Varman T. Samuel, Ph.D. - Publications

Affiliations: 
2005 Yale University, New Haven, CT 
Area:
Medicine and Surgery

88 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Samuel VT, Petersen MC, Gassaway BM, Vatner DF, Rinehart J, Shulman GI. Considering the links between NAFLD and insulin resistance: revisiting the role of protein kinase c ε. Hepatology (Baltimore, Md.). PMID 31220350 DOI: 10.1002/hep.30829  0.84
2019 Abulizi A, Camporez JP, Jurczak MJ, Høyer KF, Zhang D, Cline GW, Samuel VT, Shulman GI, Vatner DF. Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802706R. PMID 30922125 DOI: 10.1096/fj.201802706R  0.84
2018 Abulizi A, Camporez JP, Zhang D, Samuel VT, Shulman GI, Vatner DF. Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-Hydroxysteroid dehydrogenase type 1 transgenic mice. Metabolism: Clinical and Experimental. PMID 30576689 DOI: 10.1016/j.metabol.2018.12.003  0.84
2018 Beddow SA, Gattu AK, Vatner DF, Paolella L, Alqarzaee A, Tashkandi N, Popov V, Church C, Rodeheffer M, Cline G, Geisler J, Bhanot S, Samuel VT. PEPCK1 antisense oligonucleotide prevents adiposity and impairs hepatic glycogen synthesis in high-fat male fed rats. Endocrinology. PMID 30445425 DOI: 10.1210/en.2018-00630  0.72
2018 Gassaway BM, Petersen MC, Surovtseva YV, Barber KW, Sheetz JB, Aerni HR, Merkel JS, Samuel VT, Shulman GI, Rinehart J. PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 30181290 DOI: 10.1073/pnas.1804379115  0.84
2018 Vatner DF, Goedeke L, Camporez JG, Lyu K, Nasiri AR, Zhang D, Bhanot S, Murray SF, Still CD, Gerhard GS, Shulman GI, Samuel VT. Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents. Diabetologia. PMID 29497783 DOI: 10.1007/s00125-018-4579-1  0.84
2017 Samuel VT, Shulman GI. Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. Cell Metabolism. PMID 28867301 DOI: 10.1016/j.cmet.2017.08.002  0.84
2017 Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ. Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans. Cell Reports. 19: 1997-2004. PMID 28591572 DOI: 10.1016/j.celrep.2017.05.035  0.84
2017 Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT. Mitochondrial Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation. Diabetes. PMID 28476930 DOI: 10.2337/db16-1334  0.84
2016 Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, et al. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. The Journal of Clinical Investigation. PMID 27760050 DOI: 10.1172/JCI86013  0.84
2016 Herman MA, Samuel VT. The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. Trends in Endocrinology and Metabolism: Tem. PMID 27387598 DOI: 10.1016/j.tem.2016.06.005  0.84
2016 Madiraju AK, Alves T, Zhao X, Cline GW, Zhang D, Bhanot S, Samuel VT, Kibbey RG, Shulman GI. Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 27247419 DOI: 10.1073/pnas.1606022113  0.84
2016 Samuel VT, Shulman GI. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. The Journal of Clinical Investigation. 126: 12-22. PMID 26727229 DOI: 10.1172/JCI77812  0.84
2015 Pesta DH, Perry RJ, Guebre-Egziabher F, Zhang D, Jurczak M, Fischer-Rosinsky A, Daniels MA, Willmes DM, Bhanot S, Bornstein SR, Knauf F, Samuel VT, Shulman GI, Birkenfeld AL. Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5). Aging. PMID 26647160  0.84
2015 Popov VB, Jornayvaz FR, Akgul EO, Kanda S, Jurczak MJ, Zhang D, Abudukadier A, Majumdar SK, Guigni B, Petersen KF, Manchem VP, Bhanot S, Shulman GI, Samuel VT. Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26644352 DOI: 10.1096/fj.15-271999  0.84
