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Mark Paetzel - Publications

Affiliations: 
Simon Fraser University, Burnaby, British Columbia, Canada 
Area:
Virology Biology, Biochemistry
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lee J, Kenward C, Worrall LJ, Vuckovic M, Gentile F, Ton AT, Ng M, Cherkasov A, Strynadka NCJ, Paetzel M. X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation. Nature Communications. 13: 5196. PMID 36057636 DOI: 10.1038/s41467-022-32854-4  0.333
2020 Lee J, Worrall LJ, Vuckovic M, Rosell FI, Gentile F, Ton AT, Caveney NA, Ban F, Cherkasov A, Paetzel M, Strynadka NCJ. Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. Nature Communications. 11: 5877. PMID 33208735 DOI: 10.1038/s41467-020-19662-4  0.357
2019 Paetzel M. Bacterial Signal Peptidases. Sub-Cellular Biochemistry. 92: 187-219. PMID 31214988 DOI: 10.1007/978-3-030-18768-2_7  0.397
2015 Aulakh S, Kim KH, Paetzel M. Expression and Purification of the Individual Bam Components BamB-E. Methods in Molecular Biology (Clifton, N.J.). 1329: 179-88. PMID 26427685 DOI: 10.1007/978-1-4939-2871-2_14  0.62
2014 Zhang XL, De S, McIntosh LP, Paetzel M. Structural characterization of the C3 domain of cardiac myosin binding protein C and its hypertrophic cardiomyopathy-related R502W mutant. Biochemistry. 53: 5332-42. PMID 25058872 DOI: 10.1021/Bi500784G  0.336
2014 Paetzel M. Structure and mechanism of Escherichia coli type I signal peptidase. Biochimica Et Biophysica Acta. 1843: 1497-508. PMID 24333859 DOI: 10.1016/J.Bbamcr.2013.12.003  0.478
2013 Nam SE, Paetzel M. Structure of signal peptide peptidase A with C-termini bound in the active sites: insights into specificity, self-processing, and regulation. Biochemistry. 52: 8811-22. PMID 24228759 DOI: 10.1021/Bi4011489  0.647
2013 Zhang XL, Tibbits GF, Paetzel M. The structure of cardiac troponin C regulatory domain with bound Cd2+ reveals a closed conformation and unique ion coordination. Acta Crystallographica. Section D, Biological Crystallography. 69: 722-34. PMID 23633581 DOI: 10.1107/S0907444913001182  0.383
2013 Chung IY, Paetzel M. Crystal structures of yellowtail ascites virus VP4 protease: trapping an internal cleavage site trans acyl-enzyme complex in a native Ser/Lys dyad active site. The Journal of Biological Chemistry. 288: 13068-81. PMID 23511637 DOI: 10.1074/Jbc.M112.386953  0.466
2013 Stevens CM, Okon M, McIntosh LP, Paetzel M. ¹H, ¹³C and ¹⁵N resonance assignments and peptide binding site chemical shift perturbation mapping for the Escherichia coli redox enzyme chaperone DmsD. Biomolecular Nmr Assignments. 7: 193-7. PMID 22766963 DOI: 10.1007/S12104-012-9408-8  0.452
2012 Stevens CM, Paetzel M. Purification of a Tat leader peptide by co-expression with its chaperone. Protein Expression and Purification. 84: 167-72. PMID 22609337 DOI: 10.1016/J.Pep.2012.05.002  0.359
2012 Kim KH, Aulakh S, Paetzel M. The bacterial outer membrane β-barrel assembly machinery. Protein Science : a Publication of the Protein Society. 21: 751-68. PMID 22549918 DOI: 10.1002/Pro.2069  0.595
2012 Nam SE, Kim AC, Paetzel M. Crystal structure of Bacillus subtilis signal peptide peptidase A. Journal of Molecular Biology. 419: 347-58. PMID 22472423 DOI: 10.1016/J.Jmb.2012.03.020  0.682
2011 Kim KH, Aulakh S, Tan W, Paetzel M. Crystallographic analysis of the C-terminal domain of the Escherichia coli lipoprotein BamC. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1350-8. PMID 22102230 DOI: 10.1107/S174430911103363X  0.647
