Nikolaus Heveker - Publications

Affiliations: 
Université de Montréal, Montréal, Canada 
Area:
Biochemistry

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Szpakowska M, Nevins AM, Meyrath M, Rhainds D, D'huys T, Guité-Vinet F, Dupuis N, Gauthier PA, Counson M, Kleist A, St-Onge G, Hanson J, Schols D, Volkman BF, Heveker N, et al. Different contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3. British Journal of Pharmacology. PMID 29272550 DOI: 10.1111/bph.14132  0.36
2017 Montpas N, St-Onge G, Nama N, Rhainds D, Benredjem B, Girard M, Hickson G, Pons V, Heveker N. Ligand-specific conformational transitions and intracellular transport required for atypical chemokine receptor 3-mediated chemokine scavenging. The Journal of Biological Chemistry. PMID 29180449 DOI: 10.1074/jbc.M117.814947  0.36
2017 Ziarek JJ, Kleist AB, London N, Raveh B, Montpas N, Bonneterre J, St-Onge G, DiCosmo-Ponticello CJ, Koplinski CA, Roy I, Stephens B, Thelen S, Veldkamp CT, Coffman FD, Cohen MC, ... ... Heveker N, et al. Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation. Science Signaling. 10. PMID 28325822 DOI: 10.1126/scisignal.aah5756  0.36
2016 Benredjem B, Girard M, Rhainds D, St-Onge G, Heveker N. Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with its Chemokine Ligands CXCL11 and CXCL12. The Journal of Biological Chemistry. PMID 27875312 DOI: 10.1074/jbc.M116.762252  0.36
2016 Mona CE, Besserer-Offroy É, Cabana J, Lefrançois M, Boulais PE, Lefebvre MR, Leduc R, Lavigne P, Heveker N, Marsault E, Escher E. Structure Activity Relationship and Signaling of New Chimeric CXCR4 Agonists. Journal of Medicinal Chemistry. PMID 27434274 DOI: 10.1021/acs.jmedchem.6b00566  0.64
2016 Bonneterre J, Montpas N, Boularan C, Galés C, Heveker N. Analysis of Arrestin Recruitment to Chemokine Receptors by Bioluminescence Resonance Energy Transfer Methods in Enzymology. 570: 131-153. DOI: 10.1016/bs.mie.2015.09.003  0.64
2015 Oishi S, Kuroyanagi T, Kubo T, Montpas N, Yoshikawa Y, Misu R, Kobayashi Y, Ohno H, Heveker N, Furuya T, Fujii N. Development of Novel CXC Chemokine Receptor 7 (CXCR7) Ligands: Selectivity Switch from CXCR4 Antagonists with a Cyclic Pentapeptide Scaffold. Journal of Medicinal Chemistry. PMID 26042340 DOI: 10.1021/acs.jmedchem.5b00216  0.64
2015 Montpas N, Cabana J, St-Onge G, Gravel S, Morin G, Kuroyanagi T, Lavigne P, Fujii N, Oishi S, Heveker N. Mode of binding of the cyclic agonist peptide TC14012 to CXCR7: identification of receptor and compound determinants. Biochemistry. 54: 1505-15. PMID 25669416 DOI: 10.1021/bi501526s  0.64
2014 Armando S, Quoyer J, Lukashova V, Maiga A, Percherancier Y, Heveker N, Pin JP, Prézeau L, Bouvier M. The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4509-23. PMID 25053617 DOI: 10.1096/fj.13-242446  0.64
2013 Dridi L, Seyrantepe V, Fougerat A, Pan X, Bonneil E, Thibault P, Moreau A, Mitchell GA, Heveker N, Cairo CW, Issad T, Hinek A, Pshezhetsky AV. Positive regulation of insulin signaling by neuraminidase 1. Diabetes. 62: 2338-46. PMID 23520133 DOI: 10.2337/db12-1825  0.64
2013 Leduc M, Hou X, Hamel D, Sanchez M, Quiniou C, Honoré JC, Roy O, Madaan A, Lubell W, Varma DR, Mancini J, Duhamel F, Peri KG, Pichette V, Heveker N, et al. Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R10-22. PMID 23152113 DOI: 10.1152/ajpregu.00138.2012  0.64
