Jurgen Sygusch - Publications

Affiliations: 
Faculte de medecine Université de Montréal, Montréal, Canada 
Area:
Molecular Biology, Biochemistry

81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Belardinelli JM, Yazidi A, Yang L, Fabre L, Li W, Jacques B, Angala SK, Rouiller I, Zgurskaya HI, Sygusch J, Jackson M. Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis. Acs Infectious Diseases. 2: 702-713. PMID 27737557 DOI: 10.1021/acsinfecdis.6b00095  1
2016 Wahba H, Lecoq L, Stevenson MJ, Mansour A, Cappadocia L, Lafrance-Vanasse J, Wilkinson KJ, Sygusch J, Wilcox DE, Omichinski JG. Structural and biochemical characterization of a copper-binding mutant of the organomercurial lyase MerB: Insight into the key role of the active site aspartic acid in both Hg-carbon bond cleavage and metal-binding specificity. Biochemistry. PMID 26820485 DOI: 10.1021/acs.biochem.5b01298  1
2015 Tanner JE, Coinçon M, Leblond V, Hu J, Fang JM, Sygusch J, Alfieri C. Peptides designed to spatially depict the Epstein-Barr virus major virion glycoprotein gp350 neutralization epitope elicit antibodies that block virus-neutralizing antibody 72A1 interaction with the native gp350 molecule. Journal of Virology. 89: 4932-41. PMID 25694592 DOI: 10.1128/JVI.03269-14  1
2013 Cappadocia L, Parent JS, Sygusch J, Brisson N. A family portrait: structural comparison of the Whirly proteins from Arabidopsis thaliana and Solanum tuberosum. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 69: 1207-11. PMID 24192350 DOI: 10.1107/S1744309113028698  1
2012 Smith MA, Coinçon M, Paschos A, Jolicoeur B, Lavallée P, Sygusch J, Baron C. Identification of the binding site of Brucella VirB8 interaction inhibitors. Chemistry & Biology. 19: 1041-8. PMID 22921071 DOI: 10.1016/j.chembiol.2012.07.007  1
2012 Coincon M, Wang W, Sygusch J, Seah SY. Crystal structure of reaction intermediates in pyruvate class II aldolase: substrate cleavage, enolate stabilization, and substrate specificity. The Journal of Biological Chemistry. 287: 36208-21. PMID 22908224 DOI: 10.1074/jbc.M112.400705  1
2012 Cappadocia L, Parent JS, Zampini E, Lepage E, Sygusch J, Brisson N. A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage. Nucleic Acids Research. 40: 258-69. PMID 21911368 DOI: 10.1093/nar/gkr740  1
2011 Mabiala-Bassiloua CG, Arthus-Cartier G, Hannaert V, Thérisod H, Sygusch J, Thérisod M. Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases. Acs Medicinal Chemistry Letters. 2: 804-8. PMID 24900268 DOI: 10.1021/ml200129s  1
2011 de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, et al. Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. The Journal of Biological Chemistry. 286: 40219-31. PMID 21949126 DOI: 10.1074/jbc.M111.259440  1
2010 Daher R, Coinçon M, Fonvielle M, Gest PM, Guerin ME, Jackson M, Sygusch J, Therisod M. Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases. Journal of Medicinal Chemistry. 53: 7836-42. PMID 20929256 DOI: 10.1021/jm1009814  1
2010 Cappadocia L, Maréchal A, Parent JS, Lepage E, Sygusch J, Brisson N. Crystal structures of DNA-Whirly complexes and their role in Arabidopsis organelle genome repair. The Plant Cell. 22: 1849-67. PMID 20551348 DOI: 10.1105/tpc.109.071399  1
2010 Park H, Rangarajan ES, Sygusch J, Izard T. Dramatic improvement of crystal quality for low-temperature-grown rabbit muscle aldolase. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 595-600. PMID 20445268 DOI: 10.1107/S1744309110011875  1
2010 LowKam C, Liotard B, Sygusch J. Structure of a class I tagatose-1,6-bisphosphate aldolase: investigation into an apparent loss of stereospecificity. The Journal of Biological Chemistry. 285: 21143-52. PMID 20427286 DOI: 10.1074/jbc.M109.080358  1
