Kay Huebner - Publications

Affiliations: 
Integrated Biomedical Science Graduate Program Ohio State University, Columbus, Columbus, OH 
Area:
Cell Biology, Molecular Biology, Genetics, Biomedical Engineering, Biochemistry

120 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Druck T, Cheung DG, Park D, Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Raso C, Green K, Huebner K, Croce CM. Fhit-Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells. Cell Death & Disease. 10: 147. PMID 30770797 DOI: 10.1038/s41419-019-1414-7  0.48
2018 Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, Zhang F, Solow-Cordero D, Saldivar JC, Austin ED, Loyd JE, Wheeler L, Andruska A, Donato M, Wang L, ... Huebner K, et al. Fragile Histidine Triad (FHIT), a Novel Modifier Gene in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. PMID 30107138 DOI: 10.1164/rccm.201712-2553OC  0.44
2017 Volinia S, Druck T, Paisie CA, Schrock MS, Huebner K. The ubiquitous 'cancer mutational signature' 5 occurs specifically in cancers with deleted FHIT alleles. Oncotarget. 8: 102199-102211. PMID 29254236 DOI: 10.18632/oncotarget.22321  0.72
2017 Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, ... Huebner K, et al. Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. The Journal of Biological Chemistry. 292: 14279. PMID 28842474 DOI: 10.1074/jbc.A117.709062  0.48
2017 Karras JR, Schrock MS, Batar B, Huebner K. Fragile Genes That Are Frequently Altered in Cancer: Players Not Passengers. Cytogenetic and Genome Research. PMID 28199992 DOI: 10.1159/000455753  0.72
2017 Kiss DL, Waters CE, Ouda IM, Saldivar JC, Karras JR, Amin ZA, Mahrous S, Druck T, Bundschuh RA, Schoenberg DR, Huebner K. Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression. Biochimica Et Biophysica Acta. PMID 28093273 DOI: 10.1016/j.bbagrm.2017.01.005  0.48
2016 Schrock MS, Karras JR, Guggenbiller MJ, Druck T, Batar B, Huebner K. Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch. Advances in Biological Regulation. PMID 27773744 DOI: 10.1016/j.jbior.2016.09.008  0.72
2016 Karras JR, Schrock MS, Batar B, Zhang J, La Perle K, Druck T, Huebner K. Fhit loss-associated initiation and progression of neoplasia in vitro. Cancer Science. PMID 27513973 DOI: 10.1111/cas.13032  0.72
2016 Sun J, Shen R, Schrock MS, Liu J, Pan X, Quimby D, Zanesi N, Druck T, Fong LY, Huebner K. Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation. Cancer Medicine. PMID 27185213 DOI: 10.1002/cam4.768  0.72
2016 Paisie CA, Schrock MS, Karras JR, Zhang J, Miuma S, Ouda IM, Waters CE, Saldivar JC, Druck T, Huebner K. Exome-wide single-base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse. Cancer Science. PMID 26782170 DOI: 10.1111/cas.12887  0.72
2015 Drasin DJ, Guarnieri AL, Neelakantan D, Kim J, Cabrera JH, Wang CA, Zaberezhnyy V, Gasparini P, Cascione L, Huebner K, Tan AC, Ford HL. TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation. Cancer Research. 75: 1908-21. PMID 25716682 DOI: 10.1158/0008-5472.CAN-14-2394  0.72
2015 Schrock MS, Huebner K. WWOX: a fragile tumor suppressor. Experimental Biology and Medicine (Maywood, N.J.). 240: 296-304. PMID 25538133 DOI: 10.1177/1535370214561590  0.72
2015 Waters CE, Saldivar JC, Amin ZA, Schrock MS, Huebner K. FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis. Oncotarget. 6: 3409-19. PMID 25401976 DOI: 10.18632/oncotarget.2636  0.72
2015 Cirombella R, Montrone G, Stoppacciaro A, Giglio S, Volinia S, Graziano P, Huebner K, Vecchione A. Corrigendum to "Fhit loss in lung preneoplasia: Relation to DNA damage response checkpoint activation" [Cancer Lett. 291 (2) (2010) 230-236] DOI: 10.1016/j.canlet.2009.10.017 Cancer Letters. 369: 259. DOI: 10.1016/j.canlet.2015.09.001  0.72
