Heiko Heerklotz - Publications

Pharmaceutical Sciences University of Toronto, Toronto, ON, Canada 
Pharmacy, Biochemistry

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Fan HY, Heerklotz H. Digitonin does not flip across cholesterol-poor membranes. Journal of Colloid and Interface Science. 504: 283-293. PMID 28551523 DOI: 10.1016/j.jcis.2017.05.034  0.52
2016 Fan HY, Das D, Heerklotz H. "Staying out" rather than "cracking in": asymmetric membrane insertion of 12:0 lysophosphocholine. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 27715063 DOI: 10.1021/acs.langmuir.6b03292  0.52
2015 Fiedler S, Heerklotz H. Vesicle Leakage Reflects the Target Selectivity of Antimicrobial Lipopeptides from Bacillus subtilis. Biophysical Journal. 109: 2079-89. PMID 26588567 DOI: 10.1016/j.bpj.2015.09.021  0.72
2015 Lu S, Bennett WF, Ding Y, Zhang L, Fan HY, Zhao D, Zheng T, Ouyang PK, Li J, Wu Y, Xu W, Chu D, Yuan Y, Heerklotz H, Karttunen M, et al. Design and Characterization of a Multifunctional pH-Triggered Peptide C8 for Selective Anticancer Activity. Advanced Healthcare Materials. PMID 26474414 DOI: 10.1002/adhm.201500636  0.72
2015 Hovakeemian SG, Liu R, Gellman SH, Heerklotz H. Correlating antimicrobial activity and model membrane leakage induced by nylon-3 polymers and detergents. Soft Matter. 11: 6840-51. PMID 26234884 DOI: 10.1039/c5sm01521a  0.72
2015 Fan HY, Raval G, Shalviri A, May S, Wu XY, Heerklotz H. Coupled equilibria of a self-associating drug loaded into polymeric nanoparticles. Methods (San Diego, Calif.). 76: 162-70. PMID 25575744 DOI: 10.1016/j.ymeth.2014.12.015  0.72
2014 Patel H, Huynh Q, Bärlehner D, Heerklotz H. Additive and synergistic membrane permeabilization by antimicrobial (lipo)peptides and detergents. Biophysical Journal. 106: 2115-25. PMID 24853740 DOI: 10.1016/j.bpj.2014.04.006  0.72
2014 Fan HY, Nazari M, Raval G, Khan Z, Patel H, Heerklotz H. Utilizing zeta potential measurements to study the effective charge, membrane partitioning, and membrane permeation of the lipopeptide surfactin. Biochimica Et Biophysica Acta. 1838: 2306-12. PMID 24631665 DOI: 10.1016/j.bbamem.2014.02.018  0.72
2014 Shek YL, Noudeh GD, Nazari M, Heerklotz H, Abu-Ghazalah RM, Dubins DN, Chalikian TV. Folding thermodynamics of the hybrid-1 type intramolecular human telomeric G-quadruplex. Biopolymers. 101: 216-27. PMID 23775839 DOI: 10.1002/bip.22317  0.72
2013 Heerklotz H, Keller S. How membrane partitioning modulates receptor activation: parallel versus serial effects of hydrophobic ligands. Biophysical Journal. 105: 2607-10. PMID 24359728 DOI: 10.1016/j.bpj.2013.10.031  0.72
2013 Redka DS, Heerklotz H, Wells JW. Efficacy as an intrinsic property of the M(2) muscarinic receptor in its tetrameric state. Biochemistry. 52: 7405-27. PMID 24047497 DOI: 10.1021/bi4003869  0.72
2013 Shalviri A, Chan HK, Raval G, Abdekhodaie MJ, Liu Q, Heerklotz H, Wu XY. Design of pH-responsive nanoparticles of terpolymer of poly(methacrylic acid), polysorbate 80 and starch for delivery of doxorubicin. Colloids and Surfaces. B, Biointerfaces. 101: 405-13. PMID 23010048 DOI: 10.1016/j.colsurfb.2012.07.015  0.72
