Besim Ogretmen - Publications

Affiliations: 
Medical University of South Carolina, Charleston, SC, United States 
Area:
Molecular Biology, Biochemistry

99 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sofi MH, Wu Y, Schutt SD, Dai M, Daenthanasanmak A, Heinrichs Voss J, Nguyen H, Bastian D, Iamsawat S, Selvam SP, Liu C, Maulik N, Ogretmen B, Jin J, Mehrotra S, et al. Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease. The Journal of Clinical Investigation. 130. PMID 31045571 DOI: 10.1172/JCI122899  0.6
2019 Chakraborty P, Chatterjee S, Kesarwani P, Thyagarajan K, Iamsawat S, Dalheim A, Nguyen H, Selvam SP, Nasarre P, Scurti G, Hardiman G, Maulik N, Ball LE, Gangaraju V, Rubinstein MP, ... ... Ogretmen B, et al. Thioredoxin-1 improves the immuno-metabolic phenotype of anti-tumor T cells. The Journal of Biological Chemistry. PMID 30971427 DOI: 10.1074/jbc.RA118.006753  0.6
2019 De Palma RM, Parnham SR, Li Y, Oaks JJ, Peterson YK, Szulc ZM, Roth BM, Xing Y, Ogretmen B. The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802264R. PMID 30917007 DOI: 10.1096/fj.201802264R  0.44
2019 Qie S, Yoshida A, Parnham S, Oleinik N, Beeson GC, Beeson CC, Ogretmen B, Bass AJ, Wong KK, Rustgi AK, Diehl JA. Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma. Nature Communications. 10: 1296. PMID 30899002 DOI: 10.1038/s41467-019-09179-w  0.6
2018 Nguyen H, Kuril S, Bastian D, Kim J, Zhang M, Vaena SG, Dany M, Dai M, Heinrichs JL, Daenthanasanmak A, Iamsawat S, Schutt S, Fu J, Wu Y, Fairlie DP, ... ... Ogretmen B, et al. Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells. Jci Insight. 3. PMID 30568037 DOI: 10.1172/jci.insight.121697  0.4
2018 Nganga R, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Johnson KA, Parikh RY, Gangaraju V, Peterson Y, Dany M, Stahelin RV, Voelkel-Johnson C, Szulc ZM, Bieberich E, Ogretmen B. Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis. The Journal of Biological Chemistry. PMID 30420430 DOI: 10.1074/jbc.RA118.005865  0.6
2018 Nganga R, Oleinik N, Ogretmen B. Mechanisms of Ceramide-Dependent Cancer Cell Death. Advances in Cancer Research. 140: 1-25. PMID 30060806 DOI: 10.1016/bs.acr.2018.04.007  0.6
2018 Panneer Selvam S, Roth BM, Nganga R, Kim J, Cooley MA, Helke KL, Smith CD, Ogretmen B. Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3. The Journal of Biological Chemistry. PMID 29748384 DOI: 10.1074/jbc.RA118.003506  0.6
2017 Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, ... ... Ogretmen B, et al. CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metabolism. PMID 29129787 DOI: 10.1016/j.cmet.2017.10.006  0.6
2017 Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, Nganga R, Thomas RJ, Senkal CE, Howe PH, Ogretmen B. TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Science Signaling. 10. PMID 29066540 DOI: 10.1126/scisignal.aam7464  0.6
2017 Thomas RJ, Oleinik N, Panneer Selvam S, Vaena SG, Dany M, Nganga RN, Depalma R, Baron KD, Kim J, Szulc ZM, Ogretmen B. HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. Embo Molecular Medicine. PMID 28606997 DOI: 10.15252/emmm.201607088  0.6
2017 Sofi MH, Heinrichs J, Dany M, Nguyen H, Dai M, Bastian D, Schutt S, Wu Y, Daenthanasanmak A, Gencer S, Zivkovic A, Szulc Z, Stark H, Liu C, Chang YJ, ... Ogretmen B, et al. Ceramide synthesis regulates T cell activity and GVHD development. Jci Insight. 2. PMID 28515365 DOI: 10.1172/jci.insight.91701  0.32
2017 Britten CD, Thomas MB, Garrett-Mayer E, Chin SH, Shirai K, Ogretmen B, Bentz TA, Brisendine A, Anderton K, Cusack SL, Maines LW, Zhuang Y, Smith CD. A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28420720 DOI: 10.1158/1078-0432.CCR-16-2363  0.44
2017 Lv Z, Rickman KA, Yuan L, Williams K, Selvam SP, Woosley AN, Howe PH, Ogretmen B, Smogorzewska A, Olsen SK. S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. Molecular Cell. PMID 28162934 DOI: 10.1016/j.molcel.2017.01.008  0.6