2010 Rangarajan ES, Park H, Fortin E, Sygusch J, Izard T. Mechanism of aldolase control of sorting nexin 9 function in endocytosis. The Journal of Biological Chemistry. 285: 11983-90. PMID 20129922 DOI: 10.1074/jbc.M109.092049  1
2009 Starnes GL, Coincon M, Sygusch J, Sibley LD. Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells. Cell Host & Microbe. 5: 353-64. PMID 19380114 DOI: 10.1016/j.chom.2009.03.005  1
2009 St-Jean M, Blonski C, Sygusch J. Charge stabilization and entropy reduction of central lysine residues in fructose-bisphosphate aldolase. Biochemistry. 48: 4528-37. PMID 19354220 DOI: 10.1021/bi8021558  1
2009 Lafrance-Vanasse J, Lefebvre M, Di Lello P, Sygusch J, Omichinski JG. Crystal structures of the organomercurial lyase MerB in its free and mercury-bound forms: insights into the mechanism of methylmercury degradation. The Journal of Biological Chemistry. 284: 938-44. PMID 19004822 DOI: 10.1074/jbc.M807143200  1
2008 Cappadocia L, Sygusch J, Brisson N. Purification, crystallization and preliminary X-ray diffraction analysis of the Whirly domain of StWhy2 in complex with single-stranded DNA Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 64: 1056-1059. PMID 18997341 DOI: 10.1107/S1744309108032399  1
2008 Fonvielle M, Coinçon M, Daher R, Desbenoit N, Kosieradzka K, Barilone N, Gicquel B, Sygusch J, Jackson M, Therisod M. Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 8521-9. PMID 18688832 DOI: 10.1002/chem.200800857  1
2008 Mabiala-Bassiloua CG, Zwolinska M, Therisod H, Sygusch J, Therisod M. Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases. Bioorganic & Medicinal Chemistry Letters. 18: 1735-7. PMID 18261903 DOI: 10.1016/j.bmcl.2008.01.076  1
2007 St-Jean M, Sygusch J. Stereospecific proton transfer by a mobile catalyst in mammalian fructose-1,6-bisphosphate aldolase. The Journal of Biological Chemistry. 282: 31028-37. PMID 17728250 DOI: 10.1074/jbc.M704968200  1
2007 Lafrance-Vanasse J, Sygusch J. Carboxy-terminus recruitment induced by substrate binding in eukaryotic fructose bis-phosphate aldolases. Biochemistry. 46: 9533-40. PMID 17661446 DOI: 10.1021/bi700615r  1
2007 St-Jean M, Izard T, Sygusch J. A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein. The Journal of Biological Chemistry. 282: 14309-15. PMID 17329259 DOI: 10.1074/jbc.M611505200  1
2006 Dax C, Duffieux F, Chabot N, Coincon M, Sygusch J, Michels PA, Blonski C. Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei. Journal of Medicinal Chemistry. 49: 1499-502. PMID 16509566 DOI: 10.1021/jm050237b  1
2005 St-Jean M, Lafrance-Vanasse J, Liotard B, Sygusch J. High resolution reaction intermediates of rabbit muscle fructose-1,6-bisphosphate aldolase: substrate cleavage and induced fit. The Journal of Biological Chemistry. 280: 27262-70. PMID 15870069 DOI: 10.1074/jbc.M502413200  1
2005 Dax C, Coinçon M, Sygusch J, Blonski C. Hydroxynaphthaldehyde phosphate derivatives as potent covalent Schiff base inhibitors of fructose-1,6-bisphosphate aldolase. Biochemistry. 44: 5430-43. PMID 15807536 DOI: 10.1021/bi0477992  1
2004 Liotard B, Sygusch J. Purification, crystallization and preliminary X-ray analysis of native and selenomethionine class I tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes. Acta Crystallographica. Section D, Biological Crystallography. 60: 528-30. PMID 14993682 DOI: 10.1107/S0907444903028427  1
2004 Izard T, Sygusch J. Induced fit movements and metal cofactor selectivity of class II aldolases: structure of Thermus aquaticus fructose-1,6-bisphosphate aldolase. The Journal of Biological Chemistry. 279: 11825-33. PMID 14699122 DOI: 10.1074/jbc.M311375200  1
2003 Azéma L, Lakhdar-Ghazal F, Sygusch J, Blonski C. Characterization of proton abstraction steps in enzymatic reactions by Fourier transform infrared spectroscopy Analytical Biochemistry. 318: 142-145. PMID 12782042 DOI: 10.1016/S0003-2697(03)00165-9  1
