Nabil G. Seidah - Publications

Affiliations: 
Biochemistry Université de Montréal, Montréal, Canada 
Area:
Biochemistry, Medicine and Surgery
Website:
https://en.wikipedia.org/wiki/Nabil_Seidah

201 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chong M, Yoon G, Susan-Resiga D, Chamberland A, Cheillan D, Paré G, Seidah NG. Hypolipidaemia among patients with PMM2-CDG is associated with low circulating PCSK9 levels: a case report followed by observational and experimental studies. Journal of Medical Genetics. PMID 31391289 DOI: 10.1136/jmedgenet-2019-106102  0.32
2019 Seidah NG, Prat A, Pirillo A, Catapano AL, Norata GD. Novel strategies to target PCSK9: beyond monoclonal antibodies. Cardiovascular Research. PMID 30629143 DOI: 10.1093/cvr/cvz003  0.32
2018 Kim K, Shim D, Lee JS, Zaitsev K, Williams JW, Kim KW, Jang MY, Seok Jang H, Yun TJ, Lee SH, Yoon WK, Prat A, Seidah NG, Choi J, Lee SP, et al. Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models. Circulation Research. 123: 1127-1142. PMID 30359200 DOI: 10.1161/CIRCRESAHA.118.312804  0.32
2018 Essalmani R, Weider E, Marcinkiewicz J, Chamberland A, Susan-Resig D, Roubtsova A, Seidah NG, Prat A. A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice. Biological Chemistry. PMID 30044755 DOI: 10.1515/hsz-2018-0194  0.32
2018 Grin PM, Dwivedi DJ, Chathely KM, Trigatti BL, Prat A, Seidah NG, Liaw PC, Fox-Robichaud AE. Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor. Scientific Reports. 8: 10496. PMID 30002483 DOI: 10.1038/s41598-018-28777-0  0.32
2018 Gauthier MS, Awan Z, Bouchard A, Champagne J, Tessier S, Faubert D, Chabot K, Garneau PY, Rabasa-Lhoret R, Seidah NG, Ridker PM, Genest J, Coulombe B. Posttranslational modification of proprotein convertase subtilisin/kexin type 9 is differentially regulated in response to distinct cardiometabolic treatments as revealed by targeted proteomics. Journal of Clinical Lipidology. PMID 29699916 DOI: 10.1016/j.jacl.2018.03.092  0.4
2018 Seidah NG, Chrétien M, Mbikay M. The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation. Current Opinion in Lipidology. PMID 29342010 DOI: 10.1097/MOL.0000000000000484  0.36
2017 Essalmani R, Susan-Resiga D, Guillemot J, Kim W, Sachan V, Awan Z, Chamberland A, Asselin MC, Ly K, Desjardins R, Day R, Prat A, Seidah NG. Thrombin activation of protein C requires prior processing by a liver proprotein convertase. The Journal of Biological Chemistry. 292: 13565. PMID 28821605 DOI: 10.1074/jbc.A116.77040  0.4
2017 Paquette M, Luna Saavedra YG, Chamberland A, Prat A, Christensen DL, Lajeunesse-Trempe F, Kaduka L, Seidah NG, Dufour R, Baass A. Association Between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population. Metabolic Syndrome and Related Disorders. PMID 28749722 DOI: 10.1089/met.2017.0027  0.52
2017 Essalmani R, Susan-Resiga D, Guillemot J, WooJin K, Sachan V, Awan Z, Chamberland A, Asselin MC, Ly K, Desjardins R, Day R, Prat A, Seidah NG. Thrombin Activation of Protein C Requires Prior Processing by a Liver Proprotein Convertase. The Journal of Biological Chemistry. PMID 28468828 DOI: 10.1074/jbc.M116.770040  0.4
2017 Coriati A, Arslanian E, Bouvet GF, Prat A, Seidah NG, Rabasa-Lhoret R, Berthiaume Y. Proprotein Convertase Subtilisin/Kexin type 9 affects insulin but not lipid metabolism in cystic fibrosis. Clinical and Investigative Medicine. Medecine Clinique Et Experimentale. 40: E59-E65. PMID 28447578  0.32
2017 Szumska D, Cioroch M, Keeling A, Prat A, Seidah NG, Bhattacharya S. Pcsk5 is required in the early cranio-cardiac mesoderm for heart development. Bmc Developmental Biology. 17: 6. PMID 28446132 DOI: 10.1186/s12861-017-0148-y  0.32
2017 Seidah NG, Abifadel M, Prost S, Boileau C, Prat A. The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9. Pharmacological Reviews. 69: 33-52. PMID 27920219 DOI: 10.1124/pr.116.012989  0.32
2016 Susan-Resiga D, Girard E, Kiss RS, Essalmani R, Hamelin J, Asselin MC, Awan Z, Butkinaree C, Fleury A, Soldera A, Dory YL, Baass A, Seidah NG. A novel mechanism causing familial hypercholesterolemia: The proprotein convertase subtilisin/kexin type 9-resistant Arg410Ser LDL receptor mutation. The Journal of Biological Chemistry. PMID 27998977 DOI: 10.1074/jbc.M116.769430  0.4
2016 Weider E, Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Nimesh S, Ashraf Y, Wycoff KL, Zhang J, Prat A, Seidah NG. Proprotein convertase subtilisin/Kexin type 9 (PCSK9) single domain antibodies are potent inhibitors of low density lipoprotein receptor degradation. The Journal of Biological Chemistry. 291: 26586. PMID 27986868 DOI: 10.1074/jbc.A116.717736  0.52
2016 Dwivedi DJ, Grin PM, Khan M, Prat A, Zhou J, Fox-Robichaud AE, Seidah NG, Liaw PC. Differential Expression of PCSK9 Modulates Infection, Inflammation and Coagulation in a Murine Model of Sepsis. Shock (Augusta, Ga.). PMID 27405064 DOI: 10.1097/SHK.0000000000000682  0.52
2016 Weider E, Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Ashraf Y, Wycoff KL, Zhang J, Prat A, Seidah NG. Proprotein convertase subtilisin/Kexin type 9 (PCSK9) single domain antibodies are potent inhibitors of LDL receptor degradation. The Journal of Biological Chemistry. PMID 27284008 DOI: 10.1074/jbc.M116.717736  0.52
2016 Seidah NG. New developments in proprotein convertase subtilisin-kexin 9's biology and clinical implications. Current Opinion in Lipidology. PMID 27031271 DOI: 10.1097/MOL.0000000000000295  0.52
2016 Guillemot J, Asselin MC, Susan-Resiga D, Essalmani R, Seidah NG. Deferoxamine stimulates LDLR expression and LDL uptake in HepG2 cells. Molecular Nutrition & Food Research. 60: 600-8. PMID 26577249 DOI: 10.1002/mnfr.201500467  0.52
2016 Awan Z, Denis M, Roubtsova A, Essalmani R, Marcinkiewicz J, Awan A, Gram H, Seidah NG, Genest J. Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia. Angiology. 67: 157-67. PMID 25904765 DOI: 10.1177/0003319715583205  0.4
2015 Gorski JP, Huffman NT, Vallejo J, Brotto L, Chittur SV, Breggia A, Stern A, Huang J, Mo C, Seidah NG, Bonewald L, Brotto M. Deletion of Mbtps1 (PCSK8, S1P, SKI-1) in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age. The Journal of Biological Chemistry. PMID 26719336 DOI: 10.1074/jbc.M115.686626  0.52
