| Year |
Citation |
Score |
| 2020 |
Barrows RD, Hammill JT, Tran MC, Falade MO, Rice AL, Davis CW, Emge TJ, Rablen PR, Kiplin Guy R, Knapp S. Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio-thienopyrimidine (TTP) series of antimalarials. Bioorganic & Medicinal Chemistry. 28: 115758. PMID 33007559 DOI: 10.1016/j.bmc.2020.115758 |
0.44 |
|
| 2018 |
Barrows RD, Blacklock KM, Rablen PR, Khare SD, Knapp S. Computational assessment of thioether isosteres. Journal of Molecular Graphics & Modelling. 80: 282-292. PMID 29414047 DOI: 10.1016/j.jmgm.2018.01.018 |
0.44 |
|
| 2017 |
Polyak D, Phung N, Liu J, Barrows R, Emge TJ, Knapp S. Stereochemistry and Reactivity of the HPA-Imine Mannich Intermediate. Tetrahedron Letters. 58: 3879-3883. PMID 29276314 DOI: 10.1016/j.tetlet.2017.08.070 |
0.4 |
|
| 2016 |
Gebel J, Luh LM, Coutandin D, Osterburg C, Löhr F, Schäfer B, Frombach AS, Sumyk M, Buchner L, Krojer T, Salah E, Mathea S, Güntert P, Knapp S, Dötsch V. Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization. Cell Death and Differentiation. PMID 27716744 DOI: 10.1038/cdd.2016.83 |
0.64 |
|
| 2016 |
Popp TA, Tallant C, Rogers C, Fedorov O, Brennan PE, Müller S, Knapp S, Bracher F. Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors. Journal of Medicinal Chemistry. PMID 27673482 DOI: 10.1021/acs.jmedchem.6b00774 |
0.64 |
|
| 2016 |
Wittmann SK, Kalinowsky L, Kramer JS, Bloecher R, Knapp S, Steinhilber D, Pogoryelov D, Proschak E, Heering J. Thermodynamic properties of leukotriene A4 hydrolase inhibitors. Bioorganic & Medicinal Chemistry. PMID 27651294 DOI: 10.1016/j.bmc.2016.08.047 |
0.64 |
|
| 2016 |
Myrianthopoulos V, Gaboriaud-Kolar N, Tallant C, Hall ML, Grigoriou S, Brownlee PM, Fedorov O, Rogers C, Heidenreich D, Wanior M, Drosos N, Mexia N, Savitsky P, Bagratuni T, Kastritis E, ... ... Knapp S, et al. Discovery and optimization of a selective ligand for the Switch/Sucrose Non-Fermenting-related bromodomains of Polybromo protein-1 by the use of virtual screening and hydration analysis. Journal of Medicinal Chemistry. PMID 27617704 DOI: 10.1021/acs.jmedchem.6b00355 |
0.64 |
|
| 2016 |
Floyd DM, Stein P, Wang Z, Liu J, Castro S, Clark JA, Connelly MC, Zhu F, Holbrook G, Matheny A, Sigal MS, Min J, Dhinakara R, Krishnan S, Bashyam S, ... Knapp S, et al. Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides. Journal of Medicinal Chemistry. PMID 27505686 DOI: 10.1021/acs.jmedchem.6b00752 |
0.32 |
|
| 2016 |
Miranda F, Mannion D, Liu S, Zheng Y, Mangala LS, Redondo C, Herrero-Gonzalez S, Xu R, Taylor C, Chedom DF, Karaminejadranjbar M, Albukhari A, Jiang D, Pradeep S, Rodriguez-Aguayo C, ... ... Knapp S, et al. Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche. Cancer Cell. PMID 27478041 DOI: 10.1016/j.ccell.2016.06.020 |
0.64 |
|
| 2016 |
Lori L, Pasquo A, Lori C, Petrosino M, Chiaraluce R, Tallant C, Knapp S, Consalvi V. Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability. Plos One. 11: e0159180. PMID 27403962 DOI: 10.1371/journal.pone.0159180 |
0.64 |
|
| 2016 |
Chang AN, Mahajan P, Knapp S, Barton H, Sweeney HL, Kamm KE, Stull JT. Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities. Proceedings of the National Academy of Sciences of the United States of America. PMID 27325775 DOI: 10.1073/pnas.1600633113 |
0.64 |
|
| 2016 |
Montenegro RC, Clark PG, Howarth A, Wan X, Ceroni A, Siejka P, Nunez-Alonso GA, Monteiro O, Rogers C, Gamble V, Burbano R, Brennan PE, Tallant C, Ebner D, Fedorov O, ... ... Knapp S, et al. BET inhibition as a new strategy for the treatment of gastric cancer. Oncotarget. PMID 27259267 DOI: 10.18632/oncotarget.9766 |
0.64 |
|
| 2016 |
Milhas S, Raux B, Betzi S, Derviaux C, Roche P, Restouin A, Basse MJ, Rebuffet E, Lugari A, Badol M, Kashyap R, Lissitzky JC, Eydoux C, Hamon V, Gourdel ME, ... ... Knapp S, et al. Protein-protein interaction inhibition (2P2I)-oriented chemical library accelerates hit discovery. Acs Chemical Biology. PMID 27219844 DOI: 10.1021/acschembio.6b00286 |
