Jun O. Liu - Publications

Affiliations: 
Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine, Baltimore, MD, United States 
Website:
http://www.hopkinsmedicine.org/profiles/results/directory/profile/0800038/jun-liu

185 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Guo Z, Hong SY, Wang J, Rehan S, Liu W, Peng H, Das M, Li W, Bhat S, Peiffer B, Ullman BR, Tse CM, Tarmakova Z, Schiene-Fischer C, Fischer G, ... Liu JO, et al. Rapamycin-inspired macrocycles with new target specificity. Nature Chemistry. PMID 30532015 DOI: 10.1038/s41557-018-0187-4  1
2018 Li Y, Pasunooti KK, Li RJ, Liu W, Head SA, Shi WQ, Liu JO. Novel Tetrazole-containing Analogs of Itraconazole as Potent Anti-angiogenic Agents with Reduced CYP3A4 Inhibition. Journal of Medicinal Chemistry. PMID 30481027 DOI: 10.1021/acs.jmedchem.8b01252  1
2018 Lyu J, Yang EJ, Head SA, Ai N, Zhang B, Wu C, Li RJ, Liu Y, Chakravarty H, Zhang S, Tam KY, Dang Y, Kwon HJ, Ge W, Liu JO, et al. Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking. International Journal of Biological Sciences. 14: 1175-1185. PMID 30123067 DOI: 10.7150/ijbs.26011  1
2018 Bauer L, Ferla S, Head SA, Bhat S, Pasunooti KK, Shi WQ, Albulescu L, Liu JO, Brancale A, van Kuppeveld FJM, Strating JRPM. Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP). Antiviral Research. PMID 29807040 DOI: 10.1016/j.antiviral.2018.05.010  1
2018 Jiang W, Zhou X, Li Z, Liu K, Wang W, Tan R, Cong X, Shan J, Zhan Y, Cui Z, Jiang L, Li Q, Shen S, Bai M, Cheng Y, ... ... Liu JO, et al. Prolyl 4-Hydroxylase 2 Promotes B-cell Lymphoma Progression via Hydroxylation of Carabin. Blood. PMID 29437589 DOI: 10.1182/blood-2017-07-794875  1
2017 Li Z, Cheng Z, Raghothama C, Cui Z, Liu K, Li X, Jiang C, Jiang W, Tan M, Ni X, Pandey A, Liu JO, Dang Y. USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1. Nucleic Acids Research. PMID 29228324 DOI: 10.1093/nar/gkx1226  1
2017 Lyu J, Yang EJ, Head SA, Ai N, Zhang B, Wu C, Li RJ, Liu Y, Yang C, Dang Y, Kwon HJ, Ge W, Liu JO, Shim JS. Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth. Cancer Letters. PMID 28923401 DOI: 10.1016/j.canlet.2017.09.009  1
2017 McClary B, Zinshteyn B, Meyer M, Jouanneau M, Pellegrino S, Yusupova G, Schuller A, Reyes JCP, Lu J, Guo Z, Ayinde S, Luo C, Dang Y, Romo D, Yusupov M, ... ... Liu JO, et al. Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. Cell Chemical Biology. PMID 28457705 DOI: 10.1016/j.chembiol.2017.04.006  1
2017 Head SA, Shi WQ, Yang EJ, Nacev BA, Hong SY, Pasunooti KK, Li RJ, Shim JS, Liu JO. Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis. Acs Chemical Biology. 12: 174-182. PMID 28103683 DOI: 10.1021/acschembio.6b00849  1
2016 John SF, Aniemeke E, Ha NP, Chong CR, Gu P, Zhou J, Zhang Y, Graviss EA, Liu JO, Olaleye OA. Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). PMID 27856197 DOI: 10.1016/j.tube.2016.09.025  1
2016 Li RJ, Xu J, Fu C, Zhang J, Zheng YG, Jia H, Liu JO. Regulation of mTORC1 by lysosomal calcium and calmodulin. Elife. 5. PMID 27787197 DOI: 10.7554/eLife.19360  1
2016 Wang X, Maruvada R, Morris AJ, Liu JO, Wolfgang MJ, Baek DJ, Bittman R, Kim KS. Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. Plos Pathogens. 12: e1005926. PMID 27711202 DOI: 10.1371/journal.ppat.1005926  1
2016 Cho YS, Yen CN, Shim JS, Kang DH, Kang SW, Liu JO, Kwon HJ. Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway. Scientific Reports. 6: 34655. PMID 27694974 DOI: 10.1038/srep34655  0.84
2016 Head SA, Liu JO. Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling. Journal of Visualized Experiments : Jove. PMID 27684515 DOI: 10.3791/54529  1
2016 Qiu H, Qian S, Head SA, Liu JO, Jin Z. Insights into the structure-activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A role played by the lactone moiety. Bioorganic & Medicinal Chemistry Letters. PMID 27595422 DOI: 10.1016/j.bmcl.2016.08.046  0.8
2016 He QL, Minn I, Wang Q, Xu P, Head SA, Datan E, Yu B, Pomper MG, Liu JO. Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation. Angewandte Chemie (International Ed. in English). PMID 27574181 DOI: 10.1002/anie.201606121  1
2016 Qian S, Shah AK, Head SA, Liu JO, Jin Z. Insights into the structure-activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A critical role played by the conjugated trienyl lactone moiety. Bioorganic & Medicinal Chemistry Letters. PMID 27374243 DOI: 10.1016/j.bmcl.2016.06.057  0.8
2016 Shah AK, Qian S, Zhang D, Head SA, Liu JO, Jin Z. Insights into the structure-activity relationship of the anticancer compound ZJ-101: A critical role played by the cyclohexene ring. Bioorganic & Medicinal Chemistry Letters. PMID 27133592 DOI: 10.1016/j.bmcl.2016.04.044  0.56
2016 Romo D, Liu JO. Editorial: Strategies for cellular target identification of natural products. Natural Product Reports. PMID 27118358 DOI: 10.1039/c6np90016j  1
2016 Jouanneau M, McClary B, Reyes JC, Chen R, Chen Y, Plunkett W, Cheng X, Milinichik AZ, Albone EF, Liu JO, Romo D. Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe. Bioorganic & Medicinal Chemistry Letters. PMID 26951751 DOI: 10.1016/j.bmcl.2016.02.051  0.84
2016 Shim JS, Li RJ, Bumpus N, Head S, Pasunooti K, Yang EJ, Lv J, Shi W, Liu JO. Divergence of Anti-angiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26801248 DOI: 10.1158/1078-0432.CCR-15-1888  1