2016 Dany M, Gencer S, Nganga R, Thomas RJ, Oleinik N, Baron KD, Szulc ZM, Ruvolo P, Kornblau S, Andreeff M, Ogretmen B. Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML. Blood. PMID 27540013 DOI: 10.1182/blood-2016-04-708750  0.6
2015 Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Science Signaling. 8: ra58. PMID 26082434 DOI: 10.1126/scisignal.aaa4998  0.84
2015 Karlsson I, Zhou X, Thomas R, Smith AT, Bonner MY, Bakshi P, Banga AK, Bowen JP, Qabaja G, Ford SL, Ballard MD, Petersen KS, Li X, Chen G, Ogretmen B, et al. Solenopsin A and analogs exhibit ceramide-like biological activity. Vascular Cell. 7: 5. PMID 26015865 DOI: 10.1186/s13221-015-0030-2  0.84
2015 Tirodkar TS, Lu P, Bai A, Scheffel MJ, Gencer S, Garrett-Mayer E, Bielawska A, Ogretmen B, Voelkel-Johnson C. Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. The Journal of Biological Chemistry. 290: 13157-67. PMID 25839235 DOI: 10.1074/jbc.M114.631325  0.84
2015 Dany M, Ogretmen B. Ceramide induced mitophagy and tumor suppression. Biochimica Et Biophysica Acta. 1853: 2834-45. PMID 25634657 DOI: 10.1016/j.bbamcr.2014.12.039  0.84
2015 Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z. Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. Journal of Hepatology. 62: 879-88. PMID 25463537 DOI: 10.1016/j.jhep.2014.11.010  0.84
2014 Venkata JK, An N, Stuart R, Costa LJ, Cai H, Coker W, Song JH, Gibbs K, Matson T, Garrett-Mayer E, Wan Z, Ogretmen B, Smith C, Kang Y. Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. Blood. 124: 1915-25. PMID 25122609 DOI: 10.1182/blood-2014-03-559385  0.84
2014 Dai L, Plaisance-Bonstaff K, Voelkel-Johnson C, Smith CD, Ogretmen B, Qin Z, Parsons C. Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells. Plos One. 9: e102314. PMID 25010828 DOI: 10.1371/journal.pone.0102314  0.84
2014 Qin Z, Dai L, Trillo-Tinoco J, Senkal C, Wang W, Reske T, Bonstaff K, Del Valle L, Rodriguez P, Flemington E, Voelkel-Johnson C, Smith CD, Ogretmen B, Parsons C. Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Molecular Cancer Therapeutics. 13: 154-64. PMID 24140934 DOI: 10.1158/1535-7163.MCT-13-0466  0.84
2014 Jiang W, Ogretmen B. Autophagy paradox and ceramide. Biochimica Et Biophysica Acta. 1841: 783-92. PMID 24055889 DOI: 10.1016/j.bbalip.2013.09.005  0.84
2013 Hamed HA, Das SK, Sokhi UK, Park MA, Cruickshanks N, Archer K, Ogretmen B, Grant S, Sarkar D, Fisher PB, Dent P. Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells. Cancer Biology & Therapy. 14: 1039-49. PMID 24025359 DOI: 10.4161/cbt.26110  0.84
2013 Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, ... ... Ogretmen B, et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. The Journal of Clinical Investigation. 123: 4144-57. PMID 23999433 DOI: 10.1172/JCI68951  0.84
2013 Oaks JJ, Santhanam R, Walker CJ, Roof S, Harb JG, Ferenchak G, Eisfeld AK, Van Brocklyn JR, Briesewitz R, Saddoughi SA, Nagata K, Bittman R, Caligiuri MA, Abdel-Wahab O, Levine R, ... ... Ogretmen B, et al. Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood. 122: 1923-34. PMID 23926298 DOI: 10.1182/blood-2013-03-492181  0.84
2013 Alberg AJ, Armeson K, Pierce JS, Bielawski J, Bielawska A, Visvanathan K, Hill EG, Ogretmen B. Plasma sphingolipids and lung cancer: a population-based, nested case-control study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 22: 1374-82. PMID 23749868 DOI: 10.1158/1055-9965.EPI-12-1424  0.84
2013 Selvam SP, Ogretmen B. Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance. Handbook of Experimental Pharmacology. 3-27. PMID 23563649 DOI: 10.1007/978-3-7091-1511-4_1  0.84
2013 Saddoughi SA, Ogretmen B. Diverse functions of ceramide in cancer cell death and proliferation. Advances in Cancer Research. 117: 37-58. PMID 23290776 DOI: 10.1016/B978-0-12-394274-6.00002-9  0.84
2013 Jiang W, Ogretmen B. Ceramide stress in survival versus lethal autophagy paradox: ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Autophagy. 9: 258-9. PMID 23182807 DOI: 10.4161/auto.22739  0.84
