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Christine Bear - Publications

Affiliations: 
Biochemistry University of Toronto, Toronto, ON, Canada 
Area:
Cell Biology, Physiology Biology, Pharmacology, Biochemistry
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123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chin S, Ramjeesingh M, Hung M, Ereño-Oreba J, Cui H, Laselva O, Julien JP, Bear CE. Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Cells. 8. PMID 31370288 DOI: 10.3390/cells8080804  0.52
2018 Eckford PDW, McCormack J, Munsie L, He G, Stanojevic S, Pereira SL, Ho K, Avolio J, Bartlett C, Yang JY, Wong AP, Wellhauser L, Huan LJ, Jiang JX, Ouyang H, ... ... Bear CE, et al. The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 29685812 DOI: 10.1016/j.jcf.2018.03.013  0.36
2017 Molinski SV, Ahmadi S, Ip W, Ouyang H, Villella A, Miller JP, Lee PS, Kulleperuma K, Du K, Di Paola M, Eckford PD, Laselva O, Huan LJ, Wellhauser L, Li E, ... ... Bear CE, et al. Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue. Embo Molecular Medicine. PMID 28667089 DOI: 10.15252/emmm.201607137  0.36
2017 Ahmadi S, Bozoky Z, Di Paola M, Xia S, Li C, Wong AP, Wellhauser L, Molinski SV, Ip W, Ouyang H, Avolio J, Forman-Kay JD, Ratjen F, Hirota JA, Rommens J, ... ... Bear CE, et al. Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia. Npj Genomic Medicine. 2: 12. PMID 28649446 DOI: 10.1038/s41525-017-0015-6  0.36
2016 Chin S, Hung M, Bear CE. Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants. Cellular and Molecular Life Sciences : Cmls. PMID 27722768 DOI: 10.1007/s00018-016-2388-6  0.52
2016 Laselva O, Molinski S, Casavola V, Bear CE. The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain. Biochemical Pharmacology. PMID 27614011 DOI: 10.1016/j.bcp.2016.09.005  0.52
2015 Ehrhardt A, Chung WJ, Pyle LC, Wang W, Nowotarski K, Mulvihill CM, Ramjeesingh M, Hong J, Velu SE, Lewis HA, Atwell S, Aller S, Bear CE, Lukacs GL, Kirk KL, et al. Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop. The Journal of Biological Chemistry. PMID 26627831 DOI: 10.1074/jbc.M115.704809  0.52
2015 Verkman AS, Edelman A, Amaral M, Mall MA, Beekman JM, Meiners T, Galietta LJ, Bear CE. Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 14: 700-5. PMID 26474804 DOI: 10.1016/j.jcf.2015.10.001  0.52
2015 Molinski SV, Ahmadi S, Hung M, Bear CE. Facilitating Structure-Function Studies of CFTR Modulator Sites with Efficiencies in Mutagenesis and Functional Screening. Journal of Biomolecular Screening. 20: 1204-17. PMID 26385858 DOI: 10.1177/1087057115605834  0.52
2015 Ogawa M, Ogawa S, Bear CE, Ahmadi S, Chin S, Li B, Grompe M, Keller G, Kamath BM, Ghanekar A. Directed differentiation of cholangiocytes from human pluripotent stem cells. Nature Biotechnology. 33: 853-61. PMID 26167630 DOI: 10.1038/nbt.3294  0.52
2015 Malik FA, Meissner A, Semenkov I, Molinski S, Pasyk S, Ahmadi S, Bui HH, Bear CE, Lidington D, Bolz SS. Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity. Plos One. 10: e0130313. PMID 26079370 DOI: 10.1371/journal.pone.0130313  0.52
2015 Eckford PD, Li C, Bear CE. Functional reconstitution and channel activity measurements of purified wildtype and mutant CFTR protein. Journal of Visualized Experiments : Jove. PMID 25867140 DOI: 10.3791/52427  0.52
2015 Shojaie S, Ermini L, Ackerley C, Wang J, Chin S, Yeganeh B, Bilodeau M, Sambi M, Rogers I, Rossant J, Bear CE, Post M. Acellular lung scaffolds direct differentiation of endoderm to functional airway epithelial cells: requirement of matrix-bound HS proteoglycans. Stem Cell Reports. 4: 419-30. PMID 25660407 DOI: 10.1016/j.stemcr.2015.01.004  0.52
2015 Wong AP, Chin S, Xia S, Garner J, Bear CE, Rossant J. Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells. Nature Protocols. 10: 363-81. PMID 25654755 DOI: 10.1038/nprot.2015.021  0.52
