Mi Hee Lim, Ph.D. - Publications

Affiliations: 
2008-2013 Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
 2013-2018 Chemistry Ulsan National Institute of Science and Technology, Ulsan, South Korea 
 2018- Chemistry Korea Advanced Institute of Science and Technology, Daejeon, South Korea 
Area:
Bioinorganic Chemistry, Chemical Biology
Website:
http://chem.kaist.ac.kr/main/

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Han J, Yoon J, Shin J, Nam E, Qian T, Li Y, Park K, Lee SH, Lim MH. Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-β. Nature Chemistry. PMID 35817963 DOI: 10.1038/s41557-022-00984-3  0.839
2021 Han J, Du Z, Lim MH. Mechanistic Insight into the Design of Chemical Tools to Control Multiple Pathogenic Features in Alzheimer's Disease. Accounts of Chemical Research. PMID 34606227 DOI: 10.1021/acs.accounts.1c00457  0.857
2021 Nam G, Suh JM, Yi Y, Lim MH. Drug repurposing: small molecules against Cu(II)-amyloid-β and free radicals. Journal of Inorganic Biochemistry. 224: 111592. PMID 34482237 DOI: 10.1016/j.jinorgbio.2021.111592  0.844
2021 Nam E, Han J, Choi S, Lim MH. Distinct impact of glycation towards the aggregation and toxicity of murine and human amyloid-β. Chemical Communications (Cambridge, England). PMID 34254069 DOI: 10.1039/d1cc02695j  0.808
2020 Yi Y, Lin Y, Han J, Lee HJ, Park N, Nam G, Park YS, Lee YH, Lim MH. Impact of sphingosine and acetylsphingosines on the aggregation and toxicity of metal-free and metal-treated amyloid-β. Chemical Science. 12: 2456-2466. PMID 34164011 DOI: 10.1039/d0sc04366d  0.866
2020 Nam G, Hong M, Lee J, Lee HJ, Ji Y, Kang J, Baik MH, Lim MH. Multiple reactivities of flavonoids towards pathological elements in Alzheimer's disease: structure-activity relationship. Chemical Science. 11: 10243-10254. PMID 34094290 DOI: 10.1039/d0sc02046j  0.836
2020 Kim M, Park MH, Nam G, Lee M, Kang J, Song IS, Choi MK, Jin HK, Bae JS, Lim MH. A Glycosylated Prodrug to Attenuate Neuroinflammation and Improve Cognitive Deficits in Alzheimer's Disease Transgenic Mice. Molecular Pharmaceutics. PMID 33241681 DOI: 10.1021/acs.molpharmaceut.0c00677  0.809
2020 Yang M, Lee SC, Kim M, Lim MH, Kim C. A multi-functional picolinohydrazide-based chemosensor for colorimetric detection of iron and dual responsive detection of hypochlorite. Spectrochimica Acta. Part a, Molecular and Biomolecular Spectroscopy. 245: 118899. PMID 32932033 DOI: 10.1016/J.Saa.2020.118899  0.519
2020 Nam G, Ji Y, Lee HJ, Kang J, Yi Y, Kim M, Lin Y, Lee YH, Lim MH. Correction to "Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease". Acs Chemical Neuroscience. PMID 32285655 DOI: 10.1021/Acschemneuro.0C00179  0.799
2020 Kim M, Kang J, Lee M, Han J, Nam G, Tak E, Kim MS, Lee HJ, Nam E, Park J, Oh SJ, Lee JY, Lee JY, Baik MH, Lim MH. Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia. Journal of the American Chemical Society. PMID 32233474 DOI: 10.1021/Jacs.9B13100  0.853
2020 Han J, Lee HJ, Kim KY, Nam G, Chae J, Lim MH. Mechanistic approaches for chemically modifying the coordination sphere of copper-amyloid-β complexes. Proceedings of the National Academy of Sciences of the United States of America. PMID 32102914 DOI: 10.1073/Pnas.1916944117  0.837
2019 Kim MS, Yun D, Chae JB, So H, Lee H, Kim KT, Kim M, Lim MH, Kim C. A Novel Thiophene-Based Fluorescent Chemosensor for the Detection of Zn and CN: Imaging Applications in Live Cells and Zebrafish. Sensors (Basel, Switzerland). 19. PMID 31835755 DOI: 10.3390/S19245458  0.567
2019 Quintanar L, Lim MH. Metal ions and degenerative diseases. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 31758264 DOI: 10.1007/s00775-019-01744-4  0.319
2019 Park MH, Lee M, Nam G, Kim M, Kang J, Choi BJ, Jeong MS, Park KH, Han WH, Tak E, Kim MS, Lee J, Lin Y, Lee YH, Song IS, ... ... Lim MH, et al. ,'-Diacetyl--phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer's disease transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 31685616 DOI: 10.1073/Pnas.1916318116  0.82
2019 Buccella D, Lim MH, Morrow JR. Metals in Biology: From Metallomics to Trafficking. Inorganic Chemistry. 58: 13505-13508. PMID 31630526 DOI: 10.1021/Acs.Inorgchem.9B02965  0.32
2019 Nam E, Nam G, Lim MH. Synaptic Copper, Amyloid-β, and Neurotransmitters in Alzheimer's Disease. Biochemistry. PMID 31603659 DOI: 10.1021/Acs.Biochem.9B00775  0.823
