Drosatos K, Jiang H, Yu S, Harris CR, Schulze PC, Homma S, Blaner WS, Shulman GI, Huang LS, Goldberg IJ. Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy. Journal of Cardiovascular Pharmacology. 61: 345-54. PMID 23567901 DOI: 10.1097/Fjc.0B013E318283D845 |
0.322 |
|
| 2013 |
Kotas ME, Jurczak MJ, Annicelli C, Gillum MP, Cline GW, Shulman GI, Medzhitov R. Role of caspase-1 in regulation of triglyceride metabolism Proceedings of the National Academy of Sciences of the United States of America. 110: 4810-4815. PMID 23487794 DOI: 10.1073/Pnas.1301996110 |
0.68 |
|
| 2013 |
Nowotny B, Zahiragic L, Krog D, Nowotny PJ, Herder C, Carstensen M, Yoshimura T, Szendroedi J, Phielix E, Schadewaldt P, Schloot NC, Shulman GI, Roden M. Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans. Diabetes. 62: 2240-8. PMID 23454694 DOI: 10.2337/Db12-1179 |
0.557 |
|
| 2013 |
Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, ... ... Shulman GI, et al. Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance Diabetes. 62: 2183-2194. PMID 23423574 DOI: 10.2337/Db12-1311 |
0.759 |
|
| 2013 |
Camporez JP, Jornayvaz FR, Lee HY, Kanda S, Guigni BA, Kahn M, Samuel VT, Carvalho CR, Petersen KF, Jurczak MJ, Shulman GI. Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology. 154: 1021-8. PMID 23364948 DOI: 10.1210/En.2012-1989 |
0.713 |
|
| 2013 |
Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, Guebre-Egziabher F, Jurczak MJ, Kahn M, Guigni BA, Serr J, Hankin J, Murphy RC, Cline GW, Bhanot S, ... ... Shulman GI, et al. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 110: 1869-74. PMID 23302688 DOI: 10.1073/Pnas.1219456110 |
0.76 |
|
| 2013 |
Kursawe R, Caprio S, Giannini C, Narayan D, Lin A, D'Adamo E, Shaw M, Pierpont B, Cushman SW, Shulman GI. Decreased transcription of ChREBP-α/β isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia. Diabetes. 62: 837-44. PMID 23209190 DOI: 10.2337/Db12-0889 |
0.54 |
|
| 2013 |
Kumashiro N, Yoshimura T, Cantley JL, Majumdar SK, Guebre-Egziabher F, Kursawe R, Vatner DF, Fat I, Kahn M, Erion DM, Zhang XM, Zhang D, Manchem VP, Bhanot S, Gerhard GS, ... ... Shulman GI, et al. Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats Hepatology. 57: 1763-1772. PMID 23175050 DOI: 10.1002/Hep.26170 |
0.834 |
|
| 2013 |
Erion DM, Popov V, Hsiao JJ, Vatner D, Mitchell K, Yonemitsu S, Nagai Y, Kahn M, Gillum MP, Dong J, Murray SF, Manchem VP, Bhanot S, Cline GW, Shulman GI, et al. The role of the carbohydrate response element-binding protein in male fructose-fed rats Endocrinology. 154: 36-44. PMID 23161873 DOI: 10.1210/En.2012-1725 |
0.85 |
|
| 2012 |
Dominy JE, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, et al. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Molecular Cell. 48: 900-13. PMID 23142079 DOI: 10.1016/J.Molcel.2012.09.030 |
0.479 |
|
| 2012 |
Befroy DE, Rothman DL, Petersen KF, Shulman GI. ³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism. Diabetes. 61: 2669-78. PMID 23093656 DOI: 10.2337/Db12-0558 |
0.333 |
|
| 2012 |
Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel VT, Cravatt BF, Diano S, Shulman GI. Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. Proceedings of the National Academy of Sciences of the United States of America. 109: 14966-71. PMID 22912404 DOI: 10.1073/Pnas.1212887109 |
0.844 |
|
| 2012 |
Flannery C, Dufour S, Rabøl R, Shulman GI, Petersen KF. Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. Diabetes. 61: 2711-7. PMID 22829450 DOI: 10.2337/Db12-0206 |
0.482 |
|
| 2012 |
Li X, Shan J, Chang W, Kim I, Bao J, Lee HJ, Zhang X, Samuel VT, Shulman GI, Liu D, Zheng JJ, Wu D. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 109: 11402-7. PMID 22733757 DOI: 10.1073/Pnas.1205015109 |
0.714 |
|
| 2012 |
Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM. Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proceedings of the National Academy of Sciences of the United States of America. 109: 9635-40. PMID 22645355 DOI: 10.1073/Pnas.1207287109 |
0.578 |
|
| 2012 |
Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature Medicine. 18: 934-42. PMID 22561686 DOI: 10.1038/Nm.2744 |
0.576 |
|
| 2012 |
Jornayvaz FR, Shulman GI. Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance. Cell Metabolism. 15: 574-84. PMID 22560210 DOI: 10.1016/J.Cmet.2012.03.005 |
0.549 |
|
| 2012 |
Petersen KF, Dufour S, Morino K, Yoo PS, Cline GW, Shulman GI. Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes Proceedings of the National Academy of Sciences of the United States of America. 109: 8236-8240. PMID 22547801 DOI: 10.1073/Pnas.1205675109 |
0.536 |
|
| 2012 |
Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell. 148: 852-71. PMID 22385956 DOI: 10.1016/J.Cell.2012.02.017 |
0.736 |
|
| 2012 |
Morino K, Petersen KF, Sono S, Choi CS, Samuel VT, Lin A, Gallo A, Zhao H, Kashiwagi A, Goldberg IJ, Wang H, Eckel RH, Maegawa H, Shulman GI. Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes. Diabetes. 61: 877-87. PMID 22368174 DOI: 10.2337/Db11-1391 |
0.678 |
|
| 2012 |
Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 482: 179-85. PMID 22297845 DOI: 10.1038/Nature10809 |
0.395 |
|
| 2012 |
Liu W, Singh R, Choi CS, Lee HY, Keramati AR, Samuel VT, Lifton RP, Shulman GI, Mani A. Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. The Journal of Biological Chemistry. 287: 7213-23. PMID 22232553 DOI: 10.1074/Jbc.M111.286724 |
0.762 |
|
| 2012 |
Jornayvaz FR, Lee HY, Jurczak MJ, Alves TC, Guebre-Egziabher F, Guigni BA, Zhang D, Samuel VT, Silva JE, Shulman GI. Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance. Endocrinology. 153: 583-91. PMID 22147010 DOI: 10.1210/En.2011-1793 |
0.775 |
|
| 2012 |
Jurczak MJ, Lee AH, Jornayvaz FR, Lee HY, Birkenfeld AL, Guigni BA, Kahn M, Samuel VT, Glimcher LH, Shulman GI. Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. The Journal of Biological Chemistry. 287: 2558-67. PMID 22128176 DOI: 10.1074/Jbc.M111.316760 |
0.726 |
|
| 2011 |
Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, ... ... Shulman GI, et al. SirT1 regulates adipose tissue inflammation. Diabetes. 60: 3235-45. PMID 22110092 DOI: 10.2337/Db11-0616 |
0.776 |
|
| 2011 |
Banks AS, Kim-Muller JY, Mastracci TL, Kofler NM, Qiang L, Haeusler RA, Jurczak MJ, Laznik D, Heinrich G, Samuel VT, Shulman GI, Papaioannou VE, Accili D. Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metabolism. 14: 587-97. PMID 22055502 DOI: 10.1016/J.Cmet.2011.09.012 |
0.736 |
|
| 2011 |
Kotas ME, Lee HY, Gillum MP, Annicelli C, Guigni BA, Shulman GI, Medzhitov R. Impact of CD1d deficiency on metabolism. Plos One. 6: e25478. PMID 21980475 DOI: 10.1371/Journal.Pone.0025478 |
0.709 |
|
| 2011 |
Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proceedings of the National Academy of Sciences of the United States of America. 108: 16381-5. PMID 21930939 DOI: 10.1073/Pnas.1113359108 |
0.847 |
|
| 2011 |
Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, ... ... Shulman GI, et al. Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature. 477: 477-81. PMID 21892191 DOI: 10.1038/Nature10383 |
0.33 |
|
| 2011 |
Jamison RA, Stark R, Dong J, Yonemitsu S, Zhang D, Shulman GI, Kibbey RG. Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats. American Journal of Physiology. Endocrinology and Metabolism. 301: E1174-83. PMID 21862723 DOI: 10.1152/Ajpendo.00175.2011 |
0.474 |
|
| 2011 |
Birkenfeld AL, Lee HY, Majumdar S, Jurczak MJ, Camporez JP, Jornayvaz FR, Frederick DW, Guigni B, Kahn M, Zhang D, Weismann D, Arafat AM, Pfeiffer AF, Lieske S, Oyadomari S, ... ... Shulman GI, et al. Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism. The Journal of Biological Chemistry. 286: 36163-70. PMID 21832042 DOI: 10.1074/Jbc.M111.228817 |
0.749 |
|
| 2011 |
Rabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proceedings of the National Academy of Sciences of the United States of America. 108: 13705-9. PMID 21808028 DOI: 10.1073/Pnas.1110105108 |
0.559 |
|
| 2011 |
Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D. Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nature Medicine. 17: 961-7. PMID 21804540 DOI: 10.1038/Nm.2378 |
0.764 |
|
| 2011 |
Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, ... ... Shulman GI, et al. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metabolism. 14: 184-95. PMID 21803289 DOI: 10.1016/J.Cmet.2011.06.009 |
0.73 |
|
| 2011 |
Lee HY, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Kanda S, Popov V, Frederick DW, Zhang D, Guigni B, Bharadwaj KG, Choi CS, Goldberg IJ, Park JH, Petersen KF, Samuel VT, ... Shulman GI, et al. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology (Baltimore, Md.). 54: 1650-60. PMID 21793029 DOI: 10.1002/Hep.24571 |
0.837 |
|
| 2011 |
Ahmadian M, Abbott MJ, Tang T, Hudak CS, Kim Y, Bruss M, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Wang Y, Duncan RE, Kang C, Sul HS. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metabolism. 13: 739-48. PMID 21641555 DOI: 10.1016/J.Cmet.2011.05.002 |
0.689 |
|
| 2011 |
Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science (New York, N.Y.). 331: 1621-4. PMID 21436455 DOI: 10.1126/Science.1198363 |
0.725 |
|
| 2011 |
