Aloke Dutta - Publications

Affiliations: 
Pharmaceutical Sciences Wayne State University, Detroit, MI, United States 
Area:
Pharmaceutical Chemistry

85 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Dutta AK, Santra S, Harutyunyan A, Das B, Michael Lisieski, Xu L, Antonio T, Reith MEA, Perrine SA. D-578, an orally active triple monoamine reuptake inhibitor, displays antidepressant and anti-PTSD effects in rats. European Journal of Pharmacology. 172632. PMID 31473161 DOI: 10.1016/j.ejphar.2019.172632  0.56
2018 Elmabruk A, Das B, Yedlapudi D, Xu L, Antonio T, Reith MEA, Dutta AK. Design, Synthesis and Pharmacological Characterization of Carbazole Based Dopamine Agonists as Potential Symptomatic and Neuroprotective Therapeutic Agents for Parkinson's Disease. Acs Chemical Neuroscience. PMID 30301349 DOI: 10.1021/acschemneuro.8b00291  0.56
2017 Singh SK, Dutta A, Modi G. α-Synuclein aggregation modulation: an emerging approach for the treatment of Parkinson's disease. Future Medicinal Chemistry. PMID 28632413 DOI: 10.4155/fmc-2017-0016  0.36
2017 Das B, Kandegedara A, Xu L, Antonio T, Stemmler T, Reith MEA, Dutta AK. A Novel Iron(II) Preferring Dopamine Agonist Chelator as Potential Symptomatic and Neuroprotective Therapeutic Agent for Parkinson's Disease. Acs Chemical Neuroscience. 8: 723-730. PMID 28106982 DOI: 10.1021/acschemneuro.6b00356  0.56
2016 Luo D, Sharma H, Yedlapudi D, Antonio T, Reith MEA, Dutta AK. Novel multifunctional dopamine D2/D3 receptors agonists with potential neuroprotection and anti-alpha synuclein protein aggregation properties. Bioorganic & Medicinal Chemistry. 24: 5088-5102. PMID 27591013 DOI: 10.1016/j.bmc.2016.08.021  0.56
2016 Dutta A, Ghosh SK. Skin-coloured papules and nodules in an infant. Journal of Paediatrics and Child Health. 52: 680. PMID 27333854 DOI: 10.1111/jpc.13010  0.4
2016 Dholkawala F, Voshavar C, Dutta AK. Synthesis and characterization of brain penetrant prodrug of neuroprotective D-264: Potential therapeutic application in the treatment of Parkinson's disease. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 103: 62-70. PMID 26994936 DOI: 10.1016/j.ejpb.2016.03.017  0.32
2016 Dutta A, Ghosh SK, Ghosh A, Roy S. A 5-year Journey with Cutis Laxa in an Indian Child: The De Barsy Syndrome Revisited. Indian Journal of Dermatology. 61: 81-4. PMID 26955101 DOI: 10.4103/0019-5154.174031  0.4
2016 Nag SS, Dutta A, Mandal RK. Delayed Cutaneous Findings of Hand, Foot, and Mouth Disease. Indian Pediatrics. 53: 42-4. PMID 26840671  0.4
2016 Zhen J, Antonio T, Jacob JC, Grandy DK, Reith MEA, Dutta AK, Selley DE. Efficacy of Hybrid Tetrahydrobenzo[d]thiazole Based Aryl Piperazines D-264 and D-301 at D₂ and D₃ Receptors. Neurochemical Research. 41: 328-339. PMID 26718829 DOI: 10.1007/s11064-015-1808-6  0.56
2016 Baqui AH, Mitra DK, Begum N, Hurt L, Soremekun S, Edmond K, Kirkwood B, Bhandari N, Taneja S, Mazumder S, Nisar MI, Jehan F, Ilyas M, Ali M, Ahmed I, ... ... Dutta A, et al. Neonatal mortality within 24 hours of birth in six low-and lower-middle-income countries Bulletin of the World Health Organization. 94: 752-758B. DOI: 10.2471/BLT.15.160945  0.4
2016 Biswas S, Dolai M, Dutta A, Ali M. Synthesis, structural characterization and DFT calculation on a square-planar Ni(II) complex of a compartmental Schiff base ligand Journal of Molecular Structure. 1125: 688-695. DOI: 10.1016/j.molstruc.2016.07.059  0.4
2016 Dutta AK, Biswas S, Dutta S, Dawe LN, Lucas CR, Adhikary B. Syntheses, structural, spectroscopic and magnetic properties of polynuclear Fe(III) complexes containing N and O donor ligands Inorganica Chimica Acta. 444: 141-149. DOI: 10.1016/j.ica.2016.01.036  0.8
