Mohammad A. Khanfar, Ph.D. - Publications

Affiliations: 
2010 University Of Louisiana at Monroe 
Area:
Pharmacy, Pharmaceutical Chemistry

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Khanfar MA, Alqtaishat S. Discovery of Potent Natural-Product-Derived SIRT2 Inhibitors Using Structure-Based Exploration of SIRT2 Pharmacophoric Space Coupled With QSAR Analyses. Anti-Cancer Agents in Medicinal Chemistry. PMID 33438557 DOI: 10.2174/1871520621666210112121523  1
2020 Hagenow J, Hagenow S, Grau K, Khanfar M, Hefke L, Proschak E, Stark H. Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs. Drug Design, Development and Therapy. 14: 371-393. PMID 32099324 DOI: 10.2147/Dddt.S236586  0.08
2019 Khanfar MA, Alqtaishat S. Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR analyses. Computational Biology and Chemistry. 79: 147-154. PMID 30818109 DOI: 10.1016/j.compbiolchem.2019.02.005  1
2018 El-Hawary SS, Sayed AM, Mohammed R, Khanfar MA, Rateb ME, Mohammed TA, Hajjar D, Hassan HM, Gulder TAM, Abdelmohsen UR. New Pim-1 Kinase Inhibitor From the Co-culture of Two Sponge-Associated Actinomycetes. Frontiers in Chemistry. 6: 538. PMID 30525020 DOI: 10.3389/Fchem.2018.00538  1
2018 Khanfar MA, Reiner D, Hagenow S, Stark H. Design, synthesis, and biological evaluation of novel oxadiazole- and thiazole-based histamine HR ligands. Bioorganic & Medicinal Chemistry. PMID 29960729 DOI: 10.1016/j.bmc.2018.06.028  0.01
2018 Bashatwah RM, Khanfar MA, Bardaweel SK. Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure-based exploration of PPK1Pharmacophoric space coupled with docking analyses. Journal of Molecular Recognition : Jmr. e2726. PMID 29740895 DOI: 10.1002/jmr.2726  1
2017 Khanfar MA, Taha MO. Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors. Journal of Molecular Recognition : Jmr. PMID 28299833 DOI: 10.1002/Jmr.2623  1
2016 Mera WA, Alzihlif M, Taha MO, Khanfar MA. Discovery of Potent Bruton's Tyrosine Kinase Inhibitors Using Ligand Based Modeling. Anti-Cancer Agents in Medicinal Chemistry. PMID 27671297 DOI: 10.2174/1871520616666160926114416  1
2016 Khanfar MA, Banat F, Alabed S, Alqtaishat S. Discovery of potent NEK2 inhibitors as potential anticancer agents using structure-based exploration of NEK2 pharmacophoric space coupled with QSAR analyses. Molecular Diversity. PMID 27599492 DOI: 10.1007/S11030-016-9696-5  1
2016 Khanfar MA, Affini A, Lutsenko K, Nikolic K, Butini S, Stark H. Multiple Targeting Approaches on Histamine H3 Receptor Antagonists. Frontiers in Neuroscience. 10: 201. PMID 27303254 DOI: 10.3389/Fnins.2016.00201  1
2016 Khanfar MA, Al-Qtaishat S, Habash M, Taha MO. Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling. Chemico-Biological Interactions. 254: 93-101. PMID 27216633 DOI: 10.1016/J.Cbi.2016.05.023  1
2016 Jarrar N, Alzweiri M, Al-Hiari Y, Farah S, Khanfar MA. Modified hummel-dreyer method and molecular modeling studies identified nicotinic acid analogues as carbonic anhydrase III ligands Letters in Drug Design and Discovery. 13: 401-410. DOI: 10.2174/1570180812666150821002900  1
2015 Khanfar MA, Bardaweel SK, Akl MR, El Sayed KA. Olive Oil-derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies. Phytotherapy Research : Ptr. 29: 1776-82. PMID 26248874 DOI: 10.1002/Ptr.5434  1
2015 Khanfar MA, Quinti L, Wang H, Nobles J, Kazantsev AG, Silverman RB. Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors. Acs Medicinal Chemistry Letters. 6: 607-11. PMID 26005542 DOI: 10.1021/Acsmedchemlett.5B00075  1
