Alexei Degterev - Publications

Affiliations: 
Biochemistry Sackler School of Graduate Biomedical Sciences (Tufts University) 
Area:
Biochemistry, Cell Biology, Molecular Biology

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Pattni BS, Nagelli SG, Aryasomayajula B, Deshpande PP, Kulkarni A, Hartner WC, Thakur G, Degterev A, Torchilin VP. Targeting of Micelles and Liposomes Loaded with the Pro-Apoptotic Drug, NCL-240, into NCI/ADR-RES Cells in a 3D Spheroid Model. Pharmaceutical Research. PMID 27351426 DOI: 10.1007/s11095-016-1978-1  0.48
2016 Degterev A, Linkermann A. Generation of small molecules to interfere with regulated necrosis. Cellular and Molecular Life Sciences : Cmls. PMID 27048812 DOI: 10.1007/s00018-016-2198-x  0.48
2016 Riehle R, Pattni B, Jhaveri A, Kulkarni A, Thakur G, Degterev A, Torchilin V. Combination Nanopreparations of a Novel Proapoptotic Drug – NCL-240, TRAIL and siRNA Pharmaceutical Research. 1-15. DOI: 10.1007/s11095-016-1899-z  0.48
2015 Sriraman SK, Geraldo V, Luther E, Degterev A, Torchilin V. Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro. Journal of Controlled Release : Official Journal of the Controlled Release Society. 220: 160-8. PMID 26497930 DOI: 10.1016/j.jconrel.2015.10.037  0.48
2015 Bullock AN, Degterev A. Targeting RIPK1,2,3 to combat inflammation. Oncotarget. 6: 34057-8. PMID 26472031 DOI: 10.18632/oncotarget.6106  0.48
2015 Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Reports. 10: 1850-60. PMID 25801024 DOI: 10.1016/j.celrep.2015.02.052  0.48
2015 Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors Chemistry and Biology. DOI: 10.1016/j.chembiol.2015.07.017  0.48
2014 Kommagalla Y, Cornea S, Riehle R, Torchilin V, Degterev A, Ramana CV. Optimization of the anti-cancer activity of phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching a thiourea with 1,2,3-triazole. Medchemcomm. 5: 1359-1363. PMID 25505943 DOI: 10.1039/C4MD00109E  0.48
2014 Degterev A, Zhou W, Maki JL, Yuan J. Assays for necroptosis and activity of RIP kinases. Methods in Enzymology. 545: 1-33. PMID 25065884 DOI: 10.1016/B978-0-12-801430-1.00001-9  0.48
2014 Zhu X, Park J, Golinski J, Qiu J, Khuman J, Lee CC, Lo EH, Degterev A, Whalen MJ. Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1531-9. PMID 24938400 DOI: 10.1038/jcbfm.2014.113  0.48
2014 Dvoriantchikova G, Degterev A, Ivanov D. Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia-reperfusion-induced retinal damage. Experimental Eye Research. 123: 1-7. PMID 24751757 DOI: 10.1016/j.exer.2014.04.009  0.48
2014 Schworer SA, Smirnova II, Kurbatova I, Bagina U, Churova M, Fowler T, Roy AL, Degterev A, Poltorak A. Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice. The Journal of Biological Chemistry. 289: 14422-33. PMID 24706750 DOI: 10.1074/jbc.M114.547547  0.48
2014 Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ. Akt and mTOR mediate programmed necrosis in neurons. Cell Death & Disease. 5: e1084. PMID 24577082 DOI: 10.1038/cddis.2014.69  0.48
2014 Newton K, Hildebrand JM, Shen Z, Rodriguez D, Alvarez-Diaz S, Petersen S, Shah S, Dugger DL, Huang C, Auwerx J, Vandenabeele P, Green DR, Ashkenazi A, Dixit VM, Kaiser WJ, ... ... Degterev A, et al. Is SIRT2 required for necroptosis? Nature. 506: E4-6. PMID 24572428 DOI: 10.1038/nature13024  0.48
2013 Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S. Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases. Proceedings of the National Academy of Sciences of the United States of America. 110: E3109-18. PMID 23898178 DOI: 10.1073/pnas.1301218110  0.48
