Suzy V. Torti - Publications

Affiliations: 
Wake Forest University School of Medicine, Winston-Salem, NC, United States 
Area:
Biochemistry, Molecular Biology, Cell Biology

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Paul BT, Tesfay L, Winkler CR, Torti FM, Torti SV. Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes. Scientific Reports. 9: 19634. PMID 31873120 DOI: 10.1038/s41598-019-55907-z  0.52
2019 Tesfay L, Paul BT, Konstorum A, Deng Z, Cox AO, Lee J, Furdui CM, Hegde P, Torti FM, Torti SV. Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death. Cancer Research. PMID 31270077 DOI: 10.1158/0008-5472.CAN-19-0369  0.52
2019 Moghieb A, Tesfay L, Nie S, Gritsenko M, Fillmore TL, Jacobs JM, Smith RD, Torti FM, Torti SV, Shi T, Ansong C. A Targeted Mass Spectrometric Assay for Reliable Sensitive Hepcidin Quantification. Scientific Reports. 9: 7264. PMID 31086210 DOI: 10.1038/s41598-019-43756-9  0.52
2019 Torti SV, Torti FM. Winning the war with iron. Nature Nanotechnology. PMID 30911165 DOI: 10.1038/s41565-019-0419-9  0.52
2018 Torti SV, Manz DH, Paul BT, Blanchette-Farra N, Torti FM. Iron and Cancer. Annual Review of Nutrition. 38: 97-125. PMID 30130469 DOI: 10.1146/annurev-nutr-082117-051732  0.52
2018 Konstorum A, Lynch ML, Torti SV, Torti FM, Laubenbacher RC. A Systems Biology Approach to Understanding the Pathophysiology of High-Grade Serous Ovarian Cancer: Focus on Iron and Fatty Acid Metabolism. Omics : a Journal of Integrative Biology. 22: 502-513. PMID 30004845 DOI: 10.1089/omi.2018.0060  0.52
2018 Blanchette-Farra N, Kita D, Konstorum A, Tesfay L, Lemler D, Hegde P, Claffey KP, Torti FM, Torti SV. Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer. Oncogene. PMID 29695834 DOI: 10.1038/s41388-018-0243-y  0.52
2017 Deng Z, Manz DH, Torti SV, Torti FM. Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth. Oncotarget. 8: 82231-82243. PMID 29137259 DOI: 10.18632/oncotarget.19288  0.52
2017 Deng Z, Manz DH, Torti S, Torti FM. Effects of ferroportin-mediated iron depletion in cells representative of different histological subtypes of prostate cancer. Antioxidants & Redox Signaling. PMID 29061069 DOI: 10.1089/ars.2017.7023  0.52
2017 Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, ... ... Torti SV, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 171: 273-285. PMID 28985560 DOI: 10.1016/j.cell.2017.09.021  0.52
2017 Deng Z, Manz DH, Torti SV, Torti FM. Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth. Oncotarget. PMID 28751622 DOI: 10.18632/oncotarget.19288  0.52
2017 Lemler DJ, Lynch ML, Tesfay L, Deng Z, Paul BT, Wang X, Hegde P, Manz DH, Torti SV, Torti FM. DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms. Breast Cancer Research : Bcr. 19: 25. PMID 28270217 DOI: 10.1186/s13058-017-0814-9  0.52
2017 Chifman J, Arat S, Deng Z, Lemler E, Pino JC, Harris LA, Kochen MA, Lopez CF, Akman SA, Torti FM, Torti SV, Laubenbacher R. Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective. Plos Computational Biology. 13: e1005352. PMID 28166223 DOI: 10.1371/journal.pcbi.1005352  0.52
2016 Paul BT, Manz DH, Torti FM, Torti SV. Mitochondria and Iron: Current Questions. Expert Review of Hematology. PMID 27911100 DOI: 10.1080/17474086.2016.1268047  0.52
2016 Manz DH, Blanchette NL, Paul BT, Torti FM, Torti SV. Iron and cancer: recent insights. Annals of the New York Academy of Sciences. PMID 26890363 DOI: 10.1111/nyas.13008  0.52
2016 Blanchette NL, Manz DH, Torti FM, Torti SV. Modulation of hepcidin to treat iron deregulation: potential clinical applications. Expert Review of Hematology. 9: 169-86. PMID 26669208 DOI: 10.1586/17474086.2016.1124757  0.52
2015 Hatcher HC, Tesfay L, Torti SV, Torti FM. Cytoprotective Effect of Ferritin H in Renal Ischemia Reperfusion Injury. Plos One. 10: e0138505. PMID 26379029 DOI: 10.1371/journal.pone.0138505  0.52
