William Guerrant, Ph.D. - Related publications

2012 Georgia Institute of Technology, Atlanta, GA 
Biochemistry, Pharmaceutical Chemistry, Oncology
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Nagy MI, Darwish KM, Kishk SM, Tantawy MA, Nasr AM, Qushawy M, Swidan SA, Mostafa SM, Salama I. Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein. Pharmaceuticals (Basel, Switzerland). 14. PMID 33535550 DOI: 10.3390/ph14020113   
2021 Nicolaou KC, Rekula SR, Kumar SM, Podilapu AR, Matuszak RP, Jung PM, Lam LT, Phillips AC, Lyssikatos J, Munneke S, Gu C, Sarvaiya H, Sandoval J, Hammond M, Aujay M, et al. Design, Synthesis, and Biological Investigation of Thailanstatin A and Spliceostatin D Analogues Containing Tetrahydropyran, Tetrahydrooxazine, and Fluorinated Structural Motifs. The Journal of Organic Chemistry. PMID 33417458 DOI: 10.1021/acs.joc.0c02643   
2021 Lawal B, Liu YL, Mokgautsi N, Khedkar H, Sumitra MR, Wu ATH, Huang HS. Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines. Biomedicines. 9. PMID 33477856 DOI: 10.3390/biomedicines9010092   
2021 Anh DT, Hai PT, Huy LD, Ngoc HB, Ngoc TTM, Dung DTM, Park EJ, Song IK, Kang JS, Kwon JH, Tung TT, Han SB, Nam NH. Novel 4-Oxoquinazoline-Based -Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation. Acs Omega. 6: 4907-4920. PMID 33644598 DOI: 10.1021/acsomega.0c05870   
2021 Hao EJ, Li GX, Liang YR, Xie MS, Wang DC, Jiang XH, Cheng JY, Shi ZX, Wang Y, Guo HM. Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents and . Journal of Medicinal Chemistry. PMID 33538581 DOI: 10.1021/acs.jmedchem.0c01717   
2021 Liang X, Tang S, Liu X, Liu Y, Xu Q, Wang X, Saidahmatov A, Li C, Wang J, Zhou Y, Zhang Y, Geng M, Huang M, Liu H. Discovery of Novel Pyrrolo[2,3-]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors. Journal of Medicinal Chemistry. PMID 33586434 DOI: 10.1021/acs.jmedchem.0c02111   
2021 El-Sattar NEAA, Badawy EHK, AbdEl-Hady WH, Abo-Alkasem MI, Mandour AA, Ismail NSM. Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity. Chemical & Pharmaceutical Bulletin. 69: 106-117. PMID 33390512 DOI: 10.1248/cpb.c20-00714   
2021 Selas A, Martin-Encinas E, Fuertes M, Masdeu C, Rubiales G, Palacios F, Alonso C. A patent review of topoisomerase I inhibitors (2016-present). Expert Opinion On Therapeutic Patents. PMID 33475439 DOI: 10.1080/13543776.2021.1879051   
2021 Giardina SF, Valdambrini E, Warren JD, Barany F. PROTACs: Promising Approaches for Epigenetic Strategies to Overcome Drug Resistance. Current Cancer Drug Targets. PMID 33535953 DOI: 10.2174/1568009621666210203110857   
2021 Giardina SF, Valdambrini E, Warren JD, Barany F. PROTACs: Promising Approaches for Epigenetic Strategies to Overcome Drug Resistance. Current Cancer Drug Targets. PMID 33535953 DOI: 10.2174/1568009621666210203110857   
2021 Zehtabcheh S, Yousefi AM, Salari S, Safa M, Momeny M, Ghaffari SH, Bashash D. Abrogation of histone deacetylases (HDACs) decreases survival of chronic myeloid leukemia cells: new insight into attenuating effects of the PI3K/c-Myc axis on panobinostat cytotoxicity. Cell Biology International. PMID 33501756 DOI: 10.1002/cbin.11557   