Jornayvaz FR, Birkenfeld AL, Jurczak MJ, Kanda S, Guigni BA, Jiang DC, Zhang D, Lee HY, Samuel VT, Shulman GI. Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proceedings of the National Academy of Sciences of the United States of America. 108: 5748-52. PMID 21436037 DOI: 10.1073/Pnas.1103451108 |
0.762 |
|
| 2011 |
Horvath TL, Erion DM, Elsworth JD, Roth RH, Shulman GI, Andrews ZB. GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function. Neurobiology of Disease. 43: 152-62. PMID 21406233 DOI: 10.1016/J.Nbd.2011.03.005 |
0.685 |
|
| 2011 |
Alves TC, Befroy DE, Kibbey RG, Kahn M, Codella R, Carvalho RA, Falk Petersen K, Shulman GI. Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance. Hepatology (Baltimore, Md.). 53: 1175-81. PMID 21400553 DOI: 10.1002/Hep.24170 |
0.565 |
|
| 2011 |
Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG. SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. Diabetes. 60: 890-8. PMID 21357472 DOI: 10.2337/Db10-1328 |
0.707 |
|
| 2011 |
Perfield JW, Lee Y, Shulman GI, Samuel VT, Jurczak MJ, Chang E, Xie C, Tsichlis PN, Obin MS, Greenberg AS. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes. 60: 1168-76. PMID 21346175 DOI: 10.2337/Db10-0715 |
0.688 |
|
| 2011 |
Lin HV, Ren H, Samuel VT, Lee HY, Lu TY, Shulman GI, Accili D. Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues. Diabetes. 60: 700-9. PMID 21266328 DOI: 10.2337/Db10-1056 |
0.739 |
|
| 2011 |
Ellis JM, Mentock SM, Depetrillo MA, Koves TR, Sen S, Watkins SM, Muoio DM, Cline GW, Taegtmeyer H, Shulman GI, Willis MS, Coleman RA. Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy. Molecular and Cellular Biology. 31: 1252-62. PMID 21245374 DOI: 10.1128/Mcb.01085-10 |
0.336 |
|
| 2011 |
Srisai D, Gillum MP, Panaro BL, Zhang XM, Kotchabhakdi N, Shulman GI, Ellacott KL, Cone RD. Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse. Endocrinology. 152: 890-902. PMID 21239438 DOI: 10.1210/En.2010-0716 |
0.683 |
|
| 2011 |
Weismann D, Erion DM, Ignatova-Todorava I, Nagai Y, Stark R, Hsiao JJ, Flannery C, Birkenfeld AL, May T, Kahn M, Zhang D, Yu XX, Murray SF, Bhanot S, Monia BP, ... ... Shulman GI, et al. Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance Diabetologia. 54: 935-944. PMID 21190014 DOI: 10.1007/S00125-010-1984-5 |
0.817 |
|
| 2011 |
Gillum MP, Erion DM, Shulman GI. Sirtuin-1 regulation of mammalian metabolism. Trends in Molecular Medicine. 17: 8-13. PMID 20971038 DOI: 10.1016/J.Molmed.2010.09.005 |
0.804 |
|
| 2011 |
Jornayvaz FR, Jurczak MJ, Samuel VT, Shulman GI. Reply to Monetti et al.: Hepatic steatosis and diacylglycerol-mediated hepatic insulin resistance in acyl-CoA:Diacylglycerol acyltransferase 2 (DGAT2) transgenic mice Proceedings of the National Academy of Sciences of the United States of America. 108. DOI: 10.1073/Pnas.1109195108 |
0.703 |
|
| 2011 |
Taylor R, Shulman GI. Regulation of Hepatic Glucose Uptake Comprehensive Physiology. 787-802. DOI: 10.1002/Cphy.Cp070226 |
0.517 |
|
| 2010 |
Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI. Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metabolism. 12: 668-74. PMID 21109199 DOI: 10.1016/J.Cmet.2010.11.004 |
0.684 |
|
| 2010 |
Boumezbeur F, Petersen KF, Cline GW, Mason GF, Behar KL, Shulman GI, Rothman DL. The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13983-91. PMID 20962220 DOI: 10.1523/Jneurosci.2040-10.2010 |
0.306 |
|
| 2010 |
Son NH, Yu S, Tuinei J, Arai K, Hamai H, Homma S, Shulman GI, Abel ED, Goldberg IJ. PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation. The Journal of Clinical Investigation. 120: 3443-54. PMID 20852389 DOI: 10.1172/Jci40905 |
0.342 |
|
| 2010 |
Jornayvaz FR, Jurczak MJ, Lee HY, Birkenfeld AL, Frederick DW, Zhang D, Zhang XM, Samuel VT, Shulman GI. A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain. American Journal of Physiology. Endocrinology and Metabolism. 299: E808-15. PMID 20807839 DOI: 10.1152/Ajpendo.00361.2010 |
0.761 |
|
| 2010 |
Kursawe R, Eszlinger M, Narayan D, Liu T, Bazuine M, Cali AM, D'Adamo E, Shaw M, Pierpont B, Shulman GI, Cushman SW, Sherman A, Caprio S. Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis. Diabetes. 59: 2288-96. PMID 20805387 DOI: 10.2337/Db10-0113 |
0.414 |
|
| 2010 |
Santoro N, Kursawe R, D'Adamo E, Dykas DJ, Zhang CK, Bale AE, Calí AM, Narayan D, Shaw MM, Pierpont B, Savoye M, Lartaud D, Eldrich S, Cushman SW, Zhao H, ... Shulman GI, et al. A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. Hepatology (Baltimore, Md.). 52: 1281-90. PMID 20803499 DOI: 10.1002/Hep.23832 |
0.426 |
|
| 2010 |
Brown JM, Betters JL, Lord C, Ma Y, Han X, Yang K, Alger HM, Melchior J, Sawyer J, Shah R, Wilson MD, Liu X, Graham MJ, Lee R, Crooke R, ... Shulman GI, et al. CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. Journal of Lipid Research. 51: 3306-15. PMID 20802159 DOI: 10.1194/Jlr.M010256 |
0.567 |
|
| 2010 |
Ayala JE, Samuel VT, Morton GJ, Obici S, Croniger CM, Shulman GI, Wasserman DH, McGuinness OP. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Disease Models & Mechanisms. 3: 525-34. PMID 20713647 DOI: 10.1242/Dmm.006239 |
0.644 |
|
| 2010 |
Jornayvaz FR, Samuel VT, Shulman GI. The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. Annual Review of Nutrition. 30: 273-90. PMID 20645852 DOI: 10.1146/Annurev.Nutr.012809.104726 |
0.729 |
|
| 2010 |
Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet (London, England). 375: 2267-77. PMID 20609972 DOI: 10.1016/S0140-6736(10)60408-4 |
0.765 |
|
| 2010 |
Zhang D, Christianson J, Liu ZX, Tian L, Choi CS, Neschen S, Dong J, Wood PA, Shulman GI. Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency. Cell Metabolism. 11: 402-11. PMID 20444420 DOI: 10.1016/J.Cmet.2010.03.012 |
0.54 |
|
| 2010 |
Erion DM, Shulman GI. Diacylglycerol-mediated insulin resistance. Nature Medicine. 16: 400-2. PMID 20376053 DOI: 10.1038/Nm0410-400 |
0.77 |
|
| 2010 |
Olson DP, Pulinilkunnil T, Cline GW, Shulman GI, Lowell BB. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake Proceedings of the National Academy of Sciences of the United States of America. 107: 7598-7603. PMID 20368432 DOI: 10.1073/Pnas.0913492107 |
0.367 |
|
| 2010 |
Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM, Dziura J, Lifton RP, Shulman GI. Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. The New England Journal of Medicine. 362: 1082-9. PMID 20335584 DOI: 10.1056/Nejmoa0907295 |
0.463 |
|
| 2010 |
Chutkow WA, Birkenfeld AL, Brown JD, Lee HY, Frederick DW, Yoshioka J, Patwari P, Kursawe R, Cushman SW, Plutzky J, Shulman GI, Samuel VT, Lee RT. Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes. 59: 1424-34. PMID 20299477 DOI: 10.2337/Db09-1212 |
0.734 |
|
| 2010 |
Mitchell CS, Savage DB, Dufour S, Schoenmakers N, Murgatroyd P, Befroy D, Halsall D, Northcott S, Raymond-Barker P, Curran S, Henning E, Keogh J, Owen P, Lazarus J, Rothman DL, ... ... Shulman GI, et al. Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia. The Journal of Clinical Investigation. 120: 1345-54. PMID 20237409 DOI: 10.1172/Jci38793 |
0.316 |
|
| 2010 |
Wendel AA, Li LO, Li Y, Cline GW, Shulman GI, Coleman RA. Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity. Diabetes. 59: 1321-9. PMID 20200319 DOI: 10.2337/Db09-1380 |
0.552 |
|
| 2010 |
Andrews ZB, Erion DM, Beiler R, Choi CS, Shulman GI, Horvath TL. Uncoupling protein-2 decreases the lipogenic actions of ghrelin. Endocrinology. 151: 2078-86. PMID 20189996 DOI: 10.1210/En.2009-0850 |
0.709 |
|
| 2010 |
Kursawe R, Narayan D, Cali AM, Shaw M, Pierpont B, Shulman GI, Caprio S. Downregulation of ADIPOQ and PPARγ2 gene expression in subcutaneous adipose tissue of obese adolescents with hepatic steatosis. Obesity (Silver Spring, Md.). 18: 1911-7. PMID 20168312 DOI: 10.1038/Oby.2010.23 |
0.425 |
|
| 2010 |
Bajaj M, Baig R, Suraamornkul S, Hardies LJ, Coletta DK, Cline GW, Monroy A, Koul S, Sriwijitkamol A, Musi N, Shulman GI, DeFronzo RA. Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus. The Journal of Clinical Endocrinology and Metabolism. 95: 1916-23. PMID 20157197 DOI: 10.1210/Jc.2009-0911 |
0.434 |
|
| 2009 |
Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proceedings of the National Academy of Sciences of the United States of America. 106: 22510-5. PMID 20018698 DOI: 10.1073/Pnas.0912533106 |
0.381 |
|
| 2009 |
Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, ... ... Shulman GI, et al. Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein Cell Metabolism. 10: 499-506. PMID 19945407 DOI: 10.1016/J.Cmet.2009.10.007 |
0.845 |
|
| 2009 |
Roth RJ, Le AM, Zhang L, Kahn M, Samuel VT, Shulman GI, Bennett AM. MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. The Journal of Clinical Investigation. 119: 3817-29. PMID 19920356 DOI: 10.1172/Jci39054 |
0.643 |
|
| 2009 |
Leavens KF, Easton RM, Shulman GI, Previs SF, Birnbaum MJ. Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metabolism. 10: 405-18. PMID 19883618 DOI: 10.1016/J.Cmet.2009.10.004 |
0.601 |
|
| 2009 |
Liu L, Shi X, Choi CS, Shulman GI, Klaus K, Nair KS, Schwartz GJ, Zhang Y, Goldberg IJ, Yu YH. Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1. Diabetes. 58: 2516-24. PMID 19675136 DOI: 10.2337/Db08-1096 |
0.493 |
|
| 2009 |