2015 Fahrenholtz CD, Hadimani M, King SB, Torti SV, Singh R. Targeting breast cancer with sugar-coated carbon nanotubes. Nanomedicine (London, England). 10: 2481-97. PMID 26296098 DOI: 10.2217/NNM.15.90  0.52
2015 Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV. Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Research. 75: 2254-63. PMID 25858146 DOI: 10.1158/0008-5472.CAN-14-2465  0.52
2015 Chakradeo S, Sharma K, Alhaddad A, Bakhshwin D, Le N, Harada H, Nakajima W, Yeudall WA, Torti SV, Torti FM, Gewirtz DA. Yet another function of p53--the switch that determines whether radiation-induced autophagy will be cytoprotective or nonprotective: implications for autophagy inhibition as a therapeutic strategy. Molecular Pharmacology. 87: 803-14. PMID 25667224 DOI: 10.1124/mol.114.095273  0.52
2015 Swanner J, Mims J, Carroll DL, Akman SA, Furdui CM, Torti SV, Singh RN. Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells International Journal of Nanomedicine. 10: 3937-3953. DOI: 10.2147/IJN.S80349  0.52
2014 Sharma K, Goehe RW, Di X, Hicks MA, Torti SV, Torti FM, Harada H, Gewirtz DA. A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Autophagy. 10: 2346-61. PMID 25629933 DOI: 10.4161/15548627.2014.993283  0.52
2014 Chifman J, Laubenbacher R, Torti SV. A systems biology approach to iron metabolism. Advances in Experimental Medicine and Biology. 844: 201-25. PMID 25480643 DOI: 10.1007/978-1-4939-2095-2_10  0.52
2014 Basuli D, Stevens RG, Torti FM, Torti SV. Epidemiological associations between iron and cardiovascular disease and diabetes. Frontiers in Pharmacology. 5: 117. PMID 24904420 DOI: 10.3389/fphar.2014.00117  0.52
2014 Huhn AJ, Parsonage D, Horita DA, Torti FM, Torti SV, Hollis T. The high-molecular-weight kininogen domain 5 is an intrinsically unstructured protein and its interaction with ferritin is metal mediated. Protein Science : a Publication of the Protein Society. 23: 1013-22. PMID 24810540 DOI: 10.1002/pro.2486  0.52
2014 Wang W, Deng Z, Hatcher H, Miller LD, Di X, Tesfay L, Sui G, D'Agostino RB, Torti FM, Torti SV. IRP2 regulates breast tumor growth. Cancer Research. 74: 497-507. PMID 24285726 DOI: 10.1158/0008-5472.CAN-13-1224  0.52
2013 Romero-Aburto R, Narayanan TN, Nagaoka Y, Hasumura T, Mitcham TM, Fukuda T, Cox PJ, Bouchard RR, Maekawa T, Kumar DS, Torti SV, Mani SA, Ajayan PM. Fluorinated graphene oxide; a new multimodal material for biological applications. Advanced Materials (Deerfield Beach, Fla.). 25: 5632-7. PMID 24038195 DOI: 10.1002/adma201301804  0.52
2013 Singh R, Torti SV. Carbon nanotubes in hyperthermia therapy. Advanced Drug Delivery Reviews. 65: 2045-60. PMID 23933617 DOI: 10.1016/j.addr.2013.08.001  0.52
2013 Torti SV, Torti FM. Cellular iron metabolism in prognosis and therapy of breast cancer. Critical Reviews in Oncogenesis. 18: 435-48. PMID 23879588 DOI: 10.1615/CritRevOncog.2013007784  0.52
2013 Xie Z, Harrison SH, Torti SV, Torti FM, Han J. Application of circuit simulation method for differential modeling of TIM-2 iron uptake and metabolism in mouse kidney cells. Frontiers in Physiology. 4: 136. PMID 23761763 DOI: 10.3389/fphys.2013.00136  0.52
2013 Wang W, Grier DD, Woo J, Ward M, Sui G, Torti SV, Torti FM, Beaty MW. Ferritin H is a novel marker of early erythroid precursors and macrophages. Histopathology. 62: 931-40. PMID 23611361 DOI: 10.1111/his.12101  0.52
2013 Torti SV, Torti FM. Iron and cancer: more ore to be mined. Nature Reviews. Cancer. 13: 342-55. PMID 23594855 DOI: 10.1038/nrc3495  0.52
2012 Burke AR, Singh RN, Carroll DL, Torti FM, Torti SV. Targeting Cancer Stem Cells with Nanoparticle-Enabled Therapies. Journal of Molecular Biomarkers & Diagnosis. PMID 24383043 DOI: 10.4172/2155-9929.S8-003  0.52