2016 Fox JM, Moynihan JR, Mott BT, Mazzone JR, Anders NM, Brown PA, Rudek MA, Liu JO, Arav-Boger R, Posner GH, Civin CI, Chen X. Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs. Oncotarget. PMID 26771236 DOI: 10.18632/oncotarget.6896  0.48
2015 Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T, Zhang J, Zhao Y, Colombini M, Liu JO. Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26655341 DOI: 10.1073/pnas.1512867112  0.76
2015 Lu J, Jiang C, Li X, Jiang L, Li Z, Schneider-Poetsch T, Liu J, Yu K, Liu JO, Jiang H, Luo C, Dang Y. A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation. Nucleic Acids Research. PMID 26464436 DOI: 10.1093/nar/gkv1033  1
2015 Lee HG, Kim H, Kim EJ, Park PG, Dong SM, Choi TH, Kim H, Chong CR, Liu JO, Chen J, Ambinder RF, Hayward SD, Park JH, Lee JM. Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation. Oncotarget. PMID 26427042 DOI: 10.18632/oncotarget.5041  1
2015 Wang G, Rajpurohit SK, Delaspre F, Walker SL, White DT, Ceasrine A, Kuruvilla R, Li RJ, Shim JS, Liu JO, Parsons MJ, Mumm JS. First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass. Elife. 4. PMID 26218223 DOI: 10.7554/eLife.08261  1
2015 He R, Yu ZH, Zhang RY, Wu L, Gunawan AM, Lane BS, Shim JS, Zeng LF, He Y, Chen L, Wells CD, Liu JO, Zhang ZY. Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. Acs Medicinal Chemistry Letters. 6: 782-6. PMID 26191366 DOI: 10.1021/acsmedchemlett.5b00118  1
2015 Jiang DK, Ma XP, Yu H, Cao G, Ding DL, Chen H, Huang HX, Gao YZ, Wu XP, Long XD, Zhang H, Zhang Y, Gao Y, Chen TY, Ren WH, ... ... Liu JO, et al. Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. Hepatology (Baltimore, Md.). 62: 118-28. PMID 25802187 DOI: 10.1002/hep.27794  1
2015 Shim JS, Li RJ, Lv J, Head SA, Yang EJ, Liu JO. Inhibition of angiogenesis by selective estrogen receptor modulators through blockade of cholesterol trafficking rather than estrogen receptor antagonism. Cancer Letters. 362: 106-15. PMID 25799952 DOI: 10.1016/j.canlet.2015.03.022  1
2015 Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, ... ... Liu JO, et al. Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Reports. 10: 600-15. PMID 25640182 DOI: 10.1016/j.celrep.2014.12.054  1
2015 Saiyin H, Ardito-Abraham CM, Wu Y, Wei Y, Fang Y, Han X, Li J, Zhou P, Yi Q, Maitra A, Liu JO, Tuveson DA, Lou W, Yu L. Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma. The Journal of Pathology. 236: 142-54. PMID 25561062 DOI: 10.1002/path.4506  1
2015 He QL, Titov DV, Li J, Tan M, Ye Z, Zhao Y, Romo D, Liu JO. Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide. Angewandte Chemie (International Ed. in English). 54: 1859-63. PMID 25504624 DOI: 10.1002/anie.201408817  1
2015 Wang G, Rajpurohit SK, Delaspre F, Walker SL, White DT, Ceasrine A, Kuruvilla R, Li RJ, Shim JS, Liu JO, Parsons MJ, Mumm JS. First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass Elife. 4. DOI: 10.7554/eLife.08261.001  1
2014 Jiang W, Huang H, Ding L, Zhu P, Saiyin H, Ji G, Zuo J, Han D, Pan Y, Ding D, Ma X, Zhang Y, Wu J, Yi Q, Liu JO, et al. Regulation of cell cycle of hepatocellular carcinoma by NF90 through modulation of cyclin E1 mRNA stability. Oncogene. PMID 25399696 DOI: 10.1038/onc.2014.373  1
2014 Somnath S, Liu JO, Bakir M, Prater CB, King WP. Multifunctional atomic force microscope cantilevers with Lorentz force actuation and self-heating capability. Nanotechnology. 25: 395501. PMID 25189800 DOI: 10.1088/0957-4484/25/39/395501  0.36
2014 Shim JS, Liu JO. Recent advances in drug repositioning for the discovery of new anticancer drugs. International Journal of Biological Sciences. 10: 654-63. PMID 25013375 DOI: 10.7150/ijbs.9224  1
2014 Wang M, Shim JS, Li RJ, Dang Y, He Q, Das M, Liu JO. Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer. British Journal of Pharmacology. 171: 4478-89. PMID 24903412 DOI: 10.1111/bph.12800  1
2014 Wissing MD, Dadon T, Kim E, Piontek KB, Shim JS, Kaelber NS, Liu JO, Kachhap SK, Nelkin BD. Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression. Oncology Reports. 32: 419-24. PMID 24841903 DOI: 10.3892/or.2014.3174  1
2014 Lin Q, Wesson RN, Maeda H, Wang Y, Cui Z, Liu JO, Cameron AM, Gao B, Montgomery RA, Williams GM, Sun Z. Pharmacological mobilization of endogenous stem cells significantly promotes skin regeneration after full-thickness excision: the synergistic activity of AMD3100 and tacrolimus. The Journal of Investigative Dermatology. 134: 2458-68. PMID 24682043 DOI: 10.1038/jid.2014.162  1
2014 Low WK, Li J, Zhu M, Kommaraju SS, Shah-Mittal J, Hull K, Liu JO, Romo D. Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents. Bioorganic & Medicinal Chemistry. 22: 116-25. PMID 24359706 DOI: 10.1016/j.bmc.2013.11.046  1
2013 Kishor C, Arya T, Reddi R, Chen X, Saddanapu V, Marapaka AK, Gumpena R, Ma D, Liu JO, Addlagatta A. Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases. Journal of Medicinal Chemistry. 56: 5295-305. PMID 23767698 DOI: 10.1021/jm400395p  1
2013 Liu C, Ma H, Wu J, Huang Q, Liu JO, Yu L. Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins. Bmc Cell Biology. 14: 27. PMID 23721406 DOI: 10.1186/1471-2121-14-27  1
2013 Kong X, Peng B, Yang Y, Zhang P, Qin B, Han D, Wang C, Dang Y, Liu JO, Yu L. p53 Represses transcription of RING finger LIM domain-binding protein RLIM through Sp1. Plos One. 8: e62832. PMID 23650532 DOI: 10.1371/journal.pone.0062832  1