2019 Kang J, Nam JS, Lee HJ, Nam G, Rhee HW, Kwon TH, Lim MH. Chemical strategies to modify amyloidogenic peptides using iridium(iii) complexes: coordination and photo-induced oxidation. Chemical Science. 10: 6855-6862. PMID 31391908 DOI: 10.1039/C9Sc00931K  0.833
2019 Lee HJ, Lee YG, Kang J, Yang SH, Kim JH, Ghisaidoobe ABT, Kang HJ, Lee SR, Lim MH, Chung SJ. Correction: Monitoring metal-amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening. Chemical Science. 10: 6390-6392. PMID 31367302 DOI: 10.1039/c9sc90118c  0.823
2019 Lin Y, Sahoo BR, Ozawa D, Kinoshita M, Kang J, Lim MH, Okumura M, Huh YH, Moon E, Jang JH, Lee HJ, Ryu KY, Ham S, Won HS, Ryu KS, et al. Diverse Structural Conversion and Aggregation Pathways of Alzheimer's Amyloid-β (1-40). Acs Nano. PMID 31310506 DOI: 10.1021/Acsnano.9B01578  0.793
2019 Nam G, Ji Y, Lee HJ, Kang J, Yi Y, Kim M, Lin Y, Lee YH, Lim MH. Orobol: An Isoflavone with Regulatory Multifunctionality against Four Pathological Factors of Alzheimer's Disease. Acs Chemical Neuroscience. PMID 31199606 DOI: 10.1021/Acschemneuro.9B00232  0.856
2019 Yi Y, Han J, Park MH, Park N, Nam E, Jin HK, Bae JS, Lim MH. Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)-amyloid-β. Chemical Communications (Cambridge, England). PMID 31042246 DOI: 10.1039/C9Cc01005J  0.794
2019 Chae JB, Yun D, Kim S, Lee H, Kim M, Lim MH, Kim KT, Kim C. Fluorescent determination of zinc by a quinoline-based chemosensor in aqueous media and zebrafish. Spectrochimica Acta. Part a, Molecular and Biomolecular Spectroscopy. 219: 74-82. PMID 31030049 DOI: 10.1016/J.Saa.2019.04.044  0.57
2019 Lee HJ, Lee YG, Kang J, Yang SH, Kim JH, Ghisaidoobe ABT, Kang HJ, Lee SR, Lim MH, Chung SJ. Monitoring metal-amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening. Chemical Science. 10: 1000-1007. PMID 30774894 DOI: 10.1039/C8Sc04943B  0.865
2019 Nam G, Lim MH. Intertwined Pathologies of Amyloid-β and Metal Ions in Alzheimer’s Disease: Metal–Amyloid-β Chemistry Letters. 48: 951-960. DOI: 10.1246/Cl.190281  0.828
2019 Kang JH, Yang M, Yun D, Kim M, Lee H, Kim K, Lim MH, Kim C. A dual-response sensor based on NBD for the highly selective determination of sulfide in living cells and zebrafish New Journal of Chemistry. 43: 4029-4035. DOI: 10.1039/C8Nj06352D  0.516
2019 Hwang SM, Yun D, Lee H, Kim M, Lim MH, Kim K, Kim C. Relay detection of Zn2+ and S2− by a quinoline-based fluorescent chemosensor in aqueous media and zebrafish Dyes and Pigments. 165: 264-272. DOI: 10.1016/J.Dyepig.2019.02.027  0.576
2019 Lee M, Kim M, Tikum AF, Lee HJ, Thamilarasan V, Lim MH, Kim J. A near-infrared fluorescent probe for amyloid-β aggregates Dyes and Pigments. 162: 97-103. DOI: 10.1016/J.Dyepig.2018.10.013  0.822
2018 Kim S, Lee HJ, Nam E, Jeong D, Cho J, Lim MH, You Y. Tailoring Hydrophobic Interactions between Probes and Amyloid-β Peptides for Fluorescent Monitoring of Amyloid-β Aggregation. Acs Omega. 3: 5141-5154. PMID 31458729 DOI: 10.1021/acsomega.8b00286  0.808
2018 Suh JM, Kim G, Kang J, Lim MH. Strategies Employing Transition Metal Complexes To Modulate Amyloid-β Aggregation. Inorganic Chemistry. PMID 30556393 DOI: 10.1021/Acs.Inorgchem.8B02813  0.807
2018 Kim MS, Jo TG, Yang M, Han J, Lim MH, Kim C. A fluorescent and colorimetric Schiff base chemosensor for the detection of Zn and Cu: Application in live cell imaging and colorimetric test kit. Spectrochimica Acta. Part a, Molecular and Biomolecular Spectroscopy. 211: 34-43. PMID 30502582 DOI: 10.1016/J.Saa.2018.11.058  0.632
2018 Yun JY, Chae JB, Kim M, Lim MH, Kim C. A multiple target chemosensor for the sequential fluorescence detection of Zn and S and the colorimetric detection of Fe in aqueous media and living cells. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. PMID 30397697 DOI: 10.1039/C8Pp00408K  0.549
2018 Hong S, Go YK, Derrick JS, Han S, Kim J, Lim MH, Kim SH. Advanced Electron Paramagnetic Resonance Studies of a Ternary Complex of Copper, Amyloid-β, and a Chemical Regulator. Inorganic Chemistry. PMID 30239184 DOI: 10.1021/acs.inorgchem.8b01824  0.38
2018 Savelieff MG, Nam G, Kang J, Lee HJ, Lee M, Lim MH. Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade. Chemical Reviews. PMID 30095897 DOI: 10.1021/Acs.Chemrev.8B00138  0.805
2018 Lee HJ, Savelieff MG, Kang J, Brophy MB, Nakashige TG, Lee SJC, Nolan EM, Lim MH. Calprotectin influences the aggregation of metal-free and metal-bound amyloid-β by direct interaction. Metallomics : Integrated Biometal Science. PMID 30046785 DOI: 10.1039/C8Mt00091C  0.867
