Jurgen Rohr - Publications

Affiliations: 
Pharmaceutical Sciences University of Kentucky, Lexington, KY 
Area:
Pharmacy, Biochemistry

113 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Cui Z, Wang XC, Liu X, Lemke A, Koppermann S, Ducho C, Rohr J, Thorson JS, Van Lanen SG. Self-Resistance During Muraymycin Biosynthesis: A Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order. Antimicrobial Agents and Chemotherapy. PMID 29735559 DOI: 10.1128/AAC.00193-18  0.52
2017 Wang X, Elshahawi SI, Cai W, Zhang Y, Ponomareva LV, Chen X, Copley GC, Hower JC, Zhan CG, Parkin S, Rohr J, Van Lanen SG, Shaaban KA, Thorson JS. Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2. Journal of Natural Products. PMID 28358212 DOI: 10.1021/acs.jnatprod.7b00108  0.52
2017 Panchuk RR, Lehka LV, Terenzi A, Matselyukh BP, Rohr J, Jha AK, Downey T, Kril' IJ, Herbacek I, van Schonhoven S, Heffeter P, Stoika RS, Berger W. Rapid generation of hydrogen peroxide contributes to the complex cell death induction by the angucycline antibiotic landomycin E. Free Radical Biology & Medicine. PMID 28189848 DOI: 10.1016/j.freeradbiomed.2017.02.024  0.32
2017 Goswami A, Liu X, Cai W, Wyche TP, Bugni TS, Meurillon M, Peyrottes S, Perigaud C, Nonaka K, Rohr J, Van Lanen SG. Evidence that Oxidative Dephosphorylation by the Non-heme Fe(II), α-Ketoglutarate:UMP Oxygenase Occurs by Stereospecific Hydroxylation. Febs Letters. PMID 28074470 DOI: 10.1002/1873-3468.12554  0.52
2016 Blundell RD, Williams SJ, Arras SD, Chitty JL, Blake KL, Ericsson DJ, Tibrewal N, Rohr J, Koh YQ, Kappler U, Robertson AA, Butler MS, Cooper MA, Kobe B, Fraser JA. Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans. Acs Infectious Diseases. 2: 651-663. PMID 27759389 DOI: 10.1021/acsinfecdis.6b00121  0.52
2016 Jackson D, Yu X, Wang G, Patel A, Barajas J, Sasaki E, Metsa-Ketala M, Liu HW, Rohr J, Tsai SS. Insights Into Complex Oxidation During BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE. Acs Chemical Biology. PMID 26813028 DOI: 10.1021/acschembio.5b00913  0.52
2015 Weidenbach S, Hou C, Chen JM, Tsodikov OV, Rohr J. Dimerization and DNA recognition rules of mithramycin and its analogues. Journal of Inorganic Biochemistry. 156: 40-47. PMID 26760230 DOI: 10.1016/j.jinorgbio.2015.12.011  0.52
2015 Lassak J, Keilhauer EC, Fürst M, Wuichet K, Gödeke J, Starosta AL, Chen JM, Søgaard-Andersen L, Rohr J, Wilson DN, Häussler S, Mann M, Jung K. Arginine-rhamnosylation as new strategy to activate translation elongation factor P. Nature Chemical Biology. 11: 266-70. PMID 25686373 DOI: 10.1038/nchembio.1751  0.52
2015 Chen JM, Hou C, Wang G, Tsodikov OV, Rohr J. Structural insight into MtmC, a bifunctional ketoreductase-methyltransferase involved in the assembly of the mithramycin trisaccharide chain. Biochemistry. 54: 2481-9. PMID 25587924 DOI: 10.1021/bi501462g  0.52
2015 Savi DC, Shaaban KA, Vargas N, Ponomareva LV, Possiede YM, Thorson JS, Glienke C, Rohr J. Microbispora sp. LGMB259 endophytic actinomycete isolated from Vochysia divergens (Pantanal, Brazil) producing β-carbolines and indoles with biological activity. Current Microbiology. 70: 345-54. PMID 25385358 DOI: 10.1007/s00284-014-0724-3  0.52