Li LO, Ellis JM, Paich HA, Wang S, Gong N, Altshuller G, Thresher RJ, Koves TR, Watkins SM, Muoio DM, Cline GW, Shulman GI, Coleman RA. Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. The Journal of Biological Chemistry. 284: 27816-26. PMID 19648649 DOI: 10.1074/Jbc.M109.022467 |
0.473 |
|
| 2009 |
Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, Kibbey RG. Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion Journal of Biological Chemistry. 284: 26578-26590. PMID 19635791 DOI: 10.1074/Jbc.M109.011775 |
0.455 |
|
| 2009 |
Samuel VT, Beddow SA, Iwasaki T, Zhang XM, Chu X, Still CD, Gerhard GS, Shulman GI. Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes. Proceedings of the National Academy of Sciences of the United States of America. 106: 12121-6. PMID 19587243 DOI: 10.1073/Pnas.0812547106 |
0.731 |
|
| 2009 |
Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, ... ... Shulman GI, et al. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proceedings of the National Academy of Sciences of the United States of America. 106: 11288-93. PMID 19549853 DOI: 10.1073/Pnas.0812931106 |
0.857 |
|
| 2009 |
Dufour S, Lebon V, Shulman GI, Petersen KF. Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans. American Journal of Physiology. Endocrinology and Metabolism. 297: E231-5. PMID 19458062 DOI: 10.1152/Ajpendo.00222.2009 |
0.447 |
|
| 2009 |
Befroy DE, Falk Petersen K, Rothman DL, Shulman GI. Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy. Methods in Enzymology. 457: 373-93. PMID 19426879 DOI: 10.1016/S0076-6879(09)05021-6 |
0.332 |
|
| 2009 |
Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW. Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1α and in HNF-1α-deficient islets Journal of Biological Chemistry. 284: 16808-16821. PMID 19376774 DOI: 10.1074/Jbc.M807723200 |
0.469 |
|
| 2009 |
Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes. 58: 1499-508. PMID 19366863 DOI: 10.2337/Db08-1571 |
0.476 |
|
| 2009 |
Nie Y, Erion DM, Yuan Z, Dietrich M, Shulman GI, Horvath TL, Gao Q. STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nature Cell Biology. 11: 492-500. PMID 19295512 DOI: 10.1038/Ncb1857 |
0.703 |
|
| 2009 |
Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D, Jurczak MJ, Löffler MG, Cresswell J, Yu XX, Murray SF, Bhanot S, Monia BP, ... ... Shulman GI, et al. The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metabolism. 9: 252-64. PMID 19254570 DOI: 10.1016/J.Cmet.2009.01.011 |
0.822 |
|
| 2009 |
Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nature Medicine. 15: 159-68. PMID 19136964 DOI: 10.1038/Nm.1904 |
0.684 |
|
| 2009 |
Ahmadian M, Duncan RE, Varady KA, Frasson D, Hellerstein MK, Birkenfeld AL, Samuel VT, Shulman GI, Wang Y, Kang C, Sul HS. Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity. Diabetes. 58: 855-66. PMID 19136649 DOI: 10.2337/Db08-1644 |
0.631 |
|
| 2009 |
Wang H, Knaub LA, Jensen DR, Young Jung D, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la Houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Soo Choi C, Shulman GI, Kim JK, et al. Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues. Diabetes. 58: 116-24. PMID 18952837 DOI: 10.2337/Db07-1839 |
0.47 |
|
| 2009 |
Rowe GC, Choi CS, Neff L, Horne WC, Shulman GI, Baron R. Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice. Endocrinology. 150: 135-43. PMID 18772235 DOI: 10.1210/En.2008-0678 |
0.474 |
|
| 2009 |
Samuel VT, Petersen KF, Shulman GI. Insulin Resistance The Liver: Biology and Pathobiology: Fifth Edition. 469-483. DOI: 10.1002/9780470747919.ch31 |
0.677 |
|
| 2008 |
Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, ... ... Shulman GI, et al. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 105: 19926-31. PMID 19066218 DOI: 10.1073/Pnas.0810339105 |
0.718 |
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| 2008 |
Gillum MP, Zhang D, Zhang XM, Erion DM, Jamison RA, Choi C, Dong J, Shanabrough M, Duenas HR, Frederick DW, Hsiao JJ, Horvath TL, Lo CM, Tso P, Cline GW, ... Shulman GI, et al. N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake. Cell. 135: 813-24. PMID 19041747 DOI: 10.1016/J.Cell.2008.10.043 |
0.775 |
|
| 2008 |
Befroy DE, Petersen KF, Dufour S, Mason GF, Rothman DL, Shulman GI. Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals. Proceedings of the National Academy of Sciences of the United States of America. 105: 16701-6. PMID 18936488 DOI: 10.1073/Pnas.0808889105 |
0.304 |
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| 2008 |
Villena JA, Choi CS, Wang Y, Kim S, Hwang YJ, Kim YB, Cline G, Shulman GI, Sul HS. Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (pref-1): A new model of partial lipodystrophy Diabetes. 57: 3258-3266. PMID 18835937 DOI: 10.2337/Db07-1739 |
0.546 |
|
| 2008 |
Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature. 454: 846-51. PMID 18668043 DOI: 10.1038/Nature07181 |
0.669 |
|
| 2008 |
Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI. Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes. 57: 2644-51. PMID 18633112 DOI: 10.2337/Db06-0454 |
0.841 |
|
| 2008 |
Essop MF, Camp HS, Choi CS, Sharma S, Fryer RM, Reinhart GA, Guthrie PH, Bentebibel A, Gu Z, Shulman GI, Taegtmeyer H, Wakil SJ, Abu-Elheiga L. Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice. American Journal of Physiology. Heart and Circulatory Physiology. 295: H256-65. PMID 18487439 DOI: 10.1152/Ajpheart.91489.2007 |
0.345 |
|
| 2008 |
Kim H, Taksali SE, Dufour S, Befroy D, Goodman TR, Petersen KF, Shulman GI, Caprio S, Constable RT. Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 59: 521-7. PMID 18306404 DOI: 10.1002/Mrm.21561 |
0.318 |
|
| 2008 |
Wolfgang MJ, Cha SH, Millington DS, Cline G, Shulman GI, Suwa A, Asaumi M, Kurama T, Shimokawa T, Lane MD. Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. Journal of Neurochemistry. 105: 1550-9. PMID 18248603 DOI: 10.1111/J.1471-4159.2008.05255.X |
0.359 |
|
| 2008 |
Savage DB, Zhai L, Ravikumar B, Choi CS, Snaar JE, McGuire AC, Wou SE, Medina-Gomez G, Kim S, Bock CB, Segvich DM, Solanky B, Deelchand D, Vidal-Puig A, Wareham NJ, ... Shulman GI, et al. A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. Plos Medicine. 5: e27. PMID 18232732 DOI: 10.1371/Journal.Pmed.0050027 |
0.309 |
|
| 2008 |
Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, ... ... Shulman GI, et al. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nature Medicine. 14: 144-53. PMID 18223655 DOI: 10.1038/Nm1717 |
0.442 |
|
| 2007 |
Wolfgang MJ, Cha SH, Sidhaye A, Chohnan S, Cline G, Shulman GI, Lane MD. Regulation of hypothalamic malonyl-CoA by central glucose and leptin. Proceedings of the National Academy of Sciences of the United States of America. 104: 19285-90. PMID 18032600 DOI: 10.1073/Pnas.0709778104 |
0.465 |
|
| 2007 |
Zhang D, Liu ZX, Cheol SC, Tian L, Kibbey R, Dong J, Cline GW, Wood PA, Shulman GI. Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance Proceedings of the National Academy of Sciences of the United States of America. 104: 17075-17080. PMID 17940018 DOI: 10.1073/Pnas.0707060104 |
0.574 |
|
| 2007 |
Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. The Journal of Clinical Investigation. 117: 3463-74. PMID 17932564 DOI: 10.1172/Jci31785 |
0.457 |
|
| 2007 |
Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 104: 16480-5. PMID 17923673 DOI: 10.1073/Pnas.0706794104 |
0.562 |
|
| 2007 |
Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, Schraw T, Durand JL, Li H, Li G, Jelicks LA, Mehler MF, Hui DY, Deshaies Y, Shulman GI, et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. The Journal of Clinical Investigation. 117: 2621-37. PMID 17717599 DOI: 10.1172/Jci31021 |
0.533 |
|
| 2007 |
Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M. Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. The Journal of Clinical Investigation. 117: 2289-301. PMID 17641777 DOI: 10.1172/JCI31408 |
0.464 |
|
| 2007 |
Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America. 104: 12587-94. PMID 17640906 DOI: 10.1073/Pnas.0705408104 |
0.521 |
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| 2007 |
Liska D, Dufour S, Zern TL, Taksali S, Calí AMG, Dziura J, Shulman GI, Pierpont BM, Caprio S. Interethnic differences in muscle, liver and abdominal fat partitioning in obese adolescents Plos One. 2. PMID 17593968 DOI: 10.1371/Journal.Pone.0000569 |
0.455 |
|
| 2007 |
Choi CS, Fillmore JJ, Kim JK, Liu ZX, Kim S, Collier EF, Kulkarni A, Distefano A, Hwang YJ, Kahn M, Chen Y, Yu C, Moore IK, Reznick RM, Higashimori T, ... Shulman GI, et al. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. The Journal of Clinical Investigation. 117: 1995-2003. PMID 17571165 DOI: 10.1172/Jci13579 |
0.585 |
|
| 2007 |
Cheol SC, Savage DB, Kulkarni A, Xing XY, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, ... ... Shulman GI, et al. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance Journal of Biological Chemistry. 282: 22678-22688. PMID 17526931 DOI: 10.1074/Jbc.M704213200 |
0.754 |
|
| 2007 |
Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, et al. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metabolism. 5: 383-93. PMID 17488640 DOI: 10.1016/J.Cmet.2007.04.001 |
0.323 |
|
| 2007 |
Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance Physiological Reviews. 87: 507-520. PMID 17429039 DOI: 10.1152/Physrev.00024.2006 |
