Steven E. Shoelson, MD, PhD - Publications

Joslin Diabetes Center  Harvard University, Cambridge, MA, United States 
insulin resistance and type 2 diabetes. Structural biology of diabetes and insulin resistance.

181 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Lee BC, Kim MS, Pae M, Yamamoto Y, Eberlé D, Shimada T, Kamei N, Park HS, Sasorith S, Woo JR, You J, Mosher W, Brady HJ, Shoelson SE, Lee J. Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity. Cell Metabolism. PMID 27050305 DOI: 10.1016/J.Cmet.2016.03.002  0.64
2015 Rubin MR, Goldfine AB, McMahon DJ, Donovan DS, Cremers S, Dworakowski E, Schaefer EJ, Shoelson SE, Silverberg SJ. Effects of the anti-inflammatory drug salsalate on bone turnover in type 2 diabetes mellitus. Endocrine. PMID 25636441 DOI: 10.1007/S12020-015-0535-8  0.64
2014 Pearce LR, Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, et al. Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1. Endocrinology. 155: 3219-26. PMID 24971614 DOI: 10.1210/En.2014-1264  0.64
2014 Okazaki T, Liang F, Li T, Lemaire C, Danialou G, Shoelson SE, Petrof BJ. Muscle-specific inhibition of the classical nuclear factor-κB pathway is protective against diaphragmatic weakness in murine endotoxemia. Critical Care Medicine. 42: e501-9. PMID 24933061 DOI: 10.1097/Ccm.0000000000000407  0.64
2014 Lee J, Miyazaki M, Romeo GR, Shoelson SE. Insulin receptor activation with transmembrane domain ligands. The Journal of Biological Chemistry. 289: 19769-77. PMID 24867955 DOI: 10.1074/Jbc.M114.578641  0.64
2014 Goldfine AB, Jablonski KA, Shoelson SE, Creager MA. Response to comment on Goldfine et al. Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD). Diabetes care 2013;36:4132-4139. Diabetes Care. 37: e112. PMID 24757239 DOI: 10.2337/Dc14-0222  0.64
2014 Barzilay JI, Jablonski KA, Fonseca V, Shoelson SE, Goldfine AB, Strauch C, Monnier VM. The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes. Diabetes Care. 37: 1083-91. PMID 24255104 DOI: 10.2337/Dc13-1527  0.64
2013 Kim MS, Yamamoto Y, Kim K, Kamei N, Shimada T, Liu L, Moore K, Woo JR, Shoelson SE, Lee J. Regulation of diet-induced adipose tissue and systemic inflammation by salicylates and pioglitazone. Plos One. 8: e82847. PMID 24376593 DOI: 10.1371/Journal.Pone.0082847  0.64
2013 King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC. Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes. Plos One. 8: e77452. PMID 24204831 DOI: 10.1371/Journal.Pone.0077452  0.64
2013 Goldfine AB, Buck JS, Desouza C, Fonseca V, Chen YD, Shoelson SE, Jablonski KA, Creager MA. Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD). Diabetes Care. 36: 4132-9. PMID 24130358 DOI: 10.2337/Dc13-0859  0.64
2013 Romeo GR, Pae M, Eberlé D, Lee J, Shoelson SE. Profilin-1 haploinsufficiency protects against obesity-associated glucose intolerance and preserves adipose tissue immune homeostasis. Diabetes. 62: 3718-26. PMID 23884883 DOI: 10.2337/Db13-0050  0.64
2013 Goldfine AB, Fonseca V, Jablonski KA, Chen YD, Tipton L, Staten MA, Shoelson SE. Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial. Annals of Internal Medicine. 159: 1-12. PMID 23817699 DOI: 10.7326/0003-4819-159-1-201307020-00003  0.64
2013 Goldfine AB, Conlin PR, Halperin F, Koska J, Permana P, Schwenke D, Shoelson SE, Reaven PD. A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia. 56: 714-23. PMID 23370525 DOI: 10.1007/S00125-012-2819-3  0.64
2013 King AJF, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC. Blood glucose levels in STZ diabetic male C57BL/6AF1 mice transplanted with 150 fresh islets with administration of salicylate in the water (closed triangles) or regular water (open triangles). Plos One. DOI: 10.1371/Journal.Pone.0077452.G005  0.56
2012 Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, Li Q, Mizutani K, Yu E, Shimada T, Lee J, Shoelson SE, Jobin C, Rask-Madsen C, King GL. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Investigative Ophthalmology & Visual Science. 53: 8424-32. PMID 23197686 DOI: 10.1167/Iovs.12-10207  0.64
2012 Romeo GR, Lee J, Shoelson SE. Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 1771-6. PMID 22815343 DOI: 10.1161/Atvbaha.111.241869  0.64
2012 Schakman O, Dehoux M, Bouchuari S, Delaere S, Lause P, Decroly N, Shoelson SE, Thissen JP. Role of IGF-I and the TNFα/NF-κB pathway in the induction of muscle atrogenes by acute inflammation. American Journal of Physiology. Endocrinology and Metabolism. 303: E729-39. PMID 22739109 DOI: 10.1152/Ajpendo.00060.2012  0.64
2012 Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, Benoist C, Mathis D. PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 486: 549-53. PMID 22722857 DOI: 10.1038/Nature11132  0.64
2012 Langen RC, Haegens A, Vernooy JH, Wouters EF, de Winther MP, Carlsen H, Steele C, Shoelson SE, Schols AM. NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy. American Journal of Respiratory Cell and Molecular Biology. 47: 288-97. PMID 22538866 DOI: 10.1165/Rcmb.2011-0119Oc  0.64