2015 Vatner DF, Snikeris J, Popov V, Perry RJ, Rahimi Y, Samuel VT. 3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats. Plos One. 10: e0140837. PMID 26485433 DOI: 10.1371/journal.pone.0140837  0.84
2015 Camporez JP, Asrih M, Zhang D, Kahn M, Samuel VT, Jurczak MJ, Jornayvaz FR. Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21. The Journal of Endocrinology. 226: 207-17. PMID 26203166 DOI: 10.1530/JOE-15-0136  0.84
2015 Habtemichael EN, Alcázar-Román A, Rubin BR, Grossi LR, Belman JP, Julca O, Löffler MG, Li H, Chi NW, Samuel VT, Bogan JS. Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle. The Journal of Biological Chemistry. 290: 14454-61. PMID 25944897 DOI: 10.1074/jbc.C115.639203  0.84
2015 Kliewer KL, Ke JY, Lee HY, Stout MB, Cole RM, Samuel VT, Shulman GI, Belury MA. Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice. The Journal of Nutritional Biochemistry. 26: 721-8. PMID 25913018 DOI: 10.1016/j.jnutbio.2015.01.010  0.84
2015 Vatner DF, Majumdar SK, Kumashiro N, Petersen MC, Rahimi Y, Gattu AK, Bears M, Camporez JP, Cline GW, Jurczak MJ, Samuel VT, Shulman GI. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. Proceedings of the National Academy of Sciences of the United States of America. 112: 1143-8. PMID 25564660 DOI: 10.1073/pnas.1423952112  0.84
2015 Camporez JP, Kanda S, Petersen MC, Jornayvaz FR, Samuel VT, Bhanot S, Petersen KF, Jurczak MJ, Shulman GI. ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content. Journal of Lipid Research. 56: 526-36. PMID 25548259 DOI: 10.1194/jlr.M054080  0.84
2015 Vatner DF, Majumdar SK, Kumashiro N, Petersen MC, Rahimi Y, Gattu AK, Bears M, Camporez JPG, Cline GW, Jurczak MJ, Samuel VT, Shulman GI. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids Proceedings of the National Academy of Sciences of the United States of America. 112: 1143-1148. DOI: 10.1073/pnas.1423952112  0.84
2014 Pesta DH, Samuel VT. A high-protein diet for reducing body fat: mechanisms and possible caveats. Nutrition & Metabolism. 11: 53. PMID 25489333 DOI: 10.1186/1743-7075-11-53  0.84
2014 Samuel VT. The emerging role of oestrogen-related receptor γ as a regulator of energy metabolism. Diabetologia. 57: 2440-3. PMID 25257097 DOI: 10.1007/s00125-014-3377-7  0.84
2014 Cantley JL, Vatner DF, Galbo T, Madiraju A, Petersen M, Perry RJ, Kumashiro N, Guebre-Egziabher F, Gattu AK, Stacy MR, Dione DP, Sinusas AJ, Ragolia L, Hall CE, Manchem VP, ... ... Samuel VT, et al. Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats. American Journal of Physiology. Endocrinology and Metabolism. 307: E773-83. PMID 25159329 DOI: 10.1152/ajpendo.00148.2014  0.84
2014 Perry RJ, Samuel VT, Petersen KF, Shulman GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 510: 84-91. PMID 24899308 DOI: 10.1038/nature13478  0.84
2014 Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 510: 542-6. PMID 24847880 DOI: 10.1038/nature13270  0.84
2014 Lee HY, Gattu AK, Camporez JP, Kanda S, Guigni B, Kahn M, Zhang D, Galbo T, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Choi CS, Yan Z, Williams RS, Shulman GI, ... Samuel VT, et al. Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia. 57: 1232-41. PMID 24718953 DOI: 10.1007/s00125-014-3212-1  0.84
2014 Gattu AK, Birkenfeld AL, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel VT, Crawford SE, Chung C. Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology. 155: 1373-85. PMID 24456163 DOI: 10.1210/en.2013-1785  0.84
2014 Wheeler SG, Hammond CL, Jornayvaz FR, Samuel VT, Shulman GI, Soroka CJ, Boyer JL, Hinkle PM, Ballatori N. Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity. American Journal of Physiology. Gastrointestinal and Liver Physiology. 306: G425-38. PMID 24381083 DOI: 10.1152/ajpgi.00368.2013  0.84
