Richard G. Brennan - Publications

Affiliations: 
Biochemistry Duke University, Durham, NC 
Area:
Biochemistry

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Schumacher MA, Balani P, Min J, Chinnam NB, Hansen S, Vulić M, Lewis K, Brennan RG. HipBA-promoter structures reveal the basis of heritable multidrug tolerance. Nature. 524: 59-64. PMID 26222023 DOI: 10.1038/nature14662  1
2015 Cuthbert BJ, Brennan RG, Schumacher MA. Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA). Plos One. 10: e0128225. PMID 26121147 DOI: 10.1371/journal.pone.0128225  1
2015 Schindler BD, Seo SM, Birukou I, Brennan RG, Kaatz GW. Mutations within the mepA operator affect binding of the MepR regulatory protein and its induction by MepA substrates in Staphylococcus aureus. Journal of Bacteriology. 197: 1104-14. PMID 25583977 DOI: 10.1128/JB.02558-14  1
2015 Reniere ML, Whiteley AT, Hamilton KL, John SM, Lauer P, Brennan RG, Portnoy DA. Glutathione activates virulence gene expression of an intracellular pathogen. Nature. 517: 170-3. PMID 25567281 DOI: 10.1038/nature14029  1
2014 Tschowri N, Schumacher MA, Schlimpert S, Chinnam NB, Findlay KC, Brennan RG, Buttner MJ. Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. Cell. 158: 1136-47. PMID 25171413 DOI: 10.1016/j.cell.2014.07.022  1
2014 Kovach AR, Hoff KE, Canty JT, Orans J, Brennan RG. Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes. Rna (New York, N.Y.). 20: 1548-59. PMID 25150227 DOI: 10.1261/rna.044032.113  1
2014 Birukou I, Seo SM, Schindler BD, Kaatz GW, Brennan RG. Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR. Nucleic Acids Research. 42: 2774-88. PMID 24293644 DOI: 10.1093/nar/gkt1215  1
2014 Robinson KE, Orans J, Kovach AR, Link TM, Brennan RG. Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching. Nucleic Acids Research. 42: 2736-49. PMID 24288369 DOI: 10.1093/nar/gkt1171  1
2013 Birukou I, Tonthat NK, Seo SM, Schindler BD, Kaatz GW, Brennan RG. The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus. Mbio. 4: e00528-13. PMID 23982071 DOI: 10.1128/mBio.00528-13  1
2013 Schindler BD, Seo SM, Jacinto PL, Kumaraswami M, Birukou I, Brennan RG, Kaatz GW. Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene. Journal of Bacteriology. 195: 3651-62. PMID 23749979 DOI: 10.1128/JB.00565-13  1
2013 Rajagopalan S, Teter SJ, Zwart PH, Brennan RG, Phillips KJ, Kiley PJ. Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity. Nature Structural & Molecular Biology. 20: 740-7. PMID 23644595 DOI: 10.1038/nsmb.2568  1
2013 Xie TX, Zhou G, Zhao M, Sano D, Jasser SA, Brennan RG, Myers JN. Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells. The Laryngoscope. 123: 1416-23. PMID 23625637 DOI: 10.1002/lary.23846  1
2012 Schumacher MA, Min J, Link TM, Guan Z, Xu W, Ahn YH, Soderblom EJ, Kurie JM, Evdokimov A, Moseley MA, Lewis K, Brennan RG. Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance. Cell Reports. 2: 518-25. PMID 22999936 DOI: 10.1016/j.celrep.2012.08.013  1
2012 Horstmann N, Orans J, Valentin-Hansen P, Shelburne SA, Brennan RG. Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract. Nucleic Acids Research. 40: 11023-35. PMID 22965117 DOI: 10.1093/nar/gks809  1
2012 Hansen S, Vulić M, Min J, Yen TJ, Schumacher MA, Brennan RG, Lewis K. Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis. Plos One. 7: e39185. PMID 22720069 DOI: 10.1371/journal.pone.0039185  1
2012 Amato AA, Rajagopalan S, Lin JZ, Carvalho BM, Figueira AC, Lu J, Ayers SD, Mottin M, Silveira RL, Souza PC, Mourão RH, Saad MJ, Togashi M, Simeoni LA, Abdalla DS, ... ... Brennan RG, et al. GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. The Journal of Biological Chemistry. 287: 28169-79. PMID 22584573 DOI: 10.1074/jbc.M111.332106  1
