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Nabil G. Seidah - Publications

Affiliations: 
Biochemistry Université de Montréal, Montréal, Canada 
Area:
Biochemistry, Medicine and Surgery
Website:
https://en.wikipedia.org/wiki/Nabil_Seidah
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Year Citation  Score
2020 Duval S, Abu-Thuraia A, Elkholi IE, Chen R, Seebun D, Mayne J, Côté JF, Figeys D, Seidah NG. Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression. Cell Death & Disease. 11: 665. PMID 32820145 DOI: 10.1038/S41419-020-02893-0  0.328
2020 Gan ES, Tan HC, Duyen HLT, Trieu HT, Wills B, Ooi EE, Seidah NG, Yacoub S. Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes. The Journal of Clinical Investigation. PMID 32644974 DOI: 10.1172/Jci137536  0.335
2020 Löw K, Ducrest AL, San-Jose LM, Simon C, Uva V, Seidah NG, Pasquato A, Kunz S, Roulin A. Molecular evolution of the proopiomelanocortin system in Barn owl species. Plos One. 15: e0231163. PMID 32369484 DOI: 10.1371/Journal.Pone.0231163  0.302
2020 Ashraf Y, Duval S, Sachan V, Essalmani R, Susan-Resiga D, Roubtsova A, Hamelin J, Gerhardy S, Kirchhofer D, Tagliabracci VS, Prat A, Kiss RS, Seidah NG. Proprotein Convertase 7 (PCSK7) Reduces apoA-V Levels. The Febs Journal. PMID 31945259 DOI: 10.1111/Febs.15212  0.353
2020 Durand L, Duval S, Evagelidis A, Guillemot J, Dianati V, Sikorska E, Schu P, Day R, Seidah NG. The motif ExExxxL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity. The Journal of Biological Chemistry. PMID 31915245 DOI: 10.1074/Jbc.Ra119.011775  0.353
2019 Ben Djoudi Ouadda A, Gauthier MS, Susan-Resiga D, Girard E, Essalmani R, Black M, Marcinkiewicz J, Forget D, Hamelin J, Evagelidis A, Ly K, Day R, Galarneau L, Corbin F, Coulombe B, ... ... Seidah NG, et al. Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor). Arteriosclerosis, Thrombosis, and Vascular Biology. 39: 1996-2013. PMID 31553664 DOI: 10.1161/Atvbaha.119.313247  0.353
2019 Mikaeeli S, Susan-Resiga D, Girard E, Ben Djoudi Ouadda A, Day R, Prost S, Seidah NG. Functional analysis of natural PCSK9 mutants in modern and archaic humans. The Febs Journal. PMID 31386798 DOI: 10.1111/Febs.15036  0.311
2019 Löw K, Hardes K, Fedeli C, Seidah NG, Constam DB, Pasquato A, Steinmetzer T, Roulin A, Kunz S. A novel cell-based sensor detecting the activity of individual basic proprotein convertases. The Febs Journal. PMID 31276291 DOI: 10.1111/Febs.14979  0.315
2019 Lebeau PF, Byun JH, Platko K, MacDonald ME, Poon SV, Faiyaz M, Seidah NG, Austin RC. Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice. The Journal of Biological Chemistry. PMID 31004037 DOI: 10.1074/Jbc.Ra119.008094  0.321
2019 Sachan V, Lodge R, Mihara K, Hamelin J, Power C, Gelman BB, Hollenberg MD, Cohen ÉA, Seidah NG. HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin. Cell Death and Differentiation. PMID 30683917 DOI: 10.1038/S41418-018-0264-7  0.321
2019 Seidah NG, Prat A, Pirillo A, Catapano AL, Norata GD. Novel strategies to target PCSK9: beyond monoclonal antibodies. Cardiovascular Research. PMID 30629143 DOI: 10.1093/Cvr/Cvz003  0.324
2018 Essalmani R, Weider E, Marcinkiewicz J, Chamberland A, Susan-Resig D, Roubtsova A, Seidah NG, Prat A. A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice. Biological Chemistry. PMID 30044755 DOI: 10.1515/Hsz-2018-0194  0.336
2018 Grin PM, Dwivedi DJ, Chathely KM, Trigatti BL, Prat A, Seidah NG, Liaw PC, Fox-Robichaud AE. Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor. Scientific Reports. 8: 10496. PMID 30002483 DOI: 10.1038/S41598-018-28777-0  0.333
2018 Gauthier MS, Awan Z, Bouchard A, Champagne J, Tessier S, Faubert D, Chabot K, Garneau PY, Rabasa-Lhoret R, Seidah NG, Ridker PM, Genest J, Coulombe B. Posttranslational modification of proprotein convertase subtilisin/kexin type 9 is differentially regulated in response to distinct cardiometabolic treatments as revealed by targeted proteomics. Journal of Clinical Lipidology. PMID 29699916 DOI: 10.1016/J.Jacl.2018.03.092  0.591
2018 Lebeau P, Platko K, Al-Hashimi AA, Byun JH, Lhoták Š, Holzapfel N, Gyulay G, Igdoura SA, Cool D, Trigatti B, Seidah NG, Austin RC. Loss-of-function PCSK9 mutants evade the unfolded protein response sensor, GRP78, and fail to induce endoplasmic reticulum stress when retained. The Journal of Biological Chemistry. PMID 29593095 DOI: 10.1016/J.Atherosclerosissup.2018.04.426  0.31
2018 Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, et al. Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. The Journal of Biological Chemistry. PMID 29559555 DOI: 10.1074/Jbc.M117.817981  0.315
2017 Hoac B, Susan-Resiga D, Essalmani R, Marcinkiweicz E, Seidah NG, McKee MD. Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone. Bone. PMID 29126984 DOI: 10.1016/J.Bone.2017.11.002  0.322
2017 Essalmani R, Susan-Resiga D, Guillemot J, Kim W, Sachan V, Awan Z, Chamberland A, Asselin MC, Ly K, Desjardins R, Day R, Prat A, Seidah NG. Thrombin activation of protein C requires prior processing by a liver proprotein convertase. The Journal of Biological Chemistry. 292: 13565. PMID 28821605 DOI: 10.1074/jbc.A116.77040  0.48
2017 Romagnuolo R, Scipione CA, Marcovina SM, Gemin M, Seidah NG, Boffa MB, Koschinsky ML. Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9. Plos One. 12: e0180869. PMID 28750079 DOI: 10.1371/Journal.Pone.0180869  0.317
2017 Paquette M, Luna Saavedra YG, Chamberland A, Prat A, Christensen DL, Lajeunesse-Trempe F, Kaduka L, Seidah NG, Dufour R, Baass A. Association Between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population. Metabolic Syndrome and Related Disorders. PMID 28749722 DOI: 10.1089/met.2017.0027  0.724
2017 Essalmani R, Susan-Resiga D, Guillemot J, WooJin K, Sachan V, Awan Z, Chamberland A, Asselin MC, Ly K, Desjardins R, Day R, Prat A, Seidah NG. Thrombin Activation of Protein C Requires Prior Processing by a Liver Proprotein Convertase. The Journal of Biological Chemistry. PMID 28468828 DOI: 10.1074/Jbc.M116.770040  0.578
2016 Susan-Resiga D, Girard E, Kiss RS, Essalmani R, Hamelin J, Asselin MC, Awan Z, Butkinaree C, Fleury A, Soldera A, Dory YL, Baass A, Seidah NG. A novel mechanism causing familial hypercholesterolemia: The proprotein convertase subtilisin/kexin type 9-resistant Arg410Ser LDL receptor mutation. The Journal of Biological Chemistry. PMID 27998977 DOI: 10.1074/Jbc.M116.769430  0.581
2016 Lebeau P, Al-Hashimi A, Sood S, Lhotak S, Yu P, Gyulay G, Pare G, Chen SR, Trigatti B, Pratt A, Seidah N, Austin RC. Endoplasmic reticulum stress and Ca2+ depletion differentially modulate the sterol-regulatory protein PCSK9 to control lipid metabolism. The Journal of Biological Chemistry. PMID 27909053 DOI: 10.1074/Jbc.M116.744235  0.339
2016 Ly K, Essalmani R, Desjardins R, Seidah NG, Day R. An Unbiased Mass Spectrometry Approach Identifies Glypican-3 as an Interactor of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and LDL Receptor in Hepatocellular Carcinoma Cells. The Journal of Biological Chemistry. PMID 27758865 DOI: 10.1074/Jbc.M116.746883  0.351
2016 Dwivedi DJ, Grin PM, Khan M, Prat A, Zhou J, Fox-Robichaud AE, Seidah NG, Liaw PC. Differential Expression of PCSK9 Modulates Infection, Inflammation and Coagulation in a Murine Model of Sepsis. Shock (Augusta, Ga.). PMID 27405064 DOI: 10.1097/Shk.0000000000000682  0.31
2016 Weider E, Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Ashraf Y, Wycoff KL, Zhang J, Prat A, Seidah NG. Proprotein convertase subtilisin/Kexin type 9 (PCSK9) single domain antibodies are potent inhibitors of LDL receptor degradation. The Journal of Biological Chemistry. PMID 27284008 DOI: 10.1074/Jbc.M116.717736  0.339
2016 Seidah NG. New developments in proprotein convertase subtilisin-kexin 9's biology and clinical implications. Current Opinion in Lipidology. PMID 27031271 DOI: 10.1097/Mol.0000000000000295  0.334
2016 Awan Z, Denis M, Roubtsova A, Essalmani R, Marcinkiewicz J, Awan A, Gram H, Seidah NG, Genest J. Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia. Angiology. 67: 157-67. PMID 25904765 DOI: 10.1177/0003319715583205  0.545
2016 Da Palma JR, Cendron L, Seidah NG, Pasquato A, Kunz S. Mechanism of folding and activation of subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P) Journal of Biological Chemistry. 291: 2055-2066. DOI: 10.1074/Jbc.M115.677757  0.317
2015 Bhat M, Skill N, Marcus V, Deschenes M, Tan X, Bouteaud J, Negi S, Awan Z, Aikin R, Kwan J, Amre R, Tabaries S, Hassanain M, Seidah NG, Maluccio M, et al. Decreased PCSK9 expression in human hepatocellular carcinoma. Bmc Gastroenterology. 15: 176. PMID 26674961 DOI: 10.1186/S12876-015-0371-6  0.537
2015 Pandruvada SN, Beauregard J, Benjannet S, Pata M, Lazure C, Seidah NG, Vacher J. Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking. Molecular and Cellular Biology. 36: 507-21. PMID 26598607 DOI: 10.1128/Mcb.00656-15  0.32
2015 Armstrong SM, Sugiyama MG, Fung KY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu SN, Neculai D, Yin C, Bolz SS, Seidah NG, Cybulsky MI, Heit B, et al. A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. Cardiovascular Research. PMID 26334034 DOI: 10.1093/Cvr/Cvv218  0.313
2015 Roubtsova A, Chamberland A, Marcinkiewicz J, Essalmani R, Fazel A, Bergeron JJ, Seidah NG, Prat A. PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice. Journal of Lipid Research. 56: 2133-42. PMID 26323289 DOI: 10.1194/Jlr.M061952  0.313
2015 Kim W, Zekas E, Lodge R, Susan-Resiga D, Marcinkiewicz E, Essalmani R, Mihara K, Ramachandran R, Asahchop E, Gelman B, Cohen ÉA, Power C, Hollenberg MD, Seidah NG. Neuroinflammation-induced interactions between protease-activated receptor 1 and proprotein convertases in HIV-associated neurocognitive disorder. Molecular and Cellular Biology. PMID 26283733 DOI: 10.1128/Mcb.00764-15  0.309
2015 Le QT, Blanchet M, Seidah NG, Labonté P. Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9. The Journal of Biological Chemistry. 290: 23385-400. PMID 26195630 DOI: 10.1074/Jbc.M115.642991  0.317
2015 Butkinaree C, Canuel M, Essalmani R, Poirier S, Benjannet S, Asselin MC, Roubtsova A, Hamelin J, Marcinkiewicz J, Chamberland A, Guillemot J, Mayer G, Sisodia SS, Jacob Y, Prat A, ... Seidah NG, et al. Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other. The Journal of Biological Chemistry. 290: 18609-20. PMID 26085104 DOI: 10.1074/Jbc.M115.647180  0.628
2015 Bamimore MA, Zaid A, Banerjee Y, Al-Sarraf A, Abifadel M, Seidah NG, Al-Waili K, Al-Rasadi K, Awan Z. Familial hypercholesterolemia mutations in the Middle Eastern and North African region: a need for a national registry. Journal of Clinical Lipidology. 9: 187-94. PMID 25911074 DOI: 10.1016/J.Jacl.2014.11.008  0.511
2015 Romagnuolo R, Scipione CA, Boffa MB, Marcovina SM, Seidah NG, Koschinsky ML. Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor. The Journal of Biological Chemistry. 290: 11649-62. PMID 25778403 DOI: 10.1074/Jbc.M114.611988  0.301
2015 Gauthier MS, Pérusse JR, Awan Z, Bouchard A, Tessier S, Champagne J, Krastins B, Byram G, Chabot K, Garneau P, Rabasa-Lhoret R, Faubert D, Lopez MF, Seidah NG, Coulombe B. A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA-SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts. Methods (San Diego, Calif.). 81: 66-73. PMID 25770357 DOI: 10.1016/J.Ymeth.2015.03.003  0.587
2015 Dong B, Singh AB, Azhar S, Seidah NG, Liu J. High-fructose feeding promotes accelerated degradation of hepatic LDL receptor and hypercholesterolemia in hamsters via elevated circulating PCSK9 levels. Atherosclerosis. 239: 364-74. PMID 25682035 DOI: 10.1016/J.Atherosclerosis.2015.01.013  0.312
2014 da Palma JR, Burri DJ, Oppliger J, Salamina M, Cendron L, de Laureto PP, Seidah NG, Kunz S, Pasquato A. Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease. The Journal of Biological Chemistry. 289: 35743-56. PMID 25378398 DOI: 10.1074/Jbc.M114.588525  0.308
2014 Guillemot J, Essalmani R, Hamelin J, Seidah NG. Is there a link between proprotein convertase PC7 activity and human lipid homeostasis? Febs Open Bio. 4: 741-5. PMID 25349778 DOI: 10.1016/J.Fob.2014.08.004  0.364
2014 Duell PB, Dubuc G, Seidah NG, Davignon J. Clearance of plasma proprotein convertase subtilisin/kexin 9 by low-density lipoprotein apheresis. Circulation Research. 115: e3-4. PMID 24951769 DOI: 10.1161/Circresaha.114.304163  0.324
2014 Ly K, Saavedra YG, Canuel M, Routhier S, Desjardins R, Hamelin J, Mayne J, Lazure C, Seidah NG, Day R. Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9. The Journal of Biological Chemistry. 289: 17732-46. PMID 24808179 DOI: 10.1074/Jbc.M113.541094  0.343
2014 Pedersen NB, Wang S, Narimatsu Y, Yang Z, Halim A, Schjoldager KTBG, Madsen TD, Seidah NG, Bennett EP, Levery SB, Clausen H. Low density lipoprotein receptor class A repeats are O-glycosylated in linker regions Journal of Biological Chemistry. 289: 17312-17324. PMID 24798328 DOI: 10.1074/Jbc.M113.545053  0.31
2014 Awan Z, Dubuc G, Faraj M, Dufour R, Seidah NG, Davignon J, Rabasa-Lhoret R, Baass A. The effect of insulin on circulating PCSK9 in postmenopausal obese women. Clinical Biochemistry. 47: 1033-9. PMID 24721682 DOI: 10.1016/J.Clinbiochem.2014.03.022  0.565
2014 Seidah NG, Awan Z, Chrétien M, Mbikay M. PCSK9: a key modulator of cardiovascular health. Circulation Research. 114: 1022-36. PMID 24625727 DOI: 10.1161/Circresaha.114.301621  0.541
2014 Harihar S, Pounds KM, Iwakuma T, Seidah NG, Welch DR. Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing. Plos One. 9: e84958. PMID 24454770 DOI: 10.1371/Journal.Pone.0084958  0.336
2014 Harihar S, Hampton KR, Iwakuma T, Seidah NG, Welch DR. Abstract 135: Phosphorylation and furin-mediated processing are critical posttranslational modifications of the KISS1 metastasis suppressor Cancer Research. 74: 135-135. DOI: 10.1158/1538-7445.Am2014-135  0.336
2014 Awan Z, Dubuc G, Faraj M, Dufour R, Seidah N, Davignon J, Rabasa-Lhoret R, Baass A. Insulin Infusion Acutely Downregulates Circulating PCSK9 in Human* Journal of Clinical Lipidology. 8: 302. DOI: 10.1016/J.Jacl.2014.02.022  0.504
2013 Awan Z, Choi HY, Stitziel N, Ruel I, Bamimore MA, Husa R, Gagnon MH, Wang RH, Peloso GM, Hegele RA, Seidah NG, Kathiresan S, Genest J. APOE p.Leu167del mutation in familial hypercholesterolemia. Atherosclerosis. 231: 218-22. PMID 24267230 DOI: 10.1016/J.Cjca.2013.07.652  0.545
2013 Wetsel WC, Rodriguiz RM, Guillemot J, Rousselet E, Essalmani R, Kim IH, Bryant JC, Marcinkiewicz J, Desjardins R, Day R, Constam DB, Prat A, Seidah NG. Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 17362-7. PMID 24101515 DOI: 10.1073/Pnas.1314698110  0.314
2013 Saavedra YG, Zhang J, Seidah NG. PCSK9 prosegment chimera as novel inhibitors of LDLR degradation. Plos One. 8: e72113. PMID 23951290 DOI: 10.1371/Journal.Pone.0072113  0.388
2013 Essalmani R, Susan-Resiga D, Chamberland A, Asselin MC, Canuel M, Constam D, Creemers JW, Day R, Gauthier D, Prat A, Seidah NG. Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. The Journal of Biological Chemistry. 288: 26410-8. PMID 23918928 DOI: 10.1074/Jbc.M113.501304  0.382
2013 Seidah NG, Sadr MS, Chrétien M, Mbikay M. The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. The Journal of Biological Chemistry. 288: 21473-81. PMID 23775089 DOI: 10.1074/Jbc.R113.481549  0.356
2013 Awan Z, Delvin EE, Levy E, Genest J, Davignon J, Seidah NG, Baass A. Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype. The Canadian Journal of Cardiology. 29: 927-33. PMID 23743349 DOI: 10.1016/J.Cjca.2013.03.004  0.544
2013 Canuel M, Sun X, Asselin MC, Paramithiotis E, Prat A, Seidah NG. Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1). Plos One. 8: e64145. PMID 23675525 DOI: 10.1371/Journal.Pone.0064145  0.37
2013 Berthold HK, Seidah NG, Benjannet S, Gouni-Berthold I. Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels. Plos One. 8: e60095. PMID 23544125 DOI: 10.1371/Journal.Pone.0060095  0.341
2013 Levy E, Ben Djoudi Ouadda A, Spahis S, Sane AT, Garofalo C, Grenier É, Emonnot L, Yara S, Couture P, Beaulieu JF, Ménard D, Seidah NG, Elchebly M. PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells. Atherosclerosis. 227: 297-306. PMID 23422832 DOI: 10.1016/J.Atherosclerosis.2013.01.023  0.339