2003 Kawaji M, Gamache O, Hwang DH, Ichikawa N, Viola JP, Sygusch J. Investigation of Marangoni and natural convection during protein crystal growth Journal of Crystal Growth. 258: 420-430. DOI: 10.1016/S0022-0248(03)01570-7  1
2002 Desveaux D, Allard J, Brisson N, Sygusch J. A new family of plant transcription factors displays a novel ssDNA-binding surface Nature Structural Biology. 9: 512-517. PMID 12080340 DOI: 10.1038/nsb814  1
2002 Desveaux D, Allard J, Brisson N, Sygusch J. Crystallization and preliminary X-ray crystallographic analysis of p24, a component of the potato nuclear factor PBF-2 Acta Crystallographica Section D: Biological Crystallography. 58: 296-298. PMID 11807255 DOI: 10.1107/S0907444901018741  1
2002 Maurady A, Zdanov A, de Moissac D, Beaudry D, Sygusch J. A conserved glutamate residue exhibits multifunctional catalytic roles in D-fructose-1,6-bisphosphate aldolases. The Journal of Biological Chemistry. 277: 9474-83. PMID 11779856 DOI: 10.1074/jbc.M107600200  1
2001 Allard J, Grochulski P, Sygusch J. Covalent intermediate trapped in 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase structure at 1.95-Å resolution Proceedings of the National Academy of Sciences of the United States of America. 98: 3679-3684. PMID 11274385 DOI: 10.1073/pnas.071380898  1
2001 Sauvé V, Sygusch J. Molecular cloning, expression, purification, and characterization of fructose-1,6-bisphosphate aldolase from Thermus aquaticus Protein Expression and Purification. 21: 293-302. PMID 11237691 DOI: 10.1006/prep.2000.1380  1
2001 Sauvé V, Sygusch J. Crystallization and preliminary x-ray analysis of native and selenomethionine fructose-1,6-bisphosphate aldolase from Thermus aquaticus Acta Crystallographica Section D: Biological Crystallography. 57: 310-313. PMID 11173490 DOI: 10.1107/S0907444900019727  1
2001 Yoon TS, Tétreault S, Bosshard HE, Sweet RM, Sygusch J. Mosaic spread analysis of Canadian advanced protein crystallization experiment on the Russian space station, Mir Journal of Crystal Growth. 232: 520-535. DOI: 10.1016/S0022-0248(01)01165-4  1
2000 Rellos P, Sygusch J, Cox TM. Expression, purification, and characterization of natural mutants of human aldolase B. Role of quaternary structure in catalysis Journal of Biological Chemistry. 275: 1145-1151. PMID 10625657 DOI: 10.1074/jbc.275.2.1145  1
1999 Rellos P, Ali M, Vidailhet M, Sygusch J, Cox TM. Alteration of substrate specificity by a naturally-occurring aldolase B mutation (Ala337→Val) in fructose intolerance Biochemical Journal. 340: 321-327. PMID 10229688 DOI: 10.1042/0264-6021:3400321  1
1999 Todd P, F. Doyle J, Carter P, Wachtel H, Deuser MS, Vellinger JC, Cassanto JM, Alvarado U, Sygusch J, Kent TB. Magnetic space shuttle experiments Journal of Magnetism and Magnetic Materials. 194: 96-101. DOI: 10.1016/S0304-8853(98)00550-2  1
1998 Ethier N, Talbot G, Sygusch J. Gene cloning, DNA sequencing, and expression of thermostable β- mannanase from Bacillus stearothermophilus Applied and Environmental Microbiology. 64: 4428-4432. PMID 9797302  1
1997 Sygusch J, Beaudry D. Allosteric communication in mammalian muscle aldolase Biochemical Journal. 327: 717-720. PMID 9581547  1
1997 Blonski C, De Moissac D, Périé J, Sygusch J. Inhibition of rabbit muscle aldolase by phosphorylated aromatic compounds Biochemical Journal. 323: 71-77. PMID 9173904  1
1997 Sygusch J, Beaudry D. Subunit interaction in mammalian aldolases Biochemical Journal. 323: 671-676. PMID 9169599  1
1997 Blom NS, Sygusch J. High resolution fast quantitative docking using Fourier domain correlation techniques Proteins: Structure, Function and Genetics. 27: 493-506. PMID 9141130 DOI: 10.1002/(SICI)1097-0134(199704)27:4<493::AID-PROT3>3.0.CO;2-C  1
