| Year |
Citation |
Score |
| 2019 |
Michel LS, Dyroff S, Brooks FJ, Spayd KJ, Lim S, Engle JT, Phillips S, Tan B, Wang-Gillam A, Bognar C, Chu W, Zhou D, Mach RH, Laforest R, Chen DL. PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies. Radiology. 291: 271. PMID 30897045 DOI: 10.1148/radiol.2019194006 |
0.36 |
|
| 2017 |
Hou C, Hsieh CJ, Li S, Lee H, Graham TJA, Xu K, Weng CC, Doot RK, Chu W, Chakraborty SK, Dugan LL, Mintun MA, Mach R. Development of a PET Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation. Acs Chemical Neuroscience. PMID 29099578 DOI: 10.1021/acschemneuro.7b00385 |
0.36 |
|
| 2017 |
McDonald ES, Mankoff J, Makvandi M, Chu W, Chu Y, Mach RH, Zeng C. Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells. Biochemical and Biophysical Research Communications. PMID 28347815 DOI: 10.1016/j.bbrc.2017.03.122 |
0.36 |
|
| 2016 |
Michel LS, Dyroff S, Brooks FJ, Spayd KJ, Lim S, Engle JT, Phillips S, Tan B, Wang-Gillam A, Bognar C, Chu W, Zhou D, Mach RH, Laforest R, Chen DL. PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies. Radiology. 161929. PMID 27841728 DOI: 10.1148/radiol.2016161929 |
0.36 |
|
| 2016 |
Anderson RC, Makvandi M, Xu K, Lieberman BP, Zeng C, Pryma DA, Mach RH. Iodinated benzimidazole PARP radiotracer for evaluating PARP1/2 expression in vitro and in vivo. Nuclear Medicine and Biology. 43: 752-758. PMID 27689533 DOI: 10.1016/j.nucmedbio.2016.08.007 |
0.36 |
|
| 2016 |
Lee I, Lieberman BP, Li S, Hou C, Makvandi M, Mach RH. Comparative evaluation of 4 and 6-carbon spacer conformationally flexible tetrahydroisoquinolinyl benzamide analogues for imaging the sigma-2 receptor status of solid tumors. Nuclear Medicine and Biology. 43: 721-731. PMID 27589334 DOI: 10.1016/j.nucmedbio.2016.08.001 |
0.36 |
|
| 2016 |
Makvandi M, Xu K, Lieberman BP, Anderson RC, Sander Effron S, Winters HD, Zeng C, McDonald ES, Pryma DA, Greenberg RA, Mach RH. A radiotracer strategy to quantify PARP-1 expression in vivo provides a biomarker that can enable patient selection for PARP inhibitor therapy. Cancer Research. PMID 27261505 DOI: 10.1158/0008-5472.CAN-16-0416 |
0.36 |
|
| 2016 |
Ohman KA, Hashim YM, Vangveravong S, Nywening TM, Cullinan DR, Goedegebuure SP, Liu J, Van Tine BA, Tiriac H, Tuveson DA, DeNardo DG, Spitzer D, Mach RH, Hawkins WG. Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic. Oncotarget. PMID 27244881 DOI: 10.18632/oncotarget.9551 |
0.36 |
|
| 2016 |
Thukkani AK, Shoghi KI, Zhou D, Xu J, Chu W, Novak E, Chen DL, Gropler RJ, Mach RH. PET imaging of in vivo caspase-3/7 activity following myocardial ischemia-reperfusion injury with the radiolabeled isatin sulfonamide analogue [(18)F]WC-4-116. American Journal of Nuclear Medicine and Molecular Imaging. 6: 110-9. PMID 27186438 |
0.36 |
|
| 2016 |
McDonald ES, Mankoff DA, Mach RH. Novel Strategies for Breast Cancer Imaging: New Imaging Agents to Guide Treatment. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 57: 69S-74S. PMID 26834105 DOI: 10.2967/jnumed.115.157925 |
0.36 |
|
| 2015 |
Zhou D, Chu W, Peng X, McConathy J, Mach RH, Katzenellenbogen JA. Facile purification and click labeling with 2-[(18)F]fluoroethyl azide using solid phase extraction cartridges. Tetrahedron Letters. 56: 952-954. PMID 26989269 DOI: 10.1016/j.tetlet.2014.10.126 |
0.36 |
|
| 2015 |
Solingapuram Sai KK, Gage D, Nader M, Mach RH, Mintz A. Improved Automated Radiosynthesis of [(11)C]PBR28. Scientia Pharmaceutica. 83: 413-27. PMID 26839827 DOI: 10.3797/scipharm.1505-06 |
0.36 |
|
| 2015 |
Makvandi M, Tilahun ED, Lieberman BP, Anderson RC, Zeng C, Xu K, Hou C, McDonald ES, Pryma DA, Mach RH. The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer. Biochemical and Biophysical Research Communications. PMID 26453012 DOI: 10.1016/j.bbrc.2015.09.157 |
0.36 |
|
| 2015 |
Luedtke RR, Rangel-Barajas C, Malik M, Reichert DE, Mach RH. Bitropic D3 Dopamine Receptor Selective Compounds s Potential Antipsychotics. Current Pharmaceutical Design. 21: 3700-24. PMID 26205291 |
0.36 |
|
| 2015 |
Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, d'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH. Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils. Journal of Medicinal Chemistry. 58: 6002-17. PMID 26177091 DOI: 10.1021/acs.jmedchem.5b00571 |
0.36 |
|
| 2015 |
Sahlholm K, Liao F, Holtzman DM, Xu J, Mach RH. Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice. Biochemical and Biophysical Research Communications. 460: 439-45. PMID 25796326 DOI: 10.1016/j.bbrc.2015.03.052 |
0.36 |
|
| 2015 |
Wu ZW, Song SY, Li L, Lu HL, Lieberman B, Huang YS, Mach RH. Synthesis and evaluation of tetrahydroindazole derivatives as sigma-2 receptor ligands. Bioorganic & Medicinal Chemistry. 23: 1463-71. PMID 25752422 DOI: 10.1016/j.bmc.2015.02.012 |
0.36 |
|
| 2015 |
Rangel-Barajas C, Malik M, Mach RH, Luedtke RR. Pharmacological modulation of abnormal involuntary DOI-induced head twitch response movements in male DBA/2J mice: II. Effects of D3 dopamine receptor selective compounds. Neuropharmacology. 93: 179-90. PMID 25698528 DOI: 10.1016/j.neuropharm.2014.10.030 |
0.36 |
|
| 2015 |
Malik M, Rangel-Barajas C, Sumien N, Su C, Singh M, Chen Z, Huang RQ, Meunier J, Maurice T, Mach RH, Luedtke RR. The effects of sigma (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. British Journal of Pharmacology. 172: 2519-31. PMID 25573298 DOI: 10.1111/bph.13076 |
0.36 |
|
| 2015 |
Peng X, Wang Q, Mishra Y, Xu J, Reichert DE, Malik M, Taylor M, Luedtke RR, Mach RH. Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry Letters. 25: 519-23. PMID 25556097 DOI: 10.1016/j.bmcl.2014.12.023 |
0.36 |
|
| 2015 |
Huang HJ, Isakow W, Byers DE, Engle JT, Griffin EA, Kemp D, Brody SL, Gropler RJ, Miller JP, Chu W, Zhou D, Pierce RA, Castro M, Mach RH, Chen DL. Imaging pulmonary inducible nitric oxide synthase expression with PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 56: 76-81. PMID 25525182 DOI: 10.2967/jnumed.114.146381 |
0.36 |
|
| 2015 |
Chen DL, Engle JT, Griffin EA, Miller JP, Chu W, Zhou D, Mach RH. Imaging caspase-3 activation as a marker of apoptosis-targeted treatment response in cancer. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 17: 384-93. PMID 25344147 DOI: 10.1007/s11307-014-0802-8 |
0.36 |
|
| 2015 |
Xie F, Kniess T, Neuber C, Deuther-Conrad W, Mamat C, Lieberman BP, Liu B, Mach RH, Brust P, Steinbach J, Pietzsch J, Jia H. Novel indole-based sigma-2 receptor ligands: synthesis, structure-affinity relationship and antiproliferative activity Medchemcomm. 6: 1093-1103. DOI: 10.1039/c5md00079c |
0.36 |
|
| 2015 |
Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, D'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH. Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils Journal of Medicinal Chemistry. 58: 6002-6017. DOI: 10.1021/acs.jmedchem.5b00571 |
0.36 |
|
| 2015 |
Zhou D, Chu W, Peng X, McConathy J, Mach RH, Katzenellenbogen JA. Facile purification and click labeling with 2-[18F]fluoroethyl azide using solid phase extraction cartridges Tetrahedron Letters. 56: 952-954. DOI: 10.1016/j.tetlet.2014.10.126 |
0.36 |
|
| 2015 |
Zeng C, Garg N, Mach RH. The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells Molecular Imaging and Biology. DOI: 10.1007/s11307-015-0891-z |
0.36 |
|
| 2014 |
Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, ... Mach RH, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Plos One. 9: e111899. PMID 25390692 DOI: 10.1371/journal.pone.0111899 |
0.36 |
|
| 2014 |
Rangel-Barajas C, Malik M, Taylor M, Neve KA, Mach RH, Luedtke RR. Characterization of [(3) H]LS-3-134, a novel arylamide phenylpiperazine D3 dopamine receptor selective radioligand. Journal of Neurochemistry. 131: 418-31. PMID 25041389 DOI: 10.1111/jnc.12825 |
0.36 |
|
| 2014 |
Mach RH. New targets for the development of PET tracers for imaging neurodegeneration in Alzheimer disease. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 55: 1221-4. PMID 25034093 DOI: 10.2967/jnumed.114.127811 |