2013 Guillemot J, Canuel M, Essalmani R, Prat A, Seidah NG. Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin. Hepatology (Baltimore, Md.). 57: 2514-24. PMID 23390091 DOI: 10.1002/Hep.26297  0.34
2013 Poirier S, Mayer G, Murphy SR, Garver WS, Chang TY, Schu P, Seidah NG. The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins. Traffic (Copenhagen, Denmark). 14: 458-69. PMID 23350547 DOI: 10.1111/Tra.12046  0.588
2013 Fantus D, Awan Z, Seidah NG, Genest J. Aortic calcification: Novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor. Atherosclerosis. 226: 9-15. PMID 23040868 DOI: 10.1016/J.Atherosclerosis.2012.08.026  0.564
2013 Harihar S, Pounds KM, Iwakuma T, Seidah NG, Welch DR. Abstract 3860: Furin is required for processing KISS1 to kisspeptins. Cancer Research. 73: 3860-3860. DOI: 10.1158/1538-7445.Am2013-3860  0.336
2012 Sun X, Essalmani R, Day R, Khatib AM, Seidah NG, Prat A. Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver. Neoplasia (New York, N.Y.). 14: 1122-31. PMID 23308045 DOI: 10.1593/Neo.121252  0.332
2012 Saavedra YG, Day R, Seidah NG. The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway. The Journal of Biological Chemistry. 287: 43492-501. PMID 23105118 DOI: 10.1074/Jbc.M112.394023  0.349
2012 Maret D, Sadr MS, Sadr ES, Colman DR, Del Maestro RF, Seidah NG. Opposite roles of furin and PC5A in N-cadherin processing. Neoplasia (New York, N.Y.). 14: 880-92. PMID 23097623 DOI: 10.1593/Neo.121250  0.331
2012 Benjannet S, Hamelin J, Chrétien M, Seidah NG. Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation. The Journal of Biological Chemistry. 287: 33745-55. PMID 22875854 DOI: 10.1074/Jbc.M112.399725  0.363
2012 Seidah NG, Poirier S, Denis M, Parker R, Miao B, Mapelli C, Prat A, Wassef H, Davignon J, Hajjar KA, Mayer G. Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. Plos One. 7: e41865. PMID 22848640 DOI: 10.1371/Journal.Pone.0041865  0.624
2012 Abifadel M, Guerin M, Benjannet S, Rabès JP, Le Goff W, Julia Z, Hamelin J, Carreau V, Varret M, Bruckert E, Tosolini L, Meilhac O, Couvert P, Bonnefont-Rousselot D, Chapman J, ... ... Seidah NG, et al. Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia. Atherosclerosis. 223: 394-400. PMID 22683120 DOI: 10.1016/J.Atherosclerosis.2012.04.006  0.303
2012 Seidah NG, Prat A. The biology and therapeutic targeting of the proprotein convertases. Nature Reviews. Drug Discovery. 11: 367-83. PMID 22679642 DOI: 10.1038/Nrd3699  0.365
2012 Refaie S, Gagnon S, Gagnon H, Desjardins R, D'Anjou F, D'Orléans-Juste P, Zhu X, Steiner DF, Seidah NG, Lazure C, Salzet M, Day R. Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. The Journal of Biological Chemistry. 287: 14703-17. PMID 22396549 DOI: 10.1074/Jbc.M111.323220  0.311
2012 Zandberg WF, Gao N, Kumarasamy J, Lehrman MA, Seidah NG, Pinto BM. 5-thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation. Chembiochem : a European Journal of Chemical Biology. 13: 392-401. PMID 22262650 DOI: 10.1002/Cbic.201100647  0.338
2012 Denis M, Marcinkiewicz J, Zaid A, Gauthier D, Poirier S, Lazure C, Seidah NG, Prat A. Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. Circulation. 125: 894-901. PMID 22261195 DOI: 10.1161/Circulationaha.111.057406  0.606
2012 Awan Z, Seidah NG, MacFadyen JG, Benjannet S, Chasman DI, Ridker PM, Genest J. Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial. Clinical Chemistry. 58: 183-9. PMID 22065156 DOI: 10.1373/Clinchem.2011.172932  0.556
2012 Seidah NG, Chrétien M. Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives. Trends in Endocrinology and Metabolism: Tem. 3: 133-40. PMID 18407092 DOI: 10.1016/1043-2760(92)90102-7  0.362
2012 Seidah NG, Poirier S, Denis M, Parker R, Miao B, Mapelli C, Prat A, Wassef H, Davignon J, Hajjar KA, Mayer G. Adenoviral overexpression of AnxA2 in mouse liver significantly increases LDLR levels. Plos One. DOI: 10.1371/Journal.Pone.0041865.G005  0.536
2011 Awan Z, Denis M, Bailey D, Giaid A, Prat A, Goltzman D, Seidah NG, Genest J. The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography. Atherosclerosis. 219: 455-62. PMID 22051553 DOI: 10.1016/J.Atherosclerosis.2011.08.035  0.553
2011 Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC, Davignon J, Seidah NG, Mbikay M, Chrétien M. Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture. Clinical Chemistry. 57: 1415-23. PMID 21813713 DOI: 10.1373/Clinchem.2011.165191  0.352
2011 Sun X, Essalmani R, Susan-Resiga D, Prat A, Seidah NG. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. The Journal of Biological Chemistry. 286: 29063-73. PMID 21700711 DOI: 10.1074/Jbc.M111.242479  0.325
2011 Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Benjannet S, Chamberland A, Day R, Szumska D, Constam D, Bhattacharya S, Prat A, Seidah NG. Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. The Journal of Biological Chemistry. 286: 22785-94. PMID 21550985 DOI: 10.1074/Jbc.M111.233577  0.365
2011 Zandberg WF, Benjannet S, Hamelin J, Pinto BM, Seidah NG. N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1. Glycobiology. 21: 1290-300. PMID 21527438 DOI: 10.1093/Glycob/Cwr060  0.377
2011 Seidah NG. What lies ahead for the proprotein convertases? Annals of the New York Academy of Sciences. 1220: 149-61. PMID 21388412 DOI: 10.1111/J.1749-6632.2010.05883.X  0.369
2011 Denis N, Palmer-Smith H, Elisma F, Busuttil A, Wright TG, Bou Khalil M, Prat A, Seidah NG, Chrétien M, Mayne J, Figeys D. Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells. Journal of Proteome Research. 10: 2011-26. PMID 21332221 DOI: 10.1021/Pr2000072  0.379
2011 Roubtsova A, Munkonda MN, Awan Z, Marcinkiewicz J, Chamberland A, Lazure C, Cianflone K, Seidah NG, Prat A. Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 785-91. PMID 21273557 DOI: 10.1161/Atvbaha.110.220988  0.571
2011 Rousselet E, Benjannet S, Marcinkiewicz E, Asselin MC, Lazure C, Seidah NG. Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. The Journal of Biological Chemistry. 286: 9185-95. PMID 21209099 DOI: 10.1074/Jbc.M110.189936  0.343
2011 Essalmani R, Susan-Resiga D, Chamberland A, Abifadel M, Creemers JW, Boileau C, Seidah NG, Prat A. In vivo evidence that furin from hepatocytes inactivates PCSK9. The Journal of Biological Chemistry. 286: 4257-63. PMID 21147780 DOI: 10.1074/Jbc.M110.192104  0.396
2011 Tremblay AJ, Lamarche B, Lemelin V, Hoos L, Benjannet S, Seidah NG, Davis HR, Couture P. Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men. Journal of Lipid Research. 52: 558-65. PMID 21123766 DOI: 10.1194/Jlr.M011080  0.313
2011 Rousselet E, Benjannet S, Hamelin J, Canuel M, Seidah NG. The proprotein convertase PC7: unique zymogen activation and trafficking pathways. The Journal of Biological Chemistry. 286: 2728-38. PMID 21075846 DOI: 10.1074/Jbc.M110.192344  0.343
2011 Gorski JP, Huffman NT, Chittur S, Midura RJ, Black C, Oxford J, Seidah NG. Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization. The Journal of Biological Chemistry. 286: 1836-49. PMID 21075843 DOI: 10.1074/Jbc.M110.151647  0.31
2010 Benjannet S, Saavedra YG, Hamelin J, Asselin MC, Essalmani R, Pasquato A, Lemaire P, Duke G, Miao B, Duclos F, Parker R, Mayer G, Seidah NG. Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events. The Journal of Biological Chemistry. 285: 40965-78. PMID 20937814 DOI: 10.1074/Jbc.M110.154815  0.349
2010 Chitramuthu BP, Baranowski DC, Cadieux B, Rousselet E, Seidah NG, Bennett HP. Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 2933-46. PMID 20882679 DOI: 10.1002/Dvdy.22426  0.331
2010 Davignon J, Dubuc G, Seidah NG. The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis. Current Atherosclerosis Reports. 12: 308-15. PMID 20623344 DOI: 10.1007/S11883-010-0123-6  0.349
2010 Gupta N, Fisker N, Asselin MC, Lindholm M, Rosenbohm C, Ørum H, Elmén J, Seidah NG, Straarup EM. A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo. Plos One. 5: e10682. PMID 20498851 DOI: 10.1371/Journal.Pone.0010682  0.349
2010 Levy E, Lalonde G, Delvin E, Elchebly M, Précourt LP, Seidah NG, Spahis S, Rabasa-Lhoret R, Ziv E. Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus. Endocrinology. 151: 958-70. PMID 20130116 DOI: 10.1210/En.2009-0866  0.344
2010 Dong B, Wu M, Li H, Kraemer FB, Adeli K, Seidah NG, Park SW, Liu J. Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. Journal of Lipid Research. 51: 1486-95. PMID 20048381 DOI: 10.1194/Jlr.M003566  0.34
2010 Mbikay M, Sirois F, Mayne J, Wang GS, Chen A, Dewpura T, Prat A, Seidah NG, Chretien M, Scott FW. PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. Febs Letters. 584: 701-6. PMID 20026049 DOI: 10.1016/J.Febslet.2009.12.018  0.312
2010 Dubuc G, Tremblay M, Paré G, Jacques H, Hamelin J, Benjannet S, Boulet L, Genest J, Bernier L, Seidah NG, Davignon J. A new method for measurement of total plasma PCSK9: clinical applications. Journal of Lipid Research. 51: 140-9. PMID 19571328 DOI: 10.1194/Jlr.M900273-Jlr200  0.319
2009 Iatan I, Dastani Z, Do R, Weissglas-Volkov D, Ruel I, Lee JC, Huertas-Vazquez A, Taskinen MR, Prat A, Seidah NG, Pajukanta P, Engert JC, Genest J. Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. Circulation. Cardiovascular Genetics. 2: 467-75. PMID 20031622 DOI: 10.1161/Circgenetics.109.877811  0.334
2009 Poirier S, Mayer G, Poupon V, McPherson PS, Desjardins R, Ly K, Asselin MC, Day R, Duclos FJ, Witmer M, Parker R, Prat A, Seidah NG. Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. The Journal of Biological Chemistry. 284: 28856-64. PMID 19635789 DOI: 10.1074/Jbc.M109.037085  0.626
2009 Leblond F, Seidah NG, Précourt LP, Delvin E, Dominguez M, Levy E. Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G805-15. PMID 19179626 DOI: 10.1152/Ajpgi.90424.2008  0.343
2009 Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. The Journal of Biological Chemistry. 284: 3793-803. PMID 19074428 DOI: 10.1074/Jbc.M808920200  0.337
2009 Seidah NG. PCSK9 as a therapeutic target of dyslipidemia. Expert Opinion On Therapeutic Targets. 13: 19-28. PMID 19063703 DOI: 10.1517/14728220802600715  0.369
2008 Mayer G, Poirier S, Seidah NG. Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. The Journal of Biological Chemistry. 283: 31791-801. PMID 18799458 DOI: 10.1074/Jbc.M805971200  0.622
2008 Chrétien M, Seidah NG, Basak A, Mbikay M. Proprotein convertases as therapeutic targets. Expert Opinion On Therapeutic Targets. 12: 1289-300. PMID 18781827 DOI: 10.1517/14728222.12.10.1289  0.335
2008 Zaid A, Roubtsova A, Essalmani R, Marcinkiewicz J, Chamberland A, Hamelin J, Tremblay M, Jacques H, Jin W, Davignon J, Seidah NG, Prat A. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology (Baltimore, Md.). 48: 646-54. PMID 18666258 DOI: 10.1002/Hep.22354  0.336
2008 Ozden S, Lucas-Hourani M, Ceccaldi PE, Basak A, Valentine M, Benjannet S, Hamelin J, Jacob Y, Mamchaoui K, Mouly V, Desprès P, Gessain A, Butler-Browne G, Chrétien M, Tangy F, ... ... Seidah NG, et al. Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein. The Journal of Biological Chemistry. 283: 21899-908. PMID 18559340 DOI: 10.1074/Jbc.M802444200  0.301
2008 Dewpura T, Raymond A, Hamelin J, Seidah NG, Mbikay M, Chrétien M, Mayne J. PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans. The Febs Journal. 275: 3480-93. PMID 18498363 DOI: 10.1111/J.1742-4658.2008.06495.X  0.301
2008 Essalmani R, Zaid A, Marcinkiewicz J, Chamberland A, Pasquato A, Seidah NG, Prat A. In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proceedings of the National Academy of Sciences of the United States of America. 105: 5750-5. PMID 18378898 DOI: 10.1073/Pnas.0709428105  0.334
2008 Seidah NG, Mayer G, Zaid A, Rousselet E, Nassoury N, Poirier S, Essalmani R, Prat A. The activation and physiological functions of the proprotein convertases. The International Journal of Biochemistry & Cell Biology. 40: 1111-25. PMID 18343183 DOI: 10.1016/J.Biocel.2008.01.030  0.634
2008 Scamuffa N, Siegfried G, Bontemps Y, Ma L, Basak A, Cherel G, Calvo F, Seidah NG, Khatib AM. Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells. The Journal of Clinical Investigation. 118: 352-63. PMID 18064302 DOI: 10.1172/Jci32040  0.304
2008 Xiao Y, Chen G, Richard J, Rougeau N, Li H, Seidah NG, Cohen EA. Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases. Virology. 372: 384-97. PMID 18061232 DOI: 10.1016/J.Virol.2007.10.036  0.319
2008 Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. The Journal of Biological Chemistry. 283: 2363-72. PMID 18039658 DOI: 10.1074/Jbc.M708098200  0.622
2008 Mayer G, Hamelin J, Asselin MC, Pasquato A, Marcinkiewicz E, Tang M, Tabibzadeh S, Seidah NG. The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates. The Journal of Biological Chemistry. 283: 2373-84. PMID 18039650 DOI: 10.1074/Jbc.M708763200  0.33
2007 De Windt A, Rai M, Bernier L, Thelen K, Soini J, Lefebvre C, Chintawar S, Lavigne J, Saarinen L, Kytömäki L, Munzer JS, Lütjohann D, Pandolfo M, Davignon J, Seidah NG, et al. Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells. Dna and Cell Biology. 26: 765-72. PMID 17867930 DOI: 10.1089/Dna.2007.0624  0.341
2007 Dikeakos JD, Mercure C, Lacombe MJ, Seidah NG, Reudelhuber TL. PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism. The Febs Journal. 274: 4094-102. PMID 17645548 DOI: 10.1111/J.1742-4658.2007.05937.X  0.342
2007 Pullikotil P, Benjannet S, Mayne J, Seidah NG. The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization. The Journal of Biological Chemistry. 282: 27402-13. PMID 17623657 DOI: 10.1074/Jbc.M703200200  0.334
2007 Billova S, Galanopoulou AS, Seidah NG, Qiu X, Kumar U. Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain Neuroscience. 147: 403-418. PMID 17543468 DOI: 10.1016/J.Neuroscience.2007.04.039  0.312
2007 Mbikay M, Mayne J, Seidah NG, Chrétien M. Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms. Medical Hypotheses. 69: 1010-7. PMID 17502126 DOI: 10.1016/J.Mehy.2007.03.018  0.31
2007 Mbikay M, Croissandeau G, Sirois F, Anini Y, Mayne J, Seidah NG, Chrétien M. A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat. Developmental Biology. 306: 584-98. PMID 17490633 DOI: 10.1016/J.Ydbio.2007.03.523  0.319
2007 Nassoury N, Blasiole DA, Tebon Oler A, Benjannet S, Hamelin J, Poupon V, McPherson PS, Attie AD, Prat A, Seidah NG. The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR. Traffic (Copenhagen, Denmark). 8: 718-32. PMID 17461796 DOI: 10.1111/J.1600-0854.2007.00562.X  0.367
2007 Seidah NG, Prat A. The proprotein convertases are potential targets in the treatment of dyslipidemia Journal of Molecular Medicine. 85: 685-696. PMID 17351764 DOI: 10.1007/S00109-007-0172-7  0.397
2006 Guillemot J, Barbier L, Thouennon E, Vallet-Erdtmann V, Montero-Hadjadje M, Lefebvre H, Klein M, Muresan M, Plouin PF, Seidah N, Vaudry H, Anouar Y, Yon L. Expression and processing of the neuroendocrine protein secretogranin II in benign and malignant pheochromocytomas. Annals of the New York Academy of Sciences. 1073: 527-32. PMID 17102121 DOI: 10.1196/Annals.1353.056  0.302
2006 Scamuffa N, Calvo F, Chrétien M, Seidah NG, Khatib AM. Proprotein convertases: Lessons from knockouts Faseb Journal. 20: 1954-1963. PMID 17012247 DOI: 10.1096/Fj.05-5491Rev  0.369
2006 Seidah NG, Khatib AM, Prat A. The proprotein convertases and their implication in sterol and/or lipid metabolism Biological Chemistry. 387: 871-877. PMID 16913836 DOI: 10.1515/Bc.2006.110  0.381
2006 Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: Functional consequences of natural mutations and post-translational modifications Journal of Biological Chemistry. 281: 30561-30572. PMID 16912035 DOI: 10.1074/Jbc.M606495200  0.372
2006 Poirier S, Prat A, Marcinkiewicz E, Paquin J, Chitramuthu BP, Baranowski D, Cadieux B, Bennett HPJ, Seidah NG. Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system Journal of Neurochemistry. 98: 838-850. PMID 16893422 DOI: 10.1111/J.1471-4159.2006.03928.X  0.597
2006 Pasquato A, Pullikotil P, Asselin MC, Vacatello M, Paolillo L, Ghezzo F, Basso F, Di Bello C, Dettin M, Seidah NG. The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors. The Journal of Biological Chemistry. 281: 23471-81. PMID 16790437 DOI: 10.1074/Jbc.M513675200  0.331