2015 Bhat M, Skill N, Marcus V, Deschenes M, Tan X, Bouteaud J, Negi S, Awan Z, Aikin R, Kwan J, Amre R, Tabaries S, Hassanain M, Seidah NG, Maluccio M, et al. Decreased PCSK9 expression in human hepatocellular carcinoma. Bmc Gastroenterology. 15: 176. PMID 26674961 DOI: 10.1186/s12876-015-0371-6  0.52
2015 Le Coupanec A, Desforges M, Meessen-Pinard M, Dubé M, Day R, Seidah NG, Talbot PJ. Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System. Plos Pathogens. 11: e1005261. PMID 26545254 DOI: 10.1371/journal.ppat.1005261  0.52
2015 Guillemot J, Seidah NG. PACE4 (PCSK6): another proprotein convertase link to iron homeostasis? Haematologica. 100: e377. PMID 26341526 DOI: 10.3324/haematol.2015.127175  0.52
2015 Armstrong SM, Sugiyama MG, Fung KY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu SN, Neculai D, Yin C, Bolz SS, Seidah NG, Cybulsky MI, Heit B, et al. A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. Cardiovascular Research. PMID 26334034 DOI: 10.1093/cvr/cvv218  0.52
2015 Roubtsova A, Chamberland A, Marcinkiewicz J, Essalmani R, Fazel A, Bergeron JJ, Seidah NG, Prat A. PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice. Journal of Lipid Research. 56: 2133-42. PMID 26323289 DOI: 10.1194/jlr.M061952  0.52
2015 Kim W, Zekas E, Lodge R, Susan-Resiga D, Marcinkiewicz E, Essalmani R, Mihara K, Ramachandran R, Asahchop E, Gelman B, Cohen ÉA, Power C, Hollenberg MD, Seidah NG. Neuroinflammation-induced interactions between protease-activated receptor 1 and proprotein convertases in HIV-associated neurocognitive disorder. Molecular and Cellular Biology. PMID 26283733 DOI: 10.1128/MCB.00764-15  0.52
2015 Le QT, Blanchet M, Seidah NG, Labonté P. Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9. The Journal of Biological Chemistry. 290: 23385-400. PMID 26195630 DOI: 10.1074/jbc.M115.642991  0.52
2015 Declercq J, Brouwers B, Pruniau VP, Stijnen P, Tuand K, Meulemans S, Prat A, Seidah NG, Khatib AM, Creemers JW. Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth. Biomed Research International. 2015: 148651. PMID 26167473 DOI: 10.1155/2015/148651  0.52
2015 Butkinaree C, Canuel M, Essalmani R, Poirier S, Benjannet S, Asselin MC, Roubtsova A, Hamelin J, Marcinkiewicz J, Chamberland A, Guillemot J, Mayer G, Sisodia SS, Jacob Y, Prat A, ... Seidah NG, et al. Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other. The Journal of Biological Chemistry. 290: 18609-20. PMID 26085104 DOI: 10.1074/jbc.M115.647180  0.52
2015 Bamimore MA, Zaid A, Banerjee Y, Al-Sarraf A, Abifadel M, Seidah NG, Al-Waili K, Al-Rasadi K, Awan Z. Familial hypercholesterolemia mutations in the Middle Eastern and North African region: a need for a national registry. Journal of Clinical Lipidology. 9: 187-94. PMID 25911074 DOI: 10.1016/j.jacl.2014.11.008  0.52
2015 Romagnuolo R, Scipione CA, Boffa MB, Marcovina SM, Seidah NG, Koschinsky ML. Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor. The Journal of Biological Chemistry. 290: 11649-62. PMID 25778403 DOI: 10.1074/jbc.M114.611988  0.52
2015 Gauthier MS, Pérusse JR, Awan Z, Bouchard A, Tessier S, Champagne J, Krastins B, Byram G, Chabot K, Garneau P, Rabasa-Lhoret R, Faubert D, Lopez MF, Seidah NG, Coulombe B. A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA-SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts. Methods (San Diego, Calif.). 81: 66-73. PMID 25770357 DOI: 10.1016/j.ymeth.2015.03.003  0.52
2015 Achilleos A, Huffman NT, Marcinkiewicyz E, Seidah NG, Chen Q, Dallas SL, Trainor PA, Gorski JP. MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral development†. Human Molecular Genetics. 24: 2884-98. PMID 25652402 DOI: 10.1093/hmg/ddv050  0.52
2015 Bridge SH, Sheridan DA, Felmlee DJ, Crossey MM, Fenwick FI, Lanyon CV, Dubuc G, Seidah NG, Davignon J, Thomas HC, Taylor-Robinson SD, Toms GL, Neely RD, Bassendine MF. PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: evidence for genotype-specific regulation of lipoprotein metabolism. Journal of Hepatology. 62: 763-70. PMID 25463543 DOI: 10.1016/j.jhep.2014.11.016  0.52
2014 da Palma JR, Burri DJ, Oppliger J, Salamina M, Cendron L, de Laureto PP, Seidah NG, Kunz S, Pasquato A. Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease. The Journal of Biological Chemistry. 289: 35743-56. PMID 25378398 DOI: 10.1074/jbc.M114.588525  0.52
2014 Guillemot J, Essalmani R, Hamelin J, Seidah NG. Is there a link between proprotein convertase PC7 activity and human lipid homeostasis? Febs Open Bio. 4: 741-5. PMID 25349778 DOI: 10.1016/j.fob.2014.08.004  0.52
2014 Duell PB, Dubuc G, Seidah NG, Davignon J. Clearance of plasma proprotein convertase subtilisin/kexin 9 by low-density lipoprotein apheresis. Circulation Research. 115: e3-4. PMID 24951769 DOI: 10.1161/CIRCRESAHA.114.304163  0.52
2014 Ly K, Saavedra YG, Canuel M, Routhier S, Desjardins R, Hamelin J, Mayne J, Lazure C, Seidah NG, Day R. Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9. The Journal of Biological Chemistry. 289: 17732-46. PMID 24808179 DOI: 10.1074/jbc.M113.541094  0.52
2014 Pedersen NB, Wang S, Narimatsu Y, Yang Z, Halim A, Schjoldager KTBG, Madsen TD, Seidah NG, Bennett EP, Levery SB, Clausen H. Low density lipoprotein receptor class A repeats are O-glycosylated in linker regions Journal of Biological Chemistry. 289: 17312-17324. PMID 24798328 DOI: 10.1074/jbc.M113.545053  0.52
2014 Awan Z, Dubuc G, Faraj M, Dufour R, Seidah NG, Davignon J, Rabasa-Lhoret R, Baass A. The effect of insulin on circulating PCSK9 in postmenopausal obese women. Clinical Biochemistry. 47: 1033-9. PMID 24721682 DOI: 10.1016/j.clinbiochem.2014.03.022  0.52
2014 Seidah NG, Awan Z, Chrétien M, Mbikay M. PCSK9: a key modulator of cardiovascular health. Circulation Research. 114: 1022-36. PMID 24625727 DOI: 10.1161/CIRCRESAHA.114.301621  0.52
2014 Harihar S, Pounds KM, Iwakuma T, Seidah NG, Welch DR. Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing. Plos One. 9: e84958. PMID 24454770 DOI: 10.1371/journal.pone.0084958  0.52