2018 Nam E, Derrick JS, Lee S, Kang J, Han J, Lee SJC, Chung SW, Lim MH. Regulatory Activities of Dopamine and Its Derivatives towards Metal-Free and Metal-Induced Amyloid-β Aggregation, Oxidative Stress, and Inflammation in Alzheimer's Disease. Acs Chemical Neuroscience. PMID 29782798 DOI: 10.1021/Acschemneuro.8B00122  0.86
2018 Jung JM, Kang JH, Han J, Lee H, Lim MH, Kim K, Kim C. A novel “off-on” type fluorescent chemosensor for detection of Zn2+ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo Sensors and Actuators B: Chemical. 267: 58-69. DOI: 10.1016/J.Snb.2018.03.063  0.664
2018 Yun JY, Jo TG, Han J, Jang HJ, Lim MH, Kim C. A highly sensitive and selective fluorescent chemosensor for the sequential recognition of Zn2+ and S2− in living cells and aqueous media Sensors and Actuators B: Chemical. 255: 3108-3116. DOI: 10.1016/J.Snb.2017.09.136  0.639
2018 Kang JH, Han J, Lee H, Lim MH, Kim K, Kim C. A water-soluble fluorescence chemosensor for the sequential detection of Zn2+ and pyrophosphate in living cells and zebrafish Dyes and Pigments. 152: 131-138. DOI: 10.1016/J.Dyepig.2018.01.039  0.634
2017 Han J, Lee HJ, Kim KY, Lee SJC, Suh JM, Cho J, Chae J, Lim MH. Tuning Structures and Properties for Developing Novel Chemical Tools toward Distinct Pathogenic Elements in Alzheimer's Disease. Acs Chemical Neuroscience. PMID 29283241 DOI: 10.1021/Acschemneuro.7B00454  0.869
2017 Nam E, Han J, Suh JM, Yi Y, Lim MH. Link of impaired metal ion homeostasis to mitochondrial dysfunction in neurons. Current Opinion in Chemical Biology. 43: 8-14. PMID 29100100 DOI: 10.1016/J.Cbpa.2017.09.009  0.765
2017 Beck MW, Derrick JS, Suh JM, Kim M, Korshavn KJ, Kerr RA, Cho WJ, Larsen SD, Ruotolo BT, Ramamoorthy A, Lim MH. Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease. Chemmedchem. 12: 1828-1838. PMID 28990338 DOI: 10.1002/Cmdc.201700456  0.824
2017 Jones MR, Mathieu E, Dyrager C, Faissner S, Vaillancourt Z, Korshavn KJ, Lim MH, Ramamoorthy A, Wee Yong V, Tsutsui S, Stys PK, Storr T. Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease. Chemical Science. 8: 5636-5643. PMID 28989601 DOI: 10.1039/C7Sc01269A  0.636
2017 Choi TS, Lee HJ, Han JY, Lim MH, Kim HI. Molecular Insights into Human Serum Albumin as a Receptor of Amyloid-β in the Extracellular Region. Journal of the American Chemical Society. PMID 28930473 DOI: 10.1021/Jacs.7B08584  0.811
2017 Ji Y, Lee HJ, Kim M, Nam G, Lee SJC, Cho J, Park CM, Lim MH. Strategic Design of 2,2'-Bipyridine Derivatives to Modulate Metal-Amyloid-β Aggregation. Inorganic Chemistry. PMID 28485587 DOI: 10.1021/Acs.Inorgchem.7B00782  0.875
2017 Jung JM, Lee JJ, Nam E, Lim MH, Kim C, Harrison RG. A zinc fluorescent sensor used to detect mercury (II) and hydrosulfide. Spectrochimica Acta. Part a, Molecular and Biomolecular Spectroscopy. 178: 203-211. PMID 28189093 DOI: 10.1016/J.Saa.2017.02.006  0.564
2017 Korshavn KJ, Satriano C, Lin Y, Zhang R, Dulchavsky M, Bhunia A, Ivanova MI, Lee YH, La Rosa C, Lim MH, Ramamoorthy A. Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β. The Journal of Biological Chemistry. 292: 4638-4650. PMID 28154182 DOI: 10.1074/Jbc.M116.764092  0.565
2017 Derrick JS, Lee J, Lee SJ, Kim Y, Nam E, Tak H, Kang J, Lee M, Kim SH, Park K, Cho J, Lim MH. Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides. Journal of the American Chemical Society. PMID 28098992 DOI: 10.1021/Jacs.6B09681  0.859
2017 Lee HJ, Korshavn KJ, Nam Y, Kang J, Paul TJ, Kerr RA, Youn IS, Ozbil M, Kim KS, Ruotolo BT, Prabhakar R, Ramamoorthy A, Lim MH. Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer's Disease. Chemistry (Weinheim An Der Bergstrasse, Germany). 23: 2706-2715. PMID 28004889 DOI: 10.1002/Chem.201605401  0.855
2017 Kang J, Lee SJ, Nam JS, Lee HJ, Kang MG, Korshavn KJ, Kim HT, Cho J, Ramamoorthy A, Rhee HW, Kwon TH, Lim MH. An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation. Chemistry (Weinheim An Der Bergstrasse, Germany). 23: 1645-1653. PMID 27862428 DOI: 10.1002/Chem.201604751  0.811
2017 Jo TG, Jung JM, Han J, Lim MH, Kim C. A single fluorescent chemosensor for multiple targets of Cu2+, Fe2+/3+ and Al3+ in living cells and a near-perfect aqueous solution Rsc Advances. 7: 28723-28732. DOI: 10.1039/C7Ra05565J  0.606
2017 Jeong HY, Lee SY, Han J, Lim MH, Kim C. Thiophene and diethylaminophenol-based “turn-on” fluorescence chemosensor for detection of Al 3+ and F − in a near-perfect aqueous solution Tetrahedron. 73: 2690-2697. DOI: 10.1016/J.Tet.2017.03.069  0.6