2012 Tesfay L, Huhn AJ, Hatcher H, Torti FM, Torti SV. Ferritin blocks inhibitory effects of two-chain high molecular weight kininogen (HKa) on adhesion and survival signaling in endothelial cells. Plos One. 7: e40030. PMID 22768328 DOI: 10.1371/journal.pone.0040030  0.52
2012 Narayanan TN, Gupta BK, Vithayathil SA, Aburto RR, Mani SA, Taha-Tijerina J, Xie B, Kaipparettu BA, Torti SV, Ajayan PM. Hybrid 2D nanomaterials as dual-mode contrast agents in cellular imaging. Advanced Materials (Deerfield Beach, Fla.). 24: 2992-8. PMID 22573478 DOI: 10.1002/adma.201200706  0.52
2012 Wan M, Huang W, Kute TE, Miller LD, Zhang Q, Hatcher H, Wang J, Stovall DB, Russell GB, Cao PD, Deng Z, Wang W, Zhang Q, Lei M, Torti SV, et al. Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. The American Journal of Pathology. 180: 2120-33. PMID 22440256 DOI: 10.1016/j.ajpath.2012.01.037  0.52
2012 Chifman J, Kniss A, Neupane P, Williams I, Leung B, Deng Z, Mendes P, Hower V, Torti FM, Akman SA, Torti SV, Laubenbacher R. The core control system of intracellular iron homeostasis: a mathematical model. Journal of Theoretical Biology. 300: 91-9. PMID 22286016 DOI: 10.1016/j.jtbi.2012.01.024  0.52
2012 Burke AR, Singh RN, Carroll DL, Wood JC, D'Agostino RB, Ajayan PM, Torti FM, Torti SV. The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy. Biomaterials. 33: 2961-70. PMID 22245557 DOI: 10.1016/j.biomaterials.2011.12.052  0.52
2011 Blekherman G, Laubenbacher R, Cortes DF, Mendes P, Torti FM, Akman S, Torti SV, Shulaev V. Bioinformatics tools for cancer metabolomics. Metabolomics : Official Journal of the Metabolomic Society. 7: 329-343. PMID 21949492 DOI: 10.1007/s11306-010-0270-3  0.52
2011 Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. Plos One. 6: e23800. PMID 21886823 DOI: 10.1371/journal.pone.0023800  0.52
2011 Miller LD, Coffman LG, Chou JW, Black MA, Bergh J, D'Agostino R, Torti SV, Torti FM. An iron regulatory gene signature predicts outcome in breast cancer. Cancer Research. 71: 6728-37. PMID 21875943 DOI: 10.1158/0008-5472.CAN-11-1870  0.52
2011 Burke AR, Singh RN, Carroll DL, Owen JD, Kock ND, D'Agostino R, Torti FM, Torti SV. Determinants of the thrombogenic potential of multiwalled carbon nanotubes. Biomaterials. 32: 5970-8. PMID 21663954 DOI: 10.1016/j.biomaterials.2011.04.059  0.52
2011 Ding X, Singh R, Burke A, Hatcher H, Olson J, Kraft RA, Schmid M, Carroll D, Bourland JD, Akman S, Torti FM, Torti SV. Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy. Nanomedicine (London, England). 6: 1341-52. PMID 21506687 DOI: 10.2217/nnm.11.37  0.52
2011 Cortes DF, Sha W, Hower V, Blekherman G, Laubenbacher R, Akman S, Torti SV, Shulaev V. Differential gene expression in normal and transformed human mammary epithelial cells in response to oxidative stress. Free Radical Biology & Medicine. 50: 1565-74. PMID 21397008 DOI: 10.1016/j.freeradbiomed.2011.03.002  0.52
2011 Torti SV, Torti FM. Ironing out cancer. Cancer Research. 71: 1511-4. PMID 21363917 DOI: 10.1158/0008-5472.CAN-10-3614  0.52
2011 Clausen KA, Blish KR, Birse CE, Triplette MA, Kute TE, Russell GB, D'Agostino RB, Miller LD, Torti FM, Torti SV. SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer. Breast Cancer Research and Treatment. 129: 737-46. PMID 21113658 DOI: 10.1007/s10549-010-1261-9  0.52
2010 Fisher JW, Sarkar S, Buchanan CF, Szot CS, Whitney J, Hatcher HC, Torti SV, Rylander CG, Rylander MN. Photothermal response of human and murine cancer cells to multiwalled carbon nanotubes after laser irradiation. Cancer Research. 70: 9855-64. PMID 21098701 DOI: 10.1158/0008-5472.CAN-10-0250  0.52
2010 Blish KR, Clausen KA, Hawkins GA, Garvin AJ, Willingham MC, Turner JC, Torti FM, Torti SV. Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors. Journal of Experimental & Clinical Cancer Research : Cr. 29: 147. PMID 21080955 DOI: 10.1186/1756-9966-29-147  0.52
