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Philip Awadalla - Publications

2007-2015 Pediatrics Université de Montréal, Montréal, Canada 
 2015- Molecular Genetics University of Toronto, Toronto, ON, Canada 
Population Genetics, Evolution, Disease Genomics

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Ang Houle A, Gibling H, Lamaze FC, Edgington HA, Soave D, Fave MJ, Agbessi M, Bruat V, Stein LD, Awadalla P. Aberrant expression impacts the pan-cancer genomic landscape. Genome Research. PMID 30341163 DOI: 10.1101/gr.231696.117  0.88
2018 Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao Z, Cirlan I, ... ... Awadalla P, et al. Prediction of acute myeloid leukaemia risk in healthy individuals. Nature. PMID 29988082 DOI: 10.1038/s41586-018-0317-6  0.72
2018 Favé MJ, Lamaze FC, Soave D, Hodgkinson A, Gauvin H, Bruat V, Grenier JC, Gbeha E, Skead K, Smargiassi A, Johnson M, Idaghdour Y, Awadalla P. Gene-by-environment interactions in urban populations modulate risk phenotypes. Nature Communications. 9: 827. PMID 29511166 DOI: 10.1038/s41467-018-03202-2  1
2017 Peischl S, Dupanloup I, Foucal A, Jomphe M, Bruat V, Grenier JC, Gouy A, Gilbert KJ, Gbeha E, Bosshard L, Hip-Ki E, Agbessi M, Hodgkinson A, Vézina H, Awadalla P, et al. Relaxed Selection During a Recent Human Expansion. Genetics. PMID 29187508 DOI: 10.1534/genetics.117.300551  0.88
2017 Alves I, Houle AA, Hussin JG, Awadalla P. The impact of recombination on human mutation load and disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 372. PMID 29109227 DOI: 10.1098/rstb.2016.0465  0.76
2016 Hodgkinson A, Grenier JC, Gbeha E, Awadalla P. A haplotype-based normalization technique for the analysis and detection of allele specific expression. Bmc Bioinformatics. 17: 364. PMID 27618913 DOI: 10.1186/s12859-016-1238-8  1
2016 Anand SS, Tu JV, Awadalla P, Black S, Boileau C, Busseuil D, Desai D, Després JP, de Souza RJ, Dummer T, Jacquemont S, Knoppers B, Larose E, Lear SA, Marcotte F, et al. Rationale, design, and methods for Canadian alliance for healthy hearts and minds cohort study (CAHHM) - a Pan Canadian cohort study. Bmc Public Health. 16: 650. PMID 27464510 DOI: 10.1186/s12889-016-3310-8  1
2016 Kukurba KR, Parsana P, Balliu B, Smith KS, Zappala Z, Knowles DA, Favé MJ, Davis JR, Li X, Zhu X, Potash JB, Weissman MM, Shi J, Kundaje A, Levinson DF, ... Awadalla P, et al. Impact of the X Chromosome and sex on regulatory variation. Genome Research. PMID 27197214 DOI: 10.1101/gr.197897.115  1
2016 Merner ND, Mercado A, Khanna AR, Hodgkinson A, Bruat V, Awadalla P, Gamba G, Rouleau GA, Kahle KT. Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia. Journal of Psychiatric Research. 77: 22-26. PMID 26955005 DOI: 10.1016/j.jpsychires.2016.02.016  1
2016 Gomez S, Diawara A, Gbeha E, Awadalla P, Sanni A, Idaghdour Y, Rahimy MC. Comparative Analysis of Iron Homeostasis in Sub-Saharan African Children with Sickle Cell Disease and Their Unaffected Siblings. Frontiers in Pediatrics. 4: 8. PMID 26942167 DOI: 10.3389/fped.2016.00008  1
2016 Troyanov S, Delmas-Frenette C, Bollée G, Youhanna S, Bruat V, Awadalla P, Devuyst O, Madore F. Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion. Clinical Journal of the American Society of Nephrology : Cjasn. 11: 62-9. PMID 26683887 DOI: 10.2215/CJN.04770415  1
2016 Bourdeau I, Oble S, Magne F, Lévesque I, Caceres K, Nolet S, Awadalla P, Tremblay J, Hamet P, Fragoso MC, Lacroix A. ARMC5 mutations in a large French-Canadian family with cortisol-secreting β-adrenergic/vasopressin responsive bilateral macronodular adrenal hyperplasia. European Journal of Endocrinology / European Federation of Endocrine Societies. 174: 85-96. PMID 26604299 DOI: 10.1530/EJE-15-0642  1