2017 Jung JM, Lee SY, Nam E, Lim MH, Kim C. A highly selective turn-on chemosensor for Zn2+ in aqueous media and living cells Sensors and Actuators B: Chemical. 244: 1045-1053. DOI: 10.1016/J.Snb.2017.01.076  0.57
2017 Jo TG, Bok KH, Han J, Lim MH, Kim C. Colorimetric detection of Fe 3+ and Fe 2+ and sequential fluorescent detection of Al 3+ and pyrophosphate by an imidazole-based chemosensor in a near-perfect aqueous solution Dyes and Pigments. 139: 136-147. DOI: 10.1016/J.Dyepig.2016.11.052  0.598
2017 Beck MW, Derrick JS, Suh J, Kim M, Korshavn KJ, Kerr RA, Cho WJ, Larsen SD, Ruotolo BT, Ramamoorthy A, Lim MH. Front Cover: Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease (ChemMedChem 22/2017) Chemmedchem. 12: 1818-1818. DOI: 10.1002/Cmdc.201700711  0.747
2016 Lee SJC, Choi TS, Lee JW, Lee HJ, Mun DG, Akashi S, Lee SW, Lim MH, Kim HI. Structure and assembly mechanisms of toxic human islet amyloid polypeptide oligomers associated with copper. Chemical Science. 7: 5398-5406. PMID 30155193 DOI: 10.1039/C6Sc00153J  0.771
2016 Lee SJ, Nam E, Lee HJ, Savelieff MG, Lim MH. Towards an understanding of amyloid-β oligomers: characterization, toxicity mechanisms, and inhibitors. Chemical Society Reviews. PMID 27878186 DOI: 10.1039/C6Cs00731G  0.846
2016 Beck MW, Derrick JS, Kerr RA, Oh SB, Cho WJ, Lee SJ, Ji Y, Han J, Tehrani ZA, Suh N, Kim S, Larsen SD, Kim KS, Lee JY, Ruotolo BT, ... Lim MH, et al. Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer's disease. Nature Communications. 7: 13115. PMID 27734843 DOI: 10.1038/Ncomms13115  0.807
2016 Nam JS, Kang MG, Kang J, Park SY, Lee SJ, Kim HT, Seo JK, Kwon OH, Lim MH, Rhee HW, Kwon TH. Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications. Journal of the American Chemical Society. PMID 27494510 DOI: 10.1021/Jacs.6B05302  0.677
2016 Bera S, Korshavn KJ, Kar RK, Lim MH, Ramamoorthy A, Bhunia A. Biophysical insights into the membrane interaction of the core amyloid-forming Aβ40 fragment K16-K28 and its role in the pathogenesis of Alzheimer's disease. Physical Chemistry Chemical Physics : Pccp. 18: 16890-901. PMID 27282693 DOI: 10.1039/C6Cp02023B  0.512
2016 Park JS, Nam E, Lee HK, Lim MH, Rhee HW. In Cellulo Mapping of Subcellular Localized Bilirubin. Acs Chemical Biology. PMID 27232847 DOI: 10.1021/Acschembio.6B00017  0.513
2016 Jones MR, Dyrager C, Hoarau M, Korshavn KJ, Lim MH, Ramamoorthy A, Storr T. Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-β peptide aggregation. Journal of Inorganic Biochemistry. 158: 131-138. PMID 27133802 DOI: 10.1016/J.Jinorgbio.2016.04.022  0.583
2016 Derrick JS, Kerr RA, Korshavn KJ, McLane MJ, Kang J, Nam E, Ramamoorthy A, Ruotolo BT, Lim MH. Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer's Disease. Inorganic Chemistry. 55: 5000-13. PMID 27119456 DOI: 10.1021/Acs.Inorgchem.6B00525  0.871
2016 Lee JJ, Kim YS, Nam E, Lee SY, Lim MH, Kim C. A PET-based fluorometric chemosensor for the determination of mercury(ii) and pH, and hydrolysis reaction-based colorimetric detection of hydrogen sulfide. Dalton Transactions (Cambridge, England : 2003). PMID 26928649 DOI: 10.1039/C6Dt00147E  0.551
2016 Korshavn KJ, Bhunia A, Lim MH, Ramamoorthy A. Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation. Chemical Communications (Cambridge, England). 52: 882-5. PMID 26553596 DOI: 10.1039/C5Cc08634E  0.541
2016 Lee SJC, Choi TS, Lee JW, Lee HJ, Mun DG, Akashi S, Lee SW, Lim MH, Kim HI. Structure and assembly mechanisms of toxic human islet amyloid polypeptide oligomers associated with copper Chemical Science. 7: 5398-5406. DOI: 10.1039/c6sc00153j  0.772
2016 Jo TG, Lee JJ, Nam E, Bok KH, Lim MH, Kim C. A highly selective fluorescent sensor for the detection of Al3+ and CN− in aqueous solution: biological applications and DFT calculations New Journal of Chemistry. 40: 8918-8927. DOI: 10.1039/C6Nj01544A  0.53
2016 Lee HJ, Kerr RA, Korshavn KJ, Lee J, Kang J, Ramamoorthy A, Ruotolo BT, Lim MH. Effects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation Inorganic Chemistry Frontiers. 3: 381-392. DOI: 10.1039/C5Qi00219B  0.875
2016 Choi YW, Lee JJ, Nam E, Lim MH, Kim C. A fluorescent chemosensor for Al3+ based on julolidine and tryptophan moieties Tetrahedron. DOI: 10.1016/J.Tet.2016.02.066  0.542
2015 Porter MR, Kochi A, Karty JA, Lim MH, Zaleski JM. Chelation-induced diradical formation as an approach to modulation of the amyloid-β aggregation pathway. Chemical Science. 6: 1018-1026. PMID 29560189 DOI: 10.1039/C4Sc01979B  0.712