2013 Riehle RD, Cornea S, Degterev A. Role of phosphatidylinositol 3,4,5-trisphosphate in cell signaling. Advances in Experimental Medicine and Biology. 991: 105-39. PMID 23775693 DOI: 10.1007/978-94-007-6331-9_7  0.48
2013 Maki JL, Degterev A. Activity assays for receptor-interacting protein kinase 1:a key regulator of necroptosis. Methods in Molecular Biology (Clifton, N.J.). 1004: 31-42. PMID 23733567 DOI: 10.1007/978-1-62703-383-1_3  0.48
2013 Maki JL, Tres Brazell J, Teng X, Cuny GD, Degterev A. Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system. Protein Expression and Purification. 89: 156-61. PMID 23523699 DOI: 10.1016/j.pep.2013.03.002  0.48
2013 Riehle RD, Cornea S, Degterev A, Torchilin V. Micellar formulations of pro-apoptotic DM-PIT-1 analogs and TRAIL in vitro and in vivo. Drug Delivery. 20: 78-85. PMID 23495715 DOI: 10.3109/10717544.2013.766780  0.48
2013 Xie T, Peng W, Liu Y, Yan C, Maki J, Degterev A, Yuan J, Shi Y. Structural basis of RIP1 inhibition by necrostatins. Structure (London, England : 1993). 21: 493-9. PMID 23473668 DOI: 10.1016/j.str.2013.01.016  0.48
2013 McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A. Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. Plos One. 8: e56576. PMID 23469174 DOI: 10.1371/journal.pone.0056576  0.48
2013 Degterev A, Maki JL, Yuan J. Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase. Cell Death and Differentiation. 20: 366. PMID 23197295 DOI: 10.1038/cdd.2012.133  0.48
2012 Takahashi N, Duprez L, Grootjans S, Cauwels A, Nerinckx W, Duhadaway JB, Goossens V, Roelandt R, Van Hauwermeiren F, Libert C, Declercq W, Callewaert N, Prendergast GC, Degterev A, Yuan J, et al. Necrostatin-1 analogues: Critical issues on the specificity, activity and in vivo use in experimental disease models Cell Death and Disease. 3. PMID 23190609 DOI: 10.1038/cddis.2012.176  0.48
2012 Choi S, Keys H, Staples RJ, Yuan J, Degterev A, Cuny GD. Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorganic & Medicinal Chemistry Letters. 22: 5685-8. PMID 22832318 DOI: 10.1016/j.bmcl.2012.06.098  0.48
2012 Maki JL, Smith EE, Teng X, Ray SS, Cuny GD, Degterev A. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Analytical Biochemistry. 427: 164-74. PMID 22658960 DOI: 10.1016/j.ab.2012.05.019  0.48
2012 Ofengeim D, Shi P, Miao B, Fan J, Xia X, Fan Y, Lipinski MM, Hashimoto T, Polydoro M, Yuan J, Wong ST, Degterev A. Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening. The Journal of Biological Chemistry. 287: 8714-23. PMID 22277654 DOI: 10.1074/jbc.M111.290957  0.48
2012 Miao B, Skidan I, Yang J, You Z, Fu X, Famulok M, Schaffhausen B, Torchilin V, Yuan J, Degterev A. Inhibition of cell migration by PITENINs: The role of ARF6 Oncogene. 31: 4317-4332. PMID 22179837 DOI: 10.1038/onc.2011.593  0.48
2012 Park J, Zhang J, Qiu J, Zhu X, Degterev A, Lo EH, Whalen MJ. Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 330-40. PMID 21934697 DOI: 10.1038/jcbfm.2011.131  0.48
2011 Badr CE, Wurdinger T, Nilsson J, Niers JM, Whalen M, Degterev A, Tannous BA. Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway. Neuro-Oncology. 13: 1213-24. PMID 21757445 DOI: 10.1093/neuonc/nor067  0.48
2011 McNamara CR, Degterev A. Small-molecule inhibitors of the PI3K signaling network. Future Medicinal Chemistry. 3: 549-65. PMID 21526896 DOI: 10.4155/fmc.11.12  0.48
2011 Skidan I, Grunwald J, Thekkedath R, Degterev A, Torchilin V. A HPLC method for the quantitative determination of N-(2-hydroxy-5-nitrophenylcarbamothioyl)-3,5-dimethylbenzamide in biological samples. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 879: 1610-6. PMID 21514904 DOI: 10.1016/j.jchromb.2011.03.055  0.48