2011 Liu J, Luo C, Smith PA, Chin JK, Page MG, Paetzel M, Romesberg FE. Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase. Journal of the American Chemical Society. 133: 17869-77. PMID 21999324 DOI: 10.1021/Ja207318N  0.393
2011 Kim KH, Aulakh S, Paetzel M. Crystal structure of β-barrel assembly machinery BamCD protein complex. The Journal of Biological Chemistry. 286: 39116-21. PMID 21937441 DOI: 10.1074/Jbc.M111.298166  0.654
2011 Li AY, Lee J, Borek D, Otwinowski Z, Tibbits GF, Paetzel M. Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation. Journal of Molecular Biology. 413: 699-711. PMID 21920370 DOI: 10.1016/J.Jmb.2011.08.049  0.389
2011 Lee J, Paetzel M. Structure of the catalytic domain of glucoamylase from Aspergillus niger. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 188-92. PMID 21301084 DOI: 10.1107/S1744309110049390  0.451
2011 Chung IY, Paetzel M. Crystal structure of a viral protease intramolecular acyl-enzyme complex: insights into cis-cleavage at the VP4/VP3 junction of Tellina birnavirus. The Journal of Biological Chemistry. 286: 12475-82. PMID 21288899 DOI: 10.1074/Jbc.M110.198812  0.452
2011 Kim KH, Kang HS, Okon M, Escobar-Cabrera E, McIntosh LP, Paetzel M. Structural characterization of Escherichia coli BamE, a lipoprotein component of the β-barrel assembly machinery complex. Biochemistry. 50: 1081-90. PMID 21207987 DOI: 10.1021/Bi101659U  0.661
2011 Chung IY, Paetzel M. Expression, purification and crystallization of VP4 protease from Tellina virus 1. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 157-60. PMID 21206051 DOI: 10.1107/S1744309110048803  0.393
2011 Kim KH, Paetzel M. Crystal structure of Escherichia coli BamB, a lipoprotein component of the β-barrel assembly machinery complex. Journal of Molecular Biology. 406: 667-78. PMID 21168416 DOI: 10.1016/J.Jmb.2010.12.020  0.662
2011 Kim K, Okon M, Escobar E, Kang H, McIntosh L, Paetzel M. NMR Structure of Escherichia coli BamE, a Lipoprotein Component of the beta-Barrel Assembly Machinery Complex Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Kxx/Pdb  0.561
2009 Lee J, Johnson J, Ding Z, Paetzel M, Cornell RB. Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold. The Journal of Biological Chemistry. 284: 33535-48. PMID 19783652 DOI: 10.1074/Jbc.M109.053363  0.505
2009 Luo C, Roussel P, Dreier J, Page MG, Paetzel M. Crystallographic analysis of bacterial signal peptidase in ternary complex with arylomycin A2 and a beta-sultam inhibitor. Biochemistry. 48: 8976-84. PMID 19655811 DOI: 10.1021/Bi9009538  0.383
2009 Ekici OD, Zhu J, Wah Chung IY, Paetzel M, Dalbey RE, Pei D. Profiling the substrate specificity of viral protease VP4 by a FRET-based peptide library approach. Biochemistry. 48: 5753-9. PMID 19435306 DOI: 10.1021/Bi900461E  0.391
2009 Stevens CM, Winstone TM, Turner RJ, Paetzel M. Structural analysis of a monomeric form of the twin-arginine leader peptide binding chaperone Escherichia coli DmsD. Journal of Molecular Biology. 389: 124-33. PMID 19361518 DOI: 10.1016/J.Jmb.2009.03.069  0.512
2008 Ekici OD, Paetzel M, Dalbey RE. Unconventional serine proteases: variations on the catalytic Ser/His/Asp triad configuration. Protein Science : a Publication of the Protein Society. 17: 2023-37. PMID 18824507 DOI: 10.1110/Ps.035436.108  0.447
2008 Wang P, Shim E, Cravatt B, Jacobsen R, Schoeniger J, Kim AC, Paetzel M, Dalbey RE. Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the nonconserved amino-terminal domain in the S49 protease family. Biochemistry. 47: 6361-9. PMID 18476724 DOI: 10.1021/Bi800657P  0.466