2013 Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, ... ... Ogretmen B, et al. Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. Embo Molecular Medicine. 5: 105-21. PMID 23180565 DOI: 10.1002/emmm.201201283  0.84
2013 Beckham TH, Lu P, Jones EE, Marrison T, Lewis CS, Cheng JC, Ramshesh VK, Beeson G, Beeson CC, Drake RR, Bielawska A, Bielawski J, Szulc ZM, Ogretmen B, Norris JS, et al. LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria. The Journal of Pharmacology and Experimental Therapeutics. 344: 167-78. PMID 23086228 DOI: 10.1124/jpet.112.199216  0.84
2012 Syed I, Szulc ZM, Ogretmen B, Kowluru A. L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 30: 1051-8. PMID 23052231 DOI: 10.1159/000341481  0.84
2012 Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nature Chemical Biology. 8: 831-8. PMID 22922758 DOI: 10.1038/nchembio.1059  0.84
2012 Ponnusamy S, Selvam SP, Mehrotra S, Kawamori T, Snider AJ, Obeid LM, Shao Y, Sabbadini R, Ogretmen B. Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. Embo Molecular Medicine. 4: 761-75. PMID 22707406 DOI: 10.1002/emmm.201200244  0.84
2012 Bareford MD, Hamed HA, Allegood J, Cruickshanks N, Poklepovic A, Park MA, Ogretmen B, Spiegel S, Grant S, Dent P. Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling. Cancer Biology & Therapy. 13: 793-803. PMID 22673740 DOI: 10.4161/cbt.20562  0.84
2012 Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Molecular Cancer Therapeutics. 11: 1092-102. PMID 22452947 DOI: 10.1158/1535-7163.MCT-11-0705  0.84
2012 Booth L, Cazanave SC, Hamed HA, Yacoub A, Ogretmen B, Chen CS, Grant S, Dent P. OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing. Cancer Biology & Therapy. 13: 224-36. PMID 22354011 DOI: 10.4161/cbt.13.4.18877  0.84
2012 Meyers-Needham M, Ponnusamy S, Gencer S, Jiang W, Thomas RJ, Senkal CE, Ogretmen B. Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells. Embo Molecular Medicine. 4: 78-92. PMID 22180294 DOI: 10.1002/emmm.201100189  0.84
2011 Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. The Journal of Biological Chemistry. 286: 42446-58. PMID 22013072 DOI: 10.1074/jbc.M111.287383  0.84
2011 Baran Y, Bielawski J, Gunduz U, Ogretmen B. Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation. Journal of Cancer Research and Clinical Oncology. 137: 1535-44. PMID 21833718 DOI: 10.1007/s00432-011-1016-y  0.84
2011 Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, ... Ogretmen B, et al. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C₁₈-ceramide as a novel biomarker for monitoring response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6097-105. PMID 21791630 DOI: 10.1158/1078-0432.CCR-11-0930  0.84
2011 Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, ... ... Ogretmen B, et al. Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 117: 5941-52. PMID 21527515 DOI: 10.1182/blood-2010-08-300772  0.84
2011 Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T. A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.). 4: 454-62. PMID 21209394 DOI: 10.1158/1940-6207.CAPR-10-0299  0.84
2011 Separovic D, Bielawski J, Pierce JS, Merchant S, Tarca AL, Bhatti G, Ogretmen B, Korbelik M. Enhanced tumor cures after Foscan photodynamic therapy combined with the ceramide analog LCL29. Evidence from mouse squamous cell carcinomas for sphingolipids as biomarkers of treatment response International Journal of Oncology. 38: 521-527. PMID 21152858 DOI: 10.3892/ijo.2010.863  0.84
2011 Park MA, Hamed HA, Mitchell C, Cruickshanks N, Dash R, Allegood J, Dmitriev IP, Tye G, Ogretmen B, Spiegel S, Yacoub A, Grant S, Curiel DT, Fisher PB, Dent P. A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels. Molecular Pharmacology. 79: 368-80. PMID 21119025 DOI: 10.1124/mol.110.069484  0.84
2010 Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A, Ogretmen B. Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncology (London, England). 6: 1603-24. PMID 21062159 DOI: 10.2217/fon.10.116  0.84
