Yuk Yin Sham, Ph.D. - Publications

Affiliations: 
1994-1999 Chemistry University of Southern California, Los Angeles, CA, United States 
 1999-2000 National Cancer Institue-NIH 
 2001-2002 IBM T.J. Watson Research Center 
 2002- University of Minnesota, Twin Cities, Minneapolis, MN 

47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zafar S, Nguyen ME, Muthyala R, Jabeen I, Sham YY. Modeling and Simulation of GAT1: A Mechanistic Investigation of the GABA Transport Process. Computational and Structural Biotechnology Journal. 17: 61-69. PMID 30619541 DOI: 10.1016/j.csbj.2018.12.003  1
2018 Houang EM, Sham YY, Bates FS, Metzger JM. Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers. Skeletal Muscle. 8: 31. PMID 30305165 DOI: 10.1186/s13395-018-0177-7  1
2018 Vetter AD, Houang EM, Sell JJ, Thompson BR, Sham YY, Metzger JM. TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility. Biophysical Journal. 114: 1646-1656. PMID 29642034 DOI: 10.1016/j.bpj.2018.02.015  1
2017 Houang EM, Bates FS, Sham YY, Metzger JM. All-Atom Molecular Dynamics-Based Analysis of Membrane Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions. The Journal of Physical Chemistry. B. PMID 29049887 DOI: 10.1021/acs.jpcb.7b08938  1
2017 Houang EM, Haman KJ, Kim M, Zhang W, Lowe DA, Sham YY, Lodge TP, Hackel BJ, Bates FS, Metzger JM. Chemical endgroup modified diblock copolymers elucidate anchor and chain mechanism of membrane stabilization. Molecular Pharmaceutics. PMID 28538101 DOI: 10.1021/acs.molpharmaceut.7b00197  1
2017 Cote JM, Ramirez-Mondragon CA, Siegel ZS, Czyzyk DJ, Gao J, Sham YY, Mukerji I, Taylor EA. The Stories Tryptophans Tell: Exploring Protein Dynamics of Heptosyltransferase I from Escherichia coli. Biochemistry. PMID 28098447 DOI: 10.1021/acs.biochem.6b00850  1
2015 Akgün E, Javed MI, Lunzer MM, Powers MD, Sham YY, Watanabe Y, Portoghese PS. Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5). Journal of Medicinal Chemistry. PMID 26451468 DOI: 10.1021/acs.jmedchem.5b01245  1
2015 Muthyala R, Shin WS, Xie J, Sham YY. Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia. Bioorganic & Medicinal Chemistry Letters. 25: 4320-4. PMID 26264503 DOI: 10.1016/j.bmcl.2015.07.065  1
2014 Zhuang C, Sheng C, Shin WS, Wu Y, Li J, Yao J, Dong G, Zhang W, Sham YY, Miao Z, Zhang W. A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways. Oncotarget. 5: 10830-9. PMID 25350970  1
2014 Thompson BR, Houang EM, Sham YY, Metzger JM. Molecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residues. Biophysical Journal. 106: 2105-14. PMID 24853739 DOI: 10.1016/j.bpj.2014.04.017  1
2014 Muthyala R, Rastogi N, Shin WS, Peterson ML, Sham YY. Cell permeable vanX inhibitors as vancomycin re-sensitizing agents Bioorganic and Medicinal Chemistry Letters. 24: 2535-2538. PMID 24751446 DOI: 10.1016/j.bmcl.2014.03.097  1
2014 Zhuang C, Narayanapillai S, Zhang W, Sham YY, Xing C. Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search. Journal of Medicinal Chemistry. 57: 1121-6. PMID 24417449 DOI: 10.1021/jm4017174  1
2014 Zhou W, Chen F, Klyachkin Y, Sham YY, Geraghty RJ. Mutations in the amino terminus of herpes simplex virus type 1 gL can reduce cell-cell fusion without affecting gH/gL trafficking. Journal of Virology. 88: 739-44. PMID 24155377 DOI: 10.1128/JVI.02383-13  1
2013 Ferreira R, Artali R, Benoit A, Gargallo R, Eritja R, Ferguson DM, Sham YY, Mazzini S. Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines. Plos One. 8: e57701. PMID 23554865 DOI: 10.1371/journal.pone.0057701  1
