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Hui-Hua Chang, Ph.D. - Publications

Affiliations: 
2013 Nutritional Sciences University of Arizona, Tucson, AZ 
Area:
Pharmacology, Oncology, Biochemistry
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Dong TS, Chang HH, Hauer M, Lagishetty V, Katzka W, Rozengurt E, Jacobs JP, Eibl G. Metformin Alters the Duodenal Microbiome and Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31545922 DOI: 10.1152/Ajpgi.00170.2019  0.311
2019 Chang HH, Eibl G. Obesity-Induced Adipose Tissue Inflammation as a Strong Promotional Factor for Pancreatic Ductal Adenocarcinoma. Cells. 8. PMID 31277269 DOI: 10.3390/Cells8070673  0.336
2019 Hao F, Xu Q, Wang J, Yu S, Chang HH, Sinnett-Smith J, Eibl G, Rozengurt E. Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. Plos One. 14: e0216603. PMID 31100067 DOI: 10.1371/Journal.Pone.0216603  0.42
2019 Hao F, Xu Q, Wang J, Yu S, Chang H, Sinnett-Smith J, Eibl G, Rozengurt E. Sa2010 – Lipophilic Statins Inhibit Yap Nuclear Localization, Coactivator Activity and Colony Formation in Pancreatic Cancer Cells and Prevent the Initial Stages of Pancreatic Ductal Adenocarcinoma in Kras Mice Gastroenterology. 156. DOI: 10.1016/S0016-5085(19)38033-3  0.424
2018 Xu M, Chang HH, Jung X, Moro A, Chou CEN, King J, Hines OJ, Sinnett-Smith J, Rozengurt E, Eibl G. Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice. Bmc Cancer. 18: 797. PMID 30086728 DOI: 10.1186/S12885-018-4713-Y  0.393
2018 Kaur K, Chang HH, Topchyan P, Cook JM, Barkhordarian A, Eibl G, Jewett A. Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice. Frontiers in Immunology. 9: 1229. PMID 29977235 DOI: 10.3389/Fimmu.2018.01229  0.353
2018 Chang HH, Moro A, Chou CEN, Dawson DW, French S, Schmidt AI, Sinnett-Smith J, Hao F, Hines OJ, Eibl G, Rozengurt E. Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. Scientific Reports. 8: 5899. PMID 29651002 DOI: 10.1038/S41598-018-24337-8  0.349
2018 Takakura K, Speakman S, Chang H, Gretler S, Mareninova OA, Dawson DW, Eibl G, Torisu Y, Saruta M, Grippo P, Gukovskaya A. Tu1343 - TP53 Determines the Effects of Beclin1 Haploinsufficiency on Autophagy and Tumorigenesis in a Kras G12D Mouse Model of Pancreatic Cancer Gastroenterology. 154: S-937. DOI: 10.1016/S0016-5085(18)33159-7  0.381
2018 Chang H, Sinnett-Smith J, Schmidt AI, Hines OJ, Eibl G, Rozengurt E. Mo1988 - Metformin Prevents Kras-Mutant Pancreatic Ductal Adenocarcinoma Promoted by Diet-Induced Obesity Gastroenterology. 154: S-873. DOI: 10.1016/S0016-5085(18)32951-2  0.306
2018 Chang H, Sinnett-Smith J, Hines OJ, Rozengurt E, Eibl G. Metformin prevents obesity-promoted pancreatic cancer development in the conditional KrasG12D mouse model Pancreatology. 18: S153. DOI: 10.1016/J.Pan.2018.05.411  0.372
2017 Kaur K, Chang HH, Cook J, Eibl G, Jewett A. Suppression of Gingival NK Cells in Precancerous and Cancerous Stages of Pancreatic Cancer in KC and BLT-Humanized Mice. Frontiers in Immunology. 8: 1606. PMID 29255459 DOI: 10.3389/Fimmu.2017.01606  0.379
2017 Chang HH, Moro A, Takakura K, Su HY, Mo A, Nakanishi M, Waldron RT, French SW, Dawson DW, Hines OJ, Li G, Go VLW, Sinnett-Smith J, Pandol SJ, Lugea A, et al. Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice. Plos One. 12: e0184455. PMID 28886117 DOI: 10.1371/Journal.Pone.0184455  0.38
2017 Schmidt A, Sinnett-Smith J, Young S, Chang HH, Hines OJ, Dawson DW, Rozengurt E, Eibl G. Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism. Surgery. PMID 28222855 DOI: 10.1016/J.Surg.2016.12.037  0.394
2017 Hao F, Chang J, Sinnett-Smith J, Eibl G, Chang H, Rozengurt E. Statins Potently Inhibit YAP Activity and Proliferation of Mouse Pancreatic Cells Isolated From KC and KPC Mice Gastroenterology. 152: S837. DOI: 10.1016/S0016-5085(17)32891-3  0.388