0.477 |
|
| 2007 |
Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW, Shulman GI. Mitochondrial GTP regulates glucose-stimulated insulin secretion. Cell Metabolism. 5: 253-64. PMID 17403370 DOI: 10.1016/J.Cmet.2007.02.008 |
0.47 |
|
| 2007 |
Nagle CA, An J, Shiota M, Torres TP, Cline GW, Liu ZX, Wang S, Catlin RL, Shulman GI, Newgard CB, Coleman RA. Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. The Journal of Biological Chemistry. 282: 14807-15. PMID 17389595 DOI: 10.1074/Jbc.M611550200 |
0.578 |
|
| 2007 |
Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 5680-5. PMID 17372192 DOI: 10.1073/Pnas.0701179104 |
0.552 |
|
| 2007 |
Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, Kahn M, Zhang XM, Monia BP, Bhanot S, Shulman GI. Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. The Journal of Clinical Investigation. 117: 739-45. PMID 17318260 DOI: 10.1172/Jci30400 |
0.765 |
|
| 2007 |
Befroy DE, Petersen KF, Dufour S, Mason GF, de Graaf RA, Rothman DL, Shulman GI. Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes. 56: 1376-81. PMID 17287462 DOI: 10.2337/Db06-0783 |
0.507 |
|
| 2007 |
Reznick RM, Zong H, Li J, Morino K, Moore IK, Yu HJ, Liu ZX, Dong J, Mustard KJ, Hawley SA, Befroy D, Pypaert M, Hardie DG, Young LH, Shulman GI. Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metabolism. 5: 151-6. PMID 17276357 DOI: 10.1016/J.Cmet.2007.01.008 |
0.379 |
|
| 2007 |
Neschen S, Morino K, Dong J, Wang-Fischer Y, Cline GW, Romanelli AJ, Rossbacher JC, Moore IK, Regittnig W, Munoz DS, Kim JH, Shulman GI. n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner. Diabetes. 56: 1034-41. PMID 17251275 DOI: 10.2337/Db06-1206 |
0.459 |
|
| 2007 |
Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao XB, Mobbs C, Shulman GI, Diano S, Horvath TL. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nature Medicine. 13: 89-94. PMID 17195839 DOI: 10.1038/Nm1525 |
0.338 |
|
| 2007 |
Pongratz RL, Kibbey RG, Shulman GI, Cline GW. Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion. The Journal of Biological Chemistry. 282: 200-7. PMID 17102138 DOI: 10.1074/Jbc.M602954200 |
0.495 |
|
| 2007 |
Mason GF, Petersen KF, de Graaf RA, Shulman GI, Rothman DL. Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose. Journal of Neurochemistry. 100: 73-86. PMID 17076763 DOI: 10.1111/J.1471-4159.2006.04200.X |
0.305 |
|
| 2007 |
Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M. Muscle-specific knockout of PKC-λ impairs glucose transport and induces metabolic and diabetic syndromes Journal of Clinical Investigation. 117: 3141-3141. DOI: 10.1172/Jci31408C1 |
0.554 |
|
| 2006 |
Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metabolism. 4: 453-64. PMID 17141629 DOI: 10.1016/J.Cmet.2006.11.003 |
0.491 |
|
| 2006 |
Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction Diabetes. 55. PMID 17130651 DOI: 10.2337/Db06-S002 |
0.57 |
|
| 2006 |
Petersen KF, Dufour S, Feng J, Befroy D, Dziura J, Dalla Man C, Cobelli C, Shulman GI. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proceedings of the National Academy of Sciences of the United States of America. 103: 18273-7. PMID 17114290 DOI: 10.1073/Pnas.0608537103 |
0.529 |
|
| 2006 |
Chen A, Brar B, Choi CS, Rousso D, Vaughan J, Kuperman Y, Kim SN, Donaldson C, Smith SM, Jamieson P, Li C, Nagy TR, Shulman GI, Lee KF, Vale W. Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 103: 16580-5. PMID 17050686 DOI: 10.1073/Pnas.0607337103 |
0.561 |
|
| 2006 |
Sørensen H, Brand CL, Neschen S, Holst JJ, Fosgerau K, Nishimura E, Shulman GI. Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice Diabetes. 55: 2843-2848. PMID 17003351 DOI: 10.2337/Db06-0222 |
0.483 |
|
| 2006 |
Wu JJ, Roth RJ, Anderson EJ, Hong EG, Lee MK, Choi CS, Neufer PD, Shulman GI, Kim JK, Bennett AM. Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metabolism. 4: 61-73. PMID 16814733 DOI: 10.1016/J.Cmet.2006.05.010 |
0.501 |
|
| 2006 |
Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM. Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action. Diabetes. 55: 2042-50. PMID 16804074 DOI: 10.2337/Db05-0705 |
0.759 |
|
| 2006 |
Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes. 55: 1915-22. PMID 16804058 DOI: 10.2337/Db05-1496 |
0.52 |
|
| 2006 |
Reznick RM, Shulman GI. The role of AMP-activated protein kinase in mitochondrial biogenesis. The Journal of Physiology. 574: 33-9. PMID 16709637 DOI: 10.1113/Jphysiol.2006.109512 |
0.372 |
|
| 2006 |
Petersen KF, Shulman GI. New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy Obesity (Silver Spring, Md.). 14. PMID 16642961 DOI: 10.1038/Oby.2006.280 |
0.453 |
|
| 2006 |
Park SY, Cho YR, Kim HJ, Hong EG, Higashimori T, Lee SJ, Goldberg IJ, Shulman GI, Najjar SM, Kim JK. Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1. American Journal of Physiology. Endocrinology and Metabolism. 291: E517-24. PMID 16638824 DOI: 10.1152/Ajpendo.00077.2006 |
0.597 |
|
| 2006 |
Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournès B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis Nature Medicine. 12: 549-556. PMID 16617349 DOI: 10.1038/Nm1397 |
0.587 |
|
| 2006 |
Mason GF, Petersen KF, Lebon V, Rothman DL, Shulman GI. Increased brain monocarboxylic acid transport and utilization in type 1 diabetes. Diabetes. 55: 929-34. PMID 16567513 DOI: 10.2337/Diabetes.55.04.06.Db05-1325 |
0.323 |
|
| 2006 |
Neschen S, Morino K, Rossbacher JC, Pongratz RL, Cline GW, Sono S, Gillum M, Shulman GI. Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice. Diabetes. 55: 924-8. PMID 16567512 DOI: 10.2337/Diabetes.55.04.06.Db05-0985 |
0.659 |
|
| 2006 |
Petersen KF, Shulman GI. Etiology of insulin resistance American Journal of Medicine. 119. PMID 16563942 DOI: 10.1016/J.Amjmed.2006.01.009 |
0.567 |
|
| 2006 |
Savage DB, Choi CS, Samuel VT, Liu ZX, Zhang D, Wang A, Zhang XM, Cline GW, Yu XX, Geisler JG, Bhanot S, Monia BP, Shulman GI. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. The Journal of Clinical Investigation. 116: 817-24. PMID 16485039 DOI: 10.1172/Jci27300 |
0.756 |
|
| 2006 |
Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, Scherer PE, Bernlohr DA. Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. American Journal of Physiology. Endocrinology and Metabolism. 290: E814-23. PMID 16303844 DOI: 10.1152/Ajpendo.00465.2005 |
0.457 |
|
| 2006 |
Bilz S, Samuel V, Morino K, Savage D, Cheol SC, Shulman GI. Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters American Journal of Physiology - Endocrinology and Metabolism. 290. PMID 16291572 DOI: 10.1152/Ajpendo.00355.2005 |
0.67 |
|
| 2005 |
Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M, Shulman GI. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. The Journal of Clinical Investigation. 115: 3587-93. PMID 16284649 DOI: 10.1172/Jci25151 |
0.513 |
|
| 2005 |
Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, DeFronzo RA. Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty acyl-CoAs and insulin action in type 2 diabetic patients Diabetes. 54: 3148-3153. PMID 16249438 DOI: 10.2337/Diabetes.54.11.3148 |
0.461 |
|
| 2005 |
Petersen KF, Dufour S, Shulman GI. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents Plos Medicine. 2: 0879-0884. PMID 16089501 DOI: 10.1371/Journal.Pmed.0020233 |
0.518 |
|
| 2005 |
Neschen S, Morino K, Hammond LE, Zhang D, Liu ZX, Romanelli AJ, Cline GW, Pongratz RL, Zhang XM, Choi CS, Coleman RA, Shulman GI. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Cell Metabolism. 2: 55-65. PMID 16054099 DOI: 10.1016/J.Cmet.2005.06.006 |
0.583 |
|
| 2005 |
Kim JK, Kim HJ, Park SY, Cederberg A, Westergren R, Nilsson D, Higashimori T, Cho YR, Liu ZX, Dong J, Cline GW, Enerback S, Shulman GI. Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance Diabetes. 54: 1657-1663. PMID 15919786 DOI: 10.2337/Diabetes.54.6.1657 |
0.585 |
|
| 2005 |
Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA. Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs. The Journal of Biological Chemistry. 280: 25629-36. PMID 15878874 DOI: 10.1074/Jbc.M503181200 |
0.476 |
|
| 2005 |
Savage DB, Petersen KF, Shulman GI. Mechanisms of insulin resistance in humans and possible links with inflammation Hypertension. 45: 828-833. PMID 15824195 DOI: 10.1161/01.Hyp.0000163475.04421.E4 |
0.57 |
|
| 2005 |
Weiss R, Taksali SE, Dufour S, Yeckel CW, Papademetris X, Cline G, Tamborlane WV, Dziura J, Shulman GI, Caprio S. The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning. The Journal of Clinical Endocrinology and Metabolism. 90: 3731-7. PMID 15797955 DOI: 10.1210/Jc.2004-2305 |
0.474 |
|
| 2005 |
Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE, Shulman GI. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes Diabetes. 54: 603-608. PMID 15734833 DOI: 10.2337/Diabetes.54.3.603 |
0.502 |
|
| 2005 |
Park SY, Kim HJ, Wang S, Higashimori T, Dong J, Kim YJ, Cline G, Li H, Prentki M, Shulman GI, Mitchell GA, Kim JK. Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart American Journal of Physiology - Endocrinology and Metabolism. 289: E30-E39. PMID 15701680 DOI: 10.1152/Ajpendo.00251.2004 |
0.576 |
|
| 2005 |
Kernan WN, Viscoli CM, Inzucchi SE, Brass LM, Bravata DM, Shulman GI, McVeety JC. Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke Archives of Internal Medicine. 165: 227-233. PMID 15668371 DOI: 10.1001/Archinte.165.2.227 |
