Gerold Schmitt-Ulms - Publications

Laboratory Medicine and Pathobiology University of Toronto, Toronto, ON, Canada 
Genetics, Cell Biology, Neuroscience Biology, Bioinformatics Biology, Biochemistry

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Solarski M, Williams D, Mehrabian M, Wang H, Wille H, Schmitt-Ulms G. The human brain somatostatin interactome: SST binds selectively to P-type family ATPases. Plos One. 14: e0217392. PMID 31136617 DOI: 10.1371/journal.pone.0217392  0.52
2019 Bourkas MEC, Arshad H, Al-Azzawi ZAM, Halgas O, Shikiya RA, Mehrabian M, Schmitt-Ulms G, Bartz JC, Watts JC. Engineering a murine cell line for the stable propagation of hamster prions. The Journal of Biological Chemistry. PMID 30705093 DOI: 10.1074/jbc.RA118.007135  0.52
2018 Ghodrati F, Mehrabian M, Williams D, Halgas O, Bourkas MEC, Watts JC, Pai EF, Schmitt-Ulms G. The prion protein is embedded in a molecular environment that modulates transforming growth factor β and integrin signaling. Scientific Reports. 8: 8654. PMID 29872131 DOI: 10.1038/s41598-018-26685-x  0.52
2017 Brethour D, Mehrabian M, Williams D, Wang X, Ghodrati F, Ehsani S, Rubie EA, Woodgett JR, Sevalle J, Xi Z, Rogaeva E, Schmitt-Ulms G. A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Scientific Reports. 7: 40313. PMID 28098160 DOI: 10.1038/srep40313  0.52
2016 Mehrabian M, Hildebrandt H, Schmitt-Ulms G. NCAM1 Polysialylation: The Prion Protein's Elusive Reason for Being? Asn Neuro. 8. PMID 27879349 DOI: 10.1177/1759091416679074  0.52
2016 Rogaeva E, Schmitt-Ulms G. Does BDNF Val66Met contribute to preclinical Alzheimer's disease? Brain : a Journal of Neurology. 139: 2586-2589. PMID 27671028 DOI: 10.1093/brain/aww201  0.72
2016 Mehrabian M, Brethour D, Williams D, Wang H, Arnould H, Schneider B, Schmitt-Ulms G. Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue. Plos One. 11: e0156779. PMID 27327609 DOI: 10.1371/journal.pone.0156779  0.72
2015 Murakami T, Qamar S, Lin JQ, Schierle GS, Rees E, Miyashita A, Costa AR, Dodd RB, Chan FT, Michel CH, Kronenberg-Versteeg D, Li Y, Yang SP, Wakutani Y, Meadows W, ... ... Schmitt-Ulms G, et al. ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function. Neuron. PMID 26526393 DOI: 10.1016/j.neuron.2015.10.030  0.72
2015 Mehrabian M, Brethour D, Wang H, Xi Z, Rogaeva E, Schmitt-Ulms G. The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis. Plos One. 10: e0133741. PMID 26288071 DOI: 10.1371/journal.pone.0133741  0.52
2015 Gunawardana CG, Mehrabian M, Wang X, Mueller I, Lubambo IB, Jonkman JE, Wang H, Schmitt-Ulms G. The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome. Molecular & Cellular Proteomics : McP. 14: 3000-14. PMID 26269332 DOI: 10.1074/mcp.M115.050724  0.72
2015 Bohm C, Chen F, Sevalle J, Qamar S, Dodd R, Li Y, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways. Molecular and Cellular Neurosciences. 66: 3-11. PMID 25748120 DOI: 10.1016/j.mcn.2015.02.016  0.72
2015 Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, ... ... Schmitt-Ulms G, et al. Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation. Embo Molecular Medicine. 7: 339-56. PMID 25661904 DOI: 10.15252/emmm.201404588  0.72
2015 Mehrabian M, Brethour D, Wang H, Xi Z, Rogaeva E, Schmitt-Ulms G. The prion protein controls polysialylation of neural cell adhesion molecule 1 during cellular morphogenesis Plos One. 10. DOI: 10.1371/journal.pone.0133741  0.72
2014 Li Y, Bohm C, Dodd R, Chen F, Qamar S, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Structural biology of presenilin 1 complexes. Molecular Neurodegeneration. 9: 59. PMID 25523933 DOI: 10.1186/1750-1326-9-59  0.72
2014 Mehrabian M, Brethour D, MacIsaac S, Kim JK, Gunawardana CG, Wang H, Schmitt-Ulms G. CRISPR-Cas9-based knockout of the prion protein and its effect on the proteome. Plos One. 9: e114594. PMID 25490046 DOI: 10.1371/journal.pone.0114594  0.72