2016 Dutta A, Ghosh SK, Kumar KJ, Ramaswamy S. Images Indian Pediatrics. 53: 757. DOI: 10.1007/s13312-016-0927-8  0.4
2015 Sharma H, Santra S, Dutta A. Triple reuptake inhibitors as potential next-generation antidepressants: a new hope? Future Medicinal Chemistry. PMID 26619226 DOI: 10.4155/fmc.15.134  0.32
2015 Das B, Vedachalam S, Luo D, Antonio T, Reith ME, Dutta AK. Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson's Disease. Journal of Medicinal Chemistry. 58: 9179-95. PMID 26555041 DOI: 10.1021/acs.jmedchem.5b01031  0.8
2015 Biswas S, Dutta A, Dolai M, Bhowmick I, Rouzières M, Clérac R, Panja A, Ali M. Novel Cu(II)-M(II)-Cu(II) (M = Cu or Ni) trinuclear and [NaCu] hexanuclear complexes assembled by bi-compartmental ligands: syntheses, structures, magnetic and catalytic studies. Dalton Transactions (Cambridge, England : 2003). 44: 9426-38. PMID 25915730 DOI: 10.1039/c4dt03728f  0.4
2015 Zhen J, Antonio T, Ali S, Neve KA, Dutta AK, Reith ME. Use of radiolabeled antagonist assays for assessing agonism at D2 and D3 dopamine receptors: comparison with functional GTPγS assays. Journal of Neuroscience Methods. 248: 7-15. PMID 25840364 DOI: 10.1016/j.jneumeth.2015.03.028  0.8
2015 Das B, Modi G, Dutta A. Dopamine D3 agonists in the treatment of Parkinson's disease. Current Topics in Medicinal Chemistry. 15: 908-26. PMID 25832718  0.36
2015 Santra S, Sharma H, Vedachalam S, Antonio T, Reith M, Dutta A. Development of potent dopamine-norepinephrine uptake inhibitors (DNRIs) based on a (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol molecular template. Bioorganic & Medicinal Chemistry. 23: 821-8. PMID 25593099 DOI: 10.1016/j.bmc.2014.12.040  0.32
2015 Voshavar C, Shah M, Xu L, Dutta AK. Assessment of Protective Role of Multifunctional Dopamine Agonist D-512 Against Oxidative Stress Produced by Depletion of Glutathione in PC12 Cells: Implication in Neuroprotective Therapy for Parkinson’s Disease Neurotoxicity Research. DOI: 10.1007/s12640-015-9548-6  0.32
2014 Dutta AK, Santra S, Sharma H, Voshavar C, Xu L, Mabrouk O, Antonio T, Reith ME. Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters. Plos One. 9: e113420. PMID 25427177 DOI: 10.1371/journal.pone.0113420  0.8
2014 Modi G, Sharma H, Kharkar PS, Dutta AK. Understanding the Structural Requirements of Hybrid (S)-6-((2-(4-Phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol and its Analogs as D2/D3 Receptor Ligands: A Three-Dimensional Quantitative Structure-Activity Relationship (3D QSAR) Investigation. Medchemcomm. 5: 1384-1399. PMID 25221669 DOI: 10.1039/C4MD00159A  0.32
2014 Modi G, Voshavar C, Gogoi S, Shah M, Antonio T, Reith ME, Dutta AK. Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregates. Acs Chemical Neuroscience. 5: 700-17. PMID 24960209 DOI: 10.1021/cn500084x  0.8
2014 Shah M, Rajagopalan S, Xu L, Voshavar C, Shurubor Y, Beal F, Andersen JK, Dutta AK. The high-affinity D2/D3 agonist D512 protects PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of Parkinson's disease. Journal of Neurochemistry. 131: 74-85. PMID 24848702 DOI: 10.1111/jnc.12767  0.32
2014 Modi G, Antonio T, Reith M, Dutta A. Structural modifications of neuroprotective anti-Parkinsonian (-)-N6-(2-(4-(biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): an effort toward the improvement of in vivo efficacy of the parent molecule. Journal of Medicinal Chemistry. 57: 1557-72. PMID 24471976 DOI: 10.1021/jm401883v  0.32
