Michelle R. Arkin - Publications

Affiliations: 
University of California, San Francisco, San Francisco, CA 
Area:
Electron transfer in DNA, protein-protein interactions, protein engineering, chemical biology, drug discovery

101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chen S, Suzuki BM, Dohrmann J, Singh R, Arkin MR, Caffrey CR. A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery. Communications Biology. 3: 747. PMID 33349640 DOI: 10.1038/s42003-020-01402-5  0.6
2020 Pohan G, Espinosa JA, Chen S, Ang KK, Arkin MR, Markossian S. Multiparametric High-Content Assays to Measure Cell Health and Oxidative Damage as a Model for Drug-Induced Liver Injury. Current Protocols in Chemical Biology. 12: e90. PMID 33315311 DOI: 10.1002/cpch.90  0.6
2020 Abdel Aziz MH, Fan Y, Liu L, Moasser M, Fu H, Jura N, Arkin MR. Expression and Purification of Active Human Kinases Using Pichia pastoris as A General-Purpose Host. Protein Expression and Purification. 105780. PMID 33115654 DOI: 10.1016/j.pep.2020.105780  0.48
2020 Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, ... ... Arkin MR, et al. Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nature Immunology. PMID 32661365 DOI: 10.1038/s41590-020-0754-x  0.32
2020 Leandro J, Khamrui S, Wang H, Suebsuwong C, Nemeria NS, Huynh K, Moustakim M, Secor C, Wang M, Dodatko T, Stauffer B, Wilson CG, Yu C, Arkin MR, Jordan F, et al. Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex. Acs Chemical Biology. PMID 32633484 DOI: 10.1021/acschembio.0c00114  0.64
2020 Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, ... ... Arkin MR, et al. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nature Immunology. PMID 32284594 DOI: 10.1038/s41590-020-0654-0  0.32
2020 Chen X, Li Y, Wang C, Tang Y, Mok SA, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL, Gestwicki JE, Arkin M, Cuervo AM, Gan L. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. Molecular Neurodegeneration. 15: 2. PMID 31906970 DOI: 10.1186/s13024-019-0354-0  0.96
2019 Zhang P, Zhai Y, Cregg J, Ang KK, Arkin M, Kenyon C. Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Lifespan. G3 (Bethesda, Md.). PMID 31879284 DOI: 10.1534/g3.119.400618  0.32
2019 Sanchez MI, de Vries LE, Lehmann C, Lee JT, Ang KK, Wilson C, Chen S, Arkin MR, Bogyo M, Deu E. Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening. Plos One. 14: e0226270. PMID 31851699 DOI: 10.1371/journal.pone.0226270  0.6
2019 Walhart T, Isaacson-Wechsler E, Ang KH, Arkin M, Tugizov S, Palefsky JM. A Cell-Based Luminescence Reporter Plasmid Assay for High-Throughput Screening to Identify Novel FDA-Approved Drug Inhibitors of HPV-16 Infection. Slas Discovery : Advancing Life Sciences R & D. 2472555219860771. PMID 31361520 DOI: 10.1177/2472555219860771  0.4
2019 Sijbesma E, Hallenbeck KK, Leysen S, de Vink P, Skora L, Jahnke W, Brunsveld L, Arkin MR, Ottmann C. Site-Directed Fragment-based Screening for the Discovery of Protein-Protein Interaction Stabilizers. Journal of the American Chemical Society. PMID 30707565 DOI: 10.1021/jacs.8b11658  0.4
2019 Klein HL, Ang KKH, Arkin MR, Beckwitt EC, Chang YH, Fan J, Kwon Y, Morten MJ, Mukherjee S, Pambos OJ, El Sayyed H, Thrall ES, Vieira-da-Rocha JP, Wang Q, Wang S, et al. Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes. Microbial Cell (Graz, Austria). 6: 65-101. PMID 30652106 DOI: 10.15698/mic2019.01.665  0.6
2018 LaPorte MG, Burnett JC, Colombo R, Bulfer SL, Alverez C, Chou TF, Neitz RJ, Green N, Moore WJ, Yue Z, Li S, Arkin MR, Wipf P, Huryn DM. Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97. Acs Medicinal Chemistry Letters. 9: 1075-1081. PMID 30429948 DOI: 10.1021/acsmedchemlett.8b00372  0.36
2018 Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, ... ... Arkin MR, et al. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nature Immunology. PMID 30323343 DOI: 10.1038/s41590-018-0232-x  0.4