2015 Waters CE, Saldivar JC, Amin ZA, Schrock MS, Huebner K. FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis Oncotarget. 6: 3409-3419.  0.72
2014 Suh SS, Yoo JY, Cui R, Kaur B, Huebner K, Lee TK, Aqeilan RI, Croce CM. FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs. Plos Genetics. 10: e1004652. PMID 25340791 DOI: 10.1371/journal.pgen.1004652  0.72
2014 Volinia S, Nuovo G, Drusco A, Costinean S, Abujarour R, Desponts C, Garofalo M, Baffa R, Aeqilan R, Maharry K, Sana ME, Garzon ME, Di Leva G, Gasparini P, Dama P, ... ... Huebner KF, et al. Pluripotent stem cell miRNAs and metastasis in invasive breast cancer. Journal of the National Cancer Institute. 106. PMID 25306216 DOI: 10.1093/jnci/dju324  0.72
2014 Waters CE, Saldivar JC, Hosseini SA, Huebner K. The FHIT gene product: Tumor suppressor and genome "caretaker" Cellular and Molecular Life Sciences. 71: 4577-4587. PMID 25283145 DOI: 10.1007/s00018-014-1722-0  0.72
2014 Karras JR, Paisie CA, Huebner K. Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis. Cancers. 6: 1208-19. PMID 24901304 DOI: 10.3390/cancers6021208  0.72
2014 Gasparini P, Cascione L, Fassan M, Lovat F, Guler G, Balci S, Irkkan C, Morrison C, Croce CM, Shapiro CL, Huebner K. microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers. Oncotarget. 5: 1174-84. PMID 24632568  0.72
2014 Gasparini P, Lovat F, Fassan M, Casadei L, Cascione L, Jacob NK, Carasi S, Palmieri D, Costinean S, Shapiro CL, Huebner K, Croce CM. Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation. Proceedings of the National Academy of Sciences of the United States of America. 111: 4536-41. PMID 24616504 DOI: 10.1073/pnas.1402604111  0.72
2014 Harshman SW, Hoover ME, Huang C, Branson OE, Chaney SB, Cheney CM, Rosol TJ, Shapiro CL, Wysocki VH, Huebner K, Freitas MA. Histone H1 phosphorylation in breast cancer. Journal of Proteome Research. 13: 2453-67. PMID 24601643 DOI: 10.1021/pr401248f  0.72
2014 Gasparini P, Fassan M, Cascione L, Guler G, Balci S, Irkkan C, Paisie C, Lovat F, Morrison C, Zhang J, Scarpa A, Croce CM, Shapiro CL, Huebner K. Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options. Plos One. 9: e88525. PMID 24505496 DOI: 10.1371/journal.pone.0088525  0.72
2013 Miuma S, Saldivar JC, Karras JR, Waters CE, Paisie CA, Wang Y, Jin V, Sun J, Druck T, Zhang J, Huebner K. Fhit deficiency-induced global genome instability promotes mutation and clonal expansion. Plos One. 8: e80730. PMID 24244712 DOI: 10.1371/journal.pone.0080730  0.72
2013 Hosseini SA, Horton S, Saldivar JC, Miuma S, Stampfer MR, Heerema NA, Huebner K. Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability. Genes, Chromosomes & Cancer. 52: 1017-29. PMID 23929738 DOI: 10.1002/gcc.22097  0.72
2013 Cascione L, Gasparini P, Lovat F, Carasi S, Pulvirenti A, Ferro A, Alder H, He G, Vecchione A, Croce CM, Shapiro CL, Huebner K. Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer. Plos One. 8: e55910. PMID 23405235 DOI: 10.1371/journal.pone.0055910  0.72
2013 Saldivar JC, Bene J, Hosseini SA, Miuma S, Horton S, Heerema NA, Huebner K. Characterization of the role of Fhit in suppression of DNA damage. Advances in Biological Regulation. 53: 77-85. PMID 23102829 DOI: 10.1016/j.jbior.2012.10.003  0.72
2012 Saldivar JC, Miuma S, Bene J, Hosseini SA, Shibata H, Sun J, Wheeler LJ, Mathews CK, Huebner K. Initiation of genome instability and preneoplastic processes through loss of Fhit expression. Plos Genetics. 8: e1003077. PMID 23209436 DOI: 10.1371/journal.pgen.1003077  0.72