2015 Jaradat NJ, Khanfar MA, Habash M, Taha MO. Combining docking-based comparative intermolecular contacts analysis and k-nearest neighbor correlation for the discovery of new check point kinase 1 inhibitors. Journal of Computer-Aided Molecular Design. 29: 561-81. PMID 25956379 DOI: 10.1007/S10822-015-9848-1  1
2015 Al-Aboudi AM, Abu Zarga MH, Abu-Irmaileh BE, Awwadi FF, Khanfar MA. Three new seco-ursadiene triterpenoids from Salvia syriaca. Natural Product Research. 29: 102-8. PMID 25226348 DOI: 10.1080/14786419.2014.959518  1
2015 Mallow O, Khanfar MA, Malischewski M, Finke P, Hesse M, Lork E, Augenstein T, Breher F, Harmer JR, Vasilieva NV, Zibarev A, Bogomyakov AS, Seppelt K, Beckmann J. Diaryldichalcogenide radical cations Chemical Science. 6: 497-504. DOI: 10.1039/c4sc02964j  1
2015 Khanfar MA, Quinti L, Wang H, Nobles J, Kazantsev AG, Silverman RB. Design and evaluation of 3-(benzylthio)benzamide derivatives as potent and selective SIRT2 inhibitors Acs Medicinal Chemistry Letters. 6: 607-611. DOI: 10.1021/acsmedchemlett.5b00075  1
2015 Khanfar MA, Seppelt K. Fluorinated benzene cations Journal of Fluorine Chemistry. 179: 193-197. DOI: 10.1016/j.jfluchem.2015.08.004  1
2015 Taha MO, Khanfar MA. Oleuropein potently inhibits mammalian target of rapamycin: Possible involvement of tandem anomeric hyperconjugation-Michael reaction Medicinal Chemistry Research. 24: 616-623. DOI: 10.1007/S00044-014-1168-9  1
2014 Taha MO, Al-Sha'er MA, Khanfar MA, Al-Nadaf AH. Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis. European Journal of Medicinal Chemistry. 84: 454-65. PMID 25050878 DOI: 10.1016/J.Ejmech.2014.07.056  1
2014 Taha MO, Habash M, Khanfar MA. The use of docking-based comparative intermolecular contacts analysis to identify optimal docking conditions within glucokinase and to discover of new GK activators. Journal of Computer-Aided Molecular Design. 28: 509-47. PMID 24610240 DOI: 10.1007/S10822-014-9740-4  1
2014 Khanfar MA, Quinti L, Wang H, Choi SH, Kazantsev AG, Silverman RB. Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors European Journal of Medicinal Chemistry. 76: 414-426. PMID 24602787 DOI: 10.1016/J.Ejmech.2014.02.003  1
2014 Al-Sha'er MA, Khanfar MA, Taha MO. Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis. Journal of Molecular Modeling. 20: 2080. PMID 24469103 DOI: 10.1007/S00894-014-2080-4  1
2014 Abulateefeh SR, Khanfar MA, Al Bakain RZ, Taha MO. Synthesis and characterization of new derivatives of alginic acid and evaluation of their iron(III)-crosslinked beads as potential controlled release matrices. Pharmaceutical Development and Technology. 19: 856-67. PMID 24032476 DOI: 10.3109/10837450.2013.836222  1
2014 Khanfar M, Salem MS, Kaddour F. Preparation of sustained-release dosage form of Venlafaxine HCl using liquisolid technique Pharmaceutical Development and Technology. 19: 103-115. PMID 23347382 DOI: 10.3109/10837450.2012.757785  1
2014 Abu-Safieh KA, Khanfar MA, El-Barghouthi MI, Ali BF. Molecular structure and density functional theory calculations of 3-(3-nitrothien-2-yl)indole: Structural and vibrational analysis Journal of Chemical Crystallography. 44: 330-336. DOI: 10.1007/s10870-014-0519-1  1
2013 Khanfar MA, Taha MO. Elaborate ligand-based modeling coupled with multiple linear regression and k nearest neighbor QSAR analyses unveiled new nanomolar mTOR inhibitors. Journal of Chemical Information and Modeling. 53: 2587-612. PMID 24050502 DOI: 10.1021/Ci4003798  1