2010 Pinnix ZK, Miller LD, Wang W, D'Agostino R, Kute T, Willingham MC, Hatcher H, Tesfay L, Sui G, Di X, Torti SV, Torti FM. Ferroportin and iron regulation in breast cancer progression and prognosis. Science Translational Medicine. 2: 43ra56. PMID 20686179 DOI: 10.1126/scisignal.3001127  0.52
2010 Wang W, Di X, Torti SV, Torti FM. Ferritin H induction by histone deacetylase inhibitors. Biochemical Pharmacology. 80: 316-24. PMID 20385107 DOI: 10.1016/j.bcp.2010.04.008  0.52
2010 Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: Past, present and future. Biochimica Et Biophysica Acta. 1800: 760-9. PMID 20304033 DOI: 10.1016/j.bbagen.2010.03.011  0.52
2010 Neal RE, Singh R, Hatcher HC, Kock ND, Torti SV, Davalos RV. Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode. Breast Cancer Research and Treatment. 123: 295-301. PMID 20191380 DOI: 10.1007/s10549-010-0803-5  0.52
2010 Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1 Proceedings of the National Academy of Sciences of the United States of America. 107: 3505-3510. PMID 20133674 DOI: 10.1073/pnas.0913192107  0.52
2009 Hatcher HC, Singh RN, Torti FM, Torti SV. Synthetic and natural iron chelators: therapeutic potential and clinical use. Future Medicinal Chemistry. 1: 1643-70. PMID 21425984 DOI: 10.4155/fmc.09.121  0.52
2009 Ying M, Smentek MG, Ma R, Day CS, Torti SV, Welker ME. Preparation of Disubstituted Phenyl Propargyl Alcohols, their Use in Oxathiolene Oxide Synthesis, and Evaluation of the Oxathiolene Oxide Products as Anticarcinogenic Enzyme Inducers. Letters in Organic Chemistry. 6: 242-251. PMID 19865593 DOI: 10.2174/157017809787893064  0.52
2009 Storey JA, Connor RF, Lewis ZT, Hurd D, Pomper G, Keung YK, Grover M, Lovato J, Torti SV, Torti FM, Molnár I. The transplant iron score as a predictor of stem cell transplant survival. Journal of Hematology & Oncology. 2: 44. PMID 19852846 DOI: 10.1186/1756-8722-2-44  0.52
2009 Burke A, Ding X, Singh R, Kraft RA, Levi-Polyachenko N, Rylander MN, Szot C, Buchanan C, Whitney J, Fisher J, Hatcher HC, D'Agostino R, Kock ND, Ajayan PM, Carroll DL, ... ... Torti SV, et al. Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation. Proceedings of the National Academy of Sciences of the United States of America. 106: 12897-902. PMID 19620717 DOI: 10.1073/pnas.0905195106  0.52
2009 Laubenbacher R, Hower V, Jarrah A, Torti SV, Shulaev V, Mendes P, Torti FM, Akman S. A systems biology view of cancer. Biochimica Et Biophysica Acta. 1796: 129-39. PMID 19505535 DOI: 10.1016/j.bbcan.2009.06.001  0.52
2009 Hower V, Mendes P, Torti FM, Laubenbacher R, Akman S, Shulaev V, Torti SV. A general map of iron metabolism and tissue-specific subnetworks. Molecular Biosystems. 5: 422-43. PMID 19381358 DOI: 10.1039/b816714c  0.52
2009 Turk T, Leeuwis JW, Gray J, Torti SV, Lyons KM, Nguyen TQ, Goldschmeding R. BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 57: 623-31. PMID 19255250 DOI: 10.1369/jhc.2009.953224  0.52
2009 Coffman LG, Parsonage D, D'Agostino R, Torti FM, Torti SV. Regulatory effects of ferritin on angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 570-5. PMID 19126685 DOI: 10.1073/pnas.0812010106  0.52
2009 Knovich MA, Storey JA, Coffman LG, Torti SV, Torti FM. Ferritin for the clinician. Blood Reviews. 23: 95-104. PMID 18835072 DOI: 10.1016/j.blre.2008.08.001  0.52
2009 Jiao Y, Wilkinson J, Di X, Wang W, Hatcher H, Kock ND, D'Agostino R, Knovich MA, Torti FM, Torti SV. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood. 113: 462-9. PMID 18815282 DOI: 10.1182/blood-2008-05-155952  0.52
2008 Zhang F, Wang W, Tsuji Y, Torti SV, Torti FM. Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest. The Journal of Biological Chemistry. 283: 33911-8. PMID 18819919 DOI: 10.1074/jbc.M806432200  0.52