2012 Shalviri A, Raval G, Prasad P, Chan C, Liu Q, Heerklotz H, Rauth AM, Wu XY. pH-Dependent doxorubicin release from terpolymer of starch, polymethacrylic acid and polysorbate 80 nanoparticles for overcoming multi-drug resistance in human breast cancer cells. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 82: 587-97. PMID 22995704 DOI: 10.1016/j.ejpb.2012.09.001  0.72
2012 Nazari M, Fan HY, Heerklotz H. Effect of hydrophobic interactions on volume and thermal expansivity as derived from micelle formation. Langmuir : the Acs Journal of Surfaces and Colloids. 28: 14129-36. PMID 22950856 DOI: 10.1021/la302276n  0.72
2012 Nazari M, Kurdi M, Heerklotz H. Classifying surfactants with respect to their effect on lipid membrane order. Biophysical Journal. 102: 498-506. PMID 22325272 DOI: 10.1016/j.bpj.2011.12.029  0.72
2012 Heerklotz H, Blume A. Detergent interactions with lipid bilayers and membrane proteins Comprehensive Biophysics. 5: 63-91. DOI: 10.1016/B978-0-12-374920-8.00529-4  0.72
2011 Patel H, Tscheka C, Edwards K, Karlsson G, Heerklotz H. All-or-none membrane permeabilization by fengycin-type lipopeptides from Bacillus subtilis QST713. Biochimica Et Biophysica Acta. 1808: 2000-8. PMID 21545788 DOI: 10.1016/j.bbamem.2011.04.008  0.72
2011 Fan HY, Shek YL, Amiri A, Dubins DN, Heerklotz H, Macgregor RB, Chalikian TV. Volumetric characterization of sodium-induced G-quadruplex formation. Journal of the American Chemical Society. 133: 4518-26. PMID 21370889 DOI: 10.1021/ja110495c  0.72
2011 Fan HY, Nazari M, Chowdhury S, Heerklotz H. Volume and expansivity changes of micelle formation measured by pressure perturbation calorimetry. Langmuir : the Acs Journal of Surfaces and Colloids. 27: 1693-9. PMID 21226468 DOI: 10.1021/la1042487  0.72
2011 Frenkel M, Chirico RD, Diky V, Brown PL, Dymond JH, Goldberg RN, Goodwin ARH, Heerklotz H, Königsberger E, Ladbury JE, Marsh KN, Remeta DP, Stein SE, Wakeham WA, Williams PA. Extension of ThermoML: The IUPAC standard for thermodynamic data communications (IUPAC Recommendations 2011) Pure and Applied Chemistry. 83: 1937-1969. DOI: 10.1351/PAC-REC-11-05-01  0.72
2011 Frenkel M, Diky V, Chirico RD, Goldberg RN, Heerklotz H, Ladbury JE, Remeta DP, Dymond JH, Goodwin ARH, Marsh KN, Wakeham WA, Stein SE, Brown PL, Königsberger E, Williams PA. ThermoML: An XML-based approach for storage and exchange of experimental and critically evaluated thermophysical and thermochemical property data. 5. Speciation and complex equilibria Journal of Chemical and Engineering Data. 56: 307-316. DOI: 10.1021/je100999j  0.72
2010 Patel H, Raval G, Nazari M, Heerklotz H. Effects of glycerol and urea on micellization, membrane partitioning and solubilization by a non-ionic surfactant. Biophysical Chemistry. 150: 119-28. PMID 20417021 DOI: 10.1016/j.bpc.2010.03.015  0.72
2010 Lee S, Heerklotz H, Chalikian TV. Effects of buffer ionization in protein transition volumes. Biophysical Chemistry. 148: 144-7. PMID 20346569 DOI: 10.1016/j.bpc.2010.03.002  0.72
2010 Chirico RD, Frenkel M, Diky V, Goldberg RN, Heerklotz H, Ladbury JE, Remeta DP, Dymond JH, Goodwin ARH, Marsh KN, Wakeham WA. ThermoML -An XML-based approach for storage and exchange of experimental and critically evaluated thermophysical and thermochemical property data. 4. biomaterials Journal of Chemical and Engineering Data. 55: 1564-1572. DOI: 10.1021/je900685d  0.72