2018 Lee J, Pappalardo Z, Chopra DG, Hennings TG, Vaughn I, Lan C, Choe JJ, Ang K, Chen S, Arkin M, McManus MT, German MS, Ku GM. A genetic interaction map of insulin production identifies Mfi as an inhibitor of mitochondrial fission. Endocrinology. PMID 30059978 DOI: 10.1210/en.2018-00426  0.6
2018 El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P. Octopamine-signaling in the metazoan pathogen, : localization, small-molecule screening and opportunities for drug development. Disease Models & Mechanisms. PMID 29925529 DOI: 10.1242/dmm.033563  0.6
2018 Markossian S, Ang KK, Wilson CG, Arkin MR. Small-Molecule Screening for Genetic Diseases. Annual Review of Genomics and Human Genetics. PMID 29799800 DOI: 10.1146/annurev-genom-083117-021452  0.64
2017 Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, ... ... Arkin MR, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. PMID 29045385 DOI: 10.1038/nature24006  0.96
2017 Hallenbeck KK, Davies JL, Merron C, Ogden P, Sijbesma E, Ottmann C, Renslo AR, Wilson C, Arkin MR. A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments. Slas Discovery. 2472555217732072. PMID 28945980 DOI: 10.1177/2472555217732072  0.6
2017 Carlson HK, Mullan MR, Mosqueda LA, Chen S, Arkin MR, Coates JD. High-throughput screening to identify potent and specific inhibitors of microbial sulfate reduction. Environmental Science & Technology. PMID 28492331 DOI: 10.1021/acs.est.7b00686  0.6
2017 Burnett JC, Lim C, Peyser BD, Samankumara LP, Kovaliov M, Colombo R, Bulfer SL, LaPorte MG, Hermone AR, McGrath CF, Arkin MR, Gussio R, Huryn DM, Wipf P. A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site. Organic & Biomolecular Chemistry. PMID 28352916 DOI: 10.1039/c7ob00526a  0.36
2017 Pappalardo Z, Chopra DG, Hennings TG, Richards H, Choe J, Yang K, Baeyens L, Ang K, Chen S, Arkin M, German MS, McManus MT, Ku GM. A Whole Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. Diabetes. PMID 28246293 DOI: 10.2337/db16-0962  0.6
2016 Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J. Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. Journal of Biomolecular Screening. PMID 27932698 DOI: 10.1177/1087057116681407  0.64
2016 Liu H, Chen S, Huang K, Kim J, Mo H, Iovine R, Gendre J, Pascal P, Li Q, Sun Y, Dong Z, Arkin M, Guo S, Huang B. A High-Content Larval Zebrafish Brain Imaging Method for Small Molecule Drug Discovery. Plos One. 11: e0164645. PMID 27732643 DOI: 10.1371/journal.pone.0164645  0.96
2016 Hallenbeck KK, Turner DM, Renslo AR, Arkin MR. Covalent Strategies in Structure-Guided Drug Discovery. Current Topics in Medicinal Chemistry. PMID 27449257 DOI: 10.2174/1568026616666160719163839  0.6
2016 Hallenbeck KK, Turner DM, Renslo AR, Arkin MR. Covalent Strategies in Structure-Guided Drug Discovery. Current Topics in Medicinal Chemistry. PMID 27448650  0.6
2016 Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. Elife. 5. PMID 27435960 DOI: 10.7554/eLife.11878  0.96
2016 Bulfer SL, Chou TF, Arkin MR. p97 disease mutations modulate nucleotide-induced con-formation to alter protein-protein interactions. Acs Chemical Biology. PMID 27267671 DOI: 10.1021/acschembio.6b00350  0.96
2016 Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, ... Arkin MR, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. Acs Medicinal Chemistry Letters. 7: 182-7. PMID 26985295 DOI: 10.1021/acsmedchemlett.5b00396  0.36
2016 Visscher M, Arkin MR, Dansen TB. Covalent targeting of acquired cysteines in cancer. Current Opinion in Chemical Biology. 30: 61-7. PMID 26629855 DOI: 10.1016/j.cbpa.2015.11.004  0.96
2016 Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, ... Arkin MR, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway Acs Medicinal Chemistry Letters. 7: 182-187. DOI: 10.1021/acsmedchemlett.5b00396  0.96