2015 Pasyk S, Molinski S, Ahmadi S, Ramjeesingh M, Huan LJ, Chin S, Du K, Yeger H, Taylor P, Moran MF, Bear CE. The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation. Proteomics. 15: 447-61. PMID 25330774 DOI: 10.1002/pmic.201400218  0.52
2015 Broadbent SD, Ramjeesingh M, Bear CE, Argent BE, Linsdell P, Gray MA. The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor. PflüGers Archiv : European Journal of Physiology. 467: 1783-94. PMID 25277268 DOI: 10.1007/s00424-014-1618-8  0.52
2014 Jaecklin T, Duerr J, Huang H, Rafii M, Bear CE, Ratjen F, Pencharz P, Kavanagh BP, Mall MA, Grasemann H. Lung arginase expression and activity is increased in cystic fibrosis mouse models. Journal of Applied Physiology (Bethesda, Md. : 1985). 117: 284-8. PMID 24925982 DOI: 10.1152/japplphysiol.00167.2014  0.52
2014 Eckford PD, Ramjeesingh M, Molinski S, Pasyk S, Dekkers JF, Li C, Ahmadi S, Ip W, Chung TE, Du K, Yeger H, Beekman J, Gonska T, Bear CE. VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface. Chemistry & Biology. 21: 666-78. PMID 24726831 DOI: 10.1016/j.chembiol.2014.02.021  0.52
2014 Molinski SV, Gonska T, Huan LJ, Baskin B, Janahi IA, Ray PN, Bear CE. Genetic, cell biological, and clinical interrogation of the CFTR mutation c.3700 A>G (p.Ile1234Val) informs strategies for future medical intervention. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 16: 625-32. PMID 24556927 DOI: 10.1038/gim.2014.4  0.52
2013 Islam ST, Eckford PD, Jones ML, Nugent T, Bear CE, Vogel C, Lam JS. Proton-dependent gating and proton uptake by Wzx support O-antigen-subunit antiport across the bacterial inner membrane. Mbio. 4: e00678-13. PMID 24023388 DOI: 10.1128/mBio.00678-13  0.52
2013 D'Antonio C, Molinski S, Ahmadi S, Huan LJ, Wellhauser L, Bear CE. Conformational defects underlie proteasomal degradation of Dent's disease-causing mutants of ClC-5. The Biochemical Journal. 452: 391-400. PMID 23566014 DOI: 10.1042/BJ20121848  0.52
2013 Bear CE. 50 years ago in the Journal of Pediatrics: the effect of N-acetylcysteine on the viscosity of tracheobronchial secretions in cystic fibrosis of the pancreas. The Journal of Pediatrics. 162: 85. PMID 23260312 DOI: 10.1016/j.jpeds.2012.08.006  0.52
2012 Molinski S, Eckford PD, Pasyk S, Ahmadi S, Chin S, Bear CE. Functional Rescue of F508del-CFTR Using Small Molecule Correctors. Frontiers in Pharmacology. 3: 160. PMID 23055971 DOI: 10.3389/fphar.2012.00160  0.52
2012 Eckford PD, Li C, Ramjeesingh M, Bear CE. Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner. The Journal of Biological Chemistry. 287: 36639-49. PMID 22942289 DOI: 10.1074/jbc.M112.393637  0.52
2012 Wong AP, Bear CE, Chin S, Pasceri P, Thompson TO, Huan LJ, Ratjen F, Ellis J, Rossant J. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nature Biotechnology. 30: 876-82. PMID 22922672 DOI: 10.1038/nbt.2328  0.52
2012 Pasyk S, Molinski S, Yu W, Eckford PD, Bear CE. Identification and validation of hits from high throughput screens for CFTR modulators. Current Pharmaceutical Design. 18: 628-41. PMID 22229556 DOI: 10.2174/138161212799315957  0.52
2011 Alkhouri B, Denning RA, Kim Chiaw P, Eckford PD, Yu W, Li C, Bogojeski JJ, Bear CE, Viirre RD. Synthesis and properties of molecular probes for the rescue site on mutant cystic fibrosis transmembrane conductance regulator. Journal of Medicinal Chemistry. 54: 8693-701. PMID 22074181 DOI: 10.1021/jm201335c  0.52
2011 Kim Chiaw P, Eckford PD, Bear CE. Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy. Essays in Biochemistry. 50: 233-48. PMID 21967060 DOI: 10.1042/bse0500233  0.52