2009 Heerklotz H, Tsamaloukas AD, Keller S. Monitoring detergent-mediated solubilization and reconstitution of lipid membranes by isothermal titration calorimetry. Nature Protocols. 4: 686-97. PMID 19373233 DOI: 10.1038/nprot.2009.35  0.72
2009 Tsamaloukas AD, Beck A, Heerklotz H. Modeling the micellization behavior of mixed and pure n-alkyl-maltosides. Langmuir : the Acs Journal of Surfaces and Colloids. 25: 4393-401. PMID 19366219 DOI: 10.1021/la8033935  0.72
2009 Rayan G, Tsamaloukas AD, Macgregor RB, Heerklotz H. Helix-coil transition of DNA monitored by pressure perturbation calorimetry. The Journal of Physical Chemistry. B. 113: 1738-42. PMID 19159195 DOI: 10.1021/jp808253t  0.72
2009 Patel H, Tscheka C, Heerklotz H. Characterizing vesicle leakage by fluorescence lifetime measurements Soft Matter. 5: 2849-2851. DOI: 10.1039/b908524f  0.72
2008 Heerklotz H. Interactions of surfactants with lipid membranes. Quarterly Reviews of Biophysics. 41: 205-64. PMID 19079805 DOI: 10.1017/S0033583508004721  0.72
2008 Beck A, Tsamaloukas AD, Jurcevic P, Heerklotz H. Additive action of two or more solutes on lipid membranes. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 8833-40. PMID 18646725 DOI: 10.1021/la800682q  0.72
2007 Wassmann P, Chan C, Paul R, Beck A, Heerklotz H, Jenal U, Schirmer T. Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition. Structure (London, England : 1993). 15: 915-27. PMID 17697997 DOI: 10.1016/j.str.2007.06.016  0.72
2007 Paul R, Abel S, Wassmann P, Beck A, Heerklotz H, Jenal U. Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization. The Journal of Biological Chemistry. 282: 29170-7. PMID 17640875 DOI: 10.1074/jbc.M704702200  0.72
2007 Tsamaloukas AD, Keller S, Heerklotz H. Uptake and release protocol for assessing membrane binding and permeation by way of isothermal titration calorimetry. Nature Protocols. 2: 695-704. PMID 17406632 DOI: 10.1038/nprot.2007.98  0.72
2007 Mrosek M, Labeit D, Witt S, Heerklotz H, von Castelmur E, Labeit S, Mayans O. Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 1383-92. PMID 17215480 DOI: 10.1096/fj.06-7644com  0.72
2007 Heerklotz H, Seelig J. Leakage and lysis of lipid membranes induced by the lipopeptide surfactin. European Biophysics Journal : Ebj. 36: 305-14. PMID 17051366 DOI: 10.1007/s00249-006-0091-5  0.72
2007 Wassmann P, Chan C, Paul R, Beck A, Heerklotz H, Jenal U, Schirmer T. Structure of BeF3--Modified Response Regulator PleD: Implications for Diguanylate Cyclase Activation, Catalysis, and Feedback Inhibition (DOI:10.1016/j.str.2007.06.016) Structure. 15: 1155. DOI: 10.1016/j.str.2007.08.006  0.72
2006 Tsamaloukas A, Szadkowska H, Heerklotz H. Nonideal mixing in multicomponent lipid/detergent systems. Journal of Physics. Condensed Matter : An Institute of Physics Journal. 18: S1125-38. PMID 21690833 DOI: 10.1088/0953-8984/18/28/S02  0.72
2006 Heerklotz H, Tsamaloukas A. Gradual change or phase transition: characterizing fluid lipid-cholesterol membranes on the basis of thermal volume changes. Biophysical Journal. 91: 600-7. PMID 16632513 DOI: 10.1529/biophysj.106.082669  0.72