2014 Mehrabian M, Ehsani S, Schmitt-Ulms G. An emerging role of the cellular prion protein as a modulator of a morphogenetic program underlying epithelial-to-mesenchymal transition. Frontiers in Cell and Developmental Biology. 2: 53. PMID 25453033 DOI: 10.3389/fcell.2014.00053  0.52
2014 Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D. Endoproteolytic processing of the mammalian prion glycoprotein family. The Febs Journal. 281: 862-76. PMID 24286250 DOI: 10.1111/febs.12654  0.72
2014 Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, ... ... Schmitt-Ulms G, et al. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (London, England : 1993). 22: 125-35. PMID 24210759 DOI: 10.1016/j.str.2013.09.018  0.72
2013 Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D. The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. The Journal of Biological Chemistry. 288: 37241-55. PMID 24225951 DOI: 10.1074/jbc.M113.488650  0.72
2013 Pocanschi CL, Ehsani S, Mehrabian M, Wille H, Reginold W, Trimble WS, Wang H, Yee A, Arrowsmith CH, Bozóky Z, Kay LE, Forman-Kay JD, Rini JM, Schmitt-Ulms G. The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer. Plos One. 8: e72446. PMID 24039764 DOI: 10.1371/journal.pone.0072446  0.72
2013 Wang H, Ren CH, Gunawardana CG, Schmitt-Ulms G. Overcoming barriers and thresholds - signaling of oligomeric Aβ through the prion protein to Fyn. Molecular Neurodegeneration. 8: 24. PMID 23856335 DOI: 10.1186/1750-1326-8-24  0.72
2013 Jeon AH, Böhm C, Chen F, Huo H, Ruan X, Ren CH, Ho K, Qamar S, Mathews PM, Fraser PE, Mount HT, St George-Hyslop P, Schmitt-Ulms G. Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. The Journal of Biological Chemistry. 288: 15352-66. PMID 23589300 DOI: 10.1074/jbc.M112.441840  0.72
2012 Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, Ren H, Wang H, So K, Sato C, Mehrabian M, Strome R, Trimble WS, Hazrati LN, Rogaeva E, Westaway D, ... ... Schmitt-Ulms G, et al. LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation. Journal of Molecular Biology. 422: 556-74. PMID 22687393 DOI: 10.1016/j.jmb.2012.06.003  0.72
2012 Lu SH, Jeon AH, Schmitt-Ulms G, Qamar S, Dodd R, McDonald B, Li Y, Meadows W, Cox K, Bohm C, Chen F, Fraser P, George-Hyslop PS. Vigilin interacts with signal peptide peptidase. Proteome Science. 10: 33. PMID 22607704 DOI: 10.1186/1477-5956-10-33  0.72
2012 Ehsani S, Mehrabian M, Pocanschi CL, Schmitt-Ulms G. The ZIP-prion connection. Prion. 6: 317-21. PMID 22575750 DOI: 10.4161/pri.20196  0.72
2012 Harbi D, Parthiban M, Gendoo DM, Ehsani S, Kumar M, Schmitt-Ulms G, Sowdhamini R, Harrison PM. PrionHome: a database of prions and other sequences relevant to prion phenomena. Plos One. 7: e31785. PMID 22363733 DOI: 10.1371/journal.pone.0031785  0.72
2012 Jeon AH, Schmitt-Ulms G. Time-controlled transcardiac perfusion crosslinking for in vivo interactome studies. Methods in Molecular Biology (Clifton, N.J.). 803: 231-46. PMID 22065229 DOI: 10.1007/978-1-61779-364-6_16  0.72
2011 Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, et al. Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation. Plos Pathogens. 7: e1002391. PMID 22114562 DOI: 10.1371/journal.ppat.1002391  0.72
2011 Ehsani S, Tao R, Pocanschi CL, Ren H, Harrison PM, Schmitt-Ulms G. Evidence for retrogene origins of the prion gene family. Plos One. 6: e26800. PMID 22046361 DOI: 10.1371/journal.pone.0026800  0.72
2011 Knobbe CB, Revett TJ, Bai Y, Chow V, Jeon AH, Böhm C, Ehsani S, Kislinger T, Mount HT, Mak TW, St George-Hyslop P, Schmitt-Ulms G. Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90. Journal of Proteome Research. 10: 4388-404. PMID 21819105 DOI: 10.1021/pr200225c  0.72