2014 Chen JM, Shepherd MD, Horn J, Leggas M, Rohr J. Enzymatic methylation and structure-activity-relationship studies on polycarcin V, a gilvocarcin-type antitumor agent. Chembiochem : a European Journal of Chemical Biology. 15: 2729-35. PMID 25366963 DOI: 10.1002/cbic.201402426  0.52
2014 Singh S, Zhang J, Huber TD, Sunkara M, Hurley K, Goff RD, Wang G, Zhang W, Liu C, Rohr J, Van Lanen SG, Morris AJ, Thorson JS. Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues. Angewandte Chemie (International Ed. in English). 53: 3965-9. PMID 24616228 DOI: 10.1002/anie.201308272  0.52
2013 Bosserman MA, Downey T, Noinaj N, Buchanan SK, Rohr J. Molecular insight into substrate recognition and catalysis of Baeyer-Villiger monooxygenase MtmOIV, the key frame-modifying enzyme in the biosynthesis of anticancer agent mithramycin. Acs Chemical Biology. 8: 2466-77. PMID 23992662 DOI: 10.1021/cb400399b  0.52
2013 Garcia I, Vior NM, González-Sabín J, Braña AF, Rohr J, Moris F, Méndez C, Salas JA. Engineering the biosynthesis of the polyketide-nonribosomal peptide collismycin A for generation of analogs with neuroprotective activity. Chemistry & Biology. 20: 1022-32. PMID 23911584 DOI: 10.1016/j.chembiol.2013.06.014  0.44
2013 Shamaladevi N, Lyn DA, Shaaban KA, Zhang L, Villate S, Rohr J, Lokeshwar BL. Ericifolin: a novel antitumor compound from allspice that silences androgen receptor in prostate cancer. Carcinogenesis. 34: 1822-32. PMID 23568956 DOI: 10.1093/carcin/bgt123  0.52
2013 Scott D, Chen JM, Bae Y, Rohr J. Semi-synthetic mithramycin SA derivatives with improved anticancer activity. Chemical Biology & Drug Design. 81: 615-24. PMID 23331575 DOI: 10.1111/cbdd.12107  0.52
2012 Barnard-Britson S, Chi X, Nonaka K, Spork AP, Tibrewal N, Goswami A, Pahari P, Ducho C, Rohr J, Van Lanen SG. Amalgamation of nucleosides and amino acids in antibiotic biosynthesis: discovery of an L-threonine:uridine-5'-aldehyde transaldolase. Journal of the American Chemical Society. 134: 18514-7. PMID 23110675 DOI: 10.1021/ja308185q  0.52
2012 Tibrewal N, Pahari P, Wang G, Kharel MK, Morris C, Downey T, Hou Y, Bugni TS, Rohr J. Baeyer-Villiger C-C bond cleavage reaction in gilvocarcin and jadomycin biosynthesis. Journal of the American Chemical Society. 134: 18181-4. PMID 23102024 DOI: 10.1021/ja3081154  0.52
2012 Shaaban KA, Shepherd MD, Ahmed TA, Nybo SE, Leggas M, Rohr J. Pyramidamycins A-D and 3-hydroxyquinoline-2-carboxamide; cytotoxic benzamides from Streptomyces sp. DGC1. The Journal of Antibiotics. 65: 615-22. PMID 23047245 DOI: 10.1038/ja.2012.81  0.52
2012 Wang G, Pahari P, Kharel MK, Chen J, Zhu H, Van Lanen SG, Rohr J. Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin. Angewandte Chemie (International Ed. in English). 51: 10638-42. PMID 22997042 DOI: 10.1002/anie.201205414  0.52
2012 Tibrewal N, Downey TE, Van Lanen SG, Ul Sharif E, O'Doherty GA, Rohr J. Roles of the synergistic reductive O-methyltransferase GilM and of O-methyltransferase GilMT in the gilvocarcin biosynthetic pathway. Journal of the American Chemical Society. 134: 12402-5. PMID 22800463 DOI: 10.1021/ja305113d  0.52
2012 Shaaban KA, Ahmed TA, Leggas M, Rohr J. Saquayamycins G-K, cytotoxic angucyclines from Streptomyces sp. Including two analogues bearing the aminosugar rednose. Journal of Natural Products. 75: 1383-92. PMID 22758660 DOI: 10.1021/np300316b  0.52