2013 Galbo T, Perry RJ, Nishimura E, Samuel VT, Quistorff B, Shulman GI. PP2A inhibition results in hepatic insulin resistance despite Akt2 activation. Aging. 5: 770-81. PMID 24150286  0.84
2013 Bays HE, Toth PP, Kris-Etherton PM, Abate N, Aronne LJ, Brown WV, Gonzalez-Campoy JM, Jones SR, Kumar R, La Forge R, Samuel VT. Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association. Journal of Clinical Lipidology. 7: 304-83. PMID 23890517 DOI: 10.1016/j.jacl.2013.04.001  0.84
2013 Gattu AK, Swenson ES, Iwakiri Y, Samuel VT, Troiano N, Berry R, Church CD, Rodeheffer MS, Carpenter TO, Chung C. Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 4384-94. PMID 23887690 DOI: 10.1096/fj.13-232900  0.84
2013 Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI. Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: 12780-5. PMID 23840067 DOI: 10.1073/pnas.1311176110  0.84
2013 Camporez JP, Jornayvaz FR, Petersen MC, Pesta D, Guigni BA, Serr J, Zhang D, Kahn M, Samuel VT, Jurczak MJ, Shulman GI. Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. Endocrinology. 154: 3099-109. PMID 23766126 DOI: 10.1210/en.2013-1191  0.84
2013 Löffler MG, Birkenfeld AL, Philbrick KM, Belman JP, Habtemichael EN, Booth CJ, Castorena CM, Choi CS, Jornayvaz FR, Gassaway BM, Lee HY, Cartee GD, Philbrick W, Shulman GI, Samuel VT, et al. Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle. The Journal of Biological Chemistry. 288: 20135-50. PMID 23744065 DOI: 10.1074/jbc.M113.458075  0.84
2013 Vatner DF, Weismann D, Beddow SA, Kumashiro N, Erion DM, Liao XH, Grover GJ, Webb P, Phillips KJ, Weiss RE, Bogan JS, Baxter J, Shulman GI, Samuel VT. Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways. American Journal of Physiology. Endocrinology and Metabolism. 305: E89-100. PMID 23651850 DOI: 10.1152/ajpendo.00573.2012  0.84
2013 Erion DM, Kotas ME, McGlashon J, Yonemitsu S, Hsiao JJ, Nagai Y, Iwasaki T, Murray SF, Bhanot S, Cline GW, Samuel VT, Shulman GI, Gillum MP. cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis. The Journal of Biological Chemistry. 288: 16167-76. PMID 23595987 DOI: 10.1074/jbc.M113.460246  0.84
2013 Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, ... ... Samuel VT, et al. Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance Diabetes. 62: 2183-2194. PMID 23423574 DOI: 10.2337/db12-1311  0.84
2013 Camporez JP, Jornayvaz FR, Lee HY, Kanda S, Guigni BA, Kahn M, Samuel VT, Carvalho CR, Petersen KF, Jurczak MJ, Shulman GI. Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology. 154: 1021-8. PMID 23364948 DOI: 10.1210/en.2012-1989  0.84
2013 Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, Guebre-Egziabher F, Jurczak MJ, Kahn M, Guigni BA, Serr J, Hankin J, Murphy RC, Cline GW, Bhanot S, ... ... Samuel VT, et al. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 110: 1869-74. PMID 23302688 DOI: 10.1073/pnas.1219456110  0.84
2013 Kumashiro N, Yoshimura T, Cantley JL, Majumdar SK, Guebre-Egziabher F, Kursawe R, Vatner DF, Fat I, Kahn M, Erion DM, Zhang XM, Zhang D, Manchem VP, Bhanot S, Gerhard GS, ... ... Samuel VT, et al. Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats Hepatology. 57: 1763-1772. PMID 23175050 DOI: 10.1002/hep.26170  0.84
2013 Erion DM, Popov V, Hsiao JJ, Vatner D, Mitchell K, Yonemitsu S, Nagai Y, Kahn M, Gillum MP, Dong J, Murray SF, Manchem VP, Bhanot S, Cline GW, Shulman GI, ... Samuel VT, et al. The role of the carbohydrate response element-binding protein in male fructose-fed rats Endocrinology. 154: 36-44. PMID 23161873 DOI: 10.1210/en.2012-1725  0.84
