Daniel M. Watterson - Publications

Affiliations: 
Integrated Graduate Program in the Life Sciences Northwestern University, Evanston, IL 
Area:
Biochemistry, General Biophysics

129 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Bachstetter AD, Zhou Z, Rowe RK, Xing B, Goulding DS, Conley AN, Sompol P, Meier S, Abisambra JF, Lifshitz J, Watterson DM, Van Eldik LJ. MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses. Plos One. 11: e0149451. PMID 26871438 DOI: 10.1371/journal.pone.0149451  1
2015 Vilitkevich EL, Khapchaev AY, Kudryashov DS, Nikashin AV, Schavocky JP, Lukas TJ, Watterson DM, Shirinsky VP. Phosphorylation Regulates Interaction of 210-kDa Myosin Light Chain Kinase N-terminal Domain with Actin Cytoskeleton. Biochemistry. Biokhimii︠a︡. 80: 1288-97. PMID 26567572 DOI: 10.1134/S0006297915100090  0.64
2015 Webster SJ, Van Eldik LJ, Watterson DM, Bachstetter AD. Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6554-69. PMID 25904805 DOI: 10.1523/JNEUROSCI.0291-15.2015  0.8
2015 Bachstetter AD, Webster SJ, Goulding DS, Morton JE, Watterson DM, Van Eldik LJ. Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic. Journal of Neuroinflammation. 12: 69. PMID 25886256 DOI: 10.1186/s12974-015-0289-5  1
2015 Roy SM, Grum-Tokars VL, Schavocky JP, Saeed F, Staniszewski A, Teich AF, Arancio O, Bachstetter AD, Webster SJ, Van Eldik LJ, Minasov G, Anderson WF, Pelletier JC, Watterson DM. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. Acs Chemical Neuroscience. 6: 666-80. PMID 25676389 DOI: 10.1021/acschemneuro.5b00002  1
2014 Bachstetter AD, Webster SJ, Tu T, Goulding DS, Haiech J, Watterson DM, Van Eldik LJ. Generation and behavior characterization of CaMKIIβ knockout mice. Plos One. 9: e105191. PMID 25127391 DOI: 10.1371/journal.pone.0105191  1
2014 Bachstetter AD, Watterson DM, Van Eldik LJ. Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 9: 454-60. PMID 24789302 DOI: 10.1007/s11481-014-9543-3  1
2013 Watterson DM, Grum-Tokars VL, Roy SM, Schavocky JP, Bradaric BD, Bachstetter AD, Xing B, Dimayuga E, Saeed F, Zhang H, Staniszewski A, Pelletier JC, Minasov G, Anderson WF, Arancio O, et al. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. Plos One. 8: e66226. PMID 23840427 DOI: 10.1371/journal.pone.0066226  1
2012 Bachstetter AD, Norris CM, Sompol P, Wilcock DM, Goulding D, Neltner JH, St Clair D, Watterson DM, Van Eldik LJ. Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10201-10. PMID 22836255 DOI: 10.1523/JNEUROSCI.1496-12.2012  1
2012 Lukas TJ, Mirzoeva S, Watterson DM. Calmodulin-Regulated Protein Kinases Calmodulin and Signal Transduction. 65-168. DOI: 10.1016/B978-0-08-092636-0.50007-4  0.64
2012 Van Eldik LJ, Watterson DM. Calmodulin and Calcium Signal Transduction: An Introduction Calmodulin and Signal Transduction. 1-15. DOI: 10.1016/B978-0-08-092636-0.50005-0  1
2012 Van Eldik LJ, Watterson DM. Preface Calmodulin and Signal Transduction. xi-xiv. DOI: 10.1016/B978-0-08-092636-0.50004-9  1
2012 Van Eldik LJ, Watterson DM. Calmodulin and Signal Transduction Calmodulin and Signal Transduction. 1-482.  1
2011 Bachstetter AD, Xing B, de Almeida L, Dimayuga ER, Watterson DM, Van Eldik LJ. Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ). Journal of Neuroinflammation. 8: 79. PMID 21733175 DOI: 10.1186/1742-2094-8-79  1
2011 McNamara LK, Brunzelle JS, Schavocky JP, Watterson DM, Grum-Tokars V. Site-directed mutagenesis of the glycine-rich loop of death associated protein kinase (DAPK) identifies it as a key structure for catalytic activity. Biochimica Et Biophysica Acta. 1813: 1068-73. PMID 21126544 DOI: 10.1016/j.bbamcr.2010.11.011  0.56
2011 Chen T, Benmohamed R, Arvanites AC, Ralay Ranaivo H, Morimoto RI, Ferrante RJ, Watterson DM, Kirsch DR, Silverman RB. Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. Bioorganic & Medicinal Chemistry. 19: 613-22. PMID 21095130 DOI: 10.1016/j.bmc.2010.10.052  0.44