0.367 |
|
| 2005 |
Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science (New York, N.Y.). 307: 384-7. PMID 15662004 DOI: 10.1126/Science.1104343 |
0.524 |
|
| 2004 |
Krssak M, Brehm A, Bernroider E, Anderwald C, Nowotny P, Dalla Man C, Cobelli C, Cline GW, Shulman GI, Waldhäusl W, Roden M. Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes Diabetes. 53: 3048-3056. PMID 15561933 DOI: 10.2337/Diabetes.53.12.3048 |
0.462 |
|
| 2004 |
Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, ... ... Shulman GI, et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 119: 121-35. PMID 15454086 DOI: 10.1016/J.Cell.2004.09.013 |
0.366 |
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| 2004 |
Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline GW, O'Brien WR, Littman DR, Shulman GI. PKC-theta knockout mice are protected from fat-induced insulin resistance. The Journal of Clinical Investigation. 114: 823-7. PMID 15372106 DOI: 10.1172/Jci22230 |
0.573 |
|
| 2004 |
Shulman GI. Unraveling the cellular mechanism of insulin resistance in humans: New insights from magnetic resonance spectroscopy Physiology. 19: 183-190. PMID 15304632 DOI: 10.1152/Physiol.00007.2004 |
0.453 |
|
| 2004 |
Cline GW, Lepine RL, Papas KK, Kibbey RG, Shulman GI. 13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells. The Journal of Biological Chemistry. 279: 44370-5. PMID 15304488 DOI: 10.1074/Jbc.M311842200 |
0.498 |
|
| 2004 |
Short KR, Nair KS, Stump CS, Bajaj M, Mandarino LJ, Raubenheimer PJ, Möhlig M, Isken F, Ristow M, Petersen KF, Shulman GI. Impaired mitochondrial activity and insulin-resistant offspring of patients with type 2 diabetes [5] (multiple letters) New England Journal of Medicine. 350: 2419-2421. PMID 15179701 DOI: 10.1056/Nejm200406033502320 |
0.447 |
|
| 2004 |
Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. The Journal of Biological Chemistry. 279: 32345-53. PMID 15166226 DOI: 10.1074/Jbc.M313478200 |
0.771 |
|
| 2004 |
Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI, Fu XY. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proceedings of the National Academy of Sciences of the United States of America. 101: 4661-6. PMID 15070774 DOI: 10.1073/Pnas.0303992101 |
0.347 |
|
| 2004 |
Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, Kahn BB. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action Journal of Biological Chemistry. 279: 24844-24851. PMID 15031294 DOI: 10.1074/Jbc.M310688200 |
0.552 |
|
| 2004 |
Shen Q, Cline GW, Shulman GI, Leibowitz MD, Davies PJA. Effects of Rexinoids on Glucose Transport and Insulin-mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice Journal of Biological Chemistry. 279: 19721-19731. PMID 14998989 DOI: 10.1074/Jbc.M311729200 |
0.548 |
|
| 2004 |
Kim JK, Gimeno RE, Higashimori T, Kim HJ, Choi H, Punreddy S, Mozell RL, Tan G, Stricker-Krongrad A, Hirsch DJ, Fillmore JJ, Liu ZX, Dong J, Cline G, Stahl A, ... ... Shulman GI, et al. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle Journal of Clinical Investigation. 113: 756-763. PMID 14991074 DOI: 10.1172/Jci18917 |
0.563 |
|
| 2004 |
Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes New England Journal of Medicine. 350: 664-671. PMID 14960743 DOI: 10.1056/Nejmoa031314 |
0.559 |
|
| 2004 |
An J, Muoio DM, Shiota M, Fujimoto Y, Cline GW, Shulman GI, Koves TR, Stevens R, Millington D, Newgard CB. Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance Nature Medicine. 10: 268-274. PMID 14770177 DOI: 10.1038/Nm995 |
0.559 |
|
| 2004 |
Erol E, Kumar LS, Cline GW, Shulman GI, Kelly DP, Binas B. Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 347-349. PMID 14656998 DOI: 10.1096/Fj.03-0330Fje |
0.38 |
|
| 2004 |
Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. 26 IMPAIRED MITOCHONDRIAL ACTIVITY IN INSULIN RESISTANT OFFSPRING OF TYPE 2 DIABETICS. Journal of Investigative Medicine. 52: S381.3-S381. DOI: 10.1136/Jim-52-Suppl2-100 |
0.455 |
|
| 2003 |
Perseghin G, Petersen K, Shulman GI. Cellular mechanism of insulin resistance: Potential links with inflammation International Journal of Obesity. 27: S6-S11. PMID 14704736 DOI: 10.1038/Sj.Ijo.0802491 |
0.579 |
|
| 2003 |
Rangwala SM, Rhoades B, Shapiro JS, Rich AS, Kim JK, Shulman GI, Kaestner KH, Lazar MA. Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Developmental Cell. 5: 657-63. PMID 14536066 DOI: 10.1016/S1534-5807(03)00274-0 |
0.517 |
|
| 2003 |
Weiss R, Dufour S, Taksali SE, Tamborlane WV, Petersen KF, Bonadonna RC, Boselli L, Barbetta G, Allen K, Rife F, Savoye M, Dziura J, Sherwin R, Shulman GI, Caprio S. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. Lancet (London, England). 362: 951-7. PMID 14511928 DOI: 10.1016/S0140-6736(03)14364-4 |
0.486 |
|
| 2003 |
Spurlin BA, Thomas RM, Nevins AK, Kim HJ, Kim YJ, Noh HL, Shulman GI, Kim JK, Thurmond DC. Insulin resistance in tetracycline-repressible Munc18c transgenic mice. Diabetes. 52: 1910-7. PMID 12882905 DOI: 10.2337/Diabetes.52.8.1910 |
0.559 |
|
| 2003 |
Wenk MR, Lucast L, Di Paolo G, Romanelli AJ, Suchy SF, Nussbaum RL, Cline GW, Shulman GI, McMurray W, De Camilli P. Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry. Nature Biotechnology. 21: 813-7. PMID 12808461 DOI: 10.1038/Nbt837 |
0.307 |
|
| 2003 |
Kim JK, Fillmore JJ, Gavrilova O, Chao L, Higashimori T, Choi H, Kim HJ, Yu C, Chen Y, Qu X, Haluzik M, Reitman ML, Shulman GI. Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice. Diabetes. 52: 1311-8. PMID 12765938 DOI: 10.2337/Diabetes.52.6.1311 |
0.574 |
|
| 2003 |
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science (New York, N.Y.). 300: 1140-2. PMID 12750520 DOI: 10.1126/Science.1082889 |
0.549 |
|
| 2003 |
Kernan WN, Inzucchi SE, Viscoli CM, Brass LM, Bravata DM, Shulman GI, McVeety JC, Horwitz RI. Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke Neurology. 60: 1447-1451. PMID 12743229 DOI: 10.1212/01.Wnl.0000063318.66140.A3 |
0.42 |
|
| 2003 |
Kernan WN, Inzucchi SE, Viscoli CM, Brass LM, Bravata DM, Shulman GI, McVeety JC, Horwitz RI. Pioglitazone improves insulin sensitivity among nondiabetic patients with a recent transient ischemic attack or ischemic stroke Stroke. 34: 1431-1436. PMID 12730556 DOI: 10.1161/01.Str.0000071108.00234.0E |
0.463 |
|
| 2003 |
Weiss R, Dufour S, Groszmann A, Petersen K, Dziura J, Taksali SE, Shulman G, Caprio S. Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation. The Journal of Clinical Endocrinology and Metabolism. 88: 2014-8. PMID 12727947 DOI: 10.1210/Jc.2002-021711 |
0.416 |
|
| 2003 |
Enoksson S, Caprio SK, Rife F, Shulman GI, Tamborlane WV, Sherwin RS. Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia. The Journal of Clinical Endocrinology and Metabolism. 88: 1503-11. PMID 12679430 DOI: 10.1210/Jc.2002-021013 |
0.442 |
|
| 2003 |
Hulver MW, Berggren JR, Cortright RN, Dudek RW, Thompson RP, Pories WJ, MacDonald KG, Cline GW, Shulman GI, Dohm GL, Houmard JA. Skeletal muscle lipid metabolism with obesity American Journal of Physiology - Endocrinology and Metabolism. 284: E741-E747. PMID 12626325 DOI: 10.1152/Ajpendo.00514.2002 |
0.319 |
|
| 2003 |
Borg MA, Tamborlane WV, Shulman GI, Sherwin RS. Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation. Diabetes. 52: 663-6. PMID 12606506 DOI: 10.2337/Diabetes.52.3.663 |
0.408 |
|
| 2002 |
Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proceedings of the National Academy of Sciences of the United States of America. 99: 15983-7. PMID 12444247 DOI: 10.1073/Pnas.252625599 |
0.352 |
|
| 2002 |
McCrimmon RJ, Evans ML, Jacob RJ, Fan X, Zhu Y, Shulman GI, Sherwin RS. AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat. American Journal of Physiology. Endocrinology and Metabolism. 283: E1076-83. PMID 12376337 DOI: 10.1152/Ajpendo.00195.2002 |
0.427 |
|
| 2002 |
Houmard JA, Tanner CJ, Yu C, Cunningham PG, Pories WJ, MacDonald KG, Shulman GI. Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects. Diabetes. 51: 2959-63. PMID 12351433 DOI: 10.2337/Diabetes.51.10.2959 |
0.48 |
|
| 2002 |
Cline GW, Johnson K, Regittnig W, Perret P, Tozzo E, Xiao L, Damico C, Shulman GI. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats Diabetes. 51: 2903-2910. PMID 12351425 DOI: 10.2337/Diabetes.51.10.2903 |
0.522 |
|
| 2002 |
Petersen KF, Shulman GI. Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus American Journal of Cardiology. 90. PMID 12231074 DOI: 10.1016/S0002-9149(02)02554-7 |
0.565 |
|
| 2002 |
Petersen KF, Shulman GI. Cellular mechanism of insulin resistance in skeletal muscle Journal of the Royal Society of Medicine, Supplement. 95: 8-13. PMID 12216329 |
0.359 |
|
| 2002 |
Kim YB, Shulman GI, Kahn BB. Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C Νζ but not on glycogen synthase kinase-3 Journal of Biological Chemistry. 277: 32915-32922. PMID 12095990 DOI: 10.1074/Jbc.M204710200 |
0.503 |
|
| 2002 |
Haluzik M, Dietz KR, Kim JK, Marcus-Samuels B, Shulman GI, Gavrilova O, Reitman ML. Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity. Diabetes. 51: 2113-8. PMID 12086940 DOI: 10.2337/Diabetes.51.7.2113 |
0.547 |
|
| 2002 |
Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and β-cell dysfunction European Journal of Clinical Investigation. 32: 14-23. PMID 12028371 DOI: 10.1046/J.1365-2362.32.S3.3.X |
0.589 |
|
| 2002 |
Petersen KF, Oral EA, Dufour S, Befroy D, Ariyan C, Yu C, Cline GW, DePaoli AM, Taylor SI, Gorden P, Shulman GI. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. The Journal of Clinical Investigation. 109: 1345-50. PMID 12021250 DOI: 10.1172/Jci15001 |
0.576 |
|
| 2002 |
Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. The Journal of Clinical Investigation. 109: 1321-6. PMID 12021247 DOI: 10.1172/Jci14955 |
0.539 |
|
| 2002 |
Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. The Journal of Biological Chemistry. 277: 50230-6. PMID 12006582 DOI: 10.1074/Jbc.M200958200 |
0.497 |
|
| 2002 |
Sinha R, Dufour S, Petersen KF, LeBon V, Enoksson S, Ma YZ, Savoye M, Rothman DL, Shulman GI, Caprio S. Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes. 51: 1022-7. PMID 11916921 DOI: 10.2337/Diabetes.51.4.1022 |
0.46 |
|
| 2002 |
Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, Enocksson S, Inzucchi SE, Shulman GI, Petersen KF. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes Diabetes. 51: 797-802. PMID 11872682 DOI: 10.2337/Diabetes.51.3.797 |
0.568 |
|
| 2002 |
Shiota M, Moore MC, Galassetti P, Monohan M, Neal DW, Shulman GI, Cherrington AD. Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog. Diabetes. 51: 469-78. PMID 11812757 DOI: 10.2337/Diabetes.51.2.469 |
0.353 |
|
| 2002 |
Neschen S, Moore I, Regittnig W, Yu CL, Wang Y, Pypaert M, Petersen KF, Shulman GI. Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content. American Journal of Physiology. Endocrinology and Metabolism. 282: E395-401. PMID 11788372 DOI: 10.1152/Ajpendo.00414.2001 |
0.421 |
|
| 2002 |
Bischof MG, Bernroider E, Krssak M, Krebs M, Stingl H, Nowotny P, Yu C, Shulman GI, Waldhäusl W, Roden M. Hepatic glycogen metabolism in type 1 diabetes after long-term near normoglycemia. Diabetes. 51: 49-54. PMID 11756322 DOI: 10.2337/Diabetes.51.1.49 |
0.476 |
|
| 2001 |
Papas KK, Colton CK, Gounarides JS, Roos ES, Jarema MA, Shapiro MJ, Cheng LL, Cline GW, Shulman GI, Wu H, Bonner-Weir S, Weir GC. NMR spectroscopy in beta cell engineering and islet transplantation. Annals of the New York Academy of Sciences. 944: 96-119. PMID 11797699 DOI: 10.1111/J.1749-6632.2001.Tb03826.X |
0.329 |
|
| 2001 |
Bergeron R, Ren JM, Cadman KS, Moore IK, Perret P, Pypaert M, Young LH, Semenkovich CF, Shulman GI. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. American Journal of Physiology. Endocrinology and Metabolism. 281: E1340-6. PMID 11701451 DOI: 10.1152/Ajpendo.2001.281.6.E1340 |
0.33 |
|
| 2001 |
Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, Slezak LA, Cline GW, Rothman DL, Shulman GI. Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle. The Journal of Clinical Investigation. 108: 733-7. PMID 11544279 DOI: 10.1172/Jci11775 |
0.31 |
|
| 2001 |
Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI. Prevention of fat-induced insulin resistance by salicylate. The Journal of Clinical Investigation. 108: 437-46. PMID 11489937 DOI: 10.1172/Jci11559 |
0.566 |
|
| 2001 |
Fernández AM, Kim JK, Yakar S, Dupont J, Hernandez-Sanchez C, Castle AL, Filmore J, Shulman GI, Le Roith D. Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes & Development. 15: 1926-34. PMID 11485987 DOI: 10.1101/Gad.908001 |
0.51 |
|
| 2001 |
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes Cell. 105: 745-755. PMID 11440717 DOI: 10.1016/S0092-8674(01)00378-6 |
0.539 |
|
| 2001 |
Kim JK, Zisman A, Fillmore JJ, Peroni OD, Kotani K, Perret P, Zong H, Dong J, Kahn CR, Kahn BB, Shulman GI. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. The Journal of Clinical Investigation. 108: 153-60. PMID 11435467 DOI: 10.1172/Jci10294 |
0.543 |
|
| 2001 |
Kim JK, Fillmore JJ, Chen Y, Yu C, Moore IK, Pypaert M, Lutz EP, Kako Y, Velez-Carrasco W, Goldberg IJ, Breslow JL, Shulman GI. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 98: 7522-7. PMID 11390966 DOI: 10.1073/Pnas.121164498 |
0.603 |
|
| 2001 |
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ) Science. 292: 1728-1731. PMID 11387480 DOI: 10.1126/Science.292.5522.1728 |
0.545 |
|
| 2001 |
Yang C, Coker KJ, Kim JK, Mora S, Thurmond DC, Davis AC, Yang B, Williamson RA, Shulman GI, Pessin JE. Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance. The Journal of Clinical Investigation. 107: 1311-8. PMID 11375421 DOI: 10.1172/Jci12274 |
0.538 |
|
| 2001 |
Petersen KF, Laurent D, Yu C, Cline GW, Shulman GI. Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans Diabetes. 50: 1263-1268. PMID 11375325 DOI: 10.2337/Diabetes.50.6.1263 |
0.466 |
|
| 2001 |
Bergeron R, Previs SF, Cline GW, Perret P, Russell RR, Young LH, Shulman GI. Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Diabetes. 50: 1076-82. PMID 11334411 DOI: 10.2337/Diabetes.50.5.1076 |
0.535 |
|
| 2001 |
Petersen KF, Cline GW, Gerard DP, Magnusson I, Rothman DL, Shulman GI. Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans. Metabolism: Clinical and Experimental. 50: 598-601. PMID 11319724 DOI: 10.1053/Meta.2001.22561 |
0.463 |
|
| 2001 |
Zabolotny JM, Kim YB, Peroni OD, Kim JK, Pani MA, Boss O, Klaman LD, Kamatkar S, Shulman GI, Kahn BB, Neel BG. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance Proceedings of the National Academy of Sciences of the United States of America. 98: 5187-5192. PMID 11309481 DOI: 10.1073/Pnas.071050398 |
0.561 |
|
| 2001 |
Cline GW, Vidal-Puig AJ, Dufour S, Cadman KS, Lowell BB, Shulman GI. In Vivo Effects of Uncoupling Protein-3 Gene Disruption on Mitochondrial Energy Metabolism Journal of Biological Chemistry. 276: 20240-20244. PMID 11274222 DOI: 10.1074/Jbc.M102540200 |
0.342 |
|
| 2001 |
Roden M, Petersen KF, Shulman GI. Nuclear magnetic resonance studies of hepatic glucose metabolism in humans Recent Progress in Hormone Research. 56: 219-237. PMID 11237214 DOI: 10.1210/rp.56.1.219 |
0.402 |
|
| 2001 |
Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 409: 729-33. PMID 11217863 DOI: 10.1038/35055575 |
0.575 |
|
| 2001 |
Stingl H, Krssák M, Krebs M, Bischof MG, Nowotny P, Fürnsinn C, Shulman GI, Waldhäusl W, Roden M. Lipid-dependent control of hepatic glycogen stores in healthy humans. Diabetologia. 44: 48-54. PMID 11206411 DOI: 10.1007/S001250051579 |
0.404 |
|
| 2001 |
Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF. Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. The Journal of Clinical Investigation. 107: 181-9. PMID 11160134 DOI: 10.1172/Jci10934 |
0.437 |
|
| 2001 |
Young L, Russell R, Coven D, Shulman G, Sinusas A. Activation of glucose transport in the ischemic heart: Translocation of GLUT4 and GLUT1 by 5′-AMP-activated protein kinase Journal of Molecular and Cellular Cardiology. 33: A145. DOI: 10.1016/S0022-2828(01)90556-5 |
0.349 |
|
| 2000 |
Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, Chandramouli V, Inzucchi SE, Schumann WC, Petersen KF, Landau BR, Shulman GI. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes. 49: 2063-9. PMID 11118008 DOI: 10.2337/Diabetes.49.12.2063 |
0.382 |
|
| 2000 |
Jucker BM, Ren J, Dufour S, Cao X, Previs SF, Cadman KS, Shulman GI. 13C/31P NMR assessment of mitochondrial energy coupling in skeletal muscle of awake fed and fasted rats. Relationship with uncoupling protein 3 expression. The Journal of Biological Chemistry. 275: 39279-86. PMID 10995775 DOI: 10.1074/Jbc.M007760200 |
0.34 |
|
| 2000 |
Previs SF, Withers DJ, Ren JM, White MF, Shulman GI. Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo Journal of Biological Chemistry. 275: 38990-38994. PMID 10995761 DOI: 10.1074/Jbc.M006490200 |
0.572 |
|
| 2000 |
Petersen KF, Krssak M, Inzucchi S, Cline GW, Dufour S, Shulman GI. Mechanism of troglitazone action in type 2 diabetes Diabetes. 49: 827-831. PMID 10905493 DOI: 10.2337/Diabetes.49.5.827 |
0.467 |
|
| 2000 |
Roden M, Stingl H, Chandramouli V, Schumann WC, Hofer A, Landau BR, Nowotny P, Waldhäusl W, Shulman GI. Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes. 49: 701-7. PMID 10905476 DOI: 10.2337/Diabetes.49.5.701 |
0.454 |
|
| 2000 |
Shulman GI. Cellular mechanisms of insulin resistance Journal of Clinical Investigation. 106: 171-176. PMID 10903330 DOI: 10.1172/Jci10583 |
0.526 |
|
| 2000 |
McNulty PH, Cline GW, Whiting JM, Shulman GI. Regulation of myocardial [13C]glucose metabolism in conscious rats American Journal of Physiology - Heart and Circulatory Physiology. 279: H375-H381. PMID 10899078 DOI: 10.1152/Ajpheart.2000.279.1.H375 |
0.453 |
|
| 2000 |
Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice Molecular and Cellular Biology. 20: 5479-5489. PMID 10891488 DOI: 10.1128/Mcb.20.15.5479-5489.2000 |
0.511 |
|
| 2000 |
Kim JK, Michael MD, Previs SF, Peroni OD, Mauvais-Jarvis F, Neschen S, Kahn BB, Kahn CR, Shulman GI. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle Journal of Clinical Investigation. 105: 1791-1797. PMID 10862794 DOI: 10.1172/Jci8305 |
0.556 |
|
| 2000 |
Jucker BM, Dufour S, Ren J, Cao X, Previs SF, Underhill B, Cadman KS, Shulman GI. Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR. Proceedings of the National Academy of Sciences of the United States of America. 97: 6880-4. PMID 10823916 DOI: 10.1073/Pnas.120131997 |