2008 Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: From ancient medicine to current clinical trials Cellular and Molecular Life Sciences. 65: 1631-1652. PMID 18324353 DOI: 10.1007/s00018-008-7452-4  0.52
2008 Coffman LG, Brown JC, Johnson DA, Parthasarathy N, D'Agostino RB, Lively MO, Hua X, Tilley SL, Muller-Esterl W, Willingham MC, Torti FM, Torti SV. Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L505-15. PMID 18192590 DOI: 10.1152/ajplung.00347.2007  0.52
2008 Blish KR, Wang W, Willingham MC, Du W, Birse CE, Krishnan SR, Brown JC, Hawkins GA, Garvin AJ, D'Agostino RB, Torti FM, Torti SV. A human bone morphogenetic protein antagonist is down-regulated in renal cancer. Molecular Biology of the Cell. 19: 457-64. PMID 18032587 DOI: 10.1091/mbc.E07-05-0433  0.52
2008 Childers ML, Cho J, Regino CA, Brechbiel MW, DiPasquale AG, Rheingold AL, Torti SV, Torti FM, Planalp RP. Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators. Journal of Inorganic Biochemistry. 102: 150-6. PMID 17900698 DOI: 10.1016/j.jinorgbio.2007.07.039  0.52
2007 Torti SV, Byrne F, Whelan O, Levi N, Ucer B, Schmid M, Torti FM, Akman S, Liu J, Ajayan PM, Nalamasu O, Carroll DL. Thermal ablation therapeutics based on CN(x) multi-walled nanotubes. International Journal of Nanomedicine. 2: 707-14. PMID 18203437  0.52
2007 Wang W, Di X, D'Agostino RB, Torti SV, Torti FM. Excess capacity of the iron regulatory protein system. The Journal of Biological Chemistry. 282: 24650-9. PMID 17604281 DOI: 10.1074/jbc.M703167200  0.52
2006 Jennings-Gee JE, Tsuji Y, Pietsch EC, Moran E, Mymryk JS, Torti FM, Torti SV. Coordinate inhibition of cytokine-mediated induction of ferritin H, manganese superoxide dismutase, and interleukin-6 by the adenovirus E1A oncogene. The Journal of Biological Chemistry. 281: 16428-35. PMID 16611629 DOI: 10.1074/jbc.M600038200  0.52
2006 Jiao Y, Wilkinson J, Christine Pietsch E, Buss JL, Wang W, Planalp R, Torti FM, Torti SV. Iron chelation in the biological activity of curcumin. Free Radical Biology & Medicine. 40: 1152-60. PMID 16545682 DOI: 10.1016/j.freeradbiomed.2005.11.003  0.52
2006 Wilkinson J, Di X, Schönig K, Buss JL, Kock ND, Cline JM, Saunders TL, Bujard H, Torti SV, Torti FM. Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo. The Biochemical Journal. 395: 501-7. PMID 16448386 DOI: 10.1042/BJ20060063  0.52
2005 Regino CA, Torti SV, Ma R, Yap GP, Kreisel KA, Torti FM, Planalp RP, Brechbiel MW. N-picolyl derivatives of Kemp's triamine as potential antitumor agents: a preliminary investigation. Journal of Medicinal Chemistry. 48: 7993-9. PMID 16335923 DOI: 10.1021/jm050724r  0.52
2005 Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. The Journal of Experimental Medicine. 202: 955-65. PMID 16203866 DOI: 10.1084/jem.20042433  0.52
2005 Torti SV, Ma R, Venditto VJ, Torti FM, Planalp RP, Brechbiel MW. Preliminary evaluation of the cytotoxicity of a series of tris-2-aminoethylamine (Tren) based hexadentate heterocyclic donor agents. Bioorganic & Medicinal Chemistry. 13: 5961-7. PMID 16115775 DOI: 10.1016/j.bmc.2005.07.007  0.52
2005 Turner J, Koumenis C, Kute TE, Planalp RP, Brechbiel MW, Beardsley D, Cody B, Brown KD, Torti FM, Torti SV. Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation. Blood. 106: 3191-9. PMID 16014567 DOI: 10.1182/blood-2005-03-1263  0.52
2005 Alexander RL, Greene BT, Torti SV, Kucera GL. A novel phospholipid gemcitabine conjugate is able to bypass three drug-resistance mechanisms. Cancer Chemotherapy and Pharmacology. 56: 15-21. PMID 15789226 DOI: 10.1007/s00280-004-0949-0  0.52
2005 Franks MA, Schrader EA, Pietsch EC, Pennella DR, Torti SV, Welker ME. Oxathiolene oxide synthesis via chelation-controlled addition of organometallic reagents to alkynols followed by addition of sulfur electrophiles and evaluation of oxathiolene oxides as anticarcinogenic enzyme inducers. Bioorganic & Medicinal Chemistry. 13: 2221-33. PMID 15727874 DOI: 10.1016/j.bmc.2004.12.037  0.52