2013 Alzweiri M, Tarawneh R, Khanfar MA. Gas chromatography/trace analysis of derivatized azelaic acid as a stability marker. Journal of Separation Science. 36: 3200-5. PMID 23893928 DOI: 10.1002/Jssc.201300418  1
2013 Eterović VA, Del Valle-Rodriguez A, Pérez D, Carrasco M, Khanfar MA, El Sayed KA, Ferchmin PA. Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling. Bioorganic & Medicinal Chemistry. 21: 4678-86. PMID 23769165 DOI: 10.1016/J.Bmc.2013.05.018  1
2013 Khanfar MA, AbuKhader MM, Alqtaishat S, Taha MO. Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone. Journal of Molecular Graphics & Modelling. 42: 39-49. PMID 23545333 DOI: 10.1016/J.Jmgm.2013.02.009  1
2013 Al-Qawasmeh RA, Khanfar MA, Semreen MH, Odeh RA, Al-Tel TH. Design and synthesis of new hybrid triazine-indole derivatives as potential antimicrobial agents against hospital resistant strains Heterocycles. 87: 2385-2394. DOI: 10.3987/COM-13-12825  1
2013 Khanfar MA, El Sayed KA. The Veratrum alkaloids jervine, veratramine, and their analogues as prostate cancer migration and proliferation inhibitors: Biological evaluation and pharmacophore modeling Medicinal Chemistry Research. 22: 4775-4786. DOI: 10.1007/s00044-013-0495-6  1
2013 Molski MJ, Khanfar MA, Shorafa H, Seppelt K. Halogenated benzene cation radicals European Journal of Organic Chemistry. 3131-3136. DOI: 10.1002/ejoc.201201691  1
2012 Molski MJ, Mollenhauer D, Gohr S, Paulus B, Khanfar MA, Shorafa H, Strauss SH, Seppelt K. Halogenated benzene cation radicals. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 6644-54. PMID 22488870 DOI: 10.1002/chem.201102960  1
2012 Sayed KAE, Elnagar AY, Khanfar M. Abstract 4778: Computer-assisted molecular design use for the discovery and optimization of rationally-designed anticancer natural products. Discovery of olive oil-derived oleocanthal as a c-Met inhibitor and optimization of Veratrum alkaloids as Hedgehog signaling inhibitors Cancer Research. 72: 4778-4778. DOI: 10.1158/1538-7445.Am2012-4778  1
2012 Al-Qawasmeh RA, Khanfar MA, Zarga MHA, AlDamen MA. 2-(4-Methylphenyl)quinoline-4-carboxylic acid Acta Crystallographica Section E: Structure Reports Online. 68. DOI: 10.1107/S160053681203797  1
2011 Hassan HM, Elnagar AY, Khanfar MA, Sallam AA, Mohammed R, Shaala LA, Youssef DT, Hifnawy MS, El Sayed KA. Design of semisynthetic analogues and 3D-QSAR study of eunicellin-based diterpenoids as prostate cancer migration and invasion inhibitors. European Journal of Medicinal Chemistry. 46: 1122-30. PMID 21334794 DOI: 10.1016/J.Ejmech.2011.01.028  1
2011 Mudit M, Khanfar M, Shah GV, Sayed KA. Methods for evaluation of structural and biological properties of antiinvasive natural products. Methods in Molecular Biology (Clifton, N.J.). 716: 55-71. PMID 21318900 DOI: 10.1007/978-1-61779-012-6_4  1
2011 Baraka HN, Khanfar MA, Williams JC, El-Giar EM, El Sayed KA. Bioactive natural, biocatalytic, and semisynthetic tobacco cembranoids. Planta Medica. 77: 467-76. PMID 21049399 DOI: 10.1055/S-0030-1250478  1
2011 Al-Noaimi M, Crutchley RJ, AlDamen M, Rawashdeh AM, Khanfar MA, Seppelt K. Ruthenium(II) complexes with tetradentate pyridylthioazoimine [N,S,N,N] ligands: Synthesis, crystal structure and spectroscopy Polyhedron. 30: 2075-2082. DOI: 10.1016/J.Poly.2011.05.026  1
2010 Khanfar MA, Hill RA, Kaddoumi A, El Sayed KA. Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. Journal of Medicinal Chemistry. 53: 8534-45. PMID 21082766 DOI: 10.1021/Jm100941J  1