2006 Essalmani R, Hamelin J, Marcinkiewicz J, Chamberland A, Mbikay M, Chrétien M, Seidah NG, Prat A. Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse Molecular and Cellular Biology. 26: 354-361. PMID 16354705 DOI: 10.1128/Mcb.26.1.354-361.2006  0.332
2006 Siegfried G, Basak A, Prichett-Pejic W, Scamuffa N, Ma L, Benjannet S, Veinot JP, Calvo F, Seidah N, Khatib AM. Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases. Oncogene. 24: 6925-35. PMID 16007151 DOI: 10.1038/Sj.Onc.1208838  0.307
2005 Salvas A, Benjannet S, Reudelhuber TL, Chrétien M, Seidah NG. Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi. Febs Letters. 579: 5621-5. PMID 16213495 DOI: 10.1016/J.Febslet.2005.09.029  0.317
2005 Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ. Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. The Journal of Biological Chemistry. 280: 36551-9. PMID 16109723 DOI: 10.1074/Jbc.M502264200  0.389
2005 Attie AD, Seidah NG. Dual regulation of the LDL receptor--some clarity and new questions. Cell Metabolism. 1: 290-2. PMID 16054075 DOI: 10.1016/J.Cmet.2005.04.006  0.326
2005 De Cicco RL, Bassi DE, Zucker S, Seidah NG, Klein-Szanto AJP. Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin Cancer Research. 65: 4162-4171. PMID 15899807 DOI: 10.1158/0008-5472.Can-04-2820  0.313
2005 Stawowy P, Kallisch H, Borges Pereira Stawowy N, Stibenz D, Veinot JP, Gräfe M, Seidah NG, Chrétien M, Fleck E, Graf K. Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis. Virchows Archiv : An International Journal of Pathology. 446: 351-9. PMID 15756593 DOI: 10.1007/S00428-004-1198-7  0.303
2005 Lalanne F, Lambert G, Amar MJA, Chétiveaux M, Zaïr Y, Jarnoux AL, Ouguerram K, Friburg J, Seidah NG, Brewer HB, Krempf M, Costet P. Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells Journal of Lipid Research. 46: 1312-1319. PMID 15741654 DOI: 10.1194/Jlr.M400396-Jlr200  0.365
2005 Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG. β-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: Binding partners processed by furin Journal of Neurochemistry. 92: 93-102. PMID 15606899 DOI: 10.1111/J.1471-4159.2004.02840.X  0.301
2005 Bergeron E, Vincent MJ, Wickham L, Hamelin J, Basak A, Nichol ST, Chrétien M, Seidah NG. Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus. Biochemical and Biophysical Research Communications. 326: 554-63. PMID 15596135 DOI: 10.1016/J.Bbrc.2004.11.063  0.328
2004 Benjannet S, Cromlish JA, Diallo K, Chrétien M, Seidah NG. The metabolism of β-amyloid converting enzyme and β-amyloid precursor protein processing Biochemical and Biophysical Research Communications. 325: 235-242. PMID 15522224 DOI: 10.1016/J.Bbrc.2004.10.019  0.305
2004 Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, ... ... Seidah NG, et al. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. The Journal of Biological Chemistry. 279: 48865-75. PMID 15358785 DOI: 10.1074/Jbc.M409699200  0.37
2004 Dubuc G, Chamberland A, Wassef H, Davignon J, Seidah NG, Bernier L, Prat A. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1454-9. PMID 15178557 DOI: 10.1161/01.Atv.0000134621.14315.43  0.309
2004 Stawowy P, Kallisch H, Veinot JP, Kilimnik A, Prichett W, Goetze S, Seidah NG, Chrétien M, Fleck E, Graf K. Endoproteolytic Activation of αv Integrin by Proprotein Convertase PC5 Is Required for Vascular Smooth Muscle Cell Adhesion to Vitronectin and Integrin-Dependent Signaling Circulation. 109: 770-776. PMID 14970114 DOI: 10.1161/01.Cir.0000112583.50762.De  0.32
2003 Winsky-Sommerer R, Grouselle D, Rougeot C, Laurent V, David JP, Delacourte A, Dournaud P, Seidah NG, Lindberg I, Trottier S, Epelbaum J. The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease. Neuroscience. 122: 437-47. PMID 14614908 DOI: 10.1016/S0306-4522(03)00560-8  0.312
2003 Vincent MJ, Sanchez AJ, Erickson BR, Basak A, Chretien M, Seidah NG, Nichol ST. Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. Journal of Virology. 77: 8640-9. PMID 12885882 DOI: 10.1128/Jvi.77.16.8640-8649.2003  0.322
2003 Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M, Mori K. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. The Journal of Biological Chemistry. 278: 31024-32. PMID 12782636 DOI: 10.1074/Jbc.M300923200  0.301
2003 Abifadel M, Varret M, Rabès JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, Derré A, Villéger L, Farnier M, Beucler I, Bruckert E, ... ... Seidah NG, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia Nature Genetics. 34: 154-156. PMID 12730697 DOI: 10.1038/Ng1161  0.335
2003 Stawowy P, Graf K, Goetze S, Roser M, Chrétien M, Seidah NG, Fleck E, Marcinkiewicz M. Coordinated regulation and colocalization of αv integrin and its activating enzyme proprotein convertase PC5 in vivo Histochemistry and Cell Biology. 119: 239-245. PMID 12649739 DOI: 10.1007/S00418-003-0506-7  0.325
2003 Doblinger A, Becker A, Seidah NG, Laslop A. Proteolytic processing of chromogranin A by the prohormone convertase PC2 Regulatory Peptides. 111: 111-116. PMID 12609757 DOI: 10.1016/S0167-0115(02)00262-8  0.364
2003 Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proceedings of the National Academy of Sciences of the United States of America. 100: 928-33. PMID 12552133 DOI: 10.1073/Pnas.0335507100  0.317
2003 Conesa M, Prat A, Mort JS, Marvaldi J, Lissitzky JC, Seidah NG. Down-regulation of αv/β3 integrin via misrouting to lysosomes by overexpression of a β3Lamp1 fusion protein Biochemical Journal. 370: 703-711. PMID 12444923 DOI: 10.1042/Bj20021301  0.304
2003 Nour N, Basak A, Chrétien M, Seidah NG. Structure-function analysis of the prosegment of the proprotein convertase PC5A. The Journal of Biological Chemistry. 278: 2886-95. PMID 12414802 DOI: 10.1074/Jbc.M208009200  0.323
2002 Seidah NG, Prat A. Precursor convertases in the secretory pathway, cytosol and extracellular milieu Essays in Biochemistry. 38: 79-94. PMID 12463163 DOI: 10.1042/Bse0380079  0.372
2002 Villeneuve P, Feliciangeli S, Croissandeau G, Seidah NG, Mbikay M, Kitabgi P, Beaudet A. Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. Journal of Neurochemistry. 82: 783-93. PMID 12358783 DOI: 10.1046/J.1471-4159.2002.00988.X  0.317
2002 Mbikay M, Raffin-Sanson ML, Sirois F, Kalenga L, Chrétien M, Seidah NG. Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene. Brain Research. Molecular Brain Research. 102: 35-47. PMID 12191492 DOI: 10.1016/S0169-328X(02)00180-8  0.316
2002 Hospital V, Nishi E, Klagsbrun M, Cohen P, Seidah NG, Prat A. The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF). The Biochemical Journal. 367: 229-38. PMID 12095415 DOI: 10.1042/Bj20020822  0.302
2001 Elagoz A, Benjannet S, Mammarbassi A, Wickham L, Seidah NG. Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity. The Journal of Biological Chemistry. 277: 11265-75. PMID 11756446 DOI: 10.1074/Jbc.M109011200  0.346
2001 Lenz O, ter Meulen J, Klenk HD, Seidah NG, Garten W. The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P. Proceedings of the National Academy of Sciences of the United States of America. 98: 12701-5. PMID 11606739 DOI: 10.1073/Pnas.221447598  0.302
2001 Khatib AM, Siegfried G, Prat A, Luis J, Chrétien M, Metrakos P, Seidah NG. Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. The Journal of Biological Chemistry. 276: 30686-93. PMID 11402025 DOI: 10.1074/Jbc.M101725200  0.321
2001 Lopez-Perez E, Zhang Y, Frank SJ, Creemers J, Seidah N, Checler F. Constitutive α-secretase cleavage of the β-amyloid precursor protein in the furin-deficient LoVo cell line: Involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10 Journal of Neurochemistry. 76: 1532-1539. PMID 11238737 DOI: 10.1046/J.1471-4159.2001.00180.X  0.32
2001 Stawowy P, Marcinkiewicz J, Graf K, Seidah NG, Chrétien M, Fleck E, Marcinkiewicz M. Selective expression of the proprotein convertases furin, pc5, and pc7 in proliferating vascular smooth muscle cells of the rat aorta in vitro. Journal of Histochemistry and Cytochemistry. 49: 323-331. PMID 11181735 DOI: 10.1177/002215540104900306  0.318
2001 Nillni EA, Aird F, Seidah NG, Todd RB, Koenig JI. PreproTRH(178-199) and two novel peptides (pFQ7 and pSE14) derived from its processing, which are produced in the paraventricular nucleus of the rat hypothalamus, are regulated during suckling. Endocrinology. 142: 896-906. PMID 11159863 DOI: 10.1210/Endo.142.2.7954  0.349
2001 Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer JS, Basak A, Lazure C, Cromlish JA, Sisodia S, Checler F, Chrétien M, Seidah NG. Post-translational processing of β-secretase (β -amyloid-converting enzyme) and its ectodomain shedding: The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production Journal of Biological Chemistry. 276: 10879-10887. PMID 11152688 DOI: 10.1074/Jbc.M009899200  0.316
2001 MBIKAY M, SEIDAH NG, CHRÉTIEN M. Neuroendocrine secretory protein 7B2: structure, expression and functions Biochemical Journal. 357: 329-342. DOI: 10.1042/Bj3570329  0.389
2001 BASAK A, ZHONG M, MUNZER JS, CHRÉTIEN M, SEIDAH NG. Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides Biochemical Journal. 353: 537-545. DOI: 10.1042/0264-6021:3530537  0.326
2000 Villeneuve P, Seidah NG, Beaudet A. Immunohistochemical evidence for the implication of PC1 in the processing of proneurotensin in rat brain. Neuroreport. 11: 3443-7. PMID 11095496 DOI: 10.1097/00001756-200011090-00009  0.311
2000 Rovère C, Mort JS, Chrétien M, Seidah NG. Cathepsin-B fusion proteins misroute secretory protein partners such as the proprotein convertase PC2-7B2 complex toward the lysosomal degradation pathways. Biochemical and Biophysical Research Communications. 276: 594-9. PMID 11027518 DOI: 10.1006/Bbrc.2000.3478  0.328
2000 Jutras I, Seidah NG, Reudelhuber TL. A predicted alpha -helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway. The Journal of Biological Chemistry. 275: 40337-43. PMID 11006274 DOI: 10.1074/Jbc.M004757200  0.323
2000 Hwang SR, Ng SM, Steineckert B, Seidah NG, Hook VY. Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2. Dna and Cell Biology. 19: 409-19. PMID 10945231 DOI: 10.1089/10445490050085906  0.323
2000 Villeneuve P, Lafortune L, Seidah NG, Kitabgi P, Beaudet A. Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain. The Journal of Comparative Neurology. 424: 461-75. PMID 10906713 DOI: 10.1002/1096-9861(20000828)424:3<461::Aid-Cne5>3.0.Co;2-J  0.335
2000 Winsky-Sommerer R, Benjannet S, Rovère C, Barbero P, Seidah NG, Epelbaum J, Dournaud P. Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system Journal of Comparative Neurology. 424: 439-460. PMID 10906712 DOI: 10.1002/1096-9861(20000828)424:3<439::Aid-Cne4>3.0.Co;2-1  0.337
2000 Lesage G, Prat A, Lacombe J, Thomas DY, Seidah NG, Boileau G. The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function Molecular Biology of the Cell. 11: 1947-1957. PMID 10848621 DOI: 10.1091/Mbc.11.6.1947  0.331
2000 Seidah NG, Benjannet S, Hamelin J, Mamarbachi AM, Basak A, Marcinkiewicz J, Mbikay M, Chrétien M, Marcinkiewicz M. The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1. Annals of the New York Academy of Sciences. 885: 57-74. PMID 10816641 DOI: 10.1111/J.1749-6632.1999.Tb08665.X  0.349
2000 Ghaddar G, Ruchon AF, Carpentier M, Marcinkiewicz M, Seidah NG, Crine P, Desgroseillers L, Boileau G. Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family Biochemical Journal. 347: 419-429. PMID 10749671 DOI: 10.1042/0264-6021:3470419  0.347
2000 Bhattacharjya S, Xu P, Zhong M, Chrétien M, Seidah NG, Ni F. Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7. Biochemistry. 39: 2868-77. PMID 10715106 DOI: 10.1021/Bi9923961  0.319
2000 Seidah NG, Chrétien M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Research. 848: 45-62. PMID 10701998 DOI: 10.1016/S0006-8993(99)01909-5  0.363
2000 Touré BB, Munzer JS, Basak A, Benjannet S, Rochemont J, Lazure C, Chrétien M, Seidah NG. Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment. The Journal of Biological Chemistry. 275: 2349-58. PMID 10644685 DOI: 10.1074/Jbc.275.4.2349  0.35
2000 Muller L, Picart R, Barret A, Seidah NG, Tougard C. Immunocytochemical localization of the prohormone convertases PC1 and PC2 in rat prolactin cells. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 46: 101-8. PMID 9405499 DOI: 10.1177/002215549804600113  0.346
2000 HOSPITAL V, CHESNEAU V, BALOGH A, JOULIE C, SEIDAH NG, COHEN P, PRAT A. N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface Biochemical Journal. 349: 587-597. DOI: 10.1042/Bj3490587  0.348
2000 LISSITZKY J, LUIS J, MUNZER JS, BENJANNET S, PARAT F, CHRÉTIEN M, MARVALDI J, SEIDAH NG. Endoproteolytic processing of integrin pro-α subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7 Biochemical Journal. 346: 133-138. DOI: 10.1042/Bj3460133  0.333
2000 Lopez-Perez E, Seidah N. PC7 contributes to the processing of the Alzheimer's βamyloid precursor protein in human cells Neurobiology of Aging. 21: 96-97. DOI: 10.1016/S0197-4580(00)82657-3  0.301
1999 Jin L, Kulig E, Qian X, Scheithauer BW, Young WF, Davis DH, Seidah NG, Chretien M, Lloyd RV. Distribution and regulation of proconvertases PC1 and PC2 in human pituitary adenomas. Pituitary. 1: 187-95. PMID 11081197 DOI: 10.1023/A:1009909232243  0.348
1999 Zhong M, Munzer JS, Basak A, Benjannet S, Mowla SJ, Decroly E, Chrétien M, Seidah NG. The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity. The Journal of Biological Chemistry. 274: 33913-20. PMID 10567353 DOI: 10.1074/Jbc.274.48.33913  0.349
1999 Canaff L, Bennett HP, Hou Y, Seidah NG, Hendy GN. Proparathyroid hormone processing by the proprotein convertase-7: comparison with furin and assessment of modulation of parathyroid convertase messenger ribonucleic acid levels by calcium and 1,25-dihydroxyvitamin D3. Endocrinology. 140: 3633-42. PMID 10433221 DOI: 10.1210/Endo.140.8.6882  0.324
1999 Villeneuve P, Seidah NG, Beaudet A. Immunohistochemical distribution of the prohormone convertase PC5-A in rat brain. Neuroscience. 92: 641-54. PMID 10408612 DOI: 10.1016/S0306-4522(98)00763-5  0.301
1999 Rovère C, Luis J, Lissitzky JC, Basak A, Marvaldi J, Chrétien M, Seidah NG. The RGD motif and the C-terminal segment of proprotein convertase 1 are critical for its cellular trafficking but not for its intracellular binding to integrin alpha5beta1. The Journal of Biological Chemistry. 274: 12461-7. PMID 10212221 DOI: 10.1074/Jbc.274.18.12461  0.372
1999 Gangnon F, Danger JM, Jegou S, Vieau D, Seidah NG, Vaudry H. Molecular cloning, characterization of cDNA, and distribution of mRNA encoding the frog prohormone convertase PC1. The Journal of Comparative Neurology. 405: 160-72. PMID 10023807 DOI: 10.1002/(Sici)1096-9861(19990308)405:2<160::Aid-Cne2>3.0.Co;2-Y  0.356
1999 Seidah NG, Mowla SJ, Hamelin J, Mamarbachi AM, Benjannet S, Touré BB, Basak A, Munzer JS, Marcinkiewicz J, Zhong M, Barale JC, Lazure C, Murphy RA, Chrétien M, Marcinkiewicz M. Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. Proceedings of the National Academy of Sciences of the United States of America. 96: 1321-6. PMID 9990022 DOI: 10.1073/Pnas.96.4.1321  0.345
1999 Boudreault A, Gauthier D, Rondeau N, Savaria D, Seidah NG, Chrétien M, Lazure C. Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells. Protein Expression and Purification. 14: 353-66. PMID 9882569 DOI: 10.1006/Prep.1998.0964  0.312
1999 BASAK A, TOURÉ BB, LAZURE C, MBIKAY M, CHRÉTIEN M, SEIDAH NG. Enzymic characterization in vitro of recombinant proprotein convertase PC4 Biochemical Journal. 343: 29-37. DOI: 10.1042/Bj3430029  0.349
1999 BASAK A, COOPER S, ROBERGE AG, BANIK UK, CHRÉTIEN M, SEIDAH NG. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters Biochemical Journal. 338: 107-113. DOI: 10.1042/Bj3380107  0.306
1998 Jarriault S, Le Bail O, Hirsinger E, Pourquie O, Logeat F, Strong CF, Brou C, Seidah NG, Israel A. Delta-1 activation of Notch-1 signaling results in HES-1 transactivation Molecular and Cellular Biology. 18: 7423-7431. PMID 9819428 DOI: 10.1128/Mcb.18.12.7423  0.32
1998 Girardin SE, Benjannet S, Barale JC, Chrétien M, Seidah NG. The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit-1/GHF-1-independent pathway in corticotroph AtT20 cells Febs Letters. 431: 333-338. PMID 9714537 DOI: 10.1016/S0014-5793(98)00787-X  0.333