2021 van de Merbel AF, van Hooij O, van der Horst G, van Rijt-van de Westerlo CCM, van der Mark MH, Cheung H, Kroon J, Verhaegh GW, Tijhuis J, Wellink A, Maas P, Viëtor H, Schalken JA, van der Pluijm G. The Identification of Small Molecule Inhibitors That Reduce Invasion and Metastasis of Aggressive Cancers. International Journal of Molecular Sciences. 22. PMID 33567533 DOI: 10.3390/ijms22041688   
2021 Aziz MA, Sarwar MS, Akter T, Uddin MS, Xun S, Zhu Y, Islam MS, Hongjie Z. Polyphenolic molecules targeting signal transducer and activator of transcription 3 pathway for the treatment of cancer. Life Sciences. 118999. PMID 33421525 DOI: 10.1016/j.lfs.2020.118999   
2021 Lin S, Liang Y, Cheng J, Pan F, Wang Y. Novel diaryl-2H-azirines: Antitumor hybrids for dual-targeting tubulin and DNA. European Journal of Medicinal Chemistry. 214: 113256. PMID 33581556 DOI: 10.1016/j.ejmech.2021.113256   
2021 Machalz D, Li H, Du W, Sharma S, Liu S, Bureik M, Wolber G. Discovery of a novel potent cytochrome P450 CYP4Z1 inhibitor. European Journal of Medicinal Chemistry. 215: 113255. PMID 33611185 DOI: 10.1016/j.ejmech.2021.113255   
2021 Jin F, Hu Q, Fei H, Lv H, Wang S, Gui B, Zhang J, Tu W, Zhang Y, Zhang L, Wan H, Zhang L, Hu B, Yang F, Bai C, et al. Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors. Acs Medicinal Chemistry Letters. 12: 195-201. PMID 33603965 DOI: 10.1021/acsmedchemlett.0c00443   
2021 Zhang Y, Rong D, Li B, Wang Y. Targeting Epigenetic Regulators with Covalent Small-Molecule Inhibitors. Journal of Medicinal Chemistry. PMID 33599482 DOI: 10.1021/acs.jmedchem.0c02055   
2021 Elhady SS, Abdelhameed RFA, El-Ayouty MM, Ibrahim AK, Habib ES, Elgawish MS, Hassanean HA, Safo MK, Nafie MS, Ahmed SA. New Antiproliferative Triflavanone from -Isolation, Structure Elucidation and Molecular Docking Studies. Molecules (Basel, Switzerland). 26. PMID 33572651 DOI: 10.3390/molecules26030739   
2021 Liu Q, Liu Z, Hua W, Gou S. Discovery of 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol Derivatives as Glutathione Transferase Inhibitors with Favorable Selectivity and Tolerated Toxicity. Journal of Medicinal Chemistry. PMID 33529017 DOI: 10.1021/acs.jmedchem.0c02048   
2021 Xu QQ, Zhang C, Zhang YL, Lei JL, Kong LY, Luo JG. Dimeric guaianes from leaves of Xylopia vielana as snail inhibitors identified by high content screening. Bioorganic Chemistry. 108: 104646. PMID 33484941 DOI: 10.1016/j.bioorg.2021.104646   
2021 Ghorab MM, Abdel-Kader MS, Alqahtani AS, Soliman AM. Synthesis of some quinazolinones inspired from the natural alkaloid Lnorephedrine as EGFR inhibitors and radiosensitizers. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 218-237. PMID 33357002 DOI: 10.1080/14756366.2020.1854243   
2021 Zhong Y, Liu J, Cheng X, Zhang H, Zhang C, Xia Z, Wu Z, Zhang L, Zheng Y, Gao Z, Jiang Z, Wang Z, Huang D, Lu Y, Jiang F. Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors. Bioorganic Chemistry. 109: 104736. PMID 33640630 DOI: 10.1016/j.bioorg.2021.104736   
2021 Sun S, Zhao W, Li Y, Chi Z, Fang X, Wang Q, Han Z, Luan Y. Design, synthesis and antitumor activity evaluation of novel HDAC inhibitors with tetrahydrobenzothiazole as the skeleton. Bioorganic Chemistry. 108: 104652. PMID 33497873 DOI: 10.1016/j.bioorg.2021.104652   