2015 Leblond CS, Gan-Or Z, Spiegelman D, Laurent SB, Szuto A, Hodgkinson A, Dionne-Laporte A, Provencher P, de Carvalho M, Orrù S, Brunet D, Bouchard JP, Awadalla P, Dupré N, Dion PA, et al. Replication study of MATR3 in familial and sporadic amyotrophic lateral sclerosis. Neurobiology of Aging. PMID 26493020 DOI: 10.1016/j.neurobiolaging.2015.09.013  0.88
2015 Wünnemann F, Kokta V, Leclerc S, Thibeault M, McCuaig C, Hatami A, Stheneur C, Grenier JC, Awadalla P, Mitchell GA, Andelfinger G, Preuss C. Aortic Dilatation Associated With a De Novo Mutation in the SOX18 Gene: Expanding the Clinical Spectrum of Hypotrichosis-Lymphedema-Telangiectasia Syndrome. The Canadian Journal of Cardiology. PMID 26148450 DOI: 10.1016/j.cjca.2015.04.004  1
2015 El-Bikai R, Tahir MR, Tremblay J, Joffres M, Šeda O, Šedová L, Awadalla P, Laberge C, Knoppers BM, Dumas P, Gaudet D, Ste-Marie LG, Hamet P. Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals. Journal of Hypertension. 33: 727-35; discussion 7. PMID 25915877 DOI: 10.1097/HJH.0000000000000475  1
2015 Hussin JG, Hodgkinson A, Idaghdour Y, Grenier JC, Goulet JP, Gbeha E, Hip-Ki E, Awadalla P. Recombination affects accumulation of damaging and disease-associated mutations in human populations. Nature Genetics. 47: 400-4. PMID 25685891 DOI: 10.1038/ng.3216  1
2014 Kahle KT, Merner ND, Friedel P, Silayeva L, Liang B, Khanna A, Shang Y, Lachance-Touchette P, Bourassa C, Levert A, Dion PA, Walcott B, Spiegelman D, Dionne-Laporte A, Hodgkinson A, ... Awadalla P, et al. Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy. Embo Reports. 15: 766-74. PMID 24928908 DOI: 10.15252/embr.201438840  1
2014 Hodgkinson A, Idaghdour Y, Gbeha E, Grenier JC, Hip-Ki E, Bruat V, Goulet JP, de Malliard T, Awadalla P. High-resolution genomic analysis of human mitochondrial RNA sequence variation. Science (New York, N.Y.). 344: 413-5. PMID 24763589 DOI: 10.1126/science.1251110  1
2014 Quinlan J, Idaghdour Y, Goulet JP, Gbeha E, de Malliard T, Bruat V, Grenier JC, Gomez S, Sanni A, Rahimy MC, Awadalla P. Genomic architecture of sickle cell disease in West African children. Frontiers in Genetics. 5: 26. PMID 24592274 DOI: 10.3389/fgene.2014.00026  1
2014 Verhave JC, Troyanov S, Mongeau F, Fradette L, Bouchard J, Awadalla P, Madore F. Prevalence, awareness, and management of CKD and cardiovascular risk factors in publicly funded health care. Clinical Journal of the American Society of Nephrology : Cjasn. 9: 713-9. PMID 24458079 DOI: 10.2215/CJN.06550613  1
2013 Casals F, Hodgkinson A, Hussin J, Idaghdour Y, Bruat V, de Maillard T, Grenier JC, Grenier JC, Gbeha E, Hamdan FF, Girard S, Spinella JF, Larivière M, Saillour V, Healy J, ... ... Awadalla P, et al. Whole-exome sequencing reveals a rapid change in the frequency of rare functional variants in a founding population of humans. Plos Genetics. 9: e1003815. PMID 24086152 DOI: 10.1371/journal.pgen.1003815  1
2013 Hodgkinson A, Casals F, Idaghdour Y, Grenier JC, Hernandez RD, Awadalla P. Selective constraint, background selection, and mutation accumulation variability within and between human populations. Bmc Genomics. 14: 495. PMID 23875710 DOI: 10.1186/1471-2164-14-495  1
2013 Zilversmit MM, Chase EK, Chen DS, Awadalla P, Day KP, McVean G. Hypervariable antigen genes in malaria have ancient roots. Bmc Evolutionary Biology. 13: 110. PMID 23725540 DOI: 10.1186/1471-2148-13-110  1