2011 Whitney JC, Hay ID, Li C, Eckford PD, Robinson H, Amaya MF, Wood LF, Ohman DE, Bear CE, Rehm BH, Howell PL. Structural basis for alginate secretion across the bacterial outer membrane. Proceedings of the National Academy of Sciences of the United States of America. 108: 13083-8. PMID 21778407 DOI: 10.1073/pnas.1104984108  0.52
2011 Eckford PD, Bear CE. Targeting the regulation of CFTR channels. The Biochemical Journal. 435: e1-4. PMID 21726198 DOI: 10.1042/BJ20110461  0.52
2011 Yu W, Kim Chiaw P, Bear CE. Probing conformational rescue induced by a chemical corrector of F508del-cystic fibrosis transmembrane conductance regulator (CFTR) mutant. The Journal of Biological Chemistry. 286: 24714-25. PMID 21602569 DOI: 10.1074/jbc.M111.239699  0.52
2011 Wellhauser L, Luna-Chavez C, D'Antonio C, Tainer J, Bear CE. ATP induces conformational changes in the carboxyl-terminal region of ClC-5. The Journal of Biological Chemistry. 286: 6733-41. PMID 21173145 DOI: 10.1074/jbc.M110.175877  0.52
2010 Lamhonwah AM, Bear CE, Huan LJ, Kim Chiaw P, Ackerley CA, Tein I. Cystic fibrosis transmembrane conductance regulator in human muscle: Dysfunction causes abnormal metabolic recovery in exercise. Annals of Neurology. 67: 802-8. PMID 20517942 DOI: 10.1002/ana.21982  0.52
2010 Kim Chiaw P, Wellhauser L, Huan LJ, Ramjeesingh M, Bear CE. A chemical corrector modifies the channel function of F508del-CFTR. Molecular Pharmacology. 78: 411-8. PMID 20501743 DOI: 10.1124/mol.110.065862  0.52
2010 Cortez MA, Li C, Whitehead SN, Dhani SU, D'Antonio C, Huan LJ, Bennett SA, Snead OC, Bear CE. Disruption of ClC-2 expression is associated with progressive neurodegeneration in aging mice. Neuroscience. 167: 154-62. PMID 20116415 DOI: 10.1016/j.neuroscience.2010.01.042  0.52
2010 Wellhauser L, D'Antonio C, Bear CE. ClC transporters: discoveries and challenges in defining the mechanisms underlying function and regulation of ClC-5. PflüGers Archiv : European Journal of Physiology. 460: 543-57. PMID 20049483 DOI: 10.1007/s00424-009-0769-5  0.52
2009 Kim Chiaw P, Huan LJ, Gagnon S, Ly D, Sweezey N, Rotin D, Deber CM, Bear CE. Functional rescue of DeltaF508-CFTR by peptides designed to mimic sorting motifs. Chemistry & Biology. 16: 520-30. PMID 19477416 DOI: 10.1016/j.chembiol.2009.04.005  0.52
2009 Mohammad-Panah R, Wellhauser L, Steinberg BE, Wang Y, Huan LJ, Liu XD, Bear CE. An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice. Journal of Cell Science. 122: 1229-37. PMID 19339555 DOI: 10.1242/jcs.037317  0.52
2009 Wellhauser L, Kim Chiaw P, Pasyk S, Li C, Ramjeesingh M, Bear CE. A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability. Molecular Pharmacology. 75: 1430-8. PMID 19339490 DOI: 10.1124/mol.109.055608  0.52
2009 Cheung JC, Kim Chiaw P, Deber CM, Bear CE. A novel method for monitoring the cytosolic delivery of peptide cargo. Journal of Controlled Release : Official Journal of the Controlled Release Society. 137: 2-7. PMID 19285529 DOI: 10.1016/j.jconrel.2009.02.022  0.52
2009 Pasyk S, Li C, Ramjeesingh M, Bear CE. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. The Biochemical Journal. 418: 185-90. PMID 18945216 DOI: 10.1042/BJ20081424  0.52
2008 Cheung JC, Kim Chiaw P, Pasyk S, Bear CE. Molecular basis for the ATPase activity of CFTR. Archives of Biochemistry and Biophysics. 476: 95-100. PMID 18417076 DOI: 10.1016/j.abb.2008.03.033  0.52
2008 Mumbengegwi DR, Li Q, Li C, Bear CE, Engelhardt JF. Evidence for a superoxide permeability pathway in endosomal membranes. Molecular and Cellular Biology. 28: 3700-12. PMID 18378695 DOI: 10.1128/MCB.02038-07  0.52
2008 Payandeh J, Li C, Ramjeesingh M, Poduch E, Bear CE, Pai EF. Probing structure-function relationships and gating mechanisms in the CorA Mg2+ transport system. The Journal of Biological Chemistry. 283: 11721-33. PMID 18276588 DOI: 10.1074/jbc.M707889200  0.52