2011 Horstmann N, Sahasrabhojane P, Suber B, Kumaraswami M, Olsen RJ, Flores A, Musser JM, Brennan RG, Shelburne SA. Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. Plos Pathogens. 7: e1002311. PMID 22028655 DOI: 10.1371/journal.ppat.1002311  1
2011 Le TB, Schumacher MA, Lawson DM, Brennan RG, Buttner MJ. The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding. Nucleic Acids Research. 39: 9433-47. PMID 21835774 DOI: 10.1093/nar/gkr640  1
2011 Shelburne SA, Sahasrobhajane P, Suber B, Keith DB, Davenport MT, Horstmann N, Kumaraswami M, Olsen RJ, Brennan RG, Musser JM. Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein. Molecular Microbiology. 81: 500-14. PMID 21645132 DOI: 10.1111/j.1365-2958.2011.07708.x  1
2011 Peters KM, Brooks BE, Schumacher MA, Skurray RA, Brennan RG, Brown MH. A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity. Plos One. 6: e15974. PMID 21264225 DOI: 10.1371/journal.pone.0015974  1
2011 Schumacher MA, Sprehe M, Bartholomae M, Hillen W, Brennan RG. Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. Nucleic Acids Research. 39: 2931-42. PMID 21106498 DOI: 10.1093/nar/gkq1177  1
2010 Cho K, Vaught TG, Ji H, Gu D, Papasakelariou-Yared C, Horstmann N, Jennings JM, Lee M, Sevilla LM, Kloc M, Reynolds AB, Watt FM, Brennan RG, Kowalczyk AP, McCrea PD. Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. Journal of Cell Science. 123: 4128-44. PMID 21062899 DOI: 10.1242/jcs.072041  1
2010 Olsen AS, Møller-Jensen J, Brennan RG, Valentin-Hansen P. C-terminally truncated derivatives of Escherichia coli Hfq are proficient in riboregulation. Journal of Molecular Biology. 404: 173-82. PMID 20888338 DOI: 10.1016/j.jmb.2010.09.038  1
2010 Shelburne SA, Olsen RJ, Suber B, Sahasrabhojane P, Sumby P, Brennan RG, Musser JM. A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection. Plos Pathogens. 6: e1000817. PMID 20333240 DOI: 10.1371/journal.ppat.1000817  1
2010 Kumaraswami M, Newberry KJ, Brennan RG. Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR. Journal of Molecular Biology. 398: 264-75. PMID 20230832 DOI: 10.1016/j.jmb.2010.03.011  1
2010 Nakano MM, Lin A, Zuber CS, Newberry KJ, Brennan RG, Zuber P. Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit. Plos One. 5: e8664. PMID 20084284 DOI: 10.1371/journal.pone.0008664  1
2009 Stoll KE, Draper WE, Kliegman JI, Golynskiy MV, Brew-Appiah RA, Phillips RK, Brown HK, Breyer WA, Jakubovics NS, Jenkinson HF, Brennan RG, Cohen SM, Glasfeld A. Characterization and structure of the manganese-responsive transcriptional regulator ScaR. Biochemistry. 48: 10308-20. PMID 19795834 DOI: 10.1021/bi900980g  1
2009 Schumacher MA, Piro KM, Xu W, Hansen S, Lewis K, Brennan RG. Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science (New York, N.Y.). 323: 396-401. PMID 19150849 DOI: 10.1126/science.1163806  1
2009 Kumaraswami M, Schuman JT, Seo SM, Kaatz GW, Brennan RG. Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA. Nucleic Acids Research. 37: 1211-24. PMID 19129225 DOI: 10.1093/nar/gkn1046  1
2009 Hassan KA, Xu Z, Watkins RE, Brennan RG, Skurray RA, Brown MH. Optimized production and analysis of the staphylococcal multidrug efflux protein QacA. Protein Expression and Purification. 64: 118-24. PMID 19073264 DOI: 10.1016/j.pep.2008.11.009  1
2009 Shelburne SA, Keith D, Horstmann N, Sumby P, Davenport MT, Graviss EA, Brennan RG, Musser JM. A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 5, (1698-1703) DOI: 10.1073/pnas.0711767105) Proceedings of the National Academy of Sciences of the United States of America. 106: 8790. DOI: 10.1073/pnas.0903221106  1
2008 Newberry KJ, Huffman JL, Miller MC, Vazquez-Laslop N, Neyfakh AA, Brennan RG. Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion. The Journal of Biological Chemistry. 283: 26795-804. PMID 18658145 DOI: 10.1074/jbc.M804191200  1