2013 Samuels ME, Majewski J, Alirezaie N, Fernandez I, Casals F, Patey N, Decaluwe H, Gosselin I, Haddad E, Hodgkinson A, Idaghdour Y, Marchand V, Michaud JL, Rodrigue MA, Desjardins S, ... ... Awadalla P, et al. Exome sequencing identifies mutations in the gene TTC7A in French-Canadian cases with hereditary multiple intestinal atresia. Journal of Medical Genetics. 50: 324-9. PMID 23423984 DOI: 10.1136/jmedgenet-2012-101483  1
2013 Hussin J, Sinnett D, Casals F, Idaghdour Y, Bruat V, Saillour V, Healy J, Grenier JC, de Malliard T, Busche S, Spinella JF, Larivière M, Gibson G, Andersson A, Holmfeldt L, ... ... Awadalla P, et al. Rare allelic forms of PRDM9 associated with childhood leukemogenesis. Genome Research. 23: 419-30. PMID 23222848 DOI: 10.1101/gr.144188.112  1
2013 Awadalla P, Boileau C, Payette Y, Idaghdour Y, Goulet JP, Knoppers B, Hamet P, Laberge C. Cohort profile of the CARTaGENE study: Quebec's population-based biobank for public health and personalized genomics. International Journal of Epidemiology. 42: 1285-99. PMID 23071140 DOI: 10.1093/ije/dys160  1
2013 Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, et al. Harnessing genomics to identify environmental determinants of heritable disease. Mutation Research. 752: 6-9. PMID 22935230 DOI: 10.1016/j.mrrev.2012.08.002  1
2012 Idaghdour Y, Awadalla P. Exploiting gene expression variation to capture gene-environment interactions for disease. Frontiers in Genetics. 3: 228. PMID 23755064 DOI: 10.3389/fgene.2012.00228  1
2012 Idaghdour Y, Quinlan J, Goulet JP, Berghout J, Gbeha E, Bruat V, de Malliard T, Grenier JC, Gomez S, Gros P, Rahimy MC, Sanni A, Awadalla P. Evidence for additive and interaction effects of host genotype and infection in malaria. Proceedings of the National Academy of Sciences of the United States of America. 109: 16786-93. PMID 22949651 DOI: 10.1073/pnas.1204945109  1
2012 Cartwright RA, Hussin J, Keebler JE, Stone EA, Awadalla P. A family-based probabilistic method for capturing de novo mutations from high-throughput short-read sequencing data. Statistical Applications in Genetics and Molecular Biology. 11. PMID 22499693 DOI: 10.2202/1544-6115.1713  1
2012 Casals F, Idaghdour Y, Hussin J, Awadalla P. Next-generation sequencing approaches for genetic mapping of complex diseases. Journal of Neuroimmunology. 248: 10-22. PMID 22285396 DOI: 10.1016/j.jneuroim.2011.12.017  1
2011 Hussin J, Roy-Gagnon MH, Gendron R, Andelfinger G, Awadalla P. Age-dependent recombination rates in human pedigrees. Plos Genetics. 7: e1002251. PMID 21912527 DOI: 10.1371/journal.pgen.1002251  1
2011 Casals F, Sikora M, Laayouni H, Montanucci L, Muntasell A, Lazarus R, Calafell F, Awadalla P, Netea MG, Bertranpetit J. Genetic adaptation of the antibacterial human innate immunity network. Bmc Evolutionary Biology. 11: 202. PMID 21745391 DOI: 10.1186/1471-2148-11-202  1
2011 Conrad DF, Keebler JE, DePristo MA, Lindsay SJ, Zhang Y, Casals F, Idaghdour Y, Hartl CL, Torroja C, Garimella KV, Zilversmit M, Cartwright R, Rouleau GA, Daly M, Stone EA, ... ... Awadalla P, et al. Variation in genome-wide mutation rates within and between human families. Nature Genetics. 43: 712-4. PMID 21666693 DOI: 10.1038/ng.862  1
2011 Laayouni H, Montanucci L, Sikora M, Melé M, Dall'Olio GM, Lorente-Galdos B, McGee KM, Graffelman J, Awadalla P, Bosch E, Comas D, Navarro A, Calafell F, Casals F, Bertranpetit J. Similarity in recombination rate estimates highly correlates with genetic differentiation in humans. Plos One. 6: e17913. PMID 21464928 DOI: 10.1371/journal.pone.0017913  1
2011 Jiang H, Li N, Gopalan V, Zilversmit MM, Varma S, Nagarajan V, Li J, Mu J, Hayton K, Henschen B, Yi M, Stephens R, McVean G, Awadalla P, Wellems TE, et al. High recombination rates and hotspots in a Plasmodium falciparum genetic cross. Genome Biology. 12: R33. PMID 21463505 DOI: 10.1186/gb-2011-12-4-r33  1