2013 Jin ES, Beddow SA, Malloy CR, Samuel VT. Hepatic glucose production pathways after three days of a high-fat diet. Metabolism: Clinical and Experimental. 62: 152-62. PMID 22981137 DOI: 10.1016/j.metabol.2012.07.012  0.84
2012 Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel VT, Cravatt BF, Diano S, Shulman GI. Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism. Proceedings of the National Academy of Sciences of the United States of America. 109: 14966-71. PMID 22912404 DOI: 10.1073/pnas.1212887109  0.84
2012 Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J, Yates JR, Yang X. O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability. Cell Metabolism. 16: 226-37. PMID 22883232 DOI: 10.1016/j.cmet.2012.07.006  0.84
2012 Beddow SA, Samuel VT. Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes. Disease Models & Mechanisms. 5: 681-5. PMID 22864022 DOI: 10.1242/dmm.009035  0.84
2012 Li X, Shan J, Chang W, Kim I, Bao J, Lee HJ, Zhang X, Samuel VT, Shulman GI, Liu D, Zheng JJ, Wu D. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 109: 11402-7. PMID 22733757 DOI: 10.1073/pnas.1205015109  0.84
2012 Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell. 148: 852-71. PMID 22385956 DOI: 10.1016/j.cell.2012.02.017  0.84
2012 Morino K, Petersen KF, Sono S, Choi CS, Samuel VT, Lin A, Gallo A, Zhao H, Kashiwagi A, Goldberg IJ, Wang H, Eckel RH, Maegawa H, Shulman GI. Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes. Diabetes. 61: 877-87. PMID 22368174 DOI: 10.2337/db11-1391  0.84
2012 Liu W, Singh R, Choi CS, Lee HY, Keramati AR, Samuel VT, Lifton RP, Shulman GI, Mani A. Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. The Journal of Biological Chemistry. 287: 7213-23. PMID 22232553 DOI: 10.1074/jbc.M111.286724  0.84
2012 Jornayvaz FR, Lee HY, Jurczak MJ, Alves TC, Guebre-Egziabher F, Guigni BA, Zhang D, Samuel VT, Silva JE, Shulman GI. Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance. Endocrinology. 153: 583-91. PMID 22147010 DOI: 10.1210/en.2011-1793  0.84
2012 Jurczak MJ, Lee AH, Jornayvaz FR, Lee HY, Birkenfeld AL, Guigni BA, Kahn M, Samuel VT, Glimcher LH, Shulman GI. Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. The Journal of Biological Chemistry. 287: 2558-67. PMID 22128176 DOI: 10.1074/jbc.M111.316760  0.84
2012 Li X, Shan J, Chang W, Kim I, Bao J, Lee HJ, Zhang X, Samuel VT, Shulman GI, Liu D, Zheng JJ, Wu D. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism (Proceedings of the National Academy of Sciences of the United States of America (2012) 109, 28 (11402-11407) DOI: 10.1073/pnas.1205015109) Proceedings of the National Academy of Sciences of the United States of America. 109: 17141. DOI: 10.1073/pnas.1215480109  0.84
2011 Banks AS, Kim-Muller JY, Mastracci TL, Kofler NM, Qiang L, Haeusler RA, Jurczak MJ, Laznik D, Heinrich G, Samuel VT, Shulman GI, Papaioannou VE, Accili D. Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metabolism. 14: 587-97. PMID 22055502 DOI: 10.1016/j.cmet.2011.09.012  0.84
2011 Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proceedings of the National Academy of Sciences of the United States of America. 108: 16381-5. PMID 21930939 DOI: 10.1073/pnas.1113359108  0.84
2011 Birkenfeld AL, Lee HY, Majumdar S, Jurczak MJ, Camporez JP, Jornayvaz FR, Frederick DW, Guigni B, Kahn M, Zhang D, Weismann D, Arafat AM, Pfeiffer AF, Lieske S, Oyadomari S, ... ... Samuel VT, et al. Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism. The Journal of Biological Chemistry. 286: 36163-70. PMID 21832042 DOI: 10.1074/jbc.M111.228817  0.84