2008 Peters KM, Schuman JT, Skurray RA, Brown MH, Brennan RG, Schumacher MA. QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization. Biochemistry. 47: 8122-9. PMID 18616285 DOI: 10.1021/bi8008246  1
2008 Shelburne SA, Keith DB, Davenport MT, Horstmann N, Brennan RG, Musser JM. Molecular characterization of group A Streptococcus maltodextrin catabolism and its role in pharyngitis. Molecular Microbiology. 69: 436-52. PMID 18485073 DOI: 10.1111/j.1365-2958.2008.06290.x  1
2008 Shelburne SA, Keith D, Horstmann N, Sumby P, Davenport MT, Graviss EA, Brennan RG, Musser JM. A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus. Proceedings of the National Academy of Sciences of the United States of America. 105: 1698-703. PMID 18230719 DOI: 10.1073/pnas.0711767105  1
2008 Amen M, Espinoza HM, Cox C, Liang X, Wang J, Link TM, Brennan RG, Martin JF, Amendt BA. Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling. Nucleic Acids Research. 36: 462-76. PMID 18045789 DOI: 10.1093/nar/gkm1047  1
2007 Newberry KJ, Fuangthong M, Panmanee W, Mongkolsuk S, Brennan RG. Structural mechanism of organic hydroperoxide induction of the transcription regulator OhrR. Molecular Cell. 28: 652-64. PMID 18042459 DOI: 10.1016/j.molcel.2007.09.016  1
2007 Brooks BE, Piro KM, Brennan RG. Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions. Journal of the American Chemical Society. 129: 8389-95. PMID 17567017 DOI: 10.1021/ja072576v  1
2007 Brennan RG, Link TM. Hfq structure, function and ligand binding. Current Opinion in Microbiology. 10: 125-33. PMID 17395525 DOI: 10.1016/j.mib.2007.03.015  1
2007 Schumacher MA, Seidel G, Hillen W, Brennan RG. Structural mechanism for the fine-tuning of CcpA function by the small molecule effectors glucose 6-phosphate and fructose 1,6-bisphosphate. Journal of Molecular Biology. 368: 1042-50. PMID 17376479 DOI: 10.1016/j.jmb.2007.02.054  1
2007 DeWitt MA, Kliegman JI, Helmann JD, Brennan RG, Farrens DL, Glasfeld A. The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state. Journal of Molecular Biology. 365: 1257-65. PMID 17118401 DOI: 10.1016/j.jmb.2006.10.080  1
2006 Mattison K, Wilbur JS, So M, Brennan RG. Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. The Journal of Biological Chemistry. 281: 37942-51. PMID 16982615 DOI: 10.1074/jbc.M605198200  1
2006 Kliegman JI, Griner SL, Helmann JD, Brennan RG, Glasfeld A. Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis. Biochemistry. 45: 3493-505. PMID 16533030 DOI: 10.1021/bi0524215  1
2006 Schumacher MA, Seidel G, Hillen W, Brennan RG. Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. The Journal of Biological Chemistry. 281: 6793-800. PMID 16316990 DOI: 10.1074/jbc.M509977200  1
2005 Hong M, Fuangthong M, Helmann JD, Brennan RG. Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family. Molecular Cell. 20: 131-41. PMID 16209951 DOI: 10.1016/j.molcel.2005.09.013  1
2005 Wilbur JS, Chivers PT, Mattison K, Potter L, Brennan RG, So M. Neisseria gonorrhoeae FitA interacts with FitB to bind DNA through its ribbon-helix-helix motif. Biochemistry. 44: 12515-24. PMID 16156663 DOI: 10.1021/bi0511080  1
2005 Hoffmann KM, Williams D, Shafer WM, Brennan RG. Characterization of the multiple transferable resistance repressor, MtrR, from Neisseria gonorrhoeae. Journal of Bacteriology. 187: 5008-12. PMID 15995218 DOI: 10.1128/JB.187.14.5008-5012.2005  1
2004 Schumacher MA, Allen GS, Diel M, Seidel G, Hillen W, Brennan RG. Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. Cell. 118: 731-41. PMID 15369672 DOI: 10.1016/j.cell.2004.08.027  1
2004 Schumacher MA, Miller MC, Brennan RG. Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein. The Embo Journal. 23: 2923-30. PMID 15257299 DOI: 10.1038/sj.emboj.7600288  1