2012 Sirivolu VR, Vernekar SK, Marchand C, Naumova A, Chergui A, Renaud A, Stephen AG, Chen F, Sham YY, Pommier Y, Wang Z. 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I. Journal of Medicinal Chemistry. 55: 8671-84. PMID 23006064 DOI: 10.1021/jm3008773  1
2012 Palpant NJ, Houang EM, Sham YY, Metzger JM. pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I. Biophysical Journal. 102: 1570-9. PMID 22500757 DOI: 10.1016/j.bpj.2012.01.024  1
2012 Chen YL, Tang J, Kesler MJ, Sham YY, Vince R, Geraghty RJ, Wang Z. The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus. Bioorganic & Medicinal Chemistry. 20: 467-79. PMID 22100256 DOI: 10.1016/j.bmc.2011.10.058  1
2011 Li L, Sham YY, Bikadi Z, Elmquist WF. pH-Dependent transport of pemetrexed by breast cancer resistance protein. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1478-85. PMID 21628496 DOI: 10.1124/dmd.111.039370  1
2011 Wilson DJ, Shi C, Duckworth BP, Muretta JM, Manjunatha U, Sham YY, Thomas DD, Aldrich CC. A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis. Analytical Biochemistry. 416: 27-38. PMID 21621502 DOI: 10.1016/j.ab.2011.05.003  1
2011 Tang J, Maddali K, Dreis CD, Sham YY, Vince R, Pommier Y, Wang Z. N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase. Acs Medicinal Chemistry Letters. 2: 63-67. PMID 21499541 DOI: 10.1021/ml1002162  1
2011 Tang J, Maddali K, Dreis CD, Sham YY, Vince R, Pommier Y, Wang Z. 6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase. Bioorganic & Medicinal Chemistry Letters. 21: 2400-2. PMID 21392991 DOI: 10.1016/j.bmcl.2011.02.069  1
2011 Tang J, Maddali K, Metifiot M, Sham YY, Vince R, Pommier Y, Wang Z. 3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integrase. Journal of Medicinal Chemistry. 54: 2282-92. PMID 21381765 DOI: 10.1021/jm1014378  1
2010 Chen L, Petrelli R, Gao G, Wilson DJ, McLean GT, Jayaram HN, Sham YY, Pankiewicz KW. Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure. Bioorganic & Medicinal Chemistry. 18: 5950-64. PMID 20650640 DOI: 10.1016/j.bmc.2010.06.081  1
2010 Chen L, Wilson DJ, Xu Y, Aldrich CC, Felczak K, Sham YY, Pankiewicz KW. Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis. Journal of Medicinal Chemistry. 53: 4768-78. PMID 20491506 DOI: 10.1021/jm100424m  1
2010 Tang J, Maddali K, Pommier Y, Sham YY, Wang Z. Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited. Bioorganic & Medicinal Chemistry Letters. 20: 3275-9. PMID 20457521 DOI: 10.1016/j.bmcl.2010.04.048  1
2010 Palpant NJ, Houang EM, Delport W, Hastings KE, Onufriev AV, Sham YY, Metzger JM. Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations. Physiological Genomics. 42: 287-99. PMID 20423961 DOI: 10.1152/physiolgenomics.00033.2010  1
2010 Lu D, Sham YY, Vince R. Design, asymmetric synthesis, and evaluation of pseudosymmetric sulfoximine inhibitors against HIV-1 protease. Bioorganic & Medicinal Chemistry. 18: 2037-48. PMID 20138769 DOI: 10.1016/j.bmc.2010.01.020  1
2009 Petrelli R, Sham YY, Chen L, Felczak K, Bennett E, Wilson D, Aldrich C, Yu JS, Cappellacci L, Franchetti P, Grifantini M, Mazzola F, Di Stefano M, Magni G, Pankiewicz KW. Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues. Bioorganic & Medicinal Chemistry. 17: 5656-64. PMID 19596199 DOI: 10.1016/j.bmc.2009.06.013  1
2009 Cohen DN, Sham YY, Haugstad GD, Xiang Y, Rossmann MG, Anderson DL, Popham DL. Shared catalysis in virus entry and bacterial cell wall depolymerization. Journal of Molecular Biology. 387: 607-18. PMID 19361422 DOI: 10.1016/j.jmb.2009.02.001  1
2008 Raza A, Sham YY, Vince R. Design and synthesis of sulfoximine based inhibitors for HIV-1 protease. Bioorganic & Medicinal Chemistry Letters. 18: 5406-10. PMID 18829317 DOI: 10.1016/j.bmcl.2008.09.044  1