1998 Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah NG, Israël A. The Notch1 receptor is cleaved constitutively by a furin-like convertase Proceedings of the National Academy of Sciences of the United States of America. 95: 8108-8112. PMID 9653148 DOI: 10.1073/Pnas.95.14.8108  0.333
1998 Benjannet S, Mamarbachi AM, Hamelin J, Savaria D, Munzer JS, Chrétien M, Seidah NG. Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity. Febs Letters. 428: 37-42. PMID 9645470 DOI: 10.1016/S0014-5793(98)00480-3  0.376
1998 Lazure C, Gauthier D, Jean F, Boudreault A, Seidah NG, Bennett HP, Hendy GN. In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor. The Journal of Biological Chemistry. 273: 8572-80. PMID 9535830 DOI: 10.1074/Jbc.273.15.8572  0.318
1998 Laslop A, Weiss C, Savaria D, Eiter C, Tooze SA, Seidah NG, Winkler H. Proteolytic processing of chromogranin B and secretogranin II by prohormone convertases. Journal of Neurochemistry. 70: 374-83. PMID 9422384 DOI: 10.1046/J.1471-4159.1998.70010374.X  0.325
1997 Seidah NG, Chrétien M. Eukaryotic protein processing: endoproteolysis of precursor proteins. Current Opinion in Biotechnology. 8: 602-7. PMID 9353231 DOI: 10.1016/S0958-1669(97)80036-5  0.362
1997 Lusson J, Benjannet S, Hamelin J, Savaria D, Chrétien M, Seidah NG. The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking. The Biochemical Journal. 737-44. PMID 9307023 DOI: 10.1042/Bj3260737  0.371
1997 Basak A, Ernst B, Brewer D, Seidah NG, Munzer JS, Lazure C, Lajoie GA. Histidine-rich human salivary peptides are inhibitors of proprotein convertases furin and PC7 but act as substrates for PC1 Journal of Peptide Research. 49: 596-603. PMID 9266488 DOI: 10.1111/J.1399-3011.1997.Tb01168.X  0.3
1997 Sánchez E, Charli JL, Morales C, Corkidi G, Seidah NG, Joseph-Bravo P, Uribe RM. Expression of the proprotein convertases PC1 and PC2 mRNAs in thyrotropin releasing hormone neurons of the rat paraventricular nucleus of hypothalamus. Brain Research. 761: 77-86. PMID 9247068 DOI: 10.1016/S0006-8993(97)00280-1  0.311
1997 Munzer JS, Basak A, Zhong M, Mamarbachi A, Hamelin J, Savaria D, Lazure C, Hendy GN, Benjannet S, Chrétien M, Seidah NG. In vitro characterization of the novel proprotein convertase PC7. The Journal of Biological Chemistry. 272: 19672-81. PMID 9242622 DOI: 10.1074/Jbc.272.32.19672  0.371
1997 Basak A, Boudreault A, Chen A, Chrétien M, Seidah NG, Lazure C. Application of the multiple antigenic peptides (MAP) strategy to the production of prohormone convertases antibodies: synthesis, characterization and use of 8-branched immunogenic peptides. Journal of Peptide Science : An Official Publication of the European Peptide Society. 1: 385-95. PMID 9223018 DOI: 10.1002/Psc.310010606  0.31
1997 Hörsch D, Day R, Seidah NG, Weihe E, Schäfer MK. Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal. Peptides. 18: 755-60. PMID 9213372 DOI: 10.1016/S0196-9781(96)00029-0  0.333
1997 Mbikay M, Tadros H, Ishida N, Lerner CP, De Lamirande E, Chen A, El-Alfy M, Clermont Y, Seidah NG, Chrétien M, Gagnon C, Simpson EM. Impaired fertility in mice deficient for the testicular germ-cell protease PC4. Proceedings of the National Academy of Sciences of the United States of America. 94: 6842-6. PMID 9192653 DOI: 10.1073/Pnas.94.13.6842  0.307
1997 Jutras I, Seidah NG, Reudelhuber TL, Brechler V. Two activation states of the prohormone convertase PC1 in the secretory pathway. The Journal of Biological Chemistry. 272: 15184-8. PMID 9182540 DOI: 10.1074/Jbc.272.24.15184  0.365
1997 Zheng M, Seidah NG, Pintar JE. The developmental expression in the rat CNS and peripheral tissues of proteases PC5 and PACE4 mRNAs: comparison with other proprotein processing enzymes. Developmental Biology. 181: 268-83. PMID 9013936 DOI: 10.1006/Dbio.1996.8402  0.321
1997 De Bie I, Marcinkiewicz M, Malide D, Lazure C, Nakayama K, Bendayan M, Seidah NG. The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments. The Journal of Cell Biology. 135: 1261-75. PMID 8947550 DOI: 10.1083/Jcb.135.5.1261  0.375
1997 Zhong M, Benjannet S, Lazure C, Munzer S, Seidah NG. Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform. Febs Letters. 396: 31-6. PMID 8906861 DOI: 10.1016/0014-5793(96)01059-9  0.331
1997 Seidah N. Mammalian pro-hormone convertase Biofutur. 1997: 48. DOI: 10.1016/S0294-3506(99)80359-7  0.319
1996 Mercure C, Jutras I, Day R, Seidah NG, Reudelhuber TL. Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex. Hypertension. 28: 840-6. PMID 8901832 DOI: 10.1161/01.Hyp.28.5.840  0.348
1996 Voigt P, Ma YJ, Gonzalez D, Fahrenbach WH, Wetsel WC, Berg-von der Emde K, Hill DF, Taylor KG, Costa ME, Seidah NG, Ojeda SR. Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons. Endocrinology. 137: 2593-605. PMID 8641214 DOI: 10.1210/Endo.137.6.8641214  0.317
1996 Seidah NG, Hamelin J, Mamarbachi M, Dong W, Tardos H, Mbikay M, Chretien M, Day R. cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Proceedings of the National Academy of Sciences of the United States of America. 93: 3388-93. PMID 8622945 DOI: 10.1073/Pnas.93.8.3388  0.343
1996 Campan M, Yoshizumi M, Seidah NG, Lee ME, Bianchi C, Haber E. Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family. Biochemistry. 35: 3797-802. PMID 8620001 DOI: 10.1021/Bi952552D  0.376
1996 Seidah NG, Benjannet S, Pareek S, Savaria D, Hamelin J, Goulet B, Laliberte J, Lazure C, Chrétien M, Murphy RA. Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases. The Biochemical Journal. 314: 951-60. PMID 8615794 DOI: 10.1042/Bj3140951  0.361
1996 Seidah NG, Benjannet S, Pareek S, Chrétien M, Murphy RA. Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases. Febs Letters. 379: 247-50. PMID 8603699 DOI: 10.1016/0014-5793(95)01520-5  0.339
1995 Hoflehner J, Eder U, Laslop A, Seidah NG, Fischer-Colbrie R, Winkler H. Processing of secretogranin II by prohormone convertases: importance of PC1 in generation of secretoneurin. Febs Letters. 360: 294-8. PMID 7883050 DOI: 10.1016/0014-5793(95)00127-U  0.307
1995 Day R, Benjannet S, Matsuuchi L, Kelly RB, Marcinkiewicz M, Chrétien M, Seidah NG. Maintained PC1 and PC2 expression in the AtT-20 variant cell line 6T3 lacking regulated secretion and POMC: restored POMC expression and regulated secretion after cAMP treatment. Dna and Cell Biology. 14: 175-88. PMID 7865135 DOI: 10.1089/Dna.1995.14.175  0.308
1995 Seidah NG, Chrétien M. Pro-protein convertases of subtilisin/kexin family. Methods in Enzymology. 244: 175-88. PMID 7845206 DOI: 10.1016/0076-6879(94)44015-8  0.351
1995 De Bie I, Savaria D, Roebroek AJ, Day R, Lazure C, Van de Ven WJ, Seidah NG. Processing specificity and biosynthesis of the Drosophila melanogaster convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2. The Journal of Biological Chemistry. 270: 1020-8. PMID 7836354 DOI: 10.1074/Jbc.270.3.1020  0.382
1995 Malide D, Seidah NG, Chrétien M, Bendayan M. Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 43: 11-9. PMID 7822759 DOI: 10.1177/43.1.7822759  0.351
1995 Seidah NG, Chrétien M, Day R. The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. Biochimie. 76: 197-209. PMID 7819324 DOI: 10.1016/0300-9084(94)90147-3  0.354
1995 Seidah NG, Barale JC, Marcinkiewicz M, Mattei MG, Day R, Chrétien M. The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary. Dna and Cell Biology. 13: 1163-80. PMID 7811383 DOI: 10.1089/Dna.1994.13.1163  0.322
1995 Beaubien G, Schäfer MKH, Weihe E, Dong W, Chrétien M, Seidah NG, Day R. The distinct gene expression of the pro-hormone convertases in the rat heart suggests potential substrates Cell and Tissue Research. 279: 539-549. PMID 7736551 DOI: 10.1007/Bf00318166  0.303
1995 Benjannet S, Savaria D, Chrétien M, Seidah NG. 7B2 is a specific intracellular binding protein of the prohormone convertase PC2. Journal of Neurochemistry. 64: 2303-11. PMID 7722516 DOI: 10.1046/J.1471-4159.1995.64052303.X  0.319
1995 Hendy GN, Bennett HP, Gibbs BF, Lazure C, Day R, Seidah NG. Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study. The Journal of Biological Chemistry. 270: 9517-25. PMID 7721880 DOI: 10.1074/Jbc.270.16.9517  0.373
1995 Brakch N, Galanopoulou AS, Patel YC, Boileau G, Seidah NG. Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways Febs Letters. 362: 143-146. PMID 7720860 DOI: 10.1016/0014-5793(95)00229-3  0.312
1995 Jean F, Boudreault A, Basak A, Seidah NG, Lazure C. Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor. The Journal of Biological Chemistry. 270: 19225-31. PMID 7642593 DOI: 10.1074/Jbc.270.33.19225  0.31
1995 Brakch N, Dettin M, Scarinci C, Seidah NG, Di Bello C. Structural investigation and kinetic characterization of potential cleavage sites of HIV GP160 by human furin and PC1. Biochemical and Biophysical Research Communications. 213: 356-61. PMID 7639757 DOI: 10.1006/Bbrc.1995.2137  0.316
1995 Bendayan M, Malide D, Ziv E, Levy E, Ben-Sasson R, Kalman R, Bar-On H, Chrétien M, Seidah N. Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus. Journal of Histochemistry and Cytochemistry. 43: 771-784. PMID 7622840 DOI: 10.1177/43.8.7622840  0.305
1995 Galanopoulou AS, Seidah NG, Patel YC. Heterologous processing of rat prosomatostatin to somatostatin-14 by PC2: requirement for secretory cell but not the secretion granule. The Biochemical Journal. 111-8. PMID 7575441 DOI: 10.1042/Bj3110111  0.344
1994 Dupuy A, Lindberg I, Zhou Y, Akil H, Lazure C, Chrétien M, Seidah NG, Day R. Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue. Febs Letters. 337: 60-5. PMID 8276115 DOI: 10.1016/0014-5793(94)80630-6  0.329
1994 Mbikay M, Raffin-Sanson ML, Tadros H, Sirois F, Seidah NG, Chretien M. Structure of the gene for the testis-specific proprotein convertase 4 and of its alternate messenger RNA isoforms Genomics. 20: 231-237. PMID 8020970 DOI: 10.1006/Geno.1994.1158  0.302
1994 Reudelhuber TL, Ramla D, Chiu L, Mercure C, Seidah NG. Proteolytic processing of human prorenin in renal and non-renal tissues Kidney International. 46: 1522-1524. PMID 7699995 DOI: 10.1038/Ki.1994.435  0.314
1993 Schäfer MK, Day R, Cullinan WE, Chrétien M, Seidah NG, Watson SJ. Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 1258-79. PMID 8441010 DOI: 10.1523/Jneurosci.13-03-01258.1993  0.335
1993 Benjannet S, Rondeau N, Paquet L, Boudreault A, Lazure C, Chrétien M, Seidah NG. Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2. The Biochemical Journal. 735-43. PMID 8397508 DOI: 10.1042/Bj2940735  0.338
1993 Marcinkiewicz M, Day R, Seidah NG, Chrétien M. Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin. Proceedings of the National Academy of Sciences of the United States of America. 90: 4922-6. PMID 8389457 DOI: 10.1073/Pnas.90.11.4922  0.311
1993 Ouimet T, Mammarbachi A, Cloutier T, Seidah NG, Castellucci VF. cDNA structure and in situ localization of the Aplysia californica pro-hormone convertase PC2 Febs Letters. 330: 343-346. PMID 8375506 DOI: 10.1016/0014-5793(93)80901-6  0.341
1993 Lusson J, Vieau D, Hamelin J, Day R, Chrétien M, Seidah NG. cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 6691-5. PMID 8341687 DOI: 10.1073/Pnas.90.14.6691  0.342
1993 Basak A, Yuan XW, Harris R, Seidah NG, Chrétien M. Synthesis of the segment (11-23) located in the first tandem repeat of plasma kallikrein: comparative binding studies of this and another segment (328-343) to high-molecular-mass kininogen. Journal of Chromatography. 615: 251-64. PMID 8335703 DOI: 10.1016/0378-4347(93)80339-6  0.311
1993 Jean F, Basak A, Rondeau N, Benjannet S, Hendy GN, Seidah NG, Chrétien M, Lazure C. Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells. The Biochemical Journal. 891-900. PMID 8318017 DOI: 10.1042/Bj2920891  0.352
1993 Lin HL, Day NC, Ueda Y, Martin DK, Dixon JE, Seidah NG, Akil H. Tissue-specific and substrate-specific endoproteolytic cleavage of monkey pro-opiomelanocortin in heterologous endocrine cells: processing at Lys-Lys dibasic pairs. Neuroendocrinology. 58: 94-105. PMID 7903430 DOI: 10.1159/000126518  0.304
1993 Clark DA, Day R, Seidah N, Moody TW, Cuttitta F, Davis TP. Protease inhibitors suppress in vitro growth of human small cell lung cancer. Peptides. 14: 1021-8. PMID 7506831 DOI: 10.1016/0196-9781(93)90081-Q  0.302
1992 Lazure C, Benjannet S, Seidah NG, Chrétien M. Processed forms of neuroendocrine proteins 7B2 and secretogranin II are found in porcine pituitary extracts. International Journal of Peptide and Protein Research. 38: 392-400. PMID 1797712 DOI: 10.1111/J.1399-3011.1991.Tb01519.X  0.307
1992 Paquet L, Rondeau N, Seidah NG, Lazure C, Chrétien M, Mbikay M. Immunological identification and sequence characterization of a peptide derived from the processing of neuroendocrine protein 7B2. Febs Letters. 294: 23-6. PMID 1743287 DOI: 10.1016/0014-5793(91)81334-5  0.314
1992 Seidah NG, Day R, Hamelin J, Gaspar A, Collard MW, Chrétien M. Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase. Molecular Endocrinology (Baltimore, Md.). 6: 1559-70. PMID 1448111 DOI: 10.1210/Mend.6.10.1448111  0.351
1992 Gabreëls BA, Sonnemans MA, Seidah NG, Chrétien M, van Leeuwen FW. Dynamics of 7B2 and galanin expression in solitary magnocellular hypothalamic vasopressin neurons of the homozygous Brattleboro rat. Brain Research. 585: 275-82. PMID 1380870 DOI: 10.1016/0006-8993(92)91218-4  0.308
1992 Day R, Schafer MK, Watson SJ, Chrétien M, Seidah NG. Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary. Molecular Endocrinology (Baltimore, Md.). 6: 485-97. PMID 1316544 DOI: 10.1210/Mend.6.3.1316544  0.316
1991 Benjannet S, Rondeau N, Day R, Chrétien M, Seidah NG. PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proceedings of the National Academy of Sciences of the United States of America. 88: 3564-8. PMID 2023902 DOI: 10.1073/Pnas.88.9.3564  0.339
1991 Seidah NG, Marcinkiewicz M, Benjannet S, Gaspar L, Beaubien G, Mattei MG, Lazure C, Mbikay M, Chrétien M. Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Molecular Endocrinology (Baltimore, Md.). 5: 111-22. PMID 2017186 DOI: 10.1210/Mend-5-1-111  0.322
1991 Paquet L, Lazure C, Seidah NG, Chrétien M, Mbikay M. The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man. Biochemical and Biophysical Research Communications. 174: 156-62. PMID 1989596 DOI: 10.1016/0006-291X(91)90499-W  0.304
1991 Ladenheim RG, Seidah NG, Rougeon F. N-linked glycosylation affects the processing of mouse submaxillary gland prorenin in transfected AtT20 cells. European Journal of Biochemistry. 198: 535-40. PMID 1904027 DOI: 10.1111/J.1432-1033.1991.Tb16047.X  0.341
1991 Sawyer N, Rondeau N, Chrétien M, Seidah NG. Expression and sorting of rat plasma kallikrein in POMC-producing AtT-20 cells Dna and Cell Biology. 10: 259-269. PMID 1851425 DOI: 10.1089/Dna.1991.10.259  0.348
1990 Leduc R, Hendy GN, Seidah NG, Chrétien M, Lazure C. Fragmentation of bovine chromogranin A by plasma kallikrein. Life Sciences. 46: 1427-33. PMID 2345487 DOI: 10.1016/0024-3205(90)90458-4  0.342
1990 Seidah NG, Sawyer N, Hamelin J, Mion P, Beaubien G, Brachpapa L, Rochemont J, Mbikay M, Chretien M. Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species Dna and Cell Biology. 9: 737-748. PMID 2264928 DOI: 10.1089/Dna.1990.9.737  0.314
1990 Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M, Chrétien M. cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. Dna and Cell Biology. 9: 415-24. PMID 2169760 DOI: 10.1089/Dna.1990.9.415  0.314
1989 Linard CG, Mbikay M, Benjannet S, Lazure C, Seidah NG, Chrétien M. Correct processing and secretion of a human prostatic secretory protein (PSP94) in Escherichia coli. Gene. 73: 479-87. PMID 3072267 DOI: 10.1016/0378-1119(88)90512-4  0.316
1989 Paquin J, Benjannet S, Sawyer N, Lazure C, Chrétien M, Seidah NG. Rat plasma kallikrein: purification, NH2-terminal sequencing and development of a specific radioimmunoassay Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 999: 103-110. PMID 2597701 DOI: 10.1016/0167-4838(89)90206-9  0.31
1989 Chrétien M, Sikstrom RA, Lazure C, Mbikay M, Seidah NG. Functional diversity of bioactive peptides in the nervous system itself: “How the brain may understand” Bioscience Reports. 9: 693-700. PMID 2575404 DOI: 10.1007/Bf01114807  0.316
1989 Mbikay M, Grant SG, Sirois F, Tadros H, Skowronski J, Lazure C, Seidah NG, Hanahan D, Chrétien M. cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell tumors of transgenic mice. International Journal of Peptide and Protein Research. 33: 39-45. PMID 2542174 DOI: 10.1111/J.1399-3011.1989.Tb00681.X  0.323