2013 Kim W, Seidah NG, Prat A. In utero measurement of heart rate in mouse by noninvasive M-mode echocardiography. Journal of Visualized Experiments : Jove. e50994. PMID 24300115 DOI: 10.3791/50994  0.52
2013 Awan Z, Choi HY, Stitziel N, Ruel I, Bamimore MA, Husa R, Gagnon MH, Wang RH, Peloso GM, Hegele RA, Seidah NG, Kathiresan S, Genest J. APOE p.Leu167del mutation in familial hypercholesterolemia. Atherosclerosis. 231: 218-22. PMID 24267230 DOI: 10.1016/j.atherosclerosis.2013.09.007  0.52
2013 Hipp MM, Shepherd D, Gileadi U, Aichinger MC, Kessler BM, Edelmann MJ, Essalmani R, Seidah NG, Reis e Sousa C, Cerundolo V. Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes. Immunity. 39: 711-21. PMID 24138882 DOI: 10.1016/j.immuni.2013.09.004  0.52
2013 Wetsel WC, Rodriguiz RM, Guillemot J, Rousselet E, Essalmani R, Kim IH, Bryant JC, Marcinkiewicz J, Desjardins R, Day R, Constam DB, Prat A, Seidah NG. Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 17362-7. PMID 24101515 DOI: 10.1073/pnas.1314698110  0.52
2013 Aerts L, Hamelin MÈ, Rhéaume C, Lavigne S, Couture C, Kim W, Susan-Resiga D, Prat A, Seidah NG, Vergnolle N, Riteau B, Boivin G. Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model. Plos One. 8: e72529. PMID 24015257 DOI: 10.1371/journal.pone.0072529  0.52
2013 Saavedra YG, Zhang J, Seidah NG. PCSK9 prosegment chimera as novel inhibitors of LDLR degradation. Plos One. 8: e72113. PMID 23951290 DOI: 10.1371/journal.pone.0072113  0.52
2013 Essalmani R, Susan-Resiga D, Chamberland A, Asselin MC, Canuel M, Constam D, Creemers JW, Day R, Gauthier D, Prat A, Seidah NG. Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. The Journal of Biological Chemistry. 288: 26410-8. PMID 23918928 DOI: 10.1074/jbc.M113.501304  0.52
2013 Seidah NG, Sadr MS, Chrétien M, Mbikay M. The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. The Journal of Biological Chemistry. 288: 21473-81. PMID 23775089 DOI: 10.1074/jbc.R113.481549  0.52
2013 Awan Z, Delvin EE, Levy E, Genest J, Davignon J, Seidah NG, Baass A. Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype. The Canadian Journal of Cardiology. 29: 927-33. PMID 23743349 DOI: 10.1016/j.cjca.2013.03.004  0.4
2013 Canuel M, Sun X, Asselin MC, Paramithiotis E, Prat A, Seidah NG. Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1). Plos One. 8: e64145. PMID 23675525 DOI: 10.1371/journal.pone.0064145  0.52
2013 Jänis MT, Tarasov K, Ta HX, Suoniemi M, Ekroos K, Hurme R, Lehtimäki T, Päivä H, Kleber ME, März W, Prat A, Seidah NG, Laaksonen R. Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency. Atherosclerosis. 228: 380-5. PMID 23623011 DOI: 10.1016/j.atherosclerosis.2013.03.029  0.52
2013 Pasquato A, Ramos da Palma J, Galan C, Seidah NG, Kunz S. Viral envelope glycoprotein processing by proprotein convertases. Antiviral Research. 99: 49-60. PMID 23611717 DOI: 10.1016/j.antiviral.2013.04.013  0.52
2013 Berthold HK, Seidah NG, Benjannet S, Gouni-Berthold I. Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels. Plos One. 8: e60095. PMID 23544125 DOI: 10.1371/journal.pone.0060095  0.52
2013 Burri DJ, da Palma JR, Seidah NG, Zanotti G, Cendron L, Pasquato A, Kunz S. Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P). Journal of Virology. 87: 6406-14. PMID 23536681 DOI: 10.1128/JVI.00072-13  0.52
2013 Guillemot J, Seidah NG. Reply: To PMID 23390091. Hepatology (Baltimore, Md.). 58: 1861-2. PMID 23505014 DOI: 10.1002/hep.26397  0.52
2013 Levy E, Ben Djoudi Ouadda A, Spahis S, Sane AT, Garofalo C, Grenier É, Emonnot L, Yara S, Couture P, Beaulieu JF, Ménard D, Seidah NG, Elchebly M. PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells. Atherosclerosis. 227: 297-306. PMID 23422832 DOI: 10.1016/j.atherosclerosis.2013.01.023  0.52
2013 Guillemot J, Canuel M, Essalmani R, Prat A, Seidah NG. Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin. Hepatology (Baltimore, Md.). 57: 2514-24. PMID 23390091 DOI: 10.1002/hep.26297  0.52
2013 Poirier S, Mayer G, Murphy SR, Garver WS, Chang TY, Schu P, Seidah NG. The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins. Traffic (Copenhagen, Denmark). 14: 458-69. PMID 23350547 DOI: 10.1111/tra.12046  0.52
2013 Seidah NG. Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors in the treatment of hypercholesterolemia and other pathologies. Current Pharmaceutical Design. 19: 3161-72. PMID 23317404 DOI: 10.2174/1381612811319170024  0.52
2013 Krastins B, Prakash A, Sarracino DA, Nedelkov D, Niederkofler EE, Kiernan UA, Nelson R, Vogelsang MS, Vadali G, Garces A, Sutton JN, Peterman S, Byram G, Darbouret B, Pérusse JR, ... Seidah NG, et al. Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum. Clinical Biochemistry. 46: 399-410. PMID 23313081 DOI: 10.1016/j.clinbiochem.2012.12.019  0.52
2013 Fantus D, Awan Z, Seidah NG, Genest J. Aortic calcification: Novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor. Atherosclerosis. 226: 9-15. PMID 23040868 DOI: 10.1016/j.atherosclerosis.2012.08.026  0.52
2013 Seidah NG. Proprotein Convertases SKI-1/S1P and PCSK9 Handbook of Biologically Active Peptides. 1821-1828. DOI: 10.1016/B978-0-12-385095-9.00249-9  0.52
2013 Seidah NG. Proprotein Convertases PC4, PACE4, and PC7 Handbook of Biologically Active Peptides. 1812-1820. DOI: 10.1016/B978-0-12-385095-9.00248-7  0.52
2013 Seidah NG. Proprotein Convertase Furin and Proprotein Convertase PC5/6 Handbook of Biologically Active Peptides. 1803-1811. DOI: 10.1016/B978-0-12-385095-9.00247-5  0.52
2013 Seidah NG. Proprotein Convertase PCSK9 Handbook of Proteolytic Enzymes. 3: 3315-3322. DOI: 10.1016/B978-0-12-382219-2.00732-8  0.52
2013 Seidah NG. Proprotein Convertase 7 Handbook of Proteolytic Enzymes. 3: 3310-3314. DOI: 10.1016/B978-0-12-382219-2.00731-6  0.52
2013 Seidah NG. Proprotein Convertase 5 Handbook of Proteolytic Enzymes. 3: 3305-3310. DOI: 10.1016/B978-0-12-382219-2.00730-4  0.52
2013 Seidah NG. Proprotein Convertase 4 Handbook of Proteolytic Enzymes. 3: 3295-3299. DOI: 10.1016/B978-0-12-382219-2.00728-6  0.52
2013 Seidah NG. Proprotein Convertase 2 Handbook of Proteolytic Enzymes. 3: 3290-3295. DOI: 10.1016/B978-0-12-382219-2.00727-4  0.52