0.36 |
|
| 2014 |
Sai KK, Fan J, Tu Z, Zerkel P, Mach RH, Kharasch ED. Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM). Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine. 91: 135-40. PMID 24935116 DOI: 10.1016/j.apradiso.2014.05.019 |
0.36 |
|
| 2014 |
Chu W, Chepetan A, Zhou D, Shoghi KI, Xu J, Dugan LL, Gropler RJ, Mintun MA, Mach RH. Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo. Organic & Biomolecular Chemistry. 12: 4421-31. PMID 24847866 DOI: 10.1039/c3ob42379d |
0.36 |
|
| 2014 |
Bai S, Li S, Xu J, Peng X, Sai K, Chu W, Tu Z, Zeng C, Mach RH. Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands. Journal of Medicinal Chemistry. 57: 4239-51. PMID 24821398 DOI: 10.1021/jm5001453 |
0.36 |
|
| 2014 |
Hashim YM, Spitzer D, Vangveravong S, Hornick MC, Garg G, Hornick JR, Goedegebuure P, Mach RH, Hawkins WG. Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134. Molecular Oncology. 8: 956-67. PMID 24731702 DOI: 10.1016/j.molonc.2014.03.005 |
0.36 |
|
| 2014 |
Rangel-Barajas C, Malik M, Vangveravong S, Mach RH, Luedtke RR. Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds. Neuropharmacology. 83: 18-27. PMID 24680675 DOI: 10.1016/j.neuropharm.2014.03.003 |
0.36 |
|
| 2014 |
Sun T, Wang Y, Wang Y, Xu J, Zhao X, Vangveravong S, Mach RH, Xia Y. Using SV119-gold nanocage conjugates to eradicate cancer stem cells through a combination of photothermal and chemo therapies. Advanced Healthcare Materials. 3: 1283-91. PMID 24677807 DOI: 10.1002/adhm.201400026 |
0.36 |
|
| 2014 |
Garg G, Vangveravong S, Zeng C, Collins L, Hornick M, Hashim Y, Piwnica-Worms D, Powell MA, Mutch DG, Mach RH, Hawkins WG, Spitzer D. Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer. Molecular Cancer. 13: 50. PMID 24602489 DOI: 10.1186/1476-4598-13-50 |
0.36 |
|
| 2014 |
Zhou D, Chu W, Xu J, Jones LA, Peng X, Li S, Chen DL, Mach RH. Synthesis, [¹⁸F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorganic & Medicinal Chemistry. 22: 1700-7. PMID 24503274 DOI: 10.1016/j.bmc.2014.01.019 |
0.36 |
|
| 2014 |
Gräff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, Holson E, Xu J, Sun J, Neve RL, Mach RH, et al. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell. 156: 261-76. PMID 24439381 DOI: 10.1016/j.cell.2013.12.020 |
0.36 |
|
| 2014 |
Zeng C, Rothfuss JM, Zhang J, Vangveravong S, Chu W, Li S, Tu Z, Xu J, Mach RH. Functional assays to define agonists and antagonists of the sigma-2 receptor. Analytical Biochemistry. 448: 68-74. PMID 24333652 DOI: 10.1016/j.ab.2013.12.008 |
0.36 |
|
| 2013 |
Sun J, Kouranova E, Cui X, Mach RH, Xu J. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Neuroscience Letters. 557: 123-8. PMID 24157858 DOI: 10.1016/j.neulet.2013.10.034 |
0.36 |
|
| 2013 |
Tu Z, Li S, Li A, Taylor M, Ho D, Malik M, Luedtke RR, Mach RH. Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands. Medchemcomm. 4: 1283-1289. PMID 24156012 DOI: 10.1039/C3MD00098B |
0.36 |
|
| 2013 |
Zeng C, Vangveravong S, McDunn JE, Hawkins WG, Mach RH. Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer. British Journal of Cancer. 109: 2368-77. PMID 24104966 DOI: 10.1038/bjc.2013.593 |
0.36 |
|
| 2013 |
Shoghi KI, Xu J, Su Y, He J, Rowland D, Yan Y, Garbow JR, Tu Z, Jones LA, Higashikubo R, Wheeler KT, Lubet RA, Mach RH, You M. Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1. Plos One. 8: e74188. PMID 24073202 DOI: 10.1371/journal.pone.0074188 |
0.36 |
|
| 2013 |
Cheung TH, Loriaux AL, Weber SM, Chandler KN, Lenz JD, Schaan RF, Mach RH, Luedtke RR, Neisewander JL. Reduction of cocaine self-administration and D3 receptor-mediated behavior by two novel dopamine D3 receptor-selective partial agonists, OS-3-106 and WW-III-55. The Journal of Pharmacology and Experimental Therapeutics. 347: 410-23. PMID 24018640 DOI: 10.1124/jpet.112.202911 |
0.36 |
|
| 2013 |
Huang R, Griffin SA, Taylor M, Vangveravong S, Mach RH, Dillon GH, Luedtke RR. The effect of SV 293, a D2 dopamine receptor-selective antagonist, on D2 receptor-mediated GIRK channel activation and adenylyl cyclase inhibition. Pharmacology. 92: 84-9. PMID 23942137 DOI: 10.1159/000351971 |
0.36 |
|
| 2013 |
Nolan BC, Liu S, Hammerslag LR, Cheung TH, Lenz J, Mach RH, Luedtke RR, Neisewander JL. Fos expression in response to dopamine D3-preferring phenylpiperazine drugs given with and without cocaine. Synapse (New York, N.Y.). 67: 847-55. PMID 23766142 DOI: 10.1002/syn.21691 |
0.36 |
|
| 2013 |
Mach RH, Zeng C, Hawkins WG. The σ2 receptor: a novel protein for the imaging and treatment of cancer. Journal of Medicinal Chemistry. 56: 7137-60. PMID 23734634 DOI: 10.1021/jm301545c |
0.36 |
|
| 2013 |
Sun J, Cairns NJ, Perlmutter JS, Mach RH, Xu J. Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. 248: 112-26. PMID 23732230 DOI: 10.1016/j.neuroscience.2013.05.048 |
0.36 |
|
| 2013 |
Sai KK, Huang C, Yuan L, Zhou D, Piwnica-Worms D, Garbow JR, Engelbach JA, Mach RH, Rich KM, McConathy J. 18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 1120-6. PMID 23650628 DOI: 10.2967/jnumed.112.113217 |
0.36 |
|
| 2013 |
Li A, Mishra Y, Malik M, Wang Q, Li S, Taylor M, Reichert DE, Luedtke RR, Mach RH. Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands. Bioorganic & Medicinal Chemistry. 21: 2988-98. PMID 23618707 DOI: 10.1016/j.bmc.2013.03.074 |
0.36 |
|
| 2013 |
Sai KK, Jones LA, Mach RH. Development of (18)F-labeled PET probes for imaging cell proliferation. Current Topics in Medicinal Chemistry. 13: 892-908. PMID 23590172 DOI: 10.2174/1568026611313080003 |
0.36 |
|
| 2013 |
Bagchi DP, Yu L, Perlmutter JS, Xu J, Mach RH, Tu Z, Kotzbauer PT. Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent Plos One. 8. PMID 23405108 DOI: 10.1371/journal.pone.0055031 |
0.36 |
|
| 2013 |
Dehdashti F, Laforest R, Gao F, Shoghi KI, Aft RL, Nussenbaum B, Kreisel FH, Bartlett NL, Cashen A, Wagner-Johnson N, MacH RH. Assessment of cellular proliferation in tumors by PET using 18F-ISO-1 Journal of Nuclear Medicine. 54: 350-357. PMID 23359657 DOI: 10.2967/jnumed.112.111948 |
0.36 |
|
| 2013 |
Xu J, Vangveravong S, Li S, Fan J, Jones LA, Cui J, Wang R, Tu Z, Chu W, Perlmutter JS, Mach RH. Positron emission tomography imaging of dopamine D2 receptors using a highly selective radiolabeled D2 receptor partial agonist Neuroimage. 71: 168-174. PMID 23333701 DOI: 10.1016/j.neuroimage.2013.01.007 |
0.36 |
|
| 2013 |
Yang C, Davis JL, Zeng R, Vora P, Su X, Collins LI, Vangveravong S, Mach RH, Piwnica-Worms D, Weilbaecher KN, Faccio R, Novack DV. Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation. Cancer Discovery. 3: 212-23. PMID 23269702 DOI: 10.1158/2159-8290.CD-12-0271 |
0.36 |
|
| 2012 |
Luedtke RR, Mishra Y, Wang Q, Griffin SA, Bell-Horner C, Taylor M, Vangveravong S, Dillon GH, Huang RQ, Reichert DE, Mach RH. Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds. Acs Chemical Neuroscience. 3: 1050-62. PMID 23259040 DOI: 10.1021/cn300142q |
0.36 |
|
| 2012 |
Sun J, Xu J, Cairns NJ, Perlmutter JS, Mach RH. Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain. Plos One. 7: e49483. PMID 23185343 DOI: 10.1371/journal.pone.0049483 |
0.36 |
|
| 2012 |
Cheung TH, Nolan BC, Hammerslag LR, Weber SM, Durbin JP, Peartree NA, Mach RH, Luedtke RR, Neisewander JL. Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats. Neuropharmacology. 63: 1346-59. PMID 22960444 DOI: 10.1016/j.neuropharm.2012.08.011 |
0.36 |
|
| 2012 |
Solingapuram Sai KK, Kil KE, Tu Z, Chu W, Finck BN, Rothfuss JM, Shoghi KI, Welch MJ, Gropler RJ, Mach RH. Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors. Bioorganic & Medicinal Chemistry Letters. 22: 6233-6. PMID 22939697 DOI: 10.1016/j.bmcl.2012.08.010 |
0.36 |
|
| 2012 |
Moussa IA, Banister SD, Manoli M, Doddareddy MR, Cui J, Mach RH, Kassiou M. Exploration of ring size in a series of cyclic vicinal diamines with σ₁ receptor affinity. Bioorganic & Medicinal Chemistry Letters. 22: 5493-7. PMID 22850210 DOI: 10.1016/j.bmcl.2012.07.026 |