2010 Zimmermann M, Atmanene C, Xu Q, Fouillen L, Van Dorsselaer A, Bonnet D, Marsol C, Hibert M, Sanglier-Cianferani S, Pigault C, McNamara LK, Watterson DM, Haiech J, Kilhoffer MC. Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter. Plos One. 5: e14120. PMID 21152427 DOI: 10.1371/journal.pone.0014120  0.56
2009 Chico LK, Van Eldik LJ, Watterson DM. Targeting protein kinases in central nervous system disorders. Nature Reviews. Drug Discovery. 8: 892-909. PMID 19876042 DOI: 10.1038/nrd2999  1
2009 Silverman RB, Lawton GR, Ranaivo HR, Chico LK, Seo J, Watterson DM. Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration Bioorganic and Medicinal Chemistry. 17: 7593-7603. PMID 19796958 DOI: 10.1016/j.bmc.2009.08.065  0.44
2009 Chico LK, Behanna HA, Hu W, Zhong G, Roy SM, Watterson DM. Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 2204-11. PMID 19661215 DOI: 10.1124/dmd.109.028134  0.56
2009 Marchenko AV, Sidorova MV, Sekridova AV, Bushuev VN, Lakomkin VL, Orlova TsR, Stepanova OV, Kapel'ko VI, Watterson DM, Van Eldik LJ, Bespalova ZhD, ShirinskiÄ­ VP. [Penetrating peptide inhibitor of the myosin light chain kinase suppresses hyperpermeability of vascular endothelium]. RossiÄ­Skii FiziologicheskiÄ­ Zhurnal Imeni I.M. Sechenova / RossiÄ­Skaia Akademiia Nauk. 95: 507-15. PMID 19569527  1
2009 Somera-Molina KC, Nair S, Van Eldik LJ, Watterson DM, Wainwright MS. Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model. Brain Research. 1282: 162-72. PMID 19501063 DOI: 10.1016/j.brainres.2009.05.073  1
2009 McNamara LK, Watterson DM, Brunzelle JS. Structural insight into nucleotide recognition by human death-associated protein kinase. Acta Crystallographica. Section D, Biological Crystallography. 65: 241-8. PMID 19237746 DOI: 10.1107/S0907444908043679  0.56
2008 Borders AS, de Almeida L, Van Eldik LJ, Watterson DM. The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target. Bmc Neuroscience. 9: S12. PMID 19090985 DOI: 10.1186/1471-2202-9-S2-S12  1
2008 Karpus WJ, Reynolds N, Behanna HA, Van Eldik LJ, Watterson DM. Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug. Journal of Neuroimmunology. 203: 73-8. PMID 18678415 DOI: 10.1016/j.jneuroim.2008.06.039  1
2008 Lloyd E, Somera-Molina K, Van Eldik LJ, Watterson DM, Wainwright MS. Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. Journal of Neuroinflammation. 5: 28. PMID 18590543 DOI: 10.1186/1742-2094-5-28  1
2007 Guo X, Nakamura K, Kohyama K, Harada C, Behanna HA, Watterson DM, Matsumoto Y, Harada T. Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Neuroscience Research. 59: 457-66. PMID 17920148 DOI: 10.1016/j.neures.2007.08.014  0.44
2007 Munoz L, Ralay Ranaivo H, Roy SM, Hu W, Craft JM, McNamara LK, Chico LW, Van Eldik LJ, Watterson DM. A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. Journal of Neuroinflammation. 4: 21. PMID 17784957 DOI: 10.1186/1742-2094-4-21  1
2007 Somera-Molina KC, Robin B, Somera CA, Anderson C, Stine C, Koh S, Behanna HA, Van Eldik LJ, Watterson DM, Wainwright MS. Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation. Epilepsia. 48: 1785-800. PMID 17521344 DOI: 10.1111/j.1528-1167.2007.01135.x  1
2007 Ralay Ranaivo H, Carusio N, Wangensteen R, Ohlmann P, Loichot C, Tesse A, Chalupsky K, Lobysheva I, Haiech J, Watterson DM, Andriantsitohaina R. Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice. The American Journal of Pathology. 170: 439-46. PMID 17255312 DOI: 10.2353/ajpath.2007.060219  0.44
2007 Hu W, Ralay Ranaivo H, Roy SM, Behanna HA, Wing LK, Munoz L, Guo L, Van Eldik LJ, Watterson DM. Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits. Bioorganic & Medicinal Chemistry Letters. 17: 414-8. PMID 17079143 DOI: 10.1016/j.bmcl.2006.10.028  1
2006 Behanna HA, Watterson DM, Ralay Ranaivo H. Development of a novel bioavailable inhibitor of the calmodulin-regulated protein kinase MLCK: a lead compound that attenuates vascular leak. Biochimica Et Biophysica Acta. 1763: 1266-74. PMID 16996151 DOI: 10.1016/j.bbamcr.2006.08.007  0.44