2012 Alder H, Taccioli C, Chen H, Jiang Y, Smalley KJ, Fadda P, Ozer HG, Huebner K, Farber JL, Croce CM, Fong LY. Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. Carcinogenesis. 33: 1736-44. PMID 22689922 DOI: 10.1093/carcin/bgs204  0.72
2012 Guler G, Balci S, Costinean S, Ussakli CH, Irkkan C, Suren D, Sari E, Altundag K, Ozisik Y, Jones S, Bacher J, Shapiro CL, Huebner K. Stem cell-related markers in primary breast cancers and associated metastatic lesions. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 25: 949-55. PMID 22388757 DOI: 10.1038/modpathol.2012.37  0.72
2012 Volinia S, Galasso M, Sana ME, Wise TF, Palatini J, Huebner K, Croce CM. Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA. Proceedings of the National Academy of Sciences of the United States of America. 109: 3024-9. PMID 22315424 DOI: 10.1073/pnas.1200010109  0.72
2011 Shibata H, Miuma S, Saldivar JC, Huebner K. Response of subtype-specific human breast cancer-derived cells to poly(ADP-ribose) polymerase and checkpoint kinase 1 inhibition. Cancer Science. 102: 1882-8. PMID 21707865 DOI: 10.1111/j.1349-7006.2011.02016.x  0.72
2011 Drusco A, Pekarsky Y, Costinean S, Antenucci A, Conti L, Volinia S, Aqeilan RI, Huebner K, Zanesi N. Common fragile site tumor suppressor genes and corresponding mouse models of cancer. Journal of Biomedicine & Biotechnology. 2011: 984505. PMID 21318118 DOI: 10.1155/2011/984505  0.72
2011 Huebner K. Molecular biology: DNA fragility put into context. Nature. 470: 46-7. PMID 21293366 DOI: 10.1038/470046a  0.72
2011 Fong LY, Jiang Y, Rawahneh ML, Smalley KJ, Croce CM, Farber JL, Huebner K. Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. Carcinogenesis. 32: 554-60. PMID 21245412 DOI: 10.1093/carcin/bgr004  0.72
2011 Sun J, Liu J, Pan X, Quimby D, Zanesi N, Druck T, Pfeifer GP, Croce CM, Fong LY, Huebner K. Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains. Carcinogenesis. 32: 351-8. PMID 21097531 DOI: 10.1093/carcin/bgq251  0.72
2011 Guler G, Himmetoglu C, Jimenez RE, Geyer SM, Wang WP, Costinean S, Pilarski RT, Morrison C, Suren D, Liu J, Chen J, Kamal J, Shapiro CL, Huebner K. Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical features Breast Cancer Research and Treatment. 129: 421-432. PMID 21069451 DOI: 10.1007/s10549-010-1248-6  0.72
2011 Huebner K, Saldivar JC, Sun J, Shibata H, Druck T. Hits, Fhits and Nits: beyond enzymatic function. Advances in Enzyme Regulation. 51: 208-17. PMID 21035495 DOI: 10.1016/j.advenzreg.2010.09.003  0.72
2010 Volinia S, Galasso M, Costinean S, Tagliavini L, Gamberoni G, Drusco A, Marchesini J, Mascellani N, Sana ME, Abu Jarour R, Desponts C, Teitell M, Baffa R, Aqeilan R, Iorio MV, ... ... Huebner K, et al. Reprogramming of miRNA networks in cancer and leukemia. Genome Research. 20: 589-99. PMID 20439436 DOI: 10.1101/gr.098046.109  0.72
2010 Salah Z, Aqeilan R, Huebner K. WWOX gene and gene product: tumor suppression through specific protein interactions. Future Oncology (London, England). 6: 249-59. PMID 20146584 DOI: 10.2217/fon.09.152  0.72
2010 Saldivar JC, Shibata H, Huebner K. Pathology and biology associated with the fragile FHIT gene and gene product. Journal of Cellular Biochemistry. 109: 858-65. PMID 20082323 DOI: 10.1002/jcb.22481  0.72
2010 Dincer N, Tezel GG, Sungur A, Himmetoglu C, Huebner K, Güler G. Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland. Oral Oncology. 46: 195-9. PMID 20060354 DOI: 10.1016/j.oraloncology.2009.12.003  0.72
2010 Cirombella R, Montrone G, Stoppacciaro A, Giglio S, Volinia S, Graziano P, Huebner K, Vecchione A. Fhit loss in lung preneoplasia: relation to DNA damage response checkpoint activation. Cancer Letters. 291: 230-6. PMID 19931269 DOI: 10.1016/j.canlet.2009.10.017  0.72