2013 Zhang F, Bhat S, Gabelli SB, Chen X, Miller MS, Nacev BA, Cheng YL, Meyers DJ, Tenney K, Shim JS, Crews P, Amzel LM, Ma D, Liu JO. Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells Journal of Medicinal Chemistry. 56: 3996-4016. PMID 23634668 DOI: 10.1021/jm400227z  1
2013 Fatokun AA, Liu JO, Dawson VL, Dawson TM. Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos. British Journal of Pharmacology. 169: 1263-78. PMID 23550801 DOI: 10.1111/bph.12201  1
2013 Rudin CM, Brahmer JR, Juergens RA, Hann CL, Ettinger DS, Sebree R, Smith R, Aftab BT, Huang P, Liu JO. Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 8: 619-23. PMID 23546045 DOI: 10.1097/JTO.0b013e31828c3950  1
2013 Bhat S, Shim JS, Liu JO. Tricyclic thiazoles are a new class of angiogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 2733-7. PMID 23518276 DOI: 10.1016/j.bmcl.2013.02.067  1
2013 Zhang P, Yang X, Zhang F, Gabelli SB, Wang R, Zhang Y, Bhat S, Chen X, Furlani M, Amzel LM, Liu JO, Ma D. Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorganic & Medicinal Chemistry. 21: 2600-17. PMID 23507151 DOI: 10.1016/j.bmc.2013.02.023  1
2013 Wissing MD, Mendonca J, Kim E, Kim E, Shim JS, Kaelber NS, Kant H, Hammers H, Commes T, Van Diest PJ, Liu JO, Kachhap SK. Identification of cetrimonium bromide and irinotecan as compounds with synthetic lethality against NDRG1 deficient prostate cancer cells. Cancer Biology & Therapy. 14: 401-10. PMID 23377825 DOI: 10.4161/cbt.23759  1
2013 Kamiyama H, Rauenzahn S, Shim JS, Karikari CA, Feldmann G, Hua L, Kamiyama M, Schuler FW, Lin MT, Beaty RM, Karanam B, Liang H, Mullendore ME, Mo G, Hidalgo M, ... ... Liu JO, et al. Personalized chemotherapy profiling using cancer cell lines from selectable mice. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 1139-46. PMID 23340293 DOI: 10.1158/1078-0432.CCR-12-2127  1
2013 Choi SM, Kim Y, Shim JS, Park JT, Wang RH, Leach SD, Liu JO, Deng C, Ye Z, Jang YY. Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology (Baltimore, Md.). 57: 2458-68. PMID 23325555 DOI: 10.1002/hep.26237  1
2013 Yang Y, Wang C, Zhang P, Gao K, Wang D, Yu H, Zhang T, Jiang S, Hexige S, Hong Z, Yasui A, Liu JO, Huang H, Yu L. Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis. The Journal of Biological Chemistry. 288: 529-39. PMID 23150668 DOI: 10.1074/jbc.M111.338996  1
2013 Kurata S, Shen B, Liu JO, Takeuchi N, Kaji A, Kaji H. Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors. Nucleic Acids Research. 41: 264-76. PMID 23087377 DOI: 10.1093/nar/gks958  1
2013 Liu JO, Somnath S, King WP. Heated atomic force microscope cantilever with high resistivity for improved temperature sensitivity Sensors and Actuators, a: Physical. 201: 141-147. DOI: 10.1016/j.sna.2013.07.010  0.36
2012 Shim JS, Rao R, Beebe K, Neckers L, Han I, Nahta R, Liu JO. Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir. Journal of the National Cancer Institute. 104: 1576-90. PMID 23042933 DOI: 10.1093/jnci/djs396  1
2012 Chen XY, Gu XT, Saiyin H, Wan B, Zhang YJ, Li J, Wang YL, Gao R, Wang YF, Dong WP, Najjar SM, Zhang CY, Ding HF, Liu JO, Yu L. Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells. The Journal of Biological Chemistry. 287: 30368-75. PMID 22798068 DOI: 10.1074/jbc.M112.375618  1
2012 Krátký M, Vinšová J, Novotná E, Mandíková J, Wsól V, Trejtnar F, Ulmann V, Stolaříková J, Fernandes S, Bhat S, Liu JO. Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase. Tuberculosis (Edinburgh, Scotland). 92: 434-9. PMID 22765970 DOI: 10.1016/j.tube.2012.06.001  1
2012 Bhat S, Olaleye O, Meyer KJ, Shi W, Zhang Y, Liu JO. Analogs of N'-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases. Bioorganic & Medicinal Chemistry. 20: 4507-13. PMID 22704656 DOI: 10.1016/j.bmc.2012.05.022  1
2012 Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee SJ, Anders RA, Liu JO, Pan D. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes & Development. 26: 1300-5. PMID 22677547 DOI: 10.1101/gad.192856.112  1
2012 Bhat S, Shim JS, Zhang F, Chong CR, Liu JO. Substituted oxines inhibit endothelial cell proliferation and angiogenesis. Organic & Biomolecular Chemistry. 10: 2979-92. PMID 22391578 DOI: 10.1039/c2ob06978d  1
2012 Wang C, An J, Zhang P, Xu C, Gao K, Wu D, Wang D, Yu H, Liu JO, Yu L. The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation. The Biochemical Journal. 444: 279-89. PMID 22385262 DOI: 10.1042/BJ20111983  1
2012 Titov DV, Liu JO. Identification and validation of protein targets of bioactive small molecules. Bioorganic & Medicinal Chemistry. 20: 1902-9. PMID 22226983 DOI: 10.1016/j.bmc.2011.11.070  1
2012 Xing S, Bhat S, Shroff NS, Zhang H, Lopez JA, Margolick JB, Liu JO, Siliciano RF. Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation. The Journal of Antimicrobial Chemotherapy. 67: 398-403. PMID 22160146 DOI: 10.1093/jac/dkr496  1
2012 Peng CC, Shi W, Lutz JD, Kunze KL, Liu JO, Nelson WL, Isoherranen N. Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 426-35. PMID 22106171 DOI: 10.1124/dmd.111.042739  1
2011 Platz EA, Yegnasubramanian S, Liu JO, Chong CR, Shim JS, Kenfield SA, Stampfer MJ, Willett WC, Giovannucci E, Nelson WG. A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment. Cancer Discovery. 1: 68-77. PMID 22140654 DOI: 10.1158/2159-8274.CD-10-0020  1