0.64 |
|
| 2016 |
Sdelci S, Lardeau CH, Tallant C, Klepsch F, Klaiber B, Bennett J, Rathert P, Schuster M, Penz T, Fedorov O, Superti-Furga G, Bock C, Zuber J, Huber KV, Knapp S, et al. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. Nature Chemical Biology. PMID 27159579 DOI: 10.1038/nchembio.2080 |
0.64 |
|
| 2016 |
Lavogina D, Kestav K, Chaikuad A, Heroven C, Knapp S, Uri A. Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors. Acta Crystallographica. Section F, Structural Biology Communications. 72: 339-45. PMID 27139824 DOI: 10.1107/S2053230X16004611 |
0.64 |
|
| 2016 |
Esvan YJ, Zeinyeh W, Boibessot T, Nauton L, Théry V, Knapp S, Chaikuad A, Loaëc N, Meijer L, Anizon F, Giraud F, Moreau P. Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. European Journal of Medicinal Chemistry. 118: 170-177. PMID 27128181 DOI: 10.1016/j.ejmech.2016.04.004 |
0.64 |
|
| 2016 |
Sutherell CL, Tallant C, Monteiro OP, Yapp C, Fuchs JE, Fedorov O, Siejka P, Müller S, Knapp S, Brenton JD, Brennan PE, Ley SV. Identification and development of 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one inhibitors targeting bromodomains within the Switch/Sucrose Non-Fermenting complex. Journal of Medicinal Chemistry. PMID 27119626 DOI: 10.1021/acs.jmedchem.5b01997 |
0.64 |
|
| 2016 |
Gerstenberger BS, Trzupek JD, Tallant C, Fedorov O, Filippakopoulos P, Brennan PE, Fedele V, Martin S, Picaud S, Rogers CM, Parikh MD, Taylor A, Samas BM, O'Mahony A, Berg EL, ... ... Knapp S, et al. Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit. Journal of Medicinal Chemistry. PMID 27115555 DOI: 10.1021/acs.jmedchem.6b00012 |
0.64 |
|
| 2016 |
Coutandin D, Osterburg C, Srivastav RK, Sumyk M, Kehrloesser S, Gebel J, Tuppi M, Hannewald J, Schäfer B, Salah E, Mathea S, Müller-Kuller U, Doutch J, Grez M, Knapp S, et al. Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level. Elife. 5. PMID 27021569 DOI: 10.7554/eLife.13909 |
0.64 |
|
| 2016 |
Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S. Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib. Acs Chemical Biology. PMID 26999302 DOI: 10.1021/acschembio.6b00043 |
0.64 |
|
| 2016 |
Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB. Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response. Science Advances. 2: e1501257. PMID 26989780 DOI: 10.1126/sciadv.1501257 |
0.64 |
|
| 2016 |
Zhang Y, Knapp S. Glycosylation of Nucleosides. The Journal of Organic Chemistry. PMID 26938666 DOI: 10.1021/acs.joc.5b02852 |
0.52 |
|
| 2016 |
Zuercher WJ, Elkins JM, Knapp S. The Intersection of Structural and Chemical Biology - An Essential Synergy. Cell Chemical Biology. 23: 173-82. PMID 26933743 DOI: 10.1016/j.chembiol.2015.12.005 |
0.64 |
|
| 2016 |
Martin LJ, Koegl M, Bader G, Cockcroft XL, Fedorov O, Fiegen D, Gerstberger T, Hofmann MH, Hohmann AF, Kessler D, Knapp S, Knesl P, Kornigg S, Müller S, Nar H, et al. Structure-based design of an in vivo active selective BRD9 inhibitor. Journal of Medicinal Chemistry. PMID 26914985 DOI: 10.1021/acs.jmedchem.5b01865 |
0.64 |
|
| 2016 |
Sorrell FJ, Szklarz M, Abdul Azeez KR, Elkins JM, Knapp S. Family-wide Structural Analysis of Human Numb-Associated Protein Kinases. Structure (London, England : 1993). PMID 26853940 DOI: 10.1016/j.str.2015.12.015 |
0.64 |
|
| 2016 |
Aldeghi M, Heifetz A, Bodkin MJ, Knapp S, Biggin PC. Accurate calculation of the absolute free energy of binding for drug molecules. Chemical Science (Royal Society of Chemistry : 2010). 7: 207-218. PMID 26798447 DOI: 10.1039/c5sc02678d |
0.64 |
|
| 2016 |
Raux B, Voitovich Y, Derviaux C, Lugari A, Rebuffet E, Milhas S, Priet S, Roux T, Trinquet E, Guillemot JC, Knapp S, Brunel JM, Fedorov AY, Collette Y, Roche P, et al. Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. Journal of Medicinal Chemistry. PMID 26735842 DOI: 10.1021/acs.jmedchem.5b01708 |