2006 Wing LK, Behanna HA, Van Eldik LJ, Watterson DM, Ralay Ranaivo H. De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders. Current Alzheimer Research. 3: 205-14. PMID 16842097 DOI: 10.2174/156720506777632844  1
2006 Dudnakova TV, Stepanova OV, Dergilev KV, Chadin AV, Shekhonin BV, Watterson DM, Shirinsky VP. Myosin light chain kinase colocalizes with nonmuscle myosin IIB in myofibril precursors and sarcomeric Z-lines of cardiomyocytes. Cell Motility and the Cytoskeleton. 63: 375-83. PMID 16634081 DOI: 10.1002/cm.20127  0.36
2006 Ralay Ranaivo H, Craft JM, Hu W, Guo L, Wing LK, Van Eldik LJ, Watterson DM. Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 662-70. PMID 16407564 DOI: 10.1523/JNEUROSCI.4652-05.2006  1
2006 Craft JM, Watterson DM, Van Eldik LJ. Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration. Glia. 53: 484-90. PMID 16369931 DOI: 10.1002/glia.20306  1
2005 Craft JM, Watterson DM, Van Eldik LJ. Neuroinflammation: a potential therapeutic target. Expert Opinion On Therapeutic Targets. 9: 887-900. PMID 16185146 DOI: 10.1517/14728222.9.5.887  1
2005 Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. The Journal of Clinical Investigation. 115: 2702-15. PMID 16184195 DOI: 10.1172/JCI24970  1
2005 Ohlmann P, Tesse A, Loichot C, Ralay Ranaivo H, Roul G, Philippe C, Watterson DM, Haiech J, Andriantsitohaina R. Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function. American Journal of Physiology. Heart and Circulatory Physiology. 289: H2342-9. PMID 16055522 DOI: 10.1152/ajpheart.00511.2004  0.44
2005 Hu W, Ralay Ranaivo H, Craft JM, Van Eldik LJ, Watterson DM. Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model. Current Alzheimer Research. 2: 197-205. PMID 15974919 DOI: 10.2174/1567205053585828  1
2005 Craft JM, Watterson DM, Hirsch E, Van Eldik LJ. Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid. Journal of Neuroinflammation. 2: 15. PMID 15967035 DOI: 10.1186/1742-2094-2-15  1
2005 Craft JM, Watterson DM, Marks A, Van Eldik LJ. Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid. Glia. 51: 209-16. PMID 15810011 DOI: 10.1002/glia.20194  1
2004 Craft JM, Watterson DM, Frautschy SA, Van Eldik LJ. Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo. Neurobiology of Aging. 25: 1283-92. PMID 15465624 DOI: 10.1016/j.neurobiolaging.2004.01.006  0.6
2004 Craft JM, Van Eldik LJ, Zasadzki M, Hu W, Watterson DM. Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation. Journal of Molecular Neuroscience : Mn. 24: 115-22. PMID 15314259 DOI: 10.1385/JMN:24:1:115  1
2004 Kudryashov DS, Stepanova OV, Vilitkevich EL, Nikonenko TA, Nadezhdina ES, Shanina NA, Lukas TJ, Van Eldik LJ, Watterson DM, Shirinsky VP. Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain. Experimental Cell Research. 298: 407-17. PMID 15265689 DOI: 10.1016/j.yexcr.2004.04.025  1
2004 Schumacher AM, Schavocky JP, Velentza AV, Mirzoeva S, Watterson DM. A calmodulin-regulated protein kinase linked to neuron survival is a substrate for the calmodulin-regulated death-associated protein kinase. Biochemistry. 43: 8116-24. PMID 15209507 DOI: 10.1021/bi049589v  0.36
2003 Velentza AV, Wainwright MS, Zasadzki M, Mirzoeva S, Schumacher AM, Haiech J, Focia PJ, Egli M, Watterson DM. An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury. Bioorganic & Medicinal Chemistry Letters. 13: 3465-70. PMID 14505650 DOI: 10.1016/S0960-894X(03)00733-9  0.44
2003 Watterson DM, Velentza AV, Zasadzki M, Craft JM, Haiech J, Van Eldik LJ. Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against beta-amyloid induced injury: a foundation for future medicinal chemistry efforts focused on targeting Alzheimer's disease progression. Journal of Molecular Neuroscience : Mn. 20: 411-23. PMID 14501026 DOI: 10.1385/JMN:20:3:411  1