2021 Zhang J, Chen P, Duan Y, Xiong H, Li H, Zeng Y, Liang G, Tang Q, Wu D. Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidine derivatives containing 1,8-naphthyridine-4-one fragment. European Journal of Medicinal Chemistry. 215: 113273. PMID 33601310 DOI: 10.1016/j.ejmech.2021.113273   
2021 Danish D, Subbarao N, Khan M, Alouffi S, Khan S. New framework for the discovery of PRC2 inhibitors: Epigenetic Drugs. Current Drug Targets. PMID 33588726 DOI: 10.2174/1389450122666210215111744   
2021 Song R, Qiao W, He J, Huang J, Luo Y, Yang T. Proteases and Their Modulators in Cancer Therapy: Challenges and Opportunities. Journal of Medicinal Chemistry. PMID 33656892 DOI: 10.1021/acs.jmedchem.0c01640   
2021 Wu TB, Xiang QP, Wang C, Wu C, Zhang C, Zhang MF, Liu ZX, Zhang Y, Xiao LJ, Xu Y. Y06014 is a selective BET inhibitor for the treatment of prostate cancer. Acta Pharmacologica Sinica. PMID 33654218 DOI: 10.1038/s41401-021-00614-7   
2021 Sundaram MK, R P, Haque S, Akhter N, Khan S, Ahmed S, Hussain A. Dietary Isothiocyanates Inhibit Cancer Progression by Modulation of Epigenome. Seminars in Cancer Biology. PMID 33434642 DOI: 10.1016/j.semcancer.2020.12.021   
2021 Yang T, Wang P, Yin X, Zhang J, Huo M, Gao J, Li G, Teng X, Yu H, Huang W, Wang Y. The histone deacetylase inhibitor PCI-24781 impairs calcium influx and inhibits proliferation and metastasis in breast cancer. Theranostics. 11: 2058-2076. PMID 33500709 DOI: 10.7150/thno.48314   
2021 He S, Liu Y, Li Q, Lyu W, Feng F, Guo Q, Zhao L, Sun H. approaches using pharmacophore model combined with molecular docking for discovery of novel ULK1 inhibitors. Future Medicinal Chemistry. PMID 33427493 DOI: 10.4155/fmc-2020-0253   
2021 Zhou BD, Wei RR, Li JL, Yu ZH, Weng ZM, Ruan ZP, Lin J, Fang YY, Xu GF, Hu DB. Synthesis and antitumor activity of benzophenone compound. Journal of Asian Natural Products Research. 1-9. PMID 33583279 DOI: 10.1080/10286020.2021.1886090   
2021 Yan W, Zhang L, Lv F, Moccia M, Carlomagno F, Landry C, Santoro M, Gosselet F, Frett B, Li HY. Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation. European Journal of Medicinal Chemistry. 216: 113265. PMID 33652352 DOI: 10.1016/j.ejmech.2021.113265   
2021 Zhang J, Tan Y, Li G, Chen L, Nie M, Wang Z, Ji H. Coumarin Sulfonamides and Amides Derivatives: Design, Synthesis, and Antitumor Activity In Vitro. Molecules (Basel, Switzerland). 26. PMID 33546294 DOI: 10.3390/molecules26040786   
2021 Lin T, Li J, Liu L, Li Y, Jiang H, Chen K, Xu P, Luo C, Zhou B. Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors. European Journal of Medicinal Chemistry. 215: 113281. PMID 33611192 DOI: 10.1016/j.ejmech.2021.113281   
2021 Panneerpandian P, Ganesan K. Development of a cell-based pathway modulator screening system to screen the targeted cancer therapeutic candidates. Human Cell. PMID 33405176 DOI: 10.1007/s13577-020-00476-x   
2021 Liu Q, Luo Y, Li Z, Chen C, Fang L. Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity. Bioorganic & Medicinal Chemistry. 36: 116094. PMID 33667898 DOI: 10.1016/j.bmc.2021.116094   
2021 Chang X, Sun D, Shi D, Wang G, Chen Y, Zhang K, Tan H, Liu J, Liu B, Ouyang L. Design, synthesis, and biological evaluation of quinazolin-4(3)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy. Acta Pharmaceutica Sinica. B. 11: 156-180. PMID 33532187 DOI: 10.1016/j.apsb.2020.06.003   