1988 Benjannet S, Leduc R, Adrouche N, Falgueyret JP, Marcinkiewicz M, Seidah NG, Mbikay M, Lazure C, Chretien M. Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues. Febs Letters. 224: 142-8. PMID 3678488 DOI: 10.1016/0014-5793(87)80438-6  0.309
1988 Seidah NG, Paquin J, Hamelin J, Benjannet S, Chretien M. Structural and immunological homology of human and porcine pituitary and plasma IRCM-serine protease 1 to plasma kallikrein: marked selectivity for pairs of basic residues suggests a widespread role in pro-hormone and pro-enzyme processing Biochimie. 70: 33-46. PMID 2969754 DOI: 10.1016/0300-9084(88)90156-3  0.339
1987 Dubé JY, Frenette G, Paquin R, Chapdelaine P, Tremblay J, Tremblay RR, Lazure C, Seidah N, Chrétien M. Isolation from human seminal plasma of an abundant 16-kDa protein originating from the prostate, its identification with a 94-residue peptide originally described as beta-inhibin. Journal of Andrology. 8: 182-9. PMID 3610813 DOI: 10.1002/J.1939-4640.1987.Tb02429.X  0.302
1987 Lazure C, Leduc R, Seidah NG, Thibault G, Genest J, Chrétien M. The complete amino acid sequence of rat submaxillary gland tonin does contain the aspartic acid at the active site: confirmation by protein sequence analysis. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 65: 321-37. PMID 3038148 DOI: 10.1139/O87-042  0.309
1987 Seidah NG, Hendy GN, Hamelin J, Paquin J, Lazure C, Metters KM, Rossier J, Chrétien M. Chromogranin A can act as a reversible processing enzyme inhibitor. Evidence from the inhibition of the IRCM-serine protease 1 cleavage of pro-enkephalin and ACTH at pairs of basic amino acids. Febs Letters. 211: 144-50. PMID 3026846 DOI: 10.1016/0014-5793(87)81425-4  0.336
1987 Ong H, Lazure C, Nguyen TT, McNicoll N, Seidah N, Chrétien M, De Léan A. Bovine adrenal chromaffin granules are a site of synthesis of atrial natriuretic factor. Biochemical and Biophysical Research Communications. 147: 957-63. PMID 2959287 DOI: 10.1016/S0006-291X(87)80163-8  0.324
1987 Thibault G, Garcia R, Gutkowska J, Bilodeau J, Lazure C, Seidah NG, Chrétien M, Genest J, Cantin M. The propeptide Asn1-Tyr126 is the storage form of rat atrial natriuretic factor. The Biochemical Journal. 241: 265-72. PMID 2952112 DOI: 10.1042/Bj2410265  0.342
1986 Burbach JP, Seidah NG, Chrétien M. Isolation and primary structure of novel neurointermediate pituitary peptides derived from the C-terminal of the rat vasopressin-neurophysin precursor (propressophysin). European Journal of Biochemistry. 156: 137-42. PMID 3956504 DOI: 10.1111/J.1432-1033.1986.Tb09558.X  0.304
1986 Bennett HP, Seidah NG, Benjannet S, Solomon S, Chrétien M. Reinvestigation of the disulfide bridge arrangement in human pro-opiomelanocortin N-terminal segment (hNT 1-76). International Journal of Peptide and Protein Research. 27: 306-13. PMID 3519485 DOI: 10.1111/J.1399-3011.1986.Tb01825.X  0.307
1986 Seidah NG, Cromlish JA, Hamelin J, Thibault G, Chrétien M. Homologous IRCM-Serine Protease 1 from pituitary, heart atrium and ventricle: A common pro-hormone maturation enzyme? Bioscience Reports. 6: 835-844. PMID 3028526 DOI: 10.1007/Bf01117107  0.314
1986 Ong H, McNicoll N, Lazure C, Seidah N, Chrétien M, Cantin M, De Léan A. Purification and sequence determination of bovine atrial natriuretic factor. Life Sciences. 38: 1309-15. PMID 3007908 DOI: 10.1016/0024-3205(86)90425-X  0.315
1985 Benjannet S, Leduc R, Lazure C, Seidah NG, Marcinkiewicz M, Chrétien M. GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence. Biochemical and Biophysical Research Communications. 126: 602-9. PMID 3970711 DOI: 10.1016/0006-291X(85)90648-5  0.323
1985 Thibault G, Lazure C, Schiffrin EL, Gutkowska J, Chartier L, Garcia R, Seidah NG, Chrétien M, Genest J, Cantin M. Identification of a biologically active circulating form of rat atrial natriuretic factor. Biochemical and Biophysical Research Communications. 130: 981-6. PMID 3161512 DOI: 10.1016/0006-291X(85)91711-5  0.312
1985 Gutkowska J, Lazure C, Racz K, Thibault G, Garcia R, Seidah NG, Chrétien M, Genest J, Cantin M. ANF (Arg 101--Tyr 126) is the peptide secreted by rat atrial cardiocytes in culture. Biochemical and Biophysical Research Communications. 130: 1217-25. PMID 3161510 DOI: 10.1016/0006-291X(85)91744-9  0.312
1985 De Léan A, Thibault G, Seidah NG, Lazure C, Gutkowska J, Chrétien M, Genest J, Cantin M. Structure-activity relationships of atrial natriuretic factor (ANF). III. Correlation of receptor affinity with relative potency on aldosterone production in zona glomerulosa cells. Biochemical and Biophysical Research Communications. 132: 360-7. PMID 2998358 DOI: 10.1016/0006-291X(85)91030-7  0.304
1984 Seidah NG, Ramasharma K, Sairam MR, Chrétien M. Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity. Febs Letters. 167: 98-102. PMID 6698208 DOI: 10.1016/0014-5793(84)80840-6  0.323
1984 Seidah NG, Arbatti NJ, Rochemont J, Sheth AR, Chrétien M. Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site. Febs Letters. 175: 349-55. PMID 6434350 DOI: 10.1016/0014-5793(84)80766-8  0.334
1984 Lazure C, Leduc R, Seidah NG, Thibault G, Genest J, Chrétien M. Amino acid sequence of rat submaxillary tonin reveals similarities to serine proteases. Nature. 307: 555-558. PMID 6320014 DOI: 10.1038/307555A0  0.318
1984 Seidah NG, Lazure C, Chrétien M, Thibault G, Garcia R, Cantin M, Genest J, Nutt RF, Brady SF, Lyle TA. Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms. Proceedings of the National Academy of Sciences of the United States of America. 81: 2640-4. PMID 6232612 DOI: 10.1073/Pnas.81.9.2640  0.301
1984 Ramasharma K, Sairam MR, Seidah NG, Chrétien M, Manjunath P, Schiller PW, Yamashiro D, Choh Had LI. Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity Science. 223: 1202. DOI: 10.1126/Science.6422553  0.328
1983 Seidah NG, Pélaprat D, Lazure C, Chrétien M. Enzymatic cleavage of pro-opiomelanocortin by anterior pituitary granules. Evidence for a chymotryptic-like enzyme. Febs Letters. 159: 68-74. PMID 6873305 DOI: 10.1016/0014-5793(83)80418-9  0.309
1983 Hsi KL, Seidah NG, De Serres G, Chrétien M. Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60. Febs Letters. 147: 261-6. PMID 6816630 DOI: 10.1016/0014-5793(82)81055-7  0.306
1983 Seidah NG, Hsi KL, De Serres G, Rochemont J, Hamelin J, Antakly T, Cantin M, Chrétien M. Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus. Archives of Biochemistry and Biophysics. 225: 525-34. PMID 6625600 DOI: 10.1016/0003-9861(83)90063-2  0.328
1982 Boileau G, Larivière N, Hsi KL, Seidah NG, Chrétien M. Characterization of multiple forms of porcine anterior pituitary proopiomelanocortin amino-terminal glycopeptide Biochemistry. 21: 5341-5346. PMID 7171563 DOI: 10.1021/Bi00264A034  0.304
1982 Sairam MR, Seidah NG, Chrétien M. Primary structure of the ovine pituitary follitropin beta-subunit. The Biochemical Journal. 197: 541-52. PMID 6798969 DOI: 10.1042/Bj1970541  0.304
1982 Seidah NG, Rochemont J, Hamelin J, Benjannet S, Chrétien M. The missing fragment of the pro-sequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation. Biochemical and Biophysical Research Communications. 102: 710-6. PMID 6272808 DOI: 10.1016/S0006-291X(81)80190-8  0.312
1982 Watson SJ, Seidah NG, Chrétien M. The carboxy terminus of the precursor to vasopressin and neurophysin: immunocytochemistry in rat brain. Science (New York, N.Y.). 217: 853-5. PMID 6125034 DOI: 10.1126/Science.6125034  0.301
1981 Crine P, Seidah NG, Routhier R, Gossard F, Chrétien M. Processing of two forms of the common precursor to alpha-melanotropin and beta-endorphin in the rat pars intermedia. Evidence for and partial characterization of new pituitary peptides. European Journal of Biochemistry. 110: 387-96. PMID 7439167 DOI: 10.1111/J.1432-1033.1980.Tb04879.X  0.304
1981 Seidah NG, Benjannet S, Chrétien M. The complete sequence of a novel human pituitary glycopeptide homologous to pig posterior pituitary glycopeptide. Biochemical and Biophysical Research Communications. 100: 901-7. PMID 7271787 DOI: 10.1016/S0006-291X(81)80258-6  0.316
1981 Pelletier G, Leclerc R, Benjannet S, Seidah NG, Chrétien M. Immunohistochemical localization of gamma-melanocyte-stimulating hormone in the rat pituitary gland. Regulatory Peptides. 2: 81-9. PMID 7019988 DOI: 10.1016/0167-0115(81)90002-1  0.301
1981 Lazure C, Seidah NG, Thibault G, Boucher R, Genest J, Chrétien M. Sequence homologies between tonin, nerve growth factor gamma-subunit, epidermal growth factor-binding protein and serine proteases. Nature. 292: 383-384. PMID 6265796 DOI: 10.1038/292383A0  0.302
1981 Policastro P, Phillips M, Oates E, Herbert E, Roberts JL, Seidah N, Chrétien M. Evidence for a signal sequence at the N terminus of the common precursor to adrenocorticothrophin and beta-lipotropin in mouse pituitary cells. European Journal of Biochemistry / Febs. 116: 255-9. PMID 6166472 DOI: 10.1111/J.1432-1033.1981.Tb05327.X  0.304
1980 Seidah NG, Benjannet S, Routhier R, De Serres G, Rochemont J, Lis M, Chrétien M. Purification and characterization of the N-terminal fragment of pro-opiomelanocortin from human pituitaries: homology to the bovine sequence. Biochemical and Biophysical Research Communications. 95: 1417-24. PMID 7417326 DOI: 10.1016/S0006-291X(80)80055-6  0.315
1980 Benjannet S, Seidah NG, Routhier R, Chrétien M. A novel human pituitary peptide containing the γ-MSH sequence Nature. 285: 415-416. PMID 7189826 DOI: 10.1038/285415A0  0.322
1980 Gossard F, Seidah NG, Crine P, Routhier R, Chrétien M. Partial N-terminal amino acid sequence of pro-opio-melanocortin (ACTH/beta-LPH precursor) from rat pars intermedia. Biochemical and Biophysical Research Communications. 92: 1042-51. PMID 6244815 DOI: 10.1016/0006-291X(80)90807-4  0.309
1979 Scherrer H, Seidah NG, Renjannet S, Crine P, Lis M, Chrétien M. Biosynthesis of a ubiquitin-related peptide in rat brain and in human and mouse pituitary tumors. Biochemical and Biophysical Research Communications. 84: 874-85. PMID 728156 DOI: 10.1016/0006-291X(78)91665-0  0.317
1979 Seidah NG, Routhier R, Caron M, Chrétien M, Demassieux S, Boucher R, Genest J. N-Terminal amino acid sequence of rat tonin: homology with serine proteases. Canadian Journal of Biochemistry. 56: 920-5. PMID 215293 DOI: 10.1139/O78-142  0.302
1978 Seidah NG, Crine P, Benjannet S, Scherrer H, Chrétien M. Isolation and partial characterization of a biosynthetic N-terminal methionyl peptide of bovine pars intermedia: relationship to ubiquitin. Biochemical and Biophysical Research Communications. 80: 600-8. PMID 629794 DOI: 10.1016/0006-291X(78)91611-X  0.315
1978 Crine P, Benjannet S, Seidah NG, Lis M, Chrétien M. In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands. Proceedings of the National Academy of Sciences of the United States of America. 74: 4276-80. PMID 270671 DOI: 10.1073/Pnas.74.10.4276  0.303
1976 Chrétien M, Gilardeau C, Seidah N, Lis M. Purification and partial chemical characterization of human pituitary lipolytic hormone. Canadian Journal of Biochemistry. 54: 778-82. PMID 183879 DOI: 10.1139/O76-111  0.312
1974 de Levie R, Seidah NG. Transport of ions of one kind through thin membranes. 3. Current-voltage curves for membrane-soluble ions. The Journal of Membrane Biology. 16: 1-16. PMID 4837993 DOI: 10.1007/BF01872404  0.481
1974 De Levie R, Seidah N, Larkin D. Tetraphenylborate adsorption onto an artificial ultrathin membrane Journal of Electroanalytical Chemistry and Interfacial Electrochemistry. 49: 153-159. DOI: 10.1016/S0022-0728(74)80358-X  0.479
1974 de Levie R, Seidah NG, Moreira H. Transport of ions of one kind through thin membranes The Journal of Membrane Biology. 16: 17-42. DOI: 10.1007/BF01872405  0.482
1972 De Levie R, Seidah NG, Moreira H. Transport of ions of one kind through thin membranes. II. Nonequilibrium steady-state behavior. The Journal of Membrane Biology. 10: 171-92. PMID 4669446 DOI: 10.1007/BF01867852  0.481
Low-probability matches (unlikely to be authored by this person)
1997 Dong W, Seidel B, Marcinkiewicz M, Chrétien M, Seidah NG, Day R. Cellular Localization of the Prohormone Convertases in the Hypothalamic Paraventricular and Supraoptic Nuclei: Selective Regulation of PC1 in Corticotrophin-Releasing Hormone Parvocellular Neurons Mediated by Glucocorticoids The Journal of Neuroscience. 17: 563-575. DOI: 10.1523/Jneurosci.17-02-00563.1997  0.3
2013 Burri DJ, da Palma JR, Seidah NG, Zanotti G, Cendron L, Pasquato A, Kunz S. Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P). Journal of Virology. 87: 6406-14. PMID 23536681 DOI: 10.1128/Jvi.00072-13  0.3
1982 Larivière N, Seidah NG, Chrétien M. Complete sequence of the glycosylated amino terminal segment of porcine pro-opiomelanocortin. International Journal of Peptide and Protein Research. 18: 487-91. PMID 7341530 DOI: 10.1111/J.1399-3011.1981.Tb03010.X  0.3
2003 Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, Chrétien M, Seidah NG, Khatib AM. The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis Journal of Clinical Investigation. 111: 1723-1732. PMID 12782675 DOI: 10.1172/Jci17220  0.299
1986 Chan JS, Nie ZR, Seidah NG, Chrétien M. Purification of ovine placental lactogen (oPL) using high-performance liquid chromatography. Evidence for two forms of oPL. Febs Letters. 199: 259-64. PMID 3009220 DOI: 10.1016/0014-5793(86)80491-4  0.299
1984 Thibault G, Garcia R, Cantin M, Genest J, Lazure C, Seidah NG, Chrétien M. Primary structure of a high Mr form of rat atrial natriuretic factor. Febs Letters. 167: 352-6. PMID 6538144 DOI: 10.1016/0014-5793(84)80155-6  0.298
1995 Joshi D, Miller MM, Seidah NG, Day R. Age-related alterations in the expression of prohormone convertase messenger ribonucleic acid (mRNA) levels in hypothalamic proopiomelanocortin mRNA neurons in the female C57BL/6J mouse. Endocrinology. 136: 2721-9. PMID 7750497 DOI: 10.1210/Endo.136.6.7750497  0.298
2010 Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, LaFerla FM, Spencer TA, Hickey WF, Chang TY. ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proceedings of the National Academy of Sciences of the United States of America. 107: 3081-6. PMID 20133765 DOI: 10.1073/Pnas.0913828107  0.298
1985 Garcia R, Thibault G, Seidah NG, Lazure C, Cantin M, Genest J, Chrétien M. Structure-activity relationships of atrial natriuretic factor (ANF). II. Effect of chain-length modifications on vascular reactivity. Biochemical and Biophysical Research Communications. 126: 178-84. PMID 4038600 DOI: 10.1016/0006-291X(85)90588-1  0.298
2012 Bendjoudi A, Elchebly M, Emonnot L, Yara S, Ziv E, Seidah NG, Couture P, Seidman EG, Levy E. Su2009 PCSK9 Plays a Significant Role in Cholesterol Homeostasis and Lipid Transport in Intestinal Epithelial Cells Gastroenterology. 142: S-558-S-559. DOI: 10.1016/S0016-5085(12)62148-9  0.297
1981 Crine P, Lemieux E, Fortin S, Seidah NG, Lis M, Chrétien M. Expression of variant forms of proopiomelanocortin, the common precursor to corticotropin and β-lipotropin in the rat pars intermedia Biochemistry. 20: 2475-2481. PMID 6263313 DOI: 10.1021/Bi00512A018  0.297
1985 Lazure C, Rochemont J, Seidah NG, Chrétien M. Novel approach to rapid and sensitive localization of protein disulfide bridges by high-performance liquid chromatography and electrochemical detection Journal of Chromatography A. 326: 339-348. DOI: 10.1016/S0021-9673(01)87459-8  0.297
2012 Kim W, Essalmani R, Szumska D, Creemers JW, Roebroek AJ, D'Orleans-Juste P, Bhattacharya S, Seidah NG, Prat A. Loss of endothelial furin leads to cardiac malformation and early postnatal death. Molecular and Cellular Biology. 32: 3382-91. PMID 22733989 DOI: 10.1128/Mcb.06331-11  0.297
1997 Farhadi H, Pareek S, Day R, Dong W, Chrétien M, Bergeron JJ, Seidah NG, Murphy RA. Prohormone convertases in mouse submandibular gland: co-localization of furin and nerve growth factor. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 45: 795-804. PMID 9199665 DOI: 10.1177/002215549704500604  0.297
2007 Mayne J, Raymond A, Chaplin A, Cousins M, Kaefer N, Gyamera-Acheampong C, Seidah NG, Mbikay M, Chrétien M, Ooi TC. Plasma PCSK9 levels correlate with cholesterol in men but not in women. Biochemical and Biophysical Research Communications. 361: 451-6. PMID 17645871 DOI: 10.1016/J.Bbrc.2007.07.029  0.297