2005 Childers ML, Su F, Przyborowska AM, Bishwokarma B, Park G, Brechbiel MW, Torti SV, Torti FM, Broker G, Alexander JS, Rogers RD, Ruhlandt-Senge K, Planalp RP. Pyridine-ring alkylation of cytotoxic r-1,c-3,c-5-tris[(2-pyridylmethyl)- amino]cyclohexane chelators: Structural and electronic properties of the Mn II, FeII, NiII, CuII and Zn II complexes European Journal of Inorganic Chemistry. 3971-3982. DOI: 10.1002/ejic.200500382  0.52
2004 Buss JL, Greene BT, Turner J, Torti FM, Torti SV. Iron chelators in cancer chemotherapy. Current Topics in Medicinal Chemistry. 4: 1623-35. PMID 15579100 DOI: 10.2174/1568026043387269  0.52
2004 Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, Jayawardena S, De Smaele E, Cong R, Beaumont C, Torti FM, Torti SV, Franzoso G. Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell. 119: 529-42. PMID 15537542 DOI: 10.1016/j.cell.2004.10.017  0.52
2004 Chong HS, Torti SV, Ma R, Torti FM, Brechbiel MW. Synthesis and potent antitumor activities of novel 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives. Journal of Medicinal Chemistry. 47: 5230-4. PMID 15456266 DOI: 10.1021/jm040076w  0.52
2004 Ye N, Park G, Przyborowska AM, Sloan PE, Clifford T, Bauer CB, Broker GA, Rogers RD, Ma R, Torti SV, Brechbiel MW, Planalp RP. Nickel(II), copper(II) and zinc(II) binding properties and cytotoxicity of tripodal, hexadentate tris(ethylenediamine)--analogue chelators. Dalton Transactions (Cambridge, England : 2003). 1304-11. PMID 15252622 DOI: 10.1039/b403476g  0.52
2004 Zhao R, Planalp RP, Ma R, Greene BT, Jones BT, Brechbiel MW, Torti FM, Torti SV. Role of zinc and iron chelation in apoptosis mediated by tachpyridine, an anti-cancer iron chelator. Biochemical Pharmacology. 67: 1677-88. PMID 15081867 DOI: 10.1016/j.bcp.2003.12.036  0.52
2003 Wilkinson J, Pietsch EC, Torti SV, Torti FM. Ferritin regulation by oxidants and chemopreventive xenobiotics. Advances in Enzyme Regulation. 43: 135-51. PMID 12791388 DOI: 10.1016/S0065-2571(02)00037-7  0.52
2003 Pietsch EC, Hurley AL, Scott EE, Duckworth BP, Welker ME, Leone-Kabler S, Townsend AJ, Torti FM, Torti SV. Oxathiolene oxides: a novel family of compounds that induce ferritin, glutathione S-transferase, and other proteins of the phase II response. Biochemical Pharmacology. 65: 1261-9. PMID 12694867 DOI: 10.1016/S0006-2952(03)00081-9  0.52
2003 Buss JL, Torti FM, Torti SV. The role of iron chelation in cancer therapy. Current Medicinal Chemistry. 10: 1021-34. PMID 12678674 DOI: 10.2174/0929867033457638  0.52
2003 Thompson K, Menzies S, Muckenthaler M, Torti FM, Wood T, Torti SV, Hentze MW, Beard J, Connor J. Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. Journal of Neuroscience Research. 71: 46-63. PMID 12478613 DOI: 10.1002/jnr.10463  0.52
2003 Pietsch EC, Chan JY, Torti FM, Torti SV. Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones. The Journal of Biological Chemistry. 278: 2361-9. PMID 12435735 DOI: 10.1074/jbc.M210664200  0.52
2002 Chong HS, Torti FM, Torti SV, Brechbiel MW. Synthesis of 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives as potential antitumor agents. The Journal of Organic Chemistry. 67: 8072-8. PMID 12423134 DOI: 10.1021/jo0204911  0.52
2002 Planalp RP, Przyborowska AM, Park G, Ye N, Lu FH, Rogers RD, Broker GA, Torti SV, Brechbiel MW. Novel cytotoxic chelators that bind iron(II) selectively over zinc(II) under aqueous aerobic conditions. Biochemical Society Transactions. 30: 758-62. PMID 12196188 DOI: 10.1042/  0.52
2002 Parthasarathy N, Torti SV, Torti FM. Ferritin binds to light chain of human H-kininogen and inhibits kallikrein-mediated bradykinin release. The Biochemical Journal. 365: 279-86. PMID 12071855 DOI: 10.1042/BJ20011637  0.52