2010 Park MA, Reinehr R, Häussinger D, Voelkel-Johnson C, Ogretmen B, Yacoub A, Grant S, Dent P. Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells. Molecular Cancer Therapeutics. 9: 2220-31. PMID 20682655 DOI: 10.1158/1535-7163.MCT-10-0274  0.84
2010 Park MA, Mitchell C, Zhang G, Yacoub A, Allegood J, Häussinger D, Reinehr R, Larner A, Spiegel S, Fisher PB, Voelkel-Johnson C, Ogretmen B, Grant S, Dent P. Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Research. 70: 6313-24. PMID 20631069 DOI: 10.1158/0008-5472.CAN-10-0999  0.84
2010 Yacoub A, Hamed HA, Allegood J, Mitchell C, Spiegel S, Lesniak MS, Ogretmen B, Dash R, Sarkar D, Broaddus WC, Grant S, Curiel DT, Fisher PB, Dent P. PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Cancer Research. 70: 1120-9. PMID 20103619 DOI: 10.1158/0008-5472.CAN-09-4043  0.84
2010 Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B. Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 296-308. PMID 19723703 DOI: 10.1096/fj.09-135087  0.84
2009 Demarse NA, Ponnusamy S, Spicer EK, Apohan E, Baatz JE, Ogretmen B, Davies C. Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation. Journal of Molecular Biology. 394: 789-803. PMID 19800890 DOI: 10.1016/j.jmb.2009.09.062  0.84
2009 Patwardhan GA, Zhang QJ, Yin D, Gupta V, Bao J, Senkal CE, Ogretmen B, Cabot MC, Shah GV, Sylvester PW, Jazwinski SM, Liu YY. A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. Plos One. 4: e6938. PMID 19742320 DOI: 10.1371/journal.pone.0006938  0.84
2009 Separovic D, Bielawski J, Pierce JS, Merchant S, Tarca AL, Ogretmen B, Korbelik M. Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas British Journal of Cancer. 100: 626-632. PMID 19223911 DOI: 10.1038/sj.bjc.6604896  0.84
2009 White-Gilbertson S, Mullen T, Senkal C, Lu P, Ogretmen B, Obeid L, Voelkel-Johnson C. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells Oncogene. 28: 1132-1141. PMID 19137010 DOI: 10.1038/onc.2008.468  0.84
2009 Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B. Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 751-63. PMID 19028839 DOI: 10.1096/fj.08-120550  0.84
2008 Saddoughi SA, Song P, Ogretmen B. Roles of bioactive sphingolipids in cancer biology and therapeutics. Sub-Cellular Biochemistry. 49: 413-40. PMID 18751921 DOI: 10.1007/978-1-4020-8831-5_16  0.84
2008 Ponnusamy S, Alderson NL, Hama H, Bielawski J, Jiang JC, Bhandari R, Snyder SH, Jazwinski SM, Ogretmen B. Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function. The Journal of Biological Chemistry. 283: 27514-24. PMID 18694931 DOI: 10.1074/jbc.M802980200  0.84
2008 Corcoran CA, He Q, Ponnusamy S, Ogretmen B, Huang Y, Sheikh MS. Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies. Molecular Cancer Research : McR. 6: 795-807. PMID 18505924 DOI: 10.1158/1541-7786.MCR-07-2097  0.84
2007 Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, Ogretmen B. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Letters. 256: 101-11. PMID 17619081 DOI: 10.1016/j.canlet.2007.06.003  0.84
2007 Wooten-Blanks LG, Song P, Senkal CE, Ogretmen B. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3386-97. PMID 17548428 DOI: 10.1096/fj.07-8621com  0.84
2007 Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B. Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Molecular Cancer Therapeutics. 6: 712-22. PMID 17308067 DOI: 10.1158/1535-7163.MCT-06-0558  0.84
2007 Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM, Ogretmen B. Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. The Journal of Biological Chemistry. 282: 10922-34. PMID 17303574 DOI: 10.1074/jbc.M610157200  0.84
2007 Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A. Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. The Journal of Biological Chemistry. 282: 16718-28. PMID 17283068 DOI: 10.1074/jbc.M700647200  0.84