2008 Feldman AR, Shapova YA, Wu SS, Oliver DC, Heller M, McIntosh LP, Scott JK, Paetzel M. Phage display and crystallographic analysis reveals potential substrate/binding site interactions in the protein secretion chaperone CsaA from Agrobacterium tumefaciens. Journal of Molecular Biology. 379: 457-70. PMID 18462752 DOI: 10.1016/J.Jmb.2008.03.048  0.457
2008 Chan CS, Winstone TM, Chang L, Stevens CM, Workentine ML, Li H, Wei Y, Ondrechen MJ, Paetzel M, Turner RJ. Identification of residues in DmsD for twin-arginine leader peptide binding, defined through random and bioinformatics-directed mutagenesis. Biochemistry. 47: 2749-59. PMID 18247574 DOI: 10.1021/Bi702138A  0.485
2008 Kim AC, Oliver DC, Paetzel M. Crystal structure of a bacterial signal Peptide peptidase. Journal of Molecular Biology. 376: 352-66. PMID 18164727 DOI: 10.1016/J.Jmb.2007.11.080  0.545
2008 Oliver DC, Paetzel M. Crystal structure of the major periplasmic domain of the bacterial membrane protein assembly facilitator YidC. The Journal of Biological Chemistry. 283: 5208-16. PMID 18093969 DOI: 10.1074/Jbc.M708936200  0.493
2007 Lee J, Feldman AR, Delmas B, Paetzel M. Crystal structure of the VP4 protease from infectious pancreatic necrosis virus reveals the acyl-enzyme complex for an intermolecular self-cleavage reaction. The Journal of Biological Chemistry. 282: 24928-37. PMID 17553791 DOI: 10.1074/Jbc.M701551200  0.512
2007 Shapova YA, Paetzel M. Crystallographic analysis of Bacillus subtilis CsaA. Acta Crystallographica. Section D, Biological Crystallography. 63: 478-85. PMID 17372352 DOI: 10.1107/S0907444907005045  0.467
2007 Ekici OD, Karla A, Paetzel M, Lively MO, Pei D, Dalbey RE. Altered -3 substrate specificity of Escherichia coli signal peptidase 1 mutants as revealed by screening a combinatorial peptide library. The Journal of Biological Chemistry. 282: 417-25. PMID 17077081 DOI: 10.1074/Jbc.M608779200  0.394
2006 Lee J, Feldman AR, Chiu E, Chan C, Kim YN, Delmas B, Paetzel M. Purification, crystallization and preliminary X-ray analysis of truncated and mutant forms of VP4 protease from infectious pancreatic necrosis virus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 1235-8. PMID 17142905 DOI: 10.1107/S1744309106046070  0.375
2006 Feldman AR, Lee J, Delmas B, Paetzel M. Crystal structure of a novel viral protease with a serine/lysine catalytic dyad mechanism. Journal of Molecular Biology. 358: 1378-89. PMID 16584747 DOI: 10.1016/J.Jmb.2006.02.045  0.465
2006 Lee J, Feldman AR, Delmas B, Paetzel M. Expression, purification and crystallization of a birnavirus-encoded protease, VP4, from blotched snakehead virus (BSNV). Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 353-6. PMID 16582483 DOI: 10.1107/S1744309106006403  0.364
2005 Karla A, Lively MO, Paetzel M, Dalbey R. The identification of residues that control signal peptidase cleavage fidelity and substrate specificity Journal of Biological Chemistry. 280: 6731-6741. PMID 15598653 DOI: 10.1074/Jbc.M413019200  0.36
2004 Paetzel M, Goodall JJ, Kania M, Dalbey RE, Page MG. Crystallographic and biophysical analysis of a bacterial signal peptidase in complex with a lipopeptide-based inhibitor. The Journal of Biological Chemistry. 279: 30781-90. PMID 15136583 DOI: 10.1074/Jbc.M401686200  0.453
2002 Paetzel M, Dalbey RE, Strynadka NC. Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism. The Journal of Biological Chemistry. 277: 9512-9. PMID 11741964 DOI: 10.1074/Jbc.M110983200  0.481
2001 Luo Y, Pfuetzner RA, Mosimann S, Paetzel M, Frey EA, Cherney M, Kim B, Little JW, Strynadka NC. Crystal structure of LexA: a conformational switch for regulation of self-cleavage. Cell. 106: 585-94. PMID 11551506 DOI: 10.1016/S0092-8674(01)00479-2  0.374