2012 Haegens A, Schols AM, Gorissen SH, van Essen AL, Snepvangers F, Gray DA, Shoelson SE, Langen RC. NF-κB activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy. American Journal of Physiology. Lung Cellular and Molecular Physiology. 302: L103-10. PMID 22003096 DOI: 10.1152/Ajplung.00084.2011  0.64
2012 Wong MC, van Diepen JA, Hu L, Guigas B, de Boer HC, van Puijvelde GH, Kuiper J, van Zonneveld AJ, Shoelson SE, Voshol PJ, Romijn JA, Havekes LM, Tamsma JT, Rensen PC, Hiemstra PS, et al. Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice. Atherosclerosis. 220: 362-8. PMID 21798539 DOI: 10.1016/J.Atherosclerosis.2011.06.055  0.64
2012 Woo JR, Kim S, Shoelson SE, Park SY. X-ray crystallographic structure of TIR-domain from the human TIR-domain containing adaptor protein/MyD88-adaptor-like protein (TIRAP/MAL) Bulletin of the Korean Chemical Society. 33: 3091-3094. DOI: 10.2210/Pdb4Fz5/Pdb  0.64
2011 van Diepen JA, Vroegrijk IO, Berbée JF, Shoelson SE, Romijn JA, Havekes LM, Rensen PC, Voshol PJ. Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet. American Journal of Physiology. Endocrinology and Metabolism. 301: E1099-107. PMID 21862721 DOI: 10.1152/Ajpendo.00185.2011  0.64
2011 Mathis D, Shoelson SE. Immunometabolism: an emerging frontier. Nature Reviews. Immunology. 11: 81. PMID 21469396 DOI: 10.1038/Nri2922  0.64
2011 Park SY, Jin W, Woo JR, Shoelson SE. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. The Journal of Biological Chemistry. 286: 18130-8. PMID 21454505 DOI: 10.1074/Jbc.M110.217323  0.64
2011 van Diepen JA, Wong MC, Guigas B, Bos J, Stienstra R, Hodson L, Shoelson SE, Berbée JF, Rensen PC, Romijn JA, Havekes LM, Voshol PJ. Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice. Journal of Lipid Research. 52: 942-50. PMID 21357939 DOI: 10.1194/Jlr.M010405  0.64
2011 Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nature Reviews. Immunology. 11: 98-107. PMID 21233852 DOI: 10.1038/Nri2925  0.64
2011 Goldfine AB, Fonseca V, Shoelson SE. Therapeutic approaches to target inflammation in type 2 diabetes. Clinical Chemistry. 57: 162-7. PMID 21098138 DOI: 10.1373/Clinchem.2010.148833  0.64
2010 Goldfine AB, Fonseca V, Jablonski KA, Pyle L, Staten MA, Shoelson SE. The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Annals of Internal Medicine. 152: 346-57. PMID 20231565 DOI: 10.7326/0003-4819-152-6-201003160-00004  0.64
2010 Naour N, Rouault C, Fellahi S, Lavoie ME, Poitou C, Keophiphath M, Eberlé D, Shoelson S, Rizkalla S, Bastard JP, Rabasa-Lhoret R, Clement K, Guerre-Millo M. Cathepsins in human obesity: Changes in energy balance predominantly affect cathepsin S in adipose tissue and in circulation Journal of Clinical Endocrinology and Metabolism. 95: 1861-1868. PMID 20164293 DOI: 10.1210/Mend.24.3.9998  0.64
2010 Herrero L, Shapiro H, Nayer A, Lee J, Shoelson SE. Inflammation and adipose tissue macrophages in lipodystrophic mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 240-5. PMID 20007767 DOI: 10.1073/Pnas.0905310107  0.64
2009 Rha GB, Wu G, Shoelson SE, Chi YI. Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation. The Journal of Biological Chemistry. 284: 35165-76. PMID 19846556 DOI: 10.1074/Jbc.M109.052506  0.64
2009 Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nature Medicine. 15: 930-9. PMID 19633656 DOI: 10.1038/Nm.2002  0.64
2009 Goldfine AB, Shoelson SE, Aguirre V. Expansion and contraction: treating diabetes with bariatric surgery. Nature Medicine. 15: 616-7. PMID 19498374 DOI: 10.1038/Nm0609-616  0.64
2009 Shoelson SE, Goldfine AB. Getting away from glucose: fanning the flames of obesity-induced inflammation. Nature Medicine. 15: 373-4. PMID 19350009 DOI: 10.1038/Nm0409-373  0.64
2008 Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clinical and Translational Science. 1: 36-43. PMID 19337387 DOI: 10.1111/J.1752-8062.2008.00026.X  0.64
2008 Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. 105: 15878-83. PMID 18840680 DOI: 10.1073/Pnas.0808470105  0.64
2008 Park SY, Shoelson SE. When a domain is not a domain. Nature Structural & Molecular Biology. 15: 224-6. PMID 18319738 DOI: 10.1038/Nsmb0308-224  0.64
2008 Fleischman A, Shoelson SE, Bernier R, Goldfine AB. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care. 31: 289-94. PMID 17959861 DOI: 10.2337/Dc07-1338  0.64
2007 Abedini A, Shoelson SE. Inflammation and obesity: STAMPing out insulin resistance? Immunology and Cell Biology. 85: 399-400. PMID 17646847 DOI: 10.1038/Sj.Icb.7100107  0.64
2007 Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology. 132: 2169-80. PMID 17498510 DOI: 10.1053/J.Gastro.2007.03.059  0.64
2007 Boonyasrisawat W, Eberle D, Bacci S, Zhang YY, Nolan D, Gervino EV, Johnstone MT, Trischitta V, Shoelson SE, Doria A. Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes. Diabetes. 56: 499-505. PMID 17259397 DOI: 10.2337/Db06-0946  0.64
2006 Shoelson SE. Banking on ATM as a new target in metabolic syndrome. Cell Metabolism. 4: 337-8. PMID 17084707 DOI: 10.1016/J.Cmet.2006.10.009  0.64