2003 Wainwright MS, Rossi J, Schavocky J, Crawford S, Steinhorn D, Velentza AV, Zasadzki M, Shirinsky V, Jia Y, Haiech J, Van Eldik LJ, Watterson DM. Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proceedings of the National Academy of Sciences of the United States of America. 100: 6233-8. PMID 12730364 DOI: 10.1073/pnas.1031595100  1
2002 Kudryashov DS, Vorotnikov AV, Dudnakova TV, Stepanova OV, Lukas TJ, Sellers JR, Watterson DM, Shirinsky VP. Smooth muscle myosin filament assembly under control of a kinase-related protein (KRP) and caldesmon. Journal of Muscle Research and Cell Motility. 23: 341-51. PMID 12630709 DOI: 10.1023/A:1022086228770  0.64
2002 Watterson DM, Haiech J, Van Eldik LJ. Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses. Journal of Molecular Neuroscience : Mn. 19: 89-93. PMID 12212800 DOI: 10.1007/s12031-002-0016-4  1
2002 Van Eldik LJ, Koppal T, Watterson DM. Barriers to Alzheimer disease drug discovery and development in academia. Alzheimer Disease and Associated Disorders. 16: S18-28. PMID 12070358  1
2002 Mirzoeva S, Sawkar A, Zasadzki M, Guo L, Velentza AV, Dunlap V, Bourguignon JJ, Ramstrom H, Haiech J, Van Eldik LJ, Watterson DM. Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. Journal of Medicinal Chemistry. 45: 563-6. PMID 11806708 DOI: 10.1021/jm015573g  1
2001 Krymsky MA, Kudryashov DS, Shirinsky VP, Lukas TJ, Watterson DM, Vorotnikov AV. Phosphorylation of kinase-related protein (telokin) in tonic and phasic smooth muscles. Journal of Muscle Research and Cell Motility. 22: 425-37. PMID 11964068 DOI: 10.1023/A:1014503604270  0.64
2001 Guo L, Sawkar A, Zasadzki M, Watterson DM, Van Eldik LJ. Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands. Neurobiology of Aging. 22: 975-81. PMID 11755006 DOI: 10.1016/S0197-4580(01)00295-0  1
2001 Lam AG, Koppal T, Akama KT, Guo L, Craft JM, Samy B, Schavocky JP, Watterson DM, Van Eldik LJ. Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB. Neurobiology of Aging. 22: 765-72. PMID 11705636 DOI: 10.1016/S0197-4580(01)00233-0  0.36
2001 Watterson DM, Mirzoeva S, Guo L, Whyte A, Bourguignon JJ, Hibert M, Haiech J, Van Eldik LJ. Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II. Neurochemistry International. 39: 459-68. PMID 11578781 DOI: 10.1016/S0197-0186(01)00053-5  1
2001 Velentza AV, Schumacher AM, Weiss C, Egli M, Watterson DM. A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates. The Journal of Biological Chemistry. 276: 38956-65. PMID 11483604 DOI: 10.1074/jbc.M104273200  0.36
1999 Kudryashov DS, Chibalina MV, Birukov KG, Lukas TJ, Sellers JR, Van Eldik LJ, Watterson DM, Shirinsky VP. Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton. Febs Letters. 463: 67-71. PMID 10601640 DOI: 10.1016/S0014-5793(99)01591-4  1
1999 Watterson DM, Schavocky JP, Guo L, Weiss C, Chlenski A, Shirinsky VP, Van Eldik LJ, Haiech J. Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker. Journal of Cellular Biochemistry. 75: 481-91. PMID 10536370 DOI: 10.1002/(SICI)1097-4644(19991201)75:3<481::AID-JCB12>3.0.CO;2-5  1
1999 Mirzoeva S, Koppal T, Petrova TV, Lukas TJ, Watterson DM, Van Eldik LJ. Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets. Brain Research. 844: 126-34. PMID 10536268 DOI: 10.1016/S0006-8993(99)01911-3  1
1999 Mirzoeva S, Weigand S, Lukas TJ, Shuvalova L, Anderson WF, Watterson DM. Analysis of the functional coupling between Calmodulin's calcium binding and peptide recognition properties Biochemistry. 38: 14117-8. PMID 10529260  0.64
1999 Maldonado RA, Mirzoeva S, Godsel LM, Lukas TJ, Goldenberg S, Watterson DM, Engman DM. Identification of calcium binding sites in the trypanosome flagellar calcium-acyl switch protein. Molecular and Biochemical Parasitology. 101: 61-70. PMID 10413043 DOI: 10.1016/S0166-6851(99)00055-9  0.64
1999 Mirzoeva S, Weigand S, Lukas TJ, Shuvalova L, Anderson WF, Watterson DM. Analysis of the functional coupling between calmodulin's calcium binding and peptide recognition properties. Biochemistry. 38: 3936-47. PMID 10194305 DOI: 10.1021/bi9821263  0.64