2008 Ramjeesingh M, Ugwu F, Stratford FL, Huan LJ, Li C, Bear CE. The intact CFTR protein mediates ATPase rather than adenylate kinase activity. The Biochemical Journal. 412: 315-21. PMID 18241200 DOI: 10.1042/BJ20071719  0.52
2008 Dhani SU, Kim Chiaw P, Huan LJ, Bear CE. ATP depletion inhibits the endocytosis of ClC-2. Journal of Cellular Physiology. 214: 273-80. PMID 17620322 DOI: 10.1002/jcp.21192  0.52
2007 Stratford FL, Ramjeesingh M, Cheung JC, Huan LJ, Bear CE. The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer. The Biochemical Journal. 401: 581-6. PMID 16989640 DOI: 10.1042/BJ20060968  0.52
2006 Wellhauser L, Kuo HH, Stratford FL, Ramjeesingh M, Huan LJ, Luong W, Li C, Deber CM, Bear CE. Nucleotides bind to the C-terminus of ClC-5. The Biochemical Journal. 398: 289-94. PMID 16686597 DOI: 10.1042/BJ20060142  0.52
2006 Ramjeesingh M, Li C, She YM, Bear CE. Evaluation of the membrane-spanning domain of ClC-2. The Biochemical Journal. 396: 449-60. PMID 16526942 DOI: 10.1042/BJ20060043  0.52
2006 Dhani SU, Bear CE. Role of intramolecular and intermolecular interactions in ClC channel and transporter function. PflüGers Archiv : European Journal of Physiology. 451: 708-15. PMID 16167151 DOI: 10.1007/s00424-005-1513-4  0.52
2004 Kogan I, Ramjeesingh M, Bear CE. ATPase assay of purified, reconstituted CFTR protein. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 3: 133-4. PMID 15463945 DOI: 10.1016/j.jcf.2004.05.028  0.52
2004 Norez C, Heda GD, Jensen T, Kogan I, Hughes LK, Auzanneau C, Dérand R, Bulteau-Pignoux L, Li C, Ramjeesingh M, Li H, Sheppard DN, Bear CE, Riordan JR, Becq F. Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 3: 119-21. PMID 15463942 DOI: 10.1016/j.jcf.2004.05.025  0.52
2004 Sheppard DN, Gray MA, Gong X, Sohma Y, Kogan I, Benos DJ, Scott-Ward TS, Chen JH, Li H, Cai Z, Gupta J, Li C, Ramjeesingh M, Berdiev BK, Ismailov II, ... Bear CE, et al. The patch-clamp and planar lipid bilayer techniques: powerful and versatile tools to investigate the CFTR Cl- channel. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 3: 101-8. PMID 15463939 DOI: 10.1016/j.jcf.2004.05.046  0.52
2004 Benos DJ, Berdiev BK, Ismailov II, Ostedgaard LS, Kogan I, Li C, Ramjeesingh M, Bear CE. Methods to study CFTR protein in vitro. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 3: 79-83. PMID 15463933 DOI: 10.1016/j.jcf.2004.05.018  0.52
2004 Kidd JF, Ramjeesingh M, Stratford F, Huan LJ, Bear CE. A heteromeric complex of the two nucleotide binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) mediates ATPase activity. The Journal of Biological Chemistry. 279: 41664-9. PMID 15284228 DOI: 10.1074/jbc.M407666200  0.52
2004 Kidd JF, Kogan I, Bear CE. Molecular basis for the chloride channel activity of cystic fibrosis transmembrane conductance regulator and the consequences of disease-causing mutations. Current Topics in Developmental Biology. 60: 215-49. PMID 15094300 DOI: 10.1016/S0070-2153(04)60007-X  0.52
2004 Grimard V, Li C, Ramjeesingh M, Bear CE, Goormaghtigh E, Ruysschaert JM. Phosphorylation-induced conformational changes of cystic fibrosis transmembrane conductance regulator monitored by attenuated total reflection-Fourier transform IR spectroscopy and fluorescence spectroscopy. The Journal of Biological Chemistry. 279: 5528-36. PMID 14660584 DOI: 10.1074/jbc.M311014200  0.52
2003 Ramjeesingh M, Ugwu F, Li C, Dhani S, Huan LJ, Wang Y, Bear CE. Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore. The Biochemical Journal. 375: 633-41. PMID 12892562 DOI: 10.1042/BJ20030774  0.52
2003 Ramjeesingh M, Kidd JF, Huan LJ, Wang Y, Bear CE. Dimeric cystic fibrosis transmembrane conductance regulator exists in the plasma membrane. The Biochemical Journal. 374: 793-7. PMID 12820897 DOI: 10.1042/BJ20030683  0.52