2016 Yang J, Waldron RT, Su HY, Moro A, Chang HH, Eibl G, Ferreri K, Kandeel FR, Lugea A, Li L, Pandol SJ. Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00251.2016. PMID 27609771 DOI: 10.1152/Ajpgi.00251.2016  0.314
2016 Xu M, Jung X, Chang H, Moro A, Stark A, Schmidt AI, Eibl G, Hines OJ. 416 Visceral Pre-Adipocytes From Obese KrasGRD Mice Stimulate Proliferation of Pancreatic Intraepithelial Neoplasms Gastroenterology. 150. DOI: 10.1016/S0016-5085(16)33982-8  0.311
2015 Hertzer KM, Xu M, Moro A, Dawson DW, Du L, Li G, Chang HH, Stark AP, Jung X, Hines OJ, Eibl G. Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer. Pancreas. PMID 26495779 DOI: 10.1097/Mpa.0000000000000497  0.368
2015 Chang HH, Young SH, Sinnett-Smith J, Chou CE, Moro A, Hertzer KM, Hines OJ, Rozengurt E, Eibl G. Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1. American Journal of Physiology. Cell Physiology. ajpcell.00417.2014. PMID 26310818 DOI: 10.1152/Ajpcell.00417.2014  0.441
2015 Stark AP, Chang HH, Jung X, Moro A, Hertzer K, Xu M, Schmidt A, Hines OJ, Eibl G. E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice. Surgery. PMID 26297056 DOI: 10.1016/J.Surg.2015.07.023  0.349
2015 Chang H, Young S, Sinnett-Smith J, Chou CEN, Hines OJ, Rozengurt E, Eibl G. Abstract 1028: Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA and EP1/calcium-mediated mechanisms in human pancreatic carcinoma cells Cancer Research. 75: 1028-1028. DOI: 10.1158/1538-7445.Am2015-1028  0.311
2014 Chang H, Eibl G. Abstract 5291: Signaling cross-talks in obesity-associated pancreatic cancer: Interaction between prostaglandin E2 signaling and mTOR pathway Cancer Research. 74: 5291-5291. DOI: 10.1158/1538-7445.Am2014-5291  0.429
2013 Norberg JK, Sells E, Chang HH, Alla SR, Zhang S, Meuillet EJ. Targeting inflammation: multiple innovative ways to reduce prostaglandin E₂. Pharmaceutical Patent Analyst. 2: 265-88. PMID 24237030 DOI: 10.4155/Ppa.12.90  0.594
2013 Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prevention Research (Philadelphia, Pa.). 6: 1064-73. PMID 23943783 DOI: 10.1158/1940-6207.Capr-13-0065  0.386
2013 Medda F, Sells E, Chang HH, Dietrich J, Chappeta S, Smith B, Gokhale V, Meuillet EJ, Hulme C. Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells. Bioorganic & Medicinal Chemistry Letters. 23: 528-31. PMID 23237838 DOI: 10.1016/J.Bmcl.2012.11.030  0.646
2012 Smith B, Chang HH, Medda F, Gokhale V, Dietrich J, Davis A, Meuillet EJ, Hulme C. Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells. Bioorganic & Medicinal Chemistry Letters. 22: 3567-70. PMID 22516282 DOI: 10.1016/J.Bmcl.2012.03.013  0.652
2012 Chang HH, Song Z, Wisner L, Tripp T, Gokhale V, Meuillet EJ. Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers. Investigational New Drugs. 30: 1865-77. PMID 21931968 DOI: 10.1007/S10637-011-9748-8  0.689
2012 Sells E, Medda F, Chang H, Gokhale V, Hulme C, Meuillet EJ. Abstract 2834: Discovery of a novel class of prostaglandin e2 synthesis inhibitors with anti-tumor activity in colorectal cancer Cancer Research. 72: 2834-2834. DOI: 10.1158/1538-7445.Am2012-2834  0.695
2011 Chang HH, Meuillet EJ. Identification and development of mPGES-1 inhibitors: where we are at? Future Medicinal Chemistry. 3: 1909-34. PMID 22023034 DOI: 10.4155/Fmc.11.136  0.625
2010 Chang H, Song Z, Tripp T, Wisner L, Gokhale V, Hulme C, Meuillet EJ. Abstract 3565: Novel inhibitors of mPGES-1 exhibit anti-tumor activity in colorectal and lung cancers Cancer Research. 70: 3565-3565. DOI: 10.1158/1538-7445.Am10-3565  0.683
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