1997 Biota N, Sygusch J. Product binding and role of the C-terminal region in class I D-fructose 1,6-bisphosphate aldolase Nature Structural Biology. 4: 36-39. PMID 8989320 DOI: 10.1038/nsb0197-36  1
1996 Sygusch J, Coulombe R, Cassanto JM, Sportiello MG, Todd P. Protein crystallization in low gravity by step gradient diffusion method. Journal of Crystal Growth. 162: 167-72. PMID 11542285  1
1996 De Montigny C, Sygusch J. Functional characterization of an extreme thermophilic class II fructose-1,6-bisphosphate aldolase European Journal of Biochemistry. 241: 243-248. PMID 8898912  1
1996 Blom NS, Tétreault S, Coulombe R, Sygusch J. Novel active site in Escherichia coli fructose 1,6-bisphosphate aldolase Nature Structural Biology. 3: 856-862. PMID 8836102 DOI: 10.1038/nsb1096-856  1
1993 Berthiaume L, Tolan DR, Sygusch J. Differential usage of the carboxyl-terminal region among aldolase isozymes Journal of Biological Chemistry. 268: 10826-10835. PMID 8496148  1
1992 Palin MF, Berthiaume L, Lehoux JG, Waterman MR, Sygusch J. Direct expression of mature bovine adrenodoxin in Escherichia coli Archives of Biochemistry and Biophysics. 295: 126-131. PMID 1575507 DOI: 10.1016/0003-9861(92)90497-K  1
1991 Berthiaume L, Loisel TP, Sygusch J. Carboxyl terminus region modulates catalytic activity of recombinant maize aldolase Journal of Biological Chemistry. 266: 17099-17105. PMID 1894606  1
1990 Sygusch J, Beaudry D, Allaire M. Inactivation of mammalian fructose diphosphate aldolases by COOH terminus autophosphorylation Archives of Biochemistry and Biophysics. 283: 227-233. PMID 2275541 DOI: 10.1016/0003-9861(90)90636-D  1
1990 Talbot G, Sygusch J. Purification and characterization of thermostable β-mannanase and α-galactosidase from Bacillus stearothermophilus Applied and Environmental Microbiology. 56: 3505-3510. PMID 2176449  1
1990 Pelletier A, Lemire I, Sygusch J, Chornet E, Overend RP. Chitin/chitosan transformation by thermo-mechano-chemical treatment including characterization by enzymatic depolymerization(*) Biotechnology and Bioengineering. 36: 310-315. DOI: 10.1002/bit.260360313  1
1990 Pelletier A, Sygusch J. Purification and characterization of three chitosanase activities from Bacillus megaterium P1 Applied and Environmental Microbiology. 56: 844-848.  1
1989 Berthiaume L, Beaudry D, Lazure C, Tolan DR, Sygusch J. Recombinant anaerobic maize aldolase: Overexpression, characterization, and metabolic implications Archives of Biochemistry and Biophysics. 272: 281-289. PMID 2751305 DOI: 10.1016/0003-9861(89)90221-X  1
1988 Sygusch J, Allaire M. Sequential radiation damage in protein crystallography Acta Crystallographica Section a: Foundations of Crystallography. 44. PMID 2978720 DOI: 10.1107/S0108767388001394  1
1987 Sygusch J, Beaudry D, Allaire M. Molecular architecture of rabbit skeletal muscle aldolase at 2.7-A resolution Proceedings of the National Academy of Sciences of the United States of America. 84: 7846-7850. PMID 3479768  1
1985 Sygusch J. Least-squares MIR calculations: Minimum variance Fourier coefficient (MVFC) refinement Methods in Enzymology. 115: 15-22. PMID 4079784 DOI: 10.1016/0076-6879(85)15004-4  1
1985 Sygusch J, Beaudry D. Preliminary crystallographic investigation of rabbit liver aldolase Journal of Molecular Biology. 186: 215-217. PMID 4078900 DOI: 10.1016/0022-2836(85)90274-8  1
1985 Sygusch J, Boulet H, Beaudry D. Structure of rabbit muscle aldolase at low resolution Journal of Biological Chemistry. 260: 15286-15290. PMID 4066671  1
1985 Sygusch J, Beaudry D. Phosphate ion inactivation of rabbit skeletal muscle aldolase in the crystalline state Biochemical and Biophysical Research Communications. 128: 417-423. PMID 3985979 DOI: 10.1016/0006-291X(85)91695-X  1