2012 Patrikainen P, Kallio P, Fan K, Klika KD, Shaaban KA, Mäntsälä P, Rohr J, Yang K, Niemi J, Metsä-Ketelä M. Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities. Chemistry & Biology. 19: 647-55. PMID 22633416 DOI: 10.1016/j.chembiol.2012.04.010  0.52
2012 Núñez LE, Nybo SE, González-Sabín J, Pérez M, Menéndez N, Braña AF, Shaaban KA, He M, Morís F, Salas JA, Rohr J, Méndez C. A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis. Journal of Medicinal Chemistry. 55: 5813-25. PMID 22578073 DOI: 10.1021/jm300234t  0.52
2012 Kharel MK, Rohr J. Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology. Current Opinion in Chemical Biology. 16: 150-61. PMID 22465094 DOI: 10.1016/j.cbpa.2012.03.007  0.52
2012 Kharel MK, Pahari P, Shaaban KA, Wang G, Morris C, Rohr J. Elucidation of post-PKS tailoring steps involved in landomycin biosynthesis. Organic & Biomolecular Chemistry. 10: 4256-65. PMID 22454092 DOI: 10.1039/c2ob07171a  0.44
2012 Garcia I, Vior NM, Braña AF, González-Sabin J, Rohr J, Moris F, Méndez C, Salas JA. Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: mechanism for formation of the 2,2'-bipyridyl ring. Chemistry & Biology. 19: 399-413. PMID 22444595 DOI: 10.1016/j.chembiol.2012.01.014  0.44
2012 Nybo SE, Shabaan KA, Kharel MK, Sutardjo H, Salas JA, Méndez C, Rohr J. Ketoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGT. Bioorganic & Medicinal Chemistry Letters. 22: 2247-50. PMID 22361136 DOI: 10.1016/j.bmcl.2012.01.094  0.44
2012 Pahari P, Kharel MK, Shepherd MD, van Lanen SG, Rohr J. Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis. Angewandte Chemie (International Ed. in English). 51: 1216-20. PMID 22223167 DOI: 10.1002/anie.201105882  0.52
2012 Kharel MK, Pahari P, Shepherd MD, Tibrewal N, Nybo SE, Shaaban KA, Rohr J. Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis. Natural Product Reports. 29: 264-325. PMID 22186970 DOI: 10.1039/c1np00068c  0.52
2011 Sleiman SF, Berlin J, Basso M, Karuppagounder SS, Rohr J, Ratan RR. Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration. Pharmaceuticals (Basel, Switzerland). 4: 1183-1195. PMID 22582024 DOI: 10.3390/ph4081183  0.52
2011 Scott D, Rohr J, Bae Y. Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity. International Journal of Nanomedicine. 6: 2757-67. PMID 22114504 DOI: 10.2147/IJN.S25427  0.52
2011 Wang G, Kharel MK, Pahari P, Rohr J. Investigating Mithramycin deoxysugar biosynthesis: enzymatic total synthesis of TDP-D-olivose. Chembiochem : a European Journal of Chemical Biology. 12: 2568-71. PMID 21960454 DOI: 10.1002/cbic.201100540  0.52
2011 Noinaj N, Bosserman MA, Schickli MA, Piszczek G, Kharel MK, Pahari P, Buchanan SK, Rohr J. The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis. The Journal of Biological Chemistry. 286: 23533-43. PMID 21561854 DOI: 10.1074/jbc.M111.247833  0.44
2011 Sleiman SF, Langley BC, Basso M, Berlin J, Xia L, Payappilly JB, Kharel MK, Guo H, Marsh JL, Thompson LM, Mahishi L, Ahuja P, MacLellan WR, Geschwind DH, Coppola G, ... Rohr J, et al. Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6858-70. PMID 21543616 DOI: 10.1523/JNEUROSCI.0710-11.2011  0.52
2011 Kharel MK, Lian H, Rohr J. Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate. Organic & Biomolecular Chemistry. 9: 1799-808. PMID 21264378 DOI: 10.1039/c0ob00854k  0.52