2012 Mysinger MM, Weiss DR, Ziarek JJ, Gravel S, Doak AK, Karpiak J, Heveker N, Shoichet BK, Volkman BF. Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4. Proceedings of the National Academy of Sciences of the United States of America. 109: 5517-22. PMID 22431600 DOI: 10.1073/pnas.1120431109  0.64
2011 Drury LJ, Ziarek JJ, Gravel S, Veldkamp CT, Takekoshi T, Hwang ST, Heveker N, Volkman BF, Dwinell MB. Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. Proceedings of the National Academy of Sciences of the United States of America. 108: 17655-60. PMID 21990345 DOI: 10.1073/pnas.1101133108  0.64
2011 Lefrançois M, Lefebvre MR, Saint-Onge G, Boulais PE, Lamothe S, Leduc R, Lavigne P, Heveker N, Escher E. Agonists for the Chemokine Receptor CXCR4. Acs Medicinal Chemistry Letters. 2: 597-602. PMID 21841963 DOI: 10.1021/ml200084n  0.64
2011 Iannello A, Debbeche O, El Arabi R, Samarani S, Hamel D, Rozenberg F, Heveker N, Ahmad A. Herpes simplex virus type 1-induced FasL expression in human monocytic cells and its implications for cell death, viral replication, and immune evasion. Viral Immunology. 24: 11-26. PMID 21319975 DOI: 10.1089/vim.2010.0083  0.64
2011 Berchiche YA, Gravel S, Pelletier ME, St-Onge G, Heveker N. Different effects of the different natural CC chemokine receptor 2b ligands on beta-arrestin recruitment, Gαi signaling, and receptor internalization. Molecular Pharmacology. 79: 488-98. PMID 21088225 DOI: 10.1124/mol.110.068486  0.64
2011 Gendron K, Ferbeyre G, Heveker N, Brakier-Gingras L. The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element. Nucleic Acids Research. 39: 902-12. PMID 20935056 DOI: 10.1093/nar/gkq885  0.64
2011 Berchiche YA, Chow KY, Lagane B, Leduc M, Percherancier Y, Fujii N, Tamamura H, Bachelerie F, Heveker N. Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and Gα i activation (THe Journal of Biological Chemistry (2007) 282, (5111-5115)) Journal of Biological Chemistry. 286: 29440. DOI: 10.1074/jbc.A111.600270  0.64
2010 Gravel S, Malouf C, Boulais PE, Berchiche YA, Oishi S, Fujii N, Leduc R, Sinnett D, Heveker N. The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains. The Journal of Biological Chemistry. 285: 37939-43. PMID 20956518 DOI: 10.1074/jbc.C110.147470  0.64
2009 Rihakova L, Quiniou C, Hamdan FF, Kaul R, Brault S, Hou X, Lahaie I, Sapieha P, Hamel D, Shao Z, Gobeil F, Hardy P, Joyal JS, Nedev H, Duhamel F, ... ... Heveker N, et al. VRQ397 (CRAVKY): a novel noncompetitive V2 receptor antagonist. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 297: R1009-18. PMID 19641130 DOI: 10.1152/ajpregu.90766.2008  0.64
2009 Boulais PE, Dulude D, Cabana J, Heveker N, Escher E, Lavigne P, Leduc R. Photolabeling identifies transmembrane domain 4 of CXCR4 as a T140 binding site Biochemical Pharmacology. 78: 1382-1390. PMID 19631193 DOI: 10.1016/j.bcp.2009.07.007  0.64
2009 Rafei M, Berchiche YA, Birman E, Boivin MN, Young YK, Wu JH, Heveker N, Galipeau J. An engineered GM-CSF-CCL2 fusokine is a potent inhibitor of CCR2-driven inflammation as demonstrated in a murine model of inflammatory arthritis. Journal of Immunology (Baltimore, Md. : 1950). 183: 1759-66. PMID 19592643 DOI: 10.4049/jimmunol.0900523  0.64
2009 Leduc M, Breton B, Galés C, Le Gouill C, Bouvier M, Chemtob S, Heveker N. Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands. The Journal of Pharmacology and Experimental Therapeutics. 331: 297-307. PMID 19584306 DOI: 10.1124/jpet.109.156398  0.64