0.64 |
|
| 2016 |
Chaikuad A, Lang S, Brennan PE, Temperini C, Fedorov O, Hollander J, Nachane R, Abell C, Müller S, Siegal G, Knapp S. Structure-based identification of inhibitory fragments targeting the p300/CBP-associated factor bromodomain. Journal of Medicinal Chemistry. PMID 26731131 DOI: 10.1021/acs.jmedchem.5b01719 |
0.64 |
|
| 2016 |
Petersen LK, Blakskjær P, Chaikuad A, Christensen AB, Dietvorst J, Holmkvist J, Knapp S, Kořínek M, Larsen LK, Pedersen AE, Röhm S, Sløk FA, Hansen NJV. Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library Medchemcomm. 7: 1332-1339. DOI: 10.1039/c6md00241b |
0.64 |
|
| 2015 |
Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Hing Che K, ... ... Knapp S, et al. Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy. Cancer Research. PMID 26552700 DOI: 10.1158/0008-5472.CAN-15-0236 |
0.64 |
|
| 2015 |
Knapp S. Emerging Target Families: Intractable Targets. Handbook of Experimental Pharmacology. PMID 26552403 DOI: 10.1007/164_2015_28 |
0.64 |
|
| 2015 |
Elkins JM, Fedele V, Szklarz M, Abdul Azeez KR, Salah E, Mikolajczyk J, Romanov S, Sepetov N, Huang XP, Roth BL, Al Haj Zen A, Fourches D, Muratov E, Tropsha A, Morris J, ... ... Knapp S, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nature Biotechnology. PMID 26501955 DOI: 10.1038/nbt.3374 |
0.64 |
|
| 2015 |
Müller S, Chaikuad A, Gray NS, Knapp S. The ins and outs of selective kinase inhibitor development. Nature Chemical Biology. 11: 818-21. PMID 26485069 DOI: 10.1038/nchembio.1938 |
0.64 |
|
| 2015 |
Morozumi Y, Boussouar F, Tan M, Chaikuad A, Jamshidikia M, Colak G, He H, Nie L, Petosa C, de Dieuleveult M, Curtet S, Vitte AL, Rabatel C, Debernardi A, Cosset FL, ... ... Knapp S, et al. Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells. Journal of Molecular Cell Biology. PMID 26459632 DOI: 10.1093/jmcb/mjv060 |
0.64 |
|
| 2015 |
Gato-Cañas M, Martinez de Morentin X, Blanco-Luquin I, Fernandez-Irigoyen J, Zudaire I, Liechtenstein T, Arasanz H, Lozano T, Casares N, Chaikuad A, Knapp S, Guerrero-Setas D, Escors D, Kochan G, Santamaría E. A core of kinase-regulated interactomes defines the neoplastic MDSC lineage. Oncotarget. 6: 27160-75. PMID 26320174 DOI: 10.18632/oncotarget.4746 |
0.64 |
|
| 2015 |
Huston A, Arrowsmith CH, Knapp S, Schapira M. Probing the epigenome. Nature Chemical Biology. 11: 542-5. PMID 26196765 DOI: 10.1038/nchembio.1871 |
0.64 |
|
| 2015 |
Alexander LT, Möbitz H, Drueckes P, Savitsky P, Fedorov O, Elkins JM, Deane CM, Cowan-Jacob SW, Knapp S. Type II Inhibitors Targeting CDK2. Acs Chemical Biology. PMID 26158339 DOI: 10.1021/acschembio.5b00398 |
0.64 |
|
| 2015 |
Hong J, Wang Z, Levin A, Emge TJ, Floyd DM, Knapp S. Dimerization and comments on the reactivity of homophthalic anhydride. Tetrahedron Letters. 56: 3001-3004. PMID 26124537 DOI: 10.1016/j.tetlet.2014.10.027 |
0.52 |
|
| 2015 |
Harrington L, Alexander LT, Knapp S, Bayley H. Pim Kinase Inhibitors Evaluated with a Single-Molecule Engineered Nanopore Sensor. Angewandte Chemie (International Ed. in English). PMID 26058458 DOI: 10.1002/anie.201503141 |
0.64 |
|
| 2015 |
Bennett J, Fedorov O, Tallant C, Monteiro O, Meier J, Gamble V, Savitsky P, Nunez-Alonso GA, Haendler B, Rogers C, Brennan PE, Müller S, Knapp S. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. Journal of Medicinal Chemistry. PMID 25974391 DOI: 10.1021/acs.jmedchem.5b00458 |
0.64 |
|
| 2015 |
Martin E, Knapp S, Engh RA, Moebitz H, Varin T, Roux B, Meiler J, Berdini V, Baumann A, Vieth M. Perspective on computational and structural aspects of kinase discovery from IPK2014. Biochimica Et Biophysica Acta. PMID 25861861 DOI: 10.1016/j.bbapap.2015.03.014 |
0.64 |
|
| 2015 |