2006 Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. The Journal of Clinical Investigation. 116: 1793-801. PMID 16823477 DOI: 10.1172/Jci29069  0.64
2005 Ho RC, Hirshman MF, Li Y, Cai D, Farmer JR, Aschenbach WG, Witczak CA, Shoelson SE, Goodyear LJ. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. American Journal of Physiology. Cell Physiology. 289: C794-801. PMID 15888549 DOI: 10.1152/Ajpcell.00632.2004  0.64
2005 Nishi M, Werner ED, Oh BC, Frantz JD, Dhe-Paganon S, Hansen L, Lee J, Shoelson SE. Kinase activation through dimerization by human SH2-B. Molecular and Cellular Biology. 25: 2607-21. PMID 15767667 DOI: 10.1128/Mcb.25.7.2607-2621.2005  0.64
2005 Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nature Medicine. 11: 183-90. PMID 15685173 DOI: 10.1038/Nm1166  0.64
2004 Cai D, Frantz JD, Tawa NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 119: 285-98. PMID 15479644 DOI: 10.1016/J.Cell.2004.09.027  0.64
2004 Dhe-Paganon S, Werner ED, Nishi M, Hansen L, Chi YI, Shoelson SE. A phenylalanine zipper mediates APS dimerization. Nature Structural & Molecular Biology. 11: 968-74. PMID 15378031 DOI: 10.1038/Nsmb829  0.64
2004 Werner ED, Lee J, Hansen L, Yuan M, Shoelson SE. Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. The Journal of Biological Chemistry. 279: 35298-305. PMID 15199052 DOI: 10.1074/Jbc.M405203200  0.64
2004 Duda K, Chi YI, Shoelson SE. Structural basis for HNF-4alpha activation by ligand and coactivator binding. The Journal of Biological Chemistry. 279: 23311-6. PMID 14982928 DOI: 10.1074/Jbc.M400864200  0.64
2003 Shoelson SE, Lee J, Yuan M. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. 27: S49-52. PMID 14704745 DOI: 10.1038/Sj.Ijo.0802501  0.64
2003 Cai D, Dhe-Paganon S, Melendez PA, Lee J, Shoelson SE. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. The Journal of Biological Chemistry. 278: 25323-30. PMID 12730241 DOI: 10.1074/Jbc.M212430200  0.64
2003 Kim KA, Kang K, Chi YI, Chang I, Lee MK, Kim KW, Shoelson SE, Lee MS. Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1alpha gene in a Korean family with MODY3. Diabetologia. 46: 721-7. PMID 12712243 DOI: 10.1007/S00125-003-1079-7  0.64
2003 Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ, Shoelson SE, Liu F. Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. The Journal of Biological Chemistry. 278: 8460-7. PMID 12493740 DOI: 10.1074/Jbc.M208518200  0.64
2002 Shoelson S. JMM - Past and present: Invited comment on W. Ebstein: On the therapy of diabetes mellitus, in particular on the application of sodium salicylate Journal of Molecular Medicine. 80: 618-619. PMID 12530411 DOI: 10.1007/S00109-002-0383-X  0.64
2002 Chi YI, Frantz JD, Oh BC, Hansen L, Dhe-Paganon S, Shoelson SE. Diabetes mutations delineate an atypical POU domain in HNF-1alpha. Molecular Cell. 10: 1129-37. PMID 12453420 DOI: 10.1016/S1097-2765(02)00704-9  0.64
2002 Rui L, Yuan M, Frantz D, Shoelson S, White MF. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 Journal of Biological Chemistry. 277: 42394-42398. PMID 12228220 DOI: 10.1074/Jbc.C200444200  0.64
2002 Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE. Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. The Journal of Biological Chemistry. 277: 37973-6. PMID 12193589 DOI: 10.1074/Jbc.C200420200  0.64
2002 Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. The Journal of Clinical Investigation. 109: 1321-6. PMID 12021247 DOI: 10.1172/Jci14955  0.64
2002 Menzaghi C, Plengvidhya N, Ma X, Warram JH, Shoelson SE, Doria A. Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism. 87: 1894-7. PMID 11932336 DOI: 10.1210/Jcem.87.4.8440  0.64
2002 Dhe-Paganon S, Werner ED, Chi YI, Shoelson SE. Structure of the globular tail of nuclear lamin. The Journal of Biological Chemistry. 277: 17381-4. PMID 11901143 DOI: 10.1074/Jbc.C200038200  0.64
2002 Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. The Journal of Biological Chemistry. 277: 1531-7. PMID 11606564 DOI: 10.1074/Jbc.M101521200  0.64
2001 Netea MG, Tack CJ, Netten PM, Lutterman JA, Van der Meer JWM, Kim JK, Shoelson SE, Shulman GI. The effect of salicylates on insulin sensitivity (multiple letters) Journal of Clinical Investigation. 108: 1723-1724. PMID 11733568  0.64
2001 Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science (New York, N.Y.). 293: 1673-7. PMID 11533494 DOI: 10.1126/Science.1061620  0.64
2001 Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI. Prevention of fat-induced insulin resistance by salicylate. The Journal of Clinical Investigation. 108: 437-46. PMID 11489937 DOI: 10.1172/Jci11559  0.64
2000 Lindholm CK, Frantz JD, Shoelson SE, Welsh M. Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. Biochemical and Biophysical Research Communications. 278: 537-43. PMID 11095946 DOI: 10.1006/Bbrc.2000.3847  0.64