2013 Seidah NG. Proprotein Convertase 1/3 Handbook of Proteolytic Enzymes. 3: 3286-3290. DOI: 10.1016/B978-0-12-382219-2.00726-2  0.52
2013 Seidah NG. Site-1 Protease Handbook of Proteolytic Enzymes. 3: 3265-3270. DOI: 10.1016/B978-0-12-382219-2.00721-3  0.52
2012 Sun X, Essalmani R, Day R, Khatib AM, Seidah NG, Prat A. Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver. Neoplasia (New York, N.Y.). 14: 1122-31. PMID 23308045 DOI: 10.1593/neo.121252  0.52
2012 Besnard J, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang XP, Norval S, Sassano MF, Shin AI, Webster LA, Simeons FR, Stojanovski L, Prat A, Seidah NG, Constam DB, et al. Automated design of ligands to polypharmacological profiles. Nature. 492: 215-20. PMID 23235874 DOI: 10.1038/nature11691  0.52
2012 Rousselet E, Kriz J, Seidah NG. Mouse model of intraluminal MCAO: cerebral infarct evaluation by cresyl violet staining. Journal of Visualized Experiments : Jove. PMID 23168377 DOI: 10.3791/4038  0.52
2012 Saavedra YG, Day R, Seidah NG. The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway. The Journal of Biological Chemistry. 287: 43492-501. PMID 23105118 DOI: 10.1074/jbc.M112.394023  0.52
2012 Maret D, Sadr MS, Sadr ES, Colman DR, Del Maestro RF, Seidah NG. Opposite roles of furin and PC5A in N-cadherin processing. Neoplasia (New York, N.Y.). 14: 880-92. PMID 23097623 DOI: 10.1593/neo.121250  0.52
2012 Benjannet S, Hamelin J, Chrétien M, Seidah NG. Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation. The Journal of Biological Chemistry. 287: 33745-55. PMID 22875854 DOI: 10.1074/jbc.M112.399725  0.52
2012 Seidah NG, Poirier S, Denis M, Parker R, Miao B, Mapelli C, Prat A, Wassef H, Davignon J, Hajjar KA, Mayer G. Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. Plos One. 7: e41865. PMID 22848640 DOI: 10.1371/journal.pone.0041865  0.52
2012 Kim W, Essalmani R, Szumska D, Creemers JW, Roebroek AJ, D'Orleans-Juste P, Bhattacharya S, Seidah NG, Prat A. Loss of endothelial furin leads to cardiac malformation and early postnatal death. Molecular and Cellular Biology. 32: 3382-91. PMID 22733989 DOI: 10.1128/MCB.06331-11  0.52
2012 Abifadel M, Guerin M, Benjannet S, Rabès JP, Le Goff W, Julia Z, Hamelin J, Carreau V, Varret M, Bruckert E, Tosolini L, Meilhac O, Couvert P, Bonnefont-Rousselot D, Chapman J, ... ... Seidah NG, et al. Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia. Atherosclerosis. 223: 394-400. PMID 22683120 DOI: 10.1016/j.atherosclerosis.2012.04.006  0.52
2012 Seidah NG, Prat A. The biology and therapeutic targeting of the proprotein convertases. Nature Reviews. Drug Discovery. 11: 367-83. PMID 22679642 DOI: 10.1038/nrd3699  0.52
2012 Blanchet M, Seidah NG, Labonté P. SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication. Antiviral Research. 95: 159-66. PMID 22626636 DOI: 10.1016/j.antiviral.2012.05.006  0.52
2012 Refaie S, Gagnon S, Gagnon H, Desjardins R, D'Anjou F, D'Orléans-Juste P, Zhu X, Steiner DF, Seidah NG, Lazure C, Salzet M, Day R. Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. The Journal of Biological Chemistry. 287: 14703-17. PMID 22396549 DOI: 10.1074/jbc.M111.323220  0.52
2012 Burri DJ, Pasqual G, Rochat C, Seidah NG, Pasquato A, Kunz S. Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease. Journal of Virology. 86: 4935-46. PMID 22357276 DOI: 10.1128/JVI.00024-12  0.52
2012 Tassew NG, Charish J, Seidah NG, Monnier PP. SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth. Developmental Cell. 22: 391-402. PMID 22340500 DOI: 10.1016/j.devcel.2011.11.022  0.52
2012 Denis M, Marcinkiewicz J, Zaid A, Gauthier D, Poirier S, Lazure C, Seidah NG, Prat A. Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. Circulation. 125: 894-901. PMID 22261195 DOI: 10.1161/CIRCULATIONAHA.111.057406  0.52
2012 Guillemot J, Thouënnon E, Guérin M, Vallet-Erdtmann V, Ravni A, Montéro-Hadjadje M, Lefebvre H, Klein M, Muresan M, Seidah NG, Anouar Y, Yon L. Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66. Journal of Molecular Endocrinology. 48: 115-27. PMID 22217803 DOI: 10.1530/JME-11-0077  0.52
2012 Awan Z, Seidah NG, MacFadyen JG, Benjannet S, Chasman DI, Ridker PM, Genest J. Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial. Clinical Chemistry. 58: 183-9. PMID 22065156 DOI: 10.1373/clinchem.2011.172932  0.52
2012 Richard C, Couture P, Desroches S, Benjannet S, Seidah NG, Lichtenstein AH, Lamarche B. Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome. The British Journal of Nutrition. 107: 705-11. PMID 21787450 DOI: 10.1017/S0007114511003436  0.52
2011 Awan Z, Denis M, Bailey D, Giaid A, Prat A, Goltzman D, Seidah NG, Genest J. The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography. Atherosclerosis. 219: 455-62. PMID 22051553 DOI: 10.1016/j.atherosclerosis.2011.08.035  0.52
2011 Prat A, Behrendt M, Marcinkiewicz E, Boridy S, Sairam RM, Seidah NG, Maysinger D. A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy. Journal of Aging Research. 2011: 251517. PMID 21969914 DOI: 10.4061/2011/251517  0.52
2011 Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M, Chrétien M. Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture. Clinical Chemistry. 57: 1415-23. PMID 21813713 DOI: 10.1373/clinchem.2011.165191  0.52
2011 Seidah NG. The proprotein convertases, 20 years later. Methods in Molecular Biology (Clifton, N.J.). 768: 23-57. PMID 21805237 DOI: 10.1007/978-1-61779-204-5_3  0.52
2011 Sun X, Essalmani R, Susan-Resiga D, Prat A, Seidah NG. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. The Journal of Biological Chemistry. 286: 29063-73. PMID 21700711 DOI: 10.1074/jbc.M111.242479  0.52
2011 Marchesi C, Essalmani R, Lemarié CA, Leibovitz E, Ebrahimian T, Paradis P, Seidah NG, Schiffrin EL, Prat A. Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. Journal of Molecular Medicine (Berlin, Germany). 89: 1103-11. PMID 21681612 DOI: 10.1007/s00109-011-0776-9  0.52
2011 Pasquato A, Burri DJ, Traba EG, Hanna-El-Daher L, Seidah NG, Kunz S. Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease. Virology. 417: 18-26. PMID 21612810 DOI: 10.1016/j.virol.2011.04.021  0.52