2004 Newberry KJ, Brennan RG. The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. The Journal of Biological Chemistry. 279: 20356-62. PMID 14985361 DOI: 10.1074/jbc.M400960200  1
2004 Murray DS, Schumacher MA, Brennan RG. Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. The Journal of Biological Chemistry. 279: 14365-71. PMID 14726520 DOI: 10.1074/jbc.M313870200  1
2003 Glasfeld A, Guedon E, Helmann JD, Brennan RG. Structure of the manganese-bound manganese transport regulator of Bacillus subtilis. Nature Structural Biology. 10: 652-7. PMID 12847518 DOI: 10.1038/nsb951  1
2003 Schumacher MA, Brennan RG. Deciphering the molecular basis of multidrug recognition: crystal structures of the Staphylococcus aureus multidrug binding transcription regulator QacR. Research in Microbiology. 154: 69-77. PMID 12648720 DOI: 10.1016/S0923-2508(02)00013-X  1
2003 Allen GS, Steinhauer K, Hillen W, Stülke J, Brennan RG. Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae Journal of Molecular Biology. 326: 1203-1217. PMID 12589763 DOI: 10.1016/S0022-2836(02)01378-5  1
2002 Godsey MH, Zheleznova Heldwein EE, Brennan RG. Structural biology of bacterial multidrug resistance gene regulators. The Journal of Biological Chemistry. 277: 40169-72. PMID 12186881 DOI: 10.1074/jbc.R200018200  1
2002 Schumacher MA, Brennan RG. Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors. Molecular Microbiology. 45: 885-93. PMID 12180910 DOI: 10.1046/j.1365-2958.2002.03039.x  1
2002 Schumacher MA, Pearson RF, Møller T, Valentin-Hansen P, Brennan RG. Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein. The Embo Journal. 21: 3546-56. PMID 12093755 DOI: 10.1093/emboj/cdf322  1
2002 Bashor C, Denu JM, Brennan RG, Ullman B. Kinetic mechanism of adenine phosphoribosyltransferase from Leishmania donovani. Biochemistry. 41: 4020-31. PMID 11900545 DOI: 10.1021/bi0158730  1
2002 Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG. Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR. The Embo Journal. 21: 1210-8. PMID 11867549 DOI: 10.1093/emboj/21.5.1210  1
2002 Steinhauer K, Allen GS, Hillen W, Stülke J, Brennan RG. Crystallization, preliminary X-ray analysis and biophysical characterization of HPr kinase/phosphatase of Mycoplasma pneumoniae Acta Crystallographica Section D: Biological Crystallography. 58: 515-518. PMID 11856840 DOI: 10.1107/S090744490102145X  1
2002 Huffman JL, Brennan RG. Prokaryotic transcription regulators: more than just the helix-turn-helix motif. Current Opinion in Structural Biology. 12: 98-106. PMID 11839496 DOI: 10.1016/S0959-440X(02)00295-6  1
2002 Møller T, Franch T, Højrup P, Keene DR, Bächinger HP, Brennan RG, Valentin-Hansen P. Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. Molecular Cell. 9: 23-30. PMID 11804583 DOI: 10.1016/S1097-2765(01)00436-1  1
2002 Huffman JL, Lu F, Zalkin H, Brennan RG. Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor. Biochemistry. 41: 511-20. PMID 11781089 DOI: 10.1021/bi0156660  1
2002 Schumacher MA, Bashor CJ, Song MH, Otsu K, Zhu S, Parry RJ, Ullman B, Brennan RG. The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 99: 78-83. PMID 11773618 DOI: 10.1073/pnas.012399599  1
2001 Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG. Structural mechanisms of QacR induction and multidrug recognition. Science (New York, N.Y.). 294: 2158-63. PMID 11739955 DOI: 10.1126/science.1066020  1
2001 Grkovic S, Brown MH, Schumacher MA, Brennan RG, Skurray RA. The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers. Journal of Bacteriology. 183: 7102-9. PMID 11717268 DOI: 10.1128/JB.183.24.7102-7109.2001  1
2001 Godsey MH, Baranova NN, Neyfakh AA, Brennan RG. Crystal structure of MtaN, a global multidrug transporter gene activator. The Journal of Biological Chemistry. 276: 47178-84. PMID 11581256 DOI: 10.1074/jbc.M105819200  1