2009 Sauvé K, Lepage J, Sanchez M, Heveker N, Tremblay A. Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway. Cancer Research. 69: 5793-800. PMID 19584281 DOI: 10.1158/0008-5472.CAN-08-4924  0.64
2009 Lambert S, Bouttier M, Vassy R, Seigneuret M, Petrow-Sadowski C, Janvier S, Heveker N, Ruscetti FW, Perret G, Jones KS, Pique C. HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165. Blood. 113: 5176-85. PMID 19270265 DOI: 10.1182/blood-2008-04-150342  0.64
2009 Kalatskaya I, Berchiche YA, Gravel S, Limberg BJ, Rosenbaum JS, Heveker N. AMD3100 is a CXCR7 ligand with allosteric agonist properties. Molecular Pharmacology. 75: 1240-7. PMID 19255243 DOI: 10.1124/mol.108.053389  0.64
2008 Quiniou C, Sapieha P, Lahaie I, Hou X, Brault S, Beauchamp M, Leduc M, Rihakova L, Joyal JS, Nadeau S, Heveker N, Lubell W, Sennlaub F, Gobeil F, Miller G, et al. Development of a novel noncompetitive antagonist of IL-1 receptor. Journal of Immunology (Baltimore, Md. : 1950). 180: 6977-87. PMID 18453620  0.64
2008 Dulude D, Théberge-Julien G, Brakier-Gingras L, Heveker N. Selection of peptides interfering with a ribosomal frameshift in the human immunodeficiency virus type 1. Rna (New York, N.Y.). 14: 981-91. PMID 18367719 DOI: 10.1261/rna.887008  0.64
2008 Gendron K, Charbonneau J, Dulude D, Heveker N, Ferbeyre G, Brakier-Gingras L. The presence of the TAR RNA structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (HIV-1) by modifying the rate of translation initiation. Nucleic Acids Research. 36: 30-40. PMID 17984074 DOI: 10.1093/nar/gkm906  0.64
2007 Desjardins SF, Berchiche YA, Haddad E, Heveker N. [Multiple talents of the chemokine receptor-CXCR4]. MéDecine Sciences : M/S. 23: 980-4. PMID 18021711 DOI: 10.1051/medsci/20072311980  0.64
2007 Berchiche YA, Chow KY, Lagane B, Leduc M, Percherancier Y, Fujii N, Tamamura H, Bachelerie F, Heveker N. Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation. The Journal of Biological Chemistry. 282: 5111-5. PMID 17197449 DOI: 10.1074/jbc.C600270200  0.64
2007 Bouvier M, Heveker N, Jockers R, Marullo S, Milligan G. BRET analysis of GPCR oligomerization: newer does not mean better. Nature Methods. 4: 3-4; author reply 4. PMID 17195017 DOI: 10.1038/nmeth0107-3  0.64
2006 Gobeil F, Fortier A, Zhu T, Bossolasco M, Leduc M, Grandbois M, Heveker N, Bkaily G, Chemtob S, Barbaz D. G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm. Canadian Journal of Physiology and Pharmacology. 84: 287-97. PMID 16902576 DOI: 10.1139/y05-127  0.64
2006 Ghez D, Lepelletier Y, Lambert S, Fourneau JM, Blot V, Janvier S, Arnulf B, van Endert PM, Heveker N, Pique C, Hermine O. Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry. Journal of Virology. 80: 6844-54. PMID 16809290 DOI: 10.1128/JVI.02719-05  0.64
2006 Gobeil F, Zhu T, Brault S, Geha A, Vazquez-Tello A, Fortier A, Barbaz D, Checchin D, Hou X, Nader M, Bkaily G, Gratton JP, Heveker N, Ribeiro-da-Silva A, Peri K, et al. Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1. The Journal of Biological Chemistry. 281: 16058-67. PMID 16574649 DOI: 10.1074/jbc.M602219200  0.64