2000 Dhe-Paganon S, Shigeta R, Chi YI, Ristow M, Shoelson SE. Crystal structure of human frataxin. The Journal of Biological Chemistry. 275: 30753-6. PMID 10900192 DOI: 10.1074/Jbc.C000407200  0.64
2000 O'Reilly AM, Pluskey S, Shoelson SE, Neel BG. Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Molecular and Cellular Biology. 20: 299-311. PMID 10594032 DOI: 10.1128/Mcb.20.1.299-311.2000  0.64
1999 Dhe-Paganon S, Ottinger EA, Nolte RT, Eck MJ, Shoelson SE. Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1. Proceedings of the National Academy of Sciences of the United States of America. 96: 8378-83. PMID 10411883 DOI: 10.1073/Pnas.96.15.8378  0.64
1998 Bjørbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS. Identification of SOCS-3 as a potential mediator of central leptin resistance. Molecular Cell. 1: 619-25. PMID 9660946 DOI: 10.1016/S1097-2765(00)80062-3  0.64
1998 Rapoport I, Chen YC, Cupers P, Shoelson SE, Kirchhausen T. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site. The Embo Journal. 17: 2148-55. PMID 9545228 DOI: 10.1093/Emboj/17.8.2148  0.64
1998 Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE. Crystal structure of the tyrosine phosphatase SHP-2. Cell. 92: 441-50. PMID 9491886 DOI: 10.1016/S0092-8674(00)80938-1  0.64
1998 Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. Oncogene. 16: 891-901. PMID 9484780 DOI: 10.1038/Sj.Onc.1201607  0.64
1998 Kay LE, Muhandiram DR, Wolf G, Shoelson SE, Forman-Kay JD. Correlation between binding and dynamics at SH2 domain interfaces. Nature Structural Biology. 5: 156-63. PMID 9461082 DOI: 10.1038/Nsb0298-156  0.64
1998 Ottinger EA, Botfield MC, Shoelson SE. Tandem SH2 domains confer high specificity in tyrosine kinase signaling. The Journal of Biological Chemistry. 273: 729-35. PMID 9422724 DOI: 10.1074/Jbc.273.2.729  0.64
1997 Shoelson SE. SH2 and PTB domain interactions in tyrosine kinase signal transduction. Current Opinion in Chemical Biology. 1: 227-34. PMID 9667855 DOI: 10.1016/S1367-5931(97)80014-2  0.64
1997 Lupher ML, Songyang Z, Shoelson SE, Cantley LC, Band H. The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. The Journal of Biological Chemistry. 272: 33140-4. PMID 9407100 DOI: 10.1074/Jbc.272.52.33140  0.64
1997 Rapoport I, Miyazaki M, Boll W, Duckworth B, Cantley LC, Shoelson S, Kirchhausen T. Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes Embo Journal. 16: 2240-2250. PMID 9171339 DOI: 10.1093/Emboj/16.9.2240  0.64
1997 Lee J, Pilch PF, Shoelson SE, Scarlata SF. Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy. Biochemistry. 36: 2701-8. PMID 9054578 DOI: 10.1021/Bi961815G  0.64
1997 Giorgetti-Peraldi S, Ottinger E, Wolf G, Ye B, Burke TR, Shoelson SE. Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking. Molecular and Cellular Biology. 17: 1180-8. PMID 9032245 DOI: 10.1128/Mcb.17.3.1180  0.64
1997 Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE. Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. The Journal of Biological Chemistry. 272: 2659-67. PMID 9006901 DOI: 10.1074/Jbc.272.5.2659  0.64
1997 Trüb T, Frantz JD, Miyazaki M, Band H, Shoelson SE. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. The Journal of Biological Chemistry. 272: 894-902. PMID 8995379 DOI: 10.1074/Jbc.272.2.894  0.64
1997 Shoelson SE. Allosteric regulation and interdomain cross-talk in signaling proteins tandem domains Faseb Journal. 11: A875.  0.64
1996 Ricketts WA, Rose DW, Shoelson S, Olefsky JM. Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling Journal of Biological Chemistry. 271: 26165-26169. PMID 8824262 DOI: 10.1074/Jbc.271.42.26165  0.64
1996 Sawasdikosol S, Chang JH, Pratt JC, Wolf G, Shoelson SE, Burakoff SJ. Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. Journal of Immunology (Baltimore, Md. : 1950). 157: 110-6. PMID 8683103  0.64
1996 Burke TR, Ye B, Akamatsu M, Ford H, Yan X, Kole HK, Wolf G, Shoelson SE, Roller PP. 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. Journal of Medicinal Chemistry. 39: 1021-7. PMID 8676336 DOI: 10.1021/Jm950621G  0.64
1996 Pratt JC, Weiss M, Sieff CA, Shoelson SE, Burakoff SJ, Ravichandran KS. Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor. The Journal of Biological Chemistry. 271: 12137-40. PMID 8647804 DOI: 10.1074/Jbc.271.21.12137  0.64
1996 Eck MJ, Dhe-Paganon S, Trüb T, Nolte RT, Shoelson SE. Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell. 85: 695-705. PMID 8646778 DOI: 10.1016/S0092-8674(00)81236-2  0.64
1996 Ravichandran KS, Igras V, Shoelson SE, Fesik SW, Burakoff SJ. Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proceedings of the National Academy of Sciences of the United States of America. 93: 5275-80. PMID 8643566 DOI: 10.1073/Pnas.93.11.5275  0.64
1996 Reedquist KA, Fukazawa T, Panchamoorthy G, Langdon WY, Shoelson SE, Druker BJ, Band H. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. The Journal of Biological Chemistry. 271: 8435-42. PMID 8626543 DOI: 10.1074/Jbc.271.14.8435  0.64