Kovackova S, Chang L, Bekerman E, Neveu G, Barouch-Bentov R, Chaikuad A, Heroven C, Šála M, De Jonghe S, Knapp S, Einav S, Herdewijn P. Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents. Journal of Medicinal Chemistry. 58: 3393-410. PMID 25822739 DOI: 10.1021/jm501759m |
0.64 |
|
| 2015 |
Chen P, Chaikuad A, Bamborough P, Bantscheff M, Bountra C, Chung CW, Fedorov O, Grandi P, Jung D, Lesniak R, Lindon M, Müller S, Philpott M, Prinjha R, Rogers C, ... ... Knapp S, et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. Journal of Medicinal Chemistry. PMID 25799074 DOI: 10.1021/acs.jmedchem.5b00209 |
0.64 |
|
| 2015 |
Falke H, Chaikuad A, Becker A, Loaëc N, Lozach O, Abu Jhaisha S, Becker W, Jones PG, Preu L, Baumann K, Knapp S, Meijer L, Kunick C. 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. Journal of Medicinal Chemistry. 58: 3131-43. PMID 25730262 DOI: 10.1021/jm501994d |
0.64 |
|
| 2015 |
Drouin L, McGrath S, Vidler LR, Chaikuad A, Monteiro O, Tallant C, Philpott M, Rogers C, Fedorov O, Liu M, Akhtar W, Hayes A, Raynaud F, Müller S, Knapp S, et al. Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. Journal of Medicinal Chemistry. 58: 2553-9. PMID 25719566 DOI: 10.1021/jm501963e |
0.64 |
|
| 2015 |
Kestav K, Lavogina D, Raidaru G, Chaikuad A, Knapp S, Uri A. Bisubstrate inhibitor approach for targeting mitotic kinase Haspin. Bioconjugate Chemistry. 26: 225-34. PMID 25595038 DOI: 10.1021/bc500464r |
0.64 |
|
| 2015 |
Horne GA, Stewart HJ, Dickson J, Knapp S, Ramsahoye B, Chevassut T. Nanog requires BRD4 to maintain murine embryonic stem cell pluripotency and is suppressed by bromodomain inhibitor JQ1 together with Lefty1. Stem Cells and Development. 24: 879-91. PMID 25393219 DOI: 10.1089/scd.2014.0302 |
0.64 |
|
| 2015 |
Wilbek TS, Skovgaard T, Sorrell FJ, Knapp S, Berthelsen J, Strømgaard K. Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1. Chembiochem : a European Journal of Chemical Biology. 16: 59-63. PMID 25382253 DOI: 10.1002/cbic.201402512 |
0.64 |
|
| 2015 |
Hammitzsch A, Tallant C, Fedorov O, O'Mahony A, Brennan PE, Hay DA, Martinez FO, Al-Mossawi MH, De Wit J, Vecellio M, Wells C, Wordsworth P, Müller S, Knapp S, Bowness P. CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses Proceedings of the National Academy of Sciences of the United States of America. 112: 10768-10773. DOI: 10.1073/pnas.1501956112 |
0.64 |
|
| 2015 |
Ekambaram R, Manoharan GB, Enkvist E, Ligi K, Knapp S, Uri A. PIM kinase-responsive microsecond-lifetime photoluminescent probes based on selenium-containing heteroaromatic tricycle Rsc Advances. 5: 96750-96757. DOI: 10.1039/c5ra20777k |
0.64 |
|
| 2015 |
Filippakopoulos P, Knapp S. Genome-wide profiling of molecular recognition of histone PTMs Histone Recognition. 173-184. DOI: 10.1007/978-3-319-18102-8_8 |
0.64 |
|
| 2015 |
Toi M, Pillai MR, Gupta S, Badwe R, Carmo-Fonseca M, Costa L, Chow LWC, Knapp S, Kumar R. The global cancer genomics consortium’s symposium: New era of molecular medicine and epigenetic cancer medicine - Cross section of genomics and epigenetics Genes and Cancer. 6: 1-8. |
0.64 |
|
| 2014 |
Wang J, Knapp S, Pyne NJ, Pyne S, Elkins JM. Crystal Structure of Sphingosine Kinase 1 with PF-543. Acs Medicinal Chemistry Letters. 5: 1329-33. PMID 25516793 DOI: 10.1021/ml5004074 |
0.64 |
|
| 2014 |
Jiménez-Díaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, ... ... Knapp S, et al. (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proceedings of the National Academy of Sciences of the United States of America. 111: E5455-62. PMID 25453091 DOI: 10.1073/pnas.1414221111 |
0.32 |
|
| 2014 |
Chaikuad A, Tacconi EM, Zimmer J, Liang Y, Gray NS, Tarsounas M, Knapp S. A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics. Nature Chemical Biology. 10: 853-60. PMID 25195011 DOI: 10.1038/nchembio.1629 |
0.64 |
|
| 2014 |
