Gary A. Piazza - Publications

Affiliations: 
Biochemistry and Molecular Genetics University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Biochemistry, Cell Biology, Medicine and Surgery

94 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Almutairi MS, Hassan ES, Keeton AB, Piazza GA, Abdelhameed AS, Attia MI. Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins. Drug Design, Development and Therapy. 13: 3069-3078. PMID 31695325 DOI: 10.2147/DDDT.S208241  0.68
2019 Adamska A, Domenichini A, Capone E, Damiani V, Akkaya BG, Linton KJ, Di Sebastiano P, Chen X, Keeton AB, Ramirez-Alcantara V, Maxuitenko Y, Piazza GA, De Laurenzi V, Sala G, Falasca M. Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer. Journal of Experimental & Clinical Cancer Research : Cr. 38: 312. PMID 31378204 DOI: 10.1186/s13046-019-1308-7  0.68
2019 Abd El-Aleam RH, George RF, Lee KJ, Keeton AB, Piazza GA, Kamel AA, El-Daly ME, Hassan GS, Abdel-Rahman HM. Design and synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity. Archiv Der Pharmazie. e1900002. PMID 31353608 DOI: 10.1002/ardp.201900002  0.68
2018 Eldehna WM, Al-Wabli RI, Almutairi MS, Keeton AB, Piazza GA, Abdel-Aziz HA, Attia MI. Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents. Journal of Enzyme Inhibition and Medicinal Chemistry. 33: 867-878. PMID 29707975 DOI: 10.1080/14756366.2018.1462802  0.68
2018 El-Sharkawy LY, El-Sakhawy RA, Abdel-Halim M, Lee K, Piazza GA, Ducho C, Hartmann RW, Abadi AH. Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors. Archiv Der Pharmazie. PMID 29656464 DOI: 10.1002/ardp.201800018  0.68
2017 Zhu B, Lindsey A, Li N, Lee K, Ramirez-Alcantara V, Canzoneri JC, Fajardo A, Madeira da Silva L, Thomas M, Piazza JT, Yet L, Eberhardt BT, Gurpinar E, Otali D, Grizzle W, ... ... Piazza GA, et al. Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling. Oncotarget. 8: 69264-69280. PMID 29050202 DOI: 10.18632/oncotarget.20566  0.68
2017 Abdel-Aziz HA, Eldehna WM, Keeton AB, Piazza GA, Kadi AA, Attwa MW, Abdelhameed AS, Attia MI. Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling. Drug Design, Development and Therapy. 11: 2333-2346. PMID 28848327 DOI: 10.2147/DDDT.S140164  0.68
2017 Attia MI, Eldehna WM, Afifi SA, Keeton AB, Piazza GA, Abdel-Aziz HA. New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres. Plos One. 12: e0181241. PMID 28742842 DOI: 10.1371/journal.pone.0181241  0.68
2017 Keeton AB, Salter EA, Piazza GA. The RAS-Effector Interaction as a Drug Target. Cancer Research. PMID 28062402 DOI: 10.1158/0008-5472.CAN-16-0938  0.68
2016 Whitt JD, Keeton AB, Gary BD, Sklar LA, Sodani K, Chen ZS, Piazza GA. Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion. Journal of Biomedical Research. 30: 120-133. PMID 28276667 DOI: 10.7555/JBR.30.20150108  0.68
2016 Chung WJ, Goeckeler-Fried JL, Havasi V, Chiang A, Rowe SM, Plyler ZE, Hong JS, Mazur M, Piazza GA, Keeton AB, White EL, Rasmussen L, Weissman AM, Denny RA, Brodsky JL, et al. Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. Plos One. 11: e0163615. PMID 27732613 DOI: 10.1371/journal.pone.0163615  0.68
2016 Prasain JK, Rajbhandari R, Keeton AB, Piazza GA, Barnes S. Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells. Food & Function. 7: 4012-4019. PMID 27711848 DOI: 10.1039/c6fo00499g  0.68