2011 Bosserman MA, Flórez AB, Shaaban KA, Braña AF, Salas JA, Méndez C, Rohr J. Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus. Biochemistry. 50: 1421-8. PMID 21244022 DOI: 10.1021/bi1016205  0.44
2011 Yang Z, Chi X, Funabashi M, Baba S, Nonaka K, Pahari P, Unrine J, Jacobsen JM, Elliott GI, Rohr J, Van Lanen SG. Characterization of LipL as a non-heme, Fe(II)-dependent α-ketoglutarate:UMP dioxygenase that generates uridine-5'-aldehyde during A-90289 biosynthesis. The Journal of Biological Chemistry. 286: 7885-92. PMID 21216959 DOI: 10.1074/jbc.M110.203562  0.52
2011 Shepherd MD, Liu T, Méndez C, Salas JA, Rohr J. Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties. Applied and Environmental Microbiology. 77: 435-41. PMID 21075894 DOI: 10.1128/AEM.01774-10  0.52
2011 Shaaban KA, Stamatkin C, Damodaran C, Rohr J. 11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain. The Journal of Antibiotics. 64: 141-50. PMID 20978514 DOI: 10.1038/ja.2010.121  0.52
2010 Kharel MK, Shepherd MD, Nybo SE, Smith ML, Bosserman MA, Rohr J. Isolation of Streptomyces species from soil. Current Protocols in Microbiology. Unit 10E.4. PMID 21053254 DOI: 10.1002/9780471729259.mc10e04s19  0.52
2010 Nybo SE, Shepherd MD, Bosserman MA, Rohr J. Genetic manipulation of Streptomyces species. Current Protocols in Microbiology. Unit 10E.3. PMID 21053253 DOI: 10.1002/9780471729259.mc10e03s19  0.52
2010 Bosserman MA, Shepherd MD, Kharel MK, Rohr J. Laboratory maintenance of Streptomyces argillaceus and Streptomyces griseus. Current Protocols in Microbiology. Unit 10E.2. PMID 21053252 DOI: 10.1002/9780471729259.mc10e02s19  0.52
2010 Shepherd MD, Kharel MK, Bosserman MA, Rohr J. Laboratory maintenance of Streptomyces species. Current Protocols in Microbiology. Unit 10E.1. PMID 20812215 DOI: 10.1002/9780471729259.mc10e01s18  0.52
2010 Shepherd MD, Kharel MK, Zhu LL, van Lanen SG, Rohr J. Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity. Organic & Biomolecular Chemistry. 8: 3851-6. PMID 20617244 DOI: 10.1039/c0ob00036a  0.52
2010 Kharel MK, Pahari P, Lian H, Rohr J. Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic. Organic Letters. 12: 2814-7. PMID 20486694 DOI: 10.1021/ol1009009  0.52
2010 Kharel MK, Nybo SE, Shepherd MD, Rohr J. Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters. Chembiochem : a European Journal of Chemical Biology. 11: 523-32. PMID 20140934 DOI: 10.1002/cbic.200900673  0.52
2010 Rohr J, Hertweck C. Type II PKS Comprehensive Natural Products Ii: Chemistry and Biology. 1: 227-303.  0.52
2009 Zhao W, Zhu L, Srinivasan S, Damodaran C, Rohr J. Identification of urushiols as the major active principle of the Siddha herbal medicine Semecarpus Lehyam: Anti-tumor agents for the treatment of breast cancer. Pharmaceutical Biology. 47: 886-893. PMID 20617110 DOI: 10.1080/13880200902942410  0.52
2009 Kharel MK, Pahari P, Lian H, Rohr J. GilR, an unusual lactone-forming enzyme involved in gilvocarcin biosynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 1305-8. PMID 19388008 DOI: 10.1002/cbic.200900130  0.52
2009 Beam MP, Bosserman MA, Noinaj N, Wehenkel M, Rohr J. Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway . Biochemistry. 48: 4476-87. PMID 19364090 DOI: 10.1021/bi8023509  0.52