2015 Beck MW, Oh SB, Kerr RA, Lee HJ, Kim SH, Kim S, Jang M, Ruotolo BT, Lee JY, Lim MH. A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimer's disease. Chemical Science. 6: 1879-1886. PMID 28706643 DOI: 10.1039/C4Sc03239J  0.853
2015 Korshavn KJ, Jang M, Kwak YJ, Kochi A, Vertuani S, Bhunia A, Manfredini S, Ramamoorthy A, Lim MH. Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives. Scientific Reports. 5: 17842. PMID 26657338 DOI: 10.1038/Srep17842  0.81
2015 Derrick JS, Kerr RA, Nam Y, Oh SB, Lee HJ, Earnest KG, Suh N, Peck KL, Ozbil M, Korshavn KJ, Ramamoorthy A, Prabhakar R, Merino EJ, Shearer J, Lee JY, ... ... Lim MH, et al. A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms. Journal of the American Chemical Society. 137: 14785-97. PMID 26575890 DOI: 10.1021/Jacs.5B10043  0.797
2015 Shadfar S, Hwang CJ, Lim MS, Choi DY, Hong JT. Involvement of inflammation in Alzheimer's disease pathogenesis and therapeutic potential of anti-inflammatory agents. Archives of Pharmacal Research. PMID 26289122 DOI: 10.1007/s12272-015-0648-x  0.326
2015 Kochi A, Lee HJ, Vithanarachchi SM, Padmini V, Allen MJ, Lim MH. Inhibitory Activity of Curcumin Derivatives Towards Metal-Free and Metal-Induced Amyloid-β Aggregation. Current Alzheimer Research. 12: 415-23. PMID 25938870 DOI: 10.2174/1567205012666150504150125  0.871
2015 Derrick JS, Lim MH. Tools of the trade: investigations into design strategies of small molecules to target components in Alzheimer's disease. Chembiochem : a European Journal of Chemical Biology. 16: 887-98. PMID 25773481 DOI: 10.1002/cbic.201402718  0.358
2015 Beck MW, Oh SB, Kerr RA, Lee HJ, Kim SH, Kim S, Jang M, Ruotolo BT, Lee JY, Lim MH. A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimer's disease Chemical Science. 6: 1879-1886. DOI: 10.1039/c4sc03239j  0.67
2015 Porter MR, Kochi A, Karty JA, Lim MH, Zaleski JM. Chelation-induced diradical formation as an approach to modulation of the amyloid-β aggregation pathway Chemical Science. 6: 1018-1026. DOI: 10.1039/c4sc01979b  0.667
2014 DeToma AS, Krishnamoorthy J, Nam Y, Lee HJ, Brender JR, Kochi A, Lee D, Onnis V, Congiu C, Manfredini S, Vertuani S, Balboni G, Ramamoorthy A, Lim MH. Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species. Chemical Science. 5: 4851-4862. PMID 25383163 DOI: 10.1039/C4Sc01531B  0.868
2014 DeToma AS, Dengler-Crish CM, Deb A, Braymer JJ, Penner-Hahn JE, van der Schyf CJ, Lim MH, Crish SD. Abnormal metal levels in the primary visual pathway of the DBA/2J mouse model of glaucoma. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 27: 1291-301. PMID 25190614 DOI: 10.1007/S10534-014-9790-Z  0.751
2014 Chang CJ, Cravatt BF, Johnson DS, Lim MH. Molecular medicine and neurodegenerative diseases. Chemical Society Reviews. 43: 6668-71. PMID 25105517 DOI: 10.1039/C4Cs90065K  0.471
2014 Savelieff MG, DeToma AS, Derrick JS, Lim MH. The ongoing search for small molecules to study metal-associated amyloid-β species in Alzheimer's disease. Accounts of Chemical Research. 47: 2475-82. PMID 25080056 DOI: 10.1021/Ar500152X  0.877
2014 Geldenhuys WJ, Kochi A, Lin L, Sutariya V, Dluzen DE, Van der Schyf CJ, Lim MH. Methyl Yellow: A Potential Drug Scaffold for Parkinson's Disease. Chembiochem : a European Journal of Chemical Biology. PMID 25045125 DOI: 10.1002/cbic.201300770  0.58
2014 Lee HJ, Korshavn KJ, Kochi A, Derrick JS, Lim MH. Cholesterol and metal ions in Alzheimer's disease. Chemical Society Reviews. 43: 6672-82. PMID 24710074 DOI: 10.1039/C4Cs00005F  0.835
2014 Lee S, Zheng X, Krishnamoorthy J, Savelieff MG, Park HM, Brender JR, Kim JH, Derrick JS, Kochi A, Lee HJ, Kim C, Ramamoorthy A, Bowers MT, Lim MH. Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease. Journal of the American Chemical Society. 136: 299-310. PMID 24397771 DOI: 10.1021/Ja409801P  0.873
2014 Savelieff MG, Liu Y, Senthamarai RR, Korshavn KJ, Lee HJ, Ramamoorthy A, Lim MH. A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease. Chemical Communications (Cambridge, England). 50: 5301-3. PMID 24326305 DOI: 10.1039/C3Cc48473D  0.848
2014 Beck MW, Pithadia AS, Detoma AS, Korshavn KJ, Lim MH. Ligand Design to Target and Modulate Metal-Protein Interactions in Neurodegenerative Diseases Ligand Design in Medicinal Inorganic Chemistry. 257-286. DOI: 10.1002/9781118697191.ch10  0.815
2013 Ramamoorthy A, Lim MH. Structural characterization and inhibition of toxic amyloid-β oligomeric intermediates. Biophysical Journal. 105: 287-8. PMID 23870249 DOI: 10.1016/J.Bpj.2013.05.004  0.62