2011 Miao B, Degterev A. Targeting phospshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonists. Autophagy. 7: 650-1. PMID 21460619 DOI: 10.4161/auto.7.6.15248  0.48
2010 Miao B, Skidan I, Yang J, Lugovskoy A, Reibarkh M, Long K, Brazell T, Durugkar KA, Maki J, Ramana CV, Schaffhausen B, Wagner G, Torchilin V, Yuan J, Degterev A. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proceedings of the National Academy of Sciences of the United States of America. 107: 20126-31. PMID 21041639 DOI: 10.1073/pnas.1004522107  0.48
2010 Huang Y, Zhou X, Miao B, Lipinski M, Zhang Y, Li F, Degterev A, Yuan J, Hu G, Wong ST. A computational framework for studying neuron morphology from in vitro high content neuron-based screening. Journal of Neuroscience Methods. 190: 299-309. PMID 20580743 DOI: 10.1016/j.jneumeth.2010.05.012  0.48
2010 Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. Journal of Neuroscience Research. 88: 1569-76. PMID 20025059 DOI: 10.1002/jnr.22314  0.48
2010 Ramana CV, Patel P, Vanka K, Miao B, Degterev A. A combined experimental and density functional theory study on the Pd-mediated cycloisomerization of o-alkynylnitrobenzenes - Synthesis of isatogens and their evaluation as modulators of ROS-mediated cell death European Journal of Organic Chemistry. 5955-5966. DOI: 10.1002/ejoc.201000769  0.48
2009 Huang Y, Zhou X, Miao B, Lipinski M, Xia Z, Hu G, Degterev A, Yuan J, Wong ST. An Image Based System Biology Approach for Alzheimer's Disease Pathway Analysis. Ieee/Nih Life Science Systems and Applications Workshop. Ieee/Nih Life Science Systems and Applications Workshop. 2009: 128-132. PMID 20585413 DOI: 10.1109/LISSA.2009.4906726  0.48
2009 Miao B, Degterev A. Methods to analyze cellular necroptosis. Methods in Molecular Biology (Clifton, N.J.). 559: 79-93. PMID 19609750 DOI: 10.1007/978-1-60327-017-5_6  0.48
2009 Skidan I, Miao B, Thekkedath RV, Dholakia P, Degterev A, Torchilin V. In vitro cytotoxicity of novel pro-apoptotic agent DM-PIT-1 in PEG-PE-based micelles alone and in combination with TRAIL. Drug Delivery. 16: 45-51. PMID 19555308 DOI: 10.1080/10717540802517951  0.48
2009 Sánchez-Olea R, Calera MR, Degterev A. Molecular pathways involved in cell death after chemically induced DNA damage. Exs. 99: 209-30. PMID 19157063 DOI: 10.1007/978-3-7643-8336-7_8  0.48
2008 Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell. 135: 1311-23. PMID 19109899 DOI: 10.1016/j.cell.2008.10.044  0.48
2008 Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proceedings of the National Academy of Sciences of the United States of America. 105: 17463-8. PMID 18981423 DOI: 10.1073/pnas.0808043105  0.48
2008 Zheng W, Degterev A, Hsu E, Yuan J, Yuan C. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorganic & Medicinal Chemistry Letters. 18: 4932-5. PMID 18768316 DOI: 10.1016/j.bmcl.2008.08.058  0.48
2008 You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA, Whalen MJ. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1564-73. PMID 18493258 DOI: 10.1038/jcbfm.2008.44  0.48
2008 Teng X, Keys H, Yuan J, Degterev A, Cuny GD. Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 3219-23. PMID 18467094 DOI: 10.1016/j.bmcl.2008.04.048  0.48
2008 Degterev A, Yuan J. Expansion and evolution of cell death programmes. Nature Reviews. Molecular Cell Biology. 9: 378-90. PMID 18414491 DOI: 10.1038/nrm2393  0.48
2008 Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology. 4: 313-21. PMID 18408713 DOI: 10.1038/nchembio.83  0.48
2008 Cuny GD, Degterev A, Yuan J. Necroptosis - A novel cell death mechanism Drugs of the Future. 33: 225-233. DOI: 10.1358/dof.2008.033.03.1173882  0.48