2014 Sharma H, Santra S, Debnath J, Antonio T, Reith M, Dutta A. Flexible and biomimetic analogs of triple uptake inhibitor 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: Synthesis, biological characterization, and development of a pharmacophore model. Bioorganic & Medicinal Chemistry. 22: 311-24. PMID 24315194 DOI: 10.1016/j.bmc.2013.11.017  0.32
2013 Biswas S, Dutta A, Debnath M, Dolai M, Das KK, Ali M. A novel thermally stable hydroperoxo-copper(II) complex in a Cu(N2O2) chromophore of a potential N4O2 donor Schiff base ligand: synthesis, structure and catalytic studies. Dalton Transactions (Cambridge, England : 2003). 42: 13210-9. PMID 23884097 DOI: 10.1039/c3dt51359a  0.8
2013 Gopishetty B, Zhang S, Kharkar PS, Antonio T, Reith M, Dutta AK. Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors. Bioorganic & Medicinal Chemistry. 21: 3164-74. PMID 23623679 DOI: 10.1016/j.bmc.2013.03.059  0.32
2013 Johnson M, Antonio T, Reith ME, Dutta AK. Correction to Structure-Activity Relationship Study of N(6)-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N(6)-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Development of Highly Selective D3 Dopamine Receptor Agonists along with a Highly Potent D2/D3 Agonist and Their Pharmacological Characterization. Journal of Medicinal Chemistry. 56: 589-90. PMID 23289730 DOI: 10.1021/jm301634c  0.8
2013 Kuzhikandathil EV, Cote S, Santra S, Dutta AK. Interaction of D₃ preferring agonist (-)-N⁶-(2-(4-(biphenyl-4-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264) with cloned human Dâ‚‚L, Dâ‚‚S, and D₃ receptors: potent stimulation of mitogen-activated protein kinases and G protein-coupled inward rectifier potassium channels. Naunyn-Schmiedeberg's Archives of Pharmacology. 386: 97-105. PMID 23160988 DOI: 10.1007/s00210-012-0811-6  0.32
2012 Gogoi S, Biswas S, Modi G, Antonio T, Reith ME, Dutta AK. Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. Acs Medicinal Chemistry Letters. 3: 991-996. PMID 23275802 DOI: 10.1021/ml3002117  0.8
2012 Santra S, Gogoi S, Gopishetty B, Antonio T, Zhen J, Reith ME, Dutta AK. Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants. Chemmedchem. 7: 2093-100. PMID 23060293 DOI: 10.1002/cmdc.201200352  0.8
2012 Johnson M, Antonio T, Reith ME, Dutta AK. Structure-activity relationship study of N⁶-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterization. Journal of Medicinal Chemistry. 55: 5826-40. PMID 22642365 DOI: 10.1021/jm300268s  0.8
2012 Zhen J, Ali S, Dutta AK, Reith ME. Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive. Journal of Neuroscience Methods. 203: 19-27. PMID 21933682 DOI: 10.1016/j.jneumeth.2011.08.044  0.8
2011 Dutta AK, Gopishetty B, Gogoi S, Ali S, Zhen J, Reith M. The novel trisubstituted pyran derivative D-142 has triple monoamine reuptake inhibitory activity and exerts potent antidepressant-like activity in rodents. European Journal of Pharmacology. 671: 39-44. PMID 21963455 DOI: 10.1016/j.ejphar.2011.09.162  0.44
2011 Gopishetty B, Gogoi S, Dutta A. An improved asymmetric synthetic route to a novel triple uptake inhibitor antidepressant (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol (D-142). Tetrahedron, Asymmetry. 22: 1081-1086. PMID 21927543 DOI: 10.1016/j.tetasy.2011.05.012  0.36
2011 Gogoi S, Antonio T, Rajagopalan S, Reith M, Andersen J, Dutta AK. Dopamine D₂/D₃ agonists with potent iron chelation, antioxidant and neuroprotective properties: potential implication in symptomatic and neuroprotective treatment of Parkinson's disease. Chemmedchem. 6: 991-5. PMID 21567969 DOI: 10.1002/cmdc.201100140  0.32
2011 Gopishetty B, Hazeldine S, Santra S, Johnson M, Modi G, Ali S, Zhen J, Reith M, Dutta A. Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. Journal of Medicinal Chemistry. 54: 2924-32. PMID 21446715 DOI: 10.1021/jm200020a  0.6