2016 Rezk MS, Abdel-Halim M, Keeton A, Franklin D, Bauer M, Boeckler FM, Engel M, Hartmann RW, Zhang Y, Piazza GA, Abadi AH. Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex. Chemical & Pharmaceutical Bulletin. 64: 34-41. PMID 26726742 DOI: 10.1248/cpb.c15-00608  0.68
2016 Abdel-Rahman HM, Abdel-Aziz M, Tinsley HN, Gary BD, Canzoneri JC, Piazza GA. Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors. Archiv Der Pharmazie. 349: 104-11. PMID 26686665 DOI: 10.1002/ardp.201500363  0.68
2016 Whitt JD, Keeton AB, Gary BD, Sklar LA, Sodani K, Chen ZS, Piazza GA. Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion Journal of Biomedical Research. 30: 120-133. DOI: 10.7555/JBR.30.20150108  0.68
2016 Prasain JK, Rajbhandari R, Keeton AB, Piazza GA, Barnes S. Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells Food and Function. 7: 4012-4019. DOI: 10.1039/c6fo00499g  0.68
2015 Elhady AK, Sigler SC, Noureldin N, Canzoneri JC, Ahmed NS, Piazza GA, Abadi AH. Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors. Scientia Pharmaceutica. 84: 428-446. PMID 28117310 DOI: 10.3390/scipharm84030428  0.68
2015 Lee K, Lindsey AS, Li N, Gary B, Andrews J, Keeton AB, Piazza GA. β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG. Oncotarget. PMID 26713600 DOI: 10.18632/oncotarget.6705  0.68
2015 Hassaan EA, Sigler SC, Ibrahim TM, Lee KJ, Cichon LK, Gary BD, Canzoneri JC, Piazza GA, Abadi AH. Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach. Medicinal Chemistry (Shariqah (United Arab Emirates)). PMID 26648332  0.68
2015 Li N, Chen X, Zhu B, Ramírez-Alcántara V, Canzoneri JC, Lee K, Sigler S, Gary B, Li Y, Zhang W, Moyer MP, Salter EA, Wierzbicki A, Keeton AB, Piazza GA. Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10. Oncotarget. PMID 26299804  0.68
2015 Fajardo AM, Piazza GA. Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention. American Journal of Physiology. Gastrointestinal and Liver Physiology. 309: G59-70. PMID 26021807 DOI: 10.1152/ajpgi.00101.2014  0.68
2015 Li N, Lee K, Xi Y, Zhu B, Gary BD, Ramírez-Alcántara V, Gurpinar E, Canzoneri JC, Fajardo A, Sigler S, Piazza JT, Chen X, Andrews J, Thomas M, Lu W, ... ... Piazza GA, et al. Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity. Oncogene. 34: 1499-509. PMID 24704829 DOI: 10.1038/onc.2014.94  0.68
2015 Li N, Chen X, Zhu B, Ramírez-Alcántara V, Canzoneri JC, Lee K, Sigler S, Gary B, Li Y, Zhang W, Moyer MP, Salter EA, Wierzbicki A, Keeton AB, Piazza GA. Suppression of ß-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10 Oncotarget. 6: 27403-27415. DOI: 10.18632/oncotarget.4741  0.68
2015 Tripathi K, Hussein UK, Anupalli R, Barnett R, Bachaboina L, Scalici J, Rocconi RP, Owen LB, Piazza GA, Palle K. Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation Oncotarget. 6: 5237-5252.  0.68
2014 Aboul-Fadl T, Al-Hamad SS, Lee K, Li N, Gary BD, Keeton AB, Piazza GA, Abdel-Hamid MK. Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 23: 4177-4188. PMID 27559271 DOI: 10.1007/s00044-014-0979-z  0.68
2014 Abdel-Rahman HM, Abdel-Aziz M, Canzoneri JC, Gary BD, Piazza GA. Novel quinazolin-4(3H)-one/Schiff base hybrids as antiproliferative and phosphodiesterase 4 inhibitors: design, synthesis, and docking studies. Archiv Der Pharmazie. 347: 650-7. PMID 24985336 DOI: 10.1002/ardp.201400083  0.68