2011 Olaleye O, Raghunand TR, Bhat S, Chong C, Gu P, Zhou J, Zhang Y, Bishai WR, Liu JO. Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 91: S61-5. PMID 22115541 DOI: 10.1016/j.tube.2011.10.012  1
2011 Rovira M, Huang W, Yusuff S, Shim JS, Ferrante AA, Liu JO, Parsons MJ. Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation. Proceedings of the National Academy of Sciences of the United States of America. 108: 19264-9. PMID 22084084 DOI: 10.1073/pnas.1113081108  1
2011 Nacev BA, Grassi P, Dell A, Haslam SM, Liu JO. The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. The Journal of Biological Chemistry. 286: 44045-56. PMID 22025615 DOI: 10.1074/jbc.M111.278754  1
2011 Nacev BA, Liu JO. Synergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazole. Plos One. 6: e24793. PMID 21969860 DOI: 10.1371/journal.pone.0024793  1
2011 Shi W, Nacev BA, Aftab BT, Head S, Rudin CM, Liu JO. Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling. Journal of Medicinal Chemistry. 54: 7363-74. PMID 21936514 DOI: 10.1021/jm200944b  1
2011 Aftab BT, Dobromilskaya I, Liu JO, Rudin CM. Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer. Cancer Research. 71: 6764-72. PMID 21896639 DOI: 10.1158/0008-5472.CAN-11-0691  1
2011 Chamni S, He QL, Dang Y, Bhat S, Liu JO, Romo D. Diazo reagents with small steric footprints for simultaneous arming/SAR studies of alcohol-containing natural products via O-H insertion. Acs Chemical Biology. 6: 1175-81. PMID 21894934 DOI: 10.1021/cb2002686  1
2011 Li W, Bhat S, Liu JO. A simple and efficient route to the FKBP-binding domain from rapamycin. Tetrahedron Letters. 52: 5070-5072. PMID 21894238 DOI: 10.1016/j.tetlet.2011.07.094  1
2011 Dang Y, Schneider-Poetsch T, Eyler DE, Jewett JC, Bhat S, Rawal VH, Green R, Liu JO. Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B. Rna (New York, N.Y.). 17: 1578-88. PMID 21693620 DOI: 10.1261/rna.2624511  1
2011 Nacev BA, Low WK, Huang Z, Su TT, Su Z, Alkuraya H, Kasuga D, Sun W, Träger M, Braun M, Fischer G, Zhang K, Liu JO. A calcineurin-independent mechanism of angiogenesis inhibition by a nonimmunosuppressive cyclosporin A analog. The Journal of Pharmacology and Experimental Therapeutics. 338: 466-75. PMID 21562139 DOI: 10.1124/jpet.111.180851  1
2011 Wilson BA, Wang H, Nacev BA, Mease RC, Liu JO, Pomper MG, Isaacs WB. High-throughput screen identifies novel inhibitors of cancer biomarker α-methylacyl coenzyme A racemase (AMACR/P504S). Molecular Cancer Therapeutics. 10: 825-38. PMID 21441411 DOI: 10.1158/1535-7163.MCT-10-0902  1
2011 Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, Goodrich JA, Liu JO. XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nature Chemical Biology. 7: 182-8. PMID 21278739 DOI: 10.1038/nchembio.522  1
2011 He J, Ye J, Cai Y, Riquelme C, Liu JO, Liu X, Han A, Chen L. Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly. Nucleic Acids Research. 39: 4464-74. PMID 21278418 DOI: 10.1093/nar/gkr030  1
2011 Liu JO, Titov DV, Dang Y, He Q. Regulator of Ras depalmitoylation and retrograde trafficking: a new hat for FKBP. Molecular Cell. 41: 131-3. PMID 21255722 DOI: 10.1016/j.molcel.2011.01.009  1
2011 Lin J, Haffner MC, Zhang Y, Lee BH, Brennen WN, Britton J, Kachhap SK, Shim JS, Liu JO, Nelson WG, Yegnasubramanian S, Carducci MA. Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth. The Prostate. 71: 333-43. PMID 20809552 DOI: 10.1002/pros.21247  1
2010 Shi W, Nacev BA, Bhat S, Liu JO. Impact of Absolute Stereochemistry on the Antiangiogenic and Antifungal Activities of Itraconazole. Acs Medicinal Chemistry Letters. 1: 155-159. PMID 21892383 DOI: 10.1021/ml1000068  1
2010 Shim JS, Matsui Y, Bhat S, Nacev BA, Xu J, Bhang HE, Dhara S, Han KC, Chong CR, Pomper MG, So A, Liu JO. Effect of nitroxoline on angiogenesis and growth of human bladder cancer. Journal of the National Cancer Institute. 102: 1855-73. PMID 21088277 DOI: 10.1093/jnci/djq457  1
2010 Zhu P, Jiang W, Cao L, Yu W, Pei Y, Yang X, Wan B, Liu JO, Yi Q, Yu L. IL-2 mRNA stabilization upon PMA stimulation is dependent on NF90-Ser647 phosphorylation by protein kinase CbetaI. Journal of Immunology (Baltimore, Md. : 1950). 185: 5140-9. PMID 20870937 DOI: 10.4049/jimmunol.1000849  1
2010 Huang W, Ding L, Huang Q, Hu H, Liu S, Yang X, Hu X, Dang Y, Shen S, Li J, Ji X, Jiang S, Liu JO, Yu L. Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma. Hepatology (Baltimore, Md.). 52: 703-14. PMID 20683966 DOI: 10.1002/hep.23723  1
2010 Xiao Q, Zhang F, Nacev BA, Liu JO, Pei D. Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. Biochemistry. 49: 5588-99. PMID 20521764 DOI: 10.1021/bi1005464  1
2010 Li W, Dang Y, Liu JO, Yu B. Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity. Bioorganic & Medicinal Chemistry Letters. 20: 3112-5. PMID 20409710 DOI: 10.1016/j.bmcl.2010.03.093  1
2010 Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner D, Reya T, Liu JO, Epstein EH, Stevens DA, Beachy PA. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 17: 388-99. PMID 20385363 DOI: 10.1016/j.ccr.2010.02.027  1
2010 Xu J, Dang Y, Ren YR, Liu JO. Cholesterol trafficking is required for mTOR activation in endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 4764-9. PMID 20176935 DOI: 10.1073/pnas.0910872107  1