2001 Huffman JL, Mokashi A, Bächinger HP, Brennan RG. The basic helix-loop-helix domain of the aryl hydrocarbon receptor nuclear transporter (ARNT) can oligomerize and bind E-box DNA specifically. The Journal of Biological Chemistry. 276: 40537-44. PMID 11502749 DOI: 10.1074/jbc.M105675200  1
2001 Zheleznova Heldwein EE, Brennan RG. Crystal structure of the transcription activator BmrR bound to DNA and a drug Nature. 409: 378-382. PMID 11201751 DOI: 10.1038/35053138  1
2001 Schumacher MA, Hurlburt BK, Brennan RG. Crystal structures of SarA, a pleiotropic regulator of virulence genes in S. aureus Nature. 409: 215-219. PMID 11196648 DOI: 10.1038/35051623  1
2001 Craig JC, Schumacher MA, Mansoor SE, Farrens DL, Brennan RG, Goodman RH. Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties. The Journal of Biological Chemistry. 276: 11719-28. PMID 11134034 DOI: 10.1074/jbc.M010263200  1
2001 Brennan RG. Introduction: Multidrug resistance Seminars in Cell and Developmental Biology. 12: 201-204. DOI: 10.1006/scdb.2000.0245  1
2000 Godsey MH, Baranova NN, Neyfakh AA, Brennan RG. Crystallization and preliminary X-ray diffraction studies on the DNA-binding domain of the multidrug transporter activation protein (MtaN) from Bacillus subtilis. Acta Crystallographica. Section D, Biological Crystallography. 56: 1456-8. PMID 11053850 DOI: 10.1107/S0907444900010295  1
2000 Zheleznova EE, Crosa JH, Brennan RG. Characterization of the DNA- and metal-binding properties of Vibrio anguillarum Fur reveals conservation of a structural Zn2+ ion Journal of Bacteriology. 182: 6264-6267. PMID 11029454 DOI: 10.1128/JB.182.21.6264-6267.2000  1
2000 Vazquez-Laslop N, Zheleznovat EE, Markham PN, Brennan RG, Neyfakh AA. Recognition of multiple drugs by a single protein: A trivial solution of an old paradox Biochemical Society Transactions. 28: 517-520. PMID 10961951  1
2000 Schumacher MA, Goodman RH, Brennan RG. The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding. The Journal of Biological Chemistry. 275: 35242-7. PMID 10952992 DOI: 10.1074/jbc.M007293200  1
2000 Brown M, Schumacher MA, Wiens GD, Brennan RG, Rittenberg MB. The structural basis of repertoire shift in an immune response to phosphocholine Journal of Experimental Medicine. 191: 2101-2111. PMID 10859335 DOI: 10.1084/jem.191.12.2101  1
2000 Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG. Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. Journal of Molecular Biology. 298: 875-93. PMID 10801355 DOI: 10.1006/jmbi.2000.3753  1
2000 Cardinaux JR, Notis JC, Zhang Q, Vo N, Craig JC, Fass DM, Brennan RG, Goodman RH. Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. Molecular and Cellular Biology. 20: 1546-52. PMID 10669732 DOI: 10.1128/MCB.20.5.1546-1552.2000  1
2000 Schumacher MA, Scott DM, Mathews II, Ealick SE, Roos DS, Ullman B, Brennan RG. Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. Journal of Molecular Biology. 296: 549-67. PMID 10669608 DOI: 10.1006/jmbi.1999.3474  1
2000 Zheleznova EE, Markham P, Edgar R, Bibi E, Neyfakh AA, Brennan RG. A structure-based mechanism for drug binding by multidrug transporters Trends in Biochemical Sciences. 25: 39-43. PMID 10664577 DOI: 10.1016/S0968-0004(99)01514-5  1
1999 Glasfeld A, Koehler AN, Schumacher MA, Brennan RG. The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. Journal of Molecular Biology. 291: 347-61. PMID 10438625 DOI: 10.1006/jmbi.1999.2946  1
1999 Rechtin TM, Gillaspy AF, Schumacher MA, Brennan RG, Smeltzer MS, Hurlburt BK. Characterization of the SarA virulence gene regulator of staphylococcus aureus Molecular Microbiology. 33: 307-316. PMID 10411747 DOI: 10.1046/j.1365-2958.1999.01474.x  1