2014 Arora R, Yates C, Gary BD, McClellan S, Tan M, Xi Y, Reed E, Piazza GA, Owen LB, Dean-Colomb W. Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer. Plos One. 9: e98370. PMID 24896091 DOI: 10.1371/journal.pone.0098370  0.68
2014 Fajardo AM, Piazza GA, Tinsley HN. The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment. Cancers. 6: 436-58. PMID 24577242 DOI: 10.3390/cancers6010436  0.68
2014 Gurpinar E, Grizzle WE, Piazza GA. NSAIDs inhibit tumorigenesis, but how? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1104-13. PMID 24311630 DOI: 10.1158/1078-0432.CCR-13-1573  0.68
2014 Aboul-Fadl T, Al-Hamad SS, Lee K, Li N, Gary BD, Keeton AB, Piazza GA, Abdel-Hamid MK. Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention Medicinal Chemistry Research. DOI: 10.1007/s00044-014-0979-z  0.68
2013 Awadallah FM, Piazza GA, Gary BD, Keeton AB, Canzoneri JC. Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity. European Journal of Medicinal Chemistry. 70: 273-9. PMID 24161704 DOI: 10.1016/j.ejmech.2013.10.003  0.68
2013 Abdel-Halim M, Keeton AB, Gurpinar E, Gary BD, Vogel SM, Engel M, Piazza GA, Boeckler FM, Hartmann RW, Abadi AH. Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53. Bioorganic & Medicinal Chemistry. 21: 7343-56. PMID 24139845 DOI: 10.1016/j.bmc.2013.09.055  0.68
2013 Wang ZM, Du WJ, Piazza GA, Xi Y. MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells. Acta Pharmacologica Sinica. 34: 1374-80. PMID 24122008 DOI: 10.1038/aps.2013.134  0.68
2013 Gurpinar E, Grizzle WE, Piazza GA. COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs. Frontiers in Oncology. 3: 181. PMID 23875171 DOI: 10.3389/fonc.2013.00181  0.68
2013 Hamed MM, Abou El Ella DA, Keeton AB, Piazza GA, Abadi AH, Hartmann RW, Engel M. 6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines. Chemmedchem. 8: 1495-504. PMID 23847159 DOI: 10.1002/cmdc.201300147  0.68
2013 Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi AH, Moyer MP, Grizzle WE, Chang WC, Clapper ML, Piazza GA. Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling. Molecular Cancer Therapeutics. 12: 1848-59. PMID 23804703 DOI: 10.1158/1535-7163.MCT-13-0048  0.68
2013 Arora S, Bhardwaj A, Singh S, Srivastava SK, McClellan S, Nirodi CS, Piazza GA, Grizzle WE, Owen LB, Singh AP. An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor κB- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4. The Journal of Biological Chemistry. 288: 21197-207. PMID 23740244 DOI: 10.1074/jbc.M113.484576  0.68
2013 Arafa RK, Hegazy GH, Piazza GA, Abadi AH. Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents. European Journal of Medicinal Chemistry. 63: 826-32. PMID 23584545 DOI: 10.1016/j.ejmech.2013.03.008  0.68
2013 Abadi AH, Hany MS, Elsharif SA, Eissa AA, Gary BD, Tinsley HN, Piazza GA. Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line. Chemical & Pharmaceutical Bulletin. 61: 405-10. PMID 23546000 DOI: DN/JST.JSTAGE/cpb/c12-00993  0.68
2013 Yi B, Piazza GA, Su X, Xi Y. MicroRNA and cancer chemoprevention. Cancer Prevention Research (Philadelphia, Pa.). 6: 401-9. PMID 23531448 DOI: 10.1158/1940-6207.CAPR-13-0032  0.68
2013 Gurpinar E, Grizzle WE, Shacka JJ, Mader BJ, Li N, Piazza NA, Russo S, Keeton AB, Piazza GA. A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy. Molecular Cancer Therapeutics. 12: 663-74. PMID 23443799 DOI: 10.1158/1535-7163.MCT-12-0785  0.68
