Howard S. Young - Publications

Biochemistry University of Alberta, Edmonton, Alberta, Canada 

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lysyk L, Brassard R, Arutyunova E, Siebert V, Jiang Z, Takyi E, Morrison M, Young HS, Lemberg MK, O'Donoghue AJ, Lemieux MJ. Insights into the catalytic properties of the mitochondrial rhomboid protease PARL. The Journal of Biological Chemistry. 100383. PMID 33556373 DOI: 10.1016/j.jbc.2021.100383  0.48
2020 Vuong W, Khan MB, Fischer C, Arutyunova E, Lamer T, Shields J, Saffran HA, McKay RT, van Belkum MJ, Joyce MA, Young HS, Tyrrell DL, Vederas JC, Lemieux MJ. Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature Communications. 11: 5409. PMID 33082353 DOI: 10.1038/s41467-020-19339-y  0.48
2020 Vuong W, Khan MB, Fischer C, Arutyunova E, Lamer T, Shields J, Saffran HA, McKay RT, van Belkum MJ, Joyce MA, Young HS, Tyrrell DL, Vederas JC, Lemieux MJ. Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature Communications. 11: 4282. PMID 32855413 DOI: 10.1038/S41467-020-18096-2  0.48
2019 Glaves JP, Primeau JO, Gorski PA, Espinoza-Fonseca LM, Lemieux MJ, Young HS. Interaction of a Sarcolipin Pentamer and Monomer with the Sarcoplasmic Reticulum Calcium Pump, SERCA. Biophysical Journal. PMID 31858977 DOI: 10.1016/J.Bpj.2019.11.3385  0.96
2019 Young HS, Lemieux MJ. Regulating the regulator: intramembrane proteolysis of vesicular trafficking proteins and the SERCA regulator phospholamban. Embo Reports. PMID 30804015 DOI: 10.15252/Embr.201947792  0.48
2019 Glaves JP, Primeau JO, Espinoza-Fonseca LM, Lemieux MJ, Young HS. The Phospholamban Pentamer Alters Function of the Sarcoplasmic Reticulum Calcium Pump SERCA. Biophysical Journal. PMID 30712785 DOI: 10.1016/J.Bpj.2019.01.013  0.96
2018 Panigrahi R, Matsui T, Song AH, Caldo KMP, Young HS, Weselake RJ, Lemieux MJ. Intrinsic disorder in the regulatory N-terminal domain of diacylglycerol acyltransferase 1 from Brassica napus. Scientific Reports. 8: 16665. PMID 30420764 DOI: 10.1038/S41598-018-34339-1  0.48
2018 Arutyunova E, Jiang Z, Yang J, Kulepa AN, Young HS, Verhelst S, O'Donoghue AJ, Lemieux MJ. An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases. Biological Chemistry. PMID 30044760 DOI: 10.1515/Hsz-2018-0255  0.48
2018 Primeau JO, Armanious GP, Fisher ME, Young HS. The SarcoEndoplasmic Reticulum Calcium ATPase. Sub-Cellular Biochemistry. 87: 229-258. PMID 29464562 DOI: 10.1007/978-981-10-7757-9_8  0.96
2017 Gorski PA, Ceholski DK, Young HS. Structure-Function Relationship of the SERCA Pump and Its Regulation by Phospholamban and Sarcolipin. Advances in Experimental Medicine and Biology. 981: 77-119. PMID 29594859 DOI: 10.1007/978-3-319-55858-5_5  0.8
2017 Smeazzetto S, Armanious GP, Moncelli MR, Bak JJ, Lemieux MJ, Young HS, Tadini-Buoninsegni F. Conformational memory in the association of the transmembrane protein phospholamban with the sarcoplasmic reticulum calcium pump SERCA. The Journal of Biological Chemistry. PMID 29081402 DOI: 10.1074/Jbc.M117.794453  0.48
2016 Vázquez-Fernández E, Vos MR, Afanasyev P, Cebey L, Sevillano AM, Vidal E, Rosa I, Renault L, Ramos A, Peters PJ, Fernández JJ, van Heel M, Young HS, Requena JR, Wille H. The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy. Plos Pathogens. 12: e1005835. PMID 27606840 DOI: 10.1371/Journal.Ppat.1005835  0.8
2016 Arutyunova E, Smithers CC, Corradi V, Espiritu AC, Young HS, Tieleman DP, Lemieux MJ. Probing catalytic rate enhancement during intramembrane proteolysis. Biological Chemistry. PMID 27071148 DOI: 10.1515/Hsz-2016-0124  0.48