2011 Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D. Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nature Medicine. 17: 961-7. PMID 21804540 DOI: 10.1038/nm.2378  0.84
2011 Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, ... ... Samuel VT, et al. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metabolism. 14: 184-95. PMID 21803289 DOI: 10.1016/j.cmet.2011.06.009  0.84
2011 Lee HY, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Kanda S, Popov V, Frederick DW, Zhang D, Guigni B, Bharadwaj KG, Choi CS, Goldberg IJ, Park JH, Petersen KF, Samuel VT, et al. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology (Baltimore, Md.). 54: 1650-60. PMID 21793029 DOI: 10.1002/hep.24571  0.84
2011 Ahmadian M, Abbott MJ, Tang T, Hudak CS, Kim Y, Bruss M, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Wang Y, Duncan RE, Kang C, Sul HS. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metabolism. 13: 739-48. PMID 21641555 DOI: 10.1016/j.cmet.2011.05.002  0.84
2011 Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science (New York, N.Y.). 331: 1621-4. PMID 21436455 DOI: 10.1126/science.1198363  0.84
2011 Jornayvaz FR, Birkenfeld AL, Jurczak MJ, Kanda S, Guigni BA, Jiang DC, Zhang D, Lee HY, Samuel VT, Shulman GI. Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proceedings of the National Academy of Sciences of the United States of America. 108: 5748-52. PMID 21436037 DOI: 10.1073/pnas.1103451108  0.84
2011 Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG. SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. Diabetes. 60: 890-8. PMID 21357472 DOI: 10.2337/db10-1328  0.84
2011 Perfield JW, Lee Y, Shulman GI, Samuel VT, Jurczak MJ, Chang E, Xie C, Tsichlis PN, Obin MS, Greenberg AS. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes. 60: 1168-76. PMID 21346175 DOI: 10.2337/db10-0715  0.84
2011 Lin HV, Ren H, Samuel VT, Lee HY, Lu TY, Shulman GI, Accili D. Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues. Diabetes. 60: 700-9. PMID 21266328 DOI: 10.2337/db10-1056  0.84
2011 Weismann D, Erion DM, Ignatova-Todorava I, Nagai Y, Stark R, Hsiao JJ, Flannery C, Birkenfeld AL, May T, Kahn M, Zhang D, Yu XX, Murray SF, Bhanot S, Monia BP, ... ... Samuel VT, et al. Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance Diabetologia. 54: 935-944. PMID 21190014 DOI: 10.1007/s00125-010-1984-5  0.84
2011 Samuel VT. Fructose induced lipogenesis: from sugar to fat to insulin resistance. Trends in Endocrinology and Metabolism: Tem. 22: 60-5. PMID 21067942 DOI: 10.1016/j.tem.2010.10.003  0.84
2011 Jornayvaz FR, Jurczak MJ, Samuel VT, Shulman GI. Reply to Monetti et al.: Hepatic steatosis and diacylglycerol-mediated hepatic insulin resistance in acyl-CoA:Diacylglycerol acyltransferase 2 (DGAT2) transgenic mice Proceedings of the National Academy of Sciences of the United States of America. 108. DOI: 10.1073/pnas.1109195108  0.84
2010 Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI. Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metabolism. 12: 668-74. PMID 21109199 DOI: 10.1016/j.cmet.2010.11.004  0.84
2010 Jornayvaz FR, Jurczak MJ, Lee HY, Birkenfeld AL, Frederick DW, Zhang D, Zhang XM, Samuel VT, Shulman GI. A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain. American Journal of Physiology. Endocrinology and Metabolism. 299: E808-15. PMID 20807839 DOI: 10.1152/ajpendo.00361.2010  0.84
2010 Ayala JE, Samuel VT, Morton GJ, Obici S, Croniger CM, Shulman GI, Wasserman DH, McGuinness OP. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Disease Models & Mechanisms. 3: 525-34. PMID 20713647 DOI: 10.1242/dmm.006239  0.84