2013 Shen G, Li X, Jia YF, Piazza GA, Xi Y. Hypoxia-regulated microRNAs in human cancer. Acta Pharmacologica Sinica. 34: 336-41. PMID 23377548 DOI: 10.1038/aps.2012.195  0.68
2013 El-Gamil DS, Ahmed NS, Gary BD, Piazza GA, Engel M, Hartmann RW, Abadi AH. Design of novel β-carboline derivatives with pendant 5-bromothienyl and their evaluation as phosphodiesterase-5 inhibitors. Archiv Der Pharmazie. 346: 23-33. PMID 23307609 DOI: 10.1002/ardp.201200334  0.68
2013 White MC, Johnson GG, Zhang W, Hobrath JV, Piazza GA, Grimaldi M. Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib. Journal of Neuroscience Research. 91: 393-406. PMID 23280445 DOI: 10.1002/jnr.23169  0.68
2013 Tinsley HN, Grizzle WE, Abadi A, Keeton A, Zhu B, Xi Y, Piazza GA. New NSAID targets and derivatives for colorectal cancer chemoprevention. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 191: 105-20. PMID 22893202 DOI: 10.1007/978-3-642-30331-9_6  0.68
2013 Hamed MM, Abou El Ella DA, Keeton AB, Piazza GA, Engel M, Hartmann RW, Abadi AH. Quinazoline and tetrahydropyridothieno[2,3-d]pyrimidine derivatives as irreversible EGFR tyrosine kinase inhibitors: Influence of the position 4 substituent Medchemcomm. 4: 1202-1207. DOI: 10.1039/c3md00118k  0.68
2012 Tinsley HN, Piazza GA. Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases. Current Colorectal Cancer Reports. 8: 325-330. PMID 23459242 DOI: 10.1007/s11888-012-0142-5  0.68
2012 Ahmed NS, Ali AH, El-Nashar SM, Gary BD, Fajardo AM, Tinsley HN, Piazza GA, Negri M, Abadi AH. Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives. European Journal of Medicinal Chemistry. 57: 329-43. PMID 23117589 DOI: 10.1016/j.ejmech.2012.09.029  0.68
2012 Arora S, Singh S, Piazza GA, Contreras CM, Panyam J, Singh AP. Honokiol: A novel natural agent for cancer prevention and therapy Current Molecular Medicine. 12: 1244-1252. PMID 22834827 DOI: 10.2174/156652412803833508  0.68
2012 Whitt JD, Li N, Tinsley HN, Chen X, Zhang W, Li Y, Gary BD, Keeton AB, Xi Y, Abadi AH, Grizzle WE, Piazza GA. A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity. Cancer Prevention Research (Philadelphia, Pa.). 5: 822-33. PMID 22556201 DOI: 10.1158/1940-6207.CAPR-11-0559  0.68
2012 Salama I, Abdel-Fattah MA, Hany MS, El-Sharif SA, El-Naggar MA, Rashied RM, Piazza GA, Abadi AH. CoMFA and CoMSIA studies of 1,2-dihydropyridine derivatives as anticancer agents. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 8: 372-83. PMID 22530888 DOI: 10.2174/157340612800786598  0.68
2012 Abdel-Fattah MA, El-Naggar MA, Rashied RM, Gary BD, Piazza GA, Abadi AH. Four-component synthesis of 1,2-dihydropyridine derivatives and their evaluation as anticancer agents. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 8: 392-400. PMID 22530887  0.68
2012 Li X, Gao L, Cui Q, Gary BD, Dyess DL, Taylor W, Shevde LA, Samant RS, Dean-Colomb W, Piazza GA, Xi Y. Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs. Oncogene. 31: 4979-86. PMID 22286762 DOI: 10.1038/onc.2011.655  0.68
2012 Gao L, Gao Y, Li X, Howell P, Kumar R, Su X, Vlassov AV, Piazza GA, Riker AI, Sun D, Xi Y. Aquaporins mediate the chemoresistance of human melanoma cells to arsenite. Molecular Oncology. 6: 81-7. PMID 22130551 DOI: 10.1016/j.molonc.2011.11.001  0.68