2016 Glaves JP, Primeau JO, Young HS. Two-Dimensional Crystallization of the Ca(2+)-ATPase for Electron Crystallography. Methods in Molecular Biology (Clifton, N.J.). 1377: 421-41. PMID 26695053 DOI: 10.1007/978-1-4939-3179-8_38  0.96
2016 Glaves JP, Primeau JO, Young HS. Two-dimensional crystallization of the Ca2+-ATPase for electron crystallography Methods in Molecular Biology. 1377: 421-440. DOI: 10.1007/978-1-4939-3179-8_38  0.96
2015 Gorski PA, Trieber CA, Ashrafi G, Young HS. Regulation of the sarcoplasmic reticulum calcium pump by divergent phospholamban isoforms in zebrafish. The Journal of Biological Chemistry. 290: 6777-88. PMID 25593315 DOI: 10.1074/Jbc.M114.585604  0.8
2015 Young HS, Ceholski DK, Trieber CA. Deception in simplicity: hereditary phospholamban mutations in dilated cardiomyopathy. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 93: 1-7. PMID 25563649 DOI: 10.1139/Bcb-2014-0080  0.8
2014 Abrol N, Smolin N, Armanious G, Ceholski DK, Trieber CA, Young HS, Robia SL. Phospholamban C-terminal residues are critical determinants of the structure and function of the calcium ATPase regulatory complex. The Journal of Biological Chemistry. 289: 25855-66. PMID 25074938 DOI: 10.1074/Jbc.M114.562579  0.8
2014 Müller M, Kunz HH, Schroeder JI, Kemp G, Young HS, Neuhaus HE. Decreased capacity for sodium export out of Arabidopsis chloroplasts impairs salt tolerance, photosynthesis and plant performance. The Plant Journal : For Cell and Molecular Biology. 78: 646-58. PMID 24617758 DOI: 10.1111/Tpj.12501  0.8
2013 Gorski PA, Glaves JP, Vangheluwe P, Young HS. Sarco(endo)plasmic reticulum calcium ATPase (SERCA) inhibition by sarcolipin is encoded in its luminal tail. The Journal of Biological Chemistry. 288: 8456-67. PMID 23362265 DOI: 10.1074/Jbc.M112.446161  0.8
2013 Smeazzetto S, Saponaro A, Young HS, Moncelli MR, Thiel G. Structure-function relation of phospholamban: modulation of channel activity as a potential regulator of SERCA activity. Plos One. 8: e52744. PMID 23308118 DOI: 10.1371/Journal.Pone.0052744  0.8
2013 Cortez LM, Kumar J, Renault L, Young HS, Sim VL. Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism. The Journal of Biological Chemistry. 288: 4772-81. PMID 23283973 DOI: 10.1074/Jbc.M112.414581  0.8
2013 Glaves JP, Gorski PA, Alier K, Ma L, Renault L, Primeau JO, Jhamandas JH, Young HS. Distinct morphological and electrophysiological properties of an elk prion peptide. Peptides. 40: 49-56. PMID 23262353 DOI: 10.1016/J.Peptides.2012.12.011  0.8
2012 Ceholski DK, Trieber CA, Holmes CF, Young HS. Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A. The Journal of Biological Chemistry. 287: 26596-605. PMID 22707725 DOI: 10.1074/Jbc.M112.382713  0.8
2012 Gorski PA, Trieber CA, Larivière E, Schuermans M, Wuytack F, Young HS, Vangheluwe P. Transmembrane helix 11 is a genuine regulator of the endoplasmic reticulum Ca2+ pump and acts as a functional parallel of β-subunit on α-Na+,K+-ATPase. The Journal of Biological Chemistry. 287: 19876-85. PMID 22528494 DOI: 10.1074/jbc.M111.335620  0.8
2012 Ceholski DK, Trieber CA, Young HS. Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy. The Journal of Biological Chemistry. 287: 16521-9. PMID 22427649 DOI: 10.1074/Jbc.M112.360859  0.8
2011 Chaulk SG, Thede GL, Kent OA, Xu Z, Gesner EM, Veldhoen RA, Khanna SK, Goping IS, MacMillan AM, Mendell JT, Young HS, Fahlman RP, Glover JN. Role of pri-miRNA tertiary structure in miR-17~92 miRNA biogenesis. Rna Biology. 8: 1105-14. PMID 21955497 DOI: 10.4161/Rna.8.6.17410  0.8