2009 Pahari P, Rohr J. Total synthesis of psoralidin, an anticancer natural product. The Journal of Organic Chemistry. 74: 2750-4. PMID 19254011 DOI: 10.1021/jo8025884  0.52
2009 Liu T, Kharel MK, Zhu L, Bright SA, Mattingly C, Adams VR, Rohr J. Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity. Chembiochem : a European Journal of Chemical Biology. 10: 278-86. PMID 19067453 DOI: 10.1002/cbic.200800348  0.52
2009 Lombó F, Abdelfattah MS, Braña AF, Salas JA, Rohr J, Méndez C. Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity. Chembiochem : a European Journal of Chemical Biology. 10: 296-303. PMID 18988223 DOI: 10.1002/cbic.200800425  0.52
2008 Pérez M, Baig I, Braña AF, Salas JA, Rohr J, Méndez C. Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis. Chembiochem : a European Journal of Chemical Biology. 9: 2295-304. PMID 18756551 DOI: 10.1002/cbic.200800299  0.44
2008 Abdelfattah MS, Kharel MK, Hitron JA, Baig I, Rohr J. Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002. Journal of Natural Products. 71: 1569-73. PMID 18666798 DOI: 10.1021/np800281f  0.52
2008 Ramos A, Lombó F, Braña AF, Rohr J, Méndez C, Salas JA. Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster. Microbiology (Reading, England). 154: 781-8. PMID 18310024 DOI: 10.1099/mic.0.2007/014035-0  0.52
2008 Olano C, Abdelfattah MS, Gullón S, Braña AF, Rohr J, Méndez C, Salas JA. Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity. Chembiochem : a European Journal of Chemical Biology. 9: 624-33. PMID 18224649 DOI: 10.1002/cbic.200700610  0.44
2008 Baig I, Perez M, Braña AF, Gomathinayagam R, Damodaran C, Salas JA, Méndez C, Rohr J. Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity. Journal of Natural Products. 71: 199-207. PMID 18197601 DOI: 10.1021/np0705763  0.44
2007 Kharel MK, Zhu L, Liu T, Rohr J. Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses. Journal of the American Chemical Society. 129: 3780-1. PMID 17346045 DOI: 10.1021/ja0680515  0.52
2007 Zhu L, Luzhetskyy A, Luzhetska M, Mattingly C, Adams V, Bechthold A, Rohr J. Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem : a European Journal of Chemical Biology. 8: 83-8. PMID 17139690 DOI: 10.1002/cbic.200600360  0.52
2006 Rohr J. Cryptophycin anticancer drugs revisited. Acs Chemical Biology. 1: 747-50. PMID 17240971 DOI: 10.1021/cb6004678  0.52
2006 Pérez M, Lombó F, Baig I, Braña AF, Rohr J, Salas JA, Méndez C. Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses. Applied and Environmental Microbiology. 72: 6644-52. PMID 17021216 DOI: 10.1128/AEM.01266-06  0.52
2006 Abdelfattah MS, Rohr J. Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOII. Angewandte Chemie (International Ed. in English). 45: 5685-9. PMID 16856198 DOI: 10.1002/anie.200600511  0.52
2006 Garrido LM, Lombó F, Baig I, Nur-E-Alam M, Furlan RL, Borda CC, Braña A, Méndez C, Salas JA, Rohr J, Padilla G. Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes. Applied Microbiology and Biotechnology. 73: 122-31. PMID 16810496 DOI: 10.1007/s00253-006-0453-z  0.52
2006 Liu T, Kharel MK, Fischer C, McCormick A, Rohr J. Inactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated. Chembiochem : a European Journal of Chemical Biology. 7: 1070-7. PMID 16795121 DOI: 10.1002/cbic.200600031  0.44