2006 Zhu T, Sennlaub F, Beauchamp MH, Fan L, Joyal JS, Checchin D, Nim S, Lachapelle P, Sirinyan M, Hou X, Bossolasco M, Rivard GE, Heveker N, Chemtob S. Proangiogenic effects of protease-activated receptor 2 are tumor necrosis factor-alpha and consecutively Tie2 dependent. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 744-50. PMID 16439712 DOI: 10.1161/01.ATV.0000205591.88522.d4  0.64
2006 Dulude D, Berchiche YA, Gendron K, Brakier-Gingras L, Heveker N. Decreasing the frameshift efficiency translates into an equivalent reduction of the replication of the human immunodeficiency virus type 1. Virology. 345: 127-36. PMID 16256163 DOI: 10.1016/j.virol.2005.08.048  0.64
2005 Janvier S, Heveker N. [Mystery upon the origin for the selection of AIDS-protective CCR5Delta32]. MéDecine Sciences : M/S. 21: 577-9. PMID 15985194 DOI: 10.1051/medsci/2005216-7577  0.64
2005 Fan L, Yotov WV, Zhu T, Esmailzadeh L, Joyal JS, Sennlaub F, Heveker N, Chemtob S, Rivard GE. Tissue factor enhances protease-activated receptor-2-mediated factor VIIa cell proliferative properties Journal of Thrombosis and Haemostasis. 3: 1056-1063. PMID 15869604 DOI: 10.1111/j.1538-7836.2005.01250.x  0.64
2005 Percherancier Y, Berchiche YA, Slight I, Volkmer-Engert R, Tamamura H, Fujii N, Bouvier M, Heveker N. Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers. The Journal of Biological Chemistry. 280: 9895-903. PMID 15632118 DOI: 10.1074/jbc.M411151200  0.64
2004 Hartley O, Gaertner H, Wilken J, Thompson D, Fish R, Ramos A, Pastore C, Dufour B, Cerini F, Melotti A, Heveker N, Picard L, Alizon M, Mosier D, Kent S, et al. Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors Proceedings of the National Academy of Sciences of the United States of America. 101: 16460-16465. PMID 15545608 DOI: 10.1073/pnas.0404802101  0.64
2002 Münch J, Ständker L, Pöhlmann S, Baribaud F, Papkalla A, Rosorius O, Stauber R, Sass G, Heveker N, Adermann K, Escher S, Klüver E, Doms RW, Forssmann WG, Kirchhoff F. Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages. Antimicrobial Agents and Chemotherapy. 46: 982-90. PMID 11897579 DOI: 10.1128/AAC.46.4.982-990.2002  0.64
2001 Baribaud F, Edwards TG, Sharron M, Brelot A, Heveker N, Price K, Mortari F, Alizon M, Tsang M, Doms RW. Antigenically distinct conformations of CXCR4. Journal of Virology. 75: 8957-67. PMID 11533159 DOI: 10.1128/JVI.75.19.8957-8967.2001  0.64
2001 Heveker N, Tissot M, Thuret A, Schneider-Mergener J, Alizon M, Roch M, Marullo S. Pharmacological properties of peptides derived from stromal cell-derived factor 1: study on human polymorphonuclear cells. Molecular Pharmacology. 59: 1418-25. PMID 11353801  0.64
2001 Trouplin V, Salvatori F, Cappello F, Obry V, Brelot A, Heveker N, Alizon M, Scarlatti G, Clavel F, Mammano F. Determination of coreceptor usage of human immunodeficiency virus type 1 from patient plasma samples by using a recombinant phenotypic assay Journal of Virology. 75: 251-259. PMID 11119595 DOI: 10.1128/JVI.75.1.251-259.2001  0.64
2000 Montes M, Tagieva NE, Heveker N, Nahmias C, Baleux F, Trautmann A. SDF-1-induced activation of ERK enhances HIV-1 expression European Cytokine Network. 11: 470-477. PMID 11022134  0.64
2000 Brelot A, Heveker N, Montes M, Alizon M. Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor Journal of Biological Chemistry. 275: 23736-23744. PMID 10825158 DOI: 10.1074/jbc.M000776200  0.64
2000 Liu LX, Heveker N, Fackler OT, Arold S, Le Gall S, Janvier K, Peterlin BM, Dumas C, Schwartz O, Benichou S, Benarous R. Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions. Journal of Virology. 74: 5310-9. PMID 10799608 DOI: 10.1128/JVI.74.11.5310-5319.2000  0.64