2007 Chou TF, Sham YY, Wagner CR. Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity. Biochemistry. 46: 13074-9. PMID 17939685 DOI: 10.1021/bi701244h  1
2007 Xing C, Wang L, Tang X, Sham YY. Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1. Bioorganic & Medicinal Chemistry. 15: 2167-76. PMID 17227711 DOI: 10.1016/j.bmc.2006.12.020  1
2007 Ma L, Sham YY, Walters KJ, Towle HC. A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription. Nucleic Acids Research. 35: 35-44. PMID 17148476 DOI: 10.1093/nar/gkl987  1
2006 Kumar V, Locuson CW, Sham YY, Tracy TS. Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1688-96. PMID 16815961 DOI: 10.1124/dmd.106.010678  1
2005 Zhang Y, Sham YY, Rajamani R, Gao J, Portoghese PS. Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system. Chembiochem : a European Journal of Chemical Biology. 6: 853-9. PMID 15776407 DOI: 10.1002/cbic.200400207  1
2002 Sham YY, Ma B, Tsai CJ, Nussinov R. Thermal unfolding molecular dynamics simulation of Escherichia coli dihydrofolate reductase: Thermal stability of protein domains and unfolding pathway Proteins: Structure, Function and Genetics. 46: 308-320. PMID 11835506 DOI: 10.1002/prot.10040  1
2001 Tsai CJ, Buyong M, Sham YY, Kumar S, Nussinov R. Structured disorder and conformational selection Proteins: Structure, Function and Genetics. 44: 418-427. PMID 11484219 DOI: 10.1002/prot.1107  1
2001 Kumar S, Sham YY, Tsai CJ, Nussinov R. Protein folding and function: The N-terminal fragment in adenylate kinase Biophysical Journal. 80: 2439-2454. PMID 11325743  1
2001 Tsai CJ, Ma B, Sham YY, Kumar S, Wolfson HJ, Nussinov R. A hierarchical, building-block-based computational scheme for protein structure prediction Ibm Journal of Research and Development. 45: 513-523.  1
2000 Villa J, Strajbl M, Glennon TM, Sham YY, Chu ZT, Warshel A. How important are entropic contributions to enzyme catalysis? Proceedings of the National Academy of Sciences of the United States of America. 97: 11899-904. PMID 11050223 DOI: 10.1073/pnas.97.22.11899  1
2000 Sham YY, Chu ZT, Tao H, Warshel A. Examining methods for calculations of binding free energies: LRA, LIE, PDLD-LRA, and PDLD/S-LRA calculations of ligands binding to an HIV protease. Proteins. 39: 393-407. PMID 10813821 DOI: 10.1002/(SICI)1097-0134(20000601)39:4<393::AID-PROT120>3.0.CO;2-H  1
2000 Strajbl M, Sham YY, Villà J, Chu ZT, Warshel A. Calculations of Activation Entropies of Chemical Reactions in Solution Journal of Physical Chemistry B. 104: 4578-4584.  1
1999 Sham YY, Muegge I, Warshel A. Simulating proton translocations in proteins: probing proton transfer pathways in the Rhodobacter sphaeroides reaction center. Proteins. 36: 484-500. PMID 10450091 DOI: 10.1002/(SICI)1097-0134(19990901)36:4<484::AID-PROT13>3.0.CO;2-R  1
1998 Sham YY, Muegge I, Warshel A. The effect of protein relaxation on charge-charge interactions and dielectric constants of proteins. Biophysical Journal. 74: 1744-53. PMID 9545037 DOI: 10.1016/S0006-3495(98)77885-3  1
1998 Sham YY, Warshel A. The surface constraint all atom model provides size independent results in calculations of hydration free energies Journal of Chemical Physics. 109: 7940-7944. DOI: 10.1063/1.477441  1
1997 Sham YY, Chu ZT, Warshel A. Consistent calculations of pKa's of ionizable residues in proteins: Semi-microscopic and microscopic approaches Journal of Physical Chemistry B. 101: 4458-4472.  1
1995 Sham YY, Joens JA. Temperature dependent near UV molar absorptivities of several small aldehydes in aqueous solution Spectrochimica Acta Part a: Molecular and Biomolecular Spectroscopy. 51: 247-251. DOI: 10.1016/0584-8539(94)E0089-S  1
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