2011 Kortagere S, Cheng SY, Antonio T, Zhen J, Reith ME, Dutta AK. Interaction of novel hybrid compounds with the D3 dopamine receptor: Site-directed mutagenesis and homology modeling studies. Biochemical Pharmacology. 81: 157-63. PMID 20833147 DOI: 10.1016/j.bcp.2010.08.026  0.8
2010 Batman AM, Dutta AK, Reith ME, Beardsley PM. The selective dopamine uptake inhibitor, D-84, suppresses cocaine self-administration, but does not occasion cocaine-like levels of generalization. European Journal of Pharmacology. 648: 127-32. PMID 20840845 DOI: 10.1016/j.ejphar.2010.08.051  0.8
2010 Ghosh SK, Bandyopadhyay D, Ghosh A, Dutta A, Biswas S, Mandal RK, Jamadar NS. Mucocutaneous features of hand, foot, and mouth disease: a reappraisal from an outbreak in the city of Kolkata. Indian Journal of Dermatology, Venereology and Leprology. 76: 564-6. PMID 20827002 DOI: 10.4103/0378-6323.69042  0.8
2010 Li C, Biswas S, Li X, Dutta AK, Le W. Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin. Journal of Neuroscience Research. 88: 2513-23. PMID 20623619 DOI: 10.1002/jnr.22405  0.8
2010 Ghosh B, Antonio T, Gopishetty B, Reith M, Dutta A. Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol. Bioorganic & Medicinal Chemistry. 18: 5661-74. PMID 20605099 DOI: 10.1016/j.bmc.2010.06.025  0.32
2010 Ghosh B, Antonio T, Reith ME, Dutta AK. Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson's disease. Journal of Medicinal Chemistry. 53: 2114-25. PMID 20146482 DOI: 10.1021/jm901618d  0.8
2010 Zhen J, Antonio T, Dutta AK, Reith ME. Concentration of receptor and ligand revisited in a modified receptor binding protocol for high-affinity radioligands: [3H]Spiperone binding to D2 and D3 dopamine receptors. Journal of Neuroscience Methods. 188: 32-8. PMID 20122961 DOI: 10.1016/j.jneumeth.2010.01.031  0.8
2010 Schmitt KC, Mamidyala S, Biswas S, Dutta AK, Reith ME. Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter. Journal of Neurochemistry. 112: 1605-18. PMID 20067583 DOI: 10.1111/j.1471-4159.2010.06583.x  0.8
2010 Ghosh B, Antonio T, Zhen J, Kharkar P, Reith ME, Dutta AK. Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. Journal of Medicinal Chemistry. 53: 1023-37. PMID 20038106 DOI: 10.1021/jm901184n  0.8
2009 Kharkar PS, Batman AM, Zhen J, Beardsley PM, Reith ME, Dutta AK. Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters. Chemmedchem. 4: 1075-85. PMID 19449323 DOI: 10.1002/cmdc.200900085  0.8
2009 Brown DA, Mishra M, Zhang S, Biswas S, Parrington I, Antonio T, Reith ME, Dutta AK. Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. Bioorganic & Medicinal Chemistry. 17: 3923-33. PMID 19427222 DOI: 10.1016/j.bmc.2009.04.031  0.8
2008 Brown DA, Kharkar PS, Parrington I, Reith ME, Dutta AK. Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model. Journal of Medicinal Chemistry. 51: 7806-19. PMID 19053758 DOI: 10.1021/jm8008629  0.8
2008 Schmitt KC, Zhen J, Kharkar P, Mishra M, Chen N, Dutta AK, Reith ME. Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties. Journal of Neurochemistry. 107: 928-40. PMID 18786172 DOI: 10.1111/j.1471-4159.2008.05667.x  0.8
2008 Dutta AK, Ghosh B, Biswas S, Reith ME. D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action. European Journal of Pharmacology. 589: 73-9. PMID 18561912 DOI: 10.1016/j.ejphar.2008.05.008  0.8
2008 Biswas S, Hazeldine S, Ghosh B, Parrington I, Kuzhikandathil E, Reith ME, Dutta AK. Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity. Journal of Medicinal Chemistry. 51: 3005-19. PMID 18410082 DOI: 10.1021/jm701524h  0.8