Abdul Azeez KR, Knapp S, Fernandes JM, Klussmann E, Elkins JM. The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex. The Biochemical Journal. 464: 231-9. PMID 25186459 DOI: 10.1042/BJ20140606 |
0.64 |
|
| 2014 |
Knapp S, Sundström M. Recently targeted kinases and their inhibitors-the path to clinical trials. Current Opinion in Pharmacology. 17: 58-63. PMID 25113945 DOI: 10.1016/j.coph.2014.07.015 |
0.64 |
|
| 2014 |
Philpott M, Rogers CM, Yapp C, Wells C, Lambert JP, Strain-Damerell C, Burgess-Brown NA, Gingras AC, Knapp S, Müller S. Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching. Epigenetics & Chromatin. 7: 14. PMID 25097667 DOI: 10.1186/1756-8935-7-14 |
0.64 |
|
| 2014 |
Liu J, Wang Z, Levin A, Emge TJ, Rablen PR, Floyd DM, Knapp S. N-methylimidazole promotes the reaction of homophthalic anhydride with imines. The Journal of Organic Chemistry. 79: 7593-9. PMID 25036978 DOI: 10.1021/jo501316m |
0.52 |
|
| 2014 |
Nagarajan S, Hossan T, Alawi M, Najafova Z, Indenbirken D, Bedi U, Taipaleenmäki H, Ben-Batalla I, Scheller M, Loges S, Knapp S, Hesse E, Chiang CM, Grundhoff A, Johnsen SA. Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription. Cell Reports. 8: 460-9. PMID 25017071 DOI: 10.1016/j.celrep.2014.06.016 |
0.64 |
|
| 2014 |
Hay DA, Fedorov O, Martin S, Singleton DC, Tallant C, Wells C, Picaud S, Philpott M, Monteiro OP, Rogers CM, Conway SJ, Rooney TP, Tumber A, Yapp C, Filippakopoulos P, ... ... Knapp S, et al. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. Journal of the American Chemical Society. 136: 9308-19. PMID 24946055 DOI: 10.1021/ja412434f |
0.64 |
|
| 2014 |
Rudolf AF, Skovgaard T, Knapp S, Jensen LJ, Berthelsen J. A comparison of protein kinases inhibitor screening methods using both enzymatic activity and binding affinity determination. Plos One. 9: e98800. PMID 24915177 DOI: 10.1371/journal.pone.0098800 |
0.64 |
|
| 2014 |
Rooney TP, Filippakopoulos P, Fedorov O, Picaud S, Cortopassi WA, Hay DA, Martin S, Tumber A, Rogers CM, Philpott M, Wang M, Thompson AL, Heightman TD, Pryde DC, Cook A, ... ... Knapp S, et al. A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction. Angewandte Chemie (International Ed. in English). 53: 6126-30. PMID 24821300 DOI: 10.1002/anie.201402750 |
0.64 |
|
| 2014 |
Filippakopoulos P, Knapp S. Targeting bromodomains: epigenetic readers of lysine acetylation. Nature Reviews. Drug Discovery. 13: 337-56. PMID 24751816 DOI: 10.1038/nrd4286 |
0.64 |
|
| 2014 |
Zhao Z, Wu H, Wang L, Liu Y, Knapp S, Liu Q, Gray NS. Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery? Acs Chemical Biology. 9: 1230-41. PMID 24730530 DOI: 10.1021/cb500129t |
0.64 |
|
| 2014 |
Brady DC, Crowe MS, Turski ML, Hobbs GA, Yao X, Chaikuad A, Knapp S, Xiao K, Campbell SL, Thiele DJ, Counter CM. Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature. 509: 492-6. PMID 24717435 DOI: 10.1038/nature13180 |
0.64 |
|
| 2014 |
Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, ... ... Knapp S, et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 508: 222-7. PMID 24695225 DOI: 10.1038/nature13194 |
0.64 |
|
| 2014 |
Cowan-Jacob SW, Jahnke W, Knapp S. Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases. Future Medicinal Chemistry. 6: 541-61. PMID 24649957 DOI: 10.4155/fmc.13.216 |
0.64 |
|
| 2014 |
Ekambaram R, Enkvist E, Manoharan Gb, Ugandi M, Kasari M, Viht K, Knapp S, Issinger OG, Uri A. Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases. Chemical Communications (Cambridge, England). 50: 4096-8. PMID 24619026 DOI: 10.1039/c3cc49198f |
0.64 |
|
| 2014 |
Ciceri P, Müller S, O'Mahony A, Fedorov O, Filippakopoulos P, Hunt JP, Lasater EA, Pallares G, Picaud S, Wells C, Martin S, Wodicka LM, Shah NP, Treiber DK, Knapp S. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nature Chemical Biology. 10: 305-12. PMID 24584101 DOI: 10.1038/nchembio.1471 |
0.64 |
|
| 2014 |