0.324 |
|
| 2000 |
Laurent D, Hundal RS, Dresner A, Price TB, Vogel SM, Petersen KF, Shulman GI. Mechanism of muscle glycogen autoregulation in humans. American Journal of Physiology. Endocrinology and Metabolism. 278: E663-8. PMID 10751200 DOI: 10.1152/Ajpendo.2000.278.4.E663 |
0.421 |
|
| 2000 |
Ren JM, Barucci N, Marshall BA, Hansen P, Mueckler MM, Shulman GI. Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after exercise American Journal of Physiology - Endocrinology and Metabolism. 278. PMID 10751190 DOI: 10.1152/Ajpendo.2000.278.4.E588 |
0.329 |
|
| 2000 |
Kim JK, Gavrilova O, Chen Y, Reitman ML, Shulman GI. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice Journal of Biological Chemistry. 275: 8456-8460. PMID 10722680 DOI: 10.1074/Jbc.275.12.8456 |
0.586 |
|
| 2000 |
McNulty PH, Jagasia D, Cline GW, Ng CK, Whiting JM, Garg P, Shulman GI, Soufer R. Persistent changes in myocardial glucose metabolism in vivo during reperfusion of a limited-duration coronary occlusion. Circulation. 101: 917-22. PMID 10694532 DOI: 10.1161/01.Cir.101.8.917 |
0.318 |
|
| 2000 |
Krssak M, Petersen KF, Bergeron R, Price T, Laurent D, Rothman DL, Roden M, Shulman GI. Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. The Journal of Clinical Endocrinology and Metabolism. 85: 748-54. PMID 10690886 DOI: 10.1210/Jcem.85.2.6354 |
0.307 |
|
| 2000 |
Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, Vinson C, Eckhaus M, Reitman ML. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. The Journal of Clinical Investigation. 105: 271-8. PMID 10675352 DOI: 10.1172/Jci7901 |
0.452 |
|
| 2000 |
Michael M, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn C. Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction Molecular Cell. 6: 87-97. DOI: 10.1016/S1097-2765(05)00015-8 |
0.59 |
|
| 1999 |
Young LH, Russell RR, Yin R, Caplan MJ, Ren J, Bergeron R, Shulman GI, Sinusas AJ. Regulation of myocardial glucose uptake and transport during ischemia and energetic stress. The American Journal of Cardiology. 83: 25H-30H. PMID 10750583 DOI: 10.1016/S0002-9149(99)00253-2 |
0.381 |
|
| 1999 |
Jucker BM, Barucci N, Shulman GI. Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle. The American Journal of Physiology. 277: E505-12. PMID 10484363 DOI: 10.1152/Ajpendo.1999.277.3.E505 |
0.467 |
|
| 1999 |
Russell RR, Bergeron R, Shulman GI, Young LH. Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. The American Journal of Physiology. 277: H643-9. PMID 10444490 DOI: 10.1152/Ajpheart.1999.277.2.H643 |
0.48 |
|
| 1999 |
Shulman GI. Cellular mechanisms of insulin resistance in humans American Journal of Cardiology. 84. PMID 10418851 DOI: 10.1016/S0002-9149(99)00350-1 |
0.583 |
|
| 1999 |
Cline GW, Petersen KF, Krssak M, Shen J, Hundal RS, Trajanoski Z, Inzucchi S, Dresner A, Rothman DL, Shulman GI. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. The New England Journal of Medicine. 341: 240-6. PMID 10413736 DOI: 10.1056/Nejm199907223410404 |
0.507 |
|
| 1999 |
Previs SF, Cline GW, Shulman GI. A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo American Journal of Physiology - Endocrinology and Metabolism. 277. PMID 10409139 DOI: 10.1152/Ajpendo.1999.277.1.E154 |
0.319 |
|
| 1999 |
Shen J, Petersen KF, Behar KL, Brown P, Nixon TW, Mason GF, Petroff OA, Shulman GI, Shulman RG, Rothman DL. Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proceedings of the National Academy of Sciences of the United States of America. 96: 8235-40. PMID 10393978 DOI: 10.1073/Pnas.96.14.8235 |
0.318 |
|
| 1999 |
Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes. 48: 1270-4. PMID 10342815 DOI: 10.2337/Diabetes.48.6.1270 |
0.567 |
|
| 1999 |
Bergeron R, Russell RR, Young LH, Ren JM, Marcucci M, Lee A, Shulman GI. Effect of AMPK activation on muscle glucose metabolism in conscious rats. The American Journal of Physiology. 276: E938-44. PMID 10329989 DOI: 10.1152/Ajpendo.1999.276.5.E938 |
0.487 |
|
| 1999 |
Borg MA, Borg WP, Tamborlane WV, Brines ML, Shulman GI, Sherwin RS. Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats. Diabetes. 48: 584-7. PMID 10078560 DOI: 10.2337/Diabetes.48.3.584 |
0.378 |
|
| 1999 |
Roden M, Shulman GI. Applications of NMR spectroscopy to study muscle glycogen metabolism in man Annual Review of Medicine. 50: 277-290. PMID 10073278 DOI: 10.1146/annurev.med.50.1.277 |
0.461 |
|
| 1999 |
Petersen KF, Krssak M, Navarro V, Chandramouli V, Hundal R, Schumann WC, Landau BR, Shulman GI. Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis. The American Journal of Physiology. 276: E529-35. PMID 10070020 DOI: 10.1152/Ajpendo.1999.276.3.E529 |
0.449 |
|
| 1999 |
Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, Roden M, Shulman GI. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 42: 113-6. PMID 10027589 DOI: 10.1007/S001250051123 |
0.455 |
|
| 1999 |
Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. The Journal of Clinical Investigation. 103: 253-9. PMID 9916137 DOI: 10.1172/Jci5001 |
0.523 |
|
| 1999 |
Jucker BM, Cline GW, Barucci N, Shulman GI. Differential effects of safflower oil versus fish oil feeding on insulin-stimulated glycogen synthesis, glycolysis, and pyruvate dehydrogenase flux in skeletal muscle: a 13C nuclear magnetic resonance study. Diabetes. 48: 134-40. PMID 9892234 DOI: 10.2337/Diabetes.48.1.134 |
0.36 |
|
| 1998 |
Laurent D, Petersen KF, Russell RR, Cline GW, Shulman GI. Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans. American Journal of Physiology. Endocrinology and Metabolism. 274: E130-E138. PMID 29590981 DOI: 10.1152/ajpendo.1998.274.1.E130 |
0.353 |
|
| 1998 |
Robinson C, Tamborlane WV, Maggs DG, Enoksson S, Sherwin RS, Silver D, Shulman GI, Caprio S. Effect of insulin on glycerol production in obese adolescents. American Journal of Physiology. Endocrinology and Metabolism. 274: E737-E743. PMID 29585576 DOI: 10.1152/ajpendo.1998.274.4.E737 |
0.318 |
|
| 1998 |
Russell RR, Yin R, Caplan MJ, Hu X, Ren J, Shulman GI, Sinusas AJ, Young LH. Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo. Circulation. 98: 2180-6. PMID 9815873 DOI: 10.1161/01.Cir.98.20.2180 |
0.45 |
|
| 1998 |
Robinson C, Tamborlane WV, Maggs DG, Enoksson S, Sherwin RS, Silver D, Shulman GI, Caprio S. Effect of insulin on glycerol production in obese adolescents. The American Journal of Physiology. 274: E737-43. PMID 9575836 DOI: 10.1152/Ajpendo.1998.274.4.E737 |
0.431 |
|
| 1998 |
Ren JM, Li PM, Zhang WR, Sweet LJ, Cline G, Shulman GI, Livingston JN, Goldstein BJ. Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis. Diabetes. 47: 493-7. PMID 9519761 DOI: 10.2337/Diabetes.47.3.493 |
0.576 |
|
| 1998 |
Petersen KF, Hendler R, Price T, Perseghin G, Rothman DL, Held N, Amatruda JM, Shulman GI. 13C/31P NMR studies on the mechanism of insulin resistance in obesity. Diabetes. 47: 381-6. PMID 9519743 DOI: 10.2337/Diabetes.47.3.381 |
0.447 |
|
| 1998 |
Inzucchi SE, Maggs DG, Spollett GR, Page SL, Rife FS, Walton V, Shulman GI. Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus New England Journal of Medicine. 338: 867-872. PMID 9516221 DOI: 10.1056/Nejm199803263381303 |
0.395 |
|
| 1998 |
Petersen KF, Laurent D, Rothman DL, Cline GW, Shulman GI. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. The Journal of Clinical Investigation. 101: 1203-9. PMID 9502760 DOI: 10.1172/Jci579 |
0.446 |
|
| 1998 |
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF. Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 391: 900-4. PMID 9495343 DOI: 10.1038/36116 |
0.54 |
|
| 1998 |
Cline GW, Jucker BM, Trajanoski Z, Rennings AJ, Shulman GI. A novel 13C NMR method to assess intracellular glucose concentration in muscle, in vivo. The American Journal of Physiology. 274: E381-9. PMID 9486172 DOI: 10.1152/Ajpendo.1998.274.2.E381 |
0.426 |
|
| 1998 |
Laurent D, Petersen KF, Russell RR, Cline GW, Shulman GI. Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans American Journal of Physiology - Endocrinology and Metabolism. 274. PMID 9458758 DOI: 10.1152/Ajpendo.1998.274.1.E130 |
0.457 |
|
| 1998 |
Maggs DG, Buchanan TA, Burant CF, Cline G, Gumbiner B, Hsueh WA, Inzucchi S, Kelley D, Nolan J, Olefsky JM, Polonsky KS, Silver D, Valiquett TR, Shulman GI. Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial. Annals of Internal Medicine. 128: 176-85. PMID 9454525 DOI: 10.7326/0003-4819-128-3-199802010-00002 |
0.411 |
|
| 1997 |
Petersen KF, Jacob R, West AB, Sherwin RS, Shulman GI. Effects of insulin-like growth factor I on glucose metabolism in rats with liver cirrhosis. American Journal of Physiology. Endocrinology and Metabolism. 273: E1189-E1193. PMID 29585411 DOI: 10.1152/ajpendo.1997.273.6.E1189 |
0.371 |
|
| 1997 |
Petersen KF, Jacob R, West AB, Sherwin RS, Shulman GI. Effects of insulin-like growth factor I on glucose metabolism in rats with liver cirrhosis. The American Journal of Physiology. 273: E1189-93. PMID 9435535 DOI: 10.1152/Ajpendo.1997.273.6.E1189 |
0.533 |
|
| 1997 |
Russell RR, Cline GW, Guthrie PH, Goodwin GW, Shulman GI, Taegtmeyer H. Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart. A three tracer study of glycolysis, glycogen metabolism, and glucose oxidation Journal of Clinical Investigation. 100: 2892-2899. PMID 9389756 DOI: 10.1172/Jci119838 |