2006 Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA. Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. The Journal of Biological Chemistry. 281: 36793-802. PMID 17030510 DOI: 10.1074/jbc.M608137200  0.84
2006 Ogretmen B. Sphingolipids in cancer: regulation of pathogenesis and therapy. Febs Letters. 580: 5467-76. PMID 16970943 DOI: 10.1016/j.febslet.2006.08.052  0.84
2006 Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 317: 1188-99. PMID 16510697 DOI: 10.1124/jpet.106.101949  0.84
2006 Sultan I, Senkal CE, Ponnusamy S, Bielawski J, Szulc Z, Bielawska A, Hannun YA, Ogretmen B. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. The Biochemical Journal. 393: 513-21. PMID 16201965 DOI: 10.1042/BJ20051083  0.84
2005 Wooten LG, Ogretmen B. Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. The Journal of Biological Chemistry. 280: 28867-76. PMID 15951564 DOI: 10.1074/jbc.M413444200  0.84
2005 Johnson KR, Johnson KY, Crellin HG, Ogretmen B, Boylan AM, Harley RA, Obeid LM. Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1159-66. PMID 15923363 DOI: 10.1369/jhc.4A6606.2005  0.84
2005 Rossi MJ, Sundararaj K, Koybasi S, Phillips MS, Szulc ZM, Bielawska A, Day TA, Obeid LM, Hannun YA, Ogretmen B. Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 132: 55-62. PMID 15632910 DOI: 10.1016/j.otohns.2004.08.015  0.84
2004 Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas Journal of Biological Chemistry. 279: 44311-44319. PMID 15317812 DOI: 10.1074/jbc.M406920200  0.84
2004 Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nature Reviews. Cancer. 4: 604-16. PMID 15286740 DOI: 10.1038/nrc1411  0.84
2004 Day TA, Deveikis J, Gillespie MB, Joe JK, Ogretmen B, Osguthorpe JD, Reed SG, Richardson MS, Rossi M, Saini R, Sharma AK, Stuart RK. Salivary gland neoplasms. Current Treatment Options in Oncology. 5: 11-26. PMID 14697153  0.84
2004 Sundararaj KP, Wood RE, Ponnusamy S, Salas AM, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Ogretmen B. Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. The Journal of Biological Chemistry. 279: 6152-62. PMID 14630908 DOI: 10.1074/jbc.M310549200  0.84
2003 Kraveka JM, Li L, Bielawski J, Obeid LM, Ogretmen B. Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells. Archives of Biochemistry and Biophysics. 419: 110-9. PMID 14592454 DOI: 10.1016/j.abb.2003.08.034  0.84
2002 Wu CH, Gordon J, Rastegar M, Ogretmen B, Safa AR. Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant. Oncogene. 21: 5160-74. PMID 12140766 DOI: 10.1038/sj.onc.1205639  0.84
2002 Ogretmen B, Pettus BJ, Rossi MJ, Wood R, Usta J, Szulc Z, Bielawska A, Obeid LM, Hannun YA. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. The Journal of Biological Chemistry. 277: 12960-9. PMID 11815611 DOI: 10.1074/jbc.M110699200  0.84
2002 Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, Hannun YA. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. The Journal of Biological Chemistry. 277: 12587-95. PMID 11801602 DOI: 10.1074/jbc.M112010200  0.84
2001 Ogretmen B, Hannun YA. Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance Drug Resistance Updates. 4: 368-377. PMID 12030784 DOI: 10.1054/drup.2001.0225  0.84
2001 Chalfant CE, Ogretmen B, Galadari S, Kroesen BJ, Pettus BJ, Hannun YA. FAS Activation Induces Dephosphorylation of SR Proteins: Dependence on the de novo generation of ceramide and activation of protein phosphatase 1 Journal of Biological Chemistry. 276: 44848-44855. PMID 11502750 DOI: 10.1074/jbc.M106291200  0.84
2001 Boujaoude LC, Bradshaw-Wilder C, Mao C, Cohn J, Ogretmen B, Hannun YA, Obeid LM. Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: Modulation of cellular activity of sphingosine 1-phosphate Journal of Biological Chemistry. 276: 35258-35264. PMID 11443135 DOI: 10.1074/jbc.M105442200  0.84
2001 Ogretmen B, Kraveka JM, Schady D, Usta J, Hannun YA, Obeid LM. Molecular Mechanisms of Ceramide-mediated Telomerase Inhibition in the A549 Human Lung Adenocarcinoma Cell Line Journal of Biological Chemistry. 276: 32506-32514. PMID 11441001 DOI: 10.1074/jbc.M101350200  0.84