1996 Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with fyn and Syk tyrosine kinases, Grb2 and she adaptors, and the p85 subunit of phosphatidylinositol 3-kinase Journal of Biological Chemistry. 271: 3187-3194. PMID 8621719 DOI: 10.1074/Jbc.271.6.3187  0.64
1996 Zhou MM, Huang B, Olejniczak ET, Meadows RP, Shuker SB, Miyazaki M, Trüb T, Shoelson SE, Fesik SW. Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nature Structural Biology. 3: 388-93. PMID 8599766 DOI: 10.1038/Nsb0496-388  0.64
1996 Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC. Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes. Nature Structural Biology. 3: 364-74. PMID 8599763 DOI: 10.1038/Nsb0496-364  0.64
1996 Eck MJ, Pluskey S, Trüb T, Harrison SC, Shoelson SE. Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2. Nature. 379: 277-80. PMID 8538796 DOI: 10.1038/379277A0  0.64
1995 Sabe H, Shoelson SE, Hanafusa H. Possible v-Crk-induced transformation through activation of Src kinases. The Journal of Biological Chemistry. 270: 31219-24. PMID 8537387 DOI: 10.1074/Jbc.270.52.31219  0.64
1995 Lee J, Shoelson SE, Pilch PF. Intermolecular phosphorylation between insulin holoreceptors does not stimulate substrate kinase activity. The Journal of Biological Chemistry. 270: 31136-40. PMID 8537376 DOI: 10.1074/Jbc.270.52.31136  0.64
1995 Yamada K, Carpentier JL, Cheatham B, Goncalves E, Shoelson SE, Kahn CR. Role of the transmembrane domain and flanking amino acids in internalization and down-regulation of the insulin receptor. The Journal of Biological Chemistry. 270: 3115-22. PMID 7852393 DOI: 10.1074/Jbc.270.7.3115  0.64
1995 Schneider H, Prasad KV, Shoelson SE, Rudd CE. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. The Journal of Experimental Medicine. 181: 351-5. PMID 7807015 DOI: 10.1084/Jem.181.1.351  0.64
1995 Schneider H, Cai YC, Prasad KV, Shoelson SE, Rudd CE. T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras. European Journal of Immunology. 25: 1044-50. PMID 7737275 DOI: 10.1002/Eji.1830250428  0.64
1995 Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B, Cantley L, Shoelson SE, Band H. The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. The Journal of Biological Chemistry. 270: 19141-50. PMID 7642581 DOI: 10.1074/Jbc.270.32.19141  0.64
1995 Fukazawa T, Reedquist KA, Panchamoorthy G, Soltoff S, Trub T, Druker B, Cantley L, Shoelson SE, Band H. T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38. The Journal of Biological Chemistry. 270: 20177-82. PMID 7544353 DOI: 10.1074/Jbc.270.34.20177  0.64
1995 Trüb T, Choi WE, Wolf G, Ottinger E, Chen Y, Weiss M, Shoelson SE. Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine. The Journal of Biological Chemistry. 270: 18205-8. PMID 7543098 DOI: 10.1074/Jbc.270.31.18205  0.64
1995 Songyang Z, Margolis B, Chaudhuri M, Shoelson SE, Cantley LC. The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif. The Journal of Biological Chemistry. 270: 14863-6. PMID 7541030 DOI: 10.1074/Jbc.270.25.14863  0.64
1995 Burke TR, Barchi JJ, George C, Wolf G, Shoelson SE, Yan X. Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors. Journal of Medicinal Chemistry. 38: 1386-96. PMID 7537333 DOI: 10.1021/Jm00008A017  0.64
1995 Pluskey S, Wandless TJ, Walsh CT, Shoelson SE. Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. The Journal of Biological Chemistry. 270: 2897-900. PMID 7531695 DOI: 10.1074/Jbc.270.7.2897  0.64
1995 Ravichandran KS, Lorenz U, Shoelson SE, Burakoff SJ. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS. Molecular and Cellular Biology. 15: 593-600. PMID 7529871 DOI: 10.1128/Mcb.15.2.593  0.64
1995 Wolf G, Trüb T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J, Shoelson SE. PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. The Journal of Biological Chemistry. 270: 27407-10. PMID 7499194 DOI: 10.1074/Jbc.270.46.27407  0.64
1995 Ravichandran KS, Lorenz U, Shoelson SE, Burakoff SJ. Interaction of Shc with Grb2 regulates the Grb2 association with mSOS. Annals of the New York Academy of Sciences. 766: 202-3. PMID 7486657 DOI: 10.1111/J.1749-6632.1995.Tb26663.X  0.64
1995 Ye B, Akamatsu M, Shoelson SE, Wolf G, Giorgetti-Peraldi S, Yan X, Roller PP, Burke TR. L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. Journal of Medicinal Chemistry. 38: 4270-5. PMID 7473554 DOI: 10.1021/Jm00021A016  0.64
1994 Payne G, Stolz LA, Pei D, Band H, Shoelson SE, Walsh CT. The phosphopeptide-binding specificity of Src family SH2 domains. Chemistry & Biology. 1: 99-105. PMID 9383377 DOI: 10.1016/1074-5521(94)90047-7  0.64
1994 Pascal SM, Singer AU, Gish G, Yamazaki T, Shoelson SE, Pawson T, Kay LE, Forman-Kay JD. Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell. 77: 461-72. PMID 8181064 DOI: 10.1016/0092-8674(94)90160-0  0.64
1994 Prasad KV, Cai YC, Raab M, Duckworth B, Cantley L, Shoelson SE, Rudd CE. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proceedings of the National Academy of Sciences of the United States of America. 91: 2834-8. PMID 8146197 DOI: 10.1073/Pnas.91.7.2834  0.64
