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Mark J. Mitton-Fry, Ph.D. - Publications

Affiliations: 
2002 University of Colorado, Boulder, Boulder, CO, United States 
Area:
Organic Chemistry, Pharmaceutical Chemistry
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20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Phelps HA, Kuhn M, Lu Y, Vibhute S, Watts JL, Mitton-Fry MJ. Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens. Veterinary Microbiology. 284: 109840. PMID 37531840 DOI: 10.1016/j.vetmic.2023.109840  0.308
2022 Mohammed S, West JS, Mitton-Fry MJ. Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds. Synopen (2017). 6: 110-131. PMID 37206085 DOI: 10.1055/a-1826-2852  0.411
2021 Lu Y, Vibhute S, Li L, Okumu A, Ratigan SC, Nolan S, Papa JL, Mann CA, English A, Chen A, Seffernick JT, Koci B, Duncan LR, Roth B, Cummings JE, ... ... Mitton-Fry MJ, et al. Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with Efficacy against MRSA. Journal of Medicinal Chemistry. PMID 34614347 DOI: 10.1021/acs.jmedchem.1c01250  0.319
2020 Lu Y, Papa JL, Nolan S, English A, Seffernick JT, Shkolnikov N, Powell J, Lindert S, Wozniak DJ, Yalowich J, Mitton-Fry MJ. Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive . Acs Medicinal Chemistry Letters. 11: 2446-2454. PMID 33335666 DOI: 10.1021/acsmedchemlett.0c00428  0.332
2020 Okumu A, Lu Y, Dellos-Nolan S, Papa JL, Koci B, Cockroft NT, Gallucci J, Wozniak DJ, Yalowich JC, Mitton-Fry MJ. Novel bacterial topoisomerase inhibitors derived from isomannide. European Journal of Medicinal Chemistry. 199: 112324. PMID 32402932 DOI: 10.1016/J.Ejmech.2020.112324  0.453
2019 Li L, Okumu AA, Nolan S, English A, Vibhute S, Lu Y, Hervert-Thomas K, Seffernick J, Azap L, Cole SL, Shinabarger D, Koeth L, Lindert S, Yalowich J, Wozniak DJ, ... Mitton-Fry MJ, et al. 1,3-Dioxane-linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition. Acs Infectious Diseases. PMID 31041863 DOI: 10.1021/Acsinfecdis.8B00375  0.411
2018 Li L, Okumu A, Dellos-Nolan S, Li Z, Karmahapatra S, English A, Yalowich JC, Wozniak DJ, Mitton-Fry MJ. Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety. Bioorganic & Medicinal Chemistry Letters. PMID 29871847 DOI: 10.1016/J.Bmcl.2018.06.003  0.481
2018 Vazquez ML, Kaila N, Strohbach JW, Trzupek JD, Brown MF, Flanagan ME, MItton-Fry MJ, Johnson TA, TenBrink RE, Arnold EP, Basak A, Heasley SE, Kwon S, Langille J, Parikh MD, et al. Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. Journal of Medicinal Chemistry. PMID 29298069 DOI: 10.1021/Acs.Jmedchem.7B01598  0.31
2018 Lall MS, Tao Y, Arcari JT, Boyles DC, Brown MF, Damon DB, Lilley SC, Mitton-Fry MJ, Starr J, Stewart AM, Sun J. Process Development for the Synthesis of Monocyclic β-Lactam Core 17 Organic Process Research & Development. 22: 212-218. DOI: 10.1021/Acs.Oprd.7B00359  0.46
2017 Mitton-Fry MJ, Brickner SJ, Hamel JC, Barham R, Brennan L, Casavant JM, Ding X, Finegan S, Hardink J, Hoang T, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, et al. Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV. Bioorganic & Medicinal Chemistry Letters. PMID 28610977 DOI: 10.1016/J.Bmcl.2017.06.009  0.417
2013 Brown MF, Mitton-Fry MJ, Arcari JT, Barham R, Casavant J, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Lall MS, Lemmon MM, Li C, Lin J, et al. Pyridone-conjugated monobactam antibiotics with gram-negative activity. Journal of Medicinal Chemistry. 56: 5541-52. PMID 23755848 DOI: 10.1021/Jm400560Z  0.407
2013 Mitton-Fry MJ, Brickner SJ, Hamel JC, Brennan L, Casavant JM, Chen M, Chen T, Ding X, Driscoll J, Hardink J, Hoang T, Hua E, Huband MD, Maloney M, Marfat A, et al. Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV. Bioorganic & Medicinal Chemistry Letters. 23: 2955-61. PMID 23566517 DOI: 10.1016/J.Bmcl.2013.03.047  0.398
2012 McAllister LA, Montgomery JI, Abramite JA, Reilly U, Brown MF, Chen JM, Barham RA, Che Y, Chung SW, Menard CA, Mitton-Fry M, Mullins LM, Noe MC, O'Donnell JP, Oliver RM, et al. Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents. Bioorganic & Medicinal Chemistry Letters. 22: 6832-8. PMID 23046961 DOI: 10.1016/J.Bmcl.2012.09.058  0.7
2012 Mitton-Fry MJ, Arcari JT, Brown MF, Casavant JM, Finegan SM, Flanagan ME, Gao H, George DM, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Irvine R, et al. Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections. Bioorganic & Medicinal Chemistry Letters. 22: 5989-94. PMID 22892121 DOI: 10.1016/J.Bmcl.2012.07.005  0.401
2012 Montgomery JI, Brown MF, Reilly U, Price LM, Abramite JA, Arcari J, Barham R, Che Y, Chen JM, Chung SW, Collantes EM, Desbonnet C, Doroski M, Doty J, Engtrakul JJ, ... ... Mitton-Fry M, et al. Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections. Journal of Medicinal Chemistry. 55: 1662-70. PMID 22257165 DOI: 10.1021/Jm2014875  0.707
2012 Le TQ, Oliver RM, Arcari JT, Mitton-Fry MJ. Total synthesis of (±)-monomorine Tetrahedron Letters. 53: 5660-5662. DOI: 10.1016/J.Tetlet.2012.08.041  0.364
2011 Flanagan ME, Brickner SJ, Lall M, Casavant J, Deschenes L, Finegan SM, George DM, Granskog K, Hardink JR, Huband MD, Hoang T, Lamb L, Marra A, Mitton-Fry M, Mueller JP, et al. Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols. Acs Medicinal Chemistry Letters. 2: 385-90. PMID 24900319 DOI: 10.1021/Ml200012F  0.45
2011 Zhang Y, Arpin CC, Cullen AJ, Mitton-Fry MJ, Sammakia T. Total synthesis of dermostatin A. The Journal of Organic Chemistry. 76: 7641-53. PMID 21827209 DOI: 10.1021/Jo2012658  0.539
2009 Munchhof MJ, Antipas AS, Blumberg LC, Brissette WH, Brown MF, Casavant JM, Doty JL, Driscoll J, Harris TM, Wolf-Gouveia LA, Jones CS, Li Q, Linde RG, Lira PD, Marfat A, ... ... Mitton-Fry M, et al. The identification of orally bioavailable thrombopoietin agonists. Bioorganic & Medicinal Chemistry Letters. 19: 1428-30. PMID 19186055 DOI: 10.1016/J.Bmcl.2009.01.032  0.363
2007 Mitton-Fry MJ, Cullen AJ, Sammakia T. The total synthesis of the oxopolyene macrolide RK-397. Angewandte Chemie (International Ed. in English). 46: 1066-70. PMID 17051569 DOI: 10.1002/Anie.200602601  0.72
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