0.36 |
|
| 2012 |
Zhou D, Chu W, Dence CS, Mach RH, Welch MJ. Highly efficient click labeling using 2-[¹⁸F]fluoroethyl azide and synthesis of an ¹⁸FN-hydroxysuccinimide ester as conjugation agent. Nuclear Medicine and Biology. 39: 1175-81. PMID 22770647 DOI: 10.1016/j.nucmedbio.2012.06.002 |
0.36 |
|
| 2012 |
Hornick JR, Spitzer D, Goedegebuure P, Mach RH, Hawkins WG. Therapeutic targeting of pancreatic cancer utilizing sigma-2 ligands. Surgery. 152: S152-6. PMID 22763259 DOI: 10.1016/j.surg.2012.05.014 |
0.36 |
|
| 2012 |
Hornick JR, Vangveravong S, Spitzer D, Abate C, Berardi F, Goedegebuure P, Mach RH, Hawkins WG. Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer. Journal of Experimental & Clinical Cancer Research : Cr. 31: 41. PMID 22551149 DOI: 10.1186/1756-9966-31-41 |
0.36 |
|
| 2012 |
Tian L, Karimi M, Loftin SK, Brown CA, Xia H, Xu J, Mach RH, Perlmutter JS. No differential regulation of dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) binding in a primate model of Parkinson disease. Plos One. 7: e31439. PMID 22359591 DOI: 10.1371/journal.pone.0031439 |
0.36 |
|
| 2012 |
Luedtke RR, Perez E, Yang SH, Liu R, Vangveravong S, Tu Z, Mach RH, Simpkins JW. Neuroprotective effects of high affinity Σ1 receptor selective compounds. Brain Research. 1441: 17-26. PMID 22285434 DOI: 10.1016/j.brainres.2011.12.047 |
0.36 |
|
| 2012 |
Zeng C, Rothfuss J, Zhang J, Chu W, Vangveravong S, Tu Z, Pan F, Chang KC, Hotchkiss R, Mach RH. Sigma-2 ligands induce tumour cell death by multiple signalling pathways. British Journal of Cancer. 106: 693-701. PMID 22251921 DOI: 10.1038/bjc.2011.602 |
0.36 |
|
| 2012 |
Wang Y, Xu J, Xia X, Yang M, Vangveravong S, Chen J, Mach RH, Xia Y. SV119-gold nanocage conjugates: a new platform for targeting cancer cells via sigma-2 receptors. Nanoscale. 4: 421-4. PMID 22113350 DOI: 10.1039/c1nr11469g |
0.36 |
|
| 2012 |
Spitzer D, Simon PO, Kashiwagi H, Xu J, Zeng C, Vangveravong S, Zhou D, Chang K, McDunn JE, Hornick JR, Goedegebuure P, Hotchkiss RS, Mach RH, Hawkins WG. Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling. Cancer Research. 72: 201-9. PMID 22065721 DOI: 10.1158/0008-5472.CAN-11-1354 |
0.36 |
|
| 2012 |
Chen DL, Zhou D, Chu W, Herrbrich P, Engle JT, Griffin E, Jones LA, Rothfuss JM, Geraci M, Hotchkiss RS, Mach RH. Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody. Nuclear Medicine and Biology. 39: 137-44. PMID 22033021 DOI: 10.1016/j.nucmedbio.2011.08.001 |
0.36 |
|
| 2012 |
Lee H, Chen DL, Rothfuss JM, Welch MJ, Gropler RJ, Mach RH. Synthesis and evaluation of 18F-labeled PPARγ antagonists. Nuclear Medicine and Biology. 39: 77-87. PMID 21907585 DOI: 10.1016/j.nucmedbio.2011.07.002 |
0.36 |
|
| 2012 |
Haller JL, Panyutin I, Chaudhry A, Zeng C, Mach RH, Frank JA. Sigma-2 receptor as potential indicator of stem cell differentiation. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 14: 325-35. PMID 21614680 DOI: 10.1007/s11307-011-0493-3 |
0.36 |
|
| 2011 |
Zeng C, Vangveravong S, Jones LA, Hyrc K, Chang KC, Xu J, Rothfuss JM, Goldberg MP, Hotchkiss RS, Mach RH. Characterization and evaluation of two novel fluorescent sigma-2 receptor ligands as proliferation probes. Molecular Imaging. 10: 420-33. PMID 22201533 DOI: 10.2310/7290.2011.00009 |
0.36 |
|
| 2011 |
Han BH, Zhou ML, Vellimana AK, Milner E, Kim DH, Greenberg JK, Chu W, Mach RH, Zipfel GJ. Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy. Molecular Neurodegeneration. 6: 86. PMID 22192811 DOI: 10.1186/1750-1326-6-86 |
0.36 |
|
| 2011 |
Brown JA, Xu J, Diggs-Andrews KA, Wozniak DF, Mach RH, Gutmann DH. PET imaging for attention deficit preclinical drug testing in neurofibromatosis-1 mice. Experimental Neurology. 232: 333-8. PMID 21963652 DOI: 10.1016/j.expneurol.2011.09.005 |
0.36 |
|
| 2011 |
Banister SD, Yoo DT, Chua SW, Cui J, Mach RH, Kassiou M. N-Arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (σ) receptor ligands. Bioorganic & Medicinal Chemistry Letters. 21: 5289-92. PMID 21788137 DOI: 10.1016/j.bmcl.2011.07.028 |
0.36 |
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| 2011 |
Xu J, Zeng C, Chu W, Pan F, Rothfuss JM, Zhang F, Tu Z, Zhou D, Zeng D, Vangveravong S, Johnston F, Spitzer D, Chang KC, Hotchkiss RS, Hawkins WG, ... ... Mach RH, et al. Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nature Communications. 2: 380. PMID 21730960 DOI: 10.1038/ncomms1386 |
0.36 |
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| 2011 |
Tu Z, Li S, Xu J, Chu W, Jones LA, Luedtke RR, Mach RH. Effect of cyclosporin A on the uptake of D3-selective PET radiotracers in rat brain. Nuclear Medicine and Biology. 38: 725-39. PMID 21718948 DOI: 10.1016/j.nucmedbio.2011.01.002 |
0.36 |
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| 2011 |
Zhang Z, Lu X, Xu J, Rothfuss J, Mach RH, Tu Z. Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A. European Journal of Medicinal Chemistry. 46: 3986-95. PMID 21705115 DOI: 10.1016/j.ejmech.2011.05.072 |
0.36 |
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| 2011 |
Lim MM, Xu J, Holtzman DM, Mach RH. Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum. Neuroreport. 22: 489-93. PMID 21642879 DOI: 10.1097/WNR.0b013e32834846a0 |
0.36 |
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| 2011 |
Vangveravong S, Zhang Z, Taylor M, Bearden M, Xu J, Cui J, Wang W, Luedtke RR, Mach RH. Synthesis and characterization of selective dopamine D₂ receptor ligands using aripiprazole as the lead compound. Bioorganic & Medicinal Chemistry. 19: 3502-11. PMID 21536445 DOI: 10.1016/j.bmc.2011.04.021 |
0.36 |
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| 2011 |
Chu W, Rothfuss J, Zhou D, Mach RH. Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay. Bioorganic & Medicinal Chemistry Letters. 21: 2192-7. PMID 21441025 DOI: 10.1016/j.bmcl.2011.03.015 |
0.36 |
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| 2011 |
Tu Z, Li S, Cui J, Xu J, Taylor M, Ho D, Luedtke RR, Mach RH. Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands. Journal of Medicinal Chemistry. 54: 1555-64. PMID 21348515 DOI: 10.1021/jm101323b |
0.36 |
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| 2011 |
Kharasch ED, Vangveravong S, Buck N, London A, Kim T, Blood J, MacH RH. Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil Clinical Pharmacology and Therapeutics. 89: 562-570. PMID 21346758 DOI: 10.1038/clpt.2010.313 |
0.36 |
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| 2011 |
Tu Z, Fan J, Li S, Jones LA, Cui J, Padakanti PK, Xu J, Zeng D, Shoghi KI, Perlmutter JS, MacH RH. Radiosynthesis and in vivo evaluation of [ 11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain Bioorganic and Medicinal Chemistry. 19: 1666-1673. PMID 21315609 DOI: 10.1016/j.bmc.2011.01.032 |
0.36 |
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| 2011 |
Mach RH, Tu Z, Xu J, Li S, Jones LA, Taylor M, Luedtke RR, Derdeyn CP, Perlmutter JS, Mintun MA. Endogenous dopamine (DA) competes with the binding of a radiolabeled D3 receptor partial agonist in vivo: A positron emission tomography study Synapse. 65: 724-732. PMID 21132811 DOI: 10.1002/syn.20891 |
0.36 |
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| 2011 |
Fan J, Meissner K, Gaehle GG, Li S, Kharasch ED, Mach RH, Tu Z. Automated radiosynthesis of [11C]morphine for clinical investigation. Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine. 69: 431-5. PMID 21112214 DOI: 10.1016/j.apradiso.2010.11.003 |
0.36 |
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| 2011 |
Karimi M, Moerlein SM, Videen TO, Luedtke RR, Taylor M, Mach RH, Perlmutter JS. Decreased striatal dopamine receptor binding in primary focal dystonia: A D2 or D3 defect? Movement Disorders. 26: 100-106. PMID 20960437 DOI: 10.1002/mds.23401 |
0.36 |
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| 2010 |
Mach RH, Schwarz SW. Challenges for Developing PET Tracers: Isotopes, Chemistry, and Regulatory Aspects. Pet Clinics. 5: 131-53. PMID 27157669 DOI: 10.1016/j.cpet.2010.02.002 |