1999 Phillips CL, Ullman B, Brennan RG, Hill CP. Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. The Embo Journal. 18: 3533-45. PMID 10393170 DOI: 10.1093/emboj/18.13.3533  1
1999 Zheleznova EE, Markham PN, Neyfakh AA, Brennan RG. Structural basis of multidrug recognition by BMRR, a transcription activator of a multidrug transporter Cell. 96: 353-362. PMID 10025401 DOI: 10.1016/S0092-8674(00)80548-6  1
1998 Lu F, Brennan RG, Zalkin H. Escherichia coli purine repressor: Key residues for the allosteric transition between active and inactive conformations and for interdomain signaling Biochemistry. 37: 15680-15690. PMID 9843372 DOI: 10.1021/bi981617k  1
1998 Lundblad JR, Kwok RP, Laurance ME, Huang MS, Richards JP, Brennan RG, Goodman RH. The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove. The Journal of Biological Chemistry. 273: 19251-9. PMID 9668114 DOI: 10.1074/jbc.273.30.19251  1
1998 Schumacher MA, Carter D, Scott DM, Roos DS, Ullman B, Brennan RG. Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. The Embo Journal. 17: 3219-32. PMID 9628859 DOI: 10.1093/emboj/17.12.3219  1
1998 Arvidson DN, Lu F, Faber C, Zalkin H, Brennan RG. The structure of PurR mutant L54M shows an alternative to DNA kinking Nature Structural Biology. 5: 436-441. PMID 9628480 DOI: 10.1038/nsb0698-436  1
1998 Lu F, Schumacher MA, Arvidson DN, Haldimann A, Wanner BL, Zalkin H, Brennan RG. Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190 Biochemistry. 37: 971-982. PMID 9454587 DOI: 10.1021/bi971942s  1
1997 Zheleznova EE, Markham PN, Neyfakh AA, Brennan RG. Preliminary structural studies on the multi-ligand-binding domain of the transcription activator, BmrR, from Bacillus subtilis Protein Science. 6: 2465-2468. PMID 9385651  1
1997 Schumacher MA, Glasfeld A, Zalkin H, Brennan RG. The x-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water- mediated hydrogen bond to corepressor specificity and binding affinity Journal of Biological Chemistry. 272: 22648-22653. PMID 9278422 DOI: 10.1074/jbc.272.36.22648  1
1997 Schumacher MA, Zheleznova EE, Poundstone KS, Kluger R, Jones RT, Brennan RG. Allosteric intermediates indicate R2 is the liganded hemoglobin end state. Proceedings of the National Academy of Sciences of the United States of America. 94: 7841-4. PMID 9223274 DOI: 10.1073/pnas.94.15.7841  1
1996 Phillips CL, Ullman B, Brennan RG. Crystallization of the purine salvage enzyme adenine phosphoribosyltransferase Proteins: Structure, Function and Genetics. 25: 510-513. PMID 8865346 DOI: 10.1002/(SICI)1097-0134(199608)25:4<510::AID-PROT11>3.0.CO;2-K  1
1996 Schumacher MA, Carter D, Roos DS, Ullman B, Brennan RG. Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop Nature Structural Biology. 3: 881-887. PMID 8836106 DOI: 10.1038/nsb1096-881  1
1996 Richards JP, Bächinger HP, Goodman RH, Brennan RG. Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB. The Journal of Biological Chemistry. 271: 13716-23. PMID 8662719 DOI: 10.1074/jbc.271.23.13716  1
1996 Lewis M, Chang G, Horton NC, Kercher MA, Pace HC, Schumacher MA, Brennan RG, Lu P. Crystal structure of the lactose operon represser and its complexes with DNA and inducer Science. 271: 1247-1254. PMID 8638105  1
1996 Glasfeld A, Schumacher MA, Choi KY, Zalkin H, Brennan RG. A positively charged residue bound in the minor groove does not alter the bending of a DNA duplex Journal of the American Chemical Society. 118: 13073-13074. DOI: 10.1021/ja962416b  1
1995 Nagadoi A, Nakazawa K, Morikawa S, Nakamura H, Sampei G, Mizobuchi K, Yamamoto H, Schumacher MA, Brennan RG, Nishimura Y. Conformational changes of purine repressor DNA-binding domain upon complexation with DNA Nucleic Acids Symposium Series. 63-64. PMID 8841553  1