2011 Pasic MD, Diamandis EP, McLaurin J, Holtzman DM, Schmitt-Ulms G, Quirion R. Alzheimer disease: advances in pathogenesis, diagnosis, and therapy. Clinical Chemistry. 57: 664-9. PMID 21310870 DOI: 10.1373/clinchem.2011.161828  0.72
2011 Ehsani S, Huo H, Salehzadeh A, Pocanschi CL, Watts JC, Wille H, Westaway D, Rogaeva E, St George-Hyslop PH, Schmitt-Ulms G. Family reunion--the ZIP/prion gene family. Progress in Neurobiology. 93: 405-20. PMID 21163327 DOI: 10.1016/j.pneurobio.2010.12.001  0.72
2010 St George-Hyslop P, Schmitt-Ulms G. Alzheimer's disease: Selectively tuning gamma-secretase. Nature. 467: 36-7. PMID 20811445 DOI: 10.1038/467036a  0.72
2010 Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH. Proteome-wide identification of mycobacterial pupylation targets. Molecular Systems Biology. 6: 386. PMID 20631680 DOI: 10.1038/msb.2010.39  0.72
2010 Daude N, Ng V, Watts JC, Genovesi S, Glaves JP, Wohlgemuth S, Schmitt-Ulms G, Young H, McLaurin J, Fraser PE, Westaway D. Wild-type Shadoo proteins convert to amyloid-like forms under native conditions. Journal of Neurochemistry. 113: 92-104. PMID 20067571 DOI: 10.1111/j.1471-4159.2010.06575.x  0.72
2009 Shi T, Weerasekera R, Yan C, Reginold W, Ball H, Kislinger T, Schmitt-Ulms G. Method for the affinity purification of covalently linked peptides following cyanogen bromide cleavage of proteins. Analytical Chemistry. 81: 9885-95. PMID 19924875 DOI: 10.1021/ac901373q  0.72
2009 Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Won AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. Plos Pathogens. 5: e1000608. PMID 19798432 DOI: 10.1371/journal.ppat.1000608  0.72
2009 Schmitt-Ulms G, Ehsani S, Watts JC, Westaway D, Wille H. Evolutionary descent of prion genes from the ZIP family of metal ion transporters. Plos One. 4: e7208. PMID 19784368 DOI: 10.1371/journal.pone.0007208  0.72
2009 Pardossi-Piquard R, Böhm C, Chen F, Kanemoto S, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. TMP21 transmembrane domain regulates gamma-secretase cleavage. The Journal of Biological Chemistry. 284: 28634-41. PMID 19710022 DOI: 10.1074/jbc.M109.059345  0.72
2009 Elschenbroich S, Ignatchenko V, Sharma P, Schmitt-Ulms G, Gramolini AO, Kislinger T. Peptide separations by on-line MudPIT compared to isoelectric focusing in an off-gel format: application to a membrane-enriched fraction from C2C12 mouse skeletal muscle cells. Journal of Proteome Research. 8: 4860-9. PMID 19670906 DOI: 10.1021/pr900318k  0.72
2009 Schmitt-Ulms G, Matenia D, Drewes G, Mandelkow EM. Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles. Cell Motility and the Cytoskeleton. 66: 661-72. PMID 19536824 DOI: 10.1002/cm.20394  0.72
2009 Pardossi-Piquard R, Yang SP, Kanemoto S, Gu Y, Chen F, Böhm C, Sevalle J, Li T, Wong PC, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. The Journal of Biological Chemistry. 284: 16298-307. PMID 19369254 DOI: 10.1074/jbc.M109.000067  0.72
2008 Gortzak-Uzan L, Ignatchenko A, Evangelou AI, Agochiya M, Brown KA, St Onge P, Kireeva I, Schmitt-Ulms G, Brown TJ, Murphy J, Rosen B, Shaw P, Jurisica I, Kislinger T. A proteome resource of ovarian cancer ascites: integrated proteomic and bioinformatic analyses to identify putative biomarkers. Journal of Proteome Research. 7: 339-51. PMID 18076136 DOI: 10.1021/pr0703223  0.72
2008 Bai Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, Wakutani Y, Bagshaw R, Mathews PM, Fraser PE, Westaway D, St George-Hyslop P, Schmitt-Ulms G. The in vivo brain interactome of the amyloid precursor protein. Molecular & Cellular Proteomics : McP. 7: 15-34. PMID 17934213 DOI: 10.1074/mcp.M700077-MCP200  0.72