0.36 |
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| 2010 |
Hornick JR, Xu J, Vangveravong S, Tu Z, Mitchem JB, Spitzer D, Goedegebuure P, Mach RH, Hawkins WG. The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. Molecular Cancer. 9: 298. PMID 21092190 DOI: 10.1186/1476-4598-9-298 |
0.36 |
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| 2010 |
McConathy J, Zhou D, Shockley SE, Jones LA, Griffin EA, Lee H, Adams SJ, Mach RH. Click synthesis and biologic evaluation of (R)- and (S)-2-amino-3-[1-(2-[18F]fluoroethyl)-1H-[1,2,3]triazol-4-yl]propanoic acid for brain tumor imaging with positron emission tomography. Molecular Imaging. 9: 329-42. PMID 21084029 DOI: 10.2310/7290.2010.00025 |
0.36 |
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| 2010 |
Tu Z, Li S, Sharp TL, Herrero P, Dence CS, Gropler RJ, Mach RH. Synthesis and evaluation of 15-(4-(2-[¹â¸F]Fluoroethoxy)phenyl)pentadecanoic acid: a potential PET tracer for studying myocardial fatty acid metabolism. Bioconjugate Chemistry. 21: 2313-9. PMID 21070001 DOI: 10.1021/bc100343h |
0.36 |
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| 2010 |
Wang Q, Mach RH, Luedtke RR, Reichert DE. Subtype selectivity of dopamine receptor ligands: insights from structure and ligand-based methods. Journal of Chemical Information and Modeling. 50: 1970-85. PMID 20936866 DOI: 10.1021/ci1002747 |
0.36 |
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| 2010 |
Vlassenko AG, Vaishnavi SN, Couture L, Sacco D, Shannon BJ, Mach RH, Morris JC, Raichle ME, Mintun MA. Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition. Proceedings of the National Academy of Sciences of the United States of America. 107: 17763-7. PMID 20837517 DOI: 10.1073/pnas.1010461107 |
0.36 |
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| 2010 |
Tu Z, Xu J, Jones LA, Li S, Zeng D, Kung MP, Kung HF, Mach RH. Radiosynthesis and biological evaluation of a promising sigma(2)-receptor ligand radiolabeled with fluorine-18 or iodine-125 as a PET/SPECT probe for imaging breast cancer. Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine. 68: 2268-73. PMID 20594864 DOI: 10.1016/j.apradiso.2010.06.004 |
0.36 |
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| 2010 |
Vangveravong S, Taylor M, Xu J, Cui J, Calvin W, Babic S, Luedtke RR, Mach RH. Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626. Bioorganic & Medicinal Chemistry. 18: 5291-300. PMID 20542439 DOI: 10.1016/j.bmc.2010.05.052 |
0.36 |
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| 2010 |
Tu Z, Xu J, Jones LA, Li S, Mach RH. Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation. Nuclear Medicine and Biology. 37: 509-16. PMID 20447563 DOI: 10.1016/j.nucmedbio.2009.12.012 |
0.36 |
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| 2010 |
Tu Z, Mach RH. C-11 radiochemistry in cancer imaging applications Current Topics in Medicinal Chemistry. 10: 1060-1095. PMID 20388115 DOI: 10.2174/156802610791384261 |
0.36 |
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| 2010 |
Dence CS, Laforest R, Sun X, Sharp TL, Welch MJ, Mach RH. Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [¹¹C] methylated LY2181308. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 12: 608-15. PMID 20376567 DOI: 10.1007/s11307-010-0319-8 |
0.36 |
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| 2010 |
Efange SM, Khare AB, von Hohenberg K, Mach RH, Parsons SM, Tu Z. Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter. Journal of Medicinal Chemistry. 53: 2825-35. PMID 20218624 DOI: 10.1021/jm9017916 |
0.36 |
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| 2010 |
Xu J, Hassanzadeh B, Chu W, Tu Z, Jones LA, Luedtke RR, Perlmutter JS, Mintun MA, Mach RH. [3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)- butyl)benzamide: A selective radioligand for dopamine D3 receptors. II. Quantitative analysis of dopamine D3 and D2 receptor density ratio in the caudate-putamen Synapse. 64: 449-459. PMID 20175227 DOI: 10.1002/syn.20748 |
0.36 |
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| 2010 |
Zeng C, Pan F, Jones LA, Lim MM, Griffin EA, Sheline YI, Mintun MA, Holtzman DM, Mach RH. Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system. Brain Research. 1319: 21-32. PMID 20064490 DOI: 10.1016/j.brainres.2009.12.092 |
0.36 |
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| 2009 |
Mach RH. Preface. Pet Clinics. 4: ix-x. PMID 27156897 DOI: 10.1016/j.cpet.2009.06.005 |
0.36 |
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| 2009 |
Fagan AM, Mintun MA, Shah AR, Aldea P, Roe CM, Mach RH, Marcus D, Morris JC, Holtzman DM. Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease. Embo Molecular Medicine. 1: 371-80. PMID 20049742 DOI: 10.1002/emmm.200900048 |
0.36 |
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| 2009 |
Mach RH, Dehdashti F, Wheeler KT. PET Radiotracers for Imaging the Proliferative Status of Solid Tumors. Pet Clinics. 4: 1-15. PMID 20046891 DOI: 10.1016/j.cpet.2009.04.012 |
0.36 |
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| 2009 |
Mach RH, Wheeler KT. Development of molecular probes for imaging sigma-2 receptors in vitro and in vivo Central Nervous System Agents in Medicinal Chemistry. 9: 230-245. PMID 20021357 |
0.36 |
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| 2009 |
Chen DL, Zhou D, Chu W, Herrbrich PE, Jones LA, Rothfuss JM, Engle JT, Geraci M, Welch MJ, Mach RH. Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography. Nuclear Medicine and Biology. 36: 651-8. PMID 19647171 DOI: 10.1016/j.nucmedbio.2009.03.008 |
0.36 |
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| 2009 |
Wang Q, Mach RH, Reichert DE. Docking and 3D-QSAR studies on isatin sulfonamide analogues as caspase-3 inhibitors. Journal of Chemical Information and Modeling. 49: 1963-73. PMID 19610597 DOI: 10.1021/ci900144x |
0.36 |
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| 2009 |
Weber M, Chang WL, Durbin JP, Park PE, Luedtke RR, Mach RH, Swerdlow NR. Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44. Pharmacology, Biochemistry, and Behavior. 93: 141-7. PMID 19426754 DOI: 10.1016/j.pbb.2009.04.022 |
0.36 |
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| 2009 |
Xu J, Chu W, Tu Z, Jones LA, Luedtke RR, Perlmutter JS, Mintun MA, Mach RH. [3H]4-(dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl]benzamide, a selective radioligand for dopamine D3 receptors. I. In vitro characterization Synapse. 63: 717-728. PMID 19425052 DOI: 10.1002/syn.20652 |
0.36 |
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| 2009 |
Kumar R, Riddle LR, Griffin SA, Chu W, Vangveravong S, Neisewander J, Mach RH, Luedtke RR. Evaluation of D2 and D3 dopamine receptor selective compounds on l-dopa-dependent abnormal involuntary movements in rats Neuropharmacology. 56: 956-969. PMID 19371586 DOI: 10.1016/j.neuropharm.2009.01.019 |
0.36 |
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| 2009 |
Chu W, Rothfuss J, Chu Y, Zhou D, Mach RH. Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. Journal of Medicinal Chemistry. 52: 2188-91. PMID 19326941 DOI: 10.1021/jm900135r |
0.36 |
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| 2009 |
Kashiwagi H, McDunn JE, Simon PO, Goedegebuure PS, Vangveravong S, Chang K, Hotchkiss RS, Mach RH, Hawkins WG. Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma. Journal of Translational Medicine. 7: 24. PMID 19323815 DOI: 10.1186/1479-5876-7-24 |
0.36 |
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| 2009 |
Zhou D, Lee H, Rothfuss JM, Chen DL, Ponde DE, Welch MJ, Mach RH. Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase. Journal of Medicinal Chemistry. 52: 2443-53. PMID 19323559 DOI: 10.1021/jm801556h |
0.36 |
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| 2009 |