2013 Liu Y, Kochi A, Pithadia AS, Lee S, Nam Y, Beck MW, He X, Lee D, Lim MH. Tuning reactivity of diphenylpropynone derivatives with metal-associated amyloid-β species via structural modifications. Inorganic Chemistry. 52: 8121-30. PMID 23805940 DOI: 10.1021/Ic400851W  0.849
2013 Barrios AM, Cohen SM, Lim MH. Medicinal inorganic chemistry: a web themed issue. Chemical Communications (Cambridge, England). 49: 5910-1. PMID 23715532 DOI: 10.1039/C3Cc90159A  0.317
2013 Soper MT, DeToma AS, Hyung SJ, Lim MH, Ruotolo BT. Amyloid-β-neuropeptide interactions assessed by ion mobility-mass spectrometry. Physical Chemistry Chemical Physics : Pccp. 15: 8952-61. PMID 23612608 DOI: 10.1039/C3Cp50721A  0.795
2013 Savelieff MG, Lee S, Liu Y, Lim MH. Untangling amyloid-β, tau, and metals in Alzheimer's disease. Acs Chemical Biology. 8: 856-65. PMID 23506614 DOI: 10.1021/Cb400080F  0.824
2013 Hyung SJ, DeToma AS, Brender JR, Lee S, Vivekanandan S, Kochi A, Choi JS, Ramamoorthy A, Ruotolo BT, Lim MH. Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. Proceedings of the National Academy of Sciences of the United States of America. 110: 3743-8. PMID 23426629 DOI: 10.1073/Pnas.1220326110  0.868
2013 Kochi A, Eckroat TJ, Green KD, Mayhoub AS, Lim MH, Garneau-Tsodikova S. A novel hybrid of 6-chlorotacrine and metal-amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation Chemical Science. 4: 4137-4145. DOI: 10.1039/C3Sc51902C  0.773
2012 Pithadia AS, Kochi A, Soper MT, Beck MW, Liu Y, Lee S, DeToma AS, Ruotolo BT, Lim MH. Reactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species. Inorganic Chemistry. 51: 12959-67. PMID 23153071 DOI: 10.1021/Ic302084G  0.845
2012 McConnell AJ, Lim MH, Olmon ED, Song H, Dervan EE, Barton JK. Luminescent properties of ruthenium(II) complexes with sterically expansive ligands bound to DNA defects. Inorganic Chemistry. 51: 12511-20. PMID 23113594 DOI: 10.1021/Ic3019524  0.769
2012 Jones MR, Service EL, Thompson JR, Wang MC, Kimsey IJ, DeToma AS, Ramamoorthy A, Lim MH, Storr T. Dual-function triazole-pyridine derivatives as inhibitors of metal-induced amyloid-β aggregation. Metallomics : Integrated Biometal Science. 4: 910-20. PMID 22825244 DOI: 10.1039/C2Mt20113E  0.849
2012 He X, Park HM, Hyung SJ, DeToma AS, Kim C, Ruotolo BT, Lim MH. Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species. Dalton Transactions (Cambridge, England : 2003). 41: 6558-66. PMID 22437427 DOI: 10.1039/C2Dt12207C  0.86
2012 Pithadia AS, Lim MH. Metal-associated amyloid-β species in Alzheimer's disease. Current Opinion in Chemical Biology. 16: 67-73. PMID 22366383 DOI: 10.1016/j.cbpa.2012.01.016  0.531
2012 DeToma AS, Salamekh S, Ramamoorthy A, Lim MH. Misfolded proteins in Alzheimer's disease and type II diabetes. Chemical Society Reviews. 41: 608-21. PMID 21818468 DOI: 10.1039/C1Cs15112F  0.832
2012 Braymer JJ, Merrill NM, Lim MH. Characterization of pyridinylimine and pyridinylmethylamine derivatives and their corresponding metal complexes Inorganica Chimica Acta. 380: 261-268. DOI: 10.1016/j.ica.2011.08.056  0.311
2011 Cho J, Jeon S, Wilson SA, Liu LV, Kang EA, Braymer JJ, Lim MH, Hedman B, Hodgson KO, Valentine JS, Solomon EI, Nam W. Structure and reactivity of a mononuclear non-haem iron(III)-peroxo complex. Nature. 478: 502-5. PMID 22031443 DOI: 10.1038/Nature10535  0.56
2011 Braymer JJ, Choi JS, DeToma AS, Wang C, Nam K, Kampf JW, Ramamoorthy A, Lim MH. Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species. Inorganic Chemistry. 50: 10724-34. PMID 21954910 DOI: 10.1021/Ic2012205  0.856
2011 DeToma AS, Choi JS, Braymer JJ, Lim MH. Myricetin: a naturally occurring regulator of metal-induced amyloid-β aggregation and neurotoxicity. Chembiochem : a European Journal of Chemical Biology. 12: 1198-201. PMID 21538759 DOI: 10.1002/Cbic.201000790  0.826
2011 Choi JS, Braymer JJ, Park SK, Mustafa S, Chae J, Lim MH. Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-β aggregation. Metallomics : Integrated Biometal Science. 3: 284-91. PMID 21210061 DOI: 10.1039/c0mt00077a  0.475
2010 Braymer JJ, Detoma AS, Choi JS, Ko KS, Lim MH. Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011: 623051. PMID 21197068 DOI: 10.4061/2011/623051  0.856
2010 Choi JS, Braymer JJ, Nanga RP, Ramamoorthy A, Lim MH. Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 107: 21990-5. PMID 21131570 DOI: 10.1073/Pnas.1006091107  0.661