1995 Nagadoi A, Morikawa S, Nakamura H, Enari M, Kobayashi K, Yamamoto H, Sampei G, Mizobuchi K, Schumacher MA, Brennan RG, Nishimura Y. Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain Structure. 3: 1217-1224. PMID 8591032 DOI: 10.1016/S0969-2126(01)00257-X  1
1995 Schumacher MA, Dixon MM, Kluger R, Jones RT, Brennan RG. Allosteric transition intermediates modelled by crosslinked haemoglobins. Nature. 375: 84-7. PMID 7723849 DOI: 10.1038/375084a0  1
1995 Schumacher MA, Choi KY, Lu F, Zalkin H, Brennan RG. Mechanism of corepressor-mediated specific DNA binding by the purine repressor Cell. 83: 147-155. PMID 7553867 DOI: 10.1016/0092-8674(95)90243-0  1
1994 Schumacher MA, Choi KY, Zalkin H, Brennan RG. Crystallization and preliminary X-ray analysis of an Escherichia coli purine repressor-hypoxanthine-DNA complex Journal of Molecular Biology. 242: 302-305. PMID 8089849  1
1994 Schumacher MA, Choi KY, Zalkin H, Brennan RG. Crystal structure of lacl member, PurR, bound to DNA: Minor groove binding by α helices Science. 266: 763-770. PMID 7973627  1
1994 Brickey DA, Bann JG, Fong YL, Perrino L, Brennan RG, Soderling TR. Mutational analysis of the autoinhibitory domain of calmodulin kinase II. The Journal of Biological Chemistry. 269: 29047-54. PMID 7961870  1
1994 Loriaux MM, Brennan RG, Goodman RH. Modulatory function of CREB.CREM alpha heterodimers depends upon CREM alpha phosphorylation. The Journal of Biological Chemistry. 269: 28839-43. PMID 7961842  1
1994 Kwok RP, Lundblad JR, Chrivia JC, Richards JP, Bächinger HP, Brennan RG, Roberts SG, Green MR, Goodman RH. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature. 370: 223-6. PMID 7913207 DOI: 10.1038/370223a0  1
1993 Schumacher MA, Macdonald JR, Björkman J, Mowbray SL, Brennan RG. Structural analysis of the purine repressor, an Escherichia coli DNA-binding protein. The Journal of Biological Chemistry. 268: 12282-8. PMID 8509365  1
1993 Spiro C, Richards JP, Chandrasekaran S, Brennan RG, Mcmurray CT. Secondary structure creates mismatched base pairs required for high-affinity binding of cAMP response element-binding protein to the human enkephalin enhancer Proceedings of the National Academy of Sciences of the United States of America. 90: 4606-4610. PMID 8506306  1
1993 Brennan RG. The winged-helix DNA-binding motif: Another helix-turn-helix takeoff Cell. 74: 773-776. PMID 8374950 DOI: 10.1016/0092-8674(93)90456-Z  1
1993 Loriaux MM, Rehfuss RP, Brennan RG, Goodman RH. Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active. Proceedings of the National Academy of Sciences of the United States of America. 90: 9046-50. PMID 8105470  1
1992 Schumacher MA, Choi KY, Zalkin H, Brennan RG. Crystallization and preliminary X-ray studies on the co-repressor binding domain of the Escherichia coli purine repressor Journal of Molecular Biology. 225: 1131-1133. PMID 1613795 DOI: 10.1016/0022-2836(92)90111-V  1
1992 Wilson KP, Shewchuk LM, Brennan RG, Otsuka AJ, Matthews BW. Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. Proceedings of the National Academy of Sciences of the United States of America. 89: 9257-61. PMID 1409631 DOI: 10.1073/pnas.89.19.9257  1
1992 Brennan RG. DNA recognition by the helix-turn-helix motif. Current Opinion in Structural Biology 1992, 2: 100...-108 Current Opinion in Structural Biology. 2: 100-108. DOI: 10.1016/0959-440X(92)90184-9  1
1991 Dixon MM, Brennan RG, Matthews BW. Structure of γ-chymotrypsin in the range pH 2.0 to pH 10.5 suggests that γ-chymotrypsin is a covalent acyl-enzyme adduct at low pH International Journal of Biological Macromolecules. 13: 89-96. PMID 1888717 DOI: 10.1016/0141-8130(91)90054-X  1
1991 Carr DW, Stofko-Hahn RE, Fraser IDC, Bishop SM, Acott TS, Brennan RG, Scott JD. Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif Journal of Biological Chemistry. 266: 14188-14192. PMID 1860836  1