1985 Fletterick RJ, Sygusch J. Measuring X-ray diffraction data from large proteins with X-ray diffractometry Methods in Enzymology. 386-397.  1
1984 Sygusch J, Lehoux L, Beaudry D. Extreme X-ray sensitive modification of type I aldolases by blue dye ligand chromatography Biochemical and Biophysical Research Communications. 123: 1069-1075. PMID 6487321 DOI: 10.1016/S0006-291X(84)80242-9  1
1984 Sygusch J, Beaudry D. Catalytic activity of rabbit skeletal muscle aldolase in the crystalline state Journal of Biological Chemistry. 259: 10222-10227. PMID 6469960  1
1983 Alden RA, Bricogne G, Freer ST, Hall SR, Hendrickson WA, Machin PA, Munn RJ, Olson AJ, Reeke GN, Stewart JM, Sygusch J, TenEyck LF, Watenpaugh KD. Cooperative programming in crystallography Computers and Chemistry. 7: 137-148. DOI: 10.1016/0097-8485(83)85005-0  1
1982 Amzel LM, Narayanan P, Pedersen PL, Sygusch J. The three-dimensional structure of F1-ATPases Annals of the New York Academy of Sciences. 21-27. PMID 6220637 DOI: 10.1111/j.1749-6632.1982.tb25729.x  1
1978 Kasvinsky PJ, Madsen NB, Sygusch J, Fletterick RJ. The regulation of glycogen phosphorylase alpha by nucleotide derivatives. Kinetic and x-ray crystallographic studies. The Journal of Biological Chemistry. 253: 3343-51. PMID 641070  1
1978 Kasvinsky PJ, Madsen NB, Fletterick RJ, Sygusch J. X-ray crystallographic and kinetic studies of oligosaccharide binding to phosphorylase. The Journal of Biological Chemistry. 253: 1290-6. PMID 624732  1
1977 Li EC, Fletterick RJ, Sygusch J, Madsen NB. An essential arginine residue in the active-site pocket of glycogen phosporylase. Canadian Journal of Biochemistry. 55: 465-73. PMID 870152  1
1977 Sygusch J, Madsen NB, Kasvinsky PJ, Fletterick RJ. Location of pyridoxal phosphate in glycogen phosphorylase a. Proceedings of the National Academy of Sciences of the United States of America. 74: 4757-61. PMID 270710  1
1976 Fletterick RJ, Sygusch J, Murray N, Madsen NB. Low-resolution structure of the glycogen phosphorylase alpha monomer and comparison with phosphorylase beta. Journal of Molecular Biology. 103: 1-13. PMID 957422 DOI: 10.1016/0010-7824(76)90016-0  1
1976 Fletterick RJ, Sygusch J, Semple H, Madsen NB. Structure of glycogen phosphorylase a at 3.0 A resolution and its ligand binding sites at 6 A. The Journal of Biological Chemistry. 251: 6142-6. PMID 184094  1
1976 Fletterick RJ, Sygusch J, Murray N, Madsen NB, Johnson LN. Low-resolution structure of the glycogen phosphorylase a monomer and comparison with phosphorylase b Journal of Molecular Biology. 103: 1-13. DOI: 10.1016/0022-2836(76)90048-6  1
1975 Sygusch J, Brisse F, Hanessian S. Crystal and molecular structure of naphthyridinomycin ... etc Tetrahedron Letters. 16: 170.  1
1975 Sygusch J, Brisse F, Hanessian S. Crystal and molecular structure of naphthyridinomycin. A broad spectrum antibiotic Tetrahedron Letters. 16: 170.  1
1975 Cantara JL, Sygusch J, Cyr J. THEORETICAL STUDIES OF CONFORMATION - 1. GEOMETRICAL OPTIMIZATION OF SOME HYDRATED ALDOPYRANOSES . 59-72.  1
1974 Sygusch J, Brisse F, Hannessian S. The Crystal and Molecular Structure of Cytosamine Triacetate Acta Crystallographica Section B. 30: 40-47. DOI: 10.1111/j.1600-5740.1974.tb00008.x  1
1974 Sygusch J, Brisse F, Hanessian S, Kluepfel D. The molecular structure of naphthyridinomycin- a broad spectrum antibiotic Tetrahedron Letters. 15: 4021-4023. DOI: 10.1016/S0040-4039(01)92073-8  1
1974 Sygusch J. On the application of complete orthonormal atomic basis sets to x-rays diffracted by a thermally excited molecule Chemical Physics. 5: 142-148. DOI: 10.1016/0301-0104(74)80014-5  1
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