2006 Gullón S, Olano C, Abdelfattah MS, Braña AF, Rohr J, Méndez C, Salas JA. Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin. Applied and Environmental Microbiology. 72: 4172-83. PMID 16751529 DOI: 10.1128/AEM.00734-06  0.44
2006 Menéndez N, Nur-e-Alam M, Fischer C, Braña AF, Salas JA, Rohr J, Méndez C. Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity. Applied and Environmental Microbiology. 72: 167-77. PMID 16391039 DOI: 10.1128/AEM.72.1.167-177.2006  0.44
2005 Wang C, Gibson M, Rohr J, Oliveira MA. Crystallization and X-ray diffraction properties of Baeyer-Villiger monooxygenase MtmOIV from the mithramycin biosynthetic pathway in Streptomyces argillaceus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 1023-6. PMID 16511225 DOI: 10.1107/S1744309105033221  0.52
2005 Salas AP, Zhu L, Sánchez C, Braña AF, Rohr J, Méndez C, Salas JA. Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase. Molecular Microbiology. 58: 17-27. PMID 16164546 DOI: 10.1111/j.1365-2958.2005.04777.x  0.44
2005 Luzhetskyy A, Zhu L, Gibson M, Fedoryshyn M, Dürr C, Hofmann C, Hoffmeister D, Ostash B, Mattingly C, Adams V, Fedorenko V, Rohr J, Bechthold A. Generation of novel landomycins M and O through targeted gene disruption. Chembiochem : a European Journal of Chemical Biology. 6: 675-8. PMID 15812784 DOI: 10.1002/cbic.200400316  0.52
2005 Pérez M, Lombó F, Zhu L, Gibson M, Braña AF, Rohr J, Salas JA, Méndez C. Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins. Chemical Communications (Cambridge, England). 1604-6. PMID 15770274 DOI: 10.1039/b417815g  0.52
2005 Nur-e-Alam M, Méndez C, Salas JA, Rohr J. Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII. Chembiochem : a European Journal of Chemical Biology. 6: 632-6. PMID 15712316 DOI: 10.1002/cbic.200400309  0.44
2005 Sánchez C, Zhu L, Braña AF, Salas AP, Rohr J, Méndez C, Salas JA. Combinatorial biosynthesis of antitumor indolocarbazole compounds. Proceedings of the National Academy of Sciences of the United States of America. 102: 461-6. PMID 15625109 DOI: 10.1073/pnas.0407809102  0.44
2004 Furlan RL, Watt SJ, Garrido LM, Amarante-Mendes GP, Nur-e-alam M, Rohr J, Braña A, Mendez C, Salas JA, Sheil MM, Beck JL, Padilla G. DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains. The Journal of Antibiotics. 57: 647-54. PMID 15638325  0.52
2004 Lombó F, Gibson M, Greenwell L, Braña AF, Rohr J, Salas JA, Méndez C. Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin. Chemistry & Biology. 11: 1709-18. PMID 15610855 DOI: 10.1016/j.chembiol.2004.10.007  0.52
2004 Liu T, Fischer C, Beninga C, Rohr J. Oxidative rearrangement processes in the biosynthesis of gilvocarcin V. Journal of the American Chemical Society. 126: 12262-3. PMID 15453748 DOI: 10.1021/ja0467521  0.52
2004 Menéndez N, Nur-E-Alam M, Braña AF, Rohr J, Salas JA, Méndez C. Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus. Molecular Microbiology. 53: 903-15. PMID 15255901 DOI: 10.1111/j.1365-2958.2004.04166.x  0.44
2004 Menéndez N, Nur-e-Alam M, Braña AF, Rohr J, Salas JA, Méndez C. Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. Chemistry & Biology. 11: 21-32. PMID 15112992 DOI: 10.1016/j.chembiol.2003.12.011  0.44
2003 Fischer C, Lipata F, Rohr J. The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins. Journal of the American Chemical Society. 125: 7818-9. PMID 12822997 DOI: 10.1021/ja034781q  0.52