2008 Mishra M, Kolhatkar R, Zhen J, Parrington I, Reith ME, Dutta AK. Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. Bioorganic & Medicinal Chemistry. 16: 2769-78. PMID 18249549 DOI: 10.1016/j.bmc.2008.01.009  0.8
2008 Biswas S, Zhang S, Fernandez F, Ghosh B, Zhen J, Kuzhikandathil E, Reith ME, Dutta AK. Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action. Journal of Medicinal Chemistry. 51: 101-17. PMID 18072730 DOI: 10.1021/jm070860r  0.8
2008 Kharkar PS, Reith ME, Dutta AK. Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors. Journal of Computer-Aided Molecular Design. 22: 1-17. PMID 18060532 DOI: 10.1007/s10822-007-9146-7  0.8
2006 Zhang S, Fernandez F, Hazeldine S, Deschamps J, Zhen J, Reith ME, Dutta AK. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. Journal of Medicinal Chemistry. 49: 4239-47. PMID 16821783 DOI: 10.1021/jm0601699  0.8
2006 Zhang S, Zhen J, Reith ME, Dutta AK. Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine. Bioorganic & Medicinal Chemistry. 14: 3953-66. PMID 16481172 DOI: 10.1016/j.bmc.2006.01.051  0.8
2005 Biswas S, Bhattacharyya J, Dutta AG. Oxidant induced injury of erythrocyte-role of green tea leaf and ascorbic acid. Molecular and Cellular Biochemistry. 276: 205-10. PMID 16132702 DOI: 10.1007/s11010-005-4062-4  0.52
2005 Zhang S, Zhen J, Reith ME, Dutta AK. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. Journal of Medicinal Chemistry. 48: 4962-71. PMID 16033275 DOI: 10.1021/jm049021k  0.8
2005 Reith ME, Wang LC, Dutta AK. Pharmacological profile of radioligand binding to the norepinephrine transporter: instances of poor indication of functional activity. Journal of Neuroscience Methods. 143: 87-94. PMID 15763140 DOI: 10.1016/j.jneumeth.2004.09.015  0.8
2004 Zhen J, Maiti S, Chen N, Dutta AK, Reith ME. Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter. European Journal of Pharmacology. 506: 17-26. PMID 15588620 DOI: 10.1016/j.ejphar.2004.10.028  0.8
2004 Zhang S, Zhen J, Reith ME, Dutta AK. Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters. Bioorganic & Medicinal Chemistry. 12: 6301-15. PMID 15519172 DOI: 10.1016/j.bmc.2004.07.069  0.8
2004 Kolhatkar R, Cook CD, Ghorai SK, Deschamps J, Beardsley PM, Reith ME, Dutta AK. Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters. Journal of Medicinal Chemistry. 47: 5101-13. PMID 15456254 DOI: 10.1021/jm049796t  0.8
2004 Dutta AK, Venkataraman SK, Fei XS, Kolhatkar R, Zhang S, Reith ME. Synthesis and biological characterization of novel hybrid 7-[[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors. Bioorganic & Medicinal Chemistry. 12: 4361-73. PMID 15265488 DOI: 10.1016/j.bmc.2004.06.019  0.8
2003 Dutta AK, Zhang S, Kolhatkar R, Reith ME. Dopamine transporter as target for drug development of cocaine dependence medications. European Journal of Pharmacology. 479: 93-106. PMID 14612141  0.8
2003 Kolhatkar RB, Ghorai SK, George C, Reith ME, Dutta AK. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. Journal of Medicinal Chemistry. 46: 2205-15. PMID 12747792 DOI: 10.1021/jm020561w  0.8
2003 Zhang S, Reith ME, Dutta AK. Design, synthesis, and activity of novel cis- and trans-3,6-disubstituted pyran biomimetics of 3,6-disubstituted piperidine as potential ligands for the dopamine transporter. Bioorganic & Medicinal Chemistry Letters. 13: 1591-5. PMID 12699762  0.8
2003 Ghorai SK, Cook C, Davis M, Venkataraman SK, George C, Beardsley PM, Reith ME, Dutta AK. High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo. Journal of Medicinal Chemistry. 46: 1220-8. PMID 12646032 DOI: 10.1021/jm020275k  0.8