2012 Li X, Zhang J, Gao L, McClellan S, Finan MA, Butler TW, Owen LB, Piazza GA, Xi Y. MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit. Cell Death and Differentiation. 19: 378-86. PMID 21979467 DOI: 10.1038/cdd.2011.127  0.68
2011 Abadi AH, Lehmann J, Piazza GA, Abdel-Halim M, Ali MS. Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors. International Journal of Medicinal Chemistry. 2011: 562421. PMID 27471602 DOI: 10.1155/2011/562421  0.68
2011 Lu W, Lin C, Roberts MJ, Waud WR, Piazza GA, Li Y. Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway. Plos One. 6: e29290. PMID 22195040 DOI: 10.1371/journal.pone.0029290  0.68
2011 Tinsley HN, Gary BD, Keeton AB, Lu W, Li Y, Piazza GA. Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells. Cancer Prevention Research (Philadelphia, Pa.). 4: 1275-84. PMID 21505183 DOI: 10.1158/1940-6207.CAPR-11-0095  0.68
2011 Ahmed NS, Gary BD, Tinsley HN, Piazza GA, Laufer S, Abadi AH. Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors. Archiv Der Pharmazie. 344: 149-57. PMID 21384413 DOI: 10.1002/ardp.201000236  0.68
2011 Li HF, Keeton A, Vitolo M, Maddox C, Rasmussen L, Hobrath J, White EL, Park BH, Piazza GA, Kim JS, Waldman T. A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells. Journal of Biomolecular Screening. 16: 383-93. PMID 21335596 DOI: 10.1177/1087057110397357  0.68
2011 Mohamed HA, Girgis NM, Wilcken R, Bauer MR, Tinsley HN, Gary BD, Piazza GA, Boeckler FM, Abadi AH. Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties. Journal of Medicinal Chemistry. 54: 495-509. PMID 21189023 DOI: 10.1021/jm100842v  0.68
2010 Piazza GA, Keeton AB, Tinsley HN, Whitt JD, Gary BD, Mathew B, Singh R, Grizzle WE, Reynolds RC. NSAIDs: Old Drugs Reveal New Anticancer Targets. Pharmaceuticals (Basel, Switzerland). 3: 1652-1667. PMID 27713322 DOI: 10.3390/ph3051652  0.68
2010 Ahmed NS, Gary BD, Piazza GA, Tinsley HN, Laufer S, Abadi AH. A novel access to arylated and heteroarylated beta-carboline based PDE5 inhibitors. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 6: 374-87. PMID 21054274 DOI: 10.2174/157340610793563992  0.68
2010 Tinsley HN, Gary BD, Thaiparambil J, Li N, Lu W, Li Y, Maxuitenko YY, Keeton AB, Piazza GA. Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition. Cancer Prevention Research (Philadelphia, Pa.). 3: 1303-13. PMID 20876730 DOI: 10.1158/1940-6207.CAPR-10-0030  0.68
2010 Zhang Y, Zhang J, Wang L, Quealy E, Gary BD, Reynolds RC, Piazza GA, Lü J. A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model. Cancer Prevention Research (Philadelphia, Pa.). 3: 885-95. PMID 20587701 DOI: 10.1158/1940-6207.CAPR-09-0273  0.68
2010 Zhang L, Nebane NM, Wennerberg K, Li Y, Neubauer V, Hobrath JV, McKellip S, Rasmussen L, Shindo N, Sosa M, Maddry JA, Ananthan S, Piazza GA, White EL, Harsay E. A high-throughput screen for chemical inhibitors of exocytic transport in yeast. Chembiochem : a European Journal of Chemical Biology. 11: 1291-301. PMID 20461743 DOI: 10.1002/cbic.200900681  0.68
2010 Abadi AH, Gary BD, Tinsley HN, Piazza GA, Abdel-Halim M. Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective. European Journal of Medicinal Chemistry. 45: 1278-86. PMID 20206015 DOI: 10.1016/j.ejmech.2009.10.046  0.68