2002 Fischer C, Rodríguez L, Patallo EP, Lipata F, Braña AF, Méndez C, Salas JA, Rohr J. Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT. Journal of Natural Products. 65: 1685-9. PMID 12444703  0.44
2002 Méndez C, Künzel E, Lipata F, Lombó F, Cotham W, Walla M, Bearden DW, Braña AF, Salas JA, Rohr J. Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891. Journal of Natural Products. 65: 779-82. PMID 12027768 DOI: 10.1021/np010555n  0.52
2002 Sánchez C, Butovich IA, Braña AF, Rohr J, Méndez C, Salas JA. The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chemistry & Biology. 9: 519-31. PMID 11983340  0.44
2000 Rohr J. A new role for polyketides Angewandte Chemie - International Edition. 39: 2847-2849. DOI: 10.1002/1521-3773(20000818)39:16<2847::AID-ANIE2847>3.0.CO;2-0  0.52
1999 Rohr J, Méndez C, Salas JA. The biosynthesis of aureolic acid group antibiotics Bioorganic Chemistry. 27: 41-54. DOI: 10.1006/bioo.1998.1110  0.52
1997 Rohr J. Biosynthesis of Taxol Angewandte Chemie (International Edition in English). 36: 2190-2195.  0.52
1996 Blum S, Groth I, Rohr J, Fielder HP. Biosynthetic capacities of actinomycetes. 5. Dioxolides, novel secondary metabolites from Streptomyces tendae. Journal of Basic Microbiology. 36: 19-25. PMID 8819841  0.52
1995 Rohr J. Combinatorial Biosynthesis–An Approach in the Near Future? Angewandte Chemie International Edition in English. 34: 881-885. DOI: 10.1002/anie.199508811  0.52
1995 Udvarnoki G, Wagner C, Machinek R, Rohr J. Biosynthetic Origin of the Oxygen Atoms of Tetracenomycin C Angewandte Chemie International Edition in English. 34: 565-567. DOI: 10.1002/anie.199505651  0.52
1995 Gerlitz M, Udvarnoki G, Rohr J. Biosyntheses of novel emycins from the mutant strain Streptomyces cellulosae ssp. griseoincarnatus 1114-2 Angewandte Chemie (International Edition in English). 34: 1617-1621.  0.52
1995 Decker H, Haag S, Udvarnoki G, Rohr J. Novel genetically engineered tetracenomycins Angewandte Chemie (International Edition in English). 34: 1107-1110.  0.52
1994 Bockholt H, Beale JM, Rohr J. Biosynthetic investigations on pyridazomycin Angewandte Chemie - International Edition in English. 33: 1647-1651.  0.52
1994 Weber S, Zolke C, Rohr J, Beale JM. Investigations of the biosynthesis and structural revision of landomycin A Journal of Organic Chemistry. 59: 4211-4214.  0.52
1993 Thiericke R, Rohr J. Biological variation of microbial metabolites by precursor-directed biosynthesis Natural Product Reports. 10: 265-289. PMID 8351079 DOI: 10.1039/NP9931000265  0.52
1992 Rohr J, Thiericke R. Angucycline group antibiotics Natural Product Reports. 9: 103-137. PMID 1620493  0.52
1992 Egert E, Noltemeyer M, Siebers J, Rohr J, Zeeck A. The structure of tetracenomycin C Journal of Antibiotics. 45: 1190-1192. PMID 1517166  0.52
1992 Rohr J. Comparison of multicyclic polyketides by folding analysis: A novel approach to recognize biosynthetic and/or evolutionary interrelationships of the natural products or intermediates and its exemplification on hepta-, octa-, and decaketides Journal of Organic Chemistry. 57: 5217-5223. DOI: 10.1021/jo00045a040  0.52
1992 Gerlitz M, Hammann P, Thiericke R, Rohr J. The biogenetic origin of the carbon skeleton and the oxygen atoms of elaiophylin, a symmetric macrodiolide antibiotic Journal of Organic Chemistry. 57: 4030-4033.  0.52