2011 Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Benjannet S, Chamberland A, Day R, Szumska D, Constam D, Bhattacharya S, Prat A, Seidah NG. Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. The Journal of Biological Chemistry. 286: 22785-94. PMID 21550985 DOI: 10.1074/jbc.M111.233577  0.52
2011 Rousselet E, Marcinkiewicz J, Kriz J, Zhou A, Hatten ME, Prat A, Seidah NG. PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke. Journal of Lipid Research. 52: 1383-91. PMID 21518694 DOI: 10.1194/jlr.M014118  0.52
2011 Seidah NG. What lies ahead for the proprotein convertases? Annals of the New York Academy of Sciences. 1220: 149-61. PMID 21388412 DOI: 10.1111/j.1749-6632.2010.05883.x  0.52
2011 Denis N, Palmer-Smith H, Elisma F, Busuttil A, Wright TG, Bou Khalil M, Prat A, Seidah NG, Chrétien M, Mayne J, Figeys D. Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells. Journal of Proteome Research. 10: 2011-26. PMID 21332221 DOI: 10.1021/pr2000072  0.52
2011 Roubtsova A, Munkonda MN, Awan Z, Marcinkiewicz J, Chamberland A, Lazure C, Cianflone K, Seidah NG, Prat A. Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 785-91. PMID 21273557 DOI: 10.1161/ATVBAHA.110.220988  0.52
2011 Rousselet E, Benjannet S, Marcinkiewicz E, Asselin MC, Lazure C, Seidah NG. Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. The Journal of Biological Chemistry. 286: 9185-95. PMID 21209099 DOI: 10.1074/jbc.M110.189936  0.52
2011 Essalmani R, Susan-Resiga D, Chamberland A, Abifadel M, Creemers JW, Boileau C, Seidah NG, Prat A. In vivo evidence that furin from hepatocytes inactivates PCSK9. The Journal of Biological Chemistry. 286: 4257-63. PMID 21147780 DOI: 10.1074/jbc.M110.192104  0.52
2011 Tremblay AJ, Lamarche B, Lemelin V, Hoos L, Benjannet S, Seidah NG, Davis HR, Couture P. Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men. Journal of Lipid Research. 52: 558-65. PMID 21123766 DOI: 10.1194/jlr.M011080  0.52
2011 Rousselet E, Benjannet S, Hamelin J, Canuel M, Seidah NG. The proprotein convertase PC7: unique zymogen activation and trafficking pathways. The Journal of Biological Chemistry. 286: 2728-38. PMID 21075846 DOI: 10.1074/jbc.M110.192344  0.52
2011 Gorski JP, Huffman NT, Chittur S, Midura RJ, Black C, Oxford J, Seidah NG. Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization. The Journal of Biological Chemistry. 286: 1836-49. PMID 21075843 DOI: 10.1074/jbc.M110.151647  0.52
2011 Mbikay M, Seidah NG. Preface Methods in Molecular Biology. 768.  0.52
2010 Maret D, Gruzglin E, Sadr MS, Siu V, Shan W, Koch AW, Seidah NG, Del Maestro RF, Colman DR. Surface expression of precursor N-cadherin promotes tumor cell invasion. Neoplasia (New York, N.Y.). 12: 1066-80. PMID 21170270 DOI: 10.1593/neo.10954  0.52
2010 Benjannet S, Saavedra YG, Hamelin J, Asselin MC, Essalmani R, Pasquato A, Lemaire P, Duke G, Miao B, Duclos F, Parker R, Mayer G, Seidah NG. Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events. The Journal of Biological Chemistry. 285: 40965-78. PMID 20937814 DOI: 10.1074/jbc.M110.154815  0.52
2010 Chitramuthu BP, Baranowski DC, Cadieux B, Rousselet E, Seidah NG, Bennett HP. Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 2933-46. PMID 20882679 DOI: 10.1002/dvdy.22426  0.52
2010 Khatib AM, Lahlil R, Scamuffa N, Akimenko MA, Ernest S, Lomri A, Lalou C, Seidah NG, Villoutreix BO, Calvo F, Siegfried G. Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration. Plos One. 5: e11438. PMID 20625388 DOI: 10.1371/journal.pone.0011438  0.52
2010 Davignon J, Dubuc G, Seidah NG. The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis. Current Atherosclerosis Reports. 12: 308-15. PMID 20623344 DOI: 10.1007/s11883-010-0123-6  0.52
2010 Gupta N, Fisker N, Asselin MC, Lindholm M, Rosenbohm C, Ørum H, Elmén J, Seidah NG, Straarup EM. A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo. Plos One. 5: e10682. PMID 20498851 DOI: 10.1371/journal.pone.0010682  0.52
2010 Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, LaFerla FM, Spencer TA, Hickey WF, Chang TY. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proceedings of the National Academy of Sciences of the United States of America. 107: 3081-6. PMID 20133765 DOI: 10.1073/pnas.0913828107  0.52
2010 Levy E, Lalonde G, Delvin E, Elchebly M, Précourt LP, Seidah NG, Spahis S, Rabasa-Lhoret R, Ziv E. Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus. Endocrinology. 151: 958-70. PMID 20130116 DOI: 10.1210/en.2009-0866  0.52
2010 Dong B, Wu M, Li H, Kraemer FB, Adeli K, Seidah NG, Park SW, Liu J. Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. Journal of Lipid Research. 51: 1486-95. PMID 20048381 DOI: 10.1194/jlr.M003566  0.52
2010 Mbikay M, Sirois F, Mayne J, Wang GS, Chen A, Dewpura T, Prat A, Seidah NG, Chretien M, Scott FW. PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. Febs Letters. 584: 701-6. PMID 20026049 DOI: 10.1016/j.febslet.2009.12.018  0.52
2010 Dubuc G, Tremblay M, Paré G, Jacques H, Hamelin J, Benjannet S, Boulet L, Genest J, Bernier L, Seidah NG, Davignon J. A new method for measurement of total plasma PCSK9: clinical applications. Journal of Lipid Research. 51: 140-9. PMID 19571328 DOI: 10.1194/jlr.M900273-JLR200  0.52
2010 Seidah NG. Neuroendocrine Peptide Processing Encyclopedia of Neuroscience. 343-350. DOI: 10.1016/B978-008045046-9.01195-5  0.52
2009 Iatan I, Dastani Z, Do R, Weissglas-Volkov D, Ruel I, Lee JC, Huertas-Vazquez A, Taskinen MR, Prat A, Seidah NG, Pajukanta P, Engert JC, Genest J. Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. Circulation. Cardiovascular Genetics. 2: 467-75. PMID 20031622 DOI: 10.1161/CIRCGENETICS.109.877811  0.52
2009 Sun X, Essalmani R, Seidah NG, Prat A. The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model. Molecular Cancer. 8: 73. PMID 19737405 DOI: 10.1186/1476-4598-8-73  0.52
2009 Poirier S, Mayer G, Poupon V, McPherson PS, Desjardins R, Ly K, Asselin MC, Day R, Duclos FJ, Witmer M, Parker R, Prat A, Seidah NG. Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. The Journal of Biological Chemistry. 284: 28856-64. PMID 19635789 DOI: 10.1074/jbc.M109.037085  0.52