2009 Rimessi A, Marchi S, Fotino C, Romagnoli A, Huebner K, Croce CM, Pinton P, Rizzuto R. Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 106: 12753-8. PMID 19622739 DOI: 10.1073/pnas.0906484106  0.72
2009 Krasnikov BF, Chien CH, Nostramo R, Pinto JT, Nieves E, Callaway M, Sun J, Huebner K, Cooper AJ. Identification of the putative tumor suppressor Nit2 as omega-amidase, an enzyme metabolically linked to glutamine and asparagine transamination. Biochimie. 91: 1072-80. PMID 19595734 DOI: 10.1016/j.biochi.2009.07.003  0.72
2009 Okumura H, Ishii H, Pichiorri F, Croce CM, Mori M, Huebner K. Fragile gene product, Fhit, in oxidative and replicative stress responses. Cancer Science. 100: 1145-50. PMID 19486340 DOI: 10.1111/j.1349-7006.2009.01168.x  0.72
2009 Sun J, Okumura H, Yearsley M, Frankel W, Fong LY, Druck T, Huebner K. Nit1 and Fhit tumor suppressor activities are additive. Journal of Cellular Biochemistry. 107: 1097-106. PMID 19479888 DOI: 10.1002/jcb.22207  0.72
2009 Bloomston M, Kneile J, Butterfield M, Dillhoff M, Muscarella P, Ellison EC, Melvin WS, Croce CM, Pichiorri F, Huebner K, Frankel WL. Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features. Annals of Surgical Oncology. 16: 2331-8. PMID 19434452 DOI: 10.1245/s10434-009-0507-4  0.72
2009 Zhang H, Hou YJ, Han SY, Zhang EC, Huebner K, Zhang J. Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells. International Immunology. 21: 691-703. PMID 19395373 DOI: 10.1093/intimm/dxp038  0.72
2009 Guler G, Huebner K, Himmetoglu C, Jimenez RE, Costinean S, Volinia S, Pilarski RT, Hayran M, Shapiro CL. Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer. Cancer. 115: 899-908. PMID 19130459 DOI: 10.1002/cncr.24103  0.72
2009 Pichiorri F, Okumura H, Nakamura T, Garrison PN, Gasparini P, Suh SS, Druck T, McCorkell KA, Barnes LD, Croce CM, Huebner K. Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions. The Journal of Biological Chemistry. 284: 1040-9. PMID 19004824 DOI: 10.1074/jbc.M806638200  0.72
2008 Pichiorri F, Palumbo T, Suh SS, Okamura H, Trapasso F, Ishii H, Huebner K, Croce CM. Fhit tumor suppressor: guardian of the preneoplastic genome. Future Oncology (London, England). 4: 815-24. PMID 19086848 DOI: 10.2217/14796694.4.6.815  0.72
2008 Ishii H, Mimori K, Ishikawa K, Okumura H, Pichiorri F, Druck T, Inoue H, Vecchione A, Saito T, Mori M, Huebner K. Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes. Cancer Research. 68: 3662-70. PMID 18483248 DOI: 10.1158/0008-5472.CAN-07-5687  0.72
2008 Nakayama S, Semba S, Maeda N, Aqeilan RI, Huebner K, Yokozaki H. Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells. Cancer Science. 99: 1370-6. PMID 18460020 DOI: 10.1111/j.1349-7006.2008.00841.x  0.72
2008 Pichiorri F, Ishii H, Okumura H, Trapasso F, Wang Y, Huebner K. Molecular parameters of genome instability: roles of fragile genes at common fragile sites. Journal of Cellular Biochemistry. 104: 1525-33. PMID 18393361 DOI: 10.1002/jcb.21560  0.72
2008 Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, ... Huebner K, et al. Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells. The Journal of Biological Chemistry. 283: 13736-44. PMID 18319262 DOI: 10.1074/jbc.M709062200  0.72
2007 McCorkell KA, Mancini R, Siprashvili Z, Barnoski BL, Iliopoulos D, Siracusa LD, Zanesi N, Croce CM, Fong LY, Druck T, Huebner K. Influence of a nonfragile FHIT transgene on murine tumor susceptibility. Cytogenetic and Genome Research. 118: 196-203. PMID 18000371 DOI: 10.1159/000108301  0.72
2007 Guler G, Iliopoulos D, Guler N, Himmetoglu C, Hayran M, Huebner K. Wwox and Ap2gamma expression levels predict tamoxifen response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 6115-21. PMID 17947476 DOI: 10.1158/1078-0432.CCR-07-1282  0.72