2001 White AP, Collinson SK, Banser PA, Gibson DL, Paetzel M, Strynadka NC, Kay WW. Structure and characterization of AgfB from Salmonella enteritidis thin aggregative fimbriae. Journal of Molecular Biology. 311: 735-49. PMID 11518527 DOI: 10.1006/Jmbi.2001.4876  0.389
2000 Paetzel M, Danel F, de Castro L, Mosimann SC, Page MG, Strynadka NC. Crystal structure of the class D beta-lactamase OXA-10. Nature Structural Biology. 7: 918-25. PMID 11017203 DOI: 10.1038/79688  0.406
2000 Carlos JL, Paetzel M, Brubaker G, Karla A, Ashwell CM, Lively MO, Cao G, Bullinger P, Dalbey RE. The role of the membrane-spanning domain of type I signal peptidases in substrate cleavage site selection. The Journal of Biological Chemistry. 275: 38813-22. PMID 10982814 DOI: 10.1074/Jbc.M007093200  0.451
2000 Paetzel M, Dalbey RE, Strynadka NC. The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target. Pharmacology & Therapeutics. 87: 27-49. PMID 10924740 DOI: 10.1016/S0163-7258(00)00064-4  0.462
2000 Carlos JL, Klenotic PA, Paetzel M, Strynadka NC, Dalbey RE. Mutational evidence of transition state stabilization by serine 88 in Escherichia coli type I signal peptidase. Biochemistry. 39: 7276-83. PMID 10852727 DOI: 10.1021/Bi000301L  0.389
2000 Ness S, Martin R, Kindler AM, Paetzel M, Gold M, Jensen SE, Jones JB, Strynadka NC. Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,). Biochemistry. 39: 5312-21. PMID 10820001 DOI: 10.1021/Bi992505B  0.324
2000 Klenotic PA, Carlos JL, Samuelson JC, Schuenemann TA, Tschantz WR, Paetzel M, Strynadka NC, Dalbey RE. The role of the conserved box E residues in the active site of the Escherichia coli type I signal peptidase. The Journal of Biological Chemistry. 275: 6490-8. PMID 10692453 DOI: 10.1074/Jbc.275.9.6490  0.473
1999 Paetzel M, Strynadka NCJ. Common protein architecture and binding sites in proteases utilizing a Ser/Lys dyad mechanism Protein Science. 8: 2533-2536. PMID 10595561 DOI: 10.1110/Ps.8.11.2533  0.495
1998 Paetzel M, Dalbey RE, Strynadka NC. Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor. Nature. 396: 186-90. PMID 9823901 DOI: 10.1038/24196  0.547
1998 van Klompenburg W, Paetzel M, de Jong JM, Dalbey RE, Demel RA, von Heijne G, de Kruijff B. Phosphatidylethanolamine mediates insertion of the catalytic domain of leader peptidase in membranes. Febs Letters. 431: 75-9. PMID 9684869 DOI: 10.1016/S0014-5793(98)00733-9  0.425
1998 Paetzel M, Dalbey RE, Strynadka NCJ. Erratum: Crystal structure of a bacterial signal peptidase in complex with a β-lactam inhibitor Nature. 396: 707-707. DOI: 10.1038/25403  0.425
1997 Paetzel M, Strynadka NC, Tschantz WR, Casareno R, Bullinger PR, Dalbey RE. Use of site-directed chemical modification to study an essential lysine in Escherichia coli leader peptidase. The Journal of Biological Chemistry. 272: 9994-10003. PMID 9092541 DOI: 10.1074/Jbc.272.15.9994  0.451
1997 Paetzel M, Dalbey RE. Catalytic hydroxyl/amine dyads within serine proteases. Trends in Biochemical Sciences. 22: 28-31. PMID 9020589 DOI: 10.1016/S0968-0004(96)10065-7  0.326
1995 Paetzel M, Chernaia M, Strynadka N, Tschantz W, Cao G, Dalbey RE, James MN. Crystallization of a soluble, catalytically active form of Escherichia coli leader peptidase. Proteins. 23: 122-5. PMID 8539246 DOI: 10.1002/Prot.340230115  0.439
1995 Tschantz WR, Paetzel M, Cao G, Suciu D, Inouye M, Dalbey RE. Characterization of a soluble, catalytically active form of Escherichia coli leader peptidase: requirement of detergent or phospholipid for optimal activity. Biochemistry. 34: 3935-41. PMID 7696258 DOI: 10.1021/Bi00012A010  0.481
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