2010 Olaleye O, Raghunand TR, Bhat S, He J, Tyagi S, Lamichhane G, Gu P, Zhou J, Zhang Y, Grosset J, Bishai WR, Liu JO. Methionine aminopeptidases from Mycobacterium tuberculosis as novel antimycobacterial targets. Chemistry & Biology. 17: 86-97. PMID 20142044 DOI: 10.1016/j.chembiol.2009.12.014  1
2010 Schneider-Poetsch T, Ju J, Eyler DE, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nature Chemical Biology. 6: 209-217. PMID 20118940 DOI: 10.1038/nchembio.304  1
2010 Zhang P, Wang C, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L. The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. The Journal of Biological Chemistry. 285: 8869-79. PMID 20068034 DOI: 10.1074/jbc.M109.063321  1
2010 Schneider-Poetsch T, Ju J, Eyler DE, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin Nature Chemical Biology. 6: 209-217. DOI: 10.1038/nchembio.304  1
2010 Zha XM, Zhang FR, Shan JQ, Zhang YH, Liu JO, Sun HB. Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives Chinese Chemical Letters. 21: 1087-1090. DOI: 10.1016/j.cclet.2010.04.020  1
2009 Olaleye OA, Bishai WR, Liu JO. Targeting the role of N-terminal methionine processing enzymes in Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 89: S55-9. PMID 20006307 DOI: 10.1016/S1472-9792(09)70013-7  1
2009 Yang HC, Xing S, Shan L, O'Connell K, Dinoso J, Shen A, Zhou Y, Shrum CK, Han Y, Liu JO, Zhang H, Margolick JB, Siliciano RF. Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. The Journal of Clinical Investigation. 119: 3473-86. PMID 19805909 DOI: 10.1172/JCI39199  1
2009 Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proceedings of the National Academy of Sciences of the United States of America. 106: 17910-5. PMID 19805192 DOI: 10.1073/pnas.0909353106  1
2009 Li W, Dang Y, Liu JO, Yu B. Expeditious synthesis of hippuristanol and congeners with potent antiproliferative activities. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 10356-9. PMID 19746484 DOI: 10.1002/chem.200901732  1
2009 Pan F, Yu H, Dang EV, Barbi J, Pan X, Grosso JF, Jinasena D, Sharma SM, McCadden EM, Getnet D, Drake CG, Liu JO, Ostrowski MC, Pardoll DM. Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (New York, N.Y.). 325: 1142-6. PMID 19696312 DOI: 10.1126/science.1176077  1
2009 Woodard LE, Chang W, Chen X, Liu JO, Shapiro TA, Posner GH. Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose Journal of Medicinal Chemistry. 52: 7458-7462. PMID 19586052 DOI: 10.1021/jm9005934  1
2009 Dang Y, Low WK, Xu J, Gehring NH, Dietz HC, Romo D, Liu JO. Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. The Journal of Biological Chemistry. 284: 23613-21. PMID 19570977 DOI: 10.1074/jbc.M109.009985  1
2009 Zhang Y, Byun Y, Ren YR, Liu JO, Laterra J, Pomper MG. Identification of inhibitors of ABCG2 by a bioluminescence imaging-based high-throughput assay Cancer Research. 69: 5867-5875. PMID 19567678 DOI: 10.1158/0008-5472.CAN-08-4866  1
2009 Liu JO, Nacev BA, Xu J, Bhat S. It takes two binding sites for calcineurin and NFAT to tango. Molecular Cell. 33: 676-8. PMID 19328062 DOI: 10.1016/j.molcel.2009.03.005  1
2009 Liu JO. Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation. Immunological Reviews. 228: 184-98. PMID 19290928 DOI: 10.1111/j.1600-065X.2008.00756.x  1
2009 Chen X, Xie S, Bhat S, Kumar N, Shapiro TA, Liu JO. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chemistry & Biology. 16: 193-202. PMID 19246010 DOI: 10.1016/j.chembiol.2009.01.006  1
2009 Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH. Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. Journal of Medicinal Chemistry. 52: 1198-203. PMID 19186946 DOI: 10.1021/jm801484v  1
2009 Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 2353-8. PMID 19168635 DOI: 10.1073/pnas.0812801106  1
2008 Ren YR, Pan F, Parvez S, Fleig A, Chong CR, Xu J, Dang Y, Zhang J, Jiang H, Penner R, Liu JO. Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. Plos One. 3: e4009. PMID 19104661 DOI: 10.1371/journal.pone.0004009  1
2008 Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL. Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth Proceedings of the National Academy of Sciences of the United States of America. 105: 19579-19586. PMID 19020076 DOI: 10.1073/pnas.0809763105  1
2008 McMahon MA, Siliciano JD, Lai J, Liu JO, Stivers JT, Siliciano RF, Kohli RM. The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation. The Journal of Biological Chemistry. 283: 31289-93. PMID 18818198 DOI: 10.1074/jbc.C800188200  1
2008 Wang Y, Zhang F, Zhang Y, Liu JO, Ma D. Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues. Bioorganic & Medicinal Chemistry Letters. 18: 4385-7. PMID 18606540 DOI: 10.1016/j.bmcl.2008.06.066  1
2008 Pei Y, Zhu P, Dang Y, Wu J, Yang X, Wan B, Liu JO, Yi Q, Yu L. Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation. Journal of Immunology (Baltimore, Md. : 1950). 180: 222-9. PMID 18097023  1
2008 Galbán S, Kuwano Y, Pullmann R, Martindale JL, Kim HH, Lal A, Abdelmohsen K, Yang X, Dang Y, Liu JO, Lewis SM, Holcik M, Gorospe M. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Molecular and Cellular Biology. 28: 93-107. PMID 17967866 DOI: 10.1128/MCB.00973-07  1
2007 Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. The Journal of Biological Chemistry. 282: 37064-73. PMID 17965024 DOI: 10.1074/jbc.M705015200  1