2010 Abadi AH, Abouel-Ella DA, Lehmann J, Tinsley HN, Gary BD, Piazza GA, Abdel-Fattah MA. Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach. European Journal of Medicinal Chemistry. 45: 90-7. PMID 19836860 DOI: 10.1016/j.ejmech.2009.09.029  0.68
2010 Piazza GA, Keeton AB, Tinsley HN, Whitt JD, Gary B, Mathew B, Singh R, Grizzle WE, Reynolds RC. NSAIDs: Old drugs reveal new anticancer targets Pharmaceuticals. 3: 1652-1667. DOI: 10.3390/ph3051652  0.68
2009 Tinsley HN, Gary BD, Keeton AB, Zhang W, Abadi AH, Reynolds RC, Piazza GA. Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Molecular Cancer Therapeutics. 8: 3331-40. PMID 19996273 DOI: 10.1158/1535-7163.MCT-09-0758  0.68
2009 Abadi AH, Abouel-Ella DA, Ahmed NS, Gary BD, Thaiparambil JT, Tinsley HN, Keeton AB, Piazza GA. Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents. Arzneimittel-Forschung. 59: 415-21. PMID 19813465  0.68
2009 Abadi AH, Ibrahim TM, Abouzid KM, Lehmann J, Tinsley HN, Gary BD, Piazza GA. Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors. Bioorganic & Medicinal Chemistry. 17: 5974-82. PMID 19628397 DOI: 10.1016/j.bmc.2009.06.063  0.68
2009 Piazza GA, Keeton AB, Tinsley HN, Gary BD, Whitt JD, Mathew B, Thaiparambil J, Coward L, Gorman G, Li Y, Sani B, Hobrath JV, Maxuitenko YY, Reynolds RC. A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity. Cancer Prevention Research (Philadelphia, Pa.). 2: 572-80. PMID 19470791 DOI: 10.1158/1940-6207.CAPR-09-0001  0.68
2009 Lu W, Tinsley HN, Keeton A, Qu Z, Piazza GA, Li Y. Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation. European Journal of Pharmacology. 602: 8-14. PMID 19026633 DOI: 10.1016/j.ejphar.2008.10.053  0.68
2008 Jia L, Noker PE, Piazza GA, Leuschner C, Hansel W, Gorman GS, Coward LU, Tomaszewski J. Pharmacokinetics and pharmacodynamics of Phor21-betaCG(ala), a lytic peptide conjugate. The Journal of Pharmacy and Pharmacology. 60: 1441-8. PMID 18957164 DOI: 10.1211/jpp.60.11.0004  0.68
2004 Basler JW, Piazza GA. Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention. The Journal of Urology. 171: S59-62; discussion S. PMID 14713756 DOI: 10.1097/01.ju.0000107839.06670.27  0.68
2004 Thompson IM, Albanes D, Basler JW, Crawford ED, Denis LJ, Djavan B, Fleshner N, Johnson-Pais TL, Klein EA, Kristal AR, Lucia MS, Parnes HL, Piazza GA, Platz EA, Pollock BH, et al. First International Conference on Chemoprevention of Prostate Cancer. Overview consensus statement. The Journal of Urology. 171: S3-4. PMID 14713744 DOI: 10.1097/01.ju.0000107100.06725.51  0.68
2003 Lim JT, Piazza GA, Pamukcu R, Thompson WJ, Weinstein IB. Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 4972-82. PMID 14581372  0.68
2003 Joe AK, Liu H, Xiao D, Soh JW, Pinto JT, Beer DG, Piazza GA, Thompson WJ, Weinstein IB. Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cells. Journal of Experimental Therapeutics & Oncology. 3: 83-94. PMID 12822514 DOI: 10.1046/j.1359-4117.2003.01076.x  0.68
2001 Piazza GA, Thompson WJ, Pamukcu R, Alila HW, Whitehead CM, Liu L, Fetter JR, Gresh WE, Klein-Szanto AJ, Farnell DR, Eto I, Grubbs CJ. Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. Cancer Research. 61: 3961-8. PMID 11358813  0.68
2000 Lawson KR, Ignatenko NA, Piazza GA, Cui H, Gerner EW. Influence of K-ras activation on the survival responses of Caco-2 cells to the chemopreventive agents sulindac and difluoromethylornithine Cancer Epidemiology Biomarkers and Prevention. 9: 1155-1162. PMID 11097222  0.68