2011 Misono KS, Philo JS, Arakawa T, Ogata CM, Qiu Y, Ogawa H, Young HS. Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase. The Febs Journal. 278: 1818-29. PMID 21375693 DOI: 10.1111/J.1742-4658.2011.08083.X  0.8
2011 Glaves JP, Trieber CA, Ceholski DK, Stokes DL, Young HS. Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump. Journal of Molecular Biology. 405: 707-23. PMID 21108950 DOI: 10.1016/J.Jmb.2010.11.014  0.8
2010 Glaves JP, Fisher L, Ward A, Young HS. Helical crystallization of two example membrane proteins MsbA and the Ca(2+)-ATPase. Methods in Enzymology. 483: 143-59. PMID 20888473 DOI: 10.1016/S0076-6879(10)83007-1  0.8
2009 Trieber CA, Afara M, Young HS. Effects of phospholamban transmembrane mutants on the calcium affinity, maximal activity, and cooperativity of the sarcoplasmic reticulum calcium pump. Biochemistry. 48: 9287-96. PMID 19708671 DOI: 10.1021/Bi900852M  0.8
2009 Catalucci D, Latronico MV, Ceci M, Rusconi F, Young HS, Gallo P, Santonastasi M, Bellacosa A, Brown JH, Condorelli G. Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17. The Journal of Biological Chemistry. 284: 28180-7. PMID 19696029 DOI: 10.1074/Jbc.M109.036566  0.8
2009 Laursen M, Bublitz M, Moncoq K, Olesen C, Møller JV, Young HS, Nissen P, Morth JP. Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase. The Journal of Biological Chemistry. 284: 13513-8. PMID 19289472 DOI: 10.1074/Jbc.C900031200  0.8
2009 Ogawa H, Qiu Y, Huang L, Tam-Chang SW, Young HS, Misono KS. Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy. The Febs Journal. 276: 1347-55. PMID 19187227 DOI: 10.1111/J.1742-4658.2009.06870.X  0.8
2008 Kemp G, Young H, Fliegel L. Structure and function of the human Na+/H+ exchanger isoform Channels. 2: 329-336. PMID 19001864 DOI: 10.4161/Chan.2.5.6898  0.8
2008 Afara MR, Trieber CA, Ceholski DK, Young HS. Peptide inhibitors use two related mechanisms to alter the apparent calcium affinity of the sarcoplasmic reticulum calcium pump. Biochemistry. 47: 9522-30. PMID 18702513 DOI: 10.1021/Bi800880Q  0.8
2008 Seidel K, Andronesi OC, Krebs J, Griesinger C, Young HS, Becker S, Baldus M. Structural characterization of Ca(2+)-ATPase-bound phospholamban in lipid bilayers by solid-state nuclear magnetic resonance (NMR) spectroscopy. Biochemistry. 47: 4369-76. PMID 18355039 DOI: 10.1021/Bi7024194  0.8
2008 Moncoq K, Kemp G, Li X, Fliegel L, Young HS. Dimeric structure of human Na+/H+ exchanger isoform 1 overproduced in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 283: 4145-54. PMID 18077454 DOI: 10.1074/Jbc.M704844200  0.8
2007 Moncoq K, Trieber CA, Young HS. The molecular basis for cyclopiazonic acid inhibition of the sarcoplasmic reticulum calcium pump. The Journal of Biological Chemistry. 282: 9748-57. PMID 17259168 DOI: 10.1074/Jbc.M611653200  0.8
2006 Afara MR, Trieber CA, Glaves JP, Young HS. Rational design of peptide inhibitors of the sarcoplasmic reticulum calcium pump. Biochemistry. 45: 8617-27. PMID 16834336 DOI: 10.1021/Bi0523761  0.8
2006 Stokes DL, Pomfret AJ, Rice WJ, Glaves JP, Young HS. Interactions between Ca2+-ATPase and the pentameric form of phospholamban in two-dimensional co-crystals. Biophysical Journal. 90: 4213-23. PMID 16533842 DOI: 10.1529/Biophysj.105.079640  0.8