Liu S, Knapp S, Ahmed AA. The structural basis of PI3K cancer mutations: from mechanism to therapy. Cancer Research. 74: 641-6. PMID 24459181 DOI: 10.1158/0008-5472.CAN-13-2319 |
0.64 |
|
| 2014 |
Chaikuad A, Keates T, Vincke C, Kaufholz M, Zenn M, Zimmermann B, Gutiérrez C, Zhang RG, Hatzos-Skintges C, Joachimiak A, Muyldermans S, Herberg FW, Knapp S, Müller S. Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies. The Biochemical Journal. 459: 59-69. PMID 24438162 DOI: 10.1042/BJ20131399 |
0.64 |
|
| 2014 |
Chen C, Ha BH, Thévenin AF, Lou HJ, Zhang R, Yip KY, Peterson JR, Gerstein M, Kim PM, Filippakopoulos P, Knapp S, Boggon TJ, Turk BE. Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. Molecular Cell. 53: 140-7. PMID 24374310 DOI: 10.1016/j.molcel.2013.11.013 |
0.64 |
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| 2014 |
Selner NG, Luechapanichkul R, Chen X, Neel BG, Zhang ZY, Knapp S, Bell CE, Pei D. Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases. Biochemistry. 53: 397-412. PMID 24359314 DOI: 10.1021/bi401223r |
0.64 |
|
| 2014 |
Fedorov O, Lingard H, Wells C, Monteiro OP, Picaud S, Keates T, Yapp C, Philpott M, Martin SJ, Felletar I, Marsden BD, Filippakopoulos P, Müller S, Knapp S, Brennan PE. [1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains. Journal of Medicinal Chemistry. 57: 462-76. PMID 24313754 DOI: 10.1021/jm401568s |
0.64 |
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| 2014 |
van Ameijde J, Overvoorde J, Knapp S, den Hertog J, Ruijtenbeek R, Liskamp RM. A versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substrates. Analytical Biochemistry. 448: 9-13. PMID 24309020 DOI: 10.1016/j.ab.2013.11.023 |
0.64 |
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| 2014 |
Van Ameijde J, Overvoorde J, Knapp S, Den Hertog J, Ruijtenbeek R, Liskamp RM. A new way to interrogate PTPs Assay and Drug Development Technologies. 12: 105-106. DOI: 10.1089/adt.2014.1202.lr |
0.64 |
|
| 2014 |
Chaikuad A, Petros AM, Fedorov O, Xu J, Knapp S. Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain Medchemcomm. 5: 1843-1848. DOI: 10.1039/c4md00237g |
0.64 |
|
| 2014 |
Müller S, Knapp S. Discovery of BET bromodomain inhibitors and their role in target validation Medchemcomm. 5: 288-296. DOI: 10.1039/c3md00291h |
0.64 |
|
| 2014 |
Yang B, Sun Z, Liu C, Cui Y, Guo Z, Ren Y, Lu Z, Knapp S. O-(Aminosulfonylation) of phenols and an example of slow hydrolytic release Tetrahedron Letters. 55: 6658-6661. DOI: 10.1016/j.tetlet.2014.10.065 |
0.52 |
|
| 2014 |
Müller S, Lingard H, Knapp S. Selective Targeting of Protein Interactions Mediated by BET Bromodomains Concepts and Case Studies in Chemical Biology. 295-308. DOI: 10.1002/9783527687503.ch20 |
0.64 |
|
| 2014 |
Costa L, Casimiro S, Gupta S, Knapp S, Pillai MR, Toi M, Badwe R, Carmo-Fonseca M, Kumar R. The global cancer genomics consortium’s third annual symposium: From oncogenomics to cancer care Genes and Cancer. 5: 64-70. |
0.64 |
|
| 2013 |
Abdo M, Sun Z, Knapp S. Biohybrid -Se-S- coupling reactions of an amino acid derived seleninate. Molecules (Basel, Switzerland). 18: 1963-72. PMID 23381022 DOI: 10.3390/molecules18021963 |
0.52 |
|
| 2013 |
Won WS, Knapp S. β-D-Arabinosyl 1- C -sulfonic acid Journal of Sulfur Chemistry. 34: 33-37. DOI: 10.1080/17415993.2012.706814 |
0.52 |
|
| 2012 |
Abdo M, Knapp S. Mechanism of a redox coupling of seleninic acid with thiol. The Journal of Organic Chemistry. 77: 3433-8. PMID 22375858 DOI: 10.1021/jo300156x |
0.52 |
|
| 2010 |
Kim EJ, Love DC, Darout E, Abdo M, Rempel B, Withers SG, Rablen PR, Hanover JA, Knapp S. OGA inhibition by GlcNAc-selenazoline. Bioorganic & Medicinal Chemistry. 18: 7058-64. PMID 20822912 DOI: 10.1016/j.bmc.2010.08.010 |
0.52 |
|
| 2010 |
Abdo M, Zhang Y, Schramm VL, Knapp S. Electrophilic aromatic selenylation: new OPRT inhibitors. Organic Letters. 12: 2982-5. PMID 20521773 DOI: 10.1021/ol1010032 |