2007 Yi CH, Sogah DK, Boyce M, Degterev A, Christofferson DE, Yuan J. A genome-wide RNAi screen reveals multiple regulators of caspase activation. The Journal of Cell Biology. 179: 619-26. PMID 17998402 DOI: 10.1083/jcb.200708090  0.48
2007 Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 6836-40. PMID 17964153 DOI: 10.1016/j.bmcl.2007.10.024  0.48
2007 Zhang Y, Zhou X, Degterev A, Lipinski M, Adjeroh D, Yuan J, Wong ST. Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays. Neuroimage. 35: 1502-15. PMID 17363284 DOI: 10.1016/j.neuroimage.2007.01.014  0.48
2007 Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Structure-activity relationship study of tricyclic necroptosis inhibitors. Journal of Medicinal Chemistry. 50: 1886-95. PMID 17361994 DOI: 10.1021/jm061016o  0.48
2007 Wang K, Li J, Degterev A, Hsu E, Yuan J, Yuan C. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorganic & Medicinal Chemistry Letters. 17: 1455-65. PMID 17270434 DOI: 10.1016/j.bmcl.2006.11.056  0.48
2007 Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 128: 257-67. PMID 17254965 DOI: 10.1016/j.cell.2006.11.046  0.48
2007 Zhang Y, Zhou X, Degterev A, Lipinski M, Adjeroh D, Yuan J, Wong ST. A novel tracing algorithm for high throughput imaging Screening of neuron-based assays. Journal of Neuroscience Methods. 160: 149-62. PMID 16987551 DOI: 10.1016/j.jneumeth.2006.07.028  0.48
2006 Xiong G, Zhou X, Degterev A, Ji L, Wong ST. Automated neurite labeling and analysis in fluorescence microscopy images. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 69: 494-505. PMID 16680708 DOI: 10.1002/cyto.a.20296  0.48
2006 Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. The Journal of Biological Chemistry. 281: 14474-85. PMID 16522639 DOI: 10.1074/jbc.M600364200  0.48
2005 Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chemical Biology. 1: 112-9. PMID 16408008 DOI: 10.1038/nchembio711  0.48
2005 Teng X, Degterev A, Jagtap P, Xing X, Choi S, Denu R, Yuan J, Cuny GD. Structure-activity relationship study of novel necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 5039-44. PMID 16153840 DOI: 10.1016/j.bmcl.2005.07.077  0.48
2005 Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Corrigendum: Chemical Inhibitor of Nonapoptotic Cell Death With Therapeutic Potential for Ischemic Brain Injury Nature Chemical Biology. 1: 234. DOI: 10.1038/nchembio0905-234a  0.48
2004 Boyce M, Degterev A, Yuan J. Caspases: An ancient cellular sword of Damocles Cell Death and Differentiation. 11: 29-37. PMID 14647235 DOI: 10.1038/sj.cdd.4401339  0.48
2003 Degterev A, Boyce M, Yuan J. A decade of caspases. Oncogene. 22: 8543-67. PMID 14634618 DOI: 10.1038/sj.onc.1207107  0.48
2003 Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death Neuron. 40: 401-413. PMID 14556717 DOI: 10.1016/S0896-6273(03)00601-9  0.48
2002 Lugovskoy AA, Degterev AI, Fahmy AF, Zhou P, Gross JD, Yuan J, Wagner G. A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. Journal of the American Chemical Society. 124: 1234-40. PMID 11841292 DOI: 10.1021/ja011239y  0.48
2001 Degterev A, Boyce M, Yuan J. The channel of death Journal of Cell Biology. 155: 695-697. PMID 11724809 DOI: 10.1083/jcb.200110147  0.48
2001 Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL Nature Cell Biology. 3: 173-182. PMID 11175750 DOI: 10.1038/35055085  0.48
1999 Degterev A, Yuan J. A new savior for neurons Nature Neuroscience. 2: 930-932. PMID 10526325 DOI: 10.1038/14712  0.48
1999 Degterev A, Foster JA. The role of NF-1 factors in regulation of elastin gene transcription. Matrix Biology : Journal of the International Society For Matrix Biology. 18: 295-307. PMID 10429948 DOI: 10.1016/S0945-053X(99)00020-7  0.48
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