1985 Thibault G, Garcia R, Carrier F, Seidah NG, Lazure C, Chrétien M, Cantin M, Genest J. Structure-activity relationships of atrial natriuretic factor (ANF). I. Natriuretic activity and relaxation of intestinal smooth muscle. Biochemical and Biophysical Research Communications. 125: 938-46. PMID 6542779 DOI: 10.1016/0006-291X(84)91374-3  0.297
2011 Rousselet E, Marcinkiewicz J, Kriz J, Zhou A, Hatten ME, Prat A, Seidah NG. PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke. Journal of Lipid Research. 52: 1383-91. PMID 21518694 DOI: 10.1194/Jlr.M014118  0.297
1977 Chrétien M, Seidah NG, Benjannet S, Dragon N, Routhier R, Motomatsu T, Crine P, Lis M. A betaLPH precursor model: recent developments concerning morphine-like substances. Annals of the New York Academy of Sciences. 297: 84-107. PMID 279264 DOI: 10.1111/J.1749-6632.1977.Tb41847.X  0.297
1995 Jean F, Basak A, DiMaio J, Seidah NG, Lazure C. An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor. The Biochemical Journal. 689-95. PMID 7741698 DOI: 10.1042/Bj3070689  0.297
1981 Crine P, Seidah NG, Jeannotte L, Chrétien M. Two large glycoprotein fragments related to the NH2-terminal part of the adrenocorticotropin-beta-lipotropin precursor are the end products of the maturation process in the rat pars intermedia. Canadian Journal of Biochemistry. 58: 1318-22. PMID 7214198 DOI: 10.1139/O80-179  0.296
2012 Burri DJ, Pasqual G, Rochat C, Seidah NG, Pasquato A, Kunz S. Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease. Journal of Virology. 86: 4935-46. PMID 22357276 DOI: 10.1128/Jvi.00024-12  0.296
1982 Chan JS, Lu CL, Seidah NG, Chretien M. Corticotropin releasing factor (CRF): effects on the release of pro-opiomelanocortin (POMC)-related peptides by human anterior pituitary cells in vitro. Endocrinology. 111: 1388-90. PMID 6288359 DOI: 10.1210/Endo-111-4-1388  0.296
2004 Pullikotil P, Vincent M, Nichol ST, Seidah NG. Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: Processing of SREBP-2, ATF6, and a viral glycoprotein Journal of Biological Chemistry. 279: 17338-17347. PMID 14970232 DOI: 10.1074/Jbc.M313764200  0.296
1999 Wouters S, Decroly E, Vandenbranden M, Shober D, Fuchs R, Morel V, Leruth M, Seidah NG, Courtoy PJ, Ruysschaert JM. Occurrence of an HIV-1 gp160 endoproteolytic activity in low-density vesicles and evidence for a distinct density distribution from endogenously expressed furin and PC7/LPC convertases. Febs Letters. 456: 97-102. PMID 10452538 DOI: 10.1016/S0014-5793(99)00938-2  0.296
1980 Seidah NG, Routhier R, Benjannet S, Larivière N, Gossard F, Chrétien M. Reversed-phase high-performance liquid chromatographic purification and characterization of the adrenocorticotropin/lipotropin precursor and its fragments. Journal of Chromatography. 193: 291-9. PMID 6248573 DOI: 10.1016/S0021-9673(00)81498-3  0.296
2005 Nour N, Mayer G, Mort JS, Salvas A, Mbikay M, Morrison CJ, Overall CM, Seidah NG. The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases Molecular Biology of the Cell. 16: 5215-5226. PMID 16135528 DOI: 10.1091/Mbc.E05-06-0504  0.296
1990 Basak A, Gong YT, Cromlish JA, Paquin JA, Jean F, Seidah NG, Lazure C, Chretien M. Syntheses of argininal semicarbazone containing peptides and their applications in the affinity chromatography of serine proteinases International Journal of Peptide and Protein Research. 36: 7-17. PMID 2401601 DOI: 10.1111/J.1399-3011.1990.Tb00078.X  0.296
2014 Scamuffa N, Sfaxi F, Ma J, Lalou C, Seidah N, Calvo F, Khatib AM. Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis. Carcinogenesis. 35: 528-36. PMID 24127186 DOI: 10.1093/Carcin/Bgt345  0.296
2002 Khatib AM, Siegfried G, Chrétien M, Metrakos P, Seidah NG. Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy. The American Journal of Pathology. 160: 1921-35. PMID 12057895 DOI: 10.1016/S0002-9440(10)61140-6  0.296
2016 Anyetei-Anum EN, Blum A, Seidah NG, Beinfeld MC. Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain. Biochemical and Biophysical Research Communications. PMID 27923657 DOI: 10.1016/J.Bbrc.2016.12.010  0.295
1984 Lazure C, Seidah NG, Chrétien M, Thibault G, Garcia R, Cantin M, Genest J. Atrial pronatriodilatin: a precursor for natriuretic factor and cardiodilatin. Amino acid sequence evidence. Febs Letters. 172: 80-6. PMID 6547393 DOI: 10.1016/0014-5793(84)80878-9  0.295
1981 Chrétien M, Seidah NG, Scherrer H. Endorphines: structure, rôles et biogénèse Canadian Journal of Physiology and Pharmacology. 59: 413-431. DOI: 10.1139/Y81-066  0.294
1994 Laslop A, Mahata SK, Wolkersdorfer M, Mahata M, Srivastava M, Seidah NG, Fischer-Colbrie R, Winkler H. Large dense-core vesicles in rat adrenal after reserpine: levels of mRNAs of soluble and membrane-bound constituents in chromaffin and ganglion cells indicate a biosynthesis of vesicles with higher secretory quanta. Journal of Neurochemistry. 62: 2448-56. PMID 8189248 DOI: 10.1046/J.1471-4159.1994.62062448.X  0.294
2013 Seidah NG. Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors in the treatment of hypercholesterolemia and other pathologies. Current Pharmaceutical Design. 19: 3161-72. PMID 23317404 DOI: 10.2174/13816128113199990313  0.294
1988 Thibault G, Murthy KK, Gutkowska J, Seidah NG, Lazure C, Chrétien M, Cantin M. NH2-terminal fragment of rat pro-atrial natriuretic factor in the circulation: identification, radioimmunoassay and half-life. Peptides. 9: 47-53. PMID 2966345 DOI: 10.1016/0196-9781(88)90008-3  0.294
2013 Pasquato A, Ramos da Palma J, Galan C, Seidah NG, Kunz S. Viral envelope glycoprotein processing by proprotein convertases. Antiviral Research. 99: 49-60. PMID 23611717 DOI: 10.1016/J.Antiviral.2013.04.013  0.293
2018 Ashraf Y, Sachan V, Essalmani R, Duval S, Marcinkiewicz J, Hamelin J, Roubtsova A, Prat A, Seidah NG. The Proprotein Convertase 7 Regulates Triglyceride Levels via Enhanced ApoA5 Degradation Atherosclerosis Supplements. 32: 56. DOI: 10.1016/J.Atherosclerosissup.2018.04.169  0.293
2011 Marchesi C, Essalmani R, Lemarié CA, Leibovitz E, Ebrahimian T, Paradis P, Seidah NG, Schiffrin EL, Prat A. Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy. Journal of Molecular Medicine (Berlin, Germany). 89: 1103-11. PMID 21681612 DOI: 10.1007/S00109-011-0776-9  0.293
1984 Ninomiya Y, Showalter AM, Van Der Rest M, Seidah NG, Chrétien M, Olsen BR. Structure of the carboxyl propeptide of chicken type II procollagen determined by DNA and protein sequence analysis Biochemistry. 23: 617-624. DOI: 10.1021/Bi00299A005  0.292
1976 Chrétien M, Benjannet S, Dragon N, Seidah NG, Lis M. Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin. Biochemical and Biophysical Research Communications. 72: 472-8. PMID 985493 DOI: 10.1016/S0006-291X(76)80066-6  0.292
1987 Falgueyret JP, Marcinkiewicz M, Benjannet S, Cantin M, Seidah NG, Chrétien M. Immunocytochemical localization of a novel pituitary polypeptide "7B2" in the gastro-intestinal tract of the rat. Cell and Tissue Research. 249: 707-709. PMID 3311380 DOI: 10.1007/Bf00217343  0.292
2001 Dubois CM, Blanchette F, Laprise MH, Leduc R, Grondin F, Seidah NG. Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme. The American Journal of Pathology. 158: 305-16. PMID 11141505 DOI: 10.1016/S0002-9440(10)63970-3  0.292
1999 Mowla SJ, Pareek S, Farhadi HF, Petrecca K, Fawcett JP, Seidah NG, Morris SJ, Sossin WS, Murphy RA. Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2069-80. PMID 10066260 DOI: 10.1523/Jneurosci.19-06-02069.1999  0.292
2020 Garçon D, Moreau F, Ayer A, Dijk W, Prieur X, Arnaud L, Roubtsova A, Seidah N, Prat A, Cariou B, Le May C. Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314194. PMID 32673528 DOI: 10.1161/Atvbaha.120.314194  0.291
1987 Marcinkiewicz M, Benjannet S, Seidah NG, Cantin M, Chrétien M. The pituitary polypeptide "7B2" is associated with LH/FSH and TSH cells and is localized within secretory vesicles. Cell and Tissue Research. 250: 205-214. PMID 3115588 DOI: 10.1007/Bf00214673  0.291
1984 Lazure C, Leduc R, Seidah NG, Chrétien M, Dubé JY, Chapdelaine P, Frenette G, Paquin R, Tremblay RR. The major androgen-dependent protease in dog prostate belongs to the kallikrein family: confirmation by partial amino acid sequencing. Febs Letters. 175: 1-7. PMID 6566614 DOI: 10.1016/0014-5793(84)80557-8  0.291
2003 Bergeron E, Basak A, Decroly E, Seidah NG. Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage. The Biochemical Journal. 373: 475-84. PMID 12691605 DOI: 10.1042/Bj20021630  0.291
2011 Pasquato A, Burri DJ, Traba EG, Hanna-El-Daher L, Seidah NG, Kunz S. Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease. Virology. 417: 18-26. PMID 21612810 DOI: 10.1016/J.Virol.2011.04.021  0.291
2002 Basak A, Chrétien M, Seidah NG. A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus. Febs Letters. 514: 333-9. PMID 11943176 DOI: 10.1016/S0014-5793(02)02394-3  0.29
1997 Cheng M, Watson P, Paterson J, Seidah N, Chrétien M, Shiu RPC. Pro-protein convertase gene expression in human breast cancer. International Journal of Cancer. 71: 966-971. PMID 9185698 DOI: 10.1002/(Sici)1097-0215(19970611)71:6<966::Aid-Ijc10>3.0.Co;2-4  0.29
1997 Mbikay M, Sirois F, Yao J, Seidah NG, Chrétien M. Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours British Journal of Cancer. 75: 1509-1514. PMID 9166946 DOI: 10.1038/Bjc.1997.258  0.29
2012 Richard C, Couture P, Desroches S, Benjannet S, Seidah NG, Lichtenstein AH, Lamarche B. Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome. The British Journal of Nutrition. 107: 705-11. PMID 21787450 DOI: 10.1017/S0007114511003436  0.29
1984 Gaspar L, Chan JS, Seidah NG, Chrétien M. Urinary molecular forms of human N-terminal of proopiomelanocortin: possible deglycosylation and degradation by the kidney. The Journal of Clinical Endocrinology and Metabolism. 59: 614-21. PMID 6480799 DOI: 10.1210/Jcem-59-4-614  0.29
2005 Tzimas GN, Chevet E, Jenna S, Nguyên DT, Khatib AM, Marcus V, Zhang Y, Chrétien M, Seidah N, Metrakos P. Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases. Bmc Cancer. 5: 149. PMID 16293189 DOI: 10.1186/1471-2407-5-149  0.29
1980 Crine P, Gossard F, Seidah NG, Blanchette L, Lis M, Chrétien M. Concomitant synthesis of beta-endorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia. Proceedings of the National Academy of Sciences of the United States of America. 76: 5085-9. PMID 228277 DOI: 10.1073/Pnas.76.10.5085  0.29
1988 Marcinkiewicz M, Fischer-Colbrie R, Falgueyret JP, Benjannet S, Seidah NG, Lazure C, Winkler H, Chrétien M. Two-dimensional immunoblotting analysis and immunocytochemical localization of the secretory polypeptide 7B2 in adrenal medulla. Neuroscience Letters. 95: 81-87. PMID 3226625 DOI: 10.1016/0304-3940(88)90636-2  0.29
1998 Seidah NG, Day R, Marcinkiewicz M, Chrétien M. Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins. Annals of the New York Academy of Sciences. 839: 9-24. PMID 9629127 DOI: 10.1111/J.1749-6632.1998.Tb10727.X  0.29
2017 El-Rifai O, Chow J, Lacombe J, Julien C, Faubert D, Susan-Resiga D, Essalmani R, Creemers JW, Seidah NG, Ferron M. Proprotein convertase furin regulates osteocalcin and bone endocrine function. The Journal of Clinical Investigation. PMID 28972540 DOI: 10.1172/Jci93437  0.289
2019 Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, et al. Site-specific -glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. The Journal of Biological Chemistry. 294: 8349. PMID 31127061 DOI: 10.1074/Jbc.Aac119.009121  0.289
2000 Farhadi HF, Mowla SJ, Petrecca K, Morris SJ, Seidah NG, Murphy RA. Neurotrophin-3 Sorts to the Constitutive Secretory Pathway of Hippocampal Neurons and Is Diverted to the Regulated Secretory Pathway by Coexpression with Brain-Derived Neurotrophic Factor The Journal of Neuroscience. 20: 4059-4068. DOI: 10.1523/Jneurosci.20-11-04059.2000  0.289
2012 Guillemot J, Thouënnon E, Guérin M, Vallet-Erdtmann V, Ravni A, Montéro-Hadjadje M, Lefebvre H, Klein M, Muresan M, Seidah NG, Anouar Y, Yon L. Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66. Journal of Molecular Endocrinology. 48: 115-27. PMID 22217803 DOI: 10.1530/Jme-11-0077  0.289
2004 Nejjari M, Berthet V, Rigot V, Laforest S, Jacquier MF, Seidah NG, Remy L, Bruyneel E, Scoazec JY, Marvaldi J, Luis J. Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model American Journal of Pathology. 164: 1925-1933. PMID 15161629 DOI: 10.1016/S0002-9440(10)63753-4  0.289
2016 Raal FJ, Giugliano RP, Sabatine MS, Koren MJ, Blom D, Seidah NG, Honarpour N, Lira A, Xue A, Chirovolu P, Jackson S, Di M, Peach M, Somaratne R, Wasserman SM, et al. PCSK9 inhibition-mediated reduction in Lp(a) with evolocumab: an analysis of 10 clinical trials and the role of the LDL receptor. Journal of Lipid Research. PMID 27102113 DOI: 10.1194/Jlr.P065334  0.288
2019 Chong M, Yoon G, Susan-Resiga D, Chamberland A, Cheillan D, Paré G, Seidah NG. Hypolipidaemia among patients with PMM2-CDG is associated with low circulating PCSK9 levels: a case report followed by observational and experimental studies. Journal of Medical Genetics. PMID 31391289 DOI: 10.1136/Jmedgenet-2019-106102  0.288
1985 Arbatti NJ, Seidah NG, Rochemont J, Escher E, Sheth AR, Chrétien M. beta 2-Inhibin contains the active core of human seminal plasma beta-inhibin: synthesis and bioactivity. Febs Letters. 181: 57-63. PMID 3918887 DOI: 10.1016/0014-5793(85)81113-3  0.288
1980 Chan JS, Seidah NG, Gianoulakis C, Bélanger A, Chrétien M. Chemical characterization of adrenocorticotropin and a novel peptide biosynthesized from a pituitary adenoma of a patient with Cushing's disease. The Journal of Clinical Endocrinology and Metabolism. 51: 364-7. PMID 6249839 DOI: 10.1210/Jcem-51-2-364  0.288
2018 Seidah NG, Chrétien M, Mbikay M. The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation. Current Opinion in Lipidology. PMID 29342010 DOI: 10.1097/Mol.0000000000000484  0.288
2017 Coriati A, Arslanian E, Bouvet GF, Prat A, Seidah NG, Rabasa-Lhoret R, Berthiaume Y. Proprotein Convertase Subtilisin/Kexin type 9 affects insulin but not lipid metabolism in cystic fibrosis. Clinical and Investigative Medicine. Medecine Clinique Et Experimentale. 40: E59-E65. PMID 28447578 DOI: 10.25011/Cim.V40I2.28196  0.287
2016 Koschinsky M, Gemin M, Scipione C, Boffa M, Seidah N, Romagnuolo R. Evaluating The Roles Of PCSK9 And Specific Receptors In Lipoprotein(A) Catabolism Journal of Clinical Lipidology. 10: 720-721. DOI: 10.1016/J.Jacl.2016.03.099  0.287
2001 Bahbouhi B, Seidah NG, Bahraoui E. Replication of HIV-1 viruses in the presence of the Portland alpha1-antitrypsin variant (alpha1-PDX) inhibitor. Biochemical Journal. 360: 127-134. PMID 11695999 DOI: 10.1042/0264-6021:3600127  0.286
1979 Crine P, Gianoulakis C, Seidah NG, Gossard F, Pezalla PD, Lis M, Chrétien M. Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia. Proceedings of the National Academy of Sciences of the United States of America. 75: 4719-23. PMID 216997 DOI: 10.1073/Pnas.75.10.4719  0.286
1984 Thibault G, Garcia R, Seidah NG, Lazure C, Cantin M, Chrétien M, Genest J. Purification of three rat atrial natriuretic factors and their amino acid composition. Febs Letters. 164: 286-90. PMID 6686159 DOI: 10.1016/0014-5793(83)80303-2  0.286
2013 Jänis MT, Tarasov K, Ta HX, Suoniemi M, Ekroos K, Hurme R, Lehtimäki T, Päivä H, Kleber ME, März W, Prat A, Seidah NG, Laaksonen R. Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency. Atherosclerosis. 228: 380-5. PMID 23623011 DOI: 10.1016/J.Atherosclerosis.2013.03.029  0.286
2001 Cheng M, Xu N, Iwasiow B, Seidah N, Chrétien M, Shiu RP. Elevated expression of proprotein convertases alters breast cancer cell growth in response to estrogen and tamoxifen. Journal of Molecular Endocrinology. 26: 95-105. PMID 11241161 DOI: 10.1677/Jme.0.0260095  0.286
2017 Gangloff A, Calon F, Seidah NG. Can iPCSK9-induced hypocholesterolemia starve cancer cells? Journal of Clinical Lipidology. 11: 600-601. PMID 28506383 DOI: 10.1016/J.Jacl.2017.04.001  0.286
1982 Lis M, Larivière N, Maurice G, Julesz J, Seidah N, Chrétien M. Concomitant changes of ACTH, β-endorphin and N-terminal portion of pro-opiomelanocortin in rats Life Sciences. 30: 1159-1164. PMID 6283283 DOI: 10.1016/0024-3205(82)90657-9  0.285