1994 Case RD, Piccione E, Wolf G, Benett AM, Lechleider RJ, Neel BG, Shoelson SE. SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides. The Journal of Biological Chemistry. 269: 10467-74. PMID 8144631  0.64
1994 Xiao S, Rose DW, Sasaoka T, Maegawa H, Burke TR, Roller PP, Shoelson SE, Olefsky JM. Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. The Journal of Biological Chemistry. 269: 21244-8. PMID 8063747  0.64
1994 Burke TR, Nomizu M, Otaka A, Smyth MS, Roller PP, Case RD, Wolf G, Shoelson SE. Cyclic peptide inhibitors of phosphatidylinositol 3-kinase p85 SH2 domain binding. Biochemical and Biophysical Research Communications. 201: 1148-53. PMID 8024556 DOI: 10.1006/Bbrc.1994.1825  0.64
1994 Li SC, Deber CM, Shoelson SE. An irregularity in the transmembrane domain helix correlates with the rate of insulin receptor internalization. Biochemistry. 33: 14333-8. PMID 7947843 DOI: 10.1021/Bi00251A047  0.64
1994 Garcia P, Shoelson SE, Drew JS, Miller WT. Phosphopeptide occupancy and photoaffinity cross-linking of the v-Src SH2 domain attenuates tyrosine kinase activity. The Journal of Biological Chemistry. 269: 30574-9. PMID 7527032  0.64
1994 Lee CH, Kominos D, Jacques S, Margolis B, Schlessinger J, Shoelson SE, Kuriyan J. Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure (London, England : 1993). 2: 423-38. PMID 7521735 DOI: 10.1016/S0969-2126(00)00044-7  0.64
1994 Burke TR, Smyth MS, Otaka A, Nomizu M, Roller PP, Wolf G, Case R, Shoelson SE. Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors. Biochemistry. 33: 6490-4. PMID 7515682 DOI: 10.1021/Bi00187A015  0.64
1994 Reedquist KA, Fukazawa T, Druker B, Panchamoorthy G, Shoelson SE, Band H. Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 91: 4135-9. PMID 7514295 DOI: 10.1073/Pnas.91.10.4135  0.64
1994 Sugimoto S, Wandless TJ, Shoelson SE, Neel BG, Walsh CT. Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. The Journal of Biological Chemistry. 269: 13614-22. PMID 7513703  0.64
1994 Eck MJ, Atwell SK, Shoelson SE, Harrison SC. Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature. 368: 764-9. PMID 7512222 DOI: 10.1038/368764A0  0.64
1994 Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Molecular and Cellular Biology. 14: 2777-85. PMID 7511210 DOI: 10.1128/Mcb.14.4.2777  0.64
1994 Roller PP, Otaka A, Nomizu M, Smyth MS, Barchi JJ, Burke TR, Case RD, Wolf G, Shoelson SE. Norleucine as a replacement for methionine in phosphatase-resistant linear and cyclic peptides which bind to p85 SH2 domains Bioorganic and Medicinal Chemistry Letters. 4: 1879-1882. DOI: 10.1016/S0960-894X(01)80389-9  0.64
1993 Lee J, O'Hare T, Pilch PF, Shoelson SE. Insulin receptor autophosphorylation occurs asymmetrically. The Journal of Biological Chemistry. 268: 4092-8. PMID 8440700  0.64
1993 Hua QX, Shoelson SE, Inouye K, Weiss MA. Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America. 90: 582-6. PMID 8421693 DOI: 10.1073/Pnas.90.2.582  0.64
1993 Chuang LM, Myers MG, Backer JM, Shoelson SE, White MF, Birnbaum MJ, Kahn CR. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase. Molecular and Cellular Biology. 13: 6653-60. PMID 8413261 DOI: 10.1128/Mcb.13.11.6653  0.64
1993 Goncalves E, Yamada K, Thatte HS, Backer JM, Golan DE, Kahn CR, Shoelson SE. Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility. Proceedings of the National Academy of Sciences of the United States of America. 90: 5762-6. PMID 8390680 DOI: 10.1073/Pnas.90.12.5762  0.64
1993 Backer JM, Myers MG, Sun XJ, Chin DJ, Shoelson SE, Miralpeix M, White MF. Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. The Journal of Biological Chemistry. 268: 8204-12. PMID 8385139  0.64
1993 Shoelson SE, Lee J, Lynch CS, Backer JM, Pilch PF. BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor. The Journal of Biological Chemistry. 268: 4085-91. PMID 8382690  0.64
1993 Shoelson SE, Sivaraja M, Williams KP, Hu P, Schlessinger J, Weiss MA. Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation. The Embo Journal. 12: 795-802. PMID 8382612 DOI: 10.1002/J.1460-2075.1993.Tb05714.X  0.64
1993 Garcia P, Shoelson SE, George ST, Hinds DA, Goldberg AR, Miller WT. Phosphorylation of synthetic peptides containing Tyr-Met-X-Met motifs by nonreceptor tyrosine kinases in vitro. The Journal of Biological Chemistry. 268: 25146-51. PMID 8227078  0.64
1993 Sugimoto S, Lechleider RJ, Shoelson SE, Neel BG, Walsh CT. Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. The Journal of Biological Chemistry. 268: 22771-6. PMID 8226787  0.64
1993 Williams KP, Shoelson SE. Cooperative self-assembly of SH2 domain fragments restores phosphopeptide binding. Biochemistry. 32: 11279-84. PMID 7692962 DOI: 10.1021/Bi00093A003  0.64
1993 Lechleider RJ, Sugimoto S, Bennett AM, Kashishian AS, Cooper JA, Shoelson SE, Walsh CT, Neel BG. Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. The Journal of Biological Chemistry. 268: 21478-81. PMID 7691811  0.64