2002 Dutta AK, Fei XS, Reith ME. A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: binding activity at D2 and D3 receptors. Bioorganic & Medicinal Chemistry Letters. 12: 619-22. PMID 11844685  0.8
2002 Dutta AK, Davis MC, Fei XS, Beardsley PM, Cook CD, Reith ME. Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules. Journal of Medicinal Chemistry. 45: 654-62. PMID 11806716  0.8
2001 Vaughan RA, Gaffaney JD, Lever JR, Reith ME, Dutta AK. Dual incorporation of photoaffinity ligands on dopamine transporters implicates proximity of labeled domains. Molecular Pharmacology. 59: 1157-64. PMID 11306699 DOI: 10.1124/mol.59.5.1157  0.32
2001 Dutta AK, Fei XS, Beardsley PM, Newman JL, Reith ME. Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters. Journal of Medicinal Chemistry. 44: 937-48. PMID 11300876 DOI: 10.1021/jm000311k  0.32
2001 Dutta AK, Fei XS, Vaughan RA, Gaffaney JD, Wang N, Lever JR, Reith ME. Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label. Life Sciences. 68: 1839-49. PMID 11292062 DOI: 10.1016/S0024-3205(01)00981-X  0.32
2001 Dutta AK, Reith ME, Madras BK. Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter. Synapse (New York, N.Y.). 39: 175-81. PMID 11180505 DOI: 10.1002/1098-2396(200102)39:2<175::AID-SYN9>3.0.CO;2-W  0.32
1998 Dutta AK, Coffey LL, Reith MEA. Potent and selective ligands for the dopamine transporter (DAT): Structure-activity relationship studies of novel 4-[2- (diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues Journal of Medicinal Chemistry. 41: 699-705. PMID 9513598 DOI: 10.1021/jm970595h  0.32
1997 Dutta AK, Ryan W, Thomas BF, Singer M, Compton DR, Martin BR, Razdan RK. Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs). Bioorganic & Medicinal Chemistry. 5: 1591-600. PMID 9313864 DOI: 10.1016/S0968-0896(97)00111-9  0.32
1997 Dutta AK, Coffey LL, Reith MEA. Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]-1- benzylpiperidine for the dopamine transporter: Effect of different aromatic substitutions on their affinity and selectivity Journal of Medicinal Chemistry. 40: 35-43. PMID 9016326 DOI: 10.1021/jm960638e  0.32
1994 Madras BK, Reith ME, Meltzer PC, Dutta AK. O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen. European Journal of Pharmacology. 267: 167-73. PMID 8050478 DOI: 10.1016/0922-4106(94)90168-6  0.32
1992 Sipahimalani AS, Werth JL, Michelson RH, Dutta AK, Efange SM, Thayer SA. Lipophilic amino alcohols with calcium channel blocking activity. Biochemical Pharmacology. 44: 2039-46. PMID 1449521 DOI: 10.1016/0006-2952(92)90107-T  0.32
1991 Efange SMN, Michelson RH, Dutta AK, Parsons SM. Acyclic analogues of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): Conformationally mobile inhibitors of vesicular acetylcholine transport Journal of Medicinal Chemistry. 34: 2638-2643. PMID 1875353  0.32
1990 Efange SMN, Michelson RH, Remmel RP, Boudreau RJ, Dutta AK, Freshler A. Flexible N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues: Synthesis and monoamine oxidase catalyzed bioactivation Journal of Medicinal Chemistry. 33: 3133-3138. PMID 2258899 DOI: 10.1021/jm00174a007  0.32
1980 Saha PC, Dutta AK, Ghosh BN. Sexual behaviour pattern of the male STD patients attending a treatment centre in Calcutta. Indian Journal of Public Health. 24: 16-22. PMID 6894135  0.84
1950 DUTTA AT, GHOSH BK, GUPTA JC. The seasonal variation of alkaloids in different parts of Holarrhena antidysenterica Wall. and the alkaloid content in the bark at different ages. Part 1. The Indian Journal of Medical Research. 38: 467-72. PMID 14840881  0.6
Show low-probability matches.