| Year |
Citation |
Score |
| 2021 |
Zhang X, Sakamoto W, Canals D, Ishibashi M, Matsuda M, Nishida K, Toyoshima M, Shigeta S, Taniguchi M, Senkal CE, Okazaki T, Yaegashi N, Hannun YA, Nabe T, Kitatani K. Ceramide synthase 2-C -ceramide axis limits the metastatic potential of ovarian cancer cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21287. PMID 33423335 DOI: 10.1096/fj.202001504RR |
0.407 |
|
| 2017 |
Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, Nganga R, Thomas RJ, Senkal CE, Howe PH, Ogretmen B. TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Science Signaling. 10. PMID 29066540 DOI: 10.1126/Scisignal.Aam7464 |
0.755 |
|
| 2015 |
Hernández-Corbacho MJ, Canals D, Adada MM, Liu M, Senkal CE, Yi JK, Mao C, Luberto C, Hannun YA, Obeid LM. Tumor Necrosis Factor alpha (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. The Journal of Biological Chemistry. PMID 26318452 DOI: 10.1074/jbc.M115.658658 |
0.397 |
|
| 2014 |
Qin Z, Dai L, Trillo-Tinoco J, Senkal C, Wang W, Reske T, Bonstaff K, Del Valle L, Rodriguez P, Flemington E, Voelkel-Johnson C, Smith CD, Ogretmen B, Parsons C. Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Molecular Cancer Therapeutics. 13: 154-64. PMID 24140934 DOI: 10.1158/1535-7163.Mct-13-0466 |
0.703 |
|
| 2014 |
El Osta M, Liu M, Adada M, Senkal CE, Idkowiak-Baldys J, Obeid LM, Clarke CJ, Hannun YA. Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 495-505. PMID 24121461 DOI: 10.1096/Fj.13-230557 |
0.497 |
|
| 2013 |
Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, et al. Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. Embo Molecular Medicine. 5: 105-21. PMID 23180565 DOI: 10.1002/Emmm.201201283 |
0.76 |
|
| 2013 |
Qin Z, Dai L, Plaisance-Bonstaff K, Senkal C, Wang W, Reske TM, Del Valle L, Voelkel-Johnson C, Flemington E, Ogretmen B, Smith CD, Parsons C. Targeting Sphingosine Kinase Induces Apoptosis and Regression Of Virus-Associated Lymphoma In Vivo Blood. 122: 4414-4414. DOI: 10.1182/Blood.V122.21.4414.4414 |
0.681 |
|
| 2012 |
Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nature Chemical Biology. 8: 831-8. PMID 22922758 DOI: 10.1038/Nchembio.1059 |
0.733 |
|
| 2012 |
Meyers-Needham M, Ponnusamy S, Gencer S, Jiang W, Thomas RJ, Senkal CE, Ogretmen B. Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells. Embo Molecular Medicine. 4: 78-92. PMID 22180294 DOI: 10.1002/Emmm.201100189 |
0.618 |
|
| 2011 |
Simon GR, Saddoughi S, Mukhopadhyay A, Peterson Y, Senkal CE, Oaks J, Perrotti D, Hannun Y, Ogretmen B. Targeting I2PP2A by FTY720: A novel, mechanism-based treatment strategy for patients with advanced and previously treated non-small cell lung cancer (NSCLC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 7574. PMID 28023125 DOI: 10.1200/Jco.2011.29.15_Suppl.7574 |
0.769 |
|
| 2011 |
Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. The Journal of Biological Chemistry. 286: 42446-58. PMID 22013072 DOI: 10.1074/Jbc.M111.287383 |
0.782 |
|
| 2011 |
Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, et al. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum Câ‚₈-ceramide as a novel biomarker for monitoring response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6097-105. PMID 21791630 DOI: 10.1158/1078-0432.Ccr-11-0930 |
0.736 |
|
| 2011 |
Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, et al. Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 117: 5941-52. PMID 21527515 DOI: 10.1182/Blood-2010-08-300772 |
0.684 |
|
| 2011 |
Ogretmen B, Sentelle D, Senkal CE. Abstract 2875: Ceramide suffocates cancer cells to death: Regulation of mitophagy by ceramide signaling Cancer Research. 71: 2875-2875. DOI: 10.1158/1538-7445.Am2011-2875 |
0.72 |
|
| 2010 |
Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A, Ogretmen B. Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncology (London, England). 6: 1603-24. PMID 21062159 DOI: 10.2217/Fon.10.116 |
0.801 |
|
| 2010 |
Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B. Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 296-308. PMID 19723703 DOI: 10.1096/Fj.09-135087 |
0.691 |
|
| 2009 |
Patwardhan GA, Zhang QJ, Yin D, Gupta V, Bao J, Senkal CE, Ogretmen B, Cabot MC, Shah GV, Sylvester PW, Jazwinski SM, Liu YY. A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. Plos One. 4: e6938. PMID 19742320 DOI: 10.1371/Journal.Pone.0006938 |
0.652 |
|
| 2009 |
White-Gilbertson S, Mullen T, Senkal C, Lu P, Ogretmen B, Obeid L, Voelkel-Johnson C. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells Oncogene. 28: 1132-1141. PMID 19137010 DOI: 10.1038/Onc.2008.468 |
0.701 |
|
| 2009 |
Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B. Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 751-63. PMID 19028839 DOI: 10.1096/Fj.08-120550 |
0.788 |
|
| 2007 |
Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, Ogretmen B. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Letters. 256: 101-11. PMID 17619081 DOI: 10.1016/J.Canlet.2007.06.003 |
0.62 |
|
| 2007 |
Wooten-Blanks LG, Song P, Senkal CE, Ogretmen B. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3386-97. PMID 17548428 DOI: 10.1096/Fj.07-8621Com |
0.651 |
|
| 2007 |
Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B. Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Molecular Cancer Therapeutics. 6: 712-22. PMID 17308067 DOI: 10.1158/1535-7163.Mct-06-0558 |
0.7 |
|
| 2007 |
Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM, Ogretmen B. Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. The Journal of Biological Chemistry. 282: 10922-34. PMID 17303574 DOI: 10.1074/Jbc.M610157200 |
0.787 |
|
| 2006 |
Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA. Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. The Journal of Biological Chemistry. 281: 36793-802. PMID 17030510 DOI: 10.1074/Jbc.M608137200 |
0.64 |
|
| 2006 |
Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 317: 1188-99. PMID 16510697 DOI: 10.1124/Jpet.106.101949 |
0.635 |
|
| 2006 |
Sultan I, Senkal CE, Ponnusamy S, Bielawski J, Szulc Z, Bielawska A, Hannun YA, Ogretmen B. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. The Biochemical Journal. 393: 513-21. PMID 16201965 DOI: 10.1042/Bj20051083 |
0.651 |
|
| 2004 |
Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas Journal of Biological Chemistry. 279: 44311-44319. PMID 15317812 DOI: 10.1074/Jbc.M406920200 |
0.674 |
|
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