2009 Labonté P, Begley S, Guévin C, Asselin MC, Nassoury N, Mayer G, Prat A, Seidah NG. PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression. Hepatology (Baltimore, Md.). 50: 17-24. PMID 19489072 DOI: 10.1002/hep.22911  0.52
2009 Leblond F, Seidah NG, Précourt LP, Delvin E, Dominguez M, Levy E. Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G805-15. PMID 19179626 DOI: 10.1152/ajpgi.90424.2008  0.52
2009 Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. The Journal of Biological Chemistry. 284: 3793-803. PMID 19074428 DOI: 10.1074/jbc.M808920200  0.52
2009 Seidah NG. PCSK9 as a therapeutic target of dyslipidemia. Expert Opinion On Therapeutic Targets. 13: 19-28. PMID 19063703 DOI: 10.1517/14728220802600715  0.52
2009 Gorski JP, Huffman NT, Cui C, Henderson EP, Midura RJ, Seidah NG. Potential role of proprotein convertase SKI-1 in the mineralization of primary bone. Cells, Tissues, Organs. 189: 25-32. PMID 18728345 DOI: 10.1159/000151723  0.52
2008 Mayer G, Poirier S, Seidah NG. Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. The Journal of Biological Chemistry. 283: 31791-801. PMID 18799458 DOI: 10.1074/jbc.M805971200  0.52
2008 Chrétien M, Seidah NG, Basak A, Mbikay M. Proprotein convertases as therapeutic targets. Expert Opinion On Therapeutic Targets. 12: 1289-300. PMID 18781827 DOI: 10.1517/14728222.12.10.1289  0.36
2008 Zaid A, Roubtsova A, Essalmani R, Marcinkiewicz J, Chamberland A, Hamelin J, Tremblay M, Jacques H, Jin W, Davignon J, Seidah NG, Prat A. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology (Baltimore, Md.). 48: 646-54. PMID 18666258 DOI: 10.1002/hep.22354  0.32
2008 Scamuffa N, Basak A, Lalou C, Wargnier A, Marcinkiewicz J, Siegfried G, Chrétien M, Calvo F, Seidah NG, Khatib AM. Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7 Gut. 57: 1573-1582. PMID 18664504 DOI: 10.1136/gut.2007.141812  0.52
2008 Ozden S, Lucas-Hourani M, Ceccaldi PE, Basak A, Valentine M, Benjannet S, Hamelin J, Jacob Y, Mamchaoui K, Mouly V, Desprès P, Gessain A, Butler-Browne G, Chrétien M, Tangy F, ... ... Seidah NG, et al. Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein. The Journal of Biological Chemistry. 283: 21899-908. PMID 18559340 DOI: 10.1074/jbc.M802444200  0.52
2008 Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J, Taylor JM, Schneider JE, Arnold SJ, Johnson P, Tymowska-Lalanne Z, ... ... Seidah NG, et al. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes & Development. 22: 1465-77. PMID 18519639 DOI: 10.1101/gad.479408  0.52
2008 Dewpura T, Raymond A, Hamelin J, Seidah NG, Mbikay M, Chrétien M, Mayne J. PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans. The Febs Journal. 275: 3480-93. PMID 18498363 DOI: 10.1111/j.1742-4658.2008.06495.x  0.52
2008 Essalmani R, Zaid A, Marcinkiewicz J, Chamberland A, Pasquato A, Seidah NG, Prat A. In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proceedings of the National Academy of Sciences of the United States of America. 105: 5750-5. PMID 18378898 DOI: 10.1073/pnas.0709428105  0.52
2008 Seidah NG, Mayer G, Zaid A, Rousselet E, Nassoury N, Poirier S, Essalmani R, Prat A. The activation and physiological functions of the proprotein convertases. The International Journal of Biochemistry & Cell Biology. 40: 1111-25. PMID 18343183 DOI: 10.1016/j.biocel.2008.01.030  0.52
2008 Pasquato A, Seidah NG. The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains. Journal of Molecular Neuroscience : Mn. 35: 339-43. PMID 18306058 DOI: 10.1007/s12031-008-9052-z  0.52
2008 Scamuffa N, Siegfried G, Bontemps Y, Ma L, Basak A, Cherel G, Calvo F, Seidah NG, Khatib AM. Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells. The Journal of Clinical Investigation. 118: 352-63. PMID 18064302 DOI: 10.1172/JCI32040  0.52
2008 Xiao Y, Chen G, Richard J, Rougeau N, Li H, Seidah NG, Cohen EA. Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases. Virology. 372: 384-97. PMID 18061232 DOI: 10.1016/j.virol.2007.10.036  0.52
2008 Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. The Journal of Biological Chemistry. 283: 2363-72. PMID 18039658 DOI: 10.1074/jbc.M708098200  0.52
2008 Mayer G, Hamelin J, Asselin MC, Pasquato A, Marcinkiewicz E, Tang M, Tabibzadeh S, Seidah NG. The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates. The Journal of Biological Chemistry. 283: 2373-84. PMID 18039650 DOI: 10.1074/jbc.M708763200  0.52
2007 Pasquato A, Dettin M, Basak A, Gambaretto R, Tonin L, Seidah NG, Di Bello C. Heparin enhances the furin cleavage of HIV-1 gp160 peptides Febs Letters. 581: 5807-5813. PMID 18037384 DOI: 10.1016/j.febslet.2007.11.050  0.52
2007 Lapierre M, Siegfried G, Scamuffa N, Bontemps Y, Calvo F, Seidah NG, Khatib AM. Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: Role of tissue inhibitors of metalloproteinase-1 Cancer Research. 67: 9030-9034. PMID 17909005 DOI: 10.1158/0008-5472.CAN-07-0807  0.52
2007 De Windt A, Rai M, Bernier L, Thelen K, Soini J, Lefebvre C, Chintawar S, Lavigne J, Saarinen L, Kytömäki L, Munzer JS, Lütjohann D, Pandolfo M, Davignon J, Seidah NG, et al. Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells. Dna and Cell Biology. 26: 765-72. PMID 17867930 DOI: 10.1089/dna.2007.0624  0.52
2007 Mayne J, Raymond A, Chaplin A, Cousins M, Kaefer N, Gyamera-Acheampong C, Seidah NG, Mbikay M, Chrétien M, Ooi TC. Plasma PCSK9 levels correlate with cholesterol in men but not in women. Biochemical and Biophysical Research Communications. 361: 451-6. PMID 17645871 DOI: 10.1016/j.bbrc.2007.07.029  0.52
2007 Dikeakos JD, Mercure C, Lacombe MJ, Seidah NG, Reudelhuber TL. PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism. The Febs Journal. 274: 4094-102. PMID 17645548 DOI: 10.1111/j.1742-4658.2007.05937.x  0.52
2007 Pullikotil P, Benjannet S, Mayne J, Seidah NG. The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization. The Journal of Biological Chemistry. 282: 27402-13. PMID 17623657 DOI: 10.1074/jbc.M703200200  0.52
2007 Billova S, Galanopoulou AS, Seidah NG, Qiu X, Kumar U. Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain Neuroscience. 147: 403-418. PMID 17543468 DOI: 10.1016/j.neuroscience.2007.04.039  0.52