2007 Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, Liu S, Alder H, Costinean S, Fernandez-Cymering C, Volinia S, Guler G, Morrison CD, Chan KK, Marcucci G, ... ... Huebner K, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proceedings of the National Academy of Sciences of the United States of America. 104: 15805-10. PMID 17890317 DOI: 10.1073/pnas.0707628104  0.72
2007 Qin HR, Iliopoulos D, Nakamura T, Costinean S, Volinia S, Druck T, Sun J, Okumura H, Huebner K. Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling. Molecular Cancer Research : McR. 5: 957-65. PMID 17704139 DOI: 10.1158/1541-7786.MCR-07-0211  0.72
2007 Ishii H, Wang Y, Huebner K. A Fhit-ing role in the DNA damage checkpoint response. Cell Cycle (Georgetown, Tex.). 6: 1044-8. PMID 17457056  0.72
2007 Iliopoulos D, Fabbri M, Druck T, Qin HR, Han SY, Huebner K. Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 268-74. PMID 17200365 DOI: 10.1158/1078-0432.CCR-06-2038  0.72
2007 Cantor JP, Iliopoulos D, Rao AS, Druck T, Semba S, Han SY, McCorkell KA, Lakshman TV, Collins JE, Wachsberger P, Friedberg JS, Huebner K. Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. International Journal of Cancer. Journal International Du Cancer. 120: 24-31. PMID 17019711 DOI: 10.1002/ijc.22073  0.72
2007 Guler G, Huebner K. Discussion on the use of taxanes for treatment of breast cancers in BRCA1 mutations carriers Hereditary Cancer in Clinical Practice. 5: 122-123.  0.72
2006 Ishii H, Mimori K, Inoue H, Inageta T, Ishikawa K, Semba S, Druck T, Trapasso F, Tani K, Vecchione A, Croce CM, Mori M, Huebner K. Fhit modulates the DNA damage checkpoint response. Cancer Research. 66: 11287-92. PMID 17145874 DOI: 10.1158/0008-5472.CAN-06-2503  0.72
2006 Semba S, Huebner K. Protein expression profiling identifies cyclophilin A as a molecular target in Fhit-mediated tumor suppression. Molecular Cancer Research : McR. 4: 529-38. PMID 16885564 DOI: 10.1158/1541-7786.MCR-06-0060  0.72
2006 Semba S, Han SY, Qin HR, McCorkell KA, Iliopoulos D, Pekarsky Y, Druck T, Trapasso F, Croce CM, Huebner K. Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor. The Journal of Biological Chemistry. 281: 28244-53. PMID 16864578 DOI: 10.1074/jbc.M603590200  0.72
2006 Qin HR, Iliopoulos D, Semba S, Fabbri M, Druck T, Volinia S, Croce CM, Morrison CD, Klein RD, Huebner K. A role for the WWOX gene in prostate cancer. Cancer Research. 66: 6477-81. PMID 16818616 DOI: 10.1158/0008-5472.CAN-06-0956  0.72
2006 Pichiorri F, Trapasso F, Palumbo T, Aqeilan RI, Drusco A, Blaser BW, Iliopoulos D, Caligiuri MA, Huebner K, Croce CM. Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 3494-501. PMID 16740775 DOI: 10.1158/1078-0432.CCR-05-2581  0.72
2006 Semba S, Trapasso F, Fabbri M, McCorkell KA, Volinia S, Druck T, Iliopoulos D, Pekarsky Y, Ishii H, Garrison PN, Barnes LD, Croce CM, Huebner K. Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential. Oncogene. 25: 2860-72. PMID 16407838 DOI: 10.1038/sj.onc.1209323  0.72
2006 Iliopoulos D, Guler G, Han SY, Druck T, Ottey M, McCorkell KA, Huebner K. Roles of FHIT and WWOX fragile genes in cancer. Cancer Letters. 232: 27-36. PMID 16225988 DOI: 10.1016/j.canlet.2005.06.048  0.72
2006 Huebner K, Zhang J. Stable symmetry feature detection and classification in panoramic robot vision systems Ieee International Conference On Intelligent Robots and Systems. 3429-3434. DOI: 10.1109/IROS.2006.282581  0.36
2006 Huebner K, Westhoff D, Zhang J. A comparison of regional feature detectors in panoramic images Proceedings of Ieee Icia 2006 - 2006 Ieee International Conference On Information Acquisition. 666-671. DOI: 10.1109/ICIA.2006.305806  0.36