1991 Brennan RG. Interactions of the helix-turn-helix binding domain. Current opinion in structural biology 1991, 1:80-88 Current Opinion in Structural Biology. 1: 80-88. DOI: 10.1016/0959-440X(91)90015-L  1
1990 Brennan RG, Roderick SL, Takeda Y, Matthews BW. Protein-DNA conformational changes in the crystal structure of a λ Cro-operator complex Proceedings of the National Academy of Sciences of the United States of America. 87: 8165-8169. PMID 2146682  1
1989 Brennan RG, Matthews BW. Structural basis of DNA-protein recognition Trends in Biochemical Sciences. 14: 286-290. PMID 2672451 DOI: 10.1016/0968-0004(89)90066-2  1
1989 Brennan RG, Matthews BW. The helix-turn-helix DNA binding motif Journal of Biological Chemistry. 264: 1903-1906. PMID 2644244  1
1989 Brennan RG, Vasu S, Matthews BW, Otsuka AJ. Crystallization of the bifunctional biotin operon repressor. The Journal of Biological Chemistry. 264: 5. PMID 2642476  1
1988 Brennan RG, Wozniak J, Faber R, Matthews BW. Crystallization of mutant lysozymes from bacteriophage T4 Journal of Crystal Growth. 90: 160-167. DOI: 10.1016/0022-0248(88)90311-9  1
1986 Brennan RG, Pyzalska D, Blonski WJ, Hruska FE, Sundaralingam M. Crystal structure of the promutagen O4-methylthymidine: importance of the anti conformation of the O(4) methoxy group and possible mispairing of O4-methylthymidine with guanine. Biochemistry. 25: 1181-5. PMID 3964665  1
1986 Brennan RG, Takeda Y, Kim J, Anderson WF, Matthews BW. Crystallization of a complex of cro repressor with a 17 base-pair operator Journal of Molecular Biology. 188: 115-118. PMID 2940371 DOI: 10.1016/0022-2836(86)90488-2  1
1986 Brennan RG, Kim J, Takeda Y, Anderson WF, Matthews BW. Studies on the crystallization of the cro protein-pseudo OR3 complex Journal of Crystal Growth. 76: 715-718. DOI: 10.1016/0022-0248(86)90189-2  1
1985 Brennan RG, Sundaralingam M. Crystallization and preliminary crystallographic studies of the decadeoxyoligonucleotide d(CpGpTpApCpGpTpApCpG) Journal of Molecular Biology. 181: 561-563. PMID 3999140 DOI: 10.1016/0022-2836(85)90429-2  1
1984 Brennan RG, Kondo NS, Sundaralingam M. X-ray structure of cytidine-5′-O-dimethylphosphate. Novel stacking between the ribosyl O(2′) hydroxyl oxygen atom and the base Nucleic Acids Research. 12: 6813-6825. PMID 6548306 DOI: 10.1093/nar/12.17.6813  1
1984 Brennan RG, Kondo NS, Sundaralingam M. Crystal structure and conformation of the phosphotriester adenosine 5′-O-(diethyl phosphate). Possible steric and conformational mechanisms for the biochemical and biological effects arising from phosphate alkylation Journal of the American Chemical Society. 106: 5671-5676.  1
1983 Brennan RG, Privé GG, Blonski WJP, Hruska FE, Sundaralingam M. Crystal structure of o4-methyl uridine: Stacking induced changes in the geometry of the pyrimidine ring and its mutagenic role Journal of Biomolecular Structure and Dynamics. 1: 939-945. PMID 6400906 DOI: 10.1080/07391102.1983.10507495  1
1983 Brennan RG, Privé GG, Blonski WJP, Hruska FE, Sundaralingam M. Molecular and crystal structure of O4-methyluridine. Reaction coordinates for an incipient nucleophilic attack seen by short intermolecular sugar-base interactions Journal of the American Chemical Society. 105: 7737-7742.  1
1981 Holtz A, Brennan RG, Battista D, Terner C. Androgen control of an inhibitory modulator of phosphodiesterase in rat epididymis and prostate. Endocrinology. 108: 1538-44. PMID 6258908 DOI: 10.1210/endo-108-4-1538  1
1980 Terner C, Holtz A, Brennan RG, Battista D. Androgen control of phosphodiesterase modulator in epididymis and prostate of rat Federation Proceedings. 39: 3765.  1
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