2010 Jornayvaz FR, Samuel VT, Shulman GI. The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. Annual Review of Nutrition. 30: 273-90. PMID 20645852 DOI: 10.1146/annurev.nutr.012809.104726  0.84
2010 Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet (London, England). 375: 2267-77. PMID 20609972 DOI: 10.1016/S0140-6736(10)60408-4  0.84
2010 Chutkow WA, Birkenfeld AL, Brown JD, Lee HY, Frederick DW, Yoshioka J, Patwari P, Kursawe R, Cushman SW, Plutzky J, Shulman GI, Samuel VT, Lee RT. Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes. 59: 1424-34. PMID 20299477 DOI: 10.2337/db09-1212  0.84
2009 Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, ... ... Samuel VT, et al. Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein Cell Metabolism. 10: 499-506. PMID 19945407 DOI: 10.1016/j.cmet.2009.10.007  0.84
2009 Roth RJ, Le AM, Zhang L, Kahn M, Samuel VT, Shulman GI, Bennett AM. MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. The Journal of Clinical Investigation. 119: 3817-29. PMID 19920356 DOI: 10.1172/JCI39054  0.84
2009 Samuel VT, Beddow SA, Iwasaki T, Zhang XM, Chu X, Still CD, Gerhard GS, Shulman GI. Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes. Proceedings of the National Academy of Sciences of the United States of America. 106: 12121-6. PMID 19587243 DOI: 10.1073/pnas.0812547106  0.84
2009 Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, ... Samuel VT, et al. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proceedings of the National Academy of Sciences of the United States of America. 106: 11288-93. PMID 19549853 DOI: 10.1073/pnas.0812931106  0.84
2009 Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nature Medicine. 15: 159-68. PMID 19136964 DOI: 10.1038/nm.1904  0.84
2009 Ahmadian M, Duncan RE, Varady KA, Frasson D, Hellerstein MK, Birkenfeld AL, Samuel VT, Shulman GI, Wang Y, Kang C, Sul HS. Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity. Diabetes. 58: 855-66. PMID 19136649 DOI: 10.2337/db08-1644  0.84
2009 Samuel VT, Petersen KF, Shulman GI. Insulin Resistance The Liver: Biology and Pathobiology: Fifth Edition. 469-483. DOI: 10.1002/9780470747919.ch31  0.84
2008 Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, et al. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 105: 19926-31. PMID 19066218 DOI: 10.1073/pnas.0810339105  0.84
2007 Cheol SC, Savage DB, Kulkarni A, Xing XY, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, et al. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance Journal of Biological Chemistry. 282: 22678-22688. PMID 17526931 DOI: 10.1074/jbc.M704213200  0.84
2007 Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, Kahn M, Zhang XM, Monia BP, Bhanot S, Shulman GI. Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. The Journal of Clinical Investigation. 117: 739-45. PMID 17318260 DOI: 10.1172/JCI30400  0.84
2006 Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM. Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action. Diabetes. 55: 2042-50. PMID 16804074 DOI: 10.2337/db05-0705  0.84
2006 Savage DB, Choi CS, Samuel VT, Liu ZX, Zhang D, Wang A, Zhang XM, Cline GW, Yu XX, Geisler JG, Bhanot S, Monia BP, Shulman GI. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. The Journal of Clinical Investigation. 116: 817-24. PMID 16485039 DOI: 10.1172/JCI27300  0.84
2004 Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. The Journal of Biological Chemistry. 279: 32345-53. PMID 15166226 DOI: 10.1074/jbc.M313478200  0.84
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