2005 Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, Croce CM. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 15611-6. PMID 16223882 DOI: 10.1073/pnas.0505485102  0.72
2005 Hu B, Wang H, Wang X, Lu HR, Huang C, Powell SN, Huebner K, Wang Y. Fhit and CHK1 have opposing effects on homologous recombination repair. Cancer Research. 65: 8613-6. PMID 16204026 DOI: 10.1158/0008-5472.CAN-05-1966  0.72
2005 Liu CG, Zhang L, Jiang Y, Chatterjee D, Croce CM, Huebner K, Fong LY. Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment. Cancer Research. 65: 7790-9. PMID 16140947 DOI: 10.1158/0008-5472.CAN-05-1345  0.72
2005 Zanesi N, Mancini R, Sevignani C, Vecchione A, Kaou M, Valtieri M, Calin GA, Pekarsky Y, Gnarra JR, Croce CM, Huebner K. Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. Cancer Research. 65: 6576-82. PMID 16061637 DOI: 10.1158/0008-5472.CAN-05-1128  0.72
2005 Guler G, Uner A, Guler N, Han SY, Iliopoulos D, McCue P, Huebner K. Concordant loss of fragile gene expression early in breast cancer development. Pathology International. 55: 471-8. PMID 15998374 DOI: 10.1111/j.1440-1827.2005.01855.x  0.72
2005 Ishii H, Inageta T, Mimori K, Saito T, Sasaki H, Isobe M, Mori M, Croce CM, Huebner K, Ozawa K, Furukawa Y. Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 9655-60. PMID 15983387 DOI: 10.1073/pnas.0504222102  0.72
2005 Guler G, Iliopoulos D, Han SY, Fong LY, Lubet RA, Grubbs CJ, Huebner K. Hypermethylation patterns in the Fhit regulatory region are tissue specific. Molecular Carcinogenesis. 43: 175-81. PMID 15937960 DOI: 10.1002/mc.20100  0.72
2005 Iliopoulos D, Guler G, Han SY, Johnston D, Druck T, McCorkell KA, Palazzo J, McCue PA, Baffa R, Huebner K. Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer. Oncogene. 24: 1625-33. PMID 15674328 DOI: 10.1038/sj.onc.1208398  0.72
2005 Lubet RA, Huebner K, Fong LY, Altieri DC, Steele VE, Kopelovich L, Kavanaugh C, Juliana MM, Soong SJ, Grubbs CJ. 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin. Carcinogenesis. 26: 571-8. PMID 15591090 DOI: 10.1093/carcin/bgh352  0.72
2005 Hu B, Han SY, Wang X, Ottey M, Potoczek MB, Dicker A, Huebner K, Wang Y. Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway. Journal of Cellular Physiology. 202: 518-23. PMID 15389587 DOI: 10.1002/jcp.20139  0.72
2005 Westhoff D, Zhang J, Huebner K. Robust illumination-invariant features by quantitative bilateral symmetry detection Icia 2005 - Proceedings of 2005 International Conference On Information Acquisition. 2005: 48-53.  0.36
2004 Ottey M, Han SY, Druck T, Barnoski BL, McCorkell KA, Croce CM, Raventos-Suarez C, Fairchild CR, Wang Y, Huebner K. Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant British Journal of Cancer. 91: 1669-1677. PMID 15494723 DOI: 10.1038/sj.bjc.6602058  0.72
2004 Fujishita T, Doi Y, Sonoshita M, Hiai H, Oshima M, Huebner K, Croce CM, Taketo MM. Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice British Journal of Cancer. 91: 1571-1574. PMID 15467769  0.72
2004 Ishii H, Vecchione A, Furukawa Y, Croce CM, Huebner K, Fong LY. Differentially expressed genes execute zinc-induced apoptosis in precancerous esophageal epithelium of zinc-deficient rats. Oncogene. 23: 8040-8. PMID 15361827 DOI: 10.1038/sj.onc.1207974  0.72
2004 Matsuyama A, Croce CM, Huebner K. Common fragile genes European Journal of Histochemistry. 48: 29-35. PMID 15145773  0.72
2004 Aqeilan RI, Kuroki T, Pekarsky Y, Albagha O, Trapasso F, Baffa R, Huebner K, Edmonds P, Croce CM. Loss of WWOX expression in gastric carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3053-8. PMID 15131042 DOI: 10.1158/1078-0432.CCR-03-0594  0.72