2015 Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, LaPorte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. Acs Medicinal Chemistry Letters. 6: 1225-30. PMID 26713109 DOI: 10.1021/acsmedchemlett.5b00364  0.36
2015 Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. A gene-expression screen identifies a non-toxic sumoylation inhibitor that Mimics SUMO-less human LRH-1 in liver. Elife. 4. PMID 26653140 DOI: 10.7554/eLife.09003  0.96
2015 Frye SV, Arkin MR, Arrowsmith CH, Conn PJ, Glicksman MA, Hull-Ryde EA, Slusher BS. Tackling reproducibility in academic preclinical drug discovery. Nature Reviews. Drug Discovery. 14: 733-4. PMID 26388229 DOI: 10.1038/nrd4737  0.96
2015 Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, et al. Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease. Plos Pathogens. 11: e1005058. PMID 26186534 DOI: 10.1371/journal.ppat.1005058  0.48
2015 Neitz RJ, Bryant C, Chen S, Gut J, Hugo Caselli E, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR. Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. Bioorganic & Medicinal Chemistry Letters. 25: 4834-7. PMID 26144347 DOI: 10.1016/j.bmcl.2015.06.066  0.96
2015 Ekins S, Lage de Siqueira-Neto J, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. Plos Neglected Tropical Diseases. 9: e0003878. PMID 26114876 DOI: 10.1371/journal.pntd.0003878  0.96
2015 Pfaff SJ, Chimenti MS, Kelly MJ, Arkin MR. Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 1278: 587-613. PMID 25859978 DOI: 10.1007/978-1-4939-2425-7_39  0.96
2015 Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, et al. Altered cofactor regulation with disease-associated p97/VCP mutations. Proceedings of the National Academy of Sciences of the United States of America. 112: E1705-14. PMID 25775548 DOI: 10.1073/pnas.1418820112  0.96
2015 Tran K, Arkin MR, Beal PA. Tethering in RNA: an RNA-binding fragment discovery tool. Molecules (Basel, Switzerland). 20: 4148-61. PMID 25749683 DOI: 10.3390/molecules20034148  0.96
2015 Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, ... ... Arkin M, et al. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. Plos Neglected Tropical Diseases. 9: e0003534. PMID 25700363 DOI: 10.1371/journal.pntd.0003534  0.96
2015 Chimenti MS, Bulfer SL, Neitz RJ, Renslo AR, Jacobson MP, James TL, Arkin MR, Kelly MJ. A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP. Journal of Biomolecular Screening. 20: 788-800. PMID 25690569 DOI: 10.1177/1087057115570550  0.96
2015 Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J. Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. The Biochemical Journal. 465: 149-61. PMID 25287889 DOI: 10.1042/BJ20140793  0.96
2015 Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, ... Arkin M, et al. Lead identification to clinical candidate selection: drugs for Chagas disease. Journal of Biomolecular Screening. 20: 101-11. PMID 25281737 DOI: 10.1177/1087057114553103  0.6
2015 Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, Laporte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97 Acs Medicinal Chemistry Letters. 6: 1225-1230. DOI: 10.1021/acsmedchemlett.5b00364  0.96
2014 Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proceedings of the National Academy of Sciences of the United States of America. 111: 18590-5. PMID 25518860 DOI: 10.1073/pnas.1415365112  0.96
2014 Arkin MR, Tang Y, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chemistry & Biology. 21: 1102-14. PMID 25237857 DOI: 10.1016/j.chembiol.2014.09.001  0.96
2014 Dar RD, Hosmane NN, Arkin MR, Siliciano RF, Weinberger LS. Screening for noise in gene expression identifies drug synergies. Science (New York, N.Y.). 344: 1392-6. PMID 24903562 DOI: 10.1126/science.1250220  0.96
