Megan L. Matthews, Ph.D. - Publications

2017- Chemistry University of Pennsylvania, Philadelphia, PA, United States 
Chemical Biology, Analytical Chemistry, Proteomics, Enzymology

22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pan J, Wenger ES, Matthews ML, Pollock CJ, Bhardwaj M, Kim AJ, Allen BD, Grossman RB, Krebs C, Bollinger JM. Evidence for Modulation of Oxygen-Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxoglutarate-Dependent Oxygenases. Journal of the American Chemical Society. PMID 31475820 DOI: 10.1021/jacs.9b06689  1
2018 Blaesi EJ, Palowitch GM, Hu K, Kim AJ, Rose HR, Alapati R, Lougee MG, Kim HJ, Taguchi AT, Tan KO, Laremore TN, Griffin RG, Krebs C, Matthews ML, Silakov A, et al. Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical. Proceedings of the National Academy of Sciences of the United States of America. PMID 30224458 DOI: 10.1073/pnas.1811993115  1
2017 Martinie RJ, Pollock CJ, Matthews ML, Bollinger JM, Krebs C, Silakov A. Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes. Inorganic Chemistry. 56: 13382-13389. PMID 28960972 DOI: 10.1021/acs.inorgchem.7b02113  1
2017 Kornahrens AF, Cognetta AB, Brody DM, Matthews ML, Cravatt BF, Boger DL. Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor. Journal of the American Chemical Society. PMID 28498651 DOI: 10.1021/jacs.7b02985  1
2017 Matthews ML, He L, Horning BD, Olson EJ, Correia BE, Yates JR, Dawson PE, Cravatt BF. Chemoproteomic profiling and discovery of protein electrophiles in human cells. Nature Chemistry. 9: 234-243. PMID 28221344 DOI: 10.1038/nchem.2645  1
2016 Horning BD, Suciu RM, Ghadiri DA, Ulanovskaya OA, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H, Cravatt BF. Chemical Proteomic Profiling of Human Methyltransferases. Journal of the American Chemical Society. PMID 27689866 DOI: 10.1021/jacs.6b07830  1
2016 Srnec M, Wong SD, Matthews ML, Krebs C, Bollinger JM, Solomon EI. Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity. Journal of the American Chemical Society. 138: 5110-22. PMID 27021969 DOI: 10.1021/jacs.6b01151  1
2015 Bollinger JM, Chang WC, Matthews ML, Martinie RJ, Boal AK, Krebs C. Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond Rsc Metallobiology. 2015: 95-122. DOI: 10.1039/9781782621959-00095  1
2014 Rajagopalan S, Wang C, Yu K, Kuzin AP, Richter F, Lew S, Miklos AE, Matthews ML, Seetharaman J, Su M, Hunt JF, Cravatt BF, Baker D. Design of activated serine-containing catalytic triads with atomic-level accuracy. Nature Chemical Biology. 10: 386-91. PMID 24705591 DOI: 10.1038/nchembio.1498  1
2014 Matthews ML, Chang WC, Layne AP, Miles LA, Krebs C, Bollinger JM. Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase. Nature Chemical Biology. 10: 209-15. PMID 24463698 DOI: 10.1038/nchembio.1438  1
2013 Krebs C, Dassama LM, Matthews ML, Jiang W, Price JC, Korboukh V, Li N, Bollinger JM. Novel Approaches for the Accumulation of Oxygenated Intermediates to Multi-Millimolar Concentrations. Coordination Chemistry Reviews. 257. PMID 24368870 DOI: 10.1016/j.ccr.2012.06.020  1
2013 Wong SD, Srnec M, Matthews ML, Liu LV, Kwak Y, Park K, Bell CB, Alp EE, Zhao J, Yoda Y, Kitao S, Seto M, Krebs C, Bollinger JM, Solomon EI. Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2. Nature. 499: 320-3. PMID 23868262 DOI: 10.1038/nature12304  1
2012 Chang JW, Niphakis MJ, Lum KM, Cognetta AB, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH, Cravatt BF. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chemistry & Biology. 19: 579-88. PMID 22542104 DOI: 10.1016/j.chembiol.2012.03.009  1
2010 Hollenhorst MA, Bumpus SB, Matthews ML, Bollinger JM, Kelleher NL, Walsh CT. The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. Journal of the American Chemical Society. 132: 15773-81. PMID 20945916 DOI: 10.1021/ja1072367  1
2010 Bollinger JM, Matthews ML. Biochemistry. Remote enzyme microsurgery. Science (New York, N.Y.). 327: 1337-8. PMID 20223975 DOI: 10.1126/science.1187421  1
2009 Matthews ML, Neumann CS, Miles LA, Grove TL, Booker SJ, Krebs C, Walsh CT, Bollinger JM. Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2. Proceedings of the National Academy of Sciences of the United States of America. 106: 17723-8. PMID 19815524 DOI: 10.1073/pnas.0909649106  1
2009 Matthews ML, Krest CM, Barr EW, Vaillancourt FH, Walsh CT, Green MT, Krebs C, Bollinger JM. Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2. Biochemistry. 48: 4331-43. PMID 19245217 DOI: 10.1021/bi900109z  1
2009 Bollinger JM, Diao Y, Matthews ML, Xing G, Krebs C. myo-Inositol oxygenase: a radical new pathway for O(2) and C-H activation at a nonheme diiron cluster. Dalton Transactions (Cambridge, England : 2003). 905-14. PMID 19173070 DOI: 10.1039/b811885j  1
2007 Fujimori DG, Barr EW, Matthews ML, Koch GM, Yonce JR, Walsh CT, Bollinger JM, Krebs C, Riggs-Gelasco PJ. Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the alpha-ketoglutarate-dependent halogenase CytC3 from Streptomyces. Journal of the American Chemical Society. 129: 13408-9. PMID 17939667 DOI: 10.1021/ja076454e  1
2007 Krebs C, Matthews ML, Jiang W, Bollinger JM. AurF from Streptomyces thioluteus and a possible new family of manganese/iron oxygenases. Biochemistry. 46: 10413-8. PMID 17718517 DOI: 10.1021/bi701060g  1
2006 Matthews ML, Periyannan G, Hajdin C, Sidgel TK, Bennett B, Crowder MW. Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme Journal of the American Chemical Society. 128: 13050-13051. PMID 17017774 DOI: 10.1021/ja0627343  1
2005 Breece RM, Costello A, Bennett B, Sigdel TK, Matthews ML, Tierney DL, Crowder MW. A five-coordinate metal center in Co(II)-substituted VanX. The Journal of Biological Chemistry. 280: 11074-81. PMID 15657055 DOI: 10.1074/jbc.M412582200  1
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