1977 Dragon N, Seidah NG, Lis M, Routhier R, Chrétien M. Primary structure and morphine-like activity of human beta-endorphin. Canadian Journal of Biochemistry. 55: 666-70. PMID 195688 DOI: 10.1139/O77-096  0.285
2009 Labonté P, Begley S, Guévin C, Asselin MC, Nassoury N, Mayer G, Prat A, Seidah NG. PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression. Hepatology (Baltimore, Md.). 50: 17-24. PMID 19489072 DOI: 10.1002/Hep.22911  0.284
2012 Laaksonen R, Tarasov K, Ta HX, Ekroos K, Hurme R, Lehtimäki T, Päivä H, Kleber ME, März W, Prat A, Seidah NG, Jänis MT. Molecular Lipids Provide More Information on PCSK9 Deficiency Than LDL-Cholesterol Journal of Clinical Lipidology. 6: 284. DOI: 10.1016/J.Jacl.2012.04.062  0.284
1998 Gabreëls BA, Swaab DF, de Kleijn DP, Seidah NG, Van de Loo JW, Van de Ven WJ, Martens GJ, van Leeuwen FW. Attenuation of the polypeptide 7B2, prohormone convertase PC2, and vasopressin in the hypothalamus of some Prader-Willi patients: indications for a processing defect. The Journal of Clinical Endocrinology and Metabolism. 83: 591-9. PMID 9467579 DOI: 10.1210/Jcem.83.2.4542  0.283
1986 Chan JS, Deng JY, Brar AK, Seidah NG, Chrétien M. Inhibition of release of a novel pituitary polypeptide, 7B2, follicle-stimulating hormone, and luteinizing hormone from rat anterior pituitary cells in vitro by human beta-inhibin. Canadian Journal of Physiology and Pharmacology. 64: 1259-62. PMID 3096547 DOI: 10.1139/Y86-212  0.283
1980 Chrétien M, Benjannet S, Gossard F, Gianoulakis C, Crine P, Lis M, Seidah NG. From beta-lipotropin to beta-endorphin and 'pro-opio-melanocortin'. Canadian Journal of Biochemistry. 57: 1111-21. PMID 228824 DOI: 10.1139/O79-143  0.283
2013 Hipp MM, Shepherd D, Gileadi U, Aichinger MC, Kessler BM, Edelmann MJ, Essalmani R, Seidah NG, Reis e Sousa C, Cerundolo V. Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes. Immunity. 39: 711-21. PMID 24138882 DOI: 10.1016/J.Immuni.2013.09.004  0.283
1995 Basak A, Jean F, Seidah NG, Lazure C. Design and synthesis of novel inhibitors of prohormone convertases. International Journal of Peptide and Protein Research. 44: 253-61. PMID 7822102 DOI: 10.1111/J.1399-3011.1994.Tb00168.X  0.283
2016 Elbitar S, Khoury PE, Ghaleb Y, Rabès JP, Varret M, Seidah NG, Boileau C, Abifadel M. Proprotein convertase subtilisin / kexin 9 (PCSK9) inhibitors and the future of dyslipidemia therapy: an updated patent review (2011-2015). Expert Opinion On Therapeutic Patents. PMID 27359211 DOI: 10.1080/13543776.2016.1206080  0.282
2015 Le Coupanec A, Desforges M, Meessen-Pinard M, Dubé M, Day R, Seidah NG, Talbot PJ. Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System. Plos Pathogens. 11: e1005261. PMID 26545254 DOI: 10.1371/Journal.Ppat.1005261  0.282
1995 Milhiet PE, Chevallier S, Corbeil D, Seidah NG, Crine P, Boileau G. Proteolytic processing of the alpha-subunit of rat endopeptidase-24.18 by furin. The Biochemical Journal. 309: 683-8. PMID 7626036 DOI: 10.1042/Bj3090683  0.282
1977 Seidah NG, Lis M, Gianoulakis C, Routhier R, Benjannet S, Schiller PW, Chretien M. Morphine-like activity of sheep beta-lipotropin and of its tryptic fragments. Canadian Journal of Biochemistry. 55: 35-40. PMID 837244 DOI: 10.1139/O77-006  0.281
1977 Kan KW, Baird A, Seidah NG, Lis M, Chrétien M, Ling N, Guillemin R, Solomon S. Effects of peptides of pituitary origin on the formation of C21 steroid by fetal calf adrenal cells in culture. Biochemical and Biophysical Research Communications. 79: 553-60. PMID 201254 DOI: 10.1016/0006-291X(77)90193-0  0.281
1986 Deng JY, Chan JS, Seidah NG, Chrétien M. Specific release of a novel pituitary polypeptide, 7B2, from rat anterior pituitary cells in vitro by luteinizing hormone-releasing hormone. Neuroendocrinology. 44: 373-7. PMID 3100976 DOI: 10.1159/000124671  0.281
2009 Sun X, Essalmani R, Seidah NG, Prat A. The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model. Molecular Cancer. 8: 73. PMID 19737405 DOI: 10.1186/1476-4598-8-73  0.28
1977 Seidah NG, Dragon N, Benjannet S, Routhier R, Crétien. The complete sequence of sheep beta-endorphin. Biochemical and Biophysical Research Communications. 74: 1528-35. PMID 843377 DOI: 10.1016/0006-291X(77)90616-7  0.28
2016 Guillemot J, Asselin M, Susan‐Resiga D, Essalmani R, Seidah NG. Back cover: Deferoxamine stimulates LDLR expression and LDL uptake in HepG2 cells Molecular Nutrition & Food Research. 60. DOI: 10.1002/Mnfr.201670035  0.28
2003 Tadros H, Seidah NG, Chrétien M, Mbikay M. Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8. Dna Sequence : the Journal of Dna Sequencing and Mapping. 13: 109-11. PMID 12180344 DOI: 10.1080/10425170290030042  0.279
2002 Bahbouhi B, Chazal N, Seidah NG, Chiva C, Kogan M, Albericio F, Giralt E, Bahraoui E. Effects of L- and D-REKR amino acid-containing peptides on HIV and SIV envelope glycoprotein precursor maturation and HIV and SIV replication. The Biochemical Journal. 366: 863-72. PMID 12071862 DOI: 10.1042/Bj20020052  0.279
2006 Seidah NG. Unexpected similarity between the cytosolic West Nile virus NS3 and the secretory furin-like serine proteinases The Biochemical Journal. 393. PMID 16371006 DOI: 10.1042/Bj20051787  0.279
1991 MBIKAY M, BENJANNET S, GIANOULAKIS C, SEIDAH N, CHRETIEN M. The messenger RNA for pituitary protein 7B2 is widely expressed in mouse CNS and castration reduces its pituitary level Neurochemistry International. 19: 103-111. DOI: 10.1016/0197-0186(91)90125-W  0.278
2007 Lapierre M, Siegfried G, Scamuffa N, Bontemps Y, Calvo F, Seidah NG, Khatib AM. Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: Role of tissue inhibitors of metalloproteinase-1 Cancer Research. 67: 9030-9034. PMID 17909005 DOI: 10.1158/0008-5472.Can-07-0807  0.278
1993 Day R, Schafer MK, Cullinan WE, Watson SJ, Chrétien M, Seidah NG. Region specific expression of furin mRNA in the rat brain. Neuroscience Letters. 149: 27-30. PMID 8469374 DOI: 10.1016/0304-3940(93)90339-M  0.277
2013 Krastins B, Prakash A, Sarracino DA, Nedelkov D, Niederkofler EE, Kiernan UA, Nelson R, Vogelsang MS, Vadali G, Garces A, Sutton JN, Peterman S, Byram G, Darbouret B, Pérusse JR, ... Seidah NG, et al. Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum. Clinical Biochemistry. 46: 399-410. PMID 23313081 DOI: 10.1016/J.Clinbiochem.2012.12.019  0.277
2009 Gorski JP, Huffman NT, Cui C, Henderson EP, Midura RJ, Seidah NG. Potential role of proprotein convertase SKI-1 in the mineralization of primary bone. Cells, Tissues, Organs. 189: 25-32. PMID 18728345 DOI: 10.1159/000151723  0.277
2017 Di Filippo M, Vokaer B, Seidah NG. A case of hypocholesterolemia and steatosis in a carrier of a PCSK9 loss-of-function mutation and polymorphisms predisposing to nonalcoholic fatty liver disease. Journal of Clinical Lipidology. PMID 28711549 DOI: 10.1016/J.Jacl.2017.06.005  0.276
1988 Lattion AL, Baussant T, Alhenc-Gelas F, Seidah NG, Corvol P, Soubrier F. The high-molecular-mass kininogen deficient rat expresses all kininogen mRNA species, but does not export the high-molecular-mass kininogen synthesized. Febs Letters. 239: 59-64. PMID 3181425 DOI: 10.1016/0014-5793(88)80545-3  0.275
1989 Bertagna X, Seidah N, Massias JF, Lenne F, Luton JP, Girard F, Chretien M. Microsequencing evidence for the maturation of human proopiomelanocortin into an 18 amino acid beta-melanocyte stimulating hormone [h beta MSH(5-22)] in nonpituitary tissue. Peptides. 10: 83-7. PMID 2748427 DOI: 10.1016/0196-9781(89)90081-8  0.275
1983 Dennis M, Lazure C, Seidah NG, Chrétien M. Characterization of beta-endorphin immunoreactive peptides in rat pituitary and brain by coupled gel and reversed-phase high-performance liquid chromatography. Journal of Chromatography. 266: 163-72. PMID 6313717 DOI: 10.1016/S0021-9673(01)90889-1  0.275
1983 Cantin M, Ballak M, Lu CL, Seidah NG, Chrétien M. Corticotropin (ACTH) and the N-terminal fragment of pro-opiomelanocortin are located in the same granules in cells of rat pituitary gland. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 31: 479-87. PMID 6298307 DOI: 10.1177/31.4.6298307  0.275
1987 Iguchi H, Chan JS, Seidah NG, Chrétien M. Evidence for a novel pituitary protein (7B2) in human brain, cerebrospinal fluid and plasma: brain concentrations in controls and patients with Alzheimer's disease. Peptides. 8: 593-8. PMID 3628077 DOI: 10.1016/0196-9781(87)90030-1  0.274
2011 Prat A, Behrendt M, Marcinkiewicz E, Boridy S, Sairam RM, Seidah NG, Maysinger D. A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy. Journal of Aging Research. 2011: 251517. PMID 21969914 DOI: 10.4061/2011/251517  0.274
1991 Beaubien G, Rosinski-Chupin I, Mattei MG, Mbikay M, Chrétien M, Seidah NG. Gene structure and chromosomal localization of plasma kallikrein. Biochemistry. 30: 1628-35. PMID 1993180 DOI: 10.1021/Bi00220A027  0.273
1986 Marcinkiewicz M, Benjannet S, Cantin M, Seidah NG, Chrétien M. CNS distribution of a novel pituitary protein '7B2': localization in secretory and synaptic vesicles. Brain Research. 380: 349-56. PMID 3530373 DOI: 10.1016/0006-8993(86)90233-7  0.273
2017 Çaku A, Seidah NG, Lortie A, Gagné N, Perron P, Dubé J, Corbin F. New insights of altered lipid profile in Fragile X Syndrome. Plos One. 12: e0174301. PMID 28334053 DOI: 10.1371/Journal.Pone.0174301  0.273
2017 Varret M, Abifadel M, Despina Kalopissis A, Fatoumata Maiga S, Lambert G, Seidah NG, Boileau C, Chabert M. Effect of the p.Arg357His mutation of PCSK9 on basal and postprandial lipoprotein metabolism. Atherosclerosis. 263: e2. PMID 29365771 DOI: 10.1016/J.Atherosclerosis.2017.06.036  0.273
1986 Chan JS, Nie ZR, Seidah NG, Chrétien M. Binding inhibition by monoclonal antibodies of ovine placental lactogen to growth hormone receptors in human liver. Febs Letters. 201: 168-72. PMID 3011504 DOI: 10.1016/0014-5793(86)80592-0  0.272
1997 Benjannet S, Savaria D, Laslop A, Munzer JS, Chrétien M, Marcinkiewicz M, Seidah NG. Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway. The Journal of Biological Chemistry. 272: 26210-8. PMID 9334189 DOI: 10.1074/Jbc.272.42.26210  0.272
1997 Decroly E, Wouters S, Di Bello C, Lazure C, Ruysschaert JM, Seidah NG. Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines. The Journal of Biological Chemistry. 271: 30442-50. PMID 8940009 DOI: 10.1074/Jbc.271.48.30442  0.272
1980 Herbert E, Budarf M, Phillips M, Rosa P, Policastro P, Oates E, Roberts JL, Seidah NG, Chrétien M. Presence of a pre-sequence (signal sequence) in the common precursor to ACTH and endorphin and the role of glycosylation in processing of the precursor and secretion of ACTH and endorphin. Annals of the New York Academy of Sciences. 343: 79-93. PMID 6249168 DOI: 10.1111/J.1749-6632.1980.Tb47244.X  0.272
2018 Elbitar S, Susan-Resiga D, Ghaleb Y, El Khoury P, Peloso G, Stitziel N, Rabès JP, Carreau V, Hamelin J, Ben-Djoudi-Ouadda A, Bruckert E, Boileau C, Seidah NG, Varret M, Abifadel M. New Sequencing technologies help revealing unexpected mutations in Autosomal Dominant Hypercholesterolemia. Scientific Reports. 8: 1943. PMID 29386597 DOI: 10.1038/S41598-018-20281-9  0.272
2004 Veinot JP, Prichett-Pejic W, Picard P, Parks W, Schwartz R, Seidah NG, Chretien M. Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model Cardiovascular Pathology. 13: 241-250. PMID 15358338 DOI: 10.1016/J.Carpath.2004.05.004  0.271
2002 Marcinkiewicz M, Seidah NG. Coordinated Expression of β‐Amyloid Precursor Protein and the Putative β‐Secretase BACE and α‐Secretase ADAM10 in Mouse and Human Brain Journal of Neurochemistry. 75: 2133-2143. PMID 11032903 DOI: 10.1046/J.1471-4159.2000.0752133.X  0.271
2006 Croissandeau G, Wahnon F, Yashpal K, Seidah NG, Coderre TJ, Chrétien M, Mbikay M. Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2. Neuroscience Letters. 406: 71-5. PMID 16905251 DOI: 10.1016/J.Neulet.2006.07.031  0.27
1997 Marcinkiewicz M, Nagao T, Day R, Seidah NG, Chrétien M, Avoli M. Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression. Neuroscience. 76: 425-39. PMID 9015327 DOI: 10.1016/S0306-4522(96)00318-1  0.27
1983 Seidah NG, Pélaprat D, Rochemont J, Lambelin P, Dennis M, Chan JS, Hamelin J, Lazure C, Chrétien M. Enzymatic maturation of pro-opiomelanocortin by anterior pituitary granules. Methodological approach leading to definite characterization of cleavage sites by means of high-performance liquid chromatography and microsequencing. Journal of Chromatography. 266: 213-24. PMID 6630350 DOI: 10.1016/S0021-9673(01)90895-7  0.27
2010 Khatib AM, Lahlil R, Scamuffa N, Akimenko MA, Ernest S, Lomri A, Lalou C, Seidah NG, Villoutreix BO, Calvo F, Siegfried G. Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration. Plos One. 5: e11438. PMID 20625388 DOI: 10.1371/Journal.Pone.0011438  0.27
1987 Seidah NG, Manjunath P, Rochemont J, Sairam MR, Chrétien M. Complete amino acid sequence of BSP-A3 from bovine seminal plasma. Homology to PDC-109 and to the collagen-binding domain of fibronectin Biochemical Journal. 243: 195-203. PMID 3606570 DOI: 10.1042/Bj2430195  0.269
1984 Seidah NG, Hsi KL, Antakly T, Benjannet S, Chrétien M. Isolation, sequence and cytochemical localization of a conserved novel pituitary-hypothalamic protein Frontiers of Hormone Research. 12: 22-26. DOI: 10.1159/000409149  0.269
1992 Seidah N, Day R, Mbikay M, Chrétien M. Paired basic amino acid convertases of pro-hormones and pro-proteins Neurochemistry International. 21: S1. DOI: 10.1016/0197-0186(92)90002-9  0.269
1996 Santavicca M, Noel A, Angliker H, Stoll I, Segain J, Anglard P, Chretien M, Seidah N, Basset P. Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases Biochemical Journal. 315: 953-958. PMID 8645182 DOI: 10.1042/Bj3150953  0.269
1987 Iguchi H, Natori S, Nawata H, Kato K, Ibayashi H, Chan JS, Seidah NG, Chrétien M. Presence of the novel pituitary protein "7B2" in bovine chromaffin granules: possible co-release of 7B2 and catecholamine as induced by nicotine. Journal of Neurochemistry. 49: 1810-4. PMID 3681297 DOI: 10.1111/J.1471-4159.1987.Tb02440.X  0.268
2019 Ibrahim NS, Lazaris A, Rada M, Petrillo SK, Huck L, Hussain S, Ouladan S, Gao ZH, Gregorieff A, Essalmani R, Seidah NG, Metrakos P. Angiopoietin1 Deficiency in Hepatocytes Affects the Growth of Colorectal Cancer Liver Metastases (CRCLM). Cancers. 12. PMID 31877668 DOI: 10.3390/Cancers12010035  0.268
2007 Pasquato A, Dettin M, Basak A, Gambaretto R, Tonin L, Seidah NG, Di Bello C. Heparin enhances the furin cleavage of HIV-1 gp160 peptides Febs Letters. 581: 5807-5813. PMID 18037384 DOI: 10.1016/J.Febslet.2007.11.050  0.268
1979 Seidah NG, Chan JS, Mardini G, Benjannet S, Chrétien M, Boucher R, Genest J. Specific cleavage of beta-LPH and ACTH by tonin: release of an opiate-like peptide beta-LPH (61-78). Biochemical and Biophysical Research Communications. 86: 1002-13. PMID 219857 DOI: 10.1016/0006-291X(79)90217-1  0.268
2005 Stawowy P, Meyborg H, Stibenz D, Stawowy NBP, Roser M, Thanabalasingam U, Veinot JP, Chrétien M, Seidah NG, Fleck E, Graf K. Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis Circulation. 111: 2820-2827. PMID 15911696 DOI: 10.1161/Circulationaha.104.502617  0.268
2012 Blanchet M, Seidah NG, Labonté P. SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication. Antiviral Research. 95: 159-66. PMID 22626636 DOI: 10.1016/J.Antiviral.2012.05.006  0.268
2000 Laaksonen R, Lefebvre C, Lavigne J, Priceputu E, Bernier L, Davignon J, Mowla S, Bergeron E, Munzer J, Zhong M, Chretien M, Marcinkiewicz M, Seidah N. Inhibition of sterol regulatory element-binding protein cleavage by the prodomain of human SKI-1 protease Atherosclerosis. 151: 287. DOI: 10.1016/S0021-9150(00)81302-7  0.267
1985 Cromlish JA, Seidah NG, Chrétien M. Isolation and characterization of four proteases from porcine pituitary neurointermediate lobes: relationship to the maturation enzyme of prohormones. Neuropeptides. 5: 493-6. PMID 3889696 DOI: 10.1016/0143-4179(85)90062-9  0.267
1981 Gianoulakis C, Seidah NG, Routhier R, Chrétien M. Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis. Further characterization. International Journal of Peptide and Protein Research. 16: 97-105. PMID 7461898 DOI: 10.1111/J.1399-3011.1980.Tb02941.X  0.267