2010 Khanfar MA, El Sayed KA. Phenylmethylene hydantoins as prostate cancer invasion and migration inhibitors. CoMFA approach and QSAR analysis. European Journal of Medicinal Chemistry. 45: 5397-405. PMID 20869139 DOI: 10.1016/J.Ejmech.2010.08.066  1
2010 Abraham I, Jain S, Wu CP, Khanfar MA, Kuang Y, Dai CL, Shi Z, Chen X, Fu L, Ambudkar SV, El Sayed K, Chen ZS. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells. Biochemical Pharmacology. 80: 1497-506. PMID 20696137 DOI: 10.1016/J.Bcp.2010.08.001  1
2010 Khanfar MA, Youssef DT, El Sayed KA. 3D-QSAR studies of latrunculin-based actin polymerization inhibitors using CoMFA and CoMSIA approaches. European Journal of Medicinal Chemistry. 45: 3662-8. PMID 20684858 DOI: 10.1016/J.Ejmech.2010.05.012  1
2010 Hassan HM, Khanfar MA, Elnagar AY, Mohammed R, Shaala LA, Youssef DT, Hifnawy MS, El Sayed KA. Pachycladins A-E, prostate cancer invasion and migration inhibitory Eunicellin-based diterpenoids from the red sea soft coral Cladiella pachyclados. Journal of Natural Products. 73: 848-53. PMID 20420415 DOI: 10.1021/Np900787P  1
2010 Khanfar MA, Youssef DT, El Sayed KA. Semisynthetic latrunculin derivatives as inhibitors of metastatic breast cancer: biological evaluations, preliminary structure-activity relationship and molecular modeling studies. Chemmedchem. 5: 274-85. PMID 20043312 DOI: 10.1002/Cmdc.200900430  1
2010 Abdel Bar FM, Khanfar MA, Elnagar AY, Badria FA, Zaghloul AM, Ahmad KF, Sylvester PW, El Sayed KA. Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors. Bioorganic & Medicinal Chemistry. 18: 496-507. PMID 20034800 DOI: 10.1016/J.Bmc.2009.12.019  1
2010 Khanfar MA, Warad I, Aldamen MA. Trans-Dichlorido(2,2-dimethyl-propane-1,3-diamine)-bis-(triphenyl- phosphane)ruthenium(II) Acta Crystallographica Section E: Structure Reports Online. 66. DOI: 10.1107/S1600536810019276  1
2009 Bar FM, Khanfar MA, Elnagar AY, Liu H, Zaghloul AM, Badria FA, Sylvester PW, Ahmad KF, Raisch KP, El Sayed KA. Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors. Journal of Natural Products. 72: 1643-50. PMID 19691293 DOI: 10.1021/Np900312U  1
2009 Khanfar MA, Asal BA, Mudit M, Kaddoumi A, El Sayed KA. The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling. Bioorganic & Medicinal Chemistry. 17: 6032-9. PMID 19616957 DOI: 10.1016/J.Bmc.2009.06.054  1
2009 Shah GV, Muralidharan A, Thomas S, Gokulgandhi M, Mudit M, Khanfar M, El Sayed K. Identification of a small molecule class to enhance cell-cell adhesion and attenuate prostate tumor growth and metastasis. Molecular Cancer Therapeutics. 8: 509-20. PMID 19276166 DOI: 10.1158/1535-7163.Mct-08-0693  1
2009 Mudit M, Khanfar M, Muralidharan A, Thomas S, Shah GV, van Soest RW, El Sayed KA. Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products. Bioorganic & Medicinal Chemistry. 17: 1731-8. PMID 19195897 DOI: 10.1016/J.Bmc.2008.12.053  1
2009 Al-Qawasmeh RA, Zahra JA, Khanfar MA, Al-Hiari YM, El-Abadelah MM, Voelter W. A convenient synthesis of 1-alkyl-7-chloro-6-fluoro-3-nitro-4-quinolones Letters in Organic Chemistry. 6: 511-514. DOI: 10.2174/157017809789124812  1
2009 Al-Dweik MR, Zahra JA, Khanfar MA, El-Abadelah MM, Zeller KP, Voelter W. Heterocycles [h]-fused to 4-oxoquinoline-3-carboxylic acid. Part VII: Synthesis of some 6-oxoimidazo[4,5-h]quinoline-7-carboxylic acids and esters Monatshefte Fur Chemie. 140: 221-228. DOI: 10.1007/s00706-008-0056-8  1