2002 Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood. 99: 3505-16. PMID 11986201 DOI: 10.1182/blood.V99.10.3505  0.52
2002 Greene BT, Thorburn J, Willingham MC, Thorburn A, Planalp RP, Brechbiel MW, Jennings-Gee J, Wilkinson J, Torti FM, Torti SV. Activation of caspase pathways during iron chelator-mediated apoptosis. The Journal of Biological Chemistry. 277: 25568-75. PMID 11980894 DOI: 10.1074/jbc.M110345200  0.52
2002 Torti SV, Golden-Fleet M, Willingham MC, Ma R, Cline M, Sakimoto Y, Torti FM. Use of green fluorescent protein to measure tumor growth in an implanted bladder tumor model. The Journal of Urology. 167: 724-8. PMID 11792961  0.52
2001 Abeysinghe RD, Greene BT, Haynes R, Willingham MC, Turner J, Planalp RP, Brechbiel MW, Torti FM, Torti SV. p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator. Carcinogenesis. 22: 1607-14. PMID 11576999  0.52
2001 Orino K, Lehman L, Tsuji Y, Ayaki H, Torti SV, Torti FM. Ferritin and the response to oxidative stress. The Biochemical Journal. 357: 241-7. PMID 11415455 DOI: 10.1042/0264-6021:3570241  0.52
2000 Tsuji Y, Ayaki H, Whitman SP, Morrow CS, Torti SV, Torti FM. Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress Molecular and Cellular Biology. 20: 5818-5827. PMID 10913165 DOI: 10.1128/MCB.20.16.5818-5827.2000  0.52
1999 Orino K, Tsuji Y, Torti FM, Torti SV. Adenovirus E1A blocks oxidant-dependent ferritin induction and sensitizes cells to pro-oxidant cytotoxicity Febs Letters. 461: 334-338. PMID 10567722 DOI: 10.1016/S0014-5793(99)01443-X  0.52
1999 Tsuji Y, Moran E, Torti SV, Torti M. Transcriptional regulation of the mouse ferritin H gene: Involvement of p300/CBP adaptor proteins in FER-1 enhancer activity Journal of Biological Chemistry. 274: 7501-7507. PMID 10066817 DOI: 10.1074/jbc.274.11.7501  0.52
1998 Torti SV, Torti FM, Whitman SP, Brechbiel MW, Park G, Planalp RP. Tumor cell cytotoxicity of a novel metal chelator. Blood. 92: 1384-9. PMID 9694727  0.52
1998 Torti SV, Akimoto H, Lin K, Billingham ME, Torti FM. Selective inhibition of muscle gene expression by oxidative stress in cardiac cells Journal of Molecular and Cellular Cardiology. 30: 1173-1180. PMID 9689591 DOI: 10.1006/jmcc.1998.0681  0.52
1998 Torti SV, Torti FM. Human H-kininogen is a ferritin-binding protein Journal of Biological Chemistry. 273: 13630-13635. PMID 9593701 DOI: 10.1074/jbc.273.22.13630  0.52
1998 Tsuji Y, Torti SV, Torti FM. Activation of the ferritin H enhancer, FER-1, by the cooperative action of members of the AP1 and SP1 transcription factor families Journal of Biological Chemistry. 273: 2984-2992. PMID 9446612 DOI: 10.1074/jbc.273.5.2984  0.52
1998 Park G, Lu FH, Ye N, Brechbiel MW, Torti SV, Torti FM, Planalp RP. Novel iron complexes and chelators based on cis, cis-1,3,5- triaminocyclohexane: Iron-mediated ligand oxidation and biochemical properties Journal of Biological Inorganic Chemistry. 3: 449-457. DOI: 10.1007/s007750050254  0.52
1997 Rucker P, Torti FM, Torti SV. Recombinant ferritin: Modulation of subunit stoichiometry in bacterial expression systems Protein Engineering. 10: 967-973. PMID 9415447  0.52
1996 Rucker P, Torti FM, Torti SV. Role of H and L subunits in mouse ferritin Journal of Biological Chemistry. 271: 33352-33357. PMID 8969195 DOI: 10.1074/jbc.271.52.33352  0.52
1996 Beaumont C, Torti SV, Torti FM, Massover WH. Novel properties of L-type polypeptide subimits in mouse ferritin molecules Journal of Biological Chemistry. 271: 7923-7926. PMID 8626471  0.52
1995 Kwak EL, Larochelle DA, Beaumont C, Torti SV, Torti FM. Role for NF-kappa B in the regulation of ferritin H by tumor necrosis factor-alpha. The Journal of Biological Chemistry. 270: 15285-93. PMID 7797515 DOI: 10.1074/jbc.270.25.15285  0.52