Zhou D, Chu W, Chen DL, Wang Q, Reichert DE, Rothfuss J, D'Avignon A, Welch MJ, Mach RH. [18F]- and [11C]-labeled N-benzyl-isatin sulfonamide analogues as PET tracers for apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98. Organic & Biomolecular Chemistry. 7: 1337-48. PMID 19300818 DOI: 10.1039/b819024k |
0.36 |
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| 2009 |
Tu Z, Efange SM, Xu J, Li S, Jones LA, Parsons SM, Mach RH. Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter. Journal of Medicinal Chemistry. 52: 1358-69. PMID 19203271 DOI: 10.1021/jm8012344 |
0.36 |
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| 2009 |
Chu W, Xu J, Zhou D, Zhang F, Jones LA, Wheeler KT, Mach RH. New N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl phenylcarbamate analogs as sigma2 receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents. Bioorganic & Medicinal Chemistry. 17: 1222-31. PMID 19119012 DOI: 10.1016/j.bmc.2008.12.025 |
0.36 |
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| 2007 |
Zeng C, Vangveravong S, Xu J, Chang KC, Hotchkiss RS, Wheeler KT, Shen D, Zhuang ZP, Kung HF, Mach RH. Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Research. 67: 6708-16. PMID 17638881 DOI: 10.1158/0008-5472.CAN-06-3803 |
0.36 |
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| 2007 |
Chu W, Rothfuss J, d'Avignon A, Zeng C, Zhou D, Hotchkiss RS, Mach RH. Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. Journal of Medicinal Chemistry. 50: 3751-5. PMID 17585855 DOI: 10.1021/jm070506t |
0.36 |
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| 2007 |
Tu Z, Xu J, Jones LA, Li S, Dumstorff C, Vangveravong S, Chen DL, Wheeler KT, Welch MJ, Mach RH. Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography. Journal of Medicinal Chemistry. 50: 3194-204. PMID 17579383 DOI: 10.1021/jm0614883 |
0.36 |
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| 2007 |
Lee BC, Lee KC, Lee H, Mach RH, Katzenellenbogen JA. Strategies for the labeling of halogen-substituted peroxisome proliferator-activated receptor gamma ligands: potential positron emission tomography and single photon emission computed tomography imaging agents. Bioconjugate Chemistry. 18: 514-23. PMID 17315977 DOI: 10.1021/bc060191g |
0.36 |
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| 2007 |
Lee BC, Lee KC, Lee H, Mach RH, Katzenellenbogen JA. Synthesis and binding affinity of a fluorine-substituted peroxisome proliferator-activated gamma (PPARgamma) ligand as a potential positron emission tomography (PET) imaging agent. Bioconjugate Chemistry. 18: 507-13. PMID 17309226 DOI: 10.1021/bc060190o |
0.36 |
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| 2007 |
Jost SC, Wanebo JE, Song SK, Chicoine MR, Rich KM, Woolsey TA, Lewis JS, Mach RH, Xu J, Garbow JR. In vivo imaging in a murine model of glioblastoma. Neurosurgery. 60: 360-70; discussion 3. PMID 17290188 DOI: 10.1227/01.NEU.0000249264.80579.37 |
0.36 |
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| 2007 |
Mach RH, Wheeler KT. Imaging the proliferative status of tumors with PET Journal of Labelled Compounds and Radiopharmaceuticals. 50: 366-369. DOI: 10.1002/jlcr.1269 |
0.36 |
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| 2006 |
Lee H, Finck BN, Jones LA, Welch MJ, Mach RH. Synthesis and evaluation of a bromine-76-labeled PPARgamma antagonist 2-bromo-5-nitro-N-phenylbenzamide. Nuclear Medicine and Biology. 33: 847-54. PMID 17045164 DOI: 10.1016/j.nucmedbio.2006.08.003 |
0.36 |
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| 2006 |
Mintun MA, Larossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology. 67: 446-52. PMID 16894106 DOI: 10.1212/01.wnl.0000228230.26044.a4 |
0.36 |
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| 2006 |
Zhou D, Chu W, Rothfuss J, Zeng C, Xu J, Jones L, Welch MJ, Mach RH. Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis. Bioorganic & Medicinal Chemistry Letters. 16: 5041-6. PMID 16891117 DOI: 10.1016/j.bmcl.2006.07.045 |
0.36 |
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| 2006 |
Vangveravong S, Xu J, Zeng C, Mach RH. Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl carbamate analogs as σ2 receptor ligands Bioorganic and Medicinal Chemistry. 14: 6988-6997. PMID 16837201 DOI: 10.1016/j.bmc.2006.06.028 |
0.36 |
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| 2006 |
Nader MA, Morgan D, Gage HD, Nader SH, Calhoun TL, Buchheimer N, Ehrenkaufer R, Mach RH. PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys. Nature Neuroscience. 9: 1050-6. PMID 16829955 DOI: 10.1038/nn1737 |
0.36 |
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| 2006 |
Rowland DJ, Tu Z, Xu J, Ponde D, Mach RH, Welch MJ. Synthesis and in vivo evaluation of 2 high-affinity 76Br-labeled sigma2-receptor ligands. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 47: 1041-8. PMID 16741315 |
0.36 |
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| 2006 |
Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, Shah AR, LaRossa GN, Spinner ML, Klunk WE, Mathis CA, DeKosky ST, Morris JC, Holtzman DM. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Annals of Neurology. 59: 512-9. PMID 16372280 DOI: 10.1002/ana.20730 |
0.36 |
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| 2006 |
Vangveravong S, McElveen E, Taylor M, Xu J, Tu Z, Luedtke RR, Mach RH. Synthesis and characterization of selective dopamine D2 receptor antagonists. Bioorganic & Medicinal Chemistry. 14: 815-25. PMID 16288878 DOI: 10.1016/j.bmc.2005.09.008 |
0.36 |
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| 2005 |
Chu W, Zhang J, Zeng C, Rothfuss J, Tu Z, Chu Y, Reichert DE, Welch MJ, Mach RH. N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies. Journal of Medicinal Chemistry. 48: 7637-47. PMID 16302804 DOI: 10.1021/jm0506625 |
0.36 |
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| 2005 |
Xu J, Tu Z, Jones LA, Vangveravong S, Wheeler KT, Mach RH. [3H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]- 2-methoxy-5-methylbenzamide: A novel sigma-2 receptor probe European Journal of Pharmacology. 525: 8-17. PMID 16289030 DOI: 10.1016/j.ejphar.2005.09.063 |
0.36 |
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| 2005 |
Mach RH, Gage HD, Buchheimer N, Huang Y, Kuhner R, Wu L, Morton TE, Ehrenkaufer RL. N-[18F]4'-fluorobenzylpiperidin-4yl-(2-fluorophenyl) acetamide ([18F]FBFPA): a potential fluorine-18 labeled PET radiotracer for imaging sigma-1 receptors in the CNS. Synapse (New York, N.Y.). 58: 267-74. PMID 16206186 DOI: 10.1002/syn.20207 |
0.36 |
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| 2005 |
Tu Z, Chu W, Zhang J, Dence CS, Welch MJ, Mach RH. Synthesis and in vivo evaluation of [11C]PJ34, a potential radiotracer for imaging the role of PARP-1 in necrosis Nuclear Medicine and Biology. 32: 437-443. PMID 15982573 DOI: 10.1016/j.nucmedbio.2005.03.001 |
0.36 |
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| 2005 |
Tu Z, Dence CS, Ponde DE, Jones L, Wheeler KT, Welch MJ, Mach RH. Carbon-11 labeled sigma2 receptor ligands for imaging breast cancer. Nuclear Medicine and Biology. 32: 423-30. PMID 15982571 DOI: 10.1016/j.nucmedbio.2005.03.008 |
0.36 |
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| 2005 |
Chu W, Tu Z, McElveen E, Xu J, Taylor M, Luedtke RR, Mach RH. Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry. 13: 77-87. PMID 15582454 DOI: 10.1016/j.bmc.2004.09.054 |
0.36 |
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| 2004 |
Fahey FH, Gage HD, Buchheimer N, Smith HC, Harkness BA, Williams RC, Bounds MC, Mercier J, Robbins ME, Payne RM, Morton KA, Mach RH. Evaluation of the quantitative capability of a high-resolution positron emission tomography scanner for small animal imaging. Journal of Computer Assisted Tomography. 28: 842-8. PMID 15538162 DOI: 10.1097/00004728-200411000-00020 |
0.36 |
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| 2004 |