2011 Myers RA, Casals F, Gauthier J, Hamdan FF, Keebler J, Boyko AR, Bustamante CD, Piton AM, Spiegelman D, Henrion E, Zilversmit M, Hussin J, Quinlan J, Yang Y, Lafrenière RG, ... ... Awadalla P, et al. A population genetic approach to mapping neurological disorder genes using deep resequencing. Plos Genetics. 7: e1001318. PMID 21383861 DOI: 10.1371/journal.pgen.1001318  1
2011 Branch OH, Sutton PL, Barnes C, Castro JC, Hussin J, Awadalla P, Hijar G. Plasmodium falciparum genetic diversity maintained and amplified over 5 years of a low transmission endemic in the Peruvian Amazon. Molecular Biology and Evolution. 28: 1973-86. PMID 21109587 DOI: 10.1093/molbev/msq311  1
2010 Awadalla P, Gauthier J, Myers RA, Casals F, Hamdan FF, Griffing AR, Côté M, Henrion E, Spiegelman D, Tarabeux J, Piton A, Yang Y, Boyko A, Bustamante C, Xiong L, et al. Direct measure of the de novo mutation rate in autism and schizophrenia cohorts. American Journal of Human Genetics. 87: 316-24. PMID 20797689 DOI: 10.1016/j.ajhg.2010.07.019  1
2010 Guernsey DL, Jiang H, Hussin J, Arnold M, Bouyakdan K, Perry S, Babineau-Sturk T, Beis J, Dumas N, Evans SC, Ferguson M, Matsuoka M, Macgillivray C, Nightingale M, Patry L, ... ... Awadalla P, et al. Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. American Journal of Human Genetics. 87: 40-51. PMID 20598275 DOI: 10.1016/j.ajhg.2010.06.003  1
2010 Zilversmit MM, Volkman SK, DePristo MA, Wirth DF, Awadalla P, Hartl DL. Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome. Molecular Biology and Evolution. 27: 2198-209. PMID 20427419 DOI: 10.1093/molbev/msq108  1
2010 Gauthier J, Champagne N, Lafrenière RG, Xiong L, Spiegelman D, Brustein E, Lapointe M, Peng H, Côté M, Noreau A, Hamdan FF, Addington AM, Rapoport JL, Delisi LE, Krebs MO, ... ... Awadalla P, et al. De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 107: 7863-8. PMID 20385823 DOI: 10.1073/pnas.0906232107  1
2010 Mu J, Myers RA, Jiang H, Liu S, Ricklefs S, Waisberg M, Chotivanich K, Wilairatana P, Krudsood S, White NJ, Udomsangpetch R, Cui L, Ho M, Ou F, Li H, ... ... Awadalla P, et al. Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs. Nature Genetics. 42: 268-71. PMID 20101240 DOI: 10.1038/ng.528  1
2009 Cichon S, Craddock N, Daly M, Faraone SV, Gejman PV, Kelsoe J, Lehner T, Levinson DF, Moran A, Sklar P, Sullivan PF. Genomewide association studies: history, rationale, and prospects for psychiatric disorders. The American Journal of Psychiatry. 166: 540-56. PMID 19339359 DOI: 10.1176/appi.ajp.2008.08091354  1
2008 Prugnolle F, McGee K, Keebler J, Awadalla P. Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents. Bmc Evolutionary Biology. 8: 223. PMID 18667061 DOI: 10.1186/1471-2148-8-223  1
2007 Bockhorst J, Lu F, Janes JH, Keebler J, Gamain B, Awadalla P, Su Xz, Samudrala R, Jojic N, Smith JD. Structural polymorphism and diversifying selection on the pregnancy malaria vaccine candidate VAR2CSA Molecular and Biochemical Parasitology. 155: 103-112. PMID 17669514 DOI: 10.1016/j.molbiopara.2007.06.007  1
2007 Mu J, Awadalla P, Duan J, McGee KM, Keebler J, Seydel K, McVean GA, Su XZ. Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome. Nature Genetics. 39: 126-30. PMID 17159981 DOI: 10.1038/ng1924  1
2006 Jackson M, Watt AJ, Gautier P, Gilchrist D, Driehaus J, Graham GJ, Keebler J, Prugnolle F, Awadalla P, Forrester LM. A murine specific expansion of the Rhox cluster involved in embryonic stem cell biology is under natural selection. Bmc Genomics. 7: 212. PMID 16916441 DOI: 10.1186/1471-2164-7-212  1