2014 Kebede MA, Oler AT, Gregg T, Balloon AJ, Johnson A, Mitok K, Rabaglia M, Schueler K, Stapleton D, Thorstenson C, Wrighton L, Floyd BJ, Richards O, Raines S, Eliceiri K, ... Seidah NG, et al. SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells. The Journal of Clinical Investigation. 124: 4240-56. PMID 25157818 DOI: 10.1172/Jci74072  0.267
1977 Crine P, Benjannet S, Seidah NG, Lis M, Chrétien M. In vitro biosynthesis of beta-endorphin in pituitary glands. Proceedings of the National Academy of Sciences of the United States of America. 74: 1403-6. PMID 266182 DOI: 10.1073/Pnas.74.4.1403  0.266
2001 Bhattacharjya S, Xu P, Xiang H, Chrétien M, Seidah NG, Ni F. pH-induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: implications for zymogen activation. Protein Science : a Publication of the Protein Society. 10: 934-42. PMID 11316873 DOI: 10.1110/Ps.41301  0.265
1993 Mbikay M, Seidah NG, Chretien M. From proopiomelanocortin to cancer. Possible role of convertases in neoplasia. Annals of the New York Academy of Sciences. 680: 13-9. PMID 8390149 DOI: 10.1111/J.1749-6632.1993.Tb19671.X  0.265
2015 Bridge SH, Sheridan DA, Felmlee DJ, Crossey MM, Fenwick FI, Lanyon CV, Dubuc G, Seidah NG, Davignon J, Thomas HC, Taylor-Robinson SD, Toms GL, Neely RD, Bassendine MF. PCSK9, apolipoprotein E and lipoviral particles in chronic hepatitis C genotype 3: evidence for genotype-specific regulation of lipoprotein metabolism. Journal of Hepatology. 62: 763-70. PMID 25463543 DOI: 10.1016/J.Jhep.2014.11.016  0.265
1992 Watson SJ, Cullinan WE, Schafer MK, Day R, Chretien M, Seidah NG. Anatomical studies of neuropeptide precursor processing enzymes. Clinical Neuropharmacology. 15: 315A-316A. PMID 1498853 DOI: 10.1097/00002826-199201001-00163  0.265
2017 Seidah NG, Abifadel M, Prost S, Boileau C, Prat A. The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9. Pharmacological Reviews. 69: 33-52. PMID 27920219 DOI: 10.1124/pr.116.012989  0.264
1978 Scherrer H, Benjannet S, Pezalla PD, Bourassa M, Seidah NG, Lis M, Chrétien M. Beta-endorphin and beta-lipotropin secretion by an ACTH-secreting mouse pituitary tumor. Febs Letters. 90: 353-6. PMID 208865 DOI: 10.1016/0014-5793(78)80403-7  0.263
2015 Achilleos A, Huffman NT, Marcinkiewicyz E, Seidah NG, Chen Q, Dallas SL, Trainor PA, Gorski JP. MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral development†. Human Molecular Genetics. 24: 2884-98. PMID 25652402 DOI: 10.1093/Hmg/Ddv050  0.262
1985 Marcinkiewicz M, Benjannet S, Sikstrom RA, Cantin M, Seidah NG, Chretien M. Immunoreactivity of vasopressin and a novel pituitary protein ‘7B2’ in long-evans and brattleboro rat hypothalamus and hypophysis Neuroscience Letters. 60: 7-12. PMID 3903556 DOI: 10.1016/0304-3940(85)90373-8  0.261
2007 Tremblay LO, Nagy Kovács E, Daniels E, Wong NK, Sutton-Smith M, Morris HR, Dell A, Marcinkiewicz E, Seidah NG, McKerlie C, Herscovics A. Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation. The Journal of Biological Chemistry. 282: 2558-66. PMID 17121831 DOI: 10.1074/Jbc.M608661200  0.261
2008 Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J, Taylor JM, Schneider JE, Arnold SJ, Johnson P, Tymowska-Lalanne Z, ... ... Seidah NG, et al. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes & Development. 22: 1465-77. PMID 18519639 DOI: 10.1101/Gad.479408  0.261
1982 Lu CL, Cantin M, Seidah NG, Chrétien M. Immunohistochemical localization of human pituitary glycopeptide (HPGP)-like immunoreactivity in the hypothalamus and pituitary of normal and homozygous diabetes insipidus (Brattleboro) rats. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 30: 999-1003. PMID 6752266 DOI: 10.1177/30.10.6752266  0.26
1984 Dennis M, Seidah NG, Chrétien M. Regional heterogeneity in the processing of pro-opiomelanocortin in rat brain. Life Sciences. 49-52. PMID 6319903 DOI: 10.1016/0024-3205(83)90441-1  0.26
1992 Basak A, Yuan XW, Seidah NG, Chrétien M, Lazure C. Affinity purification of proteinases by a combination of immobilized peptidyl aldehyde and semicarbazone. Journal of Chromatography. 581: 17-29. PMID 1430004 DOI: 10.1016/0378-4347(92)80443-T  0.26
1981 Chan JS, Seidah NG, Ikeda M, Gutkowska J, Boucher R, Genest J, Chrétien M. Detection from rat pituitary of beta-lipotropin and materials containing opiatelike activity by combined enzymatic radioreceptor assay. Canadian Journal of Physiology and Pharmacology. 59: 811-7. PMID 6271375 DOI: 10.1139/Y81-120  0.259
1998 Gabreëls BA, Swaab DF, de Kleijn DP, Dean A, Seidah NG, Van de Loo JW, Van de Ven WJ, Martens GJ, Van Leeuwen FW. The vasopressin precursor is not processed in the hypothalamus of Wolfram syndrome patients with diabetes insipidus: evidence for the involvement of PC2 and 7B2. The Journal of Clinical Endocrinology and Metabolism. 83: 4026-33. PMID 9814487 DOI: 10.1210/Jcem.83.11.5158  0.259
1982 Boksa P, Seidah NG, Chrétien M, Livett BG. Effects of pro-opiomelanocortin fragments on release of catecholamines from adrenal chromaffin cells Neuroscience Letters. 28: 199-204. PMID 7070709 DOI: 10.1016/0304-3940(82)90152-5  0.258
1985 Suzuki H, Christofides ND, Adrian TE, Chretien M, Seidah NG, Polak JM, Bloom SR. Ontogeny of a novel pituitary protein (7B2) in the human fetal intestine. Regulatory Peptides. 12: 289-296. PMID 4089228 DOI: 10.1016/0167-0115(85)90172-7  0.258
2008 Pasquato A, Seidah NG. The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains. Journal of Molecular Neuroscience : Mn. 35: 339-43. PMID 18306058 DOI: 10.1007/S12031-008-9052-Z  0.258
2008 Scamuffa N, Basak A, Lalou C, Wargnier A, Marcinkiewicz J, Siegfried G, Chrétien M, Calvo F, Seidah NG, Khatib AM. Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7 Gut. 57: 1573-1582. PMID 18664504 DOI: 10.1136/gut.2007.141812  0.257
1987 Suzuki H, Christofides ND, Chretien M, Seidah NG, Polak JM, Bloom SR. Developmental changes in immunoreactive content of novel pituitary protein 7B2 in human pancreas and its identification in pancreatic tumors. Diabetes. 36: 1276-9. PMID 2822517 DOI: 10.2337/Diab.36.11.1276  0.256
2015 Guillemot J, Seidah NG. PACE4 (PCSK6): another proprotein convertase link to iron homeostasis? Haematologica. 100: e377. PMID 26341526 DOI: 10.3324/Haematol.2015.127175  0.256
1993 Seidah NG, Day R, Chrétien M. The family of pro-hormone and pro-protein convertases. Biochemical Society Transactions. 685-91. PMID 8224490 DOI: 10.1042/Bst0210685  0.256
2021 Susan-Resiga D, Girard E, Essalmani R, Roubtsova A, Marcinkiewicz J, Derbali RM, Evagelidis A, Byun JH, Lebeau PF, Austin RC, Seidah NG. Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by Furin. The Journal of Biological Chemistry. 101177. PMID 34508778 DOI: 10.1016/j.jbc.2021.101177  0.256
2016 Guillemot J, Asselin MC, Susan-Resiga D, Essalmani R, Seidah NG. Deferoxamine stimulates LDLR expression and LDL uptake in HepG2 cells. Molecular Nutrition & Food Research. 60: 600-8. PMID 26577249 DOI: 10.1002/Mnfr.201500467  0.256
2015 Declercq J, Brouwers B, Pruniau VP, Stijnen P, Tuand K, Meulemans S, Prat A, Seidah NG, Khatib AM, Creemers JW. Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth. Biomed Research International. 2015: 148651. PMID 26167473 DOI: 10.1155/2015/148651  0.255
2020 Paquette M, Gauthier D, Chamberland A, Prat A, De Lucia Rolfe E, Rasmussen JJ, Kaduka L, Seidah NG, Bernard S, Christensen DL, Baass A. Circulating PCSK9 is associated with liver biomarkers and hepatic steatosis. Clinical Biochemistry. PMID 31972148 DOI: 10.1016/J.Clinbiochem.2020.01.003  0.255
2010 Maret D, Gruzglin E, Sadr MS, Siu V, Shan W, Koch AW, Seidah NG, Del Maestro RF, Colman DR. Surface expression of precursor N-cadherin promotes tumor cell invasion. Neoplasia (New York, N.Y.). 12: 1066-80. PMID 21170270 DOI: 10.1593/Neo.10954  0.255
2020 Coutard B, Valle C, Lamballerie Xd, Canard B, Seidah NG, Decroly E. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Research. 176: 104742. PMID 32057769 DOI: 10.1016/J.Antiviral.2020.104742  0.254
1978 Seidah NG, Gianoulakis C, Crine P, Lis M, Benjannet S, Routhier R, Chrétien M. In vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia. Proceedings of the National Academy of Sciences of the United States of America. 75: 3153-7. PMID 277917 DOI: 10.1073/Pnas.75.7.3153  0.254
1988 Meador-Woodruff JH, Pellerito B, Vaudry H, Jégou S, Seidah NG, Watson SJ, Akil H. Regional processing of the N- and C-terminal domains of proopiomelanocortin in monkey pituitary and brain. Neuropeptides. 11: 111-8. PMID 2968525 DOI: 10.1016/0143-4179(88)90079-0  0.254
1985 Iguchi H, Chan JS, Dennis M, Seidah NG, Chrétien M. Regional distribution of a novel pituitary protein (7B2) in the rat brain. Brain Research. 338: 91-6. PMID 4027592 DOI: 10.1016/0006-8993(85)90251-3  0.253
1994 Day R, Vieau D, Seidah N. Approaches in the study of the posttranslational processing of opioid peptide peptide precursors: Focus on prodynorphin☆ Regulatory Peptides. 54: 77-78. DOI: 10.1016/0167-0115(94)90397-2  0.253
1988 Brar A, Mbikay M, Sirois F, Fournier S, Seidah NG, Chretien M. Localization of the human prostatic secretory protein PSP94 and its mRNA in the epithelial cells of the prostate Journal of Andrology. 9: 253-260. PMID 3182395 DOI: 10.1002/J.1939-4640.1988.Tb01048.X  0.253
2018 Kim K, Shim D, Lee JS, Zaitsev K, Williams JW, Kim KW, Jang MY, Seok Jang H, Yun TJ, Lee SH, Yoon WK, Prat A, Seidah NG, Choi J, Lee SP, et al. Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models. Circulation Research. 123: 1127-1142. PMID 30359200 DOI: 10.1161/Circresaha.118.312804  0.252
2008 Dubuc G, Tremblay M, Pare G, Jacques H, Boulet L, Genest J, Bernier L, Seidah N, Davignon J. STATINS AND EZETIMIBE UPREGULATE PLASMA PCSK9 Atherosclerosis Supplements. 9: 186. DOI: 10.1016/S1567-5688(08)70747-5  0.251
2010 AbiFadel M, Rabès J, Varret M, Samson-Bouma M, Bruckert E, Devillers M, Carreau V, Tosolini L, Marduel M, Marques A, Couvert P, Bonnefont-Rousselot D, Guérin M, Carrié A, Prat A, ... Seidah N, et al. MS91 PCSK9: FROM GENE AND VARIANTS TO PROTEIN AND PLASMA LEVELS Atherosclerosis Supplements. 11: 128. DOI: 10.1016/S1567-5688(10)70592-4  0.251
1985 Marcinkiewicz M, Benjannet S, Seidah NG, Cantin M, Chrétien M. Immunocytochemical localization of a novel pituitary protein (7B2) within the rat brain and hypophysis. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 33: 1219-26. PMID 4067275 DOI: 10.1177/33.12.4067275  0.251
1996 Lehmann M, Rigot V, Seidah NG, Marvaldi J, Lissitzky JC. Lack of integrin alpha-chain endoproteolytic cleavage in furin-deficient human colon adenocarcinoma cells LoVo. The Biochemical Journal. 803-9. PMID 8760366 DOI: 10.1042/Bj3170803  0.25
2013 Aerts L, Hamelin MÈ, Rhéaume C, Lavigne S, Couture C, Kim W, Susan-Resiga D, Prat A, Seidah NG, Vergnolle N, Riteau B, Boivin G. Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model. Plos One. 8: e72529. PMID 24015257 DOI: 10.1371/Journal.Pone.0072529  0.25
1987 Gaspar L, Chan JS, Seidah NG, Chrétien M. Characterization of N-terminal fragment of proopiomelanocortin in cerebrospinal fluid. The Journal of Clinical Endocrinology and Metabolism. 65: 198-202. PMID 3584397 DOI: 10.1210/Jcem-65-1-198  0.249
1992 Copeland NG, Gilbert DJ, Chrétien M, Seidah NG, Jenkins NA. Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes. Genomics. 13: 1356-8. PMID 1354647 DOI: 10.1016/0888-7543(92)90069-5  0.248
1987 SEIDAH NG, CROMLISH JA, THIBAULT G, CHRÉTIEN M. IRCM-Serine Protease # 1 from Pituitary and Heart A Common Prohormone Maturation Enzyme Annals of the New York Academy of Sciences. 493: 403-405. DOI: 10.1111/J.1749-6632.1987.Tb27225.X  0.248
1987 Iguchi H, Natori S, Nawata H, Kato K, Ibayashi H, Chan JS, Seidah NG, Chretien M. Elevation of plasma 7B2 (a novel pituitary protein) in cord blood at obstetrical delivery and the possible correlation with GH. Life Sciences. 41: 1921-7. PMID 3116360 DOI: 10.1016/0024-3205(87)90744-2  0.247
1983 Lu CL, Chan JS, De Léan A, Chen A, Seidah NG, Chrétien M. Metabolic clearance rate and half-time disappearance rate of human N-terminal and adrenocorticotropin of pro-opiomelanocortin in the rat: a comparative study. Life Sciences. 33: 2599-608. PMID 6319844 DOI: 10.1016/0024-3205(83)90343-0  0.247
1986 van Leeuwen FW, Caffé R, van der Sluis PJ, Sluiter AA, van der Woude TP, Seidah NG, Chrétien M. Propressophysin is present in neurones at multiple sites in Wistar and homozygous Brattleboro rat brain. Brain Research. 379: 171-5. PMID 3742211 DOI: 10.1016/0006-8993(86)90272-6  0.247
2005 Costa-Mattioli M, Gobert D, Harding H, Herdy B, Azzi M, Bruno M, Bidinosti M, Ben Mamou C, Marcinkiewicz E, Yoshida M, Imataka H, Cuello AC, Seidah N, Sossin W, Lacaille JC, et al. Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature. 436: 1166-73. PMID 16121183 DOI: 10.1038/Nature03897  0.246
1985 SUZUKI H, CHRISTOFIDES ND, CHRETIEN M, SEIDAH NG, POLAK JM, BLOOM SR. A NOVEL PITUITARY PROTEIN (7B2) IN THE RAT UROGENITAL TRACT Biomedical Research. 6: 139-143. DOI: 10.2220/Biomedres.6.139  0.245
2008 Meckler X, Vetrivel KS, Chen Y, Li T, Seidah NG, Vassar R, Wong PC, Fukata M, Thinakaran G. P3-337: S-palmitoylation targets BACE-1 to lipid rafts Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1906  0.245
2019 Garcon D, Ayer A, Moreau F, Seidah N, Prat A, Prieur X, Pichelin M, Cariou B, May CL. Pharmacological Inhibition And Hepatic-Deficiency Of Pcsk9 Reduce Post-Prandial Lipemia In Mice Atherosclerosis. 287. DOI: 10.1016/J.Atherosclerosis.2019.06.008  0.245
1998 Barbero P, Rovère C, De Bie I, Seidah N, Beaudet A, Kitabgi P. PC5-A-mediated processing of pro-neurotensin in early compartments of the regulated secretory pathway of PC5-transfected PC12 cells. The Journal of Biological Chemistry. 273: 25339-46. PMID 9738000 DOI: 10.1074/jbc.273.39.25339  0.244
1995 Gabreëls BA, Swaab DF, Seidah NG, van Duijnhoven HL, Martens GJ, van Leeuwen FW. Differential expression of the neuroendocrine polypeptide 7B2 in hypothalami of Prader-(Labhart)-Willi syndrome patients. Brain Research. 657: 281-93. PMID 7820629 DOI: 10.1016/0006-8993(94)90978-4  0.244
2004 Amiri F, Virdis A, Neves MF, Iglarz M, Seidah NG, Touyz RM, Reudelhuber TL, Schiffrin EL. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation. 110: 2233-40. PMID 15466627 DOI: 10.1161/01.Cir.0000144462.08345.B9  0.244
1982 Lu CL, Cantin M, Seidah NG, Chrétien M. Distribution pattern in the human pituitary and hypothalamus of a new neuropeptide: the C-terminal glycoprotein-fragment of human pro-pressophysin (CPP). Histochemistry and Cell Biology. 75: 319-326. PMID 7141886 DOI: 10.1007/Bf00496735  0.242
1990 Linard CG, Mbikay M, Seidah NG, Chretien M. Primary structure of mouse chromogranin B deduced from cDNA sequence. Nucleic Acids Research. 18: 1298. PMID 2320426 DOI: 10.1093/Nar/18.5.1298  0.241
1995 Mbikay M, Seidah NG, Chrétien M, Simpson EM. Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. Genomics. 26: 123-9. PMID 7782070 DOI: 10.1016/0888-7543(95)80090-9  0.241
2004 Stawowy P, Margeta C, Kallisch H, Seidah NG, Chrétien M, Fleck E, Graf K. Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-β1 involves furin-convertase Cardiovascular Research. 63: 87-97. PMID 15194465 DOI: 10.1016/J.Cardiores.2004.03.010  0.241
2018 Mikaeeli S, Ouadda ABD, Hamelin J, Resiga DS, Seidah NG. Functional Analysis of Novel PCSK9 Mutants from Sapiens (R96L, R105W and P174S) and Denisovan (H449L) Atherosclerosis Supplements. 32: 60. DOI: 10.1016/J.Atherosclerosissup.2018.04.180  0.24
2015 Gorski JP, Huffman NT, Vallejo J, Brotto L, Chittur SV, Breggia A, Stern A, Huang J, Mo C, Seidah NG, Bonewald L, Brotto M. Deletion of Mbtps1 (PCSK8, S1P, SKI-1) in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age. The Journal of Biological Chemistry. PMID 26719336 DOI: 10.1074/Jbc.M115.686626  0.24
1986 Chan JS, Nie ZR, Seidah NG, Chrétien M. Inhibition of binding of ovine placental lactogen to growth hormone and prolactin receptors by monoclonal antibodies. Endocrinology. 119: 2623-8. PMID 2430784 DOI: 10.1210/Endo-119-6-2623  0.24
2008 Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Li T, Wong PC, Seidah NG, Vassar R, Thinakaran G. O2-03-01: Exploring β-secretase activity in lipid raft microdomains Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.322  0.24
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