0.52 |
|
| 2010 |
Ajayi K, Thakur VV, Lapo RC, Knapp S. Intramolecular alpha-glucosaminidation: synthesis of mycothiol. Organic Letters. 12: 2630-3. PMID 20443569 DOI: 10.1021/ol1008334 |
0.36 |
|
| 2010 |
Macdonald JM, Tarling CA, Taylor EJ, Dennis RJ, Myers DS, Knapp S, Davies GJ, Withers SG. Chitinase inhibition by chitobiose and chitotriose thiazolines. Angewandte Chemie (International Ed. in English). 49: 2599-602. PMID 20209544 DOI: 10.1002/anie.200906644 |
0.52 |
|
| 2009 |
Knapp S, Fash D, Abdo M, Emge TJ, Rablen PR. GlcNAc-Thiazoline conformations. Bioorganic & Medicinal Chemistry. 17: 1831-6. PMID 19223181 DOI: 10.1016/j.bmc.2009.01.066 |
0.52 |
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| 2008 |
Abdo M, Liu S, Zhou B, Walls CD, Wu L, Knapp S, Zhang ZY. Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases. Journal of the American Chemical Society. 130: 13196-7. PMID 18781746 DOI: 10.1021/ja804489m |
0.52 |
|
| 2008 |
Slawson C, Lakshmanan T, Knapp S, Hart GW. A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin. Molecular Biology of the Cell. 19: 4130-40. PMID 18653473 DOI: 10.1091/mbc.E07-11-1146 |
0.52 |
|
| 2008 |
Abdo M, Knapp S. Biomimetic seleninates and selenonates. Journal of the American Chemical Society. 130: 9234-5. PMID 18576651 DOI: 10.1021/ja8034448 |
0.52 |
|
| 2008 |
Amorelli B, Yang C, Rempel B, Withers SG, Knapp S. N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines. Bioorganic & Medicinal Chemistry Letters. 18: 2944-7. PMID 18406613 DOI: 10.1016/j.bmcl.2008.03.067 |
0.52 |
|
| 2007 |
Knapp S, Ajayi K. The Anomeric Pudovik Rearrangement. Tetrahedron Letters. 48: 1945-1949. PMID 19617932 DOI: 10.1016/j.tetlet.2007.01.081 |
0.36 |
|
| 2007 |
Kim EJ, Amorelli B, Abdo M, Thomas CJ, Love DC, Knapp S, Hanover JA. Distinctive inhibition of O-GlcNAcase isoforms by an alpha-GlcNAc thiolsulfonate. Journal of the American Chemical Society. 129: 14854-5. PMID 17994748 DOI: 10.1021/ja076038u |
0.52 |
|
| 2007 |
Knapp S, Abdo M, Ajayi K, Huhn RA, Emge TJ, Kim EJ, Hanover JA. Tautomeric modification of GlcNAc-thiazoline. Organic Letters. 9: 2321-4. PMID 17508759 DOI: 10.1021/ol0706814 |
0.52 |
|
| 2007 |
Knapp S, Yu Y. Synthesis of the oxygenated pactamycin core. Organic Letters. 9: 1359-62. PMID 17338541 DOI: 10.1021/ol0702472 |
0.52 |
|
| 2006 |
Stibrany RT, Zhang C, Emge TJ, Schugar HJ, Potenza JA, Knapp S. A tris(pyrazolyl) eta6-arene ligand that selects Cu(I) over Cu(II). Inorganic Chemistry. 45: 9713-20. PMID 17112267 DOI: 10.1021/ic060980+ |
0.52 |
|
| 2006 |
Knapp S, Darout E, Amorelli B. New glycomimetics: anomeric sulfonates, sulfenamides, and sulfonamides. The Journal of Organic Chemistry. 71: 1380-9. PMID 16468785 DOI: 10.1021/jo0520386 |
0.52 |
|
| 2005 |
Knapp S, Yang C, Pabbaraja S, Rempel B, Reid S, Withers SG. Synthesis and kinetic analysis of the N-acetylhexosaminidase inhibitor XylNAc-isofagomine. The Journal of Organic Chemistry. 70: 7715-20. PMID 16149804 DOI: 10.1021/jo051117e |
0.44 |
|
| 2005 |
Knapp S, Darout E. New reactions of selenocarboxylates. Organic Letters. 7: 203-6. PMID 15646958 DOI: 10.1021/ol047889z |
0.52 |
|
| 2005 |
Knapp S, Amorelli B, Darout E, Ventocilla CC, Goldman LM, Huhn RA, Minnihan EC. A family of mycothiol analogues Journal of Carbohydrate Chemistry. 24: 103-130. DOI: 10.1081/CAR-200059965 |
0.52 |
|
| 2003 |
Zhang X, Fried A, Knapp S, Goldman AS. Novel synthesis of enamines by iridium-catalyzed dehydrogenation of tertiary amines. Chemical Communications (Cambridge, England). 2060-1. PMID 12934911 |
0.52 |
|
| 2002 |
Knapp S, Gonzalez S, Myers DS, Eckman LL, Bewley CA. Shortcut to mycothiol analogues. Organic Letters. 4: 4337-9. PMID 12443092 DOI: 10.1021/ol0269796 |
0.52 |
|
| 2002 |