2006 Tsamaloukas A, Szadkowska H, Heerklotz H. Thermodynamic comparison of the interactions of cholesterol with unsaturated phospholipid and sphingomyelins. Biophysical Journal. 90: 4479-87. PMID 16581844 DOI: 10.1529/biophysj.105.080127  0.72
2006 Keller S, Heerklotz H, Jahnke N, Blume A. Thermodynamics of lipid membrane solubilization by sodium dodecyl sulfate. Biophysical Journal. 90: 4509-21. PMID 16581838 DOI: 10.1529/biophysj.105.077867  0.72
2006 Keller S, Heerklotz H, Blume A. Monitoring lipid membrane translocation of sodium dodecyl sulfate by isothermal titration calorimetry. Journal of the American Chemical Society. 128: 1279-86. PMID 16433546 DOI: 10.1021/ja056389d  0.72
2005 Keller S, Tsamaloukas A, Heerklotz H. A quantitative model describing the selective solubilization of membrane domains. Journal of the American Chemical Society. 127: 11469-76. PMID 16089477 DOI: 10.1021/ja052764q  0.72
2005 Barrow DJ, Chandrasekaran S, Heerklotz HH, Henary MM, Michniak BB, Nguyen PM, Song Y, Smith JC, Strekowski L. Mechanistic studies on percutaneous penetration enhancement by N-(4-halobenzoyl)-S,S-dimethyliminosulfuranes Journal of Lipid Research. 46: 2192-2201. PMID 16061953 DOI: 10.1194/jlr.M500123-JLR200  0.72
2005 Lichtenberg D, Goñi FM, Heerklotz H. Detergent-resistant membranes should not be identified with membrane rafts. Trends in Biochemical Sciences. 30: 430-6. PMID 15996869 DOI: 10.1016/j.tibs.2005.06.004  0.72
2005 Tsamaloukas A, Szadkowska H, Slotte PJ, Heerklotz H. Interactions of cholesterol with lipid membranes and cyclodextrin characterized by calorimetry. Biophysical Journal. 89: 1109-19. PMID 15923231 DOI: 10.1529/biophysj.105.061846  0.72
2004 Heerklotz H, Tsamaloukas A, Kita-Tokarczyk K, Strunz P, Gutberlet T. Structural, volumetric, and thermodynamic characterization of a micellar sphere-to-rod transition. Journal of the American Chemical Society. 126: 16544-52. PMID 15600359 DOI: 10.1021/ja045525w  0.72
2004 Heerklotz H. The microcalorimetry of lipid membranes Journal of Physics Condensed Matter. 16. DOI: 10.1088/0953-8984/16/15/R01  0.72
2004 Heerklotz H, Wieprecht T, Seelig J. Membrane Perturbation by the Lipopeptide Surfactin and Detergents as Studied by Deuterium NMR Journal of Physical Chemistry B. 108: 4909-4915.  0.72
2003 Heerklotz H, Szadkowska H, Anderson T, Seelig J. The sensitivity of lipid domains to small perturbations demonstrated by the effect of Triton. Journal of Molecular Biology. 329: 793-9. PMID 12787678 DOI: 10.1016/S0022-2836(03)00504-7  0.72
2002 Heerklotz H. Triton promotes domain formation in lipid raft mixtures Biophysical Journal. 83: 2693-2701. PMID 12414701  0.72
2002 Heerklotz H, Seelig J. Application of pressure perturbation calorimetry to lipid bilayers. Biophysical Journal. 82: 1445-52. PMID 11867459 DOI: 10.1016/S0006-3495(02)75498-2  0.72
2001 Heerklotz H, Seelig J. Detergent-like action of the antibiotic peptide surfactin on lipid membranes. Biophysical Journal. 81: 1547-54. PMID 11509367 DOI: 10.1016/S0006-3495(01)75808-0  0.72
2001 Heerklotz H. Membrane stress and permeabilization induced by asymmetric incorporation of compounds Biophysical Journal. 81: 184-195. PMID 11423405  0.72
2001 Heerklotz H, Epand RM. The enthalpy of acyl chain packing and the apparent water-accessible apolar surface area of phospholipids Biophysical Journal. 80: 271-279. PMID 11159400  0.72