2008 Sayed KA, Khanfar MA, Shallal HM, Muralidharan A, Awate B, Youssef DT, Liu Y, Zhou YD, Nagle DG, Shah G. Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells. Journal of Natural Products. 71: 396-402. PMID 18298079 DOI: 10.1021/Np070587W  1
2008 Abu-Safieh KA, Khanfar MA, Eichele K, Ali BF. 4-(4-Chloro-phen-yl)-1-(2-hydr-oxy-2,2-di-phenyl-acet-yl)thio-semicarbazide Acta Crystallographica Section E: Structure Reports Online. 64. DOI: 10.1107/S1600536808035964  1
2008 Khanfar MA, Abu Thaher BA, Zahra JA, Al-Qawasmeh RA, El-Abadelah MM, Voelter W. Metal-assisted oxidative cyclization of arylamidrazones II [1]. Novel synthesis of 1,4-diaryi[1,2,4]triazino[6,5-h]quinolines Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences. 63: 1107-1111.  1
2007 Khanfar MA, Abu-Safieh KA, Al-Far R, Ali BF, Maichle-Moessmer C. (E)-N′-[(Furan-2-yl)methyl-ene]-2-hydroxy-2,2-diphenyl-acetohydrazide monohydrate Acta Crystallographica Section E: Structure Reports Online. 63. DOI: 10.1107/S1600536807044443  1
2007 Zahra JA, Khanfar MA, El-Abadelah MM, Thaher BAA, El-Abadla NS, Voelter W. Synthesis of some ethyl 3-(aryldiazenyl)-7-oxo-dihydropyrido[2,3-f] quinoxaline-8-carboxylates Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences. 62: 1045-1051.  1
2006 Al-Hiari YM, Khanfar MA, Qaisi AM, Abu Shuheil MY, El-Abadelah MM, Boese R. Heterocycles [h]fused onto 4-oxoquinolines. Part I. synthesis of 6-oxo-6,9-dihydro[1,2,5]oxadiazolo[3,4-h-quinoline-7-carboxylic acid N-oxide Heterocycles. 68: 1163-1172. DOI: 10.3987/COM-06-10711  1
2003 Abu Zarga MH, Sabri SS, Hamed EM, Khanfar MA, Zeller KP, Rahman AU. A new eudesmane type sesquiterpene from Inula viscosa Natural Product Research. 17: 99-102. PMID 12713121 DOI: 10.1080/1478641031000103678  1
2003 Khanfar MA, Sabri SS, Abu Zarga MH, Zeller KP. The chemical constituents of Capparis spinosa of Jordanian origin Natural Product Research. 17: 9-14. PMID 12674136 DOI: 10.1080/10575630290034302  1
2002 El-Abadelah MM, Sabri SS, Khanfar MA, Yasin HA, Voelter W. Synthesis and properties of isoviagra [1]. A 2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7-one isomer of Viagra® Journal of Heterocyclic Chemistry. 39: 1055-1059.  1
2000 El-Abadelah MM, Sabri SS, Khanfar MA, Voelter W, Maichle-Mössmer C. X-ray crystal structure analysis of substituted 5-(2,3-dihydro-7-benzofuryl)-2-methylpyrazolo[4,3-d]pyrimidin-7-one (iso-biagra) [1] Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences. 55: 1079-1082.  1
2000 El-Abadelah MM, Sabri SS, Khanfar MA, Voelter W, Abdel-Jalil RJ, Maichle-Mössmer C, Al-Abed Y. Synthesis and properties of α-thiagra. A substituted 5-(2-thienyl)pyrazolo[4,3-d]pyrimidin-7-one bioisostere of viagra® Heterocycles. 53: 2643-2652.  1
1999 El-Abadelah MM, Sabri SS, Khanfar MA, Voelter W, Maichle-Mössmer C. X-ray structure analysis of iso-sildenafil (iso-viagra) Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences. 54: 1323-1326.  1
1999 Voelter W, El-Abadelah MM, Sabri SS, Khanfar MA. Synthesis and properties of Biagra [1]. A 5-(2,3-dihydro-7-benzofuryl) analog of Viagra® Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences. 54: 1469-1473.  1
1999 Voelter W, Maichle-Mössmer C, Khanfar MA, El-Abadelah MM, Sabri SS. X-Ray Structure Analysis of Substituted 5-(2,3-Dihydro-7-benzofuryl)-1-methylpyrazolo[4,3-d]pyrimidin-7-one (Biagra) [1] Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences. 54: 1602-1605.  1
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