0.491 |
|
| 1997 |
Jucker BM, Rennings AJ, Cline GW, Petersen KF, Shulman GI. In vivo NMR investigation of intramuscular glucose metabolism in conscious rats. The American Journal of Physiology. 273: E139-48. PMID 9252490 DOI: 10.1152/Ajpendo.1997.273.1.E139 |
0.328 |
|
| 1997 |
Perseghin G, Ghosh S, Gerow K, Shulman GI. Metabolic defects in lean nondiabetic offspring of NIDDM parents: A cross-sectional study Diabetes. 46: 1001-1009. PMID 9166672 DOI: 10.2337/Diab.46.6.1001 |
0.475 |
|
| 1997 |
Cline GW, Magnusson I, Rothman DL, Petersen KF, Laurent D, Shulman GI. Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 99: 2219-24. PMID 9151794 DOI: 10.1172/Jci119395 |
0.477 |
|
| 1997 |
Jucker BM, Rennings AJ, Cline GW, Shulman GI. 13C and 31P NMR studies on the effects of increased plasma free fatty acids on intramuscular glucose metabolism in the awake rat. The Journal of Biological Chemistry. 272: 10464-73. PMID 9099689 DOI: 10.1074/Jbc.272.16.10464 |
0.419 |
|
| 1997 |
Young LH, Renfu Y, Russell R, Hu X, Caplan M, Ren J, Shulman GI, Sinusas AJ. Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation. 95: 415-22. PMID 9008459 DOI: 10.1161/01.Cir.95.2.415 |
0.361 |
|
| 1997 |
Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. The Journal of Clinical Investigation. 99: 361-5. PMID 9006005 DOI: 10.1172/Jci119165 |
0.405 |
|
| 1996 |
Sidossis LS, Stuart CA, Shulman GI, Lopaschuk GD, Wolfe RR. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. The Journal of Clinical Investigation. 98: 2244-50. PMID 8941640 DOI: 10.1172/Jci119034 |
0.476 |
|
| 1996 |
Jacob RJ, Dziura J, Morgen JP, Shulman GI, Sherwin RS. Time course of the defective alpha-cell response to hypoglycemia in diabetic BB rats. Metabolism: Clinical and Experimental. 45: 1422-6. PMID 8931649 DOI: 10.1016/S0026-0495(96)90125-0 |
0.386 |
|
| 1996 |
Velho G, Petersen KF, Perseghin G, Hwang JH, Rothman DL, Pueyo ME, Cline GW, Froguel P, Shulman GI. Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. The Journal of Clinical Investigation. 98: 1755-61. PMID 8878425 DOI: 10.1172/Jci118974 |
0.458 |
|
| 1996 |
Perseghin G, Price TB, Petersen KF, Roden M, Cline GW, Gerow K, Rothman DL, Shulman GI. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. The New England Journal of Medicine. 335: 1357-62. PMID 8857019 DOI: 10.1056/Nejm199610313351804 |
0.448 |
|
| 1996 |
Petersen KF, Price T, Cline GW, Rothman DL, Shulman GI. Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. The American Journal of Physiology. 270: E186-91. PMID 8772491 DOI: 10.1152/Ajpendo.1996.270.1.E186 |
0.451 |
|
| 1996 |
Petersen KF, West AB, Reuben A, Rothman DL, Shulman GI. Noninvasive assessment of hepatic triglyceride content in humans with 13C nuclear magnetic resonance spectroscopy. Hepatology (Baltimore, Md.). 24: 114-7. PMID 8707248 DOI: 10.1002/Hep.510240119 |
0.368 |
|
| 1996 |
McNulty PH, Sinusas AJ, Shi CQ, Dione D, Young LH, Cline GC, Shulman GI. Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia. The Journal of Clinical Investigation. 98: 62-9. PMID 8690805 DOI: 10.1172/Jci118778 |
0.412 |
|
| 1996 |
Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI. Mechanism of free fatty acid-induced insulin resistance in humans. The Journal of Clinical Investigation. 97: 2859-65. PMID 8675698 DOI: 10.1172/Jci118742 |
0.505 |
|
| 1996 |
Price TB, Perseghin G, Duleba A, Chen W, Chase J, Rothman DL, Shulman RG, Shulman GI. NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise. Proceedings of the National Academy of Sciences of the United States of America. 93: 5329-34. PMID 8643574 DOI: 10.1073/Pnas.93.11.5329 |
0.484 |
|
| 1996 |
Roden M, Perseghin G, Petersen KF, Hwang JH, Cline GW, Gerow K, Rothman DL, Shulman GI. The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. The Journal of Clinical Investigation. 97: 642-8. PMID 8609218 DOI: 10.1172/Jci118460 |
0.509 |
|
| 1996 |
Taylor R, Magnusson I, Rothman DL, Cline GW, Caumo A, Cobelli C, Shulman GI. Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. The Journal of Clinical Investigation. 97: 126-32. PMID 8550823 DOI: 10.1172/Jci118379 |
0.485 |
|
| 1995 |
Rothman DL, Magnusson I, Cline G, Gerard D, Kahn CR, Shulman RG, Shulman GI. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America. 92: 983-7. PMID 7862678 DOI: 10.1073/Pnas.92.4.983 |
0.503 |
|
| 1995 |
Hwang JH, Perseghin G, Rothman DL, Cline GW, Magnusson I, Petersen KF, Shulman GI. Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study. The Journal of Clinical Investigation. 95: 783-7. PMID 7860761 DOI: 10.1172/Jci117727 |
0.452 |
|
| 1995 |
Magnusson I, Rothman DL, Gerard DP, Katz LD, Shulman GI. Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration. Diabetes. 44: 185-9. PMID 7859939 DOI: 10.2337/Diab.44.2.185 |
0.433 |
|
| 1995 |
Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI. Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes. 44: 180-4. PMID 7859938 DOI: 10.2337/Diab.44.2.180 |
0.341 |
|
| 1995 |
Ren JM, Marshall BA, Mueckler MM, McCaleb M, Amatruda JM, Shulman GI. Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice. The Journal of Clinical Investigation. 95: 429-32. PMID 7814644 DOI: 10.1172/Jci117673 |
0.518 |
|
| 1995 |
Zawalich WS, Zawalich KC, Kelley GG, Shulman GI. Islet phosphoinositide hydrolysis and insulin secretory responses from prediabetic fa/fa ZDF rats Biochemical and Biophysical Research Communications. 209: 974-980. PMID 7733992 DOI: 10.1006/Bbrc.1995.1593 |
0.466 |
|
| 1995 |
Caprio S, Hyman LD, Limb C, McCarthy S, Lange R, Sherwin RS, Shulman G, Tamborlane WV. Central adiposity and its metabolic correlates in obese adolescent girls. The American Journal of Physiology. 269: E118-26. PMID 7631766 DOI: 10.1152/Ajpendo.1995.269.1.E118 |
0.495 |
|
| 1995 |
Cline GW, Shulman GI. Mass and positional isotopomer analysis of glucose metabolism in periportal and pericentral hepatocytes Journal of Biological Chemistry. 270: 28062-28067. PMID 7499292 DOI: 10.1074/Jbc.270.47.28062 |
0.366 |
|
| 1995 |
Petersen KF, Blair JB, Shulman GI. Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver Metabolism. 44: 1380-1383. PMID 7476321 DOI: 10.1016/0026-0495(95)90133-7 |
0.338 |
|
| 1994 |
Bloch G, Chase JR, Meyer DB, Avison MJ, Shulman GI, Shulman RG. In vivo regulation of rat muscle glycogen resynthesis after intense exercise. The American Journal of Physiology. 266: E85-91. PMID 8304447 DOI: 10.1152/Ajpendo.1994.266.1.E85 |
0.308 |
|
| 1994 |
Magnusson I, Rothman DL, Jucker B, Cline GW, Shulman RG, Shulman GI. Liver glycogen turnover in fed and fasted humans. The American Journal of Physiology. 266: E796-803. PMID 8203517 DOI: 10.1152/Ajpendo.1994.266.5.E796 |
0.427 |
|
| 1994 |
Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GI. Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. The Journal of Clinical Investigation. 93: 1677-82. PMID 8163668 DOI: 10.1172/Jci117150 |
0.333 |
|
| 1994 |
Petersen KF, Cline GW, Blair JB, Shulman GI. Substrate cycling between pyruvate and oxaloacetate in awake normal and 3,3'-5-triiodo-L-thyronine-treated rats American Journal of Physiology - Endocrinology and Metabolism. 267. PMID 8074207 DOI: 10.1152/Ajpendo.1994.267.2.E273 |
0.306 |
|
| 1994 |
Nelson T, Shulman G, Grainger D, Diamond MP. Progesterone administration induced impairment of insulin suppression of hepatic glucose production Fertility and Sterility. 62: 491-496. PMID 8062943 DOI: 10.1016/S0015-0282(16)56936-2 |
0.507 |
|
| 1994 |
Gruetter R, Magnusson I, Rothman DL, Avison MJ, Shulman RG, Shulman GI. Validation of 13C NMR measurements of liver glycogen in vivo. Magnetic Resonance in Medicine. 31: 583-8. PMID 8057810 DOI: 10.1002/Mrm.1910310602 |
0.305 |
|
| 1994 |
Caprio S, Cline G, Boulware S, Permanente C, Shulman GI, Sherwin RS, Tamborlane WV. Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. The American Journal of Physiology. 266: E885-91. PMID 8023918 DOI: 10.1152/Ajpendo.1994.266.6.E885 |
0.534 |
|
| 1994 |
Cline GW, Rothman DL, Magnusson I, Katz LD, Shulman GI. 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus. The Journal of Clinical Investigation. 94: 2369-76. PMID 7989593 DOI: 10.1172/Jci117602 |
0.531 |
|
| 1994 |
Price TB, Taylor R, Mason GF, Rothman DL, Shulman GI, Shulman RG. Turnover of human muscle glycogen with low-intensity exercise. Medicine and Science in Sports and Exercise. 26: 983-91. PMID 7968433 DOI: 10.1249/00005768-199408000-00009 |
0.304 |
|
| 1994 |
Price TB, Rothman DL, Taylor R, Avison MJ, Shulman GI, Shulman RG. Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases. Journal of Applied Physiology (Bethesda, Md. : 1985). 76: 104-11. PMID 7909795 DOI: 10.1152/Jappl.1994.76.1.104 |
0.441 |
|
| 1993 |
Zawalich WS, Zawalich KC, Cline G, Shulman G, Rasmussen H. Comparative effects of monomethylsuccinate and glucose on insulin secretion from perifused rat islets Diabetes. 42: 843-850. PMID 8388341 DOI: 10.2337/Diab.42.6.843 |
0.441 |
|
| 1993 |
Rossi G, Lapaczewski P, Diamond MP, Jacob RJ, Shulman GI, Sherwin RS. Inhibitory effect of pregnancy on counterregulatory hormone responses to hypoglycemia in awake rat. Diabetes. 42: 1440-5. PMID 8375583 DOI: 10.2337/Diab.42.10.1440 |
0.398 |
|
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