2007 Mbikay M, Mayne J, Seidah NG, Chrétien M. Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms. Medical Hypotheses. 69: 1010-7. PMID 17502126 DOI: 10.1016/j.mehy.2007.03.018  0.52
2007 Mbikay M, Croissandeau G, Sirois F, Anini Y, Mayne J, Seidah NG, Chrétien M. A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat. Developmental Biology. 306: 584-98. PMID 17490633 DOI: 10.1016/j.ydbio.2007.03.523  0.52
2007 Nassoury N, Blasiole DA, Tebon Oler A, Benjannet S, Hamelin J, Poupon V, McPherson PS, Attie AD, Prat A, Seidah NG. The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR. Traffic (Copenhagen, Denmark). 8: 718-32. PMID 17461796 DOI: 10.1111/j.1600-0854.2007.00562.x  0.32
2007 Seidah NG, Prat A. The proprotein convertases are potential targets in the treatment of dyslipidemia Journal of Molecular Medicine. 85: 685-696. PMID 17351764 DOI: 10.1007/s00109-007-0172-7  0.52
2007 Goodridge JP, Lathbury LJ, Steiner NK, Shulse CN, Pullikotil P, Seidah NG, Hurley CK, Christiansen FT, Witt CS. Three common alleles of KIR2DL4 (CD158d) encode constitutively expressed, inducible and secreted receptors in NK cells. European Journal of Immunology. 37: 199-211. PMID 17171757 DOI: 10.1002/eji.200636316  0.52
2007 Tremblay LO, Nagy Kovács E, Daniels E, Wong NK, Sutton-Smith M, Morris HR, Dell A, Marcinkiewicz E, Seidah NG, McKerlie C, Herscovics A. Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation. The Journal of Biological Chemistry. 282: 2558-66. PMID 17121831 DOI: 10.1074/jbc.M608661200  0.52
2007 Yakovleva T, Marinova Z, Kuzmin A, Seidah NG, Haroutunian V, Terenius L, Bakalkin G. Dysregulation of dynorphins in Alzheimer disease. Neurobiology of Aging. 28: 1700-8. PMID 16914231 DOI: 10.1016/j.neurobiolaging.2006.07.002  0.52
2006 Scamuffa N, Calvo F, Chrétien M, Seidah NG, Khatib AM. Proprotein convertases: Lessons from knockouts Faseb Journal. 20: 1954-1963. PMID 17012247 DOI: 10.1096/fj.05-5491rev  0.52
2006 Seidah NG, Khatib AM, Prat A. The proprotein convertases and their implication in sterol and/or lipid metabolism Biological Chemistry. 387: 871-877. PMID 16913836 DOI: 10.1515/BC.2006.110  0.52
2006 Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: Functional consequences of natural mutations and post-translational modifications Journal of Biological Chemistry. 281: 30561-30572. PMID 16912035 DOI: 10.1074/jbc.M606495200  0.52
2006 Croissandeau G, Wahnon F, Yashpal K, Seidah NG, Coderre TJ, Chrétien M, Mbikay M. Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2. Neuroscience Letters. 406: 71-5. PMID 16905251 DOI: 10.1016/j.neulet.2006.07.031  0.52
2006 Poirier S, Prat A, Marcinkiewicz E, Paquin J, Chitramuthu BP, Baranowski D, Cadieux B, Bennett HPJ, Seidah NG. Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system Journal of Neurochemistry. 98: 838-850. PMID 16893422 DOI: 10.1111/j.1471-4159.2006.03928.x  0.52
2006 Pasquato A, Pullikotil P, Asselin MC, Vacatello M, Paolillo L, Ghezzo F, Basso F, Di Bello C, Dettin M, Seidah NG. The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors. The Journal of Biological Chemistry. 281: 23471-81. PMID 16790437 DOI: 10.1074/jbc.M513675200  0.52
2006 Seidah NG. Unexpected similarity between the cytosolic West Nile virus NS3 and the secretory furin-like serine proteinases The Biochemical Journal. 393. PMID 16371006  0.52
2006 Essalmani R, Hamelin J, Marcinkiewicz J, Chamberland A, Mbikay M, Chrétien M, Seidah NG, Prat A. Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse Molecular and Cellular Biology. 26: 354-361. PMID 16354705 DOI: 10.1128/MCB.26.1.354-361.2006  0.52
2006 Basak A, Banik UK, Basak S, Seidah NG, Li S. Evaluation of anti-proprotein convertase activity of diterpene andrographolid derived products Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (Pcs): a New Potential Strategy in Cancer Therapy. 137-154. DOI: 10.1007/1-4020-5132-8_8  0.52
2006 Khatib AM, Scamuffa N, Calvo F, Chrètien M, Seidah NG. Discovery of the proprotein convertases and their inhibitors Regulation of Carcinogenesis, Angiogenesis and Metastasis by the Proprotein Convertases (Pcs): a New Potential Strategy in Cancer Therapy. 7-26. DOI: 10.1007/1-4020-5132-8_1  0.52
2005 Salvas A, Benjannet S, Reudelhuber TL, Chrétien M, Seidah NG. Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi. Febs Letters. 579: 5621-5. PMID 16213495 DOI: 10.1016/j.febslet.2005.09.029  0.52
2005 Nour N, Mayer G, Mort JS, Salvas A, Mbikay M, Morrison CJ, Overall CM, Seidah NG. The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases Molecular Biology of the Cell. 16: 5215-5226. PMID 16135528 DOI: 10.1091/mbc.E05-06-0504  0.52
2005 Vincent MJ, Bergeron E, Benjannet S, Erickson BR, Rollin PE, Ksiazek TG, Seidah NG, Nichol ST. Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virology Journal. 2: 69. PMID 16115318 DOI: 10.1186/1743-422X-2-69  0.52
2005 Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ. Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. The Journal of Biological Chemistry. 280: 36551-9. PMID 16109723 DOI: 10.1074/jbc.M502264200  0.52
2005 Stawowy P, Meyborg H, Stibenz D, Stawowy NBP, Roser M, Thanabalasingam U, Veinot JP, Chrétien M, Seidah NG, Fleck E, Graf K. Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis Circulation. 111: 2820-2827. PMID 15911696 DOI: 10.1161/CIRCULATIONAHA.104.502617  0.52
2005 De Cicco RL, Bassi DE, Zucker S, Seidah NG, Klein-Szanto AJP. Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin Cancer Research. 65: 4162-4171. PMID 15899807 DOI: 10.1158/0008-5472.CAN-04-2820  0.52
2005 Stawowy P, Kallisch H, Borges Pereira Stawowy N, Stibenz D, Veinot JP, Gräfe M, Seidah NG, Chrétien M, Fleck E, Graf K. Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis. Virchows Archiv : An International Journal of Pathology. 446: 351-9. PMID 15756593 DOI: 10.1007/s00428-004-1198-7  0.52
2005 Lalanne F, Lambert G, Amar MJA, Chétiveaux M, Zaïr Y, Jarnoux AL, Ouguerram K, Friburg J, Seidah NG, Brewer HB, Krempf M, Costet P. Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells Journal of Lipid Research. 46: 1312-1319. PMID 15741654 DOI: 10.1194/jlr.M400396-JLR200  0.52