1999 Lukas TJ, Mirzoeva S, Slomczynska U, Watterson DM. Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. Journal of Medicinal Chemistry. 42: 910-9. PMID 10072688 DOI: 10.1021/jm980573a  0.64
1998 Birukov KG, Schavocky JP, Shirinsky VP, Chibalina MV, Van Eldik LJ, Watterson DM. Organization of the genetic locus for chicken myosin light chain kinase is complex: multiple proteins are encoded and exhibit differential expression and localization. Journal of Cellular Biochemistry. 70: 402-13. PMID 9706877 DOI: 10.1002/(SICI)1097-4644(19980901)70:3<402::AID-JCB13>3.0.CO;2-M  1
1998 Lukas TJ, Mirzoeva S, Watterson DM. Coupling of calmodulin's (CaM) calcium binding and enzyme recognition properties: Effects of a point mutation at the CaMipeptide interface Faseb Journal. 12.  0.64
1997 Silver DL, Vorotnikov AV, Watterson DM, Shirinsky VP, Sellers JR. Sites of interaction between kinase-related protein and smooth muscle myosin. The Journal of Biological Chemistry. 272: 25353-9. PMID 9312155 DOI: 10.1074/jbc.272.40.25353  0.36
1996 Bosc C, Cronk JD, Pirollet F, Watterson DM, Haiech J, Job D, Margolis RL. Cloning, expression, and properties of the microtubule-stabilizing protein STOP. Proceedings of the National Academy of Sciences of the United States of America. 93: 2125-30. PMID 8700896 DOI: 10.1073/pnas.93.5.2125  0.44
1995 Medvedeva MV, Bushueva TL, Shirinsky VP, Lukas TJ, Watterson DM, Gusev NB. Interaction of smooth muscle caldesmon with calmodulin mutants. Febs Letters. 360: 89-92. PMID 7875308 DOI: 10.1016/0014-5793(95)00058-H  0.64
1994 Lukas TJ, Collinge M, Haiech J, Watterson DM. Gain of function mutations for yeast calmodulin and calcium dependent regulation of protein kinase activity. Biochimica Et Biophysica Acta. 1223: 341-7. PMID 7918668 DOI: 10.1016/0167-4889(94)90093-0  0.64
1993 Farrar YJ, Lukas TJ, Craig TA, Watterson DM, Carlson GM. Features of calmodulin that are important in the activation of the catalytic subunit of phosphorylase kinase. The Journal of Biological Chemistry. 268: 4120-5. PMID 8440701  0.64
1993 Shirinsky VP, Vorotnikov AV, Birukov KG, Nanaev AK, Collinge M, Lukas TJ, Sellers JR, Watterson DM. A kinase-related protein stabilizes unphosphorylated smooth muscle myosin minifilaments in the presence of ATP Journal of Biological Chemistry. 268: 16578-16583. PMID 8344938  0.64
1992 Kilhoffer MC, Lukas TJ, Watterson DM, Haiech J. The heterodimer calmodulin: myosin light-chain kinase as a prototype vertebrate calcium signal transduction complex. Biochimica Et Biophysica Acta. 1160: 8-15. PMID 1420336 DOI: 10.1016/0167-4838(92)90033-A  0.64
1992 Collinge M, Matrisian PE, Zimmer WE, Shattuck RL, Lukas TJ, Van Eldik LJ, Watterson DM. Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene. Molecular and Cellular Biology. 12: 2359-71. PMID 1373815  1
1992 Timerman AP, Mayrleitner MM, Lukas TJ, Chadwick CC, Saito A, Watterson DM, Schindler H, Fleischer S. Inositol polyphosphate receptor and clathrin assembly protein AP-2 are related proteins that form potassium-selective ion channels in planar lipid bilayers. Proceedings of the National Academy of Sciences of the United States of America. 89: 8976-80. PMID 1329085  0.64
1991 Haiech J, Kilhoffer MC, Lukas TJ, Craig TA, Roberts DM, Watterson DM. Restoration of the calcium binding activity of mutant calmodulins toward normal by the presence of a calmodulin binding structure. The Journal of Biological Chemistry. 266: 3427-31. PMID 1995606  0.64
1991 Massom LR, Lukas TJ, Persechini A, Kretsinger RH, Watterson DM, Jarrett HW. Trifluoperazine binding to mutant calmodulins. Biochemistry. 30: 663-7. PMID 1988054  0.64
1991 Chabbert M, Lukas TJ, Watterson DM, Axelsen PH, Prendergast FG. Fluorescence analysis of calmodulin mutants containing tryptophan: conformational changes induced by calmodulin-binding peptides from myosin light chain kinase and protein kinase II. Biochemistry. 30: 7615-30. PMID 1854758  0.64
