| Year |
Citation |
Score |
| 2018 |
Chen H, Volgraf M, Do S, Kolesnikov A, Shore DG, Verma VA, Villemure E, Wang L, Chen Y, Hu B, Lu AJ, Wu G, Xu X, Yuen PW, Zhang Y, ... ... Estrada AA, et al. Discovery of a Potent (4R,5S)-4-Fluoro-5-Methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist and its Methylene Phosphate Prodrug Guided By Molecular Modeling. Journal of Medicinal Chemistry. PMID 29590749 DOI: 10.1021/Acs.Jmedchem.8B00117 |
0.664 |
|
| 2015 |
Shore DGM, Wasik KA, Lyssikatos JP, Estrada AA. Minisci alkylations of electron-deficient pyrimidines with alkyl carboxylic acids Tetrahedron Letters. 56: 4063-4066. DOI: 10.1016/J.Tetlet.2015.04.123 |
0.437 |
|
| 2014 |
Estrada AA, Chan BK, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chen H, Dominguez SL, Dotson J, Drummond J, Flagella M, Fuji R, Gill A, Halladay J, Harris SF, et al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. Journal of Medicinal Chemistry. 57: 921-36. PMID 24354345 DOI: 10.1021/Jm401654J |
0.3 |
|
| 2013 |
Chan BK, Estrada AA, Chen H, Atherall J, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Dominguez SL, Drummond J, Gill A, Kleinheinz T, Le Pichon CE, Medhurst AD, Liu X, et al. Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor. Acs Medicinal Chemistry Letters. 4: 85-90. PMID 24900567 DOI: 10.1021/Ml3003007 |
0.306 |
|
| 2013 |
Estrada AA, Shore DG, Blackwood E, Chen YH, Deshmukh G, Ding X, Dipasquale AG, Epler JA, Friedman LS, Koehler MF, Liu L, Malek S, Nonomiya J, Ortwine DF, Pei Z, et al. Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR). Journal of Medicinal Chemistry. 56: 3090-101. PMID 23473235 DOI: 10.1021/Jm400194N |
0.343 |
|
| 2012 |
Estrada AA, Liu X, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chan BK, Chen H, Ding X, DiPasquale AG, Dominguez SL, Dotson J, Drummond J, Flagella M, Flynn S, et al. Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. Journal of Medicinal Chemistry. 55: 9416-33. PMID 22985112 DOI: 10.1021/Jm301020Q |
0.312 |
|
| 2011 |
Estrada AA, Lyssikatos JP, St-Jean F, Bergeron P. Access to saturated fused pyrimidine derivatives via a flexible N -vinyl tertiary enamide synthesis Synlett. 2387-2391. DOI: 10.1055/S-0030-1261228 |
0.474 |
|
| 2010 |
Hanan EJ, Chan BK, Estrada AA, Shore DG, Lyssikatos JP. Mild and general one-pot reduction and cyclization of aromatic and heteroaromatic 2-nitroamines to bicyclic 2 H -imidazoles Synlett. 2759-2764. DOI: 10.1055/S-0030-1259007 |
0.363 |
|
| 2009 |
Nicolaou KC, Chen JS, Edmonds DJ, Estrada AA. Recent advances in the chemistry and biology of naturally occurring antibiotics. Angewandte Chemie (International Ed. in English). 48: 660-719. PMID 19130444 DOI: 10.1002/Anie.200801695 |
0.468 |
|
| 2009 |
Nicolaou KC, Chen JS, Edmonds DJ, Estrada AA. Fortschritte in der Chemie und Biologie natürlicher Antibiotika Angewandte Chemie. 121: 670-732. DOI: 10.1002/Ange.200801695 |
0.355 |
|
| 2007 |
Nicolaou KC, Estrada AA, Freestone GC, Lee SH, Alvarez-Mico X. New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems. Tetrahedron. 63: 6088-6114. PMID 20606766 DOI: 10.1016/J.Tet.2007.03.072 |
0.483 |
|
| 2006 |
Nicolaou KC, Estrada AA, Sang HL, Freestone GC. Synthesis of highly substituted N-hydroxyindoles through 1,5-Addition of carbon nucleophiles to in situ generated unsaturated nitrones Angewandte Chemie - International Edition. 45: 5364-5368. PMID 16847981 DOI: 10.1002/Anie.200601808 |
0.526 |
|
| 2005 |
Nicolaou KC, Zak M, Rahimipour S, Estrada AA, Lee SH, O'Brate A, Giannakakou P, Ghadiri MR. Discovery of a biologically active thiostrepton fragment. Journal of the American Chemical Society. 127: 15042-4. PMID 16248640 DOI: 10.1021/Ja0552803 |
0.666 |
|
| 2005 |
Nicolaou KC, Zak M, Safina BS, Estrada AA, Lee SH, Nevalainen M. Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis Journal of the American Chemical Society. 127: 11176-11183. PMID 16076225 DOI: 10.1021/Ja052934Z |
0.763 |
|
| 2005 |
Nicolaou KC, Safina BS, Zak M, Lee SH, Nevalainen M, Bella M, Estrada AA, Funke C, Zécri FJ, Bulat S. Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks. Journal of the American Chemical Society. 127: 11159-75. PMID 16076224 DOI: 10.1021/Ja0529337 |
0.756 |
|
| 2005 |
Nicolaou KC, Sang HL, Estrada AA, Zak M. Construction of substituted N-hydroxyindoles: Synthesis of a nocathiacin I model system Angewandte Chemie - International Edition. 44: 3736-3740. PMID 15892095 DOI: 10.1002/Anie.200500724 |
0.734 |
|
| 2005 |
Nicolaou KC, Estrada AA, Zak M, Lee SH, Safina BS. A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide Angewandte Chemie - International Edition. 44: 1378-1382. PMID 15674985 DOI: 10.1002/Anie.200462207 |
0.704 |
|
| 2005 |
Nicolaou K, Safina B, Zak M, Lee S, Navalainen M, Bella M, Estrada A, Funke C, Zecri F, Bulat S. Synthesis of Thiostrepton Synfacts. 2006: 0014-0014. DOI: 10.1055/S-2005-921667 |
0.749 |
|
| 2005 |
Nicolaou KC, Lee SH, Estrada AA, Zak M. Construction of Substituted N-Hydroxyindoles Synfacts. 2005: 199-199. DOI: 10.1055/S-2005-916069 |
0.68 |
|
| 2004 |
Nicolaou KC, Safina BS, Zak M, Estrada AA, Lee SH. Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle. Angewandte Chemie (International Ed. in English). 43: 5087-92. PMID 15372631 DOI: 10.1002/Anie.200461340 |
0.772 |
|
| 2004 |
Nicolaou KC, Zak M, Safina BS, Lee SH, Estrada AA. Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis. Angewandte Chemie (International Ed. in English). 43: 5092-7. PMID 15372630 DOI: 10.1002/Anie.200461341 |
0.763 |
|
| Show low-probability matches. |