2007 Hu XV, Chen X, Han KC, Mildvan AS, Liu JO. Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases. Biochemistry. 46: 12833-43. PMID 17929833 DOI: 10.1021/bi701127x  1
2007 Low WK, Dang Y, Schneider-Poetsch T, Shi Z, Choi NS, Rzasa RM, Shea HA, Li S, Park K, Ma G, Romo D, Liu JO. Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A. Methods in Enzymology. 431: 303-24. PMID 17923240 DOI: 10.1016/S0076-6879(07)31014-8  1
2007 Peddibhotla S, Dang Y, Liu JO, Romo D. Simultaneous arming and structure/activity studies of natural products employing O-H insertions: an expedient and versatile strategy for natural products-based chemical genetics. Journal of the American Chemical Society. 129: 12222-31. PMID 17880073 DOI: 10.1021/ja0733686  1
2007 Byrne ST, Gu P, Zhou J, Denkin SM, Chong C, Sullivan D, Liu JO, Zhang Y. Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 51: 4495-7. PMID 17876006 DOI: 10.1128/AAC.00753-07  1
2007 Peng W, Tang P, Hu X, Liu JO, Yu B. Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities. Bioorganic & Medicinal Chemistry Letters. 17: 5506-9. PMID 17826089 DOI: 10.1016/j.bmcl.2007.08.060  1
2007 Hu X, Dang Y, Tenney K, Crews P, Tsai CW, Sixt KM, Cole PA, Liu JO. Regulation of c-Src Nonreceptor Tyrosine Kinase Activity by Bengamide A through Inhibition of Methionine Aminopeptidases Chemistry and Biology. 14: 764-774. PMID 17656313 DOI: 10.1016/j.chembiol.2007.05.010  1
2007 Low WK, Dang Y, Bhat S, Romo D, Liu JO. Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity. Chemistry & Biology. 14: 715-27. PMID 17584618 DOI: 10.1016/j.chembiol.2007.05.012  1
2007 McMahon MA, Jilek BL, Brennan TP, Shen L, Zhou Y, Wind-Rotolo M, Xing S, Bhat S, Hale B, Hegarty R, Chong CR, Liu JO, Siliciano RF, Thio CL. The HBV drug entecavir - effects on HIV-1 replication and resistance. The New England Journal of Medicine. 356: 2614-21. PMID 17582071 DOI: 10.1056/NEJMoa067710  1
2007 Chong CR, Xu J, Lu J, Bhat S, Sullivan DJ, Liu JO. Inhibition of angiogenesis by the antifungal drug itraconazole. Acs Chemical Biology. 2: 263-70. PMID 17432820 DOI: 10.1021/cb600362d  1
2007 Pan F, Sun L, Kardian DB, Whartenby KA, Pardoll DM, Liu JO. Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. Nature. 445: 433-6. PMID 17230191 DOI: 10.1038/nature05476  1
2007 Tang P, Mamdani F, Hu X, Liu JO, Yu B. Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities. Bioorganic & Medicinal Chemistry Letters. 17: 1003-7. PMID 17127060 DOI: 10.1016/j.bmcl.2006.11.032  1
2007 Liu JO, Simon JA. Use of yeast as a model system for identifying and studying anticancer drugs Yeast as a Tool in Cancer Research. 375-391. DOI: 10.1007/978-1-4020-5963-6_14  1
2006 Allen MD, DiPilato LM, Rahdar M, Ren YR, Chong C, Liu JO, Zhang J. Reading dynamic kinase activity in living cells for high-throughput screening. Acs Chemical Biology. 1: 371-6. PMID 17163774 DOI: 10.1021/cb600202f  1
2006 Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proceedings of the National Academy of Sciences of the United States of America. 103: 18148-53. PMID 17114291 DOI: 10.1073/pnas.0608389103  1
2006 Zhou M, Sivaramakrishnan A, Ponnamperuma K, Low WK, Li C, Liu JO, Bergbreiter DE, Romo D. Synthesis, characterization, and utility of thermoresponsive natural/unnatural product macroligands for affinity chromatography. Organic Letters. 8: 5247-50. PMID 17078689 DOI: 10.1021/ol062045w  1
2006 Chen X, Chong CR, Shi L, Yoshimoto T, Sullivan DJ, Liu JO. Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity. Proceedings of the National Academy of Sciences of the United States of America. 103: 14548-53. PMID 16983082 DOI: 10.1073/pnas.0604101103  1
2006 Lu J, Chong CR, Hu X, Liu JO. Fumarranol, a rearranged fumagillin analogue that inhibits angiogenesis in vivo. Journal of Medicinal Chemistry. 49: 5645-8. PMID 16970390 DOI: 10.1021/jm060559v  1
2006 Dang Y, Kedersha N, Low WK, Romo D, Gorospe M, Kaufman R, Anderson P, Liu JO. Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. The Journal of Biological Chemistry. 281: 32870-8. PMID 16951406 DOI: 10.1074/jbc.M606149200  1
2006 Kim H, Kim BY, Soh JW, Cho EJ, Liu JO, Youn HD. A novel function of Nur77: physical and functional association with protein kinase C. Biochemical and Biophysical Research Communications. 348: 950-6. PMID 16904076 DOI: 10.1016/j.bbrc.2006.07.167  1
2006 Ma D, Zou B, Cai G, Hu X, Liu JO. Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 7615-26. PMID 16832801 DOI: 10.1002/chem.200600599  1
2006 Chong CR, Chen X, Shi L, Liu JO, Sullivan DJ. A clinical drug library screen identifies astemizole as an antimalarial agent. Nature Chemical Biology. 2: 415-6. PMID 16816845 DOI: 10.1038/nchembio806  1
2006 Hu X, Addlagatta A, Matthews BW, Liu JO. Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases. Angewandte Chemie (International Ed. in English). 45: 3772-5. PMID 16724298 DOI: 10.1002/anie.200600757  1
2006 Chong CR, Qian DZ, Pan F, Wei Y, Pili R, Sullivan DJ, Liu JO. Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. Journal of Medicinal Chemistry. 49: 2677-80. PMID 16640327 DOI: 10.1021/jm051225t  1
2005 Low WK, Dang Y, Schneider-Poetsch T, Shi Z, Choi NS, Merrick WC, Romo D, Liu JO. Inhibition of eukaryotic translation initiation by the marine natural product pateamine A. Molecular Cell. 20: 709-22. PMID 16337595 DOI: 10.1016/j.molcel.2005.10.008  1