1990 Jiang K, Zheng J, Higgins SB, Watterson DM, Craig TA, Lukas TJ, Van Eldik LJ. A knowledge-based experimental design system for nucleic acid engineering. Computer Applications in the Biosciences : Cabios. 6: 205-12. PMID 2207744 DOI: 10.1093/bioinformatics/6.3.205  0.64
1990 Shoemaker MO, Lau W, Shattuck RL, Kwiatkowski AP, Matrisian PE, Guerra-Santos L, Wilson E, Lukas TJ, Van Eldik LJ, Watterson DM. Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity. The Journal of Cell Biology. 111: 1107-25. PMID 2202734  1
1990 Haiech J, Kilhoffer MC, Craig TA, Lukas TJ, Wilson E, Guerra-Santos L, Watterson DM. Mutant analysis approaches to understanding calcium signal transduction through calmodulin and calmodulin regulated enzymes. Advances in Experimental Medicine and Biology. 269: 43-56. PMID 2191562  0.64
1990 Van Eldik LJ, Zimmer WE, Barger SW, Watterson DM. Perturbation of the calmodulin system in transformed cells. Advances in Experimental Medicine and Biology. 269: 111-20. PMID 2162134  1
1989 Chabbert M, Kilhoffer MC, Watterson DM, Haiech J, Lami H. Time-resolved fluorescence study of VU-9 calmodulin, an engineered calmodulin possessing a single tryptophan residue. Biochemistry. 28: 6093-8. PMID 2775754  0.44
1989 Kilhoffer MC, Roberts DM, Adibi A, Watterson DM, Haiech J. Fluorescence characterization of VU-9 calmodulin, an engineered calmodulin with one tryptophan in calcium binding domain III. Biochemistry. 28: 6086-92. PMID 2775753  0.44
1989 Asselin J, Phaneuf S, Watterson DM, Haiech J. Metabolically 35S-labeled recombinant calmodulin as a ligand for the detection of calmodulin-binding proteins. Analytical Biochemistry. 178: 141-7. PMID 2658683 DOI: 10.1016/0003-2697(89)90370-9  0.44
1989 Weber PC, Lukas TJ, Craig TA, Wilson E, King MM, Kwiatkowski AP, Watterson DM. Computational and site-specific mutagenesis analyses of the asymmetric charge distribution on calmodulin Proteins: Structure, Function and Genetics. 6: 70-85. PMID 2558379  0.64
1989 Lukas TJ, Wallen-Friedman M, Kung C, Watterson DM. In vivo mutations of calmodulin: a mutant Paramecium with altered ion current regulation has an isoleucine-to-threonine change at residue 136 and an altered methylation state at lysine residue 115. Proceedings of the National Academy of Sciences of the United States of America. 86: 7331-5. PMID 2477839  0.64
1988 Lukas TJ, Haiech J, Lau W, Craig TA, Zimmer WE, Shattuck RL, Shoemaker MO, Watterson DM. Calmodulin and calmodulin-regulated protein kinases as transducers of intracellular calcium signals Cold Spring Harbor Symposia On Quantitative Biology. 53: 185-193. PMID 3254773  0.64
1988 Lukas TJ, Watterson DM. Purification of calmodulin and preparation of immobilized calmodulin Methods in Enzymology. 157: 328-339. PMID 3231092  0.64
1988 Kilhoffer MC, Roberts DM, Adibi AO, Watterson DM, Haiech J. Investigation of the mechanism of calcium binding to calmodulin. Use of an isofunctional mutant with a tryptophan introduced by site-directed mutagenesis Journal of Biological Chemistry. 263: 17023-17029. PMID 3182830  0.44
1988 Haiech J, Predeleanu R, Watterson DM, Ladant D, Bellalou J, Ullmann A, Barzus O. Affinity-based chromatography utilizing genetically engineered proteins. Interaction of Bordetella pertussis adenylate cyclase with calmodulin Journal of Biological Chemistry. 263: 4259-4262. PMID 2894377  0.44
1988 Watterson DM, Lukas TJ. Analysis of phosphodiesterase reaction mixtures by high-performance liquid chromatography Methods in Enzymology. 159: 471-477. PMID 2842612  0.64
1987 Schaefer WH, Lukas TJ, Blair IA, Schultz JE, Watterson DM. Amino acid sequence of a novel calmodulin from Paramecium tetraurelia that contains dimethyllysine in the first domain. The Journal of Biological Chemistry. 262: 1025-9. PMID 3100523  0.64