1993 Cheatham B, Shoelson SE, Yamada K, Goncalves E, Kahn CR. Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1. Proceedings of the National Academy of Sciences of the United States of America. 90: 7336-40. PMID 7688476 DOI: 10.1073/Pnas.90.15.7336  0.64
1993 Birge RB, Fajardo JE, Reichman C, Shoelson SE, Songyang Z, Cantley LC, Hanafusa H. Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Molecular and Cellular Biology. 13: 4648-56. PMID 7687742 DOI: 10.1128/Mcb.13.8.4648  0.64
1993 Payne G, Shoelson SE, Gish GD, Pawson T, Walsh CT. Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. Proceedings of the National Academy of Sciences of the United States of America. 90: 4902-6. PMID 7685110 DOI: 10.1073/Pnas.90.11.4902  0.64
1993 Waksman G, Shoelson SE, Pant N, Cowburn D, Kuriyan J. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell. 72: 779-90. PMID 7680960 DOI: 10.1016/0092-8674(93)90405-F  0.64
1993 Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ. SH2 domains recognize specific phosphopeptide sequences. Cell. 72: 767-78. PMID 7680959 DOI: 10.1016/0092-8674(93)90404-E  0.64
1993 Williams KP, Shoelson SE. A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding. The Journal of Biological Chemistry. 268: 5361-4. PMID 7680644  0.64
1993 Eck MJ, Shoelson SE, Harrison SC. Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature. 362: 87-91. PMID 7680435 DOI: 10.1038/362087A0  0.64
1993 Kahn CR, White MF, Shoelson SE, Backer JM, Araki E, Cheatham B, Csermely P, Folli F, Goldstein BJ, Huertas P. The insulin receptor and its substrate: molecular determinants of early events in insulin action. Recent Progress in Hormone Research. 48: 291-339. PMID 7680139 DOI: 10.1016/B978-0-12-571148-7.50015-4  0.64
1993 Felder S, Zhou M, Hu P, Ureña J, Ullrich A, Chaudhuri M, White M, Shoelson SE, Schlessinger J. SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange. Molecular and Cellular Biology. 13: 1449-55. PMID 7680095 DOI: 10.1128/Mcb.13.3.1449  0.64
1992 Shoelson SE, Lu ZX, Parlautan L, Lynch CS, Weiss MA. Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions. Biochemistry. 31: 1757-67. PMID 1737029 DOI: 10.1021/Bi00121A025  0.64
1992 Backer JM, Shoelson SE, Weiss MA, Hua QX, Cheatham RB, Haring E, Cahill DC, White MF. The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals. The Journal of Cell Biology. 118: 831-9. PMID 1500426 DOI: 10.1083/Jcb.118.4.831  0.64
1992 Hua QX, Shoelson SE, Weiss MA. Nonlocal structural perturbations in a mutant human insulin: sequential resonance assignment and 13C-isotope-aided 2D-NMR studies of [PheB24-->Gly]insulin with implications for receptor recognition. Biochemistry. 31: 11940-51. PMID 1445924 DOI: 10.1021/Bi00162A037  0.64
1992 Rhodes CJ, Lincoln B, Shoelson SE. Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing. The Journal of Biological Chemistry. 267: 22719-27. PMID 1429623  0.64
1992 Meyerovitch J, Backer JM, Csermely P, Shoelson SE, Kahn CR. Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells. Biochemistry. 31: 10338-44. PMID 1420153 DOI: 10.1021/Bi00157A023  0.64
1992 Domchek SM, Auger KR, Chatterjee S, Burke TR, Shoelson SE. Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide. Biochemistry. 31: 9865-70. PMID 1382595 DOI: 10.1021/Bi00156A002  0.64
1992 Backer JM, Myers MG, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J. Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. The Embo Journal. 11: 3469-79. PMID 1380456 DOI: 10.1002/J.1460-2075.1992.Tb05426.X  0.64
1992 Auger KR, Carpenter CL, Shoelson SE, Piwnica-Worms H, Cantley LC. Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. The Journal of Biological Chemistry. 267: 5408-15. PMID 1372000  0.64
1992 Yamada K, Goncalves E, Kahn CR, Shoelson SE. Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro. The Journal of Biological Chemistry. 267: 12452-61. PMID 1352286  0.64
1992 Myers MG, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proceedings of the National Academy of Sciences of the United States of America. 89: 10350-4. PMID 1332046 DOI: 10.1073/Pnas.89.21.10350  0.64
1992 Shoelson SE, Chatterjee S, Chaudhuri M, White MF. YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. Proceedings of the National Academy of Sciences of the United States of America. 89: 2027-31. PMID 1312712 DOI: 10.1073/Pnas.89.6.2027  0.64
1991 Hua QX, Shoelson SE, Kochoyan M, Weiss MA. Receptor binding redefined by a structural switch in a mutant human insulin. Nature. 354: 238-41. PMID 1961250 DOI: 10.1038/354238A0  0.64
1991 Weiss MA, Hua QX, Lynch CS, Frank BH, Shoelson SE. Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design. Biochemistry. 30: 7373-89. PMID 1906742 DOI: 10.1021/Bi00244A004  0.52
1991 Backer JM, Shoelson SE, Haring E, White MF. Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region. The Journal of Cell Biology. 115: 1535-45. PMID 1757462 DOI: 10.1083/Jcb.115.6.1535  0.64
1991 Shoelson SE, Boni-Schnetzler M, Pilch PF, Kahn CR. Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process. Biochemistry. 30: 7740-6. PMID 1651107 DOI: 10.1021/bi00245a010  0.64