Knapp S, Yang C, Haimowitz T. Addition of trialkylaluminum reagents to glyconolactones. Synthesis of 1-C-methyl GlcNAc oxazoline and thiazoline Tetrahedron Letters. 43: 7101-7104. DOI: 10.1016/S0040-4039(02)01506-X |
0.36 |
|
| 2002 |
Knapp S, Darout E. The surprise synthesis of α-GlcNAc 1-C-sulfonates Tetrahedron Letters. 43: 6075-6078. DOI: 10.1016/S0040-4039(02)01218-2 |
0.52 |
|
| 2001 |
Knapp S, Morriello GJ, Nandan SR, Emge TJ, Doss GA, Mosley RT, Chen L. Assignment of the liposidomycin diazepanone stereochemistry Journal of Organic Chemistry. 66: 5822-5831. PMID 11511258 DOI: 10.1021/jo010355g |
0.52 |
|
| 2000 |
Fox S, Stibrany RT, Potenza JA, Knapp S, Schugar HJ. Copper(II) and nickel(II) complexes of binucleating macrocyclic bis(disulfide)tetramine ligands. Inorganic Chemistry. 39: 4950-61. PMID 11196976 DOI: 10.1021/ic000380p |
0.52 |
|
| 2000 |
Knapp S, Gore VK. Synthesis of the ezomycin nucleoside disaccharide. Organic Letters. 2: 1391-3. PMID 10814455 DOI: 10.1021/ol005696f |
0.52 |
|
| 1999 |
Knapp S, Huang B, Emge TJ, Sheng S, Krogh-Jespersen K, Potenza JA, Schugar HJ. A pyropheophorbide dimer with single pyrrole π overlap and a low-energy Q absorption [24] Journal of the American Chemical Society. 121: 7977-7978. DOI: 10.1021/ja991632s |
0.52 |
|
| 1998 |
Knapp S, Vasudevan J, Emge TJ, Arison BH, Potenza JA, Schugar HJ. A Tethered Porphyrin Dimer with π Overlap of a Single Pyrrole Ring. Angewandte Chemie (International Ed. in English). 37: 2368-2370. PMID 29710963 DOI: 10.1002/(SICI)1521-3773(19980918)37:17<2368::AID-ANIE2368>3.0.CO;2-K |
0.4 |
|
| 1997 |
Chin T, Gao Z, Lelouche I, Shin YGK, Purandare A, Knapp S, Isied SS. Molecular recognition and reactivity of ruthenium(II) bipyridine barbituric acid guests in the presence of complementary hosts: Ruthenium(II) promoted enolization of barbituric acids in guest-host complexes Journal of the American Chemical Society. 119: 12849-12858. DOI: 10.1021/ja971481y |
0.52 |
|
| 1996 |
Knapp S, Gore VK. Synthesis of the Shimofuridin Nucleoside Disaccharide. The Journal of Organic Chemistry. 61: 6744-6747. PMID 11667554 DOI: 10.1021/jo960727z |
0.52 |
|
| 1996 |
Vasudevan J, Stibrany RT, Bumby J, Knapp S, Potenza JA, Emge TJ, Schugar HJ. An edge-over-edge Zn(II) bacteriochlorin dimer having an unshifted Q(y) band. The importance of π-overlap Journal of the American Chemical Society. 118: 11676-11677. DOI: 10.1021/ja9624376 |
0.52 |
|
| 1996 |
Stibrany RT, Vasudevan J, Knapp S, Potenza JA, Emge T, Schugar HJ. Two modes of self-coordinating edge-over-edge Zn(II) porphyrin dimerization: A structural and spectroscopic comparison Journal of the American Chemical Society. 118: 3980-3981. DOI: 10.1021/ja9536734 |
0.52 |
|
| 1995 |
Vepachedu S, Stibrany RT, Knapp S, Potenza JA, Schugar HJ. Tris(3,5-dimethylpyrazol-1-yl)methylsilane. Acta Crystallographica. Section C, Crystal Structure Communications. 51: 423-6. PMID 7734088 DOI: 10.1107/S0108270194007031 |
0.52 |
|
| 1990 |
Knapp S, Schreck RP, Carignan YP. A mechanistic study of the reaction of phenyl isocyanate with methyl 2,3,4-tri-O-acetyl-a-d-glucopyranoside Carbohydrate Research. 203: 290-295. PMID 2276125 DOI: 10.1016/0008-6215(90)80027-Z |
0.52 |
|
| 1990 |
Potenza JA, Kukkola PJ, Knapp S, Schugar HJ. Structures of a spiro[3.3]heptane and a related dispiro[3.1.3.1]decane derivtive Acta Crystallographica, Section C: Crystal Structure Communications. 46. PMID 2085417 DOI: 10.1107/S0108270190002967 |
0.52 |
|
| 1986 |
Knapp S, Sebastian MJ, Ramanathan H, Bharadwaj P, Potenza JA. Synthesis of (-)-fortamine and (+)-2-deoxyfortamine from resolved 3S,4S-N-carbomethoxy-3-aminocyclohexen-4-ol Tetrahedron. 42: 3405-3410. DOI: 10.1016/S0040-4020(01)87307-5 |
0.52 |
|
| 1984 |
Knapp S, Trope AF, Theodore MS, Hirata N, Barchi JJ. Ring expansion of ketones to 1,2-keto thioketals. Control of bond migration Journal of Organic Chemistry. 49: 608-614. |
0.52 |
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