2005 Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG. β-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: Binding partners processed by furin Journal of Neurochemistry. 92: 93-102. PMID 15606899 DOI: 10.1111/j.1471-4159.2004.02840.x  0.52
2005 Bergeron E, Vincent MJ, Wickham L, Hamelin J, Basak A, Nichol ST, Chrétien M, Seidah NG. Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus. Biochemical and Biophysical Research Communications. 326: 554-63. PMID 15596135 DOI: 10.1016/j.bbrc.2004.11.063  0.52
2004 Benjannet S, Cromlish JA, Diallo K, Chrétien M, Seidah NG. The metabolism of β-amyloid converting enzyme and β-amyloid precursor protein processing Biochemical and Biophysical Research Communications. 325: 235-242. PMID 15522224 DOI: 10.1016/j.bbrc.2004.10.019  0.52
2004 Amiri F, Virdis A, Neves MF, Iglarz M, Seidah NG, Touyz RM, Reudelhuber TL, Schiffrin EL. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation. 110: 2233-40. PMID 15466627 DOI: 10.1161/01.CIR.0000144462.08345.B9  0.52
2004 Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, ... ... Seidah NG, et al. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. The Journal of Biological Chemistry. 279: 48865-75. PMID 15358785 DOI: 10.1074/jbc.M409699200  0.36
2004 Veinot JP, Prichett-Pejic W, Picard P, Parks W, Schwartz R, Seidah NG, Chretien M. Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model Cardiovascular Pathology. 13: 241-250. PMID 15358338 DOI: 10.1016/j.carpath.2004.05.004  0.52
2004 Stawowy P, Kallisch H, Kilimnik A, Margeta C, Seidah NG, Chrétien M, Fleck E, Graf K. Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor Biochemical and Biophysical Research Communications. 321: 531-538. PMID 15358140 DOI: 10.1016/j.bbrc.2004.07.001  0.52
2004 Stawowy P, Margeta C, Kallisch H, Seidah NG, Chrétien M, Fleck E, Graf K. Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-β1 involves furin-convertase Cardiovascular Research. 63: 87-97. PMID 15194465 DOI: 10.1016/j.cardiores.2004.03.010  0.52
2004 Dubuc G, Chamberland A, Wassef H, Davignon J, Seidah NG, Bernier L, Prat A. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1454-9. PMID 15178557 DOI: 10.1161/01.ATV.0000134621.14315.43  0.52
2004 Mouchantaf R, Watt HL, Sulea T, Seidah NG, Alturaihi H, Patel YC, Kumar U. Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1 Regulatory Peptides. 120: 133-140. PMID 15177931 DOI: 10.1016/j.regpep.2004.02.022  0.52
2004 Nejjari M, Berthet V, Rigot V, Laforest S, Jacquier MF, Seidah NG, Remy L, Bruyneel E, Scoazec JY, Marvaldi J, Luis J. Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model American Journal of Pathology. 164: 1925-1933. PMID 15161629  0.52
2004 Posner SF, Vaslet CA, Jurofcik M, Lee A, Seidah NG, Nillni EA. Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1. Endocrine. 23: 199-213. PMID 15146101 DOI: 10.1385/ENDO:23:2-3:199  0.52
2004 Pullikotil P, Vincent M, Nichol ST, Seidah NG. Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: Processing of SREBP-2, ATF6, and a viral glycoprotein Journal of Biological Chemistry. 279: 17338-17347. PMID 14970232 DOI: 10.1074/jbc.M313764200  0.52
2004 Stawowy P, Kallisch H, Veinot JP, Kilimnik A, Prichett W, Goetze S, Seidah NG, Chrétien M, Fleck E, Graf K. Endoproteolytic Activation of αv Integrin by Proprotein Convertase PC5 Is Required for Vascular Smooth Muscle Cell Adhesion to Vitronectin and Integrin-Dependent Signaling Circulation. 109: 770-776. PMID 14970114 DOI: 10.1161/01.CIR.0000112583.50762.DE  0.52
2003 Winsky-Sommerer R, Grouselle D, Rougeot C, Laurent V, David JP, Delacourte A, Dournaud P, Seidah NG, Lindberg I, Trottier S, Epelbaum J. The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease. Neuroscience. 122: 437-47. PMID 14614908 DOI: 10.1016/S0306-4522(03)00560-8  0.52
2003 Hibbert AP, Morris SJ, Seidah NG, Murphy RA. Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathway. The Journal of Biological Chemistry. 278: 48129-36. PMID 12970359 DOI: 10.1074/jbc.M300961200  0.52
2003 Vincent MJ, Sanchez AJ, Erickson BR, Basak A, Chretien M, Seidah NG, Nichol ST. Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. Journal of Virology. 77: 8640-9. PMID 12885882 DOI: 10.1128/JVI.77.16.8640-8649.2003  0.52
2003 Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, Chrétien M, Seidah NG, Khatib AM. The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis Journal of Clinical Investigation. 111: 1723-1732. PMID 12782675  0.52
2003 Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M, Mori K. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. The Journal of Biological Chemistry. 278: 31024-32. PMID 12782636 DOI: 10.1074/jbc.M300923200  0.52
2003 Abifadel M, Varret M, Rabès JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, Derré A, Villéger L, Farnier M, Beucler I, Bruckert E, ... ... Seidah NG, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia Nature Genetics. 34: 154-156. PMID 12730697 DOI: 10.1038/ng1161  0.52
2003 Bergeron E, Basak A, Decroly E, Seidah NG. Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage. The Biochemical Journal. 373: 475-84. PMID 12691605 DOI: 10.1042/BJ20021630  0.52
2003 Siegfried G, Khatib AM, Benjannet S, Chrétien M, Seidah NG. The proteolytic processing of pro-platelet-derived growth factor-a at RRKR86 by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity Cancer Research. 63: 1458-1463. PMID 12670890  0.52
2003 Doblinger A, Becker A, Seidah NG, Laslop A. Proteolytic processing of chromogranin A by the prohormone convertase PC2 Regulatory Peptides. 111: 111-116. PMID 12609757 DOI: 10.1016/S0167-0115(02)00262-8  0.52
2003 Kalus I, Schnegelsberg B, Seidah NG, Kleene R, Schachner M. The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1 Journal of Biological Chemistry. 278: 10381-10388. PMID 12529374 DOI: 10.1074/jbc.M208351200  0.52
2003 Conesa M, Prat A, Mort JS, Marvaldi J, Lissitzky JC, Seidah NG. Down-regulation of αv/β3 integrin via misrouting to lysosomes by overexpression of a β3Lamp1 fusion protein Biochemical Journal. 370: 703-711. PMID 12444923 DOI: 10.1042/BJ20021301  0.52
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