2000 Soh JW, Mao Y, Kim MG, Pamukcu R, Li H, Piazza GA, Thompson WJ, Weinstein IB. Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 4136-41. PMID 11051267  0.68
2000 Thompson WJ, Piazza GA, Li H, Liu L, Fetter J, Zhu B, Sperl G, Ahnen D, Pamukcu R. Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Research. 60: 3338-42. PMID 10910034  0.68
1999 Lim JT, Piazza GA, Han EK, Delohery TM, Li H, Finn TS, Buttyan R, Yamamoto H, Sperl GJ, Brendel K, Gross PH, Pamukcu R, Weinstein IB. Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines. Biochemical Pharmacology. 58: 1097-107. PMID 10484067 DOI: 10.1016/S0006-2952(99)00200-2  0.68
1999 Goluboff ET, Shabsigh A, Saidi JA, Weinstein IB, Mitra N, Heitjan D, Piazza GA, Pamukcu R, Buttyan R, Olsson CA. Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis. Urology. 53: 440-5. PMID 9933075 DOI: 10.1016/S0090-4295(98)00513-5  0.68
1998 Skopińska-Rózewska E, Piazza GA, Sommer E, Pamukcu R, Barcz E, Filewska M, Kupis W, Caban R, Rudziński P, Bogdan J, Mlekodaj S, Sikorska E. Inhibition of angiogenesis by sulindac and its sulfone metabolite (FGN- 1): A potential mechanism for their antineoplastic properties International Journal of Tissue Reactions. 20: 85-89. PMID 9894180  0.68
1998 Malkinson AM, Koski KM, Dwyer-Nield LD, Rice PL, Rioux N, Castonguay A, Ahnen DJ, Thompson H, Pamukcu R, Piazza GA. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumor formation by FGN-1 (sulindac sulfone). Carcinogenesis. 19: 1353-6. PMID 9744528 DOI: 10.1093/carcin/19.8.1353  0.68
1998 Han EK, Arber N, Yamamoto H, Lim JT, Delohery T, Pamukcu R, Piazza GA, Xing WQ, Weinstein IB. Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines. Breast Cancer Research and Treatment. 48: 195-203. PMID 9598866 DOI: 10.1023/A:1005924730450  0.68
1997 Arber N, Han EK, Sgambato A, Piazza GA, Delohery TM, Begemann M, Weghorst CM, Kim NH, Pamukcu R, Ahnen DJ, Reed JC, Weinstein IB, Holt PR. A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes. Gastroenterology. 113: 1892-900. PMID 9394728  0.68
1997 Piazza GA, Alberts DS, Hixson LJ, Paranka NS, Li H, Finn T, Bogert C, Guillen JM, Brendel K, Gross PH, Sperl G, Ritchie J, Burt RW, Ellsworth L, Ahnen DJ, et al. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels Cancer Research. 57: 2909-2915. PMID 9230200  0.68
1997 Piazza GA, Rahm AK, Finn TS, Fryer BH, Li H, Stoumen AL, Pamukcu R, Ahnen DJ. Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction Cancer Research. 57: 2452-2459. PMID 9192825  0.68
1997 Thompson HJ, Jiang C, Lu J, Mehta RG, Piazza GA, Paranka NS, Pamukcu R, Ahnen DJ. Sulfone metabolite of sulindac inhibits mammary carcinogenesis. Cancer Research. 57: 267-71. PMID 9000566  0.68
1995 Piazza GA, Rahm AL, Krutzsch M, Sperl G, Paranka NS, Gross PH, Brendel K, Burt RW, Alberts DS, Pamukcu R. Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. Cancer Research. 55: 3110-6. PMID 7606732  0.68
1995 Thompson HJ, Briggs S, Paranka NS, Piazza GA, Brendel K, Gross PH, Sperl GJ, Pamukcu R, Ahnen DJ. Inhibition of mammary carcinogenesis in rats by sulfone metabolite of sulindac. Journal of the National Cancer Institute. 87: 1259-60. PMID 7563174  0.68
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