2010 Lim MH, Jin SW, Lee YJ, Jhon G, Nam W, Kim C. ChemInform Abstract: Electronic Effect of Iron(III) Porphyrin Complexes on the Epoxidation of Cyclohexene: Epoxidation versus Hydroxylation. Cheminform. 33: no-no. DOI: 10.1002/CHIN.200214054  0.397
2010 Lim MH, Lee YJ, Goh YM, Nam W, Kim C. ChemInform Abstract: Hydroxylation of Aliphatic Hydrocarbons with m-Chloroperbenzoic Acid Catalyzed by Electron-Deficient Iron(III) Porphyrin Complexes. Cheminform. 30: no-no. DOI: 10.1002/CHIN.199934087  0.387
2009 Hindo SS, Mancino AM, Braymer JJ, Liu Y, Vivekanandan S, Ramamoorthy A, Lim MH. Small molecule modulators of copper-induced Abeta aggregation. Journal of the American Chemical Society. 131: 16663-5. PMID 19877631 DOI: 10.1021/Ja907045H  0.861
2009 Mancino AM, Hindo SS, Kochi A, Lim MH. Effects of clioquinol on metal-triggered amyloid-beta aggregation revisited. Inorganic Chemistry. 48: 9596-8. PMID 19817493 DOI: 10.1021/Ic9014256  0.855
2009 Lim MH, Song H, Olmon ED, Dervan EE, Barton JK. Sensitivity of Ru(bpy)2dppz2+ luminescence to DNA defects. Inorganic Chemistry. 48: 5392-7. PMID 19453124 DOI: 10.1021/Ic900407N  0.759
2007 Lim MH, Lau IH, Barton JK. DNA strand cleavage near a CC mismatch directed by a metalloinsertor. Inorganic Chemistry. 46: 9528-30. PMID 17918931 DOI: 10.1021/Ic701598K  0.523
2007 Lim MH, Lippard SJ. Metal-based turn-on fluorescent probes for sensing nitric oxide. Accounts of Chemical Research. 40: 41-51. PMID 17226944 DOI: 10.1021/Ar950149T  0.552
2006 Lim MH, Wong BA, Pitcock WH, Mokshagundam D, Baik MH, Lippard SJ. Direct nitric oxide detection in aqueous solution by copper(II) fluorescein complexes. Journal of the American Chemical Society. 128: 14364-73. PMID 17076510 DOI: 10.1021/Ja064955E  0.622
2006 Lim MH, Lippard SJ. Fluorescent nitric oxide detection by copper complexes bearing anthracenyl and dansyl fluorophore ligands. Inorganic Chemistry. 45: 8980-9. PMID 17054358 DOI: 10.1021/Ic0609913  0.484
2006 Lim MH, Kuang C, Lippard SJ. Nitric oxide-induced fluorescence enhancement by displacement of dansylated ligands from cobalt. Chembiochem : a European Journal of Chemical Biology. 7: 1571-6. PMID 16789059 DOI: 10.1002/Cbic.200600042  0.474
2006 Lim MH, Xu D, Lippard SJ. Visualization of nitric oxide in living cells by a copper-based fluorescent probe. Nature Chemical Biology. 2: 375-80. PMID 16732295 DOI: 10.1038/Nchembio794  0.587
2005 Oh NY, Seo MS, Lim MH, Consugar MB, Park MJ, Rohde JU, Han J, Kim KM, Kim J, Que L, Nam W. Self-hydroxylation of perbenzoic acids at a nonheme iron(II) center. Chemical Communications (Cambridge, England). 5644-6. PMID 16292376 DOI: 10.1039/B511302D  0.394
2005 Lim MH, Lippard SJ. Copper complexes for fluorescence-based NO detection in aqueous solution. Journal of the American Chemical Society. 127: 12170-1. PMID 16131164 DOI: 10.1021/Ja053150O  0.494
2005 Smith RC, Tennyson AG, Lim MH, Lippard SJ. Conjugated polymer-based fluorescence turn-on sensor for nitric oxide. Organic Letters. 7: 3573-5. PMID 16048345 DOI: 10.1021/Ol0513903  0.612
2005 Park SE, Song WJ, Ryu YO, Lim MH, Song R, Kim KM, Nam W. Parallel mechanistic studies on the counterion effect of manganese salen and porphyrin complexes on olefin epoxidation by iodosylarenes. Journal of Inorganic Biochemistry. 99: 424-31. PMID 15621274 DOI: 10.1016/J.Jinorgbio.2004.10.015  0.408
2005 Woodroofe CC, Lim MH, Bu W, Lippard SJ. Synthesis of isomerically pure carboxylate- and sulfonate-substituted xanthene fluorophores Tetrahedron. 61: 3097-3105. DOI: 10.1016/j.tet.2005.01.024  0.394
2005 Woodroofe CC, Lim MH, Bu W, Lippard SJ. Synthesis of Isomerically Pure Carboxylate- and Sulfonate-Substituted Xanthene Fluorophores. Cheminform. 36. DOI: 10.1016/J.Tet.2005.01.024  0.428
2004 Rohde JU, Torelli S, Shan X, Lim MH, Klinker EJ, Kaizer J, Chen K, Nam W, Que L. Structural insights into nonheme alkylperoxoiron(III) and oxoiron(IV) intermediates by X-ray absorption spectroscopy. Journal of the American Chemical Society. 126: 16750-61. PMID 15612713 DOI: 10.1021/Ja047667W  0.41
2004 Lim MH, Lippard SJ. Fluorescence-based nitric oxide detection by ruthenium porphyrin fluorophore complexes. Inorganic Chemistry. 43: 6366-70. PMID 15446885 DOI: 10.1021/Ic035418N  0.495
2004 Hilderbrand SA, Lim MH, Lippard SJ. Dirhodium tetracarboxylate scaffolds as reversible fluorescence-based nitric oxide sensors. Journal of the American Chemical Society. 126: 4972-8. PMID 15080703 DOI: 10.1021/Ja038471J  0.467