Dence CS, Herrero P, Schwarz SW, Mach RH, Gropler RJ, Welch MJ. Imaging myocardium enzymatic pathways with carbon-11 radiotracers Methods in Enzymology. 385: 286-315. PMID 15130745 DOI: 10.1016/S0076-6879(04)85016-X |
0.36 |
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| 2004 |
Clark PB, Gage HD, Brown-Proctor C, Buchheimer N, Calles-Escandon J, Mach RH, Morton KA. Neurofunctional imaging of the pancreas utilizing the cholinergic PET radioligand [18F]4-fluorobenzyltrozamicol European Journal of Nuclear Medicine and Molecular Imaging. 31: 258-260. PMID 15129709 DOI: 10.1007/s00259-003-1350-7 |
0.36 |
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| 2004 |
Mach RH, Huang Y, Freeman RA, Wu L, Vangveravong S, Luedtke RR. Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands. Bioorganic & Medicinal Chemistry Letters. 14: 195-202. PMID 14684327 DOI: 10.1016/j.bmcl.2003.09.083 |
0.36 |
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| 2003 |
Leudtke RR, Mach RH. Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychiatric disorders Current Pharmaceutical Design. 9: 643-671. PMID 12570797 DOI: 10.2174/1381612033391199 |
0.36 |
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| 2003 |
Mach RH, Huang Y, Freeman RA, Wu L, Blair S, Luedtke RR. Synthesis of 2-(5-bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1H-pyrrole analogues and their binding affinities for dopamine D2, D3, and D4 receptors. Bioorganic & Medicinal Chemistry. 11: 225-33. PMID 12470717 DOI: 10.1016/S0968-0896(02)00341-3 |
0.36 |
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| 2003 |
Mach RH, Vangveravong S, Huang Y, Yang B, Blair JB, Wu L. Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamate analogs as sigma-2 receptor ligands Medicinal Chemistry Research. 11: 380-398. |
0.36 |
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| 2002 |
Nader MA, Sinnott RS, Mach RH, Morgan D. Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist. Psychopharmacology. 163: 292-301. PMID 12373430 DOI: 10.1007/s00213-002-1202-3 |
0.36 |
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| 2002 |
Morgan D, Grant KA, Gage HD, Mach RH, Kaplan JR, Prioleau O, Nader SH, Buchheimer N, Ehrenkaufer RL, Nader MA. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nature Neuroscience. 5: 169-74. PMID 11802171 DOI: 10.1038/nn798 |
0.36 |
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| 2001 |
Huang Y, Hammond PS, Wu L, Mach RH. Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent σ1receptor ligands Journal of Medicinal Chemistry. 44: 4404-4415. PMID 11728186 DOI: 10.1021/jm010384j |
0.36 |
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| 2001 |
Huang Y, Luedtke RR, Freeman RA, Wu L, Mach RH. Synthesis of 2-(2,3-dimethoxyphenyl)-4-(aminomethyl)imidazole analogues and their binding affinities for dopamine D2 and D3 receptors Bioorganic and Medicinal Chemistry. 9: 3113-3122. PMID 11711286 DOI: 10.1016/S0968-0896(01)00175-4 |
0.36 |
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| 2001 |
Choi SR, Yang B, Plössl K, Chumpradit S, Wey SP, Acton PD, Wheeler K, Mach RH, Kung HF. Development of a Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent Nuclear Medicine and Biology. 28: 657-666. PMID 11518647 DOI: 10.1016/S0969-8051(01)00234-7 |
0.36 |
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| 2001 |
Mach RH, Huang Y, Buchheimer N, Kuhner R, Wu L, Morton TE, Wang LM, Ehrenkaufer RL, Wallen CA, Wheeler KT. [18F]N-4′-Fluorobenzyl-4-(3-bromophenyl) acetamide for imaging the sigma receptor status of tumors: Comparison with [18F]FDG and [125I]IUDR Nuclear Medicine and Biology. 28: 451-458. PMID 11395319 DOI: 10.1016/S0969-8051(01)00201-3 |
0.36 |
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| 2001 |
Huang Y, Luedtke RR, Freeman RA, Wu L, Mach RH. Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands Journal of Medicinal Chemistry. 44: 1815-1826. PMID 11356115 DOI: 10.1021/jm0100077 |
0.36 |
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| 2001 |
Gage HD, Gage JC, Tobin JR, Chiari A, Tong C, Xu Z, Mach RH, Efange SM, Ehrenkaufer RL, Eisenach JC. Morphine-induced spinal cholinergic activation: in vivo imaging with positron emission tomography. Pain. 91: 139-45. PMID 11240086 DOI: 10.1016/S0304-3959(00)00426-7 |
0.36 |
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| 2001 |
Voytko ML, Mach RH, Gage HD, Ehrenkaufer RL, Efange SM, Tobin JR. Cholinergic activity of aged rhesus monkeys revealed by positron emission tomography. Synapse (New York, N.Y.). 39: 95-100. PMID 11071714 DOI: 10.1002/1098-2396(20010101)39:1<95::AID-SYN12>3.0.CO;2-2 |
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| 2001 |
Mach RH, Wheeler KT, Blair S, Yang B, Day CS, Blair JB, Choi SR, Kung HF. Preparation of a technetium-99m SPECT agent for imaging the sigma-2 receptor status of solid tumors Journal of Labelled Compounds and Radiopharmaceuticals. 44: 899-908. DOI: 10.1002/jlcr.516 |
0.36 |
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| 2001 |
Mach RH, Yang B, Wu L, Kuhner RJ, Whirrett BR, West T. Synthesis and sigma receptor binding affinities of 8-azabicyclo[3.2.1]octan-3α-yl and 9-azabicyclo[3.3.1]nonan-3α-yl phenylcarbamates Medicinal Chemistry Research. 10: 339-355. |
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| 2000 |
Efange SMN, Von Hohenberg K, Khare AB, Tu Z, Mach RH, Parsons SM. Synthesis and biological characterization of stable and radioiodinated (±)-trans-2-hydroxy-3-P{4-(3-iodophenyl)piperidyl}-1,2,3,4-tetrahyd ronaphthalene (3′-IBVM) Nuclear Medicine and Biology. 27: 749-755. PMID 11150707 DOI: 10.1016/S0969-8051(00)00157-8 |
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| 2000 |
Gage HD, Voytko ML, Ehrenkaufer RL, Tobin JR, Efange SM, Mach RH. Reproducibility of repeated measures of cholinergic terminal density using. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 41: 2069-76. PMID 11138694 |
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| 2000 |
Luedtke RR, Freeman RA, Boundy VA, Martin MW, Huang Y, Mach RH. Characterization of 125I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptors Synapse. 38: 438-449. PMID 11044891 DOI: 10.1002/1098-2396(20001215)38:4<438::AID-SYN9>3.0.CO;2-5 |
0.36 |
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| 2000 |
Mach RH, Nader MA, Ehrenkaufer RL, Gage HD, Childers SR, Hodges LM, Hodges MM, Davies HM. Fluorine-18-labeled tropane analogs for PET imaging studies of the dopamine transporter. Synapse (New York, N.Y.). 37: 109-17. PMID 10881032 DOI: 10.1002/1098-2396(200008)37:2<109::AID-SYN5>3.0.CO;2-3 |
0.36 |
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| 2000 |
Wheeler KT, Wang LM, Wallen CA, Childers SR, Cline JM, Keng PC, Mach RH. Sigma-2 receptors as a biomarker of proliferation in solid tumours British Journal of Cancer. 82: 1223-1232. PMID 10735510 |
0.36 |
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| 1999 |
Nader MA, Green KL, Luedtke RR, Mach RH. The effects of benzamide analogues on cocaine self-administration in rhesus monkeys. Psychopharmacology. 147: 143-52. PMID 10591881 |
0.36 |
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| 1999 |
Khare AB, Langason RB, Parsons SM, Mach RH, Efange SMN. N-(3-iodophenyl)trozamicol (IPHT) and related inhibitors of vesicular acetylcholine transport: Synthesis and preliminary biological characterization Nuclear Medicine and Biology. 26: 609-617. PMID 10587098 DOI: 10.1016/S0969-8051(99)00013-X |
0.36 |
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| 1999 |
Al-Nabulsi I, Mach RH, Wang LM, Wallen CA, Keng PC, Sten K, Childers SR, Wheeler KT. Effect of ploidy, recruitment, environmental factors, and tamoxifen treatment on the expression of sigma-2 receptors in proliferating and quiescent tumour cells British Journal of Cancer. 81: 925-933. PMID 10576647 DOI: 10.1038/sj.bjc.6690789 |
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| 1999 |