1995 Tsuji Y, Akebi N, Lam TK, Nakabeppu Y, Torti SV, Torti FM. FER-1, an enhancer of the ferritin H gene and a target of E1A-mediated transcriptional repression Molecular and Cellular Biology. 15: 5152-5164. PMID 7651432  0.52
1994 Torti SV, Torti FM. Iron and ferritin in inflammation and cancer Advances in Inorganic Biochemistry. 10: 119-137. PMID 8203285  0.52
1994 Torti FM, Torti SV. Cytokines, iron homeostasis, and cancer Advances in Experimental Medicine and Biology. 354: 161-170. PMID 8067284  0.52
1993 Tsuji Y, Kwak E, Saika T, Torti SV, Torti FM. Preferential repression of the H subunit of ferritin by adenovirus E1A in NIH-3T3 mouse fibroblasts Journal of Biological Chemistry. 268: 7270-7275. PMID 8463262  0.52
1993 Tsuji Y, Ninomiya-Tsuji J, Torti SV, Torti FM. Augmentation by IL-1α of tumor necrosis factor-α cytotoxicity in cells transfected with adenovirus E1A Journal of Immunology. 150: 1897-1907. PMID 8436824  0.52
1993 Akimoto H, Bruno NA, Slate DL, Billingham ME, Torti SV, Torti FM. Effect of verapamil on doxorubicin cardiotoxicity: altered muscle gene expression in cultured neonatal rat cardiomyocytes. Cancer Research. 53: 4658-64. PMID 8402643  0.52
1993 Schröder H, Warren S, Bargetzi MJ, Torti SV, Torti FM. N-acetyl-L-cysteine protects endothelial cells but not L929 tumor cells from tumor necrosis factor-α-mediated cytotoxicity Naunyn-Schmiedeberg's Archives of Pharmacology. 347: 664-666. PMID 8361551 DOI: 10.1007/BF00166951  0.52
1993 Warren S, Torti SV, Torti FM. The role of iron in the cytotoxicity of tumor necrosis factor Lymphokine and Cytokine Research. 12: 75-80. PMID 8324080  0.52
1993 Tsuji Y, Ninomiya-Tsuji J, Torti SV, Torti FM. Selective loss of CDC2 and CDK2 induction by tumor necrosis factor-α in senescent human diploid fibroblasts Experimental Cell Research. 209: 175-182. PMID 8262134  0.52
1991 Miller LL, Miller SC, Torti SV, Tsuji Y, Torti FM. Iron-independent induction of ferritin H chain by tumor necrosis factor Proceedings of the National Academy of Sciences of the United States of America. 88: 4946-4950. PMID 2052577  0.52
1991 Tsuji Y, Miller LL, Miller SC, Torti SV, Torti FM. Tumor necrosis factor-α and interleukin 1-α regulate transferrin receptor in human diploid fibroblasts: Relationship to the induction of ferritin heavy chain Journal of Biological Chemistry. 266: 7257-7261. PMID 2016326  0.52
1991 Ito H, Miller SC, Akimoto H, Torti SV, Taylor A, Billingham ME, Torti FM. Evaluation of mRNA levels by the polymerase chain reaction in small cardiac tissue samples Journal of Molecular and Cellular Cardiology. 23: 1117-1125. PMID 1749003 DOI: 10.1016/0022-2828(91)90201-V  0.52
1990 Wei Y, Miller SC, Tsuji Y, Torti SV, Torti FM. Interleukin 1 induces ferritin heavy chain in human muscle cells Biochemical and Biophysical Research Communications. 169: 289-296. PMID 2350350 DOI: 10.1016/0006-291X(90)91466-6  0.52
1990 Ito H, Miller SC, Billingham ME, Akimoto H, Torti SV, Wade R, Gahlmann R, Lyons G, Kedes L, Torti FM. Dexorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitro Proceedings of the National Academy of Sciences of the United States of America. 87: 4275-4279. PMID 2349236  0.52
1990 Kwak EL, Torti SV, Torti FM. Murine ferritin heavy chain: isolation and characterization of a functional gene Gene. 94: 255-261. PMID 2258056 DOI: 10.1016/0378-1119(90)90396-9  0.52
1989 Torti FM, Torti SV, Larrick JW, Ringold GM. Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor beta Journal of Cell Biology. 108: 1105-1113. PMID 2921280  0.52
1988 Torti SV, Kwak EL, Miller SC, Miller LL, Ringold GM, Myambo KB, Young AP, Torti FM. The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene Journal of Biological Chemistry. 263: 12638-12644. PMID 3410854  0.52
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