2014 Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. Journal of Molecular Biology. 426: 2886-99. PMID 24878061 DOI: 10.1016/j.jmb.2014.05.022  0.96
2014 Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area. Combinatorial Chemistry & High Throughput Screening. 17: 333-42. PMID 24661212 DOI: 10.2174/1386207317666140323133841  0.96
2014 Flygare JA, Arkin MR. Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases. Current Topics in Medicinal Chemistry. 14: 319-25. PMID 24283214 DOI: 10.2174/1568026613666131126224039  0.96
2014 Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, ... Arkin MR, et al. Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem. 9: 73-7, 2. PMID 24259468 DOI: 10.1002/cmdc.201300424  0.96
2013 Wilson CG, Arkin MR. Probing structural adaptivity at PPI interfaces with small molecules. Drug Discovery Today. Technologies. 10: e501-8. PMID 24451641 DOI: 10.1016/j.ddtec.2012.10.009  0.96
2013 Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife. 2: e00508. PMID 24040509 DOI: 10.7554/eLife.00508  0.96
2013 Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2: e00498. PMID 23741617 DOI: 10.7554/eLife.00498  0.96
2013 Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. Acs Chemical Biology. 8: 1841-51. PMID 23738709 DOI: 10.1021/cb400289x  0.96
2013 Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, et al. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein Journal of Organic Chemistry. 9: 15-25. PMID 23400640 DOI: 10.3762/bjoc.9.3  0.96
2012 Zhong M, Gadek TR, Bui M, Shen W, Burnier J, Barr KJ, Hanan EJ, Oslob JD, Yu CH, Zhu J, Arkin MR, Evanchik MJ, Flanagan WM, Hoch U, Hyde J, et al. Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. Acs Medicinal Chemistry Letters. 3: 203-6. PMID 24900456 DOI: 10.1021/ml2002482  0.96
2012 Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, ... ... Arkin MR, et al. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One. 7: e50864. PMID 23227217 DOI: 10.1371/journal.pone.0050864  0.96
2012 Wu VM, Chen SC, Arkin MR, Reiter JF. Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 13644-9. PMID 22864913 DOI: 10.1073/pnas.1207170109  0.96
2012 Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. Plos Neglected Tropical Diseases. 6: e1736. PMID 22860142 DOI: 10.1371/journal.pntd.0001736  0.96
2012 Pu M, Hayashi T, Cottam H, Mulvaney J, Arkin M, Corr M, Carson D, Messer K. Analysis of high-throughput screening assays using cluster enrichment. Statistics in Medicine. 31: 4175-89. PMID 22763983 DOI: 10.1002/sim.5455  0.96
2012 Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, et al. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nature Medicine. 18: 956-60. PMID 22610278 DOI: 10.1038/nm.2758  0.96
2012 Lee H, Moody-Davis A, Saha U, Suzuki BM, Asarnow D, Chen S, Arkin M, Caffrey CR, Singh R. Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis. Bmc Genomics. 13: S4. PMID 22369037 DOI: 10.1186/1471-2164-13-S1-S4  0.96
2011 Tang Y, Wells JA, Arkin MR. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. The Journal of Biological Chemistry. 286: 34147-54. PMID 21828056 DOI: 10.1074/jbc.M111.247627  0.96
2011 De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. Plos Neglected Tropical Diseases. 5: e1253. PMID 21811648 DOI: 10.1371/journal.pntd.0001253  0.96
2011 Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Mining a cathepsin inhibitor library for new antiparasitic drug leads. Plos Neglected Tropical Diseases. 5: e1023. PMID 21572521 DOI: 10.1371/journal.pntd.0001023  0.96
2011 Ben Khalaf N, De Muylder G, Ratnam J, Kean-Hooi Ang K, Arkin M, McKerrow J, Chenik M. A high-throughput turbidometric assay for screening inhibitors of Leishmania major protein disulfide isomerase. Journal of Biomolecular Screening. 16: 545-51. PMID 21441416 DOI: 10.1177/1087057111401026  0.96