Nader MA, Grant KA, Gage HD, Ehrenkaufer RL, Kaplan JR, Mach RH. PET imaging of dopamine D2 receptors with [18F]fluoroclebopride in monkeys: effects of isoflurane- and ketamine-induced anesthesia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 589-96. PMID 10481842 DOI: 10.1016/S0893-133X(98)00101-8 |
0.36 |
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| 1999 |
Efange SMN, Khare AB, Mach RH, Parsons SM. Hydroxylated decahydroquinolines as ligands for the vesicular acetylcholine transporter: Synthesis and biological evaluation Journal of Medicinal Chemistry. 42: 2862-2869. PMID 10425095 DOI: 10.1021/jm980560x |
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| 1999 |
Sinnott RS, Mach RH, Nader MA. Dopamine D2/D3 receptors modulate cocaine's reinforcing and discriminative stimulus effects in rhesus monkeys. Drug and Alcohol Dependence. 54: 97-110. PMID 10217549 DOI: 10.1016/S0376-8716(98)00162-8 |
0.36 |
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| 1999 |
Efange SM, Nader MA, Ehrenkaufer RL, Khare AB, Smith CR, Morton TE, Mach RH. (+)-p-([18F]fluorobenzyl)spirotrozamicol [(+)-[18F]spiro-FBT]: synthesis and biological evaluation of a high-affinity ligand for the vesicular acetylcholine transporter (VAChT). Nuclear Medicine and Biology. 26: 189-92. PMID 10100218 DOI: 10.1016/S0969-8051(98)00090-0 |
0.36 |
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| 1999 |
Mach RH, Wu L, West T, Whirrett BR, Childers SR. The analgesic tropane analogue (±)-SM 21 has a high affinity for σ2 receptors Life Sciences. 64: PL131-PL137. PMID 10096443 |
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| 1999 |
Gage HD, Gage JC, Chiari A, Xu ZM, Mach RH, Efange SM, Ehrenkaufer RL, Eisenach JC. In vivo imaging of the spinal cord cholinergic system with PET. Journal of Computer Assisted Tomography. 23: 25-33. PMID 10050803 DOI: 10.1097/00004728-199901000-00007 |
0.36 |
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| 1999 |
Yang B, Whirrett BR, Wu L, Wheeler KT, Childers SR, Mach RH. Azabicyclo[3.2.1]octan-3α-yl and azabicyclo[3.3.1]nonan-3α-yl carbamates as σ2-selective radiotracers Journal of Labelled Compounds and Radiopharmaceuticals. 42: S684-S686. |
0.36 |
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| 1999 |
Huang Y, Buchheimer N, Kuhner R, Wu L, Morton TE, Ehrenkaufer RL, Mach RH. [F-18] N-4'-fluorobenzyl-4-(2-fluorophenyl)acetamide for imaging sigma-1 receptors Journal of Labelled Compounds and Radiopharmaceuticals. 42. |
0.36 |
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| 1999 |
Mach RH, Nader MA, Ehrenkaufer RL, Childers SR, Hodges LM, Hodges MM, Davies HML. Fluorine-18 labeled tropane analogues for imaging the dopamine transporter: Synthesis, in vitro binding, and PET imaging studies in rhesus monkeys Journal of Labelled Compounds and Radiopharmaceuticals. 42: S39-S41. |
0.36 |
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| 1999 |
Hammond PS, Cheney JT, Johnston DE, Ehrenkaufer RL, Luedtke RR, Mach RH. Synthesis, in vitro dopamine D2 and D3 receptor binding and quantitative structure-activity studies on substituted 2,3-dimethoxy-N-(1- benzyl-4-piperidinyl)benzamides and related compounds Medicinal Chemistry Research. 9: 35-49. |
0.36 |
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| 1999 |
Mach RH, Hammond PS, Huang Y, Yang B, Xu Y, Cheney JT, Freeman R, Luedtke RR. Structure-activity relationship studies of N-(9-benzyl)-9- azabicyclo[3.3.1]nonan-3-β-yl benzamide analogues for dopamine D2 and D3 receptors Medicinal Chemistry Research. 9: 355-373. |
0.36 |
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| 1999 |
Mach RH, Huang Y, Buchheimer N, Kuhner R, Wu L, Morton TE, Wang LM, Ehrenkaufer RL, Wheeler KT. [F-18]-N-4'-fluorobenzyl-4-(3-bromophenyl)acetamide for imaging the sigma receptor status of tumors Journal of Labelled Compounds and Radiopharmaceuticals. 42. |
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| 1998 |
Huang Y, Hammond PS, Whirrett BR, Kuhner RJ, Wu L, Childers SR, Mach RH. Synthesis and quantitative structure-activity relationships of N-(1- benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective σ1 receptor ligands Journal of Medicinal Chemistry. 41: 2361-2370. PMID 9632369 DOI: 10.1021/jm980032l |
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| 1998 |
Grant KA, Shively CA, Nader MA, Ehrenkaufer RL, Line SW, Morton TE, Gage HD, Mach RH. Effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography. Synapse (New York, N.Y.). 29: 80-3. PMID 9552177 DOI: 10.1002/(SICI)1098-2396(199805)29:1<80::AID-SYN7>3.0.CO;2-7 |
0.36 |
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| 1998 |
Yang B, Johnston DE, Luedtke RR, Hammond PS, Mach RH. Synthesis and in vitro binding of N-alkyl-2,3- dimethoxy[3.3.1]azabicyclononane benzamides at dopamine D2 and D3 receptors Medicinal Chemistry Research. 8: 115-131. |
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| 1997 |
Efange SMN, Kamath AP, Khare AB, Kung MP, Mach RH, Parsons SM. N-hydroxyalkyl derivatives of 3β-phenyltropane and 1-methylspiro[1H- indoline-3,4'-piperidine]: Vesamicol analogues with affinity for monoamine transporters Journal of Medicinal Chemistry. 40: 3905-3914. PMID 9397171 DOI: 10.1021/jm970326r |
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| 1997 |
Mach RH, Nader MA, Ehrenkaufer RL, Line SW, Smith CR, Gage HD, Morton TE. Use of positron emission tomography to study the dynamics of psychostimulant-induced dopamine release. Pharmacology, Biochemistry, and Behavior. 57: 477-86. PMID 9218272 DOI: 10.1016/S0091-3057(96)00449-2 |
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| 1997 |
Mach RH, Voytko ML, Ehrenkaufer RL, Nader MA, Tobin JR, Efange SM, Parsons SM, Gage HD, Smith CR, Morton TE. Imaging of cholinergic terminals using the radiotracer [18F](+)-4-fluorobenzyltrozamicol: in vitro binding studies and positron emission tomography studies in nonhuman primates. Synapse (New York, N.Y.). 25: 368-80. PMID 9097396 DOI: 10.1002/(SICI)1098-2396(199704)25:4<368::AID-SYN8>3.0.CO;2-8 |
0.36 |
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| 1997 |
Shively CA, Grant KA, Ehrenkaufer RL, Mach RH, Nader MA. Social stress, depression, and brain dopamine in female cynomolgus monkeys. Annals of the New York Academy of Sciences. 807: 574-7. PMID 9071402 DOI: 10.1111/j.1749-6632.1997.tb51972.x |
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| 1997 |
Nader MA, Grant KA, Davies HM, Mach RH, Childers SR. The reinforcing and discriminative stimulus effects of the novel cocaine analog 2beta-propanoyl-3beta-(4-tolyl)-tropane in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 280: 541-50. PMID 9023262 |
0.36 |
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| 1997 |
Mach RH, Smith CR, Al-Nabulsi I, Whirrett BR, Childers SR, Wheeler KT. σ2 Receptors as potential biomarkers of proliferation in breast cancer Cancer Research. 57: 156-161. PMID 8988058 |
0.36 |
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| 1996 |
Mach RH, Nader MA, Ehrenkaufer RL, Line SW, Smith CR, Luedtke RR, Kung MP, Kung HF, Lyons D, Morton TE. Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly to dopamine D2 receptors: in vitro binding studies and positron emission tomography. Synapse (New York, N.Y.). 24: 322-33. PMID 10638823 DOI: 10.1002/(SICI)1098-2396(199612)24:4<322::AID-SYN2>3.0.CO;2-F |
0.36 |
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| 1996 |
Nader MA, Mach RH. Self-administration of the dopamine D3 agonist 7-OH-DPAT in rhesus monkeys is modified by prior cocaine exposure. Psychopharmacology. 125: 13-22. PMID 8724444 DOI: 10.1007/BF02247388 |
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| 1995 |
Mach RH, Ehrenkaufer RL, Greenberg JH, Shao L, Morton TE, Evora PH, Nowak PA, Luedtke RR, Cohen D, Reivich M. PET imaging studies of dopamine D2 receptors: comparison of [18F]N-methylspiperone and the benzamide analogues [18F]MABN and [18F]MBP in baboon brain. Synapse (New York, N.Y.). 19: 177-87. PMID 7784958 DOI: 10.1002/syn.890190305 |
0.36 |