1987 Craig TA, Watterson DM, Prendergast FG, Haiech J, Roberts DM. Site-specific mutagenesis of the alpha-helices of calmodulin. Effects of altering a charge cluster in the helix that links the two halves of calmodulin Journal of Biological Chemistry. 262: 3278-3284. PMID 3029108  0.44
1986 Roberts DM, Rowe PM, Siegel FL, Lukas TJ, Watterson DM. Trimethyllysine and protein function. Effect of methylation and mutagenesis of lysine 115 of calmodulin on NAD kinase activation. The Journal of Biological Chemistry. 261: 1491-4. PMID 3003072  0.64
1986 Roberts DM, Lukas TJ, Watterson DM. Structure, function, and mechanism of action of calmodulin Critical Reviews in Plant Sciences. 4: 311-339. DOI: 10.1080/07352688609382230  0.64
1985 Jensen R, Marshak DR, Anderson C, Lukas TJ, Watterson DM. Characterization of Human Brain S100 Protein Fraction: Amino Acid Sequence of S100β Journal of Neurochemistry. 45: 700-705. PMID 4031854 DOI: 10.1111/j.1471-4159.1985.tb04048.x  0.64
1985 Marshak DR, Umekawa H, Watterson DM, Hidaka H. Structural characterization of the calcium binding protein S100 from adipose tissue Archives of Biochemistry and Biophysics. 240: 777-780. PMID 4026304 DOI: 10.1016/0003-9861(85)90086-4  0.44
1985 Lukas TJ, Marshak DR, Watterson DM. Drug-protein interactions: Isolation and characterization of covalent adducts of phenoxybenzamine and calmodulin Biochemistry. 24: 151-157. PMID 3994963  0.64
1985 Lukas TJ, Redelfs A, Burgess WH, Watterson DM. Amino acid sequence of the phosphorylation site of bovine cardiac myosin light chain Archives of Biochemistry and Biophysics. 238: 664-669. PMID 3838874 DOI: 10.1016/0003-9861(85)90212-7  0.64
1985 Marshak DR, Lukas TJ, Watterson DM. Drug-protein interactions: Binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins Biochemistry. 24: 144-150. PMID 2986673  0.64
1985 Lukas TJ, Watterson DM. Mechanisms of calmodulin-dependent protein kinases: Myosin light chain kinase Federation Proceedings. 44.  0.64
1985 Watterson DM, Wiggins ME, Lukas TJ. Primary structure of a calmodulin from the unicellular motile green alga Chlamydomonas reinhardtii Federation Proceedings. 44.  0.64
1985 Van Eldik LJ, Lukas TJ, Watterson DM. Engineering of site-directed antibodies against plant calmodulin Federation Proceedings. 44: No. 1839.  1
1984 Van Eldik LJ, Watterson DM, Burgess WH. Immunoreactive levels of myosin light-chain kinase in normal and virus-transformed chicken embryo fibroblasts. Molecular and Cellular Biology. 4: 2224-6. PMID 6390185  1
1984 Watterson DM, Burgess WH, Lukas TJ, Iverson D, Marshak DR, Schleicher M, Erickson BW, Fok KF, Van Eldik LJ. Towards a molecular and atomic anatomy of calmodulin and calmodulin-binding proteins. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 16: 205-26. PMID 6326525  1
1984 Schleicher M, Lukas TJ, Watterson DM. Isolation and characterization of calmodulin from the motile green alga Chlamydomonas reinhardtii Archives of Biochemistry and Biophysics. 229: 33-42. PMID 6322690 DOI: 10.1016/0003-9861(84)90127-9  0.64
1984 Zendegui JG, Zielinski RE, Watterson DM, Van Eldik LJ. Biosynthesis of calmodulin in normal and virus-transformed chicken embryo fibroblasts. Molecular and Cellular Biology. 4: 883-9. PMID 6203028  1
1984 Marshak DR, Clarke M, Roberts DM, Watterson DM. Structural and functional properties of calmodulin from the eukaryotic microorganism Dictyostelium discoideum Biochemistry. 23: 2891-2899. PMID 6087882  0.44
1984 Burgess WH, Watterson DM, Van Eldik LJ. Identification of calmodulin-binding proteins in chicken embryo fibroblasts. The Journal of Cell Biology. 99: 550-7. PMID 6086671  1
1984 Watterson DM, Lukas TJ, Roberts DM, Marshak DR. Novel functions and amino aid sequences of calmodulins from higher plants, the motile green alga chlamydomonas, and the slime mold dictyostelium Federation Proceedings. 43.  0.64