2005 Andronesi OC, Becker S, Seidel K, Heise H, Young HS, Baldus M. Determination of membrane protein structure and dynamics by magic-angle-spinning solid-state NMR spectroscopy. Journal of the American Chemical Society. 127: 12965-74. PMID 16159291 DOI: 10.1021/Ja0530164  0.8
2005 Trieber CA, Douglas JL, Afara M, Young HS. The effects of mutation on the regulatory properties of phospholamban in co-reconstituted membranes. Biochemistry. 44: 3289-97. PMID 15736939 DOI: 10.1021/Bi047878D  0.8
2005 Douglas JL, Trieber CA, Afara M, Young HS. Rapid, high-yield expression and purification of Ca2+-ATPase regulatory proteins for high-resolution structural studies. Protein Expression and Purification. 40: 118-25. PMID 15721779 DOI: 10.1016/J.Pep.2004.11.015  0.8
2004 Young HS, Stokes DL. The mechanics of calcium transport. The Journal of Membrane Biology. 198: 55-63. PMID 15138745 DOI: 10.1007/S00232-004-0666-Y  0.8
2003 Young HS, Herbette LG, Skita V. Alpha-bungarotoxin binding to acetylcholine receptor membranes studied by low angle X-ray diffraction. Biophysical Journal. 85: 943-53. PMID 12885641 DOI: 10.1016/S0006-3495(03)74533-0  0.8
2003 Young HS, Dang H, Lai Y, DeRosier DJ, Khan S. Variable symmetry in Salmonella typhimurium flagellar motors. Biophysical Journal. 84: 571-7. PMID 12524310 DOI: 10.1016/S0006-3495(03)74877-2  0.8
2001 Young HS, Jones LR, Stokes DL. Locating phospholamban in co-crystals with Ca(2+)-ATPase by cryoelectron microscopy. Biophysical Journal. 81: 884-94. PMID 11463632 DOI: 10.1016/S0006-3495(01)75748-7  0.8
2001 Young HS, Xu C, Zhang P, Stokes DL. Locating the thapsigargin-binding site on Ca(2+)-ATPase by cryoelectron microscopy. Journal of Molecular Biology. 308: 231-40. PMID 11327764 DOI: 10.1006/Jmbi.2001.4558  0.8
2001 Rice WJ, Young HS, Martin DW, Sachs JR, Stokes DL. Structure of Na+,K+-ATPase at 11-A resolution: comparison with Ca2+-ATPase in E1 and E2 states. Biophysical Journal. 80: 2187-97. PMID 11325721 DOI: 10.1016/S0006-3495(01)76191-7  0.8
1998 Young HS, Reddy LG, Jones LR, Stokes DL. Co-reconstitution and co-crystallization of phospholamban and Ca(2+)-ATPase. Annals of the New York Academy of Sciences. 853: 103-15. PMID 10603940 DOI: 10.1111/J.1749-6632.1998.Tb08260.X  0.8
1998 Shi D, Lewis MR, Young HS, Stokes DL. Three-dimensional crystals of Ca2+-ATPase from sarcoplasmic reticulum: merging electron diffraction tilt series and imaging the (h, k, 0) projection. Journal of Molecular Biology. 284: 1547-64. PMID 9878370 DOI: 10.1006/Jmbi.1998.2283  0.8
1997 Young HS, Rigaud JL, Lacapère JJ, Reddy LG, Stokes DL. How to make tubular crystals by reconstitution of detergent-solubilized Ca2(+)-ATPase. Biophysical Journal. 72: 2545-58. PMID 9168030 DOI: 10.1016/S0006-3495(97)78898-2  0.8
1996 Cheong GW, Young HS, Ogawa H, Toyoshima C, Stokes DL. Lamellar stacking in three-dimensional crystals of Ca2+-ATPase from sarcoplasmic reticulum Biophysical Journal. 70: 1689-1699. PMID 8785327 DOI: 10.1016/S0006-3495(96)79731-X  0.8
1992 Chester DW, Skita V, Young HS, Mavromoustakos T, Strittmatter P. Bilayer structure and physical dynamics of the cytochrome b5 dimyristoylphosphatidylcholine interaction Biophysical Journal. 61: 1224-1243. PMID 1600082 DOI: 10.1016/S0006-3495(92)81932-X  0.8
1992 Young HS, Skita V, Mason RP, Herbette LG. Molecular basis for the inhibition of 1,4-dihydropyridine calcium channel drugs binding to their receptors by a nonspecific site interaction mechanism Biophysical Journal. 61: 1244-1255. PMID 1318093 DOI: 10.1016/S0006-3495(92)81933-1  0.8
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