2003 Mohammad-Panah R, Harrison R, Dhani S, Ackerley C, Huan LJ, Wang Y, Bear CE. The chloride channel ClC-4 contributes to endosomal acidification and trafficking. The Journal of Biological Chemistry. 278: 29267-77. PMID 12746443 DOI: 10.1074/jbc.M304357200  0.52
2003 Kogan I, Ramjeesingh M, Li C, Kidd JF, Wang Y, Leslie EM, Cole SP, Bear CE. CFTR directly mediates nucleotide-regulated glutathione flux. The Embo Journal. 22: 1981-9. PMID 12727866 DOI: 10.1093/emboj/cdg194  0.52
2003 Dhani SU, Mohammad-Panah R, Ahmed N, Ackerley C, Ramjeesingh M, Bear CE. Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex. The Journal of Biological Chemistry. 278: 16262-70. PMID 12601004 DOI: 10.1074/jbc.M209828200  0.52
2002 Kidd JF, Bear CE. Epithelial cell chloride channel activity correlates with improved airway function in cystic fibrosis patients with the major mutant: Delta F508. Pediatric Research. 52: 625-7. PMID 12409505 DOI: 10.1203/00006450-200211000-00004  0.52
2002 Pan J, Bear C, Farragher S, Cutz E, Yeger H. Cystic fibrosis transmembrane conductance regulator modulates neurosecretory function in pulmonary neuroendocrine cell-related tumor cell line models. American Journal of Respiratory Cell and Molecular Biology. 27: 553-60. PMID 12397014 DOI: 10.1165/rcmb.4843  0.52
2002 Kogan I, Ramjeesingh M, Li C, Bear CE. Studies of the molecular basis for cystic fibrosis using purified reconstituted CFTR protein. Methods in Molecular Medicine. 70: 143-57. PMID 11917519 DOI: 10.1385/1-59259-187-6:143  0.52
2002 Mohammad-Panah R, Ackerley C, Rommens J, Choudhury M, Wang Y, Bear CE. The chloride channel ClC-4 co-localizes with cystic fibrosis transmembrane conductance regulator and may mediate chloride flux across the apical membrane of intestinal epithelia. The Journal of Biological Chemistry. 277: 566-74. PMID 11675385 DOI: 10.1074/jbc.M106968200  0.52
2001 Gyömörey K, Garami E, Galley K, Rommens JM, Bear CE. Non-CFTR chloride channels likely contribute to secretion in the murine small intestine. PflüGers Archiv : European Journal of Physiology. 443: S103-6. PMID 11845313 DOI: 10.1007/s004240100654  0.52
2001 Ramjeesingh M, Li C, Kogan I, Wang Y, Huan LJ, Bear CE. A monomer is the minimum functional unit required for channel and ATPase activity of the cystic fibrosis transmembrane conductance regulator. Biochemistry. 40: 10700-6. PMID 11524016 DOI: 10.1021/bi0108195  0.52
2001 Yeger H, Pan J, Fu XW, Bear C, Cutz E. Expression of CFTR and Cl- conductances in cells of pulmonary neuroepithelial bodies American Journal of Physiology - Lung Cellular and Molecular Physiology. 281. PMID 11504700 DOI: 10.1152/AJPLUNG.2001.281.3.L713  0.52
2001 Kogan I, Ramjeesingh M, Huan LJ, Wang Y, Bear CE. Perturbation of the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibits its atpase activity. The Journal of Biological Chemistry. 276: 11575-81. PMID 11124965 DOI: 10.1074/jbc.M010403200  0.52
2001 Mohammad-Panah R, Gyomorey K, Rommens J, Choudhury M, Li C, Wang Y, Bear CE. ClC-2 contributes to native chloride secretion by a human intestinal cell line, Caco-2. The Journal of Biological Chemistry. 276: 8306-13. PMID 11096079 DOI: 10.1074/jbc.M006764200  0.52
2001 Bear C, Shori D. Editorial to conference proceedings Pflugers Archiv European Journal of Physiology. 443. DOI: 10.1007/s004240100634  0.52
2000 Ahmed N, Ramjeesingh M, Wong S, Varga A, Garami E, Bear CE. Chloride channel activity of CIC-2 is modified by the actin cytoskeleton Biochemical Journal. 352: 789-794. PMID 11104687 DOI: 10.1042/0264-6021:3520789  0.52
2000 Gyömörey K, Rozmahel R, Bear CE. Amelioration of intestinal disease severity in cystic fibrosis mice is associated with improved chloride secretory capacity. Pediatric Research. 48: 731-4. PMID 11102538 DOI: 10.1203/00006450-200012000-00005  0.52