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| 1995 |
Efange SMN, Mach RH, Smith CR, Khare AB, Foulon C, Akella SK, Childers SR, Parsons SM. Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor Biochemical Pharmacology. 49: 791-797. PMID 7702637 DOI: 10.1016/0006-2952(94)00541-S |
0.36 |
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| 1995 |
Mach RH, Smith CR, Childers SR. Ibogaine possesses a selective affinity for σ2 receptors Life Sciences. 57: PL57-PL62. PMID 7603301 DOI: 10.1016/0024-3205(95)00301-L |
0.36 |
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| 1995 |
Elder ST, Mach RH, Nowak PA, Moroney DA, Rao AV, Ehrenkaufer RLE. Esters of 6‐(4′‐fluorobenzylamino)‐β‐ carboline‐3‐carboxylic acid as potential benzodiazepine imaging agents for P.E.T Journal of Labelled Compounds and Radiopharmaceuticals. 36: 205-211. DOI: 10.1002/jlcr.2580360302 |
0.36 |
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| 1994 |
Efange SMN, Mach RH, Khare A, Michelson RH, Nowak PA, Evora PH. p-[18F]fluorobenzyltrozamicol ([18F]FBT): Molecular decomposition-reconstitution approach to vesamicol receptor radioligands for positron emission tomography Applied Radiation and Isotopes. 45: 465-472. PMID 8186771 DOI: 10.1016/0969-8043(94)90113-9 |
0.36 |
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| 1994 |
Mach RH, Morton TE, Ehrenkaufer RLE. A safety interlocked remote system for the synthesis and reactions of [18F]fluorobenzyl iodide Journal of Labelled Compounds and Radiopharmaceuticals. 35: 157-159. |
0.36 |
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| 1993 |
Mach RH, Nowak PA, Moroney DA, Morton TE, Jackson JR, Ehrenkaufer RL. Synthesis and in vivo evaluation of [18F]-N-(p-nitrobenzyl)spiperone ([18F]PNBS) in rats. Nuclear Medicine and Biology. 20: 269-78. PMID 8485486 DOI: 10.1016/0969-8051(93)90048-Y |
0.36 |
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| 1993 |
Mach RH, Elder ST, Morton TE, Nowak PA, Evora PH, Scripko JG, Luedtke RR, Unsworth CD, Filtz T, Rao AV, Molinoff PB, Ehrenkaufer RLE. The use of [18F]4-fluorobenzyl iodide (FBI) in PET radiotracer synthesis: Model alkylation studies and its application in the design of dopamine D1 and D2 receptor-based imaging agents Nuclear Medicine and Biology. 20: 777-794. PMID 8401379 DOI: 10.1016/0969-8051(93)90165-Q |
0.36 |
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| 1993 |
Mach RH, Luedtke RR, Unsworth CD, Boundy VA, Nowak PA, Scripko JG, Elder ST, Jackson JR, Hoffman PL, Evora PH. 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. Journal of Medicinal Chemistry. 36: 3707-20. PMID 8246241 |
0.36 |
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| 1993 |
Efange SMN, Mach RH. In vivo detection of receptors J.Clin.Immunoassay. 16: 311-329. |
0.36 |
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| 1992 |
Mach RH, Jackson JR, Luedtke RR, Ivins KJ, Molinoff PB, Ehrenkaufer RL. Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. Journal of Medicinal Chemistry. 35: 423-30. PMID 1531364 |
0.36 |
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| 1992 |
Smith RD, Mach RH, Morton TE, Dembowski BS, Ehrenkaufer RL. Optimization of [11C]CO2 trapping efficiencies from nitrogen gas streams International Journal of Radiation Applications and Instrumentation. Part. 43: 466-468. PMID 1318876 DOI: 10.1016/0883-2889(92)90123-V |
0.36 |
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| 1991 |
Mach RH, Kung HF, Jungwiwattanaporn P, Guo YZ. Synthesis and biodistribution of a new class of 99mTc-labeled fatty acid analogs for myocardial imaging. International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology. 18: 215-26. PMID 2026498 DOI: 10.1016/0883-2897(91)90082-V |
0.36 |
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| 1991 |
Mach RH, Kung HF, Jungwiwattanaporn P, Guo YZ. Synthesis and biodistribution of a new class of 99mTc-labeled fatty acid analogs for myocardial imaging International Journal of Radiation Applications and Instrumentation.. 18: 215-226. DOI: 10.1016/0883-2897(91)90082-V |
0.36 |
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| 1991 |
Mach RH, Kung HF. Mass spectral analysis of N2S2 ligands used for complexation of Tc-99m Journal of Labelled Compounds and Radiopharmaceuticals. 30. |
0.36 |
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| 1991 |
Mach RH, Scripko JG, Ehrenkaufer RL, Morton TE. The use of [F-18]4-fluorobenzyl iodide as a prosthetic group of introducing F-18 into pharmacologically active molecules: N-Alkylation of amines and amides Journal of Labelled Compounds and Radiopharmaceuticals. 30. |
0.36 |
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| 1991 |
Smith RD, Mach RH, Morton TE, Dembowski BS, Ehrenkaufer RLE. Optimization of carbon-11 carbon dioxide trapping from nitrogen gas streams Journal of Labelled Compounds and Radiopharmaceuticals. 30: 158. |
0.36 |
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| 1990 |
Luedtke RR, Bush M, Mach RH, Ehrenkaufer RE, Kung HF, Molinoff PB. Antibodies with high affinity for spiroperidol--II. Cross reactivity with iodobenzamide and domperidone. Molecular Immunology. 27: 667-77. PMID 2395438 DOI: 10.1016/0161-5890(90)90010-W |
0.36 |
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| 1990 |
Anderson WK, Mach RH. Synthesis and chemical reactivity of c‐5 substituted 6,7‐bis‐(hydroxymethyl)‐1H‐pyrrolizine biscarbamate tumor inhibitors Journal of Heterocyclic Chemistry. 27: 1025-1030. DOI: 10.1002/jhet.5570270440 |
0.36 |
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| 1989 |
Mach RH, Kung HF, Guo YZ, Yu CC, Subramanyam V, Calabrese JC. Synthesis, characterization and biodistribution of neutral and lipid-soluble 99mTc-PAT-HM and 99mTc-TMR for brain imaging Nuclear Medicine and Biology. 16: 829-837. PMID 2621118 DOI: 10.1016/0883-2897(89)90168-2 |
0.36 |
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| 1989 |
Mach RH, Kung HF, Jungwiwattanaporn P, Guo YZ. A new synthesis of bis-aminoethanethiol (bat) chelating agents containing a gamma carboxylate Tetrahedron Letters. 30: 4069-4072. DOI: 10.1016/S0040-4039(00)99324-9 |
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| 1988 |
Kung HF, Billings JJ, Guo YZ, Mach RH. Comparison of in vivo d-2 dopamine receptor binding of IBZM and NMSP in rat brain Nuclear Medicine and Biology. 15: 203-208. PMID 2966783 DOI: 10.1016/0883-2897(88)90089-X |
0.36 |
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| 1988 |
Kung HF, Kasliwal R, Pan S, Kung MP, Mach RH, Guo YZ. Dopamine D-2 receptor imaging radiopharmaceuticals: Synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide Journal of Medicinal Chemistry. 31: 1039-1043. PMID 2966245 |
0.36 |
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| 1988 |
Kung HF, Guo YZ, Billings J, Xu X, Mach RH, Blau M, Ackerhalt RE. Preparation and biodistribution of [125I]IBZM: A potential CNS D-2 dopamine receptor imaging agent International Journal of Radiation Applications and Instrumentation.. 15. DOI: 10.1016/0883-2897(88)90088-8 |
0.36 |
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| 1987 |
Anderson WK, Mach RH. Synthesis, chemical reactivity, and antileukemic activity of 5-substituted 6,7-bis(hydroxymethyl)pyrrolo[1,2-c]thiazole biscarbamates and the corresponding sulfoxides and sulfones Journal of Medicinal Chemistry. 30: 2109-2115. PMID 3669018 |
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| 1986 |
Anderson WK, Mach RH. Selective reduction of carboxylic acid esters in the presence of a five-membered cyclic sulfone Synthetic Communications. 16: 911-915. DOI: 10.1080/00397918608077293 |
0.36 |
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| 1986 |
Mach RH, Kung HF, Xu XJ. Synthesis and biodistribution of Tc-99m BAT-PDA: A potential heart imaging agent for SPECT Journal of Labelled Compounds and Radiopharmaceuticals. 23: 1138-1140. |
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