1991 Shoelson SE, Chatterjee S, Chaudhuri M, Burke TR. Solid-phase synthesis of nonhydrolyzable phosphotyrosyl peptide analogues with Nα-Fmoc-(O,O-di-t-butyl)phosphono-p-methylphenylalanine Tetrahedron Letters. 32: 6061-6064. DOI: 10.1016/0040-4039(91)80753-S  0.64
1990 Weiss MA, Frank BH, Khait I, Pekar A, Heiney R, Shoelson SE, Neuringer LJ. NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition. Biochemistry. 29: 8389-401. PMID 2252901 DOI: 10.1021/Bi00488A028  0.64
1989 Weiss MA, Nguyen DT, Khait I, Inouye K, Frank BH, Beckage M, O'Shea E, Shoelson SE, Karplus M, Neuringer LJ. Two-dimensional NMR and photo-CIDNP studies of the insulin monomer: assignment of aromatic resonances with application to protein folding, structure, and dynamics. Biochemistry. 28: 9855-73. PMID 2692717 DOI: 10.1021/Bi00451A046  0.64
1989 Shoelson SE, White MF, Kahn CR. Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases. The Journal of Biological Chemistry. 264: 7831-6. PMID 2498306  0.64
1988 Shoelson SE, White MF, Kahn CR. Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. The Journal of Biological Chemistry. 263: 4852-60. PMID 2832409  0.64
1988 Karasik A, Pepinsky RB, Shoelson SE, Kahn CR. Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver. The Journal of Biological Chemistry. 263: 11862-7. PMID 2457028  0.64
1988 White MF, Shoelson SE, Keutmann H, Kahn CR. A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. The Journal of Biological Chemistry. 263: 2969-80. PMID 2449432  0.64
1986 Shoelson SE, Polonsky KS, Nakabayashi T, Jaspan JB, Tager HS. Circulating forms of somatostatinlike immunoreactivity in human plasma. The American Journal of Physiology. 250: E428-34. PMID 3963183 DOI: 10.1152/Ajpendo.1986.250.4.E428  0.64
1986 Halban PA, Rhodes CJ, Shoelson SE. High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin. Diabetologia. 29: 893-6. PMID 3552815 DOI: 10.1007/Bf00870146  0.64
1986 Shoelson SE, Marshall S, Horikoshi H, Kolterman OG, Rubenstein AH, Olefsky JM. Antiinsulin receptor antibodies in an insulin-dependent diabetic may arise as autoantiidiotypes. The Journal of Clinical Endocrinology and Metabolism. 63: 56-61. PMID 3486878 DOI: 10.1210/Jcem-63-1-56  0.64
1985 Given BD, Cohen RM, Shoelson SE, Frank BH, Rubenstein AH, Tager HS. Biochemical and clinical implications of proinsulin conversion intermediates. The Journal of Clinical Investigation. 76: 1398-405. PMID 3902891 DOI: 10.1172/Jci112116  0.64
1985 Robbins DC, Shoelson SE, Tager HS, Mead PM, Gaynor DH. Products of therapeutic insulins in the blood of insulin-dependent (type I) diabetic patients. Diabetes. 34: 510-9. PMID 3886464 DOI: 10.2337/Diab.34.5.510  0.64
1985 Cohen RM, Nakabayashi T, Blix PM, Rue PA, Shoelson SE, Root MA, Frank BH, Revers RR, Rubenstein AH. A radioimmunoassay for circulating human proinsulin. Diabetes. 34: 84-91. PMID 3880551 DOI: 10.2337/Diab.34.1.84  0.64
1984 Haneda M, Polonsky KS, Bergenstal RM, Jaspan JB, Shoelson SE, Blix PM, Chan SJ, Kwok SC, Wishner WB, Zeidler A. Familial hyperinsulinemia due to a structurally abnormal insulin. Definition of an emerging new clinical syndrome. The New England Journal of Medicine. 310: 1288-94. PMID 6371526 DOI: 10.1056/NEJM198405173102004  0.64
1984 Shoelson SE, Polonsky KS, Zeidler A, Rubenstein AH, Tager HS. Human insulin B24 (Phe----Ser). Secretion and metabolic clearance of the abnormal insulin in man and in a dog model. The Journal of Clinical Investigation. 73: 1351-8. PMID 6371057 DOI: 10.1172/Jci111338  0.64
1984 Robbins DC, Shoelson SE, Rubenstein AH, Tager HS. Familial hyperproinsulinemia. Two cohorts secreting indistinguishable type II intermediates of proinsulin conversion. The Journal of Clinical Investigation. 73: 714-9. PMID 6368587 DOI: 10.1172/Jci111264  0.64
1983 Shoelson S, Fickova M, Haneda M, Nahum A, Musso G, Kaiser ET, Rubenstein AH, Tager H. Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution. Proceedings of the National Academy of Sciences of the United States of America. 80: 7390-4. PMID 6424111 DOI: 10.1073/Pnas.80.24.7390  0.64
1983 Shoelson S, Haneda M, Blix P, Nanjo A, Sanke T, Inouye K, Steiner D, Rubenstein A, Tager H. Three mutant insulins in man Nature. 302: 540-543. PMID 6339950 DOI: 10.1038/302540A0  0.64
1983 Shoelson SE, Peters AL, Nakabayashi T, Polonsky KS. Responses of somatostatin components to oral glucose in human plasma. Transactions of the Association of American Physicians. 96: 113-21. PMID 6149644  0.64
1983 Polonsky KS, Shoelson SE, Docherty HM. Plasma somatostatin 28 increases in response to feeding in man. The Journal of Clinical Investigation. 71: 1514-8. PMID 6133883 DOI: 10.1172/Jci110907  0.64
1982 Shoelson S, Polonsky K, Docherty H, Jaspan J, Rubenstein A. Evidence for the presence of somatostatin 28 in plasma Diabetes. 31: 474-477. PMID 6130021 DOI: 10.2337/Diab.31.5.474  0.64
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