2000 Gyömörey K, Yeger H, Ackerley C, Garami E, Bear CE. Expression of the chloride channel ClC-2 in the murine small intestine epithelium. American Journal of Physiology. Cell Physiology. 279: C1787-94. PMID 11078693  0.52
2000 Ramjeesingh M, Li C, Huan LJ, Garami E, Wang Y, Bear CE. Quaternary structure of the chloride channel ClC-2 Biochemistry. 39: 13838-13847. PMID 11076524 DOI: 10.1021/bi001282i  0.52
2000 Seradge H, Bear C, Bithell D. Preventing carpal tunnel syndrome and cumulative trauma disorder: effect of carpal tunnel decompression excercises: an Oklahoma experience The Journal of the Oklahoma State Medical Association. 93: 150-153. PMID 10793505  0.52
1999 Ramjeesingh M, Huan LJ, Garami E, Bear CE. Novel method for evaluation of the oligomeric structure of membrane proteins Biochemical Journal. 342: 119-123. PMID 10432308 DOI: 10.1042/0264-6021:3420119  0.52
1999 Ramjeesingh M, Li C, Garami E, Huan LJ, Galley K, Wang Y, Bear CE. Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator) Biochemistry. 38: 1463-1468. PMID 9931011 DOI: 10.1021/bi982243y  0.52
1999 Xiong H, Li C, Garami E, Wang Y, Ramjeesingh M, Galley K, Bear CE. ClC-2 activation modulates regulatory volume decrease Journal of Membrane Biology. 167: 215-221. PMID 9929373 DOI: 10.1007/s002329900485  0.52
1999 Pasyk EA, Morin XK, Zeman P, Garami E, Galley K, Huan LJ, Wang Y, Bear CE. A conserved region of the R domain of cystic fibrosis transmembrane conductance regulator is important in processing and function Journal of Biological Chemistry. 273: 31759-31764. PMID 9822639 DOI: 10.1074/jbc.273.48.31759  0.52
1998 Ramjeesingh M, Garami E, Galley K, Li C, Wang Y, Bear CE. Purification and reconstitution of epithelial chloride channel cystic fibrosis transmembrane conductance regulator Methods in Enzymology. 294: 227-246. PMID 9916230 DOI: 10.1016/S0076-6879(99)94014-4  0.52
1998 Li C, Breton S, Morrison R, Cannon CL, Emma F, Sanchez-Olea R, Bear C, Strange K. Recombinant pICln forms highly cation-selective channels when reconstituted into artificial and biological membranes. The Journal of General Physiology. 112: 727-36. PMID 9834142 DOI: 10.1085/jgp.112.6.727  0.52
1998 Ramjeesingh M, Huan LJ, Wilschanski M, Durie P, Li C, Gyomorey K, Wang Y, Kent G, Tanswell KA, Cutz E, Ackerley C, Bear CE. Assessment of the efficacy of in vivo CFTR protein replacement therapy in CF mice. Human Gene Therapy. 9: 521-8. PMID 9525313 DOI: 10.1089/hum.1998.9.4-521  0.52
1998 Rozmahel R, Nguyen V, Corey M, Haston CK, Kent G, Bear C, Durie P, Tsui LC. Defining the modifiers of CF pathophysiology Pediatric Pulmonology. 26: 126.  0.52
1997 Bear CE, Li C, Galley K, Wang Y, Garami E, Ramjeesingh M. Coupling of ATP hydrolysis with channel gating by purified, reconstituted CFTR Journal of Bioenergetics and Biomembranes. 29: 465-473. PMID 9511931 DOI: 10.1023/A:1022435007193  0.52
1997 Kent G, Iles R, Bear CE, Huan LJ, Griesenbach U, McKerlie C, Frndova H, Ackerley C, Gosselin D, Radzioch D, O'Brodovich H, Tsui LC, Buchwald M, Tanswell AK. Lung disease in mice with cystic fibrosis. The Journal of Clinical Investigation. 100: 3060-9. PMID 9399953 DOI: 10.1172/JCI119861  0.52
1997 Ramjeesingh M, Li C, Garami E, Huan LJ, Hewryk M, Wang Y, Galley K, Bear CE. A novel procedure for the efficient purification of the cystic fibrosis transmembrane conductance regulator (CFTR) Biochemical Journal. 327: 17-21. PMID 9355728  0.52
1997 Rozmahel R, Gyömörey K, Plyte S, Nguyen V, Wilschanski M, Durie P, Bear CE, Tsui LC. Incomplete rescue of cystic fibrosis transmembrane conductance regulator deficient mice by the human CFTR cDNA. Human Molecular Genetics. 6: 1153-62. PMID 9215687 DOI: 10.1093/hmg/6.7.1153  0.52