2004 Guler G, Uner A, Guler N, Han SY, Iliopoulos D, Hauck WW, McCue P, Huebner K. The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer. 100: 1605-14. PMID 15073846 DOI: 10.1002/cncr.20137  0.72
2004 Aqeilan RI, Pekarsky Y, Herrero JJ, Palamarchuk A, Letofsky J, Druck T, Trapasso F, Han SY, Melino G, Huebner K, Croce CM. Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proceedings of the National Academy of Sciences of the United States of America. 101: 4401-6. PMID 15070730 DOI: 10.1073/pnas.0400805101  0.72
2004 Ishii H, Vecchione A, Fong LY, Zanesi N, Trapasso F, Furukawa Y, Baffa R, Huebner K, Croce CM. Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses. Current Gene Therapy. 4: 53-63. PMID 15032614 DOI: 10.2174/1566523044578031  0.72
2004 Han SY, Iliopoulos D, Druck T, Guler G, Grubbs CJ, Pereira M, Zhang Z, You M, Lubet RA, Fong LY, Huebner K. CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors. Oncogene. 23: 3990-8. PMID 15007387 DOI: 10.1038/sj.onc.1207526  0.72
2004 Pekarsky Y, Garrison PN, Palamarchuk A, Zanesi N, Aqeilan RI, Huebner K, Barnes LD, Croce CM. Fhit is a physiological target of the protein kinase Src. Proceedings of the National Academy of Sciences of the United States of America. 101: 3775-9. PMID 15007172 DOI: 10.1073/pnas.0400481101  0.72
2003 Ishii H, Vecchione A, Furukawa Y, Sutheesophon K, Han SY, Druck T, Kuroki T, Trapasso F, Nishimura M, Saito Y, Ozawa K, Croce CM, Huebner K, Furukawa Y. Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Molecular Cancer Research : McR. 1: 940-7. PMID 14638866  0.72
2003 Matsuyama A, Shiraishi T, Trapasso F, Kuroki T, Alder H, Mori M, Huebner K, Croce CM. Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic. Proceedings of the National Academy of Sciences of the United States of America. 100: 14988-93. PMID 14630947 DOI: 10.1073/pnas.2336256100  0.72
2003 Ishii H, Zanesi N, Vecchione A, Trapasso F, Yendamuri S, Sarti M, Baffa R, During MJ, Huebner K, Fong LY, Croce CM. Regression of upper gastric cancer in mice by FHIT gene delivery. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1768-70. PMID 12958204 DOI: 10.1096/fj.03-0241fje  0.72
2003 Fong LY, Mancini R, Nakagawa H, Rustgi AK, Huebner K. Combined cyclin D1 overexpression and zinc deficiency disrupts cell cycle and accelerates mouse forestomach carcinogenesis. Cancer Research. 63: 4244-52. PMID 12874033  0.72
2003 Huebner K, Croce CM. Cancer and the FRA3B/FHIT fragile locus: It's a HIT British Journal of Cancer. 88: 1501-1506. PMID 12771912 DOI: 10.1038/sj.bjc.6600937  0.72
2003 Korsisaari N, Rossi DJ, Luukko K, Huebner K, Henkemeyer M, Mäkelä TP. The histidine triad protein Hint is not required for murine development or Cdk7 function. Molecular and Cellular Biology. 23: 3929-35. PMID 12748294 DOI: 10.1128/MCB.23.11.3929-3935.2003  0.72
2003 Han SY, Druck T, Huebner K. Candidate tumor suppressor genes at FRA7G are coamplified with MET and do not suppress malignancy in a gastric cancer. Genomics. 81: 105-7. PMID 12620387 DOI: 10.1016/S0888-7543(02)00029-0  0.72
2003 Yendamuri S, Kuroki T, Trapasso F, Henry AC, Dumon KR, Huebner K, Williams NN, Kaiser LR, Croce CM. WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer. Cancer Research. 63: 878-81. PMID 12591741  0.72
2003 Trapasso F, Krakowiak A, Cesari R, Arkles J, Yendamuri S, Ishii H, Vecchione A, Kuroki T, Bieganowski P, Pace HC, Huebner K, Croce CM, Brenner C. Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding. Proceedings of the National Academy of Sciences of the United States of America. 100: 1592-7. PMID 12574506 DOI: 10.1073/pnas.0437915100  0.72