2008 Weerasekera R, Shi T, Schmitt-Ulms G. Chapter 11 Covalent Trapping of Protein Interactions in Complex Systems Comprehensive Analytical Chemistry. 52. DOI: 10.1016/S0166-526X(08)00211-0  0.72
2007 Weerasekera R, She YM, Markham KA, Bai Y, Opalka N, Orlicky S, Sicheri F, Kislinger T, Schmitt-Ulms G. Interactome and interface protocol (2IP): a novel strategy for high sensitivity topology mapping of protein complexes. Proteomics. 7: 3835-52. PMID 17960736 DOI: 10.1002/pmic.200700688  0.72
2007 Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, et al. The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. The Embo Journal. 26: 4038-50. PMID 17703189 DOI: 10.1038/sj.emboj.7601830  0.72
2007 Markham K, Bai Y, Schmitt-Ulms G. Co-immunoprecipitations revisited: an update on experimental concepts and their implementation for sensitive interactome investigations of endogenous proteins. Analytical and Bioanalytical Chemistry. 389: 461-73. PMID 17583802 DOI: 10.1007/s00216-007-1385-x  0.72
2007 Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, ... ... Schmitt-Ulms G, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nature Genetics. 39: 168-77. PMID 17220890 DOI: 10.1038/ng1943  0.72
2006 Weerasekera R, Schmitt-Ulms G. Crosslinking strategies for the study of membrane protein complexes and protein interaction interfaces. Biotechnology & Genetic Engineering Reviews. 23: 41-62. PMID 22530501  0.72
2006 Rogaeva E, Zadikoff C, Ponesse J, Schmitt-Ulms G, Kawarai T, Sato C, Salehi-Rad S, St George-Hyslop P, Lang AE. Childhood onset in familial prion disease with a novel mutation in the PRNP gene. Archives of Neurology. 63: 1016-21. PMID 16831973 DOI: 10.1001/archneur.63.7.1016  0.72
2006 Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, et al. TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature. 440: 1208-12. PMID 16641999 DOI: 10.1038/nature04667  0.72
2004 Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, Kawarai T, Katayama T, Schmidt SD, Mathews PM, Schmitt-Ulms G, Fraser PE, St George-Hyslop P. Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. The Journal of Biological Chemistry. 279: 46455-63. PMID 15322109 DOI: 10.1074/jbc.M406289200  0.72
2004 Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA. Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. Nature Biotechnology. 22: 724-31. PMID 15146195 DOI: 10.1038/nbt969  0.72
2004 Gu Y, Sanjo N, Chen F, Hasegawa H, Petit A, Ruan X, Li W, Shier C, Kawarai T, Schmitt-Ulms G, Westaway D, St George-Hyslop P, Fraser PE. The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities. The Journal of Biological Chemistry. 279: 31329-36. PMID 15123598 DOI: 10.1074/jbc.M401548200  0.72
2003 Hansen KC, Schmitt-Ulms G, Chalkley RJ, Hirsch J, Baldwin MA, Burlingame AL. Mass spectrometric analysis of protein mixtures at low levels using cleavable 13C-isotope-coded affinity tag and multidimensional chromatography. Molecular & Cellular Proteomics : McP. 2: 299-314. PMID 12766231 DOI: 10.1074/mcp.M300021-MCP200  0.72
2001 Schmitt-Ulms G, Legname G, Baldwin MA, Ball HL, Bradon N, Bosque PJ, Crossin KL, Edelman GM, DeArmond SJ, Cohen FE, Prusiner SB. Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. Journal of Molecular Biology. 314: 1209-25. PMID 11743735 DOI: 10.1006/jmbi.2000.5183  0.72
2001 Peretz D, Williamson RA, Kaneko K, Vergara J, Leclerc E, Schmitt-Ulms G, Mehlhorn IR, Legname G, Wormald MR, Rudd PM, Dwek RA, Burton DR, Prusiner SB. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature. 412: 739-43. PMID 11507642 DOI: 10.1038/35089090  0.72
1995 Drewes G, Trinczek B, Illenberger S, Biernat J, Schmitt-Ulms G, Meyer HE, Mandelkow EM, Mandelkow E. Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262. The Journal of Biological Chemistry. 270: 7679-88. PMID 7706316  0.72
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