1997 Xiong H, Garami E, Wang Y, Galley K, Ramjeesingh M, Bear C. Functional expression of CIC-2 chloride channel in Sf9 insect cells Faseb Journal. 11.  0.52
1996 Li C, Ramjeesingh M, Wang W, Garami E, Hewryk M, Lee D, Rommens JM, Galley K, Bear CE. ATPase activity of the cystic fibrosis transmembrane conductance regulator Journal of Biological Chemistry. 271: 28463-28468. PMID 8910473 DOI: 10.1074/jbc.271.45.28463  0.52
1996 Li C, Ramjeesingh M, Bear CE. Purified cystic fibrosis transmembrane conductance regulator (CFTR) does not function as an ATP channel Journal of Biological Chemistry. 271: 11623-11626. PMID 8662751 DOI: 10.1074/jbc.271.20.11623  0.52
1996 Wilschanski MA, Rozmahel R, Beharry S, Kent G, Li C, Tsui LC, Durie P, Bear CE. In vivo measurements of ion transport in long-living CF mice Biochemical and Biophysical Research Communications. 219: 753-759. PMID 8645253 DOI: 10.1006/bbrc.1996.0306  0.52
1996 Rozmahel R, Wilschanski M, Matin A, Plyte S, Oliver M, Auerbach W, Moore A, Forstner J, Durie P, Nadeau J, Bear C, Tsui LC. Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor Nature Genetics. 12: 280-287. PMID 8589719 DOI: 10.1038/ng0396-280  0.52
1995 O'Riordan CR, Erickson A, Bear C, Li C, Manavalan P, Wang KX, Marshall J, Scheule RK, McPherson JM, Cheng SH. Purification and characterization of recombinant cystic fibrosis transmembrane conductance regulator from Chinese hamster ovary and insect cells. The Journal of Biological Chemistry. 270: 17033-43. PMID 7542655 DOI: 10.1074/jbc.270.28.17033  0.52
1995 Krolczyk AJ, Bear CE, Lai PFH, Schimmer BP. Effects of mutations in cAMP‐dependent protein kinase on chloride efflux in Caco‐2 human colonic carcinoma cells Journal of Cellular Physiology. 162: 64-73. PMID 7529238 DOI: 10.1002/jcp.1041620109  0.52
1995 Morin XK, Bond TD, Loo TW, Clarke DM, Bear CE. Failure of P‐glycoprotein (MDR1) expressed in Xenopus oocytes to produce swelling‐activated chloride channel activity The Journal of Physiology. 486: 707-714. PMID 7473231 DOI: 10.1113/jphysiol.1995.sp020846  0.52
1994 Bear CE. Drugs transported by P-glycoprotein inhibit a 40pS outwardly rectifying chloride channel Biochemical and Biophysical Research Communications. 200: 513-521. PMID 7909435 DOI: 10.1006/bbrc.1994.1478  0.52
1993 Lukacs GL, Chang XB, Bear C, Kartner N, Mohamed A, Riordan JR, Grinstein S. The ΔF508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane: Determination of functional half-lives on transfected cells Journal of Biological Chemistry. 268: 21592-21598. PMID 7691813  0.52
1993 O'Brodovich H, Wang X, Li C, Rafii B, Correa J, Bear C. Novobiocin forms cation-permeable ion channels in rat fetal distal lung epithelium. The American Journal of Physiology. 264: C1532-7. PMID 7687410  0.52
1993 Bear C, Ling V. Multidrug resistance and cystic fibrosis genes: complementarity of function? Trends in Genetics : Tig. 9: 67-8. PMID 7683829 DOI: 10.1016/0168-9525(93)90214-3  0.52
1993 Li C, Ramjeesingh M, Reyes E, Jensen T, Chang X, Rommens JM, Bear CE. The cystic fibrosis mutation (ΔF508) does not influence the chloride channel activity of CFTR Nature Genetics. 3: 311-316. PMID 7526932 DOI: 10.1038/ng0493-311  0.52
1992 Sood R, Bear C, Auerbach W, Reyes E, Jensen T, Kartner N, Riordan JR, Buchwald M. Regulation of CFTR expression function during differentiation of intestinal epithelial cells Embo Journal. 11: 2487-2494. PMID 1378393  0.52
1992 Bear CE, Li C, Kartner N, Bridges RJ, Jensen TJ, Ramjeesingh M, Riordan JR. Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR) Cell. 68: 809-818. PMID 1371239 DOI: 10.1016/0092-8674(92)90155-6  0.52
1992 Bear CE, Reyes EF. cAMP-activated chloride conductance in the colonic cell line, Caco-2 American Journal of Physiology - Cell Physiology. 262. PMID 1370744  0.52