2006 Trimnell AR, Kraemer SM, Mukherjee S, Phippard DJ, Janes JH, Flamoe E, Su XZ, Awadalla P, Smith JD. Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria. Molecular and Biochemical Parasitology. 148: 169-80. PMID 16697476 DOI: 10.1016/j.molbiopara.2006.03.012  1
2006 Carbone MA, Jordan KW, Lyman RF, Harbison ST, Leips J, Morgan TJ, DeLuca M, Awadalla P, Mackay TF. Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Drosophila. Current Biology : Cb. 16: 912-9. PMID 16682353 DOI: 10.1016/j.cub.2006.03.051  1
2005 Mu J, Awadalla P, Duan J, McGee KM, Joy DA, McVean GA, Su XZ. Recombination hotspots and population structure in Plasmodium falciparum. Plos Biology. 3: e335. PMID 16144426 DOI: 10.1371/journal.pbio.0030335  1
2004 Shimizu KK, Cork JM, Caicedo AL, Mays CA, Moore RC, Olsen KM, Ruzsa S, Coop G, Bustamante CD, Awadalla P, Purugganan MD. Darwinian selection on a selfing locus. Science (New York, N.Y.). 306: 2081-4. PMID 15604405 DOI: 10.1126/science.1103776  1
2004 Barbash DA, Awadalla P, Tarone AM. Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus. Plos Biology. 2: e142. PMID 15208709 DOI: 10.1371/journal.pbio.0020142  1
2004 Haydon DT, Bastos AD, Awadalla P. Low linkage disequilibrium indicative of recombination in foot-and-mouth disease virus gene sequence alignments. The Journal of General Virology. 85: 1095-100. PMID 15105526 DOI: 10.1099/vir.0.19588-0  1
2003 Charlesworth D, Mable BK, Schierup MH, Bartolomé C, Awadalla P. Diversity and linkage of genes in the self-incompatibility gene family in Arabidopsis lyrata. Genetics. 164: 1519-35. PMID 12930757  1
2003 Abdel-Muhsin AA, Mackinnon MJ, Awadalla P, Ali E, Suleiman S, Ahmed S, Walliker D, Babiker HA. Local differentiation in Plasmodium falciparum drug resistance genes in Sudan Parasitology. 126: 391-400. PMID 12793642 DOI: 10.1017/S0031182003003020  1
2003 Awadalla P. The evolutionary genomics of pathogen recombination. Nature Reviews. Genetics. 4: 50-60. PMID 12509753 DOI: 10.1038/nrg964  1
2002 McVean G, Awadalla P, Fearnhead P. A coalescent-based method for detecting and estimating recombination from gene sequences. Genetics. 160: 1231-41. PMID 11901136  1
2001 Awadalla P, Walliker D, Babiker H, Mackinnon M. The question of Plasmodium falciparum population structure Trends in Parasitology. 17: 351-353. PMID 11685887 DOI: 10.1016/S1471-4922(01)02034-7  1
2001 Eyre-Walker A, Awadalla P. Does human mtDNA recombine? Journal of Molecular Evolution. 53: 430-435. PMID 11675602 DOI: 10.1007/s002390010232  1
2001 Schierup MH, Mable BK, Awadalla P, Charlesworth D. Identification and characterization of a polymorphic receptor kinase gene linked to the self-incompatibility locus of Arabidopsis lyrata. Genetics. 158: 387-99. PMID 11333247  1
2000 Charlesworth D, Awadalla P, Mable BK, Schierup MH. Population-level studies of multiallelic serf-incompatibility loci, with particular reference to Brassicaceae Annals of Botany. 85: 227-239. DOI: 10.1006/anbo.1999.1015  1
1999 Awadalla P, Eyre-Walker A, Smith JM. Linkage disequilibrium and recombination in hominid mitochondrial DNA Science. 286: 2524-2525. PMID 10617471 DOI: 10.1126/science.286.5449.2524  1
1999 Awadalla P, Charlesworth D. Recombination and selection at Brassica self-incompatibility loci Genetics. 152: 413-425. PMID 10224271  1
1998 Charlesworth D, Awadalla P. Flowering plant self-incompatibility: The molecular population genetics of Brassica S-loci Heredity. 81: 1-9. PMID 9720299  1
1997 Awadalla P, Ritland K. Microsatellite variation and evolution in the Mimulus guttatus species complex with contrasting mating systems Molecular Biology and Evolution. 14: 1023-1034. PMID 9335142  1
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