2021 Wang R, Liu H, You YY, Wang XY, Lv BB, Cao LQ, Xue JY, Xu YG, Shi L. Discovery of novel VEGFR-2 inhibitors embedding 6,7-dimethoxyquinazoline and diarylamide fragments. Bioorganic & Medicinal Chemistry Letters. 127788. PMID 33460739 DOI: 10.1016/j.bmcl.2021.127788   
2021 Hu J, Zhang Y, Tang N, Lu Y, Guo P, Huang Z. Discovery of novel 1,3,5-triazine derivatives as potent inhibitor of cervical cancer via dual inhibition of PI3K/mTOR. Bioorganic & Medicinal Chemistry. 32: 115997. PMID 33440319 DOI: 10.1016/j.bmc.2021.115997   
2021 Hu J, Zhang Y, Tang N, Lu Y, Guo P, Huang Z. Discovery of novel 1,3,5-triazine derivatives as potent inhibitor of cervical cancer via dual inhibition of PI3K/mTOR. Bioorganic & Medicinal Chemistry. 32: 115997. PMID 33440319 DOI: 10.1016/j.bmc.2021.115997   
2021 Giang Nguyen Thi Q, Le-Nhat-Thuy G, Anh Dang Thi T, Hoang Thi P, Nguyen Tuan A, Ha Nguyen Thi T, Tra Nguyen T, Nguyen Ha T, Hoang Mai H, Van Nguyen T. Synthesis Of Novel Potent Cytotoxicy Podophyllotoxin-Naphthoquinone Compounds via Microwave-Assited Multicomponent Domino Reactions. Bioorganic & Medicinal Chemistry Letters. 127841. PMID 33556568 DOI: 10.1016/j.bmcl.2021.127841   
2021 Lenci E, Cosottini L, Trabocchi A. Novel matrix metalloproteinase inhibitors: an updated patent review (2014 - 2020). Expert Opinion On Therapeutic Patents. PMID 33487088 DOI: 10.1080/13543776.2021.1881481   
2021 To KKW, Cho WCS. Flavonoids overcome drug resistance to cancer chemotherapy by epigenetically modulating multiple mechanisms. Current Cancer Drug Targets. PMID 33535954 DOI: 10.2174/1568009621666210203111220   
2021 Zhang Y, Yu H, Fu S, Tan L, Liu J, Zhou B, Li L, Liu Y, Wang C, Li P, Liu J. Synthesis and Anti-Hepatocarcinoma Effect of Amino Acid Derivatives of Pyxinol and Ocotillol. Molecules (Basel, Switzerland). 26. PMID 33546225 DOI: 10.3390/molecules26040780   
2021 Henley MJ, Doyle SK, Koehler AN. Nailing Down a Notoriously Elusive Cancer Target: Direct Inhibition of MYC by a Covalent Small Molecule. Cell Chemical Biology. 28: 1-3. PMID 33482085 DOI: 10.1016/j.chembiol.2020.12.014   
2021 Qamar H, Hussain K, Soni A, Khan A, Hussain T, Chénais B. Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors. Molecules (Basel, Switzerland). 26. PMID 33466486 DOI: 10.3390/molecules26010247   
2021 Krzywik J, Aminpour M, Janczak J, Maj E, Moshari M, Mozga W, Wietrzyk J, Tuszyński JA, Huczyński A. An insight into the anticancer potential of carbamates and thiocarbamates of 10-demethoxy-10-methylaminocolchicine. European Journal of Medicinal Chemistry. 215: 113282. PMID 33611191 DOI: 10.1016/j.ejmech.2021.113282   
2021 Yoo J, Jeon YH, Lee DH, Kim GW, Lee SW, Kim SY, Park J, Kwon SH. HDAC6-selective inhibitors enhance anticancer effects of paclitaxel in ovarian cancer cells. Oncology Letters. 21: 201. PMID 33574940 DOI: 10.3892/ol.2021.12462   
2021 Hagras M, El Deeb MA, Elzahabi HSA, Elkaeed EB, Mehany ABM, Eissa IH. Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 640-658. PMID 33588683 DOI: 10.1080/14756366.2021.1883598   
2021 Komuraiah B, Ren Y, Xue M, Cheng B, Liu J, Liu Y, Chen J. Design, Synthesis and Biological Evaluation of Benz-Fused Five-Membered Heterocyclic Compounds as Tubulin Polymerization Inhibitors with Anticancer Activities. Chemical Biology & Drug Design. PMID 33638903 DOI: 10.1111/cbdd.13832