2011 Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. An image-based assay for high throughput screening of Giardia lamblia. Journal of Microbiological Methods. 84: 398-405. PMID 21262276 DOI: 10.1016/j.mimet.2010.12.026  0.96
2011 Zhong M, Hanan EJ, Shen W, Bui M, Arkin MR, Barr KJ, Evanchik MJ, Hoch U, Hyde J, Martell JR, Oslob JD, Paulvannan K, Prabhu S, Silverman JA, Wright J, et al. Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. Bioorganic & Medicinal Chemistry Letters. 21: 307-10. PMID 21109434 DOI: 10.1016/j.bmcl.2010.11.014  0.96
2011 Wilson CG, Arkin MR. Small-molecule inhibitors of IL-2/IL-2R: lessons learned and applied. Current Topics in Microbiology and Immunology. 348: 25-59. PMID 20703966 DOI: 10.1007/82_2010_93  0.96
2010 Zhong M, Shen W, Barr KJ, Arbitrario JP, Arkin MR, Bui M, Chen T, Cunningham BC, Evanchik MJ, Hanan EJ, Hoch U, Huen K, Hyde J, Kumer JL, Lac T, et al. Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 5269-73. PMID 20655213 DOI: 10.1016/j.bmcl.2010.06.145  0.96
2010 Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS. Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrobial Agents and Chemotherapy. 54: 3326-34. PMID 20547819 DOI: 10.1128/AAC.01777-09  0.96
2010 Hawtin RE, Stockett DE, Byl JA, McDowell RS, Nguyen T, Arkin MR, Conroy A, Yang W, Osheroff N, Fox JA. Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. Plos One. 5: e10186. PMID 20419121 DOI: 10.1371/journal.pone.0010186  0.96
2010 Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, et al. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. Journal of Medicinal Chemistry. 53: 52-60. PMID 19908842 DOI: 10.1021/jm901069a  0.96
2009 Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 19: 6218-21. PMID 19773167 DOI: 10.1016/j.bmcl.2009.08.098  0.96
2009 Mckerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. Two approaches to discovering and developing new drugs for Chagas disease Memorias Do Instituto Oswaldo Cruz. 104: 263-269. PMID 19753483 DOI: 10.1590/S0074-02762009000900034  0.96
2009 Arkin MR, Whitty A. The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions. Current Opinion in Chemical Biology. 13: 284-90. PMID 19553156 DOI: 10.1016/j.cbpa.2009.05.125  0.96
2009 Conroy A, Stockett DE, Walker D, Arkin MR, Hoch U, Fox JA, Hawtin RE. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemotherapy and Pharmacology. 64: 723-32. PMID 19169685 DOI: 10.1007/s00280-008-0921-5  0.96
2009 Rubio BK, Tenney K, Ang KH, Abdulla M, Arkin M, McKerrow JH, Crews P. The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness Journal of Natural Products. 72: 218-222. PMID 19159277 DOI: 10.1021/np800711a  0.96
2008 Choong IC, Serafimova I, Fan J, Stockett D, Chan E, Cheeti S, Lu Y, Fahr B, Pham P, Arkin MR, Walker DH, Hoch U. A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties. Bioorganic & Medicinal Chemistry Letters. 18: 5763-5. PMID 18842409 DOI: 10.1016/j.bmcl.2008.09.073  0.96
2005 Waal ND, Yang W, Oslob JD, Arkin MR, Hyde J, Lu W, McDowell RS, Yu CH, Raimundo BC. Identification of nonpeptidic small-molecule inhibitors of interleukin-2. Bioorganic & Medicinal Chemistry Letters. 15: 983-7. PMID 15686897 DOI: 10.1016/j.bmcl.2004.12.045  0.96
2004 Raimundo BC, Oslob JD, Braisted AC, Hyde J, McDowell RS, Randal M, Waal ND, Wilkinson J, Yu CH, Arkin MR. Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. Journal of Medicinal Chemistry. 47: 3111-30. PMID 15163192 DOI: 10.1021/jm049967u  0.96
2004 Arkin MR, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nature Reviews. Drug Discovery. 3: 301-17. PMID 15060526 DOI: 10.1038/nrd1343  0.96
2003 Hyde J, Braisted AC, Randal M, Arkin MR. Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2. Biochemistry. 42: 6475-83. PMID 12767230 DOI: 10.1021/bi034138g  0.96