2005 Shi B, Tang P, Hu X, Liu JO, Yu B. OSW saponins: facile synthesis toward a new type of structures with potent antitumor activities. The Journal of Organic Chemistry. 70: 10354-67. PMID 16323845 DOI: 10.1021/jo051536b  1
2005 Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 44: 14741-9. PMID 16274222 DOI: 10.1021/bi051691k  1
2005 Pan F, Means AR, Liu JO. Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. The Embo Journal. 24: 2104-13. PMID 15902271 DOI: 10.1038/sj.emboj.7600685  1
2005 Addlagatta A, Quillin ML, Omotoso O, Liu JO, Matthews BW. Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome. Biochemistry. 44: 7166-74. PMID 15882055 DOI: 10.1021/bi0501176  1
2005 Wang S, Dong Y, Wang X, Hu X, Liu JO, Hu Y. 3-Aryl beta-carbolin-1-ones as a new class of potent inhibitors of tumor cell proliferation: synthesis and biological evaluation. Organic & Biomolecular Chemistry. 3: 911-6. PMID 15731878 DOI: 10.1039/b412921k  1
2005 Liu JO. The yins of T cell activation. Science's Stke : Signal Transduction Knowledge Environment. 2005: re1. PMID 15632417 DOI: 10.1126/stke.2652005re1  1
2005 Han A, He J, Wu Y, Liu JO, Chen L. Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. Journal of Molecular Biology. 345: 91-102. PMID 15567413 DOI: 10.1016/j.jmb.2004.10.033  1
2004 Boxem M, Tsai CW, Zhang Y, Saito RM, Liu JO. The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation. Febs Letters. 576: 245-50. PMID 15474045 DOI: 10.1016/j.febslet.2004.08.077  1
2004 Romo D, Choi NS, Li S, Buchler I, Shi Z, Liu JO. Evidence for separate binding and scaffolding domains in the immunosuppressive and antitumor marine natural product, pateamine a: design, synthesis, and activity studies leading to a potent simplified derivative. Journal of the American Chemical Society. 126: 10582-8. PMID 15327314 DOI: 10.1021/ja040065s  1
2004 Wang S, Sun J, Yu G, Hu X, Liu JO, Hu Y. CuI catalyzed N-arylation of amide as a key step for the preparation of 3-aryl beta-carbolin-1-ones. Organic & Biomolecular Chemistry. 2: 1573-4. PMID 15162205 DOI: 10.1039/b406046f  1
2004 Choi JW, Park SC, Kang GH, Liu JO, Youn HD. Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma. Cancer Research. 64: 35-9. PMID 14729605 DOI: 10.1158/0008-5472.CAN-03-0145  1
2004 Pan F, Ye Z, Cheng L, Liu JO. Myocyte enhancer factor 2 mediates calcium-dependent transcription of the interleukin-2 gene in T lymphocytes: a calcium signaling module that is distinct from but collaborates with the nuclear factor of activated T cells (NFAT). The Journal of Biological Chemistry. 279: 14477-80. PMID 14722108 DOI: 10.1074/jbc.C300487200  1
2003 Liu JO. Endogenous protein inhibitors of calcineurin. Biochemical and Biophysical Research Communications. 311: 1103-9. PMID 14623296 DOI: 10.1016/j.bbrc.2003.10.020  1
2003 Kim H, Lee JE, Cho EJ, Liu JO, Youn HD. Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex. Cancer Research. 63: 6135-9. PMID 14559791  1
2003 Zhou G, Tsai CW, Liu JO. Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis. Journal of Medicinal Chemistry. 46: 3452-4. PMID 12877582 DOI: 10.1021/jm0341103  1
2003 He H, Dang Y, Dai F, Guo Z, Wu J, She X, Pei Y, Chen Y, Ling W, Wu C, Zhao S, Liu JO, Yu L. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. The Journal of Biological Chemistry. 278: 29278-87. PMID 12740394 DOI: 10.1074/jbc.M303800200  1
2003 Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. Nature. 422: 730-4. PMID 12700764 DOI: 10.1038/nature01555  1
2002 Huai Q, Kim HY, Liu Y, Zhao Y, Mondragon A, Liu JO, Ke H. Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. Proceedings of the National Academy of Sciences of the United States of America. 99: 12037-42. PMID 12218175 DOI: 10.1073/pnas.192206699  1
2002 Kim MJ, Jo DG, Hong GS, Kim BJ, Lai M, Cho DH, Kim KW, Bandyopadhyay A, Hong YM, Kim DH, Cho C, Liu JO, Snyder SH, Jung YK. Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Proceedings of the National Academy of Sciences of the United States of America. 99: 9870-5. PMID 12114545 DOI: 10.1073/pnas.152336999  1
2002 Smulik JA, Diver ST, Pan F, Liu JO. Synthesis of cyclosporin A-derived affinity reagents by olefin metathesis. Organic Letters. 4: 2051-4. PMID 12049515  1
2001 Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J. Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells Journal of Experimental Medicine. 194: 1449-1459. PMID 11714752 DOI: 10.1084/jem.194.10.1449  1
2001 Baumgrass R, Weiwad M, Erdmann F, Liu JO, Wunderlich D, Grabley S, Fischer G. Reversible Inhibition of Calcineurin by the Polyphenolic Aldehyde Gossypol Journal of Biological Chemistry. 276: 47914-47921. PMID 11598106  1
2001 Zhang LH, Youn HD, Liu JO. Inhibition of Cell Cycle Progression by the Novel Cyclophilin Ligand Sanglifehrin A Is Mediated through the NFκB-dependent Activation of p53 Journal of Biological Chemistry. 276: 43534-43540. PMID 11557753 DOI: 10.1074/jbc.M104257200  1
2001 Liu W, Youn HD, Liu JO. Thapsigargin-induced apoptosis involves Cabin1-MEF2-mediated induction of Nur77 European Journal of Immunology. 31: 1757-1764. PMID 11385620 DOI: 10.1002/1521-4141(200106)31:6<1757::AID-IMMU1757>3.0.CO;2-J  1