1992 Udvarnoki G, Henkel T, Machinek R, Rohr J. Biosynthetic origin of the oxygen atoms of aquayamycin: Aspects for the biosynthesis of the urdamycin family and for aquayamycin-containing angucycline antibiotics in general Journal of Organic Chemistry. 57: 1274-1276.  0.52
1991 Schonewolf M, Rohr J. Biogenesis of the carbon skeleton of glycerinopyrin: A new biosynthetic pathway for pyrroles Angewandte Chemie - International Edition in English. 30: 183-185.  0.52
1990 Henkel T, Rohr J, Beale JM, Schwenen L. Landomycins, new angucycline antibiotics from Streptomyces SP. I. Structural studies on landomycins A~D Journal of Antibiotics. 43: 492-503. PMID 2358402  0.52
1990 Rohr J, Zeeck A. Structure-activity relationships of elloramycin and tetracenomycin C Journal of Antibiotics. 43: 1169-1178. PMID 2211379  0.52
1990 Rohr J. A novel type of non-enzymatic reaction during the late steps in the biosynthesis of the angucycline antibiotics urdamycins C and D Journal of the Chemical Society, Chemical Communications. 113-114. DOI: 10.1039/C39900000113  0.52
1990 Rohr J. A novel type of ring contraction as non-enzymatic step in the later stages of the biosynthesis of urdamycin H Angewandte Chemie - International Edition in English. 29: 1051-1053.  0.52
1989 Henkel T, Ciesiolka T, Rohr J, Zeeck A. Urdamycins, new angucycline antibiotics from streptomyces fradiae. V. Derivatives of urdamycin A Journal of Antibiotics. 42: 299-311. PMID 2925521  0.52
1989 Rohr J. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. VI. Structure elucidation and biosynthetic investigations on urdamycin H Journal of Antibiotics. 42: 1482-1488. PMID 2808135  0.52
1989 Rohr J, Beale JM, Floss HG. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. IV. Biosynthetic studies of urdamycins A-D. The Journal of Antibiotics. 42: 1151-7. PMID 2753820  0.52
1989 Rohr J. Biosynthetic formation of the S-methyl group of the angucycline antibiotic urdamycin E Journal of the Chemical Society, Chemical Communications. 492-493. DOI: 10.1039/C39890000492  0.52
1988 Rohr J, Zeeck A, Floss HG. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. III. The structures of urdamycins C and D. The Journal of Antibiotics. 41: 126-9. PMID 3346183  0.52
1987 Rohr J, Zeeck A. Metabolic products of microorganisms. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. II. Structural studies of urdamycins B to F Journal of Antibiotics. 40: 459-467. PMID 3583915  0.52
1986 Drautz H, Zahner H, Rohr J, Zeeck A. Metabolic products of microorganisms. 234. Urdamycins, new angucycline antibiotics from Streptomyces fradiae. I. Isolation, characterization and biological properties Journal of Antibiotics. 39: 1657-1669. PMID 3818439  0.52
1986 Fiedler HP, Rohr J, Zeeck A. Elloramycins B, C, D, E, and F: Minor congeners of the elloramycin producer Streptomyces olivaceus Journal of Antibiotics. 39: 856-859. PMID 3755429  0.52
1985 Drautz H, Reuschenbach P, Zahner H, Rohr J, Zeeck A. Metabolic products of microorganisms. 225 Elloramycin, a new anthracycline-like antibiotic from Streptomyces olivaceus. Isolation, characterization, structure and biological properties Journal of Antibiotics. 38: 1291-1301. PMID 3840789  0.52
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