1999 Iwaki M, Kamachi K, Heveker N, Konda T. Suppression of platelet aggregation by Bordetella pertussis adenylate cyclase toxin Infection and Immunity. 67: 2763-2768. PMID 10338478  0.64
1999 Richardson J, Pancino G, Merat R, Leste-Lasserre T, Moraillon A, Schneider-Mergener J, Alizon M, Sonigo P, Heveker N. Shared usage of the chemokine receptor CXCR4 by primary and laboratory- adapted strains of feline immunodeficiency virus Journal of Virology. 73: 3661-3671. PMID 10196258  0.64
1999 Brelot A, Heveker N, Adema K, Hosie MJ, Willett B, Alizon M. Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses. Journal of Virology. 73: 2576-86. PMID 10074102  0.64
1998 Reeves JD, Heveker N, Brelot A, Alizon M, Clapham PR, Picard L. The second extracellular loop of CXCR4 is involved in CD4-independent entry of human immunodeficiency virus type 2. The Journal of General Virology. 79: 1793-9. PMID 9680144 DOI: 10.1099/0022-1317-79-7-1793  0.64
1998 Willett BJ, Adema K, Heveker N, Brelot A, Picard L, Alizon M, Turner JD, Hoxie JA, Peiper S, Neil JC, Hosie MJ. The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus. Journal of Virology. 72: 6475-81. PMID 9658090  0.64
1998 Labrosse B, Brelot A, Heveker N, Sol N, Schols D, De Clercq E, Alizon M. Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100 Journal of Virology. 72: 6381-6388. PMID 9658078  0.64
1998 Heveker N, Montes M, Germeroth L, Amara A, Trautmann A, Alizon M, Schneider-Mergener J. Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides Current Biology. 8: 369-376. PMID 9545196  0.64
1997 Pleskoff O, Tréboute C, Brelot A, Heveker N, Seman M, Alizon M. Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry Science. 276: 1874-1878. PMID 9188536 DOI: 10.1126/science.276.5320.1874  0.64
1997 Brelot A, Heveker N, Pleskoff O, Sol N, Alizon M. Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity Journal of Virology. 71: 4744-4751. PMID 9151868  0.64
1997 Heveker N, Ladant D. Characterization of mutant Bordetella pertussis adenylate cyclase toxins with reduced affinity for calmodulin Implications for the mechanism of toxin entry into target cells European Journal of Biochemistry. 243: 643-649. PMID 9057827  0.64
1994 Heveker N, Bonnaffé D, Ullmann A. Chemical fatty acylation confers hemolytic and toxic activities to adenylate cyclase protoxin of Bordetella pertussis. The Journal of Biological Chemistry. 269: 32844-7. PMID 7806509  0.64
1994 Heveker N, Kiessig ST, Glaser R, Hungerer KD, Von Baehr R. Characterization of neutralizing monoclonal antibodies directed against Staphylococcus aureus alpha-toxin Hybridoma. 13: 263-270. PMID 7528719  0.64
1994 Heveker N, Hansen A, Hungerer KD, von Baehr R, Glaser RW. A human monoclonal antibody with the capacity to neutralize Staphylococcus aureus alpha-toxin Human Antibodies. 5: 18-24. DOI: 10.3233/HAB-1994-51-203  0.64
1994 Heveker N. 856/90, 858/883, 858/22, 858/255, 926/350 anti-alpha toxin Hybridoma. 13: 332.  0.64
1992 Rossi G, Heveker N, Thiele B, Gelderblom H, Steinbach F. Development of a Langerhans cell phenotype from peripheral blood monocytes Immunology Letters. 31: 189-197. PMID 1371267 DOI: 10.1016/0165-2478(92)90145-E  0.64
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