2000 Heerklotz H, Seelig J. Titration calorimetry of surfactant-membrane partitioning and membrane solubilization. Biochimica Et Biophysica Acta. 1508: 69-85. PMID 11090819 DOI: 10.1016/S0304-4157(00)00009-5  0.72
2000 Heerklotz H, Seelig J. Correlation of membrane/water partition coefficients of detergents with the critical micelle concentration. Biophysical Journal. 78: 2435-40. PMID 10777739 DOI: 10.1016/S0006-3495(00)76787-7  0.72
2000 Gutberlet T, Kiselev M, Heerklotz H, Klose G. SANS study of mixed POPC/C12En aggregates Physica B: Condensed Matter. 276: 381-383. DOI: 10.1016/S0921-4526(99)01499-4  0.72
1999 Heerklotz HH, Binder H, Epand RM. A 'release' protocol for isothermal titration calorimetry Biophysical Journal. 76: 2606-2613. PMID 10233075  0.72
1999 Binder H, Kohlstrunk B, Heerklotz HH. Hydration and lyotropic melting of amphiphilic molecules: A thermodynamic study using humidity titration calorimetry Journal of Colloid and Interface Science. 220: 235-249. DOI: 10.1006/jcis.1999.6501  0.72
1999 Binder H, Kohlstrunk B, Heerklotz HH. A humidity titration calorimetry technique to study the thermodynamics of hydration Chemical Physics Letters. 304: 329-335.  0.72
1998 Lantzsch G, Binder H, Heerklotz H, Welzel P, Klose G. Aggregation behavior of the antibiotic moenomycin A in aqueous solution Langmuir. 14: 4095-4104.  0.72
1998 Heerklotz HH, Binder H, Schmiedel H. Excess enthalpies of mixing in phospholipid-additive membranes Journal of Physical Chemistry B. 102: 5363-5368.  0.72
1997 Heerklotz H, Binder H, Lantzsch G, Klose G, Blume A. Lipid/detergent interaction thermodynamics as a function of molecular shape Journal of Physical Chemistry B. 101: 639-645.  0.72
1996 Lantzsch G, Binder H, Heerklotz H, Wendling M, Klose G. Surface areas and packing constraints in POPC/C12EOn membranes. A time-resolved fluorescence study Biophysical Chemistry. 58: 289-302. DOI: 10.1016/0301-4622(95)00108-5  0.72
1996 Heerklotz H, Lantzsch G, Binder H, Klose G, Blume A. Thermodynamic characterization of dilute aqueous lipid/detergent mixtures of POPC and C12EO8 by means of isothermal titration calorimetry Journal of Physical Chemistry. 100: 6764-6774.  0.72
1995 Heerklotz H, Lantzsch G, Binder H, Klose G, Blume A. Application of isothermal titration calorimetry for detecting lipid membrane solubilization Chemical Physics Letters. 235: 517-520. DOI: 10.1016/0009-2614(95)00139-U  0.72
1994 Heerklotz H, Binder H, Lantzsch G, Klose G. Membrane/water partition of oligo( ethylene oxide) dodecyl ethers and its relevance for solubilization Bba - Biomembranes. 1196: 114-122. PMID 7841174 DOI: 10.1016/0005-2736(94)00222-3  0.72
1994 Heerklotz H, Binder H, Lantzsch G. Determination of the partition coefficients of the nonionic detergent C12E7 between lipid-detergent mixed membranes and water by means of Laurdan fluorescence spectroscopy Journal of Fluorescence. 4: 349-352. DOI: 10.1007/BF01881454  0.72
1994 Lantzsch G, Binder H, Heerklotz H. Surface area per molecule in lipid/C12En membranes as seen by fluorescence resonance energy transfer Journal of Fluorescence. 4: 339-343. DOI: 10.1007/BF01881452  0.72
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