2003 Fong LY, Ishii H, Nguyen VT, Vecchione A, Farber JL, Croce CM, Huebner K. p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice. Cancer Research. 63: 186-95. PMID 12517797  0.72
2002 Pekarsky Y, Zanesi N, Palamarchuk A, Huebner K, Croce CM. FHIT: from gene discovery to cancer treatment and prevention. The Lancet. Oncology. 3: 748-54. PMID 12473516 DOI: 10.1016/S1470-2045(02)00931-2  0.72
2002 Pekarsky Y, Palamarchuk A, Huebner K, Croce CM. FHIT as tumor suppressor: mechanisms and therapeutic opportunities. Cancer Biology & Therapy. 1: 232-6. PMID 12432269  0.72
2002 Turner BC, Ottey M, Zimonjic DB, Potoczek M, Hauck WW, Pequignot E, Keck-Waggoner CL, Sevignani C, Aldaz CM, McCue PA, Palazzo J, Huebner K, Popescu NC. The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers. Cancer Research. 62: 4054-60. PMID 12124341  0.72
2002 Zhang J, Huebner K. Using symmetry as a feature in panoramic images for mobile robot Applications Vdi Berichte. 263-268.  0.36
2001 Hadaczek P, Gronwald J, Chosia M, Huebner K, Lubiński J. Fhit protein expression in endometrial cancers: No correlation with histological grade Polish Journal of Pathology. 52: 199-203. PMID 11915181  0.72
2001 Huebner K, Croce CM. FRA3B and other common fragile sites: The weakest links Nature Reviews Cancer. 1: 214-221. PMID 11902576  0.72
2001 Podolski J, Byrski T, Zajaczek S, Druck T, Zimonjic DB, Popescu NC, Kata G, Borowka A, Gronwald J, Lubinski J, Huebner K. Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation Journal of Human Genetics. 46: 685-693. PMID 11776380 DOI: 10.1007/s100380170001  0.72
2001 Hadaczek P, Dȩbniak T, Kurzawski G, Jakubowska A, Huzarski T, Huebner K, Lubiński J. Fhit protein expression in hereditary and sporadic colorectal cancers Polish Journal of Pathology. 52: 125-132. PMID 11769399  0.72
2001 Huebner K. Tumor suppressors on 3p: A neoclassic quartet Proceedings of the National Academy of Sciences of the United States of America. 98: 14763-14765. PMID 11752421 DOI: 10.1073/pnas.261586598  0.72
2001 van Heerden WF, Swart TJ, Robson B, Smith TL, Engelbrecht S, van Heerden MB, van Rensburg EJ, Huebner K. FHIT RNA and protein expression in oral squamous cell carcinomas. Anticancer Research. 21: 2425-8. PMID 11724302  0.72
2001 Van Heerden WFP, Swart TJP, Van Heerden MB, Pekarsky Y, Sutherland R, Huebner K. Fhit protein expression in oral epithelium: Immunohistochemical evaluation of three antisera Anticancer Research. 21: 2419-2423. PMID 11724301  0.72
2001 Ishii H, Dumon KR, Vecchione A, Fong LYY, Baffa R, Huebner K, Croce CM. Potential cancer therapy with the fragile histidine triad gene: Review of the preclinical studies Journal of the American Medical Association. 286: 2441-2449. PMID 11712940  0.72
2001 Druck T, Podolski J, Byrski T, Wyrwicz L, Zajaczek S, Kata G, Borowka A, Lubinski J, Huebner K. The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation Journal of Human Genetics. 46: 583-589. PMID 11587072 DOI: 10.1007/s100380170025  0.72
2001 Zanesi N, Fidanza V, Fong LY, Mancini R, Druck T, Valtieri M, Rüdiger T, McCue PA, Croce CM, Huebner K. The tumor spectrum in FHIT-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 10250-5. PMID 11517343 DOI: 10.1073/pnas.191345898  0.72
2001 Powell D.J. J, Russell JP, Li G, Kuo BA, Fidanza V, Huebner K, Rothstein JL. Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53-/- mice Oncogene. 20: 3235-3246. PMID 11423973 DOI: 10.1038/sj.onc.1204425  0.72
2001 Dumon KR, Ishii H, Vecchione A, Trapasso F, Baldassarre G, Chakrani F, Druck T, Rosato EF, Williams NN, Baffa R, During MJ, Huebner K, Croce CM. Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer. Cancer Research. 61: 4827-36. PMID 11406559  0.72
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