1991 Bear CE. A K+-selective channel in the colonic carcinoma cell line: CaCo-2 is activated with membrane stretch Bba - Biomembranes. 1069: 267-272. PMID 1932066 DOI: 10.1016/0005-2736(91)90134-T  0.52
1991 Bear CE. Regulation of ion conductance in human skin fibroblasts Advances in Experimental Medicine and Biology. 290: 273-286. PMID 1719764  0.52
1991 Bear CE, Duguay F, Naismith AL, Kartner N, Hanrahan JW, Riordan JR. Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene Journal of Biological Chemistry. 266: 19142-19145. PMID 1717461  0.52
1991 Rommens JM, Dho S, Bear CE, Kartner N, Kennedy D, Riordan JR, Tsui LC, Foskett JK. cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic fibrosis transmembrane conductance regulator Proceedings of the National Academy of Sciences of the United States of America. 88: 7500-7504. PMID 1715567  0.52
1991 Kartner N, Hanrahan JW, Jensen TJ, Naismith AL, Sun S, Ackerley CA, Reyes EF, Tsui LC, Rommens JM, Bear CE, Riordan JR. Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance Cell. 64: 681-691. PMID 1705179 DOI: 10.1016/0092-8674(91)90498-N  0.52
1991 Bear CE, Li C. Calcium-permeable channels in rat hepatoma cells are activated by extracellular nucleotides American Journal of Physiology - Cell Physiology. 261. PMID 1662901  0.52
1990 Bear CE. A nonselective cation channel in rat liver cells is activated by membrane stretch American Journal of Physiology - Cell Physiology. 258. PMID 1690515  0.52
1989 ROTHSTEIN A, BEAR C. Cell Volume Changes and the Activity of the Chloride Conductance Path Annals of the New York Academy of Sciences. 574: 294-308. PMID 2561323 DOI: 10.1111/j.1749-6632.1989.tb25166.x  0.52
1988 Bear CE, Davison JS, Shaffer EA. Intracellular pH influences the resting membrane potential of isolated rat hepatocytes. Biochimica Et Biophysica Acta. 944: 113-20. PMID 3179283 DOI: 10.1016/0005-2736(88)90424-5  0.52
1988 Bear CE, Shaffer EA. Hepatocellular water and electrolyte solution Canadian Journal of Physiology and Pharmacology. 66: 1253-1260. PMID 3071394 DOI: 10.1139/y88-206  0.52
1988 Bear CE. Phosphorylation-activated chloride channels in human skin fibroblasts Febs Letters. 237: 145-149. PMID 2458964 DOI: 10.1016/0014-5793(88)80189-3  0.52
1987 Bear C, Shaffer EA, Davison JS. The electrogenic effect of sodium taurocholate on rat hepatocyte couplets. Proceedings of the Western Pharmacology Society. 30: 109-11. PMID 3628259  0.52
1987 Minuk GY, Bear CE, Sarjeant EJ. Sodium-independent, bicuculline-sensitive [3H]GABA binding to isolated rat hepatocytes American Journal of Physiology - Gastrointestinal and Liver Physiology. 252. PMID 3578523  0.52
1987 Bear CE, Petersen OH. L-alanine evokes opening of single Ca2+-activated K+ channels in rat liver cells PflüGers Archiv European Journal of Physiology. 410: 342-344. PMID 2446259 DOI: 10.1007/BF00580288  0.52
1987 Bear CE, Davison JS, Shaffer EA. Sodium-dependent taurocholate uptake by isolated rat hepatocytes occurs through an electrogenic mechanism. Biochimica Et Biophysica Acta. 903: 388-94. PMID 2443174 DOI: 10.1016/0005-2736(87)90230-6  0.52
1986 Strasberg SM, Ilson RG, Bear CE. Bile salt dependent bile flow in the rabbit: Evidence for the importance of an amiloride inhibitable pathway Canadian Journal of Physiology and Pharmacology. 64: 1316-1320. PMID 3801986  0.52
1986 Bear CE, Petrunka CN, Strasberg SM. Effect of sodium taurocholate on amiloride-inhibitable sodium uptake and on intracellular pH of isolated rat hepatocytes Journal of Laboratory and Clinical Medicine. 108: 109-116. PMID 3734584  0.52
1986 Petersen OH, Bear C. Physiology: Two glucagon transducing systems Nature. 323: 18. PMID 3018585 DOI: 10.1038/323018a0  0.52
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