2003 Nam W, Choi SK, Lim MH, Rohde JU, Kim I, Kim J, Kim C, Que L. Reversible formation of iodosylbenzene-iron porphyrin intermediates in the reaction of oxoiron(IV) porphyrin pi-cation radicals and iodobenzene. Angewandte Chemie (International Ed. in English). 42: 109-11. PMID 19757605 DOI: 10.1002/Anie.200390036  0.393
2003 Nam W, Park SE, Lim IK, Lim MH, Hong J, Kim J. First direct evidence for stereospecific olefin epoxidation and alkane hydroxylation by an oxoiron(IV) porphyrin complex. Journal of the American Chemical Society. 125: 14674-5. PMID 14640620 DOI: 10.1021/Ja0368204  0.416
2003 Lim MH, Rohde JU, Stubna A, Bukowski MR, Costas M, Ho RY, Munck E, Nam W, Que L. An FeIV=O complex of a tetradentate tripodal nonheme ligand. Proceedings of the National Academy of Sciences of the United States of America. 100: 3665-70. PMID 12644707 DOI: 10.1073/Pnas.0636830100  0.393
2003 Rohde JU, In JH, Lim MH, Brennessel WW, Bukowski MR, Stubna A, Münck E, Nam W, Que L. Crystallographic and spectroscopic characterization of a nonheme Fe(IV)-O complex. Science (New York, N.Y.). 299: 1037-9. PMID 12586936 DOI: 10.1126/Science.299.5609.1037  0.408
2002 Nam W, Jin SW, Lim MH, Ryu JY, Kim C. Anionic ligand effect on the nature of epoxidizing intermediates in iron porphyrin complex-catalyzed epoxidation reactions. Inorganic Chemistry. 41: 3647-52. PMID 12099867 DOI: 10.1021/Ic011145P  0.416
2002 Nam W, Kim I, Lim MH, Choi HJ, Lee JS, Jang HG. Isolation of an oxomanganese(V) porphyrin intermediate in the reaction of a manganese(III) porphyrin complex and H2O2 in aqueous solution. Chemistry (Weinheim An Der Bergstrasse, Germany). 8: 2067-71. PMID 11981891 DOI: 10.1002/1521-3765(20020503)8:9<2067::Aid-Chem2067>3.0.Co;2-V  0.37
2001 Kim Y, Nam W, Lim MH, Jin SW, Lough AJ, Kim SJ. Methoxy[meso-5,10,15,20-tetrakis-(2,6-difluorophenyl)porphyrinato]-iron(III), [Fe(TDFPP)(OCH3)] Acta Crystallographica Section C: Crystal Structure Communications. 57: 556-557. PMID 11353248 DOI: 10.1107/S0108270101003006  0.365
2001 Nam W, Oh S, Lim MH, Choi M, Han S, Jhon G. ChemInform Abstract: Temperature Effect on the Epoxidation of Olefins by an Iron(III) Porphyrin Complex and tert-Alkyl Hydroperoxides. Cheminform. 32: no-no. DOI: 10.1002/CHIN.200102105  0.394
2000 Nam W, Lim MH, Oh SY. Effect of anionic axial ligands on the formation of oxoiron(IV) porphyrin intermediates. Inorganic Chemistry. 39: 5572-5. PMID 11154575 DOI: 10.1021/Ic000502D  0.418
2000 Nam W, Lim MH, Oh SY, Lee JH, Lee HJ, Woo SK, Kim C, Shin W. Remarkable Anionic Axial Ligand Effects of Iron(III) Porphyrin Complexes on the Catalytic Oxygenations of Hydrocarbons by H(2)O(2) and the Formation of Oxoiron(IV) Porphyrin Intermediates by m-Chloroperoxybenzoic Acid This work was supported by Center for Cell Signaling Research (1999-2-122-002-4), the Korean Research Foundation (KRF-99-042-D00068), and the MOST through the Women's University Research Fund (99-N6-01-01-A-07). Angewandte Chemie (International Ed. in English). 39: 3646-3649. PMID 11091426 DOI: 10.1002/1521-3773(20001016)39:20<3646::Aid-Anie3646>3.0.Co;2-Q  0.402
2000 Nam W, Lim MH, Moon SK, Kim C. Participation of Two Distinct Hydroxylating Intermediates in Iron(III) Porphyrin Complex-Catalyzed Hydroxylation of Alkanes Journal of the American Chemical Society. 122: 10805-10809. DOI: 10.1021/Ja0010554  0.413
2000 Nam W, Lim MH, Lee HJ, Kim C. Evidence for the participation of two distinct reactive intermediates in iron(III) porphyrin complex-catalyzed-epoxidation reactions Journal of the American Chemical Society. 122: 6641-6647. DOI: 10.1021/Ja000289K  0.408
2000 Nam W, Lim MH, Oh SY, Lee JH, Lee HJ, Woo SK, Kim C, Shin W. Remarkable anionic axial ligand effects of iron(III) porphyrin complexes on the catalytic oxygenations of hydrocarbons by H2O2 and the formation of oxoiron(IV) porphyrin intermediates by m-chloroperoxybenzoic acid Angewandte Chemie - International Edition. 39: 3646-3649. DOI: 10.1002/1521-3773(20001016)39:20<3646::AID-ANIE3646>3.0.CO;2-Q  0.419
1999 Lim MH, Lee YJ, Goh YM, Nam W, Kim C. Hydroxylation of aliphatic hydrocarbons with m-chloroperbenzoic acid catalyzed by electron-deficient iron(III) porphyrin complexes Bulletin of the Chemical Society of Japan. 72: 707-713. DOI: 10.1246/Bcsj.72.707  0.395
1999 Nam W, Goh YM, Lee YJ, Lim MH, Kim C. Biomimetic Alkane Hydroxylations by an Iron(III) Porphyrin Complex with H2O2and by a High-Valent Iron(IV) Oxo Porphyrin Cation Radical Complex Inorganic Chemistry. 38: 3238-3240. DOI: 10.1021/Ic980670U  0.413
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