1983 Van Eldik LJ, Watterson DM, Fok KF, Erickson BW. Elucidation of a minimal immunoreactive site of vertebrate calmodulin. Archives of Biochemistry and Biophysics. 227: 522-33. PMID 6667029 DOI: 10.1016/0003-9861(83)90481-2  1
1983 Roberts DM, Zielinski RE, Schleicher M, Watterson DM. Analysis of suborganellar fractions from spinach and pea chloroplasts for calmodulin-binding proteins Journal of Cell Biology. 97: 1644-1647. PMID 6313700  0.4
1983 Van Eldik LJ, Fok KF, Erickson BW, Watterson DM. Engineering of site-directed antisera against vertebrate calmodulin by using synthetic peptide immunogens containing an immunoreactive site. Proceedings of the National Academy of Sciences of the United States of America. 80: 6775-9. PMID 6196776  1
1982 Van Eldik LJ, Zendegui JG, Marshak DR, Watterson DM. Calcium-binding proteins and the molecular basis of calcium action. International Review of Cytology. 77: 1-61. PMID 6757171  1
1982 Marshak DR, Watterson DM. Interaction of calcium modulated proteins and calmodulin fragments with immobilized phenothiazines Federation Proceedings. 41.  0.44
1981 Marshak DR, Watterson DM, Van Eldik LJ. Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine. Proceedings of the National Academy of Sciences of the United States of America. 78: 6793-7. PMID 6947252  1
1981 Van Eldik LJ, Watterson DM. Reproducible production of antiserum against vertebrate calmodulin and determination of the immunoreactive site. The Journal of Biological Chemistry. 256: 4205-10. PMID 6163780  1
1980 Watterson DM, Iverson DB, Van Eldik LJ. Spinach calmodulin: isolation, characterization, and comparison with vertebrate calmodulins. Biochemistry. 19: 5762-8. PMID 7459343  1
1980 Van Eldik LJ, Watterson DM. Reproducible production and characterization of anti-calmodulin antisera. Annals of the New York Academy of Sciences. 356: 437-8. PMID 6940510 DOI: 10.1111/j.1749-6632.1980.tb29663.x  1
1980 Marshak DR, Van Eldik LJ, Watterson DM. Isolation of a protein from brain using calcium-dependent affinity-based adsorption chromatography on phenothiazine-Sepharose conjugates. Annals of the New York Academy of Sciences. 356: 410-1. PMID 6940504 DOI: 10.1111/j.1749-6632.1980.tb29651.x  1
1980 Erickson BW, Watterson DM, Marshak DR. Sequence alignment of calmodulin domains by metric analysis. Annals of the New York Academy of Sciences. 356: 378-9. PMID 6940501 DOI: 10.1111/j.1749-6632.1980.tb29635.x  0.8
1980 Van Eldik LJ, Piperno G, Watterson DM. Similarities and dissimilarities between calmodulin and a Chlamydomonas flagellar protein. Proceedings of the National Academy of Sciences of the United States of America. 77: 4779-83. PMID 6254039  1
1980 Watterson DM, Iverson DB, Van Eldik LJ. Rapid separation and quantitation of 3',5'-cyclic nucleotides and 5'-nucleotides in phosphodiesterase reaction mixtures using high-performance liquid chromatography. Journal of Biochemical and Biophysical Methods. 2: 139-46. PMID 6252261 DOI: 10.1016/0165-022X(80)90021-4  1
1980 Van Eldik LJ, Piperno G, Watterson DM. Comparative biochemistry of calmodulins and calmodulin-like proteins. Annals of the New York Academy of Sciences. 356: 36-42. PMID 6112948 DOI: 10.1111/j.1749-6632.1980.tb29597.x  1
1980 Van Eldik LJ, Grossman AR, Iverson DB, Watterson DM. Isolation and characterization of calmodulin from spinach leaves and in vitro translation mixtures Proceedings of the National Academy of Sciences of the United States of America. 77: 1912-1916.  1
1979 Van Eldik LJ, Watterson DM. Characterization of a calcium-modulated protein from transformed chicken fibroblasts. The Journal of Biological Chemistry. 254: 10250-5. PMID 226538  1
1976 Watterson DM, Van Eldik LJ, Smith RE, Vanaman TC. Calcium-dependent regulatory protein of cyclic nucleotide metabolism in normal and transformed chicken embryo fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 73: 2711-5. PMID 183206  1
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