2003 Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M. Drug discovery at signaling interfaces. Ernst Schering Research Foundation Workshop. 19-27. PMID 12664533 DOI: 10.1007/978-3-662-05314-0_3  0.96
2003 Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC. Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. Journal of the American Chemical Society. 125: 3714-5. PMID 12656598 DOI: 10.1021/ja034247i  0.96
2003 Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. Binding of small molecules to an adaptive protein-protein interface. Proceedings of the National Academy of Sciences of the United States of America. 100: 1603-8. PMID 12582206 DOI: 10.1073/pnas.252756299  0.96
2001 Arkin M, Lear JD. A new data analysis method to determine binding constants of small molecules to proteins using equilibrium analytical ultracentrifugation with absorption optics Analytical Biochemistry. 299: 98-107. PMID 11726190 DOI: 10.1006/abio.2001.5396  0.96
1998 Arkin MR, Wells JA. Probing the importance of second sphere residues in an esterolytic antibody by phage display Journal of Molecular Biology. 284: 1083-1094. PMID 9837728 DOI: 10.1006/jmbi.1998.2234  0.96
1997 Arkin MR, Stemp ED, Pulver SC, Barton JK. Long-range oxidation of guanine by Ru(III) in duplex DNA. Chemistry & Biology. 4: 389-400. PMID 9195873  0.88
1997 Olson EJC, Hu D, Hörmann A, Jonkman AM, Arkin MR, Stemp EDA, Barton JK, Barbara PF. First observation of the key intermediate in the 'light-switch' mechanism of [Ru(phen)2dppz]2+ Journal of the American Chemical Society. 119: 11458-11467. DOI: 10.1021/ja971151d  0.88
1997 Stemp EDA, Arkin MR, Barton JK. Oxidation of guanine in DNA by Ru(phen)2(dppz)3+ using the flash-quench technique Journal of the American Chemical Society. 119: 2921-2925. DOI: 10.1021/ja963606p  0.88
1996 Arkin MR, Stemp ED, Holmlin RE, Barton JK, Hörmann A, Olson EJ, Barbara PF. Rates of DNA-mediated electron transfer between metallointercalators. Science (New York, N.Y.). 273: 475-80. PMID 8662532  0.88
1996 Arkin MR, Stemp EDA, Turro C, Turro NJ, Barton JK. Luminescence quenching in supramolecular systems: A comparison of DNA- and SDS micelle-mediated photoinduced electron transfer between metal complexes Journal of the American Chemical Society. 118: 2267-2274. DOI: 10.1021/ja9532998  0.88
1996 Hörmann A, Olson EJC, Barbara PF, Arkin MR, Stemp EDA, Holmlin RE, Barton JK. Time resolved electron transfer studies between metallointercalators in DNA Springer Series in Chemical Physics. 62: 359-360.  0.88
1995 Burgmayer SJN, Arkin MR, Bostick L, Dempster S, Everett KM, Layton HL, Paul KE, Rogge C, Rheingold AL. Tetrahydropterin reactions of dioxo-molybdenum(6+) complexes: Does redox occur? Journal of the American Chemical Society. 117: 5812-5823.  0.88
1995 Stemp EDA, Arkin MR, Barton JK. Electron transfer between metallointercalators bound to DNA: Spectral identification of the transient intermediate Journal of the American Chemical Society. 117: 2375-2376.  0.88
1994 Murphy CJ, Arkin MR, Ghatlia ND, Bossmann S, Turro NJ, Barton JK. Fast photoinduced electron transfer through DNA intercalation. Proceedings of the National Academy of Sciences of the United States of America. 91: 5315-9. PMID 8202486 DOI: 10.1073/pnas.91.12.5315  0.88
1993 Murphy CJ, Arkin MR, Jenkins Y, Ghatlia ND, Bossmann SH, Turro NJ, Barton JK. Long-range photoinduced electron transfer through a DNA helix. Science (New York, N.Y.). 262: 1025-9. PMID 7802858 DOI: 10.1126/science.7802858  0.88
1993 Arkin M, Murphy C, Jenkins Y, Turro N, Barton J. Evidence for photoelectron transfer through DNA intercalation Journal of Inorganic Biochemistry. 51: 526. DOI: 10.1016/0162-0134(93)85552-J  0.56
Show low-probability matches.