2001 Ogretmen B, Schady D, Usta J, Wood R, Kraveka JM, Luberto C, Birbes H, Hannun YA, Obeid LM. Role of Ceramide in Mediating the Inhibition of Telomerase Activity in A549 Human Lung Adenocarcinoma Cells Journal of Biological Chemistry. 276: 24901-24910. PMID 11335714 DOI: 10.1074/jbc.M100314200  0.84
2001 Kraveka JM, Schady D, Obeid LM, Ogretmen B. Immunoprecipitation of human telomerase reverse transcriptase with telomerase activity Analytical Biochemistry. 291: 166-169. PMID 11262172 DOI: 10.1006/abio.2001.5033  0.84
2000 Ogretmen B, Barredo JC, Safa AR. Increased expression of lung resistance-related protein and multidrug resistance-associated protein messenger RNA in childhood acute lymphoblastic leukemia Journal of Pediatric Hematology/Oncology. 22: 45-49. PMID 10695821 DOI: 10.1097/00043426-200001000-00009  0.84
2000 Ogretmen B, Safa AR. Identification and characterization of the MDR1 promoter-enhancing factor 1 (MEF1) in the multidrug resistant HL60/VCR human acute myeloid leukemia cell line Biochemistry. 39: 194-204. PMID 10625494 DOI: 10.1021/bi991943f  0.84
1999 Ogretmen B, Safa AR. Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-κb/p65 and c-Fos transcription factors and their interaction with the CAAT region Biochemistry. 38: 2189-2199. PMID 10026303 DOI: 10.1021/bi982236+  0.84
1998 Ogretmen B, Bahadori H, McCauley M, Boylan A, Green M, Safa AR. Lack of correlation of MRP and γ-glutamylcysteine synthetase overexpression with doxorubicin resistance due to increased apoptosis in SV40 large T-antigen-transformed human mesothelial cells Cancer Chemotherapy and Pharmacology. 42: 441-446. PMID 9788569 DOI: 10.1007/s002800050843  0.84
1998 Ogretmen B, McCauley MD, Safa AR. Molecular mechanisms of loss of β2-microglobulin expression in drug- resistant breast cancer sublines and its involvement in drug resistance Biochemistry. 37: 11679-11691. PMID 9709006 DOI: 10.1021/bi980573c  0.84
1998 Ogretmen B, Bahadori HR, Mccauley MD, Boylan A, Green MR, Safa AR. Co-ordinated over-expression of the MRP and γ-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines International Journal of Cancer. 75: 757-761. PMID 9495245 DOI: 10.1002/(SICI)1097-0215(19980302)75:5<757::AID-IJC15>3.0.CO;2-3  0.84
1997 Ogretmen B, Safa AR. Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells Oncogene. 14: 499-506. PMID 9053847  0.84
1996 Ogretmen B, Carpo C, Safa AR. Site-directed mutagenesis by unique site elimination using filamentous phage-derived ssDNA templates for plasmids that are resistant to denaturation Biotechniques. 21: 209-213. PMID 8862800  0.84
1996 Ogretmen B, Safa AR. Down-regulation of apoptosis-related bcl-2 but not bcl-x(L) or bax proteins in multidrug-resistant MCF-7/Adr human breast cancer cells International Journal of Cancer. 67: 608-614. PMID 8782646 DOI: 10.1002/(SICI)1097-0215(19960904)67:5<608::AID-IJC3>3.0.CO;2-Y  0.84
1996 Ogretmen B, Ratajczak H, Gendel SM, Stark BC. Effects of sodium saccharin and linoleic acid on mRNA levels of Her2/neu and p53 in a human breast epithelial cell line Cancer Letters. 102: 91-99. PMID 8603385 DOI: 10.1016/0304-3835(96)04170-5  0.84
1995 Ogretmen B, Safa AR. Mini-preparation of total RNA for RT-PCR from cultured human cells Biotechniques. 19: 374-375+377. PMID 7495548  0.84
1993 Ogretmen B, Ratajczak H, Kats A, Stark BC, Gendel SM. Effects of staining of RNA with ethidium bromide before electrophoresis on performance of Northern blots Biotechniques. 14: 936-939.  0.84
1992 Liu SC, Ogretmen B, Chuang YY, Stark BC. Selection and characterization of alpha-amylase-overproducing recombinant Escherichia coli containing the bacterial hemoglobin gene. Applied Microbiology and Biotechnology. 38: 239-42. PMID 1369145 DOI: 10.1007/BF00174475  0.84
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