2001 Liu W, Youn HD, Zhou XZ, Lu KP, Liu JO. Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis-trans isomerase Pin1 Febs Letters. 496: 105-108. PMID 11356192 DOI: 10.1016/S0014-5793(01)02411-5  1
2001 Zhang LH, Liu JO. Sanglifehrin A, a novel cyclophilin-binding immunosuppressant, inhibits IL-2-dependent T cell proliferation at the G1 phase of the cell cycle Journal of Immunology. 166: 5611-5618. PMID 11313401  1
2000 Griffith EC, Licitra EJ, Liu JO. Yeast three-hybrid system for detecting ligand-receptor interactions Methods in Enzymology. 328: 89-103. PMID 11075340  1
2000 Youn HD, Chatila TA, Liu JO. Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis Embo Journal. 19: 4323-4331. PMID 10944115  1
2000 Youn HD, Liu JO. Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 Immunity. 13: 85-94. PMID 10933397  1
2000 Zhang Y, Griffith EC, Sage J, Jacks T, Liu JO. Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1. Proceedings of the National Academy of Sciences of the United States of America. 97: 6427-32. PMID 10841547 DOI: 10.1073/pnas.97.12.6427  1
2000 Youn HD, Grozinger CM, Liu JO. Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4. The Journal of Biological Chemistry. 275: 22563-7. PMID 10825153 DOI: 10.1074/jbc.C000304200  1
2000 Dai X, Su Z, Liu JO. An improved synthesis of a selective αvβ3-integrin antagonist cyclo(-RGDfK-) Tetrahedron Letters. 41: 6295-6298.  1
1999 Turk BE, Griffith EC, Wolf S, Biemann K, Chang YH, Liu JO. Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells. Chemistry & Biology. 6: 823-33. PMID 10574784 DOI: 10.1016/S1074-5521(99)80129-X  1
1999 Youn HD, Sun L, Prywes R, Liu JO. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Science (New York, N.Y.). 286: 790-3. PMID 10531067 DOI: 10.1126/science.286.5440.790  1
1999 Liu JO. Recruitment of proteins to modulate protein-protein interactions Chemistry and Biology. 6. PMID 10421765 DOI: 10.1016/S1074-5521(99)80080-5  1
1998 Niwayama S, Loh C, Turk BE, Liu JO, Miyachi H, Hashimoto Y. Enhanced potency of perfluorinated thalidomide derivatives for inhibition of LPS-induced tumor necrosis factor-α production is associated with a change of mechanism of action Bioorganic and Medicinal Chemistry Letters. 8: 1071-1076. PMID 9871710 DOI: 10.1016/S0960-894X(98)00171-1  1
1998 Griffith EC, Zhuang SU, Niwayama S, Ramsay CA, Chang YH, Liu JO. Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2 Proceedings of the National Academy of Sciences of the United States of America. 95: 15183-15188. PMID 9860943 DOI: 10.1073/pnas.95.26.15183  1
1998 Turk BE, Su Z, Liu JO. Synthetic analogues of TNP-470 and ovalicin reveal a common molecular basis for inhibition of angiogenesis and immunosuppression Bioorganic and Medicinal Chemistry. 6: 1163-1169. PMID 9784858 DOI: 10.1016/S0968-0896(98)00078-9  1
1998 Miyachi H, Koiso Y, Shirai R, Niwayama S, Liu JO, Hashimoto Y. Tumor necrosis factor-alpha production enhancing activity of substituted 3'-methylthalidomide: Influence of substituents at the phthaloyl moiety on the activity and stereoselectivity Chemical and Pharmaceutical Bulletin. 46: 1165-1168. PMID 9692223  1
1998 Sun L, Youn HD, Loh C, Stolow M, He W, Liu JO. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes Immunity. 8: 703-711. PMID 9655484 DOI: 10.1016/S1074-7613(00)80575-0  1
1998 Romo D, Rzasa RM, Shea HA, Park K, Langenhan JM, Sun L, Akhiezer A, Liu JO. Total synthesis and immunosuppressive activity of (-)-pateamine A and related compounds: Implementation of a β-lactam-based macrocyclization Journal of the American Chemical Society. 120: 12237-12254. DOI: 10.1021/ja981846u  1
1997 Jiang H, Xiong F, Kong S, Ogawa T, Kobayashi M, Liu JO. Distinct tissue and cellular distribution of two major isoforms of calcineurin Molecular Immunology. 34: 663-669. PMID 9393969 DOI: 10.1016/S0161-5890(97)00054-0  1
1997 Lanni JS, Lowe SW, Licitra EJ, Liu JO, Jacks T. p53-independent apoptosis induced by paclitaxel through an indirect mechanism Proceedings of the National Academy of Sciences of the United States of America. 94: 9679-9683. PMID 9275183 DOI: 10.1073/pnas.94.18.9679  1
1997 Griffith EC, Su Z, Turk BE, Chen S, Chang YH, Wu Z, Biemann K, Liu JO. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chemistry & Biology. 4: 461-71. PMID 9224570  1
1997 Mondragon A, Griffith EC, Sun L, Xiong F, Armstrong C, Liu JO. Overexpression and purification of human calcineurin alpha from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center. Biochemistry. 36: 4934-42. PMID 9125515 DOI: 10.1021/bi9631935  1
1996 Licitra EJ, Liu JO. A three-hybrid system for detecting small ligand-protein receptor interactions Proceedings of the National Academy of Sciences of the United States of America. 93: 12817-12821. PMID 8917502 DOI: 10.1073/pnas.93.23.12817  1
1996 Niwayama S, Turk BE, Liu JO. Potent inhibition of tumor necrosis factor-α production by tetrafluorothalidomide and tetrafluorophthalimides Journal of Medicinal Chemistry. 39: 3044-3045. PMID 8759624 DOI: 10.1021/jm960284r  1
1996 Turk BE, Jiang H, Liu JO. Binding of thalidomide to α1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor α production Proceedings of the National Academy of Sciences of the United States of America. 93: 7552-7556